J:Res. Commun. Chem. Pathol. Pharmacol.

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This page displays the top molecular interactions and top single events that were mentioned in the literature in this journal. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported in this journal. They are ordered first by their pain relevance and then by number of times they were reported in this journal. Text mining (TM) confidence, disease relevance and pain relevance are highlighted in green if they are judged to be high and red if not. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Reported in Journal Documents TM Confidence Disease Relevance Pain Relevance
1 INT38161 Binding of Caf and Ack 1 2 0.21 0.52 2.23
2 INT18139 Binding of Penk and Stmn1 1 1 0.08 0 0.99
3 INT1654 Pomc Regulation of DSP 1 1 0.03 0 0.94
4 INT57356 Sct Positive_regulation of Pomc 1 2 0.41 0.2 0.45
5 INT2428 Pag1 Regulation of Kitl 1 1 0.00 0.41 0.38
6 INT41787 IFNA2 Negative_regulation of Glb1 1 1 0.04 0.09 0.23
7 INT21576 NT5C3 Negative_regulation of Gene_expression of TIMP1 1 1 0.03 0.25 0.2
8 INT21577 IL4I1 Positive_regulation of Gene_expression of TIMP1 1 1 0.11 0.24 0.19
9 INT21578 NT5C3 Regulation of Gene_expression of IL4I1 1 1 0.01 0.24 0.19

Single Events

The table below shows the top 100 pain related interactions that have been reported in this journal. They are ordered first by their pain relevance and then by number of times they were reported in this journal. Text mining (TM) confidence, disease relevance and pain relevance are highlighted in green if they are judged to be high and red if not. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Reported in Journal Documents TM Confidence Disease Relevance Pain Relevance
1 INT796 Gene_expression of Penk 2 1902 0.78 275.47 1057.59
2 INT292 Localization of Penk 1 876 0.81 88.44 669.14
3 INT728 Positive_regulation of Penk 1 1068 0.70 186.9 636.87
4 INT155 Positive_regulation of Prl 1 1233 0.70 317.93 457.82
5 INT1045 Localization of LH 3 1211 0.81 87.04 456.25
6 INT467 Gene_expression of POMC 1 1048 0.78 332.8 394.16
7 INT1395 Negative_regulation of Penk 1 537 0.59 87.33 389.81
8 INT5660 Binding of Oprd1 1 477 0.48 71.86 342.06
9 INT162 Regulation of Prl 1 794 0.62 165.01 322.24
10 INT886 Gene_expression of Pomc 1 676 0.78 129.87 295.98
11 INT1396 Binding of Penk 8 355 0.48 22.79 269.65
12 INT738 Regulation of POMC 1 459 0.62 111.19 243.74
13 INT1212 Binding of Oprl1 5 312 0.48 28.6 225.15
14 INT1652 Regulation of Pomc 1 387 0.62 61.01 186.51
15 INT12602 Negative_regulation of Oprm1 1 190 0.59 36.11 177.85
16 INT1429 Gene_expression of PDYN 1 308 0.78 61.33 175.65
17 INT739 Negative_regulation of POMC 1 358 0.59 102.28 166.77
18 INT1114 Localization of Ins1 1 748 0.80 192.95 165.48
19 INT5513 Negative_regulation of Pomc 1 295 0.59 60.9 158.63
20 INT2640 Gene_expression of Pomc 4 424 0.78 120.72 155.37
21 INT1044 Negative_regulation of Localization of LH 1 358 0.59 25.95 151.31
22 INT9852 Positive_regulation of Gpt 5 563 0.70 364.64 146.82
23 INT5061 Negative_regulation of Mme 1 306 0.59 51.97 136.9
24 INT2106 Regulation of Localization of LH 1 279 0.62 22.37 122.77
25 INT5010 Gene_expression of Calca 1 197 0.78 85.76 118.75
26 INT8413 Gene_expression of Ptgs1 1 248 0.78 110.17 108.58
27 INT114 Binding of Oprl1 1 139 0.48 23 103.35
28 INT293 Protein_catabolism of Penk 2 161 1.00 11.71 98.45
29 INT940 Negative_regulation of Ptgs1 2 219 0.59 104.34 95.97
30 INT1004 Regulation of Sst 1 140 0.62 18.52 94.84
31 INT203 Positive_regulation of Pomc 7 257 0.70 90.56 92.84
32 INT1281 Negative_regulation of Maoa 1 203 0.59 22.47 91.66
33 INT339 Regulation of Trh 1 156 0.62 39.27 83.55
34 INT6107 Localization of Npy 1 180 0.81 26.76 81.67
35 INT3214 Localization of Ins1 2 527 0.80 196.9 79.26
36 INT1335 Negative_regulation of Oprl1 1 123 0.59 18.02 77.13
37 INT39565 Gene_expression of Ptger2 1 424 0.75 229.28 72.68
38 INT8363 Localization of Nts 1 135 0.81 14.29 61.71
39 INT1169 Negative_regulation of Bche 1 322 0.59 149.22 61.27
40 INT1437 Negative_regulation of Pomc 2 132 0.59 35.22 60.97
41 INT1430 Regulation of PDYN 1 88 0.60 16.99 60.32
42 INT1759 Gene_expression of TIMP1 2 267 0.77 133.87 59.29
43 INT3920 Localization of Ldha 1 241 0.81 83.08 58.72
44 INT18883 Negative_regulation of RYBP 1 53 0.56 21.14 57.52
45 INT5338 Regulation of Npy 2 92 0.62 25.54 51.24
46 INT1232 Positive_regulation of Pdpk1 2 78 0.42 24.33 50.17
47 INT375 Positive_regulation of REN 2 293 0.70 152.46 47.55
48 INT2275 Negative_regulation of Localization of Ins1 1 183 0.59 51.02 44.94
49 INT28265 Positive_regulation of Calca 1 62 0.70 29.1 41.17
50 INT115 Negative_regulation of Maoa 7 65 0.59 16.27 38.66
51 INT3216 Positive_regulation of Localization of Ins1 1 170 0.69 56.78 35.63
52 INT8747 Positive_regulation of Ins1 1 221 0.69 154.28 35.15
53 INT7608 Positive_regulation of Adra2a 2 66 0.70 17.81 35.15
54 INT692 Negative_regulation of SST 1 72 0.59 28.68 34.52
55 INT1457 Negative_regulation of Binding of Penk 5 40 0.57 0.25 34.24
56 INT608 Negative_regulation of KNG1 1 98 0.43 72.36 31.23
57 INT6277 Positive_regulation of Gene_expression of Pomc 1 76 0.70 21.45 31.09
58 INT1179 Negative_regulation of Ace 1 157 0.59 67.03 30.46
59 INT6364 Gene_expression of Edn1 3 123 0.78 73.76 28.43
60 INT22499 Regulation of Calca 1 42 0.62 17.32 28.02
61 INT3076 Regulation of KNG1 2 52 0.60 20.39 27.89
62 INT7717 Positive_regulation of Adra2a 1 62 0.70 17.68 27.32
63 INT3217 Regulation of Ins1 2 154 0.62 87.11 27.29
64 INT47075 Positive_regulation of Ptger2 1 142 0.70 78.55 25.47
65 INT15390 Positive_regulation of Edn1 1 64 0.70 47.36 23.8
66 INT18323 Negative_regulation of Localization of Ins1 2 122 0.58 45.74 23.04
67 INT1334 Negative_regulation of Binding of Oprl1 1 29 0.59 3.03 20.62
68 INT45840 Positive_regulation of Gene_expression of Ptgs1 1 35 0.50 16.07 20.49
69 INT14701 Negative_regulation of IFNA1 1 118 0.54 84.19 20.08
70 INT7994 Gene_expression of Lta 2 113 0.67 69.81 19.59
71 INT6807 Regulation of Gabrd 1 39 0.62 9.22 18.74
72 INT1060 Negative_regulation of Pla2g1b 1 50 0.57 22.91 18.12
73 INT1533 Negative_regulation of AGT 1 105 0.42 46.54 16.92
74 INT4853 Regulation of Hrh2 1 42 0.45 22.34 16.65
75 INT18527 Localization of Aap 3 31 0.72 5.6 14.42
76 INT12231 Positive_regulation of Localization of Nts 1 17 0.70 4.54 13.85
77 INT7997 Gene_expression of Ltc4s 1 51 0.76 34.28 13.8
78 INT22000 Positive_regulation of Sst 2 25 0.70 14.82 13.6
79 INT2396 Regulation of Maoa 3 25 0.62 6.04 13.27
80 INT10585 Localization of NAGLU 2 53 0.80 23.32 12.75
81 INT44 Positive_regulation of Adra1a 1 30 0.68 7.09 12.73
82 INT787 Localization of Ptgs1 1 31 0.80 12.36 11.55
83 INT152 Negative_regulation of MBD2 1 31 0.38 3.95 11.31
84 INT2260 Gene_expression of Tyr 1 30 0.49 7.05 11.31
85 INT3845 Gene_expression of GSR 1 79 0.76 44.69 11.19
86 INT11649 Negative_regulation of Positive_regulation of Gpt 4 25 0.59 13.94 10.87
87 INT1459 Positive_regulation of Binding of Penk 3 15 0.67 0.08 10.45
88 INT3846 Positive_regulation of GSR 2 60 0.50 35.16 9.37
89 INT3703 Negative_regulation of Grhpr 1 38 0.50 11.43 9.2
90 INT5458 Negative_regulation of Tbxa2r 1 31 0.54 10.58 8.89
91 INT12095 Negative_regulation of Edn1 1 26 0.59 12.01 8.79
92 INT12975 Regulation of PLEK 1 21 0.60 13.62 8.28
93 INT44537 Positive_regulation of Comt 2 7 0.69 2.62 7.78
94 INT13675 Gene_expression of Cyp2c22 1 23 0.39 4.52 7.71
95 INT113 Positive_regulation of MBD2 2 33 0.49 6.76 7.49
96 INT7743 Binding of Hrh2 1 19 0.47 7.75 7.11
97 INT1973 Positive_regulation of NAGLU 1 36 0.65 14.78 7
98 INT21579 Negative_regulation of Gene_expression of TIMP1 1 25 0.57 12.41 6.94
99 INT23132 Positive_regulation of Pnmt 1 17 0.67 2.02 6.84
100 INT49506 Regulation of Ptger2 1 29 0.44 17.38 6.75
101 INT127 Positive_regulation of ACOT1 1 16 0.32 5.12 6.57
102 INT6097 Negative_regulation of NEUROD1 1 30 0.57 9.71 6.24
103 INT24504 Localization of Anpep 2 19 0.80 3.44 6.23
104 INT36560 Binding of Selenbp2 1 6 0.19 1.42 6.07
105 INT13607 Binding of Ack 5 11 0.36 5.77 6.01
106 INT60032 Negative_regulation of Pla2g2a 1 29 0.58 12.42 5.75
107 INT22943 Positive_regulation of Positive_regulation of Gpt 2 23 0.47 16.09 5.55
108 INT38160 Binding of Caf 4 6 0.37 3 5.1
109 INT10605 Positive_regulation of Ltc4s 1 21 0.68 17.22 4.8
110 INT21582 Regulation of Gene_expression of TIMP1 1 20 0.61 12.39 4.77
111 INT1841 Negative_regulation of Hrasls 1 15 0.48 6.85 4.56
112 INT4683 Negative_regulation of PDXK 3 17 0.55 12.81 4.39
113 INT4134 Negative_regulation of Glce 1 11 0.58 2.97 4.28
114 INT387 Regulation of Ace 1 18 0.45 5.24 4.24
115 INT12182 Binding of Mttp 1 6 0.10 1.29 3.97
116 INT2397 Gene_expression of Maoa 1 12 0.77 11.85 3.88
117 INT20743 Positive_regulation of Gene_expression of Ltc4s 1 13 0.60 12.3 3.86
118 INT3842 Positive_regulation of Gsr 1 14 0.69 3.48 3.55
119 INT37110 Positive_regulation of Ptgfr 2 10 0.69 2.38 3.44
120 INT4545 Negative_regulation of Nox1 4 15 0.53 10.08 3.4
121 INT45324 Positive_regulation of Otc 1 8 0.59 3.94 3.36
122 INT3919 Localization of Got1 1 10 0.71 2.95 3.28
123 INT18135 Regulation of Stmn1 1 2 0.17 0.15 3.24
124 INT22944 Regulation of Grhpr 1 12 0.26 0.78 3
125 INT1653 Positive_regulation of DSP 1 8 0.49 3.3 2.93
126 INT45971 Negative_regulation of GOT1 1 9 0.51 6.2 2.84
127 INT51377 Localization of Hexb 2 10 0.80 3.02 2.8
128 INT57354 Positive_regulation of Positive_regulation of Calca 1 3 0.60 1.42 2.78
129 INT19177 Negative_regulation of GRHPR 3 19 0.53 12.65 2.71
130 INT21248 Localization of Lta 1 15 0.59 5.16 2.5
131 INT13626 Positive_regulation of Ap2m1 1 5 0.49 0.94 2.47
132 INT10612 Localization of NLRP3 1 13 0.78 8.91 2.27
133 INT33394 Negative_regulation of esterase 1 10 0.57 1.57 2.06
134 INT35745 Negative_regulation of AGL 1 29 0.50 9.16 2.03
135 INT24453 Binding of NLRP3 1 18 0.48 13.7 1.93
136 INT12849 Negative_regulation of Atp6v0a1 1 5 0.51 0.64 1.89
137 INT23426 Regulation of ADRA2A 1 8 0.48 1.81 1.88
138 INT35008 Regulation of ES-J995 1 5 0.45 1.7 1.68
139 INT19342 Regulation of Insr 2 12 0.24 6.11 1.54
140 INT2316 Positive_regulation of Ugt1a5 3 5 0.67 0.84 1.52
141 INT12429 Negative_regulation of Spdya 2 5 0.20 1.07 1.49
142 INT54805 Regulation of Ahr 1 7 0.22 4.14 1.41
143 INT21581 Gene_expression of IL4I1 1 9 0.24 4.21 1.37
144 INT20244 Regulation of B3gat1 1 7 0.38 0.99 1.32
145 INT31425 Localization of Ptgfr 5 10 0.81 0.92 1.31
146 INT4682 Positive_regulation of EGOT 1 2 0.42 2.32 1.28
147 INT38791 Localization of Ack 1 1 0.59 0.33 1.03
148 INT12976 Negative_regulation of ADRA2A 1 4 0.50 0.16 1.01
149 INT37981 Negative_regulation of Ack 1 1 0.37 0.07 1.01
150 INT22946 Gene_expression of MBD2 1 4 0.25 0.26 0.98
151 INT37109 Negative_regulation of Localization of Ptgfr 3 4 0.59 0.35 0.88
152 INT6806 Localization of Tspo 1 3 0.70 0 0.82
153 INT45319 Binding of Gsta 2 3 0.05 1.36 0.79
154 INT29869 Localization of Metap1d 1 2 0.61 0 0.78
155 INT2317 Gene_expression of Ugt1a5 1 2 0.58 0.35 0.68
156 INT7609 Regulation of Positive_regulation of Adra2a 1 3 0.32 0.59 0.66
157 INT42631 Negative_regulation of AHRR 1 2 0.01 0.44 0.56
158 INT22945 Regulation of Pdia3 1 4 0.26 0.56 0.5
159 INT43459 Positive_regulation of Positive_regulation of Ltc4s 1 2 0.11 2.47 0.5
160 INT37108 Positive_regulation of Localization of Ptgfr 2 1 0.50 0.25 0.48
161 INT4132 Binding of Slc10a3 3 5 0.38 0.15 0.46
162 INT6808 Localization of Zeb1 1 2 0.18 0 0.45
163 INT44379 Positive_regulation of CHPF 1 1 0.01 0 0.45
164 INT46155 Binding of Ephx1 1 2 0.28 0.16 0.43
165 INT46156 Regulation of Binding of Ephx1 1 1 0.34 0.09 0.43
166 INT45318 Negative_regulation of Gsta 1 1 0.06 0.23 0.38
167 INT45323 Binding of Atp6v0a1 1 1 0.18 0.23 0.37
168 INT47175 Negative_regulation of Negative_regulation of AGL 1 4 0.24 1.19 0.36
169 INT4133 Binding of Npc1 1 14 0.47 8.24 0.33
170 INT3959 Regulation of Lipg 1 6 0.27 2.48 0.29
171 INT4546 Negative_regulation of EIF2C2 3 1 0.57 1.14 0.25
172 INT47381 Binding of Gss 1 1 0.25 0 0.24
173 INT29590 Positive_regulation of Localization of NLRP3 1 3 0.49 0.51 0.23
174 INT12428 Binding of RGD735065 2 1 0.07 0.3 0.2
175 INT57353 Positive_regulation of Positive_regulation of Sct 1 1 0.44 0.05 0.19
176 INT21580 Negative_regulation of NT5C3 1 1 0.04 0.23 0.19
177 INT57355 Positive_regulation of Sct 1 1 0.44 0.05 0.19
178 INT6838 Binding of Atp2b4 1 4 0.08 0.8 0.18
179 INT6843 Gene_expression of RPL7AP22 1 1 0.00 0 0.18
180 INT6841 Gene_expression of C7orf23 1 1 0.00 0 0.18
181 INT47317 Negative_regulation of EGOT 1 1 0.41 0.17 0.17
182 INT6844 Positive_regulation of IGHVIV-44-1 1 1 0.00 0 0.17
183 INT6842 Regulation of Positive_regulation of IGHVIV-44-1 1 1 0.00 0 0.17
184 INT6837 Positive_regulation of Binding of Atp2b4 1 1 0.00 0 0.14
185 INT43457 Positive_regulation of Localization of Lta 1 1 0.07 0.07 0.07
186 INT43460 Positive_regulation of Gene_expression of Nfil3 1 1 0.00 0 0
187 INT43458 Gene_expression of Nfil3 1 1 0.00 0 0
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