J:Shock

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This page displays the top molecular interactions and top single events that were mentioned in the literature in this journal. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported in this journal. They are ordered first by their pain relevance and then by number of times they were reported in this journal. Text mining (TM) confidence, disease relevance and pain relevance are highlighted in green if they are judged to be high and red if not. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Reported in Journal Documents TM Confidence Disease Relevance Pain Relevance
1 INT78590 Nos2 Positive_regulation of PTGS1 2 1 0.00 0.85 0.5
2 INT91686 Mb Positive_regulation of Edn1 1 1 0.03 0.29 0.22
3 INT86951 Ads3 Positive_regulation of Gene_expression of Il10 1 1 0.00 0.42 0.16
4 INT99241 IFNG Regulation of IL1B 2 1 0.21 1.26 0.14
5 INT145830 Mdp1 Positive_regulation of Nod2 1 1 0.34 0.52 0.13
6 INT99242 IFNG Regulation of IL8 1 1 0.23 0.57 0.1
7 INT99243 IFNG Regulation of HLA-DRA 1 1 0.25 0.57 0.1

Single Events

The table below shows the top 100 pain related interactions that have been reported in this journal. They are ordered first by their pain relevance and then by number of times they were reported in this journal. Text mining (TM) confidence, disease relevance and pain relevance are highlighted in green if they are judged to be high and red if not. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Reported in Journal Documents TM Confidence Disease Relevance Pain Relevance
1 INT6483 Gene_expression of TNF 5 3152 0.78 2515.62 929.82
2 INT443 Localization of POMC 2 1020 0.81 284.52 443.17
3 INT720 Positive_regulation of POMC 2 807 0.70 237.37 353.83
4 INT5235 Negative_regulation of TNF 1 924 0.59 772.91 331.98
5 INT5059 Positive_regulation of TNF 6 1050 0.70 896.51 322.81
6 INT9158 Gene_expression of Tnf 13 722 0.78 522.01 277.68
7 INT6852 Localization of TNF 2 883 0.81 705.95 270.84
8 INT9659 Gene_expression of Il6 5 991 0.78 715.11 265.57
9 INT6482 Positive_regulation of Gene_expression of TNF 4 659 0.70 569.88 210
10 INT6488 Gene_expression of Tnf 7 484 0.78 339.61 191.58
11 INT94952 Positive_regulation of Mapk14 1 305 0.70 197.83 186.61
12 INT10194 Positive_regulation of IL6 1 702 0.70 600.62 183.38
13 INT15516 Gene_expression of Crp 3 711 0.77 615.33 173.09
14 INT15515 Positive_regulation of Crp 3 700 0.70 604.24 150.15
15 INT13353 Positive_regulation of Tnf 6 332 0.70 248.75 148.1
16 INT5116 Gene_expression of IL2 3 670 0.78 291.13 146.69
17 INT9660 Regulation of TNF 1 363 0.62 312.94 139.99
18 INT48895 Gene_expression of Il10 7 333 0.78 221.2 138.52
19 INT65600 Positive_regulation of Casp3 2 376 0.70 198.44 128.03
20 INT9235 Negative_regulation of Gene_expression of TNF 4 346 0.59 252.98 118.61
21 INT62124 Gene_expression of NOS1 1 444 0.78 218.08 114.85
22 INT11381 Positive_regulation of IL1B 1 330 0.70 209.31 100.9
23 INT10166 Localization of Tnf 2 237 0.81 153.95 88.64
24 INT10534 Positive_regulation of Trib3 1 209 0.60 78.75 81.48
25 INT99070 Gene_expression of Mapk14 1 147 0.78 103.99 79.59
26 INT2431 Positive_regulation of Mpo 2 275 0.70 211.99 78.47
27 INT15769 Gene_expression of Il1b 1 146 0.78 114.51 75.35
28 INT48244 Gene_expression of Il4 4 172 0.76 132.38 73.42
29 INT9236 Regulation of Gene_expression of TNF 1 204 0.62 162.66 72.99
30 INT58400 Negative_regulation of Tnf 2 182 0.59 129.97 71
31 INT49995 Positive_regulation of Gene_expression of Tnf 1 187 0.70 125.07 70.54
32 INT6849 Localization of IL1B 1 229 0.81 112.56 69.63
33 INT6176 Positive_regulation of Htr1a 2 117 0.67 28.23 66.17
34 INT11937 Localization of Il6 1 228 0.81 139.83 64.39
35 INT1951 Positive_regulation of Tlr4 1 345 0.70 176.99 62.42
36 INT1169 Negative_regulation of Bche 1 322 0.59 149.22 61.27
37 INT9196 Gene_expression of PTGS1 1 215 0.77 96.99 60.5
38 INT7340 Regulation of Grin1 1 87 0.62 30.37 57.93
39 INT48891 Positive_regulation of Il10 3 143 0.70 101.42 56.72
40 INT1200 Negative_regulation of Ins1 1 274 0.58 155.17 56.14
41 INT69876 Negative_regulation of Nfkb1 1 147 0.58 89.81 55.5
42 INT52800 Negative_regulation of Gene_expression of Tnf 3 142 0.59 92.27 55.47
43 INT1456 Regulation of Oprl1 1 61 0.62 19.5 52.87
44 INT929 Positive_regulation of Oprl1 2 64 0.70 14.67 52.84
45 INT62543 Gene_expression of Icam1 7 231 0.78 187.58 52.71
46 INT49017 Negative_regulation of Gene_expression of Nos2 2 169 0.59 80.64 52.67
47 INT22112 Positive_regulation of Localization of TNF 2 164 0.70 115.66 52.18
48 INT2323 Gene_expression of Trh 1 146 0.78 29.92 49.5
49 INT374 Positive_regulation of Ldha 1 212 0.70 107.08 47.43
50 INT55670 Negative_regulation of Gene_expression of Tnf 1 83 0.59 57.16 46.33
51 INT5781 Gene_expression of Edn1 1 190 0.78 99.1 46
52 INT5307 Regulation of Tnf 1 87 0.62 78.71 43.4
53 INT11939 Negative_regulation of Il6 1 138 0.59 87.46 41.24
54 INT18992 Negative_regulation of Pdpk1 1 53 0.42 19.02 40.95
55 INT1596 Negative_regulation of Oprl1 2 61 0.57 13.5 38.41
56 INT64558 Negative_regulation of Nos1 1 88 0.58 26.76 36.78
57 INT84260 Positive_regulation of Mapk8 2 124 0.69 72.84 35.98
58 INT48896 Positive_regulation of Gene_expression of Il10 2 73 0.70 43.14 35.5
59 INT16960 Gene_expression of Crp 1 166 0.76 116.21 34.07
60 INT95734 Phosphorylation of Mapk8 3 108 0.82 49.92 33.52
61 INT65536 Negative_regulation of Positive_regulation of Nfkb1 4 77 0.59 38.86 33.33
62 INT7133 Negative_regulation of MME 1 85 0.59 29.22 33.1
63 INT81530 Gene_expression of Nfkb1 5 93 0.78 48.58 32.58
64 INT35406 Localization of Tnf 1 94 0.81 64.63 31.65
65 INT9993 Positive_regulation of Gene_expression of IL2 2 131 0.69 46.27 30.04
66 INT10915 Gene_expression of ITGAM 2 164 0.78 92.42 29.78
67 INT12751 Gene_expression of Pigm 5 91 0.58 22.42 29.2
68 INT651 Positive_regulation of PTGS1 1 93 0.69 37.27 29.18
69 INT16428 Positive_regulation of Gtf3a 1 135 0.20 106.44 26.67
70 INT52801 Regulation of Gene_expression of Tnf 1 55 0.62 48.74 26.59
71 INT5650 Gene_expression of Mpo 2 117 0.77 80.27 26.42
72 INT1761 Positive_regulation of PTGER2 1 135 0.49 90.17 26.26
73 INT66025 Gene_expression of Itgam 7 61 0.78 31.26 26.08
74 INT76095 Positive_regulation of ISYNA1 1 117 0.55 79.73 25.86
75 INT6115 Positive_regulation of Pigm 3 82 0.64 16.96 25.73
76 INT61953 Transcription of Nos2 1 101 0.72 46.64 25.49
77 INT73670 Gene_expression of Vcam1 5 128 0.78 123.79 24.96
78 INT57874 Gene_expression of Egr1 6 113 0.78 68.46 24.95
79 INT49141 Gene_expression of Selp 5 157 0.78 85.22 24.78
80 INT48766 Regulation of NOS1 1 73 0.61 37.01 24.59
81 INT6726 Positive_regulation of Edn1 2 118 0.70 65.96 24.07
82 INT99069 Positive_regulation of Gene_expression of Mapk14 1 42 0.53 29.84 23.16
83 INT48081 Localization of Il1b 1 46 0.80 21.59 22.4
84 INT5905 Negative_regulation of ELANE 1 113 0.59 47.43 22.09
85 INT99068 Gene_expression of Mapk8 1 62 0.78 33.57 21.25
86 INT69304 Negative_regulation of Il10 2 47 0.59 36.88 19.79
87 INT6993 Negative_regulation of Mpo 1 72 0.59 61.83 19.51
88 INT66755 Transcription of Tnf 4 45 0.72 37.1 19.11
89 INT7000 Positive_regulation of Htr2a 2 42 0.67 9.48 18.7
90 INT11938 Positive_regulation of Localization of Il6 1 61 0.70 35.72 18.25
91 INT61257 Gene_expression of Sele 5 79 0.77 70.97 17.78
92 INT104493 Negative_regulation of Mapk8 1 56 0.53 27.76 16.86
93 INT10169 Positive_regulation of Localization of Tnf 1 44 0.70 27.71 16.75
94 INT61949 Regulation of Nos2 1 74 0.58 34.08 16.7
95 INT66023 Positive_regulation of Gene_expression of Itgam 2 25 0.64 12.65 16.56
96 INT19929 Negative_regulation of Positive_regulation of TNF 1 52 0.59 38.16 16.51
97 INT10918 Gene_expression of ITGB2 2 93 0.76 71.8 16.34
98 INT20622 Gene_expression of LDHA 1 107 0.76 77.97 16.3
99 INT43906 Regulation of Tlr4 1 71 0.53 35.18 15.49
100 INT79227 Negative_regulation of Gene_expression of Icam1 1 45 0.59 41.65 14.97
101 INT109535 Gene_expression of Vegfa 5 116 0.75 84.61 14.89
102 INT69303 Positive_regulation of Gene_expression of Il4 1 27 0.68 20.01 14.8
103 INT57878 Positive_regulation of Gene_expression of Egr1 3 36 0.70 20.42 14.45
104 INT25266 Positive_regulation of Localization of IL1B 1 38 0.69 15.89 14.35
105 INT36262 Positive_regulation of Tbce 2 35 0.49 28.79 14.33
106 INT35120 Gene_expression of Sdcbp 1 68 0.67 21.33 13.96
107 INT95738 Positive_regulation of Phosphorylation of Mapk8 1 40 0.70 23.46 13.88
108 INT7997 Gene_expression of Ltc4s 1 51 0.76 34.28 13.8
109 INT94051 Positive_regulation of Arg1 3 41 0.60 36.22 13.72
110 INT99780 Positive_regulation of Cxcl10 1 43 0.69 39.67 13.27
111 INT101147 Gene_expression of Uchl1 4 31 0.76 14.73 13.22
112 INT2385 Gene_expression of MIF 1 57 0.68 40.74 12.78
113 INT86950 Negative_regulation of Gene_expression of Il10 3 26 0.42 18.92 12.73
114 INT58226 Negative_regulation of Gene_expression of Il1b 1 24 0.57 18.09 12.68
115 INT32203 Negative_regulation of Crp 1 48 0.58 32.77 11.89
116 INT13303 Positive_regulation of PTAFR 2 40 0.69 16.27 11.56
117 INT14204 Protein_catabolism of KNG1 1 41 0.96 20.94 11.47
118 INT60500 Negative_regulation of Tbce 1 21 0.41 13.3 11.1
119 INT81531 Positive_regulation of Gene_expression of Nfkb1 2 27 0.69 13.9 11.04
120 INT8801 Gene_expression of Csf3 1 71 0.74 45.6 10.83
121 INT475 Negative_regulation of Adra1a 1 28 0.58 7.87 9.83
122 INT11859 Positive_regulation of Tbxa2r 1 44 0.61 22.62 9.61
123 INT57876 Positive_regulation of Egr1 1 46 0.70 25.6 9.41
124 INT3703 Negative_regulation of Grhpr 2 38 0.50 11.43 9.2
125 INT12991 Negative_regulation of Gene_expression of PTGS1 1 28 0.41 13.39 8.9
126 INT108098 Positive_regulation of Itgam 1 19 0.70 8.09 8.86
127 INT104481 Regulation of Mapk8 1 21 0.50 13.87 8.41
128 INT24141 Negative_regulation of Apcs 2 24 0.59 16.82 8.29
129 INT63401 Gene_expression of Il5 2 33 0.72 18.66 8.2
130 INT30526 Negative_regulation of PTAFR 1 15 0.58 8.15 8.19
131 INT48077 Positive_regulation of Localization of Il1b 1 17 0.69 8.8 7.68
132 INT102351 Regulation of Pecam1 1 7 0.61 22.45 7.58
133 INT1952 Negative_regulation of Positive_regulation of Tlr4 1 33 0.51 15.8 7.41
134 INT11858 Localization of Tbxa2r 1 39 0.80 21.24 7.09
135 INT10505 Gene_expression of Ptafr 1 18 0.62 10.7 6.83
136 INT64792 Positive_regulation of Gene_expression of ITGAM 2 39 0.69 23.21 6.71
137 INT60700 Gene_expression of Itgax 1 93 0.71 51.89 6.57
138 INT65538 Regulation of Positive_regulation of Nfkb1 1 17 0.51 8.31 6.5
139 INT93658 Transcription of Nos1 1 16 0.72 6.85 6.16
140 INT94055 Gene_expression of Arg1 4 22 0.68 20.81 6.13
141 INT91657 Negative_regulation of IL18 1 20 0.48 15.97 6.12
142 INT58484 Regulation of Il4 2 12 0.45 8.67 6.09
143 INT121370 Positive_regulation of MIF 1 22 0.70 17.79 6.08
144 INT37745 Positive_regulation of Gene_expression of Sdcbp 1 22 0.60 5.15 6.02
145 INT32532 Regulation of Positive_regulation of Pomc 1 11 0.61 3.2 5.93
146 INT69929 Gene_expression of S100a9 2 11 0.77 16.12 5.79
147 INT53684 Negative_regulation of Gene_expression of ITGAM 2 23 0.59 14.36 5.66
148 INT58145 Positive_regulation of Localization of Tnf 1 20 0.67 13.33 5.44
149 INT11062 Positive_regulation of MME 5 24 0.63 14.37 5.26
150 INT67228 Regulation of Gene_expression of Il4 1 11 0.50 6.67 5.2
151 INT1285 Localization of Mmp13 1 12 0.78 8.98 4.93
152 INT10605 Positive_regulation of Ltc4s 1 21 0.68 17.22 4.8
153 INT17103 Negative_regulation of Prep 1 15 0.38 4.95 4.71
154 INT88059 Positive_regulation of Ptger4 1 9 0.69 1.41 4.4
155 INT66024 Negative_regulation of Gene_expression of Itgam 2 9 0.59 5.5 4.38
156 INT52133 Regulation of Localization of Il6 1 7 0.61 5.35 4.37
157 INT84700 Positive_regulation of HSP90B2P 1 34 0.67 30.22 4.07
158 INT70326 Positive_regulation of Gene_expression of ITGB2 2 24 0.67 15.42 3.86
159 INT60933 Positive_regulation of Apcs 2 16 0.67 11.69 3.68
160 INT104480 Phosphorylation of Mapk9 3 8 0.80 6.59 3.62
161 INT31580 Negative_regulation of Cyp11a1 1 14 0.57 3.48 3.61
162 INT14558 Regulation of Positive_regulation of Oprl1 1 6 0.43 2.49 3.5
163 INT69216 Positive_regulation of Tgfb1 1 14 0.49 5.84 3.29
164 INT119470 Regulation of Ptger4 3 6 0.43 3.94 3.24
165 INT65427 Regulation of Positive_regulation of Tnf 1 7 0.60 3.49 3.22
166 INT53683 Negative_regulation of Gene_expression of ITGB2 2 10 0.57 9.11 3.2
167 INT97599 Gene_expression of Il20 1 4 0.23 5.11 2.98
168 INT95049 Negative_regulation of Regulation of Tnf 1 4 0.42 1.64 2.84
169 INT33996 Positive_regulation of Negative_regulation of Oprl1 1 4 0.53 1.34 2.68
170 INT93207 Negative_regulation of Cyp4a3 1 11 0.36 4.32 2.63
171 INT95739 Negative_regulation of Phosphorylation of Mapk8 1 11 0.42 6.77 2.61
172 INT120011 Localization of MIF 1 6 0.58 5.72 2.6
173 INT96640 Negative_regulation of Gene_expression of Egr1 3 13 0.43 7.22 2.48
174 INT16964 Binding of IFNG 1 27 0.48 14.31 2.45
175 INT26434 Localization of MME 1 17 0.81 8.67 2.3
176 INT94060 Transcription of ISYNA1 2 18 0.43 6.7 2.18
177 INT124583 Negative_regulation of Elane 5 8 0.29 5.26 2.14
178 INT104494 Phosphorylation of S100a4 3 1 0.24 2.92 2.07
179 INT94050 Negative_regulation of Arg1 2 6 0.39 6.07 2.06
180 INT94056 Positive_regulation of Gene_expression of Arg1 3 8 0.60 6.57 1.95
181 INT51502 Positive_regulation of Elane 1 5 0.22 2.3 1.94
182 INT104489 Positive_regulation of S100a4 3 1 0.20 2.66 1.9
183 INT14914 Regulation of Cdh5 2 5 0.52 4.59 1.85
184 INT83358 Positive_regulation of Elane 1 8 0.21 8.14 1.83
185 INT61939 Negative_regulation of Positive_regulation of Tbce 2 5 0.06 4.82 1.82
186 INT104478 Positive_regulation of Mapk9 2 5 0.67 5.56 1.81
187 INT85302 Negative_regulation of Cyp2b21 3 6 0.20 8.94 1.8
188 INT91374 Negative_regulation of Gene_expression of Nfkb1 1 12 0.58 5.06 1.75
189 INT138660 Positive_regulation of Regulation of Grin1 1 2 0.24 1.59 1.71
190 INT104479 Negative_regulation of Mapk9 1 3 0.37 2.83 1.69
191 INT76416 Positive_regulation of Gene_expression of Il5 1 9 0.08 4.16 1.65
192 INT28714 Negative_regulation of Csf3 1 10 0.41 6.9 1.6
193 INT94054 Regulation of Arg1 1 5 0.47 5.37 1.57
194 INT32625 Positive_regulation of Uchl1 3 2 0.49 1.39 1.4
195 INT128188 Negative_regulation of Cd14 1 4 0.12 2.42 1.36
196 INT141344 Transcription of Egr1 2 11 0.70 5.59 1.34
197 INT90226 Gene_expression of Mapk9 1 3 0.65 1.94 1.34
198 INT104486 Positive_regulation of Taok3 2 1 0.33 1.88 1.28
199 INT104495 Regulation of Positive_regulation of Taok3 2 1 0.21 1.88 1.28
200 INT37006 Regulation of S100a4 2 2 0.13 1.74 1.21
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