J:Proteome Sci

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This page displays the top molecular interactions and top single events that were mentioned in the literature in this journal. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported in this journal. They are ordered first by their pain relevance and then by number of times they were reported in this journal. Text mining (TM) confidence, disease relevance and pain relevance are highlighted in green if they are judged to be high and red if not. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Reported in Journal Documents TM Confidence Disease Relevance Pain Relevance
1 INT201241 Positive_regulation of GDI2 Positive_regulation of Regulation of AGFG1 1 1 0.01 0 0.82
2 INT181294 HBM Positive_regulation of NGB 1 1 0.02 0.74 0.3
3 INT181295 MB Positive_regulation of NGB 1 1 0.10 0.73 0.3
4 INT287763 Binding of Gria2 and Ap3m1 1 1 0.02 0.33 0.21
5 INT353808 HLA-DMA Regulation of HLA-B 1 2 0.00 1.72 0.19
6 INT192219 CASP3 Regulation of ESR1 1 1 0.03 1.19 0.19
7 INT287764 Binding of Gria2 and Nsf 1 1 0.34 0.33 0.18
8 INT214958 Ss18 Regulation of Rims1 1 1 0.15 0 0.12
9 INT214953 Syt1 Regulation of Rims1 1 1 0.25 0 0.12
10 INT214952 Vamp2 Regulation of Rims1 1 1 0.17 0 0.12
11 INT214956 Vamp1 Regulation of Rims1 1 1 0.17 0 0.12
12 INT214955 Binding of Syt1 and Vamp2 1 1 0.22 0 0.1
13 INT214957 Vamp2 Regulation of Neu3 1 1 0.00 0 0.1
14 INT214951 Binding of Syt1 and Vamp1 1 1 0.22 0 0.1
15 INT214954 Vamp1 Regulation of Neu3 1 1 0.00 0 0.1
16 INT348933 Binding of ALB and ERLEC1 1 1 0.02 0.47 0
17 INT235181 IRF6 Positive_regulation of RASGRP1 1 2 0.00 0.2 0
18 INT235182 IRF6 Positive_regulation of VIM 1 1 0.05 0.08 0
19 INT348936 Binding of CD59 and ERLEC1 1 1 0.03 0.48 0
20 INT348934 Binding of ITIH4 and ERLEC1 1 1 0.03 0.47 0
21 INT304608 Binding of GYPA and Epb4.1 1 1 0.00 0.4 0
22 INT321594 Bmp2 Regulation of Gene_expression of Lxn 1 4 0.42 1.71 0
23 INT348935 Binding of KNG1 and ERLEC1 1 1 0.03 0.48 0
24 INT178324 Pts Regulation of Akt1 1 1 0.00 0.23 0

Single Events

The table below shows the top 100 pain related interactions that have been reported in this journal. They are ordered first by their pain relevance and then by number of times they were reported in this journal. Text mining (TM) confidence, disease relevance and pain relevance are highlighted in green if they are judged to be high and red if not. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Reported in Journal Documents TM Confidence Disease Relevance Pain Relevance
1 INT34869 Negative_regulation of PTGS2 1 778 0.59 366.76 319.85
2 INT11624 Gene_expression of OPRM1 2 445 0.78 72.36 294.36
3 INT120811 Gene_expression of Gopc 1 1174 0.59 428.49 150.55
4 INT812 Localization of INS 1 1026 0.81 515.6 145.31
5 INT17612 Gene_expression of CRP 1 676 0.78 580.61 119.03
6 INT11587 Gene_expression of CSF2 1 645 0.78 544.38 93.89
7 INT5056 Gene_expression of IFNG 1 216 0.78 137.52 74.57
8 INT8357 Gene_expression of KNG1 9 153 0.75 77.26 68.66
9 INT7134 Localization of KNG1 1 127 0.79 65.73 67.97
10 INT822 Gene_expression of ESR1 7 529 0.78 302.16 63.64
11 INT1579 Gene_expression of PRL 1 279 0.78 119.2 55.41
12 INT78899 Gene_expression of CCL5 1 155 0.77 84.02 55.09
13 INT1322 Positive_regulation of Localization of INS 1 293 0.70 120.86 45.98
14 INT19078 Binding of Ngf 1 78 0.48 31.03 44.33
15 INT170054 Negative_regulation of Gopc 1 280 0.38 117.89 42.4
16 INT3758 Gene_expression of ALB 7 326 0.78 184.65 38.75
17 INT68975 Gene_expression of Mmp9 3 111 0.78 79.57 38.55
18 INT9082 Positive_regulation of ESR1 1 238 0.69 148.51 36.69
19 INT3971 Positive_regulation of Alb 1 175 0.70 98.46 36.45
20 INT81530 Gene_expression of Nfkb1 1 93 0.78 48.58 32.58
21 INT29503 Gene_expression of Mmp2 1 95 0.77 56.92 31.68
22 INT608 Negative_regulation of KNG1 2 98 0.43 72.36 31.23
23 INT68973 Positive_regulation of Mmp9 5 89 0.52 58.56 30.04
24 INT28361 Gene_expression of TP53 1 443 0.78 384.86 28.8
25 INT15610 Localization of GOPC 1 223 0.65 68.26 28.7
26 INT5653 Positive_regulation of ELANE 6 136 0.70 72.78 27.94
27 INT3076 Regulation of KNG1 2 52 0.60 20.39 27.89
28 INT22045 Gene_expression of IRF6 8 158 0.75 58.07 27.81
29 INT64499 Positive_regulation of IRF6 1 123 0.49 52.73 27.51
30 INT2569 Gene_expression of Ache 1 120 0.78 26.29 26.89
31 INT20462 Binding of ESR1 2 210 0.44 102.7 26.34
32 INT53482 Gene_expression of ITIH4 9 75 0.77 58.87 26.05
33 INT1728 Negative_regulation of Cndp2 1 36 0.57 3.76 25.39
34 INT86295 Gene_expression of Mmp2 1 114 0.76 73.68 24.25
35 INT22708 Gene_expression of MUC1 6 297 0.78 232.71 24.19
36 INT5905 Negative_regulation of ELANE 14 113 0.59 47.43 22.09
37 INT8580 Gene_expression of ELANE 1 132 0.75 62.98 21.79
38 INT74682 Positive_regulation of Mmp2 2 72 0.69 40.46 21.73
39 INT97798 Localization of IRF6 7 86 0.73 33.27 20.94
40 INT5096 Positive_regulation of Gtf3a 1 79 0.60 42.26 20.62
41 INT14737 Gene_expression of FN1 2 117 0.78 78.74 18.99
42 INT28215 Gene_expression of CDKN1A 1 196 0.76 113.9 18.3
43 INT2120 Gene_expression of CD79A 1 159 0.78 111.69 17.16
44 INT13510 Gene_expression of ERBB2 4 530 0.78 405.68 16.79
45 INT93361 Gene_expression of Trp53 1 208 0.78 175.35 16.65
46 INT10214 Gene_expression of VIM 1 153 0.78 115.88 16.29
47 INT20420 Gene_expression of MYC 1 99 0.75 49.32 14.36
48 INT4736 Gene_expression of Chat 1 67 0.77 17.15 14.24
49 INT22046 Negative_regulation of IRF6 3 52 0.43 25.69 14.13
50 INT18773 Localization of ALB 1 117 0.80 69.18 13.8
51 INT52714 Regulation of PRKCA 1 28 0.61 7.73 13.66
52 INT4931 Localization of IFNG 1 53 0.78 33.25 13.65
53 INT78472 Gene_expression of CDKN2A 1 223 0.78 173.76 13.61
54 INT99586 Binding of IRF6 1 60 0.36 27.87 13.2
55 INT27242 Gene_expression of PGR 4 153 0.75 98.77 12.79
56 INT2129 Positive_regulation of F2 2 83 0.70 58.95 12.63
57 INT31990 Positive_regulation of SOD1 5 124 0.69 67.79 12.52
58 INT14510 Gene_expression of SOD1 16 208 0.76 88.56 12.4
59 INT79545 Positive_regulation of Gene_expression of ESR1 1 82 0.64 39.42 12.18
60 INT68976 Positive_regulation of Gene_expression of Mmp9 2 34 0.42 28.21 11.28
61 INT4498 Gene_expression of F2 1 83 0.65 57.4 10.8
62 INT22132 Positive_regulation of CAT 1 41 0.67 18.64 10.67
63 INT100379 Positive_regulation of HIF1A 1 69 0.69 57.31 10.4
64 INT94784 Binding of ROS1 1 113 0.40 71.57 10.26
65 INT78895 Regulation of CCL5 1 30 0.46 20.45 10.18
66 INT61171 Gene_expression of S100A8 1 92 0.76 57.74 9.98
67 INT178306 Negative_regulation of Gene_expression of Gopc 1 71 0.37 26.43 9.74
68 INT10139 Positive_regulation of F13A1 1 64 0.56 44.75 9.69
69 INT11679 Negative_regulation of F13A1 1 55 0.54 33.69 9.43
70 INT125247 Negative_regulation of Mmp9 13 42 0.43 23.68 9.37
71 INT181307 Gene_expression of NGB 23 1 0.76 11.15 9.18
72 INT27551 Gene_expression of SERPINH1 2 45 0.62 42.87 9.04
73 INT69264 Gene_expression of KIT 2 207 0.78 179.41 8.95
74 INT80420 Gene_expression of IFI27 1 145 0.78 63.61 8.83
75 INT224366 Gene_expression of Ager 1 111 0.77 125.37 8.49
76 INT111607 Gene_expression of CDH1 2 103 0.75 90.45 7.77
77 INT17501 Negative_regulation of F2 3 70 0.58 32.23 7.51
78 INT70252 Gene_expression of Ugt1a6 1 20 0.77 3.89 7.45
79 INT97055 Positive_regulation of Gene_expression of Trp53 1 51 0.70 45.7 7.25
80 INT58365 Gene_expression of LTF 1 51 0.78 44.14 7.25
81 INT67822 Binding of SERPINH1 1 17 0.36 19.05 7.24
82 INT69439 Regulation of ROS1 1 46 0.45 31.22 6.94
83 INT14903 Negative_regulation of SOD1 6 81 0.57 42.02 6.91
84 INT3757 Positive_regulation of Gene_expression of ALB 1 45 0.69 23.73 6.85
85 INT33781 Binding of Pebp1 2 11 0.44 1.76 6.61
86 INT39516 Gene_expression of Alb 1 81 0.75 30.08 6.59
87 INT16068 Gene_expression of SERPINB1 1 27 0.60 20.51 6.56
88 INT48239 Binding of Gtf3a 1 52 0.33 23.14 6.45
89 INT1280 Negative_regulation of Pebp1 1 7 0.28 2.12 6.45
90 INT76096 Positive_regulation of Gene_expression of IRF6 2 37 0.49 14.24 6.39
91 INT192225 Gene_expression of HDAC9 3 35 0.58 32.82 6.36
92 INT11814 Positive_regulation of Alb 2 43 0.63 31.71 6.28
93 INT150417 Negative_regulation of Gene_expression of IRF6 1 20 0.41 11.48 6.28
94 INT57720 Localization of IGHG3 1 33 0.74 20.24 6.25
95 INT24042 Gene_expression of MUC5AC 1 98 0.77 74.99 6.18
96 INT2890 Positive_regulation of MB 1 39 0.70 29.58 6.01
97 INT75501 Gene_expression of CCND1 1 90 0.76 60.86 5.93
98 INT104330 Negative_regulation of CDKN1A 1 57 0.58 39.93 5.88
99 INT16688 Positive_regulation of Cndp2 1 11 0.49 1.12 5.86
100 INT87468 Negative_regulation of Mmp2 1 24 0.57 10.79 5.55
101 INT21609 Positive_regulation of RASGRP1 1 58 0.50 40.78 5.47
102 INT118124 Binding of USE1 1 24 0.16 16.64 5.44
103 INT77281 Negative_regulation of HIVEP1 1 132 0.49 102.78 5.36
104 INT3165 Gene_expression of LYZ 1 25 0.65 16.72 5.16
105 INT28084 Positive_regulation of VIM 1 49 0.67 35.12 5.15
106 INT73262 Negative_regulation of BCL2 1 67 0.57 61.01 5.07
107 INT100059 Gene_expression of MUC4 1 30 0.75 31.58 4.95
108 INT10138 Negative_regulation of Gene_expression of KNG1 2 13 0.57 9.57 4.9
109 INT16214 Localization of F13A1 1 36 0.74 21.8 4.87
110 INT81485 Negative_regulation of IL1RN 1 19 0.57 8.3 4.69
111 INT133630 Negative_regulation of Gene_expression of ESR1 1 42 0.52 23.89 4.57
112 INT44066 Gene_expression of Ltf 1 20 0.77 15.09 4.57
113 INT181886 Gene_expression of Apoa1 2 40 0.64 40.53 4.56
114 INT79902 Gene_expression of AQP1 2 33 0.78 24.72 4.55
115 INT138779 Positive_regulation of Localization of IRF6 1 25 0.45 11.51 4.51
116 INT9842 Binding of F2 1 36 0.47 22.79 4.42
117 INT47766 Transcription of Fos 1 25 0.69 8.78 4.42
118 INT125896 Negative_regulation of Gene_expression of Mmp9 1 15 0.43 13.73 4.18
119 INT22838 Gene_expression of Fgg 1 26 0.25 19.9 3.88
120 INT84809 Positive_regulation of Gene_expression of MUC1 1 39 0.70 36.42 3.75
121 INT73602 Positive_regulation of Ager 1 35 0.69 30.66 3.74
122 INT111185 Gene_expression of MOP-1 1 4 0.62 0.23 3.66
123 INT49006 Gene_expression of Neu3 2 13 0.08 1.22 3.63
124 INT24231 Localization of SERPINB1 1 13 0.61 3.1 3.61
125 INT79477 Binding of HLA-DMA 1 19 0.26 13.78 3.47
126 INT157342 Gene_expression of S100A9 2 19 0.60 21.27 3.37
127 INT21572 Gene_expression of Pebp1 2 9 0.71 2.52 3.3
128 INT78297 Gene_expression of CD59 7 31 0.72 24.11 3.18
129 INT62112 Binding of S100A8 1 37 0.36 17.18 3.16
130 INT9884 Localization of CD79A 2 41 0.78 21.75 3.06
131 INT8103 Binding of TP53 1 46 0.44 40.2 2.96
132 INT181008 Negative_regulation of Localization of IRF6 1 13 0.14 2.32 2.96
133 INT1653 Positive_regulation of DSP 1 8 0.49 3.3 2.93
134 INT47770 Positive_regulation of Transcription of Fos 1 9 0.49 1.87 2.71
135 INT90875 Negative_regulation of CCND1 1 31 0.42 26.22 2.66
136 INT178291 Gene_expression of Hps1 8 26 0.67 8.2 2.52
137 INT120483 Localization of ITIH4 1 11 0.69 12.05 2.51
138 INT92141 Negative_regulation of CDKN2A 1 53 0.57 44.23 2.48
139 INT181880 Positive_regulation of Apoa1 2 19 0.66 21.19 2.43
140 INT60765 Gene_expression of LAMB2 1 28 0.49 13.93 2.38
141 INT20263 Gene_expression of Chka 1 5 0.06 0.8 2.37
142 INT40565 Gene_expression of SLPI 1 15 0.75 7.25 2.21
143 INT96856 Localization of NOSTRIN 2 8 0.49 6.39 2.19
144 INT68496 Binding of PGR 1 26 0.48 16.36 2.09
145 INT96764 Positive_regulation of Gene_expression of SOD1 8 36 0.61 16.55 1.99
146 INT112089 Gene_expression of Cav1 6 73 0.75 23.8 1.97
147 INT50895 Regulation of GYPA 1 10 0.60 4.05 1.95
148 INT20421 Positive_regulation of MYC 1 19 0.67 10.43 1.9
149 INT191154 Binding of HDAC9 1 20 0.36 14.12 1.83
150 INT61627 Transcription of IFNG 1 6 0.69 4.28 1.83
151 INT111603 Positive_regulation of Gene_expression of CDH1 1 14 0.49 11.17 1.72
152 INT16782 Binding of ERLEC1 4 15 0.10 8.23 1.7
153 INT21788 Positive_regulation of ERBB2 1 49 0.66 28.88 1.68
154 INT201256 Positive_regulation of RBBP7 2 1 0.35 0 1.68
155 INT26451 Gene_expression of KLK1 1 14 0.75 5.79 1.66
156 INT181309 Positive_regulation of Gene_expression of NGB 2 1 0.46 1.84 1.65
157 INT201249 Positive_regulation of RUVBL1 2 1 0.16 0 1.63
158 INT29777 Negative_regulation of CD59 2 16 0.42 14.88 1.56
159 INT77314 Gene_expression of Lxn 9 3 0.76 5.67 1.55
160 INT39376 Positive_regulation of HK1 1 6 0.53 2.44 1.49
161 INT93956 Binding of HBM 1 20 0.35 8.86 1.48
162 INT181881 Positive_regulation of Gene_expression of Apoa1 2 13 0.48 14.31 1.45
163 INT31719 Negative_regulation of Ctsa 1 6 0.47 6.1 1.43
164 INT160950 Gene_expression of Cntn1 2 5 0.53 1.7 1.38
165 INT119062 Negative_regulation of BRCA1 1 12 0.49 13.7 1.36
166 INT200991 Negative_regulation of GNB2L1 2 2 0.28 0.18 1.33
167 INT125897 Binding of Mmp9 1 3 0.36 2.36 1.32
168 INT89765 Positive_regulation of NR4A1 1 12 0.69 8.13 1.23
169 INT35587 Protein_catabolism of Atrn 1 4 0.03 2.34 1.21
170 INT118196 Gene_expression of ROM1 1 18 0.66 4.81 1.19
171 INT57689 Localization of CD59 1 7 0.78 4.51 1.17
172 INT159543 Localization of SOD1 2 29 0.75 8.62 1.06
173 INT129398 Negative_regulation of Gene_expression of SOD1 1 22 0.43 7.11 1.02
174 INT187188 Binding of PPIA 1 3 0.47 1.1 1.01
175 INT166889 Positive_regulation of Gene_expression of AQP1 1 10 0.70 6.43 0.99
176 INT185929 Regulation of Gene_expression of IRF6 1 9 0.20 1.66 0.99
177 INT191530 Regulation of Gene_expression of KNG1 1 4 0.26 0.71 0.96
178 INT108243 Positive_regulation of Prdx2 1 3 0.34 0.85 0.95
179 INT10373 Gene_expression of ADI1 1 8 0.25 5.97 0.92
180 INT201261 Regulation of AGFG1 1 4 0.09 2.72 0.9
181 INT224365 Positive_regulation of Gene_expression of Ager 1 13 0.69 11.6 0.88
182 INT46430 Binding of ME1 1 4 0.28 1.22 0.88
183 INT201251 Negative_regulation of NAPA 1 2 0.30 0 0.88
184 INT201254 Positive_regulation of Positive_regulation of RBBP7 1 1 0.25 0 0.87
185 INT201252 Negative_regulation of Binding of USE1 1 1 0.01 0 0.86
186 INT62288 Positive_regulation of ALAD 2 4 0.67 4.27 0.82
187 INT181301 Positive_regulation of NGB 3 1 0.68 2.19 0.82
188 INT201260 Positive_regulation of Positive_regulation of RUVBL1 1 1 0.11 0 0.81
189 INT147433 Gene_expression of BRCA2 1 7 0.62 7.02 0.79
190 INT152527 Negative_regulation of ME1 1 2 0.05 0.6 0.79
191 INT173422 Gene_expression of ETFDH 3 11 0.45 5.78 0.78
192 INT177933 Positive_regulation of MAP3K1 1 6 0.42 4.13 0.76
193 INT193805 Negative_regulation of Gene_expression of ITIH4 2 3 0.42 3.98 0.76
194 INT201253 Positive_regulation of GDI2 1 1 0.27 0 0.76
195 INT178293 Positive_regulation of Gene_expression of Hps1 3 4 0.19 1.79 0.73
196 INT181306 Regulation of Gene_expression of NGB 1 1 0.44 0.7 0.73
197 INT201258 Positive_regulation of GNB2L1 1 1 0.26 0 0.72
198 INT201257 Positive_regulation of VAPA 1 1 0.01 0 0.71
199 INT140637 Negative_regulation of IFI27 1 11 0.40 9.48 0.69
200 INT181299 Localization of NGB 2 1 0.73 1.82 0.69
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