J:The European Journal of Neuroscience

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This page displays the top molecular interactions and top single events that were mentioned in the literature in this journal. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported in this journal. They are ordered first by their pain relevance and then by number of times they were reported in this journal. Text mining (TM) confidence, disease relevance and pain relevance are highlighted in green if they are judged to be high and red if not. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Reported in Journal Documents TM Confidence Disease Relevance Pain Relevance
1 INT158770 Binding of Trpv1 and Trpa1 5 3 0.34 2.07 3.5
2 INT151381 St8sia1 Positive_regulation of Cck 1 2 0.19 0.45 2.7
3 INT158809 Pag1 Regulation of Rvm 1 1 0.02 1.28 2.33
4 INT208991 Binding of CALM1 and Ca2 10 1 0.06 1.34 1.55
5 INT151382 St8sia1 Positive_regulation of Cck Regulation of St8sia1 1 1 0.04 0.22 1.35
6 INT150835 Gper Positive_regulation of Localization of Prkce 1 2 0.15 0.62 1.18
7 INT130167 Trpv1 Regulation of Localization of Calca 2 1 0.38 0.69 1.03
8 INT221257 Pde5a Positive_regulation of PRKG1 3 1 0.07 0.19 0.86
9 INT152947 Dlg4 Regulation of Sgk1 1 1 0.09 0.18 0.76
10 INT152945 Dlg4 Regulation of Cap1 1 1 0.11 0.18 0.76
11 INT152949 Homer1 Regulation of Sgk1 1 1 0.28 0.18 0.76
12 INT152946 Homer1 Regulation of Cap1 1 1 0.32 0.18 0.76
13 INT257222 Binding of Ltp and Pde5a 2 1 0.07 0.14 0.75
14 INT152948 Homer1 Regulation of Gpr88 1 1 0.36 0.18 0.75
15 INT152944 Dlg4 Regulation of Gpr88 1 1 0.12 0.18 0.75
16 INT162224 Grin1 Positive_regulation of Gene_expression of Gria1 1 1 0.27 0.07 0.66
17 INT162223 Grin1 Positive_regulation of Localization of Gria2 1 1 0.23 0.07 0.66
18 INT150833 Esr1 Positive_regulation of Localization of Prkce 1 1 0.08 0.29 0.51
19 INT257220 Binding of Nos1 and Flvcr2 1 1 0.00 0.17 0.47
20 INT257229 Binding of PRKG1 and Pde5a 1 1 0.01 0.17 0.41
21 INT325701 Aacs Regulation of Car3 1 1 0.17 0 0.4
22 INT153052 Prkcg Positive_regulation of Phosphorylation of Trpv1 1 1 0.45 0 0.38
23 INT153648 Binding of Accn4 and Ubb 1 1 0.01 0.09 0.35
24 INT153650 Accn4 Positive_regulation of Regulation of ASIC1 1 1 0.12 0.1 0.33
25 INT153651 Accn4 Regulation of ASIC1 1 1 0.08 0.08 0.31
26 INT257223 Ltp Positive_regulation of Gene_expression of Nos1 1 1 0.03 0.07 0.24
27 INT149791 Binding of Lrp8 and Reln 4 1 0.36 0.38 0.22
28 INT257231 PRKG1 Negative_regulation of Ltp 1 1 0.07 0.07 0.2
29 INT257233 PRKG1 Positive_regulation of Phosphorylation of Creb1 1 1 0.01 0.09 0.2
30 INT257224 Pde5a Positive_regulation of Phosphorylation of Creb1 1 1 0.03 0.09 0.2
31 INT257218 Camk1 Negative_regulation of Nos1 1 1 0.04 0.09 0.19
32 INT257232 Negative_regulation of Binding of GRIN1 and Camk2a 1 1 0.13 0 0.19
33 INT257234 Binding of GRIN1 and Camk2a 1 1 0.12 0 0.19
34 INT287014 Gabrd Regulation of Ptn 1 1 0.10 0 0.18
35 INT149797 RGD1565648 Positive_regulation of Trpa1 1 1 0.00 0.18 0.17
36 INT149798 Atp7b Positive_regulation of Trpa1 1 1 0.23 0.18 0.17
37 INT257230 Binding of CALM1 and Nos1 1 1 0.00 0 0.15
38 INT149792 Binding of Reln and Vldlr 3 2 0.51 0.35 0.11
39 INT257217 Binding of Pde2a and Pde5a 1 1 0.03 0 0.1
40 INT257221 Negative_regulation of Binding of Src and Pde5a 1 1 0.03 0 0.08
41 INT257219 Binding of Src and Pde5a 1 1 0.02 0 0.08
42 INT257226 Phosphorylation of Prkacb Positive_regulation of Npr1 1 1 0.00 0 0.08
43 INT257227 Pik3cd Positive_regulation of Akt1 1 1 0.01 0.33 0.05
44 INT337608 Pde5a Regulation of Cnga1 1 1 0.00 0 0.04
45 INT149794 Binding of LRP8 and Vldlr 1 1 0.02 0.17 0.04
46 INT149793 Binding of LRP8 and Reln 1 1 0.03 0.17 0.04
47 INT160810 Gria2 Regulation of Shisa9 1 1 0.00 0 0

Single Events

The table below shows the top 100 pain related interactions that have been reported in this journal. They are ordered first by their pain relevance and then by number of times they were reported in this journal. Text mining (TM) confidence, disease relevance and pain relevance are highlighted in green if they are judged to be high and red if not. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Reported in Journal Documents TM Confidence Disease Relevance Pain Relevance
1 INT796 Gene_expression of Penk 38 1902 0.78 275.47 1057.59
2 INT7114 Positive_regulation of Ltp 1 1192 0.62 290.76 755.77
3 INT1912 Gene_expression of Calca 24 1152 0.78 453.25 739.84
4 INT58061 Gene_expression of Trpv1 35 1117 0.78 451.54 637.59
5 INT728 Positive_regulation of Penk 18 1068 0.70 186.9 636.87
6 INT5228 Positive_regulation of Fos 22 934 0.70 209.8 503.87
7 INT5895 Gene_expression of Oprm1 25 525 0.78 120.67 407.29
8 INT64202 Positive_regulation of Trpv1 17 643 0.70 249.66 397.42
9 INT6580 Negative_regulation of Ptgs1 2 929 0.59 381.53 376.26
10 INT2649 Regulation of Calca 5 433 0.62 146.05 330.95
11 INT5540 Positive_regulation of Oprm1 7 344 0.70 76.77 319.71
12 INT5680 Gene_expression of Ngf 12 530 0.78 264.29 310.56
13 INT9131 Positive_regulation of Prkcg 14 431 0.70 130.8 302.41
14 INT11377 Positive_regulation of Ngf 18 331 0.70 206.5 238
15 INT1665 Positive_regulation of Pag1 7 270 0.68 186.63 229.87
16 INT6406 Binding of Oprm1 1 280 0.48 40.54 226.26
17 INT6293 Gene_expression of Oprm1 1 312 0.78 48.73 215.61
18 INT4893 Gene_expression of Tacr1 15 366 0.78 129.67 213.92
19 INT4893 Gene_expression of Tacr1 7 366 0.78 129.67 213.92
20 INT9132 Negative_regulation of Prkcg 7 279 0.59 88.05 203.47
21 INT798 Positive_regulation of Gene_expression of Penk 11 394 0.70 78.53 203.07
22 INT2211 Negative_regulation of Abat 2 267 0.59 66.51 200.98
23 INT6354 Localization of Gabrg1 12 321 0.74 41.41 186.74
24 INT6354 Localization of Gabrg1 22 321 0.74 41.41 186.74
25 INT12602 Negative_regulation of Oprm1 5 190 0.59 36.11 177.85
26 INT66280 Gene_expression of Nos2 2 534 0.78 330.78 157.07
27 INT120811 Gene_expression of Gopc 1 1174 0.59 428.49 150.55
28 INT7628 Gene_expression of Ltp 1 273 0.77 70.21 147.87
29 INT1033 Positive_regulation of Ca2 9 507 0.68 131.76 147.64
30 INT14843 Gene_expression of Gabrg1 3 301 0.77 62.63 139.16
31 INT2541 Binding of Calca 1 200 0.48 67.14 134.62
32 INT60126 Regulation of Trpv1 7 186 0.62 85.53 133.4
33 INT11012 Positive_regulation of Creb1 3 258 0.70 84.4 132
34 INT115386 Gene_expression of Ppara 1 779 0.77 549.99 128.36
35 INT6822 Gene_expression of Pdyn 3 215 0.78 35.99 125.76
36 INT5008 Localization of Calca 13 204 0.81 80.35 125.16
37 INT6323 Positive_regulation of Gabrg1 3 213 0.70 45.08 124.34
38 INT85640 Gene_expression of Tg(CAG-EGFP)D4Nagy 4 1138 0.72 311.58 119.18
39 INT85640 Gene_expression of Tg(CAG-EGFP)D4Nagy 4 1138 0.72 311.58 119.18
40 INT5010 Gene_expression of Calca 4 197 0.78 85.76 118.75
41 INT92669 Gene_expression of Bdnf 6 309 0.78 178.26 116.68
42 INT170025 Gene_expression of Fig4 4 588 0.67 183.27 113.32
43 INT49651 Gene_expression of Creb1 6 276 0.78 114.77 111.96
44 INT65731 Gene_expression of Cnr1 24 234 0.78 63.82 109.34
45 INT49171 Gene_expression of Nos1 3 241 0.78 140.7 104.76
46 INT4742 Gene_expression of Tac1 2 177 0.78 69.99 102.66
47 INT74826 Gene_expression of Slc1a2 2 131 0.78 61.83 100.84
48 INT97701 Phosphorylation of Mapk14 9 191 0.82 115.33 100.46
49 INT7944 Positive_regulation of Fos 3 193 0.70 60.69 98.31
50 INT4822 Localization of Ca2 6 417 0.80 99.57 96.45
51 INT18755 Positive_regulation of Rvm 5 79 0.60 60 92.93
52 INT69764 Positive_regulation of Cnr1 7 126 0.70 67.8 91.49
53 INT69764 Positive_regulation of Cnr1 1 126 0.70 67.8 91.49
54 INT9516 Negative_regulation of Gabrg1 3 149 0.53 27.83 91.02
55 INT9516 Negative_regulation of Gabrg1 3 149 0.53 27.83 91.02
56 INT38731 Localization of Trpv1 1 138 0.81 52.73 90.49
57 INT6585 Positive_regulation of Insrr 6 110 0.52 40.67 89.9
58 INT74376 Gene_expression of Cnr1 3 173 0.78 73.43 89.7
59 INT12763 Phosphorylation of Prkcg 5 167 0.82 38.91 89.63
60 INT1635 Gene_expression of Vip 2 245 0.78 53.36 88.13
61 INT4830 Binding of Trpv1 7 158 0.48 45.11 84.2
62 INT4830 Binding of Trpv1 2 158 0.48 45.11 84.2
63 INT2520 Negative_regulation of Ca2 2 271 0.57 72.13 83.71
64 INT16254 Positive_regulation of Gene_expression of Ngf 10 144 0.70 80.61 82.08
65 INT99070 Gene_expression of Mapk14 4 147 0.78 103.99 79.59
66 INT123584 Gene_expression of Trpa1 3 176 0.78 83 78.65
67 INT29708 Gene_expression of Gria1 1 177 0.78 56.36 77.37
68 INT24958 Gene_expression of Nkx1-1 4 106 0.74 51.29 76.88
69 INT25363 Negative_regulation of Trpv1 2 144 0.59 64.78 75.7
70 INT98621 Regulation of Trpv1 2 121 0.62 79.24 75.23
71 INT117601 Positive_regulation of Trpa1 6 174 0.70 72.41 71.9
72 INT57380 Phosphorylation of Creb1 1 213 0.82 66.8 71.26
73 INT5852 Gene_expression of Penk 3 167 0.78 44.44 71.13
74 INT171145 Positive_regulation of Fig4 6 274 0.59 93.55 69.81
75 INT13276 Regulation of Ltp 1 107 0.53 30.78 69.13
76 INT39777 Regulation of Prkcg 1 90 0.62 31.52 68.17
77 INT13286 Gene_expression of Ca2 4 317 0.67 71.58 65.01
78 INT96622 Localization of Trpv1 5 110 0.81 59.82 63.25
79 INT2761 Regulation of Gabrg1 3 119 0.61 18.8 60.52
80 INT103924 Positive_regulation of Akt1 1 359 0.69 158.94 60.34
81 INT109431 Gene_expression of Trpa1 2 123 0.78 51.84 59.98
82 INT109431 Gene_expression of Trpa1 19 123 0.78 51.84 59.98
83 INT102020 Gene_expression of Creb1 3 190 0.78 57.31 59.77
84 INT79093 Positive_regulation of Nos1 5 101 0.70 46.89 59.61
85 INT7032 Positive_regulation of Pdyn 3 94 0.66 26.51 58.83
86 INT13938 Positive_regulation of Nkx1-1 7 64 0.68 30.83 58.75
87 INT82055 Positive_regulation of Creb1 2 176 0.70 60.2 58.39
88 INT82055 Positive_regulation of Creb1 1 176 0.70 60.2 58.39
89 INT5017 Negative_regulation of Tacr1 1 76 0.58 17 57.07
90 INT74389 Gene_expression of Gdnf 13 131 0.78 58.52 57.06
91 INT647 Gene_expression of SGCG 2 211 0.75 78.46 55.82
92 INT49436 Binding of TRPV1 1 145 0.48 38.35 55.08
93 INT8071 Positive_regulation of Gria1 4 102 0.70 26.61 53.37
94 INT1032 Regulation of Ca2 1 202 0.52 54.91 53.03
95 INT97674 Positive_regulation of Localization of Calca 6 70 0.69 27.71 51.79
96 INT76620 Gene_expression of Cnr2 13 93 0.78 34.7 50.14
97 INT109430 Positive_regulation of Trpa1 4 119 0.70 44 49.14
98 INT109430 Positive_regulation of Trpa1 3 119 0.70 44 49.14
99 INT4345 Gene_expression of Gtf3a 3 157 0.67 80.75 48.47
100 INT12471 Regulation of Insrr 2 52 0.35 17.8 48.31
101 INT16850 Negative_regulation of Localization of Gabrg1 2 73 0.51 8.28 47.89
102 INT16850 Negative_regulation of Localization of Gabrg1 9 73 0.51 8.28 47.89
103 INT106525 Phosphorylation of Akt1 2 436 0.82 183.81 47.82
104 INT29144 Gene_expression of Rvm 1 41 0.52 29.23 47.76
105 INT170646 Negative_regulation of Fig4 5 213 0.37 81.29 46.92
106 INT14853 Negative_regulation of Tac1 3 80 0.59 30.87 45.06
107 INT88617 Positive_regulation of Gene_expression of Creb1 3 90 0.69 51.69 44.29
108 INT8824 Regulation of Vip 1 95 0.62 15.7 43.63
109 INT66383 Phosphorylation of Prkaca 2 143 0.80 30.85 43.38
110 INT26788 Gene_expression of Gad1 15 93 0.78 27.05 42.71
111 INT9298 Positive_regulation of Gtpbp4 4 64 0.69 12.29 41.97
112 INT60388 Gene_expression of Helt 1 90 0.07 19.18 41.72
113 INT65245 Gene_expression of Nos3 2 121 0.78 98.14 41.56
114 INT28265 Positive_regulation of Calca 3 62 0.70 29.1 41.17
115 INT7824 Regulation of Cck 1 39 0.62 5.31 39.28
116 INT6357 Positive_regulation of Localization of Gabrg1 3 53 0.41 7.03 39.21
117 INT173693 Localization of Gopc 1 249 0.65 70.49 38.81
118 INT16455 Gene_expression of Drd2 1 116 0.78 22.71 38.47
119 INT4925 Binding of Tacr1 2 57 0.48 17.39 38.38
120 INT30817 Gene_expression of Th 5 142 0.76 33.56 38.12
121 INT115649 Gene_expression of Camk2a 1 95 0.78 33.22 38
122 INT88081 Negative_regulation of Gene_expression of Oprm1 7 45 0.59 16.56 37.5
123 INT97702 Positive_regulation of Phosphorylation of Mapk14 6 69 0.69 49.21 36.81
124 INT64436 Gene_expression of P2rx1 2 93 0.78 32.69 36.12
125 INT14137 Localization of Oprm1 3 56 0.81 2.88 36.09
126 INT8837 Positive_regulation of TAC1 1 59 0.67 21.94 35.97
127 INT66005 Regulation of Cnr1 5 47 0.61 19.21 34.52
128 INT129686 Gene_expression of FSCN1 2 46 0.15 18.91 34.47
129 INT47710 Negative_regulation of GRIN1 1 71 0.57 25.57 34.24
130 INT7833 Positive_regulation of Cck 3 33 0.70 8.54 34.21
131 INT16714 Regulation of Creb1 1 64 0.62 22.23 33.56
132 INT50308 Binding of Cnr1 2 61 0.48 14.41 33.52
133 INT114729 Phosphorylation of Camk2a 1 110 0.82 15.49 33.19
134 INT9796 Gene_expression of Cck 3 63 0.78 11.44 32.09
135 INT9796 Gene_expression of Cck 2 63 0.78 11.44 32.09
136 INT10453 Positive_regulation of Gad1 12 65 0.70 10.75 31.9
137 INT49001 Regulation of Gria1 1 51 0.56 18.28 31.22
138 INT8027 Regulation of Gene_expression of Ngf 2 34 0.62 26.32 31.16
139 INT106554 Positive_regulation of Gene_expression of Bdnf 1 73 0.70 42.58 30.77
140 INT70776 Positive_regulation of P2rx1 1 62 0.62 32.55 30.75
141 INT11279 Positive_regulation of Penk 4 65 0.70 18.72 30.29
142 INT16769 Positive_regulation of Positive_regulation of Oprm1 2 31 0.57 8.29 29.66
143 INT72252 Gene_expression of Kcnma1 2 63 0.64 20.47 29.56
144 INT66868 Positive_regulation of Ceacam3 5 40 0.69 26.61 28.9
145 INT1616 Regulation of Gad1 3 46 0.61 10.2 28.64
146 INT56525 Gene_expression of Gria2 1 74 0.75 23.15 28.6
147 INT154007 Gene_expression of da 2 46 0.56 15.28 28.22
148 INT66381 Regulation of Prkaca 1 40 0.62 13.38 27.96
149 INT177581 Regulation of Fig4 1 113 0.41 39.26 27.75
150 INT111359 Localization of Cnr1 6 55 0.81 11.25 27.41
151 INT51602 Gene_expression of Grm5 1 59 0.75 17.29 26.99
152 INT20585 Gene_expression of Gfra1 3 39 0.77 26.94 26.69
153 INT76621 Positive_regulation of Cnr2 1 32 0.69 17.77 26.57
154 INT93360 Gene_expression of Slc6a3 2 63 0.78 19.54 26.55
155 INT13995 Gene_expression of gr 4 96 0.74 48.21 26.54
156 INT7832 Localization of Cck 1 39 0.81 6.81 26.54
157 INT56524 Gene_expression of Grip2 2 67 0.74 14.77 26.23
158 INT48832 Positive_regulation of Grip2 1 48 0.69 12.13 25.99
159 INT80791 Gene_expression of Slc6a3 1 113 0.78 11.89 25.76
160 INT8779 Binding of TAC1 1 50 0.47 11.19 25.57
161 INT77793 Positive_regulation of Gdnf 6 54 0.70 23.76 25.08
162 INT5851 Positive_regulation of Gene_expression of Penk 4 52 0.70 14.57 25.05
163 INT19986 Negative_regulation of Cck 1 31 0.59 4.32 24.99
164 INT57192 Binding of Ltp 1 43 0.41 17.48 24.96
165 INT30276 Positive_regulation of Gene_expression of Pdyn 2 39 0.67 11.28 24.89
166 INT74377 Regulation of Cnr1 1 38 0.59 16.93 24.77
167 INT20003 Gene_expression of Scn2a1 2 125 0.71 8.78 23.94
168 INT101225 Positive_regulation of Gria2 5 62 0.64 28.1 23.93
169 INT7827 Binding of Cck 3 32 0.48 4.66 23.73
170 INT49172 Regulation of Nos1 3 43 0.52 27.53 23.66
171 INT9282 Gene_expression of HTR1B 1 48 0.75 12.15 22.94
172 INT76249 Gene_expression of Gria1 1 67 0.75 15.07 22.78
173 INT51801 Gene_expression of Gabrd 2 64 0.72 19.17 22.61
174 INT78571 Positive_regulation of Grm5 1 35 0.69 11.81 22.45
175 INT127435 Gene_expression of Per1 2 89 0.77 13.94 22.31
176 INT7715 Regulation of Drd2 2 35 0.62 10.79 22.3
177 INT16851 Regulation of Localization of Gabrg1 4 34 0.39 4.34 22.29
178 INT89056 Phosphorylation of Trpv1 5 46 0.82 13.52 22.16
179 INT10536 Gene_expression of Trib3 3 67 0.66 27.08 21.58
180 INT129987 Phosphorylation of Gria1 4 63 0.80 20.65 21.02
181 INT153613 Gene_expression of Napepld 1 42 0.77 6.7 20.94
182 INT93485 Negative_regulation of Slc1a2 2 27 0.59 10.65 20.9
183 INT171820 Localization of Fig4 2 144 0.65 27.38 20.88
184 INT56769 Gene_expression of Ntrk1 3 36 0.77 15.79 20.75
185 INT61159 Regulation of Gene_expression of Creb1 1 46 0.62 24.07 20.52
186 INT16326 Transcription of Gad1 10 58 0.71 15.78 20.45
187 INT24240 Positive_regulation of Th 3 60 0.70 9.92 20.18
188 INT111401 Positive_regulation of Gene_expression of Tg(CAG-EGFP)D4Nagy 4 134 0.61 34.87 20.15
189 INT81210 Positive_regulation of PRKG1 8 71 0.70 26.83 19.89
190 INT104527 Binding of FSCN1 3 18 0.23 14.75 19.6
191 INT33327 Positive_regulation of Gene_expression of Gabrg1 2 39 0.69 9.68 18.82
192 INT9230 Gene_expression of Htr3a 1 43 0.78 10.54 18.81
193 INT6807 Regulation of Gabrd 1 39 0.62 9.22 18.74
194 INT62577 Negative_regulation of Creb1 2 55 0.59 19.68 18.1
195 INT96532 Negative_regulation of Gene_expression of Slc1a2 2 24 0.59 14.22 17.91
196 INT29709 Positive_regulation of Gene_expression of Gria1 1 36 0.69 9.43 17.83
197 INT102903 Regulation of Gene_expression of Bdnf 2 35 0.62 20.1 17.42
198 INT95930 Negative_regulation of Gria2 1 63 0.56 18.37 17.04
199 INT109110 Positive_regulation of Pde5a 3 29 0.63 11.16 16.65
200 INT209 Positive_regulation of Pde5a 9 30 0.21 2.54 16.31
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