J:Prog. Neuropsychopharmacol. Biol. Psychiatry

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This page displays the top molecular interactions and top single events that were mentioned in the literature in this journal. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported in this journal. They are ordered first by their pain relevance and then by number of times they were reported in this journal. Text mining (TM) confidence, disease relevance and pain relevance are highlighted in green if they are judged to be high and red if not. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Reported in Journal Documents TM Confidence Disease Relevance Pain Relevance
1 INT120319 Ghrh Regulation of Ngf 1 2 0.25 1.89 2.11
2 INT120313 Gnrhr Negative_regulation of Mmp2 1 1 0.03 0.85 1.07
3 INT120315 Gnrhr Negative_regulation of Positive_regulation of Ngf 1 1 0.11 0.85 1.07
4 INT120318 Gnrhr Negative_regulation of Ngf 1 1 0.11 0.85 1.07
5 INT120317 Ghrh Regulation of Positive_regulation of Ngf 1 1 0.25 0.95 1.06
6 INT120311 Ghrh Regulation of Gene_expression of Ngf 1 1 0.25 0.95 1.06
7 INT120312 Ghrh Regulation of Tnf 1 1 0.26 0.95 1.05
8 INT120316 Ghrh Regulation of Il6 1 1 0.11 0.95 1.05
9 INT120314 Ghrh Regulation of Positive_regulation of Tnf 1 1 0.43 0.95 1.05
10 INT120310 Ghrh Regulation of Positive_regulation of Il6 1 1 0.18 0.95 1.05
11 INT77253 Binding of gr and Creb1 1 1 0.03 0.4 0.9
12 INT77254 Binding of gr and Sp1 1 1 0.04 0.4 0.9
13 INT152867 HTR1A Negative_regulation of Localization of S100b 1 1 0.46 0 0.75
14 INT57674 ecs Regulation of htr 1 1 0.01 0.15 0.35
15 INT104764 Binding of WAS and IL1RAPL1 1 1 0.00 0.17 0.15

Single Events

The table below shows the top 100 pain related interactions that have been reported in this journal. They are ordered first by their pain relevance and then by number of times they were reported in this journal. Text mining (TM) confidence, disease relevance and pain relevance are highlighted in green if they are judged to be high and red if not. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Reported in Journal Documents TM Confidence Disease Relevance Pain Relevance
1 INT158 Localization of Prl 3 2431 0.81 378.96 952.2
2 INT7114 Positive_regulation of Ltp 2 1192 0.62 290.76 755.77
3 INT728 Positive_regulation of Penk 2 1068 0.70 186.9 636.87
4 INT797 Regulation of Penk 2 812 0.62 111.13 542.24
5 INT5228 Positive_regulation of Fos 2 934 0.70 209.8 503.87
6 INT155 Positive_regulation of Prl 5 1233 0.70 317.93 457.82
7 INT1395 Negative_regulation of Penk 1 537 0.59 87.33 389.81
8 INT157 Positive_regulation of Localization of Prl 1 790 0.70 104.54 374.78
9 INT720 Positive_regulation of POMC 1 807 0.70 237.37 353.83
10 INT16260 Gene_expression of Bdnf 4 671 0.78 283.44 339.1
11 INT162 Regulation of Prl 3 794 0.62 165.01 322.24
12 INT5680 Gene_expression of Ngf 2 530 0.78 264.29 310.56
13 INT9131 Positive_regulation of Prkcg 1 431 0.70 130.8 302.41
14 INT1352 Localization of Acot1 8 728 0.80 73.01 296.01
15 INT886 Gene_expression of Pomc 1 676 0.78 129.87 295.98
16 INT9158 Gene_expression of Tnf 1 722 0.78 522.01 277.68
17 INT2365 Positive_regulation of Cck 1 354 0.70 87.8 277.41
18 INT16868 Gene_expression of Il6 2 807 0.78 499.48 256.57
19 INT3948 Regulation of Cck 2 291 0.62 58.07 255.88
20 INT738 Regulation of POMC 1 459 0.62 111.19 243.74
21 INT11377 Positive_regulation of Ngf 3 331 0.70 206.5 238
22 INT1562 Localization of Crh 4 499 0.81 126.74 236.68
23 INT5597 Gene_expression of Pdyn 4 433 0.78 62.97 235.47
24 INT767 Localization of Gnrhr 1 565 0.80 106.68 214.57
25 INT16259 Positive_regulation of Bdnf 2 336 0.70 183.48 209.82
26 INT2651 Positive_regulation of Pomc 4 403 0.70 95.72 206.24
27 INT11313 Positive_regulation of Il6 1 526 0.70 331.27 201.59
28 INT2211 Negative_regulation of Abat 1 267 0.59 66.51 200.98
29 INT156 Negative_regulation of Prl 3 542 0.59 131.97 192.24
30 INT6488 Gene_expression of Tnf 1 484 0.78 339.61 191.58
31 INT1652 Regulation of Pomc 1 387 0.62 61.01 186.51
32 INT49441 Negative_regulation of Cpox 5 494 0.59 303.22 177.46
33 INT7506 Negative_regulation of Ltp 1 267 0.46 91.01 176.8
34 INT1303 Negative_regulation of Npr1 1 278 0.55 35.1 156.78
35 INT2910 Regulation of Abat 1 169 0.62 36.95 153.53
36 INT13353 Positive_regulation of Tnf 1 332 0.70 248.75 148.1
37 INT425 Localization of PRL 1 455 0.81 189.64 144.8
38 INT5061 Negative_regulation of Mme 3 306 0.59 51.97 136.9
39 INT5595 Positive_regulation of Pdyn 3 223 0.70 48.37 130.14
40 INT65600 Positive_regulation of Casp3 5 376 0.70 198.44 128.03
41 INT695 Binding of POMC 1 304 0.48 56.66 126.85
42 INT5931 Regulation of Oprm1 1 149 0.62 18.15 125.93
43 INT16253 Positive_regulation of Gene_expression of Bdnf 2 196 0.70 92.67 113.01
44 INT7627 Negative_regulation of Positive_regulation of Ltp 1 162 0.50 41.2 106.27
45 INT114 Binding of Oprl1 1 139 0.48 23 103.35
46 INT1898 Regulation of Crh 1 220 0.62 61.33 102.64
47 INT940 Negative_regulation of Ptgs1 1 219 0.59 104.34 95.97
48 INT94953 Negative_regulation of Mapk14 1 156 0.59 104.77 91.51
49 INT5594 Regulation of Pdyn 1 137 0.62 27.04 86.63
50 INT16254 Positive_regulation of Gene_expression of Ngf 1 144 0.70 80.61 82.08
51 INT1309 Positive_regulation of Localization of Gnrhr 1 152 0.69 24.25 81.56
52 INT3657 Gene_expression of Ins1 1 514 0.78 321.69 75.76
53 INT1353 Negative_regulation of Localization of Acot1 5 153 0.53 15.05 75.17
54 INT5593 Positive_regulation of Gene_expression of Pdyn 2 114 0.70 29.1 74.46
55 INT58400 Negative_regulation of Tnf 1 182 0.59 129.97 71
56 INT6490 Negative_regulation of ADCY1 1 145 0.58 26.25 70.96
57 INT13276 Regulation of Ltp 1 107 0.53 30.78 69.13
58 INT6824 Regulation of Gene_expression of Pdyn 4 114 0.62 9.48 66.73
59 INT1603 Negative_regulation of Rtcd1 1 131 0.51 29.99 66.66
60 INT253 Regulation of PRL 2 184 0.62 47.27 65.79
61 INT1599 Positive_regulation of ADCY1 1 146 0.67 30.05 64.9
62 INT47690 Regulation of Bdnf 3 118 0.62 53.02 64.5
63 INT31116 Gene_expression of Casp3 1 192 0.78 78.21 57.43
64 INT1200 Negative_regulation of Ins1 1 274 0.58 155.17 56.14
65 INT19 Regulation of Gnrhr 1 131 0.62 36.4 55.66
66 INT5770 Binding of Rbm39 2 88 0.41 13.23 55.5
67 INT5506 Positive_regulation of Gene_expression of Pomc 1 132 0.70 26.78 54.3
68 INT2276 Regulation of Ins1 1 234 0.61 103.78 54.05
69 INT5509 Positive_regulation of Localization of Crh 3 91 0.70 30.65 53.92
70 INT1456 Regulation of Oprl1 1 61 0.62 19.5 52.87
71 INT6034 Binding of Gabrg1 1 115 0.47 17.48 51.92
72 INT62630 Positive_regulation of CNR1 1 86 0.70 40.34 51.51
73 INT921 Regulation of GH1 1 172 0.60 52.88 51.04
74 INT12471 Regulation of Insrr 1 52 0.35 17.8 48.31
75 INT789 Positive_regulation of YY1 1 69 0.67 14.07 47.06
76 INT8713 Regulation of Tac1 1 56 0.60 25.29 45.94
77 INT16194 Binding of CNR1 1 82 0.48 20.75 39.59
78 INT115 Negative_regulation of Maoa 1 65 0.59 16.27 38.66
79 INT3188 Regulation of Localization of Acot1 1 84 0.59 8.94 38.56
80 INT68975 Gene_expression of Mmp9 1 111 0.78 79.57 38.55
81 INT2416 Negative_regulation of MAOA 3 92 0.59 42.24 36.5
82 INT48959 Positive_regulation of Positive_regulation of Prkcg 1 52 0.70 16.47 36.49
83 INT1354 Negative_regulation of Acot1 3 87 0.43 15.01 36.44
84 INT70437 Negative_regulation of Mdk 1 115 0.57 41.03 35.72
85 INT1361 Negative_regulation of Gnrhr 1 118 0.58 57.77 35.54
86 INT65055 Negative_regulation of Nfkb1 1 83 0.58 44.85 34.94
87 INT7675 Gene_expression of ENG 2 146 0.77 45.35 34.6
88 INT11764 Positive_regulation of ENG 2 78 0.61 27.65 33.69
89 INT2884 Positive_regulation of CCK 1 66 0.69 25.25 30.6
90 INT5507 Regulation of Localization of Crh 1 57 0.61 8.43 30.26
91 INT7412 Positive_regulation of SST 1 71 0.70 24.44 29.48
92 INT18489 Binding of Man2a2 1 59 0.48 11.27 29.38
93 INT65597 Negative_regulation of Casp3 1 69 0.59 39.19 29.32
94 INT5514 Negative_regulation of Localization of Crh 1 64 0.58 8.12 29.29
95 INT66868 Positive_regulation of Ceacam3 1 40 0.69 26.61 28.9
96 INT65598 Negative_regulation of Positive_regulation of Casp3 3 45 0.59 18.36 28.59
97 INT16879 Binding of Crh 1 72 0.48 21.65 28.43
98 INT74726 Negative_regulation of Slc6a4 3 61 0.59 21.01 27.84
99 INT13995 Gene_expression of gr 1 96 0.74 48.21 26.54
100 INT605 Regulation of Acot1 1 61 0.62 10.7 26.34
101 INT67610 Positive_regulation of Pparg 1 53 0.70 31.91 25.2
102 INT5596 Negative_regulation of Gene_expression of Pdyn 1 41 0.59 5.34 24.36
103 INT682 Negative_regulation of AVP 1 97 0.59 50.67 23.91
104 INT47741 Negative_regulation of Flvcr2 1 43 0.51 5.72 23.37
105 INT3330 Gene_expression of AGT 1 149 0.76 98.65 22.73
106 INT11077 Positive_regulation of Htr3a 3 63 0.67 15.61 22.7
107 INT7715 Regulation of Drd2 1 35 0.62 10.79 22.3
108 INT74682 Positive_regulation of Mmp2 1 72 0.69 40.46 21.73
109 INT1156 Binding of CCK 2 27 0.48 8.71 20.58
110 INT78694 Positive_regulation of Gene_expression of Casp3 1 46 0.66 18.64 19.62
111 INT8075 Localization of Crh 1 64 0.81 25.41 19.45
112 INT7680 Regulation of Drd1a 1 27 0.45 4.52 18.86
113 INT6666 Negative_regulation of PENK 1 30 0.58 9.16 17.91
114 INT13790 Binding of HTR1A 3 52 0.47 18.83 17.59
115 INT9069 Regulation of Htr3a 1 29 0.60 6.18 16.55
116 INT49986 Transcription of Tnf 1 25 0.72 18.3 16.22
117 INT78697 Negative_regulation of Gene_expression of Casp3 1 33 0.57 11.22 16.16
118 INT6110 Negative_regulation of Gene_expression of Ins1 1 83 0.56 60.59 16.07
119 INT47742 Binding of Flvcr2 2 26 0.42 3.28 15.87
120 INT3466 Gene_expression of Ptger1 1 39 0.75 18.34 15.75
121 INT9751 Localization of Crhr1 1 26 0.78 10.47 15.69
122 INT14131 Regulation of HTR1A 1 34 0.60 9.61 14.74
123 INT7674 Regulation of ENG 2 42 0.30 11.41 14.44
124 INT24082 Negative_regulation of Sp1 1 13 0.40 1.19 13.11
125 INT27268 Localization of Gtf3a 1 71 0.21 56.93 12.51
126 INT83601 Binding of CNR2 1 30 0.47 7.79 12.37
127 INT100096 Regulation of Slc6a4 4 24 0.62 7.25 12.28
128 INT5515 Negative_regulation of Positive_regulation of Pomc 1 25 0.58 8.73 11.88
129 INT65277 Negative_regulation of Fst 4 20 0.43 4.61 11.83
130 INT50933 Transcription of Il6 1 38 0.72 24.31 11.58
131 INT68976 Positive_regulation of Gene_expression of Mmp9 1 34 0.42 28.21 11.28
132 INT50315 Positive_regulation of htr 2 20 0.61 1.96 11.22
133 INT17592 Positive_regulation of Regulation of Fos 1 21 0.67 3.54 10.07
134 INT1378 Negative_regulation of Regulation of Prl 1 27 0.43 9.16 9.9
135 INT2059 Positive_regulation of Negative_regulation of Prl 1 24 0.70 5.7 9.37
136 INT8249 Positive_regulation of Cubn 1 15 0.66 4.05 9.35
137 INT52924 Negative_regulation of GSR 1 49 0.58 28.08 9.28
138 INT3467 Positive_regulation of Ptger1 1 28 0.54 10.59 8.93
139 INT30247 Regulation of Adrb1 1 18 0.44 4.45 8.93
140 INT52442 Binding of Ptgs1 1 16 0.35 9.05 8.78
141 INT3622 Regulation of CTSB 1 34 0.58 16.08 8.76
142 INT34268 Binding of WAS 1 14 0.47 4.41 8.67
143 INT7673 Negative_regulation of ENG 2 31 0.42 7.9 8.61
144 INT77249 Positive_regulation of Gene_expression of gr 1 24 0.67 16.09 8.17
145 INT1591 Negative_regulation of Binding of POMC 1 18 0.59 1.74 7.91
146 INT6335 Binding of TSPO 2 39 0.44 10.88 7.66
147 INT26707 Binding of PPAP2A 1 21 0.35 6.01 7.43
148 INT5578 Regulation of da 2 10 0.39 2.92 7.26
149 INT60931 Negative_regulation of Fst 2 15 0.57 5.44 7.21
150 INT32903 Negative_regulation of PPAP2A 4 14 0.48 5.02 7.2
151 INT96969 Positive_regulation of Positive_regulation of CNR1 1 9 0.48 1.27 7.19
152 INT18578 Binding of Eef1a1 1 20 0.48 2.53 6.95
153 INT117299 Localization of S100b 6 19 0.78 1.58 6.8
154 INT21138 Binding of ADRA2A 1 16 0.48 5.57 6.8
155 INT58700 Binding of Slc16a11 2 11 0.42 1.17 6.38
156 INT23465 Gene_expression of S100b 1 31 0.76 15.09 6.2
157 INT2137 Localization of Cea 2 27 0.70 19.22 6.14
158 INT35536 Negative_regulation of CAT 1 26 0.57 14.39 5.38
159 INT77252 Gene_expression of Nr3c1 1 17 0.67 9.71 5.38
160 INT21067 Regulation of Regulation of PRL 1 11 0.60 2 5.31
161 INT53536 Gene_expression of Bw86 1 8 0.30 0.89 5.21
162 INT65276 Gene_expression of Fst 1 12 0.65 4.99 5.05
163 INT92054 Positive_regulation of Transcription of Tnf 1 8 0.50 4.93 5.05
164 INT26670 Regulation of Positive_regulation of Pdyn 1 11 0.45 0.94 4.96
165 INT104760 Localization of MT1A 5 13 0.44 1.5 4.85
166 INT3128 Negative_regulation of PON1 3 30 0.59 26.19 4.57
167 INT83407 Negative_regulation of Gucy1b2 2 11 0.58 0.9 4.2
168 INT144702 Gene_expression of Tst 2 19 0.68 12.87 4.04
169 INT48456 Localization of WAS 1 6 0.56 1.63 3.95
170 INT34476 Regulation of Regulation of Cck 1 3 0.34 0.71 3.78
171 INT3854 Binding of SCD 1 16 0.41 11.14 3.7
172 INT77251 Positive_regulation of Atf2 2 8 0.70 2.45 3.62
173 INT5603 Regulation of Ptgdr 1 5 0.45 0.06 3.55
174 INT135373 Regulation of Gsk3b 2 35 0.62 18.11 3.53
175 INT37532 Positive_regulation of Bst1 1 5 0.40 2.23 3.37
176 INT94947 Positive_regulation of Transcription of Il6 1 9 0.67 6.91 3.04
177 INT32222 Negative_regulation of Gene_expression of ENG 1 9 0.37 2.23 2.89
178 INT77250 Positive_regulation of Gene_expression of Nr3c1 1 4 0.44 3.32 2.64
179 INT152865 Positive_regulation of Localization of S100b 2 3 0.68 0 2.53
180 INT3410 Positive_regulation of Artles 1 9 0.04 2.57 2.5
181 INT4715 Positive_regulation of Xdh 1 20 0.69 6.57 2.28
182 INT105760 Negative_regulation of Casr 1 5 0.58 0.93 2.17
183 INT41495 Regulation of Sp1 1 7 0.42 2.96 2.05
184 INT138316 Regulation of Fst 1 5 0.44 1.15 1.99
185 INT105704 Positive_regulation of Regulation of Oprl1 1 2 0.46 1.23 1.95
186 INT38014 Regulation of Casr 1 7 0.31 1.14 1.87
187 INT116813 Gene_expression of Ppbp 1 5 0.66 2.28 1.84
188 INT104759 Positive_regulation of MT1A 2 3 0.26 0.28 1.84
189 INT104761 Positive_regulation of Localization of MT1A 2 1 0.38 0.23 1.84
190 INT57673 Regulation of Positive_regulation of htr 1 2 0.24 0.27 1.76
191 INT94524 Gene_expression of MT1A 1 6 0.39 1.66 1.75
192 INT57672 Regulation of htr 1 2 0.15 0.16 1.68
193 INT152864 Regulation of Localization of S100b 1 2 0.52 0 1.66
194 INT43327 Positive_regulation of ADRA2A 1 3 0.46 1.54 1.53
195 INT1215 Negative_regulation of PGE 2 19 0.47 4.6 1.52
196 INT32352 Negative_regulation of Nil 1 6 0.41 1.68 1.43
197 INT6200 Negative_regulation of Gene_expression of Ptger1 1 3 0.02 0.64 1.17
198 INT12555 Binding of ADRB1 1 7 0.39 3.78 0.97
199 INT115069 Positive_regulation of Localization of Cea 1 5 0.34 3.31 0.95
200 INT58050 Regulation of Binding of Crh 1 2 0.42 0.84 0.86
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