J:Rheumatology (Oxford, England)

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This page displays the top molecular interactions and top single events that were mentioned in the literature in this journal. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported in this journal. They are ordered first by their pain relevance and then by number of times they were reported in this journal. Text mining (TM) confidence, disease relevance and pain relevance are highlighted in green if they are judged to be high and red if not. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Reported in Journal Documents TM Confidence Disease Relevance Pain Relevance
1 INT278292 Binding of CRP and ESR1 6 3 0.09 10.92 0.96
2 INT203101 Binding of Aes and Mtx1 2 1 0.25 0.24 0.88
3 INT239501 Binding of Adora2a and Mtx1 1 2 0.24 0.95 0.64
4 INT239488 Spna1 Negative_regulation of Gene_expression of Timp1 1 1 0.00 0.94 0.62
5 INT122096 Binding of HLA-B and SFTPA1 2 1 0.04 1.81 0.6
6 INT239489 Spna1 Negative_regulation of Timp1 1 1 0.00 0.89 0.57
7 INT239500 Binding of Aes and Atic 1 1 0.20 0.4 0.56
8 INT269061 Binding of Il6 and Il6ra 3 1 0.04 2.59 0.45
9 INT349289 Binding of SPATA19 and SFTPA1 1 1 0.03 1.2 0.4
10 INT349290 Binding of HLA-B and SPATA19 1 1 0.00 1.25 0.4
11 INT239503 Binding of Adora2a and Aes 1 3 0.24 0.85 0.35
12 INT289246 Il6 Positive_regulation of Gopc 1 1 0.06 1 0.22
13 INT276968 Il6 Positive_regulation of Gene_expression of Stat3 2 1 0.20 1.54 0.21
14 INT289251 Ptpn11 Regulation of Il6 1 1 0.09 0.86 0.18
15 INT289241 Cish Regulation of Il6 1 1 0.03 0.85 0.18
16 INT289245 Binding of Il6ra and Positive_regulation of Gene_expression of Ptger2 1 1 0.00 0.82 0.15
17 INT289255 Il6 Positive_regulation of Gene_expression of VEGFA 1 1 0.06 1.3 0.15
18 INT289256 Il6 Positive_regulation of VEGFA 1 1 0.05 1.3 0.15
19 INT289248 Il6 Positive_regulation of Gene_expression of Il21 1 1 0.06 0.69 0.15
20 INT289247 Ptger2 Positive_regulation of Gene_expression of Tnfrsf11a 1 1 0.00 0.76 0.14
21 INT289253 Il23a Positive_regulation of Stat3 1 1 0.04 0.37 0.12
22 INT289249 Il6 Regulation of Gene_expression of Ptger2 1 1 0.01 0.77 0.1
23 INT289242 Il6 Positive_regulation of Gene_expression of Prtn3 1 1 0.00 0.5 0.09
24 INT289254 Il6 Regulation of Gene_expression of VEGFA 1 1 0.05 1.32 0.09
25 INT289243 Il6 Positive_regulation of Prtn3 1 1 0.00 0.5 0.09
26 INT289257 Il6 Regulation of VEGFA 1 1 0.03 1.27 0.09
27 INT289258 Binding of ABCA1 and Il6ra 1 1 0.00 0.33 0.07
28 INT289244 Binding of Il11ra1 and Il6ra 1 1 0.01 0.33 0.07
29 INT289252 Il6 Negative_regulation of Tnfrsf11a 1 1 0.11 0.82 0.04
30 INT289250 Il6 Positive_regulation of Gene_expression of Timp1 1 1 0.11 0.64 0.03
31 INT150957 STK16 Positive_regulation of Positive_regulation of NFKB1 1 1 0.04 0.08 0
32 INT239502 Binding of Emp2 and Aes 1 1 0.14 0.06 0

Single Events

The table below shows the top 100 pain related interactions that have been reported in this journal. They are ordered first by their pain relevance and then by number of times they were reported in this journal. Text mining (TM) confidence, disease relevance and pain relevance are highlighted in green if they are judged to be high and red if not. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Reported in Journal Documents TM Confidence Disease Relevance Pain Relevance
1 INT6483 Gene_expression of TNF 11 3152 0.78 2515.62 929.82
2 INT5235 Negative_regulation of TNF 12 924 0.59 772.91 331.98
3 INT5235 Negative_regulation of TNF 1 924 0.59 772.91 331.98
4 INT5059 Positive_regulation of TNF 2 1050 0.70 896.51 322.81
5 INT9659 Gene_expression of Il6 17 991 0.78 715.11 265.57
6 INT68684 Gene_expression of VEGFA 8 2371 0.78 1742.52 259.2
7 INT626 Localization of CALCA 2 289 0.81 125.39 221.15
8 INT6481 Binding of TNF 1 624 0.48 510.2 214.82
9 INT66280 Gene_expression of Nos2 2 534 0.78 330.78 157.07
10 INT15515 Positive_regulation of Crp 3 700 0.70 604.24 150.15
11 INT9660 Regulation of TNF 3 363 0.62 312.94 139.99
12 INT1878 Binding of HLA-B 2 440 0.48 321.16 127.36
13 INT1878 Binding of HLA-B 9 440 0.48 321.16 127.36
14 INT8243 Positive_regulation of Il6 6 451 0.70 358.24 119.28
15 INT17612 Gene_expression of CRP 4 676 0.78 580.61 119.03
16 INT17612 Gene_expression of CRP 1 676 0.78 580.61 119.03
17 INT118381 Gene_expression of Il17a 2 405 0.76 306.97 112.06
18 INT90091 Gene_expression of GOPC 1 967 0.67 366.22 103.6
19 INT77435 Positive_regulation of Nos2 2 343 0.70 208.49 91.43
20 INT54571 Positive_regulation of NFKB1 3 263 0.70 138.99 87.32
21 INT68682 Positive_regulation of VEGFA 1 640 0.70 454.14 81.65
22 INT749 Gene_expression of HLA-B 1 341 0.75 224.12 77.37
23 INT749 Gene_expression of HLA-B 9 341 0.75 224.12 77.37
24 INT62374 Gene_expression of NGF 9 158 0.78 77.87 76.45
25 INT39565 Gene_expression of Ptger2 2 424 0.75 229.28 72.68
26 INT79494 Positive_regulation of Gene_expression of VEGFA 3 577 0.70 442.94 69.73
27 INT5374 Gene_expression of Esr1 2 412 0.77 263.89 67.34
28 INT5374 Gene_expression of Esr1 2 412 0.77 263.89 67.34
29 INT9489 Gene_expression of SFTPA1 4 112 0.66 55.38 66.45
30 INT11937 Localization of Il6 4 228 0.81 139.83 64.39
31 INT822 Gene_expression of ESR1 1 529 0.78 302.16 63.64
32 INT9657 Positive_regulation of Gene_expression of Il6 3 237 0.70 180.45 63.6
33 INT48232 Gene_expression of MMP1 7 245 0.78 96.31 57.72
34 INT117598 Regulation of ACR 7 118 0.26 41.25 48.01
35 INT3361 Positive_regulation of Esr1 1 273 0.69 208.53 44.81
36 INT80124 Negative_regulation of VEGFA 1 450 0.58 311.19 44.53
37 INT157666 Positive_regulation of GOPC 2 335 0.60 120.19 42.75
38 INT4004 Gene_expression of IGHG3 1 321 0.71 221.03 42.33
39 INT13556 Gene_expression of CD4 1 367 0.78 230.82 41.74
40 INT11939 Negative_regulation of Il6 4 138 0.59 87.46 41.24
41 INT97596 Localization of S100a8 2 94 0.78 90.69 40.41
42 INT52732 Negative_regulation of CRP 1 169 0.59 138.47 40.33
43 INT77434 Positive_regulation of Gene_expression of Nos2 1 151 0.69 96.76 38.94
44 INT8835 Localization of SFTPA1 1 65 0.68 32.81 38.65
45 INT163134 Gene_expression of ACR 1 78 0.65 30.39 38.48
46 INT9082 Positive_regulation of ESR1 1 238 0.69 148.51 36.69
47 INT12892 Negative_regulation of TIMP1 1 136 0.58 83.13 36.54
48 INT101992 Localization of VEGFA 1 413 0.81 258.23 36.15
49 INT9655 Regulation of Il6 1 98 0.62 70.92 31.95
50 INT48693 Regulation of VEGFA 1 268 0.62 191.88 31.52
51 INT145594 Gene_expression of Mtx1 16 64 0.57 35.33 30.35
52 INT37296 Binding of Esr1 2 117 0.43 62.51 27.33
53 INT59449 Negative_regulation of Timp1 2 76 0.42 54.86 26.99
54 INT100861 Binding of CRP 2 179 0.48 175.2 26.45
55 INT19856 Gene_expression of CD8A 1 240 0.75 147.86 26.39
56 INT58192 Positive_regulation of MRI1 1 86 0.61 53.81 24.68
57 INT86295 Gene_expression of Mmp2 1 114 0.76 73.68 24.25
58 INT72370 Gene_expression of Timp1 3 82 0.65 57.52 24.16
59 INT823 Negative_regulation of ESR1 1 144 0.58 63.72 22.52
60 INT48692 Binding of VEGFA 1 345 0.48 210.3 21.31
61 INT11346 Binding of Mtx1 6 39 0.41 24.88 21.21
62 INT49985 Transcription of Il6 1 62 0.72 40.13 20.29
63 INT93663 Positive_regulation of MMP1 1 72 0.67 33.38 19.86
64 INT9552 Positive_regulation of TNNI3 2 209 0.70 128.67 19.15
65 INT3952 Negative_regulation of ALB 1 116 0.59 72.18 18.35
66 INT4067 Negative_regulation of Esr1 1 97 0.50 43.45 17.52
67 INT17237 Regulation of Esr1 1 74 0.43 49.09 17.25
68 INT20216 Localization of NGF 3 40 0.80 18.16 16.61
69 INT84924 Positive_regulation of Gene_expression of NGF 4 29 0.68 17.91 16.46
70 INT171666 Regulation of GOPC 2 117 0.39 40.41 15.47
71 INT54572 Negative_regulation of Positive_regulation of NFKB1 1 46 0.58 21.45 15.47
72 INT129584 Positive_regulation of Stat3 1 97 0.68 87.07 14.86
73 INT3545 Positive_regulation of Mtx1 3 27 0.42 11.97 14.83
74 INT71150 Binding of NGF 1 22 0.46 13.67 14.81
75 INT92823 Positive_regulation of Gene_expression of MMP1 3 65 0.68 25.69 14.31
76 INT108063 Gene_expression of Adora2a 2 29 0.78 13.11 13.78
77 INT2038 Localization of Esr1 1 104 0.79 40.12 13.27
78 INT39564 Negative_regulation of Gene_expression of Ptger2 1 50 0.42 30.9 12.97
79 INT54763 Binding of Il6 8 82 0.48 63.27 12.89
80 INT24876 Gene_expression of CD34 1 172 0.78 91.02 12.39
81 INT92686 Gene_expression of Ctgf 3 51 0.77 34.4 11.93
82 INT21850 Gene_expression of Spna1 14 107 0.50 51.4 11.81
83 INT102272 Regulation of TH1L 1 41 0.44 30.89 11.63
84 INT37541 Gene_expression of SPP1 4 113 0.77 68.54 11.35
85 INT11936 Positive_regulation of Positive_regulation of Il6 1 34 0.50 26.85 10.59
86 INT94454 Gene_expression of CD68 1 73 0.72 63.94 10.43
87 INT103554 Positive_regulation of MTX1 1 19 0.45 11.23 10
88 INT140338 Negative_regulation of Gene_expression of Il17a 1 34 0.46 23.82 9.87
89 INT114874 Gene_expression of Stat3 2 78 0.76 53.99 9.49
90 INT137400 Regulation of Mtx1 1 16 0.52 9.19 9.45
91 INT35269 Localization of SGCG 1 38 0.78 14.68 9.01
92 INT22285 Negative_regulation of Mtx1 3 16 0.49 7.84 8.98
93 INT26795 Gene_expression of Mtpn 1 44 0.62 27.66 8.62
94 INT96068 Positive_regulation of Timp1 1 30 0.58 23.94 8.17
95 INT24232 Localization of Mtx1 1 24 0.65 8.06 7.99
96 INT171962 Gene_expression of Tnfrsf11a 1 40 0.72 31.1 7.84
97 INT74520 Positive_regulation of CD68 1 30 0.61 31.68 7.59
98 INT153300 Negative_regulation of Gene_expression of CRP 1 48 0.58 39.97 7.58
99 INT122901 Positive_regulation of Spp1 1 67 0.67 58.03 7.49
100 INT224648 Gene_expression of Il21 1 15 0.39 18.71 7.47
101 INT115213 Regulation of SFTPA1 1 13 0.32 6.91 7.11
102 INT66210 Regulation of Positive_regulation of NFKB1 2 16 0.60 9.46 7.08
103 INT36960 Gene_expression of vs 1 33 0.43 20.77 6.97
104 INT23782 Positive_regulation of Spna1 3 58 0.50 35.41 6.94
105 INT95117 Gene_expression of PDGFA 2 71 0.71 51.17 6.9
106 INT8541 Gene_expression of Csrp1 1 42 0.76 23.72 6.9
107 INT8541 Gene_expression of Csrp1 4 42 0.76 23.72 6.9
108 INT8799 Negative_regulation of Csrp1 1 24 0.58 11.01 6.86
109 INT3795 Positive_regulation of Ighm 1 46 0.68 22.43 6.47
110 INT95607 Regulation of MMP1 1 19 0.60 7.86 6.18
111 INT50050 Gene_expression of CSRP1 1 23 0.76 16.84 5.86
112 INT43997 Positive_regulation of Gene_expression of Esr1 1 57 0.51 36.66 5.51
113 INT88935 Positive_regulation of SPP1 2 36 0.70 31.07 5.49
114 INT62510 Positive_regulation of MCS 1 32 0.60 11.79 5.45
115 INT163913 Gene_expression of Il11ra1 2 18 0.69 12.62 5.34
116 INT83014 Binding of Adora2a 2 13 0.48 5.57 5.33
117 INT66423 Binding of ELOVL1 4 52 0.40 61.63 5.16
118 INT67144 Gene_expression of Cd44 2 17 0.76 8.94 4.48
119 INT129964 Negative_regulation of MMP13 2 23 0.55 6.48 4.21
120 INT139533 Binding of Il23r 1 17 0.47 7.67 4.14
121 INT216851 Binding of IGKV2D-29 1 8 0.36 1.56 3.93
122 INT66924 Positive_regulation of Transcription of Il6 1 18 0.68 11.8 3.53
123 INT19491 Gene_expression of CD19 1 44 0.75 28.8 3.47
124 INT92681 Positive_regulation of Ctgf 2 13 0.69 9.78 3.47
125 INT113604 Negative_regulation of Gene_expression of Ctgf 2 19 0.58 9.37 3.43
126 INT3824 Negative_regulation of PTH 1 40 0.59 28.58 3.39
127 INT22375 Localization of PDGFA 1 21 0.75 15.46 3.25
128 INT227515 Regulation of Gene_expression of Mtx1 1 5 0.38 4.34 3.24
129 INT239495 Negative_regulation of Gene_expression of Mtx1 1 3 0.36 1.55 3.24
130 INT172551 Negative_regulation of INCENP 1 38 0.07 20.83 3.14
131 INT92632 Gene_expression of Vsig2 1 48 0.50 19.93 3.04
132 INT58527 Gene_expression of Prtn3 1 20 0.71 15.99 2.9
133 INT175685 Positive_regulation of Gene_expression of Timp1 1 11 0.57 8.18 2.58
134 INT129961 Regulation of Gene_expression of MMP1 3 15 0.46 4.88 2.51
135 INT77983 Positive_regulation of Gene_expression of Csrp1 1 4 0.19 4.91 2.38
136 INT172078 Localization of Cd3e 1 22 0.37 9.88 2.27
137 INT2544 Localization of PTH 1 39 0.81 30.55 2.22
138 INT163912 Binding of Il11ra1 2 5 0.33 5.06 2.22
139 INT100622 Localization of CD68 1 16 0.73 6.58 2.2
140 INT158459 Negative_regulation of Gene_expression of Timp1 1 8 0.40 4.21 2.16
141 INT57501 Binding of CREM 1 11 0.27 3.67 2.15
142 INT47780 Gene_expression of CREM 1 17 0.74 5.37 2.13
143 INT34579 Localization of IGLL1 1 7 0.69 2.63 1.89
144 INT187492 Positive_regulation of ATIC 1 9 0.05 1.74 1.88
145 INT151039 Binding of Il23r 2 8 0.42 3.01 1.86
146 INT192684 Negative_regulation of vs 1 15 0.19 9.18 1.75
147 INT29833 Binding of Spna1 1 39 0.27 19.4 1.74
148 INT160814 Gene_expression of Il6ra 6 15 0.07 9.61 1.73
149 INT98096 Positive_regulation of CHKA 1 14 0.42 12.23 1.61
150 INT114862 Gene_expression of BEST1 1 16 0.65 12.14 1.53
151 INT88934 Regulation of SPP1 2 9 0.54 6.94 1.47
152 INT152223 Binding of BEST1 1 10 0.29 6.67 1.46
153 INT173716 Positive_regulation of Cd44 1 7 0.44 4.65 1.45
154 INT104250 Positive_regulation of Gene_expression of SPP1 1 17 0.69 13.22 1.44
155 INT92685 Transcription of Ctgf 1 7 0.72 3.92 1.44
156 INT47950 Negative_regulation of ELOVL1 2 15 0.41 20.33 1.41
157 INT232486 Positive_regulation of Gene_expression of Mtx1 1 3 0.42 0.96 1.41
158 INT187156 Binding of CD19 1 10 0.29 2.05 1.2
159 INT158563 Negative_regulation of Ctgf 1 6 0.56 4.31 1.12
160 INT239482 Positive_regulation of Gene_expression of Spna1 4 10 0.41 5.06 1.05
161 INT48944 Binding of Pts 1 8 0.41 3.23 1.03
162 INT20470 Positive_regulation of Acsl1 1 5 0.40 3.76 1.03
163 INT30093 Positive_regulation of Positive_regulation of Spna1 1 8 0.41 4.48 0.95
164 INT239497 Binding of Aes 7 8 0.29 3.61 0.84
165 INT261600 Positive_regulation of Gene_expression of Il6ra 2 7 0.05 6.22 0.84
166 INT51739 Negative_regulation of Apob 1 9 0.42 4.21 0.78
167 INT239499 Positive_regulation of Positive_regulation of ATIC 1 1 0.05 0.53 0.77
168 INT239496 Gene_expression of Aes 2 4 0.52 1.45 0.76
169 INT289232 Localization of Il6ra 2 1 0.06 2.12 0.75
170 INT143445 Protein_catabolism of VEGFA 1 12 0.85 4.14 0.72
171 INT239494 Regulation of Localization of Esr1 1 4 0.19 1.15 0.72
172 INT73977 Gene_expression of Serpinh1 2 14 0.54 8.14 0.69
173 INT338936 Negative_regulation of Localization of Mtx1 1 2 0.30 1.08 0.64
174 INT169725 Binding of Il6ra 3 4 0.07 3.99 0.59
175 INT289237 Positive_regulation of Il6ra 5 1 0.05 3.84 0.59
176 INT270790 Negative_regulation of Binding of CRP 1 5 0.42 2.9 0.55
177 INT214559 Positive_regulation of Gene_expression of CD19 1 4 0.38 1.34 0.54
178 INT169726 Negative_regulation of Il6ra 3 3 0.05 3.14 0.53
179 INT239483 Protein_catabolism of Spna1 1 3 0.11 2.25 0.47
180 INT150960 Positive_regulation of Positive_regulation of MMP1 1 4 0.34 0.85 0.44
181 INT149650 Protein_catabolism of Nos2 1 3 0.55 0.79 0.42
182 INT239498 Localization of Aes 1 2 0.58 2.22 0.4
183 INT295592 Protein_catabolism of COL8A1 1 1 0.01 1.23 0.4
184 INT349291 Binding of SPATA19 1 1 0.03 0.93 0.33
185 INT236270 Binding of Hhex 1 2 0.07 1.55 0.29
186 INT97129 Transcription of SPP1 1 4 0.51 0.67 0.23
187 INT246500 Positive_regulation of Binding of Mtx1 1 1 0.19 0.57 0.22
188 INT289227 Regulation of Gene_expression of Stat3 1 4 0.47 3.66 0.21
189 INT243202 Negative_regulation of YARS 1 1 0.02 0.73 0.19
190 INT289233 Localization of Sh2 1 1 0.11 0.86 0.18
191 INT289228 Localization of Ptpn11 1 1 0.15 0.87 0.18
192 INT145362 Positive_regulation of RORA 1 3 0.49 0.61 0.14
193 INT154340 Binding of IGLL1 1 3 0.02 0.82 0.14
194 INT289225 Positive_regulation of Positive_regulation of Il6ra 1 1 0.04 0.77 0.14
195 INT239485 Regulation of Gene_expression of Serpinh1 1 1 0.02 0.35 0.14
196 INT150959 Gene_expression of BCO2 1 4 0.25 2.21 0.08
197 INT155305 Positive_regulation of Transcription of SPP1 1 2 0.11 0.29 0.04
198 INT330788 Protein_catabolism of Cd3e 1 1 0.07 0 0.04
199 INT236269 Gene_expression of OTSC1 1 1 0.05 0.13 0.03
200 INT236268 Binding of OTSC1 1 1 0.03 0 0
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