J:Semin Immunopathol

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This page displays the top molecular interactions and top single events that were mentioned in the literature in this journal. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported in this journal. They are ordered first by their pain relevance and then by number of times they were reported in this journal. Text mining (TM) confidence, disease relevance and pain relevance are highlighted in green if they are judged to be high and red if not. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Reported in Journal Documents TM Confidence Disease Relevance Pain Relevance
1 INT86180 SFTPA1 Positive_regulation of Localization of IL6 2 1 0.06 2.01 2.85
2 INT229394 TPSD1 Positive_regulation of F2RL1 2 2 0.00 3.11 2.14
3 INT266764 TPSD1 Positive_regulation of F2RL1 Positive_regulation of Localization of SFTPA1 1 1 0.00 1.55 1.76
4 INT266768 NGF Positive_regulation of Localization of SFTPA1 1 1 0.01 1.65 1.6
5 INT266767 SFTPA1 Positive_regulation of Gene_expression of TNF 1 1 0.01 1.69 1.59
6 INT182097 Binding of Il6 and Il1 4 1 0.07 4.67 1.55
7 INT266771 Binding of NGF and GOPC 1 2 0.05 3.23 1.43
8 INT186355 Il23a Positive_regulation of Gene_expression of Il17a 4 1 0.12 3 1.24
9 INT285561 Il23a Positive_regulation of Gene_expression of Il22 2 1 0.06 2.45 0.93
10 INT266769 IL2 Positive_regulation of Localization of IL4 1 1 0.00 1.03 0.72
11 INT266765 IL2 Positive_regulation of Localization of IL10 1 1 0.01 1.03 0.72
12 INT300551 TBX21 Regulation of Hand1 2 1 0.10 0.44 0.48
13 INT300544 Il22 Positive_regulation of Gene_expression of Mcpt1 1 1 0.02 1.15 0.47
14 INT300547 Il6 Positive_regulation of Il21 1 1 0.02 0.78 0.39
15 INT300549 Il1 Regulation of Gene_expression of Irf4 1 1 0.01 0.63 0.33
16 INT266806 Hand2 Regulation of Gene_expression of IL10 1 1 0.00 1.23 0.32
17 INT266804 Hand2 Regulation of Gene_expression of IL13 1 1 0.00 1.23 0.32
18 INT266805 Hand2 Regulation of Gene_expression of IL4 1 1 0.00 1.23 0.32
19 INT266800 Dlst Positive_regulation of Localization of VEGFA 1 1 0.02 0.88 0.29
20 INT300552 Napa Positive_regulation of Gene_expression of TGFB1 1 1 0.01 0.88 0.29
21 INT266766 Binding of PGR and GOPC 1 1 0.00 1.08 0.29
22 INT300548 Napa Positive_regulation of Gene_expression of Il23a 1 1 0.05 0.86 0.28
23 INT266803 Dlst Positive_regulation of VEGFA 1 1 0.01 0.96 0.25
24 INT266802 Dlst Positive_regulation of CCL5 1 1 0.00 0.95 0.25
25 INT300546 Binding of Il23a and Il1 1 1 0.01 0.5 0.25
26 INT266801 Dlst Positive_regulation of IL8 1 1 0.00 0.95 0.25
27 INT283520 Binding of DLAT and Pain1 1 1 0.27 0.65 0.22
28 INT229928 Binding of C3 and CFH 1 1 0.07 1.35 0.17
29 INT229931 Negative_regulation of Binding of C3 and CFH 1 1 0.08 1.35 0.17
30 INT300545 Il6 Positive_regulation of Gene_expression of Il1r1 1 1 0.02 0.42 0.11
31 INT283460 Binding of CTLA4 and DLAT 1 3 0.06 3.14 0.09
32 INT283521 PREB Regulation of Fam89b 1 1 0.00 1.08 0.07
33 INT229977 Binding of amd and Cfb 1 3 0.03 2.78 0.06
34 INT229982 Binding of C3 and amd 1 1 0.02 1.14 0.06
35 INT229985 Binding of C2 and amd 1 2 0.01 1.89 0.06
36 INT283464 Binding of CD4 and DLAT 1 1 0.07 0.69 0.04
37 INT283463 Binding of DLAT and GAGE4 1 1 0.00 1.1 0.03
38 INT283462 Binding of DLAT and HLA-DRB1 1 1 0.07 1.06 0.03
39 INT229983 Binding of CFH and Crp 2 1 0.14 1.48 0
40 INT229927 CD59 Negative_regulation of Binding of ABCA1 1 1 0.01 0 0
41 INT229934 Binding of C3 and GPI 1 1 0.01 0 0
42 INT229923 Binding of ABCA1 and C9 1 1 0.00 0.74 0
43 INT229921 CD55 Negative_regulation of C4B 1 2 0.11 0 0
44 INT229925 Binding of C1S and TRGC1 1 1 0.01 0 0
45 INT229984 Binding of CD59 and Cdca3 1 1 0.03 0.73 0
46 INT229935 YBX1 Negative_regulation of C4B 1 2 0.00 0 0
47 INT229930 C3AR1 Positive_regulation of C3 1 1 0.00 0 0
48 INT229981 Binding of ABCA1 and Cdca3 1 1 0.00 0.74 0
49 INT229922 Binding of C9 and CD59 1 1 0.08 0.72 0
50 INT229924 CD55 Positive_regulation of C4B 1 2 0.12 0 0
51 INT229932 C4B Positive_regulation of C3 1 1 0.07 0 0
52 INT229929 Binding of C4B and CFH 1 1 0.09 0 0
53 INT229920 Binding of C4B and CD55 1 2 0.09 0 0
54 INT229919 GPI Negative_regulation of Binding of C3 and GPI 1 1 0.00 0 0
55 INT283461 Binding of IL2 and SLC4A2 1 1 0.01 0.98 0

Single Events

The table below shows the top 100 pain related interactions that have been reported in this journal. They are ordered first by their pain relevance and then by number of times they were reported in this journal. Text mining (TM) confidence, disease relevance and pain relevance are highlighted in green if they are judged to be high and red if not. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Reported in Journal Documents TM Confidence Disease Relevance Pain Relevance
1 INT6483 Gene_expression of TNF 10 3152 0.78 2515.62 929.82
2 INT443 Localization of POMC 3 1020 0.81 284.52 443.17
3 INT9238 Gene_expression of IL6 5 1575 0.78 1135.66 424.22
4 INT5235 Negative_regulation of TNF 2 924 0.59 772.91 331.98
5 INT5059 Positive_regulation of TNF 1 1050 0.70 896.51 322.81
6 INT6852 Localization of TNF 3 883 0.81 705.95 270.84
7 INT10832 Gene_expression of IL8 2 1050 0.78 698.72 270
8 INT9659 Gene_expression of Il6 6 991 0.78 715.11 265.57
9 INT5972 Gene_expression of IL1B 6 948 0.78 510.91 263.97
10 INT68684 Gene_expression of VEGFA 3 2371 0.78 1742.52 259.2
11 INT626 Localization of CALCA 1 289 0.81 125.39 221.15
12 INT6482 Positive_regulation of Gene_expression of TNF 2 659 0.70 569.88 210
13 INT10194 Positive_regulation of IL6 1 702 0.70 600.62 183.38
14 INT55879 Gene_expression of CCL2 2 421 0.78 240.74 166.02
15 INT5116 Gene_expression of IL2 2 670 0.78 291.13 146.69
16 INT6128 Positive_regulation of Localization of POMC 2 256 0.70 68.77 121.64
17 INT8243 Positive_regulation of Il6 3 451 0.70 358.24 119.28
18 INT9235 Negative_regulation of Gene_expression of TNF 1 346 0.59 252.98 118.61
19 INT12339 Localization of IL8 1 437 0.81 251.87 117.39
20 INT20374 Gene_expression of Il4 1 515 0.76 306.15 114.12
21 INT118381 Gene_expression of Il17a 19 405 0.76 306.97 112.06
22 INT11051 Positive_regulation of Gene_expression of IL6 1 415 0.69 319.21 109.3
23 INT60526 Gene_expression of IL10 1 449 0.78 292.71 107.84
24 INT12082 Localization of IL6 3 365 0.81 241.78 105.78
25 INT90091 Gene_expression of GOPC 4 967 0.67 366.22 103.6
26 INT10838 Positive_regulation of IL8 3 381 0.70 295.51 101.62
27 INT11381 Positive_regulation of IL1B 1 330 0.70 209.31 100.9
28 INT4860 Positive_regulation of CALCA 2 148 0.00 73.35 97.61
29 INT48408 Gene_expression of ICAM1 1 494 0.78 340.08 88.6
30 INT48406 Gene_expression of Icam1 1 277 0.78 238.28 81.71
31 INT62374 Gene_expression of NGF 2 158 0.78 77.87 76.45
32 INT9236 Regulation of Gene_expression of TNF 1 204 0.62 162.66 72.99
33 INT56298 Gene_expression of IL4 2 306 0.78 182.18 72.92
34 INT11380 Negative_regulation of IL1B 2 215 0.59 125.62 72.35
35 INT10837 Positive_regulation of Gene_expression of IL8 1 294 0.70 190.08 70.34
36 INT170332 Gene_expression of IFN1@ 2 477 0.75 275.21 69.65
37 INT6849 Localization of IL1B 2 229 0.81 112.56 69.63
38 INT7534 Gene_expression of Ifng 11 193 0.78 111.02 68.6
39 INT7344 Gene_expression of TAC1 1 132 0.75 35.48 68.26
40 INT9489 Gene_expression of SFTPA1 2 112 0.66 55.38 66.45
41 INT67981 Positive_regulation of CCL2 2 165 0.70 136.84 61.85
42 INT14740 Gene_expression of TGFB1 3 272 0.78 168.48 60.18
43 INT546 Binding of ALB 1 311 0.48 85.98 60.14
44 INT48901 Negative_regulation of IL6 1 186 0.57 136.33 57.87
45 INT48232 Gene_expression of MMP1 2 245 0.78 96.31 57.72
46 INT4509 Gene_expression of IGG 1 426 0.76 293.69 56.64
47 INT78899 Gene_expression of CCL5 2 155 0.77 84.02 55.09
48 INT63975 Positive_regulation of Il10 1 175 0.68 134.13 54.69
49 INT20375 Gene_expression of Hand1 4 213 0.60 148.51 54.53
50 INT22112 Positive_regulation of Localization of TNF 1 164 0.70 115.66 52.18
51 INT72182 Gene_expression of Mcpt1 1 167 0.75 123.7 52.15
52 INT20382 Gene_expression of Hand2 1 211 0.66 142.26 51.05
53 INT6473 Positive_regulation of Gene_expression of IL1B 2 204 0.70 117.23 50.86
54 INT80124 Negative_regulation of VEGFA 5 450 0.58 311.19 44.53
55 INT2774 Binding of Crp 2 241 0.48 195.89 44.39
56 INT2774 Binding of Crp 1 241 0.48 195.89 44.39
57 INT73502 Positive_regulation of IL10 2 154 0.69 124.87 43.5
58 INT25383 Gene_expression of Csf2 1 222 0.76 152.93 43.32
59 INT157666 Positive_regulation of GOPC 7 335 0.60 120.19 42.75
60 INT9233 Negative_regulation of Gene_expression of IL1B 1 114 0.59 56.99 41.82
61 INT13556 Gene_expression of CD4 2 367 0.78 230.82 41.74
62 INT5454 Localization of CRH 4 124 0.79 79.18 41.53
63 INT3758 Gene_expression of ALB 1 326 0.78 184.65 38.75
64 INT8835 Localization of SFTPA1 2 65 0.68 32.81 38.65
65 INT62827 Positive_regulation of ICAM1 2 184 0.70 180.95 36.28
66 INT101992 Localization of VEGFA 6 413 0.81 258.23 36.15
67 INT53577 Negative_regulation of Localization of TNF 1 110 0.59 59.28 35.23
68 INT100733 Positive_regulation of F2RL1 1 62 0.70 59.14 35.22
69 INT72651 Gene_expression of TH1L 1 114 0.75 80.15 35.15
70 INT118343 Positive_regulation of Eae1 1 121 0.39 136.06 34.87
71 INT49214 Gene_expression of Cd4 1 269 0.78 154.22 34.05
72 INT11325 Gene_expression of HLA-E 2 209 0.76 98.05 33.72
73 INT10763 Localization of IL2 1 157 0.80 81.11 33.21
74 INT73498 Gene_expression of IL13 1 117 0.44 83.85 32.26
75 INT7082 Gene_expression of CRH 6 180 0.78 64.66 31.74
76 INT7538 Negative_regulation of IL2 1 95 0.57 47.31 31.7
77 INT29503 Gene_expression of Mmp2 2 95 0.77 56.92 31.68
78 INT13186 Positive_regulation of Il4 1 113 0.68 71.22 31.4
79 INT23435 Positive_regulation of NGF 1 54 0.70 32.41 30.11
80 INT50230 Positive_regulation of Localization of IL6 1 105 0.70 69.21 29.52
81 INT15610 Localization of GOPC 3 223 0.65 68.26 28.7
82 INT3760 Positive_regulation of ALB 1 142 0.70 87.46 26.7
83 INT19856 Gene_expression of CD8A 1 240 0.75 147.86 26.39
84 INT135411 Gene_expression of Il23a 5 76 0.72 72.87 26.15
85 INT43486 Positive_regulation of Ifng 6 52 0.69 32.71 24.77
86 INT6441 Positive_regulation of CRH 4 98 0.69 57.22 24.12
87 INT8836 Positive_regulation of SFTPA1 2 36 0.47 28.37 23.59
88 INT74423 Localization of IL10 1 91 0.80 61.6 22.95
89 INT14731 Positive_regulation of TGFB1 2 78 0.67 52.57 22.23
90 INT71047 Gene_expression of CYP19A1 3 122 0.78 68.78 22.21
91 INT150022 Positive_regulation of Il17a 7 69 0.64 70.04 21.87
92 INT74682 Positive_regulation of Mmp2 1 72 0.69 40.46 21.73
93 INT160564 Gene_expression of Il22 9 64 0.55 59.29 20.9
94 INT63340 Positive_regulation of Gene_expression of ICAM1 1 109 0.70 90.82 20.61
95 INT62042 Positive_regulation of Gene_expression of IL4 1 67 0.56 42.05 20.39
96 INT182031 Gene_expression of Cia1 1 38 0.24 46.37 19.64
97 INT756 Gene_expression of C3 4 138 0.75 100.6 19.2
98 INT192409 Positive_regulation of Gene_expression of IFN1@ 1 102 0.67 64.66 18.8
99 INT56301 Positive_regulation of IL4 2 68 0.56 54.51 18.65
100 INT35086 Positive_regulation of Gene_expression of Ifng 3 40 0.69 22.55 18.35
101 INT14724 Negative_regulation of CYP19A1 1 233 0.59 96.56 18.26
102 INT9656 Regulation of Gene_expression of Il6 1 57 0.62 33.3 17.71
103 INT2120 Gene_expression of CD79A 1 159 0.78 111.69 17.16
104 INT24209 Negative_regulation of Ifng 1 37 0.57 16.52 17.15
105 INT84924 Positive_regulation of Gene_expression of NGF 1 29 0.68 17.91 16.46
106 INT170754 Localization of IFN1@ 1 121 0.78 66.78 15.6
107 INT171666 Regulation of GOPC 1 117 0.39 40.41 15.47
108 INT153776 Positive_regulation of IL17A 1 42 0.64 34.58 14.82
109 INT71150 Binding of NGF 2 22 0.46 13.67 14.81
110 INT25493 Gene_expression of TFPI 2 74 0.76 39.44 14.78
111 INT92823 Positive_regulation of Gene_expression of MMP1 1 65 0.68 25.69 14.31
112 INT16321 Gene_expression of Cd3e 1 111 0.72 49.9 14.21
113 INT17035 Positive_regulation of TFPI 2 55 0.61 34.88 14.18
114 INT161515 Positive_regulation of Gene_expression of Il17a 2 50 0.64 41.52 13.82
115 INT18773 Localization of ALB 1 117 0.80 69.18 13.8
116 INT3796 Gene_expression of Ighm 1 130 0.77 69.61 13.78
117 INT56651 Binding of HLA-DRB1 1 58 0.48 52.25 13.68
118 INT173505 Localization of Hand2 1 63 0.57 45.32 13.66
119 INT11699 Binding of HLA-E 1 85 0.47 52.51 13.41
120 INT99586 Binding of IRF6 1 60 0.36 27.87 13.2
121 INT46619 Gene_expression of CSF1 3 80 0.73 36.63 12.94
122 INT27242 Gene_expression of PGR 9 153 0.75 98.77 12.79
123 INT122812 Gene_expression of SNRNP70 1 130 0.75 67 12.5
124 INT5452 Regulation of CRH 1 56 0.62 15.32 12.42
125 INT11288 Negative_regulation of CRH 2 44 0.00 16.69 12.37
126 INT176453 Negative_regulation of Cia1 1 23 0.14 28.27 12.33
127 INT148207 Gene_expression of CTLA4 1 53 0.77 29.13 12.07
128 INT69158 Localization of IL4 2 48 0.71 31.3 11.98
129 INT69029 Gene_expression of PTPRC 1 127 0.75 74.26 11.57
130 INT96271 Positive_regulation of Gene_expression of Mcpt1 1 30 0.53 21.34 11.06
131 INT94465 Positive_regulation of Gene_expression of Hand1 1 43 0.38 29.76 10.88
132 INT36453 Binding of ABCA1 3 48 0.45 19.9 10.84
133 INT79656 Positive_regulation of NR3C1 1 14 0.68 6.38 10.83
134 INT4240 Positive_regulation of CCL5 1 32 0.58 20.55 10.65
135 INT11936 Positive_regulation of Positive_regulation of Il6 1 34 0.50 26.85 10.59
136 INT93533 Positive_regulation of Tnfsf11 1 53 0.50 36.93 10.53
137 INT78895 Regulation of CCL5 2 30 0.46 20.45 10.18
138 INT17283 Positive_regulation of CSF1 3 37 0.59 24.16 10.01
139 INT140338 Negative_regulation of Gene_expression of Il17a 2 34 0.46 23.82 9.87
140 INT181344 Gene_expression of Ccr6 7 28 0.61 24.34 9.78
141 INT80549 Binding of ICAM1 2 53 0.47 42.76 9.72
142 INT181405 Gene_expression of Ccl20 1 26 0.65 23.02 9.46
143 INT87495 Positive_regulation of Gene_expression of CCL5 4 26 0.69 13.85 9.46
144 INT28312 Gene_expression of ABCA1 3 85 0.72 37.69 9.27
145 INT226463 Positive_regulation of IL23A 2 23 0.45 21.58 9.18
146 INT155944 Gene_expression of Foxp3 1 66 0.66 24.37 9.12
147 INT48233 Negative_regulation of Gene_expression of MMP1 1 34 0.58 12.94 9.08
148 INT169015 Gene_expression of FOXP3 2 50 0.60 33.18 8.4
149 INT132278 Binding of CTLA4 3 32 0.39 18.69 8.17
150 INT32579 Binding of C4B 2 14 0.36 14.99 7.79
151 INT573 Negative_regulation of C3 1 60 0.59 41.37 7.78
152 INT177759 Negative_regulation of IFN1@ 1 51 0.57 31.81 7.76
153 INT24978 Binding of SFTPA1 1 22 0.47 15.09 7.76
154 INT46221 Positive_regulation of Gene_expression of IgG 1 46 0.53 33.66 7.7
155 INT224648 Gene_expression of Il21 1 15 0.39 18.71 7.47
156 INT91667 Localization of IL12A 1 39 0.74 25.51 7.36
157 INT115213 Regulation of SFTPA1 1 13 0.32 6.91 7.11
158 INT83531 Gene_expression of KITLG 1 54 0.65 26 7.07
159 INT20922 Positive_regulation of Localization of CRH 2 18 0.67 11.12 6.79
160 INT11150 Positive_regulation of Dlst 2 31 0.51 9.01 6.63
161 INT228469 Negative_regulation of Il17a 3 19 0.54 18.76 6.43
162 INT63374 Regulation of Gene_expression of NGF 1 12 0.45 5.6 6.4
163 INT118516 Positive_regulation of Positive_regulation of F2RL1 1 7 0.49 4.63 6.33
164 INT150023 Positive_regulation of Il23a 1 25 0.38 18.33 6.32
165 INT61417 Gene_expression of ITGAL 1 36 0.75 29.62 6.15
166 INT75832 Positive_regulation of Positive_regulation of IL8 1 30 0.70 20.77 6.05
167 INT254269 Gene_expression of Il17f 5 12 0.48 13.29 6.02
168 INT115947 Regulation of Il17a 1 17 0.37 14.26 5.97
169 INT63177 Regulation of HP 1 71 0.44 39.48 5.86
170 INT57502 Positive_regulation of Gene_expression of CRH 1 30 0.70 23.37 5.7
171 INT124705 Binding of Il18 1 29 0.47 19.02 5.59
172 INT87468 Negative_regulation of Mmp2 1 24 0.57 10.79 5.55
173 INT92447 Negative_regulation of Gene_expression of SFTPA1 1 6 0.35 2.81 5.43
174 INT23010 Positive_regulation of CYP19A1 1 28 0.58 24.18 5.37
175 INT173584 Localization of IL17A 1 14 0.74 10.83 5.19
176 INT105393 Positive_regulation of Localization of VEGFA 4 66 0.70 45.45 4.9
177 INT131152 Gene_expression of Cr1l 3 17 0.75 10.83 4.88
178 INT36030 Gene_expression of Il1r1 2 16 0.68 11.42 4.87
179 INT94433 Negative_regulation of TIMP2 1 16 0.55 9.38 4.78
180 INT2725 Positive_regulation of FCER2 4 23 0.69 23.08 4.7
181 INT33466 Negative_regulation of C4B 1 14 0.43 9.06 4.64
182 INT98251 Binding of IL12A 1 20 0.37 16.03 4.51
183 INT7083 Positive_regulation of HBM 1 35 0.66 20.96 4.3
184 INT72747 Localization of IgG 1 55 0.53 30.88 4.19
185 INT156097 Negative_regulation of Localization of VEGFA 1 70 0.58 34.96 4.17
186 INT202417 Gene_expression of Gata3 2 16 0.61 7.84 4.12
187 INT151736 Binding of Hand1 1 15 0.26 9.77 4.04
188 INT235510 Binding of Il17a 1 14 0.34 10.67 3.99
189 INT43931 Binding of CFH 1 49 0.48 31.85 3.96
190 INT9223 Localization of Ighg1 2 22 0.78 11.03 3.67
191 INT81231 Gene_expression of LGALS3 2 26 0.74 9.38 3.66
192 INT46621 Positive_regulation of Gene_expression of CSF1 1 17 0.47 10.53 3.59
193 INT69155 Positive_regulation of Localization of IL4 1 13 0.40 10.18 3.56
194 INT18670 Negative_regulation of ABCA1 1 16 0.54 5.8 3.39
195 INT135408 Transcription of Il17a 2 8 0.64 10.7 3.39
196 INT10594 Gene_expression of Dlst 2 33 0.57 6 3.38
197 INT16236 Negative_regulation of CFH 2 31 0.57 19.59 3.36
198 INT57252 Negative_regulation of PGR 1 22 0.43 12.95 3.33
199 INT174807 Gene_expression of IL26 1 7 0.37 8.06 3.26
200 INT78297 Gene_expression of CD59 3 31 0.72 24.11 3.18
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