J:The Journal of General Physiology

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This page displays the top molecular interactions and top single events that were mentioned in the literature in this journal. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported in this journal. They are ordered first by their pain relevance and then by number of times they were reported in this journal. Text mining (TM) confidence, disease relevance and pain relevance are highlighted in green if they are judged to be high and red if not. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Reported in Journal Documents TM Confidence Disease Relevance Pain Relevance
1 INT208991 Binding of CALM1 and Ca2 10 3 0.06 1.34 1.55
2 INT254460 Binding of Calm2 and Ca2 5 7 0.03 0.48 0.43
3 INT316632 Dao Negative_regulation of Gopc 1 1 0.09 0 0.4
4 INT145682 Binding of P2rx4 and P2rx7 2 1 0.25 0.36 0.31
5 INT243151 P2ry4 Positive_regulation of P2rx6 1 1 0.00 0 0.3
6 INT304458 Binding of P2rx4 and P2rx6 1 2 0.14 0 0.17
7 INT304463 Ass1 Positive_regulation of P2rx4 1 2 0.01 0 0.14
8 INT250392 Binding of TRPV1 and TBA 1 1 0.01 0 0.12
9 INT304460 Ass1 Positive_regulation of Xist 1 1 0.00 0 0.09
10 INT304464 Binding of P2rx7 and P2rx6 1 1 0.05 0 0.09
11 INT239980 Ts3 Regulation of Nav1 1 1 0.12 0 0.09
12 INT304462 Binding of P2rx4 and P2rx5 1 1 0.17 0 0.08
13 INT243156 Positive_regulation of P2rx7 Positive_regulation of NOS1 1 1 0.00 0.08 0.08
14 INT304456 Binding of P2rx1 and P2rx4 1 1 0.14 0 0.07
15 INT170517 Binding of Ryr1 and Qdpr 2 3 0.15 0.36 0.05
16 INT304457 Ass1 Positive_regulation of Transcription of P2rx4 1 1 0.01 0 0.05
17 INT316648 Safb Positive_regulation of Car2 1 1 0.02 0 0
18 INT316649 Safb Positive_regulation of Localization of Car2 1 2 0.02 0 0
19 INT316647 Ryr1 Regulation of Qdpr 1 2 0.19 0.68 0
20 INT304461 Gopc Regulation of Gene_expression of P2rx3 1 1 0.09 0.07 0
21 INT298103 Binding of Cav1 and Ca2 1 1 0.03 0 0
22 INT298105 Ca2 Negative_regulation of Cd1d1 1 1 0.12 0.09 0
23 INT298104 Ca2 Negative_regulation of Cav1 1 1 0.04 0.09 0
24 INT304459 Gopc Regulation of Gene_expression of P2rx6 1 1 0.09 0.07 0
25 INT298124 Ca2 Negative_regulation of CALM1 1 2 0.00 0.17 0

Single Events

The table below shows the top 100 pain related interactions that have been reported in this journal. They are ordered first by their pain relevance and then by number of times they were reported in this journal. Text mining (TM) confidence, disease relevance and pain relevance are highlighted in green if they are judged to be high and red if not. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Reported in Journal Documents TM Confidence Disease Relevance Pain Relevance
1 INT58061 Gene_expression of Trpv1 1 1117 0.78 451.54 637.59
2 INT18357 Gene_expression of TRPV1 5 825 0.78 307.11 382.81
3 INT5680 Gene_expression of Ngf 8 530 0.78 264.29 310.56
4 INT46460 Gene_expression of NAV1 17 288 0.78 135.51 305.75
5 INT9131 Positive_regulation of Prkcg 1 431 0.70 130.8 302.41
6 INT97367 Gene_expression of Nav1 4 243 0.78 132.97 286.66
7 INT9381 Positive_regulation of TRPV1 2 523 0.70 187.4 276.05
8 INT94450 Gene_expression of Nav1 32 359 0.78 131.85 275.46
9 INT120811 Gene_expression of Gopc 10 1174 0.59 428.49 150.55
10 INT49134 Gene_expression of Grin1 1 270 0.78 84.78 148.61
11 INT1033 Positive_regulation of Ca2 1 507 0.68 131.76 147.64
12 INT812 Localization of INS 1 1026 0.81 515.6 145.31
13 INT65600 Positive_regulation of Casp3 1 376 0.70 198.44 128.03
14 INT7533 Gene_expression of Tlr4 1 720 0.78 343.22 121.57
15 INT85640 Gene_expression of Tg(CAG-EGFP)D4Nagy 2 1138 0.72 311.58 119.18
16 INT48593 Positive_regulation of NOS1 1 420 0.68 226.15 114.71
17 INT170025 Gene_expression of Fig4 9 588 0.67 183.27 113.32
18 INT3537 Positive_regulation of Car2 11 413 0.56 103.51 94.35
19 INT48767 Negative_regulation of NOS1 3 312 0.59 154.25 90.32
20 INT4830 Binding of Trpv1 1 158 0.48 45.11 84.2
21 INT16254 Positive_regulation of Gene_expression of Ngf 3 144 0.70 80.61 82.08
22 INT10534 Positive_regulation of Trib3 1 209 0.60 78.75 81.48
23 INT12476 Negative_regulation of TRPV1 3 124 0.59 47.95 77.98
24 INT17546 Negative_regulation of Ngf 6 135 0.59 60.28 77.19
25 INT12001 Regulation of Ngf 2 97 0.62 54.64 76.25
26 INT171145 Positive_regulation of Fig4 4 274 0.59 93.55 69.81
27 INT13286 Gene_expression of Ca2 3 317 0.67 71.58 65.01
28 INT1951 Positive_regulation of Tlr4 2 345 0.70 176.99 62.42
29 INT6623 Gene_expression of NA 1 231 0.78 45.78 59.36
30 INT169926 Positive_regulation of Gopc 5 416 0.46 157.8 58.67
31 INT83602 Positive_regulation of Gene_expression of TRPV1 1 114 0.70 51.19 56.35
32 INT49436 Binding of TRPV1 1 145 0.48 38.35 55.08
33 INT1032 Regulation of Ca2 7 202 0.52 54.91 53.03
34 INT49028 Positive_regulation of Nos1 2 102 0.70 34.73 51.05
35 INT9556 Negative_regulation of NAV1 7 47 0.59 28.49 49.33
36 INT111051 Negative_regulation of Nav1 3 64 0.59 25.51 47.27
37 INT170646 Negative_regulation of Fig4 4 213 0.37 81.29 46.92
38 INT30170 Gene_expression of Car2 4 330 0.66 77.26 46.76
39 INT9383 Localization of TRPV1 3 98 0.81 33.23 46.24
40 INT1322 Positive_regulation of Localization of INS 1 293 0.70 120.86 45.98
41 INT17561 Localization of Car2 24 303 0.79 60.95 44.52
42 INT170054 Negative_regulation of Gopc 9 280 0.38 117.89 42.4
43 INT81251 Gene_expression of Trpv2 1 78 0.78 28.27 41.76
44 INT173693 Localization of Gopc 5 249 0.65 70.49 38.81
45 INT116321 Regulation of Nav1 3 38 0.62 26.62 37.97
46 INT4449 Positive_regulation of NA 1 179 0.55 40.26 37.82
47 INT131413 Positive_regulation of Gene_expression of NAV1 4 35 0.70 17.5 36.83
48 INT64436 Gene_expression of P2rx1 12 93 0.78 32.69 36.12
49 INT5743 Localization of NA 1 104 0.59 14.35 35.29
50 INT111052 Positive_regulation of Gene_expression of Nav1 7 44 0.70 18.98 35.28
51 INT2274 Regulation of Localization of INS 1 101 0.62 41.55 34.79
52 INT103262 Localization of Nav1 3 53 0.81 19.23 34.44
53 INT70776 Positive_regulation of P2rx1 3 62 0.62 32.55 30.75
54 INT9133 Negative_regulation of Positive_regulation of Prkcg 1 37 0.59 10.95 30.06
55 INT32165 Binding of CALM1 1 92 0.48 24.19 29.57
56 INT65597 Negative_regulation of Casp3 1 69 0.59 39.19 29.32
57 INT65598 Negative_regulation of Positive_regulation of Casp3 1 45 0.59 18.36 28.59
58 INT66200 Gene_expression of Gfap 1 215 0.78 88.04 28.25
59 INT177581 Regulation of Fig4 2 113 0.41 39.26 27.75
60 INT123419 Binding of NAV1 2 37 0.48 7.09 26.43
61 INT136268 Localization of NAV1 1 22 0.75 2.84 26.23
62 INT116226 Regulation of NAV1 1 20 0.51 14.32 25.61
63 INT101225 Positive_regulation of Gria2 2 62 0.64 28.1 23.93
64 INT113925 Localization of Bdnf 1 59 0.79 24.03 22.76
65 INT17962 Regulation of Car2 3 124 0.41 33.98 22.71
66 INT88327 Gene_expression of P2rx7 8 109 0.77 48.86 22.41
67 INT1558 Positive_regulation of Dnahc8 1 30 0.69 5.78 22.19
68 INT23564 Negative_regulation of Car2 5 103 0.50 27.28 21.86
69 INT78057 Localization of Tlr4 2 140 0.77 67.75 21.72
70 INT1561 Negative_regulation of Dnahc8 1 59 0.59 18.12 20.99
71 INT105021 Binding of GOPC 1 187 0.40 60.39 20.38
72 INT91916 Gene_expression of P2rx3 5 51 0.78 21.2 19.05
73 INT145971 Localization of Nav1 1 20 0.81 10.3 18.11
74 INT6791 Binding of NA 1 55 0.46 5.36 17.59
75 INT111050 Negative_regulation of Gene_expression of Nav1 2 23 0.58 5.97 17.06
76 INT170051 Positive_regulation of Gene_expression of Gopc 1 150 0.43 56.75 16.93
77 INT14587 Positive_regulation of Cl 1 44 0.20 20.37 16.72
78 INT170033 Positive_regulation of Gene_expression of Fig4 3 59 0.43 20.99 16.69
79 INT113384 Regulation of Gene_expression of Nav1 4 20 0.62 8.57 16.15
80 INT62861 Regulation of Gria2 1 45 0.60 13.35 16.07
81 INT114507 Negative_regulation of Gene_expression of NAV1 5 17 0.43 7.24 15.93
82 INT85639 Positive_regulation of Tg(CAG-EGFP)D4Nagy 1 95 0.43 24.83 15.69
83 INT112207 Binding of Nav1 2 27 0.47 7.1 15.43
84 INT170855 Negative_regulation of GOPC 1 188 0.38 70.92 15.41
85 INT90942 Regulation of P2rx1 4 31 0.61 16.61 13.69
86 INT69166 Positive_regulation of P2ry1 2 35 0.67 8.41 13.63
87 INT121241 Positive_regulation of P2rx7 1 65 0.69 40.94 13.59
88 INT67653 Gene_expression of Om 1 46 0.36 15.28 13.32
89 INT19799 Binding of Ca2 1 71 0.48 13.69 12.92
90 INT91360 Negative_regulation of Slc12a2 2 16 0.54 10.46 12.89
91 INT174844 Binding of Fig4 3 81 0.41 18.03 12.87
92 INT122053 Positive_regulation of P2rx4 14 16 0.69 13.02 11.98
93 INT150851 Positive_regulation of Cxcl1 3 45 0.57 20.83 11.88
94 INT86698 Gene_expression of Cav1 5 38 0.78 16.37 11.75
95 INT119400 Phosphorylation of Car2 1 19 0.52 8.47 11.63
96 INT93122 Gene_expression of P2ry1 2 32 0.75 11.82 11.42
97 INT25170 Positive_regulation of Localization of Car2 10 78 0.67 15.25 11.24
98 INT43009 Gene_expression of Scn7a 7 45 0.68 7.85 10.29
99 INT178306 Negative_regulation of Gene_expression of Gopc 4 71 0.37 26.43 9.74
100 INT168991 Negative_regulation of P2rx4 3 9 0.43 12.77 9.39
101 INT1129 Binding of Car2 1 69 0.35 14.01 9.2
102 INT22771 Positive_regulation of Egf 2 44 0.70 16.45 8.64
103 INT136177 Gene_expression of P2rx4 25 8 0.75 6.74 8.05
104 INT25585 Positive_regulation of DNAH8 1 39 0.70 17.96 7.85
105 INT17028 Positive_regulation of Scn7a 17 35 0.41 9.83 7.44
106 INT111680 Gene_expression of P2ry2 3 20 0.58 9.23 7.39
107 INT17029 Regulation of Scn7a 4 23 0.45 3.89 7.02
108 INT93193 Positive_regulation of Accn2 1 16 0.69 7.2 6.37
109 INT113376 Transcription of Nav1 1 7 0.69 0.93 6.36
110 INT93195 Negative_regulation of Accn2 2 14 0.59 7.23 6.31
111 INT29556 Negative_regulation of CALM1 1 26 0.57 9.08 6.04
112 INT16573 Regulation of Cl 1 18 0.07 8.69 6.03
113 INT48911 Binding of NOS1 1 24 0.40 11.21 5.89
114 INT84572 Gene_expression of Zmat3 2 67 0.07 37.61 5.86
115 INT150853 Negative_regulation of Cxcl1 4 22 0.49 12.61 5.72
116 INT170516 Negative_regulation of Gene_expression of Car2 2 35 0.35 9.4 5.48
117 INT75800 Gene_expression of Cyp2a5 5 12 0.77 5.15 5.37
118 INT95696 Gene_expression of Dmd 9 130 0.68 26.02 5.34
119 INT146488 Gene_expression of Slc12a2 2 16 0.73 4.63 5.11
120 INT74051 Negative_regulation of Localization of Car2 2 27 0.38 9.58 5.1
121 INT145681 Regulation of P2rx4 10 4 0.61 3.41 5.09
122 INT115270 Positive_regulation of P2rx6 1 9 0.48 6.37 5.06
123 INT130203 Gene_expression of P2ry4 2 14 0.50 8.79 4.82
124 INT112038 Positive_regulation of P2ry2 1 8 0.45 2.41 4.4
125 INT76467 Regulation of Gene_expression of Car2 1 41 0.37 12.88 4.21
126 INT15001 Localization of Gfap 1 29 0.75 6.71 4.1
127 INT141443 Phosphorylation of Cav1 1 6 0.82 4.39 4.03
128 INT102850 Gene_expression of Trpv3 2 12 0.56 2.06 4.01
129 INT120715 Positive_regulation of Egfr 1 15 0.68 5.53 3.77
130 INT146946 Gene_expression of Lyn 3 16 0.76 8.9 3.75
131 INT170899 Negative_regulation of Positive_regulation of Gopc 1 16 0.19 5.46 3.71
132 INT192129 Gene_expression of P2rx2 1 24 0.67 7.62 3.68
133 INT134914 Binding of Gfap 1 21 0.37 8.25 3.67
134 INT29832 Negative_regulation of Scn7a 5 20 0.37 5.91 3.63
135 INT15002 Regulation of Gfap 1 17 0.37 5.34 3.61
136 INT18396 Positive_regulation of Ryr1 3 10 0.58 2.45 3.38
137 INT200872 Negative_regulation of Localization of Gopc 2 16 0.22 5.61 3.3
138 INT136651 Binding of Calm2 2 30 0.42 1.09 3.11
139 INT272358 Gene_expression of Adarb1 1 19 0.73 26.94 3.11
140 INT91918 Localization of P2rx3 1 10 0.72 3.16 2.82
141 INT149314 Negative_regulation of CAV2 1 5 0.42 1.21 2.76
142 INT136176 Positive_regulation of Gene_expression of P2rx4 6 5 0.60 3.18 2.64
143 INT196870 Positive_regulation of Phosphorylation of Car2 1 6 0.26 3.43 2.63
144 INT174876 Regulation of Gene_expression of Fig4 1 18 0.39 7.83 2.44
145 INT17559 Localization of Scn7a 1 13 0.28 4.47 2.37
146 INT211970 Negative_regulation of Best1 1 49 0.14 37.33 2.32
147 INT31796 Gene_expression of Enpep 1 5 0.65 0.42 2.32
148 INT37899 Positive_regulation of Calm2 1 10 0.58 0.53 2.27
149 INT146945 Positive_regulation of Lyn 3 6 0.49 2.81 2.25
150 INT136614 Positive_regulation of Cav1 1 5 0.46 2.28 2.23
151 INT51869 Negative_regulation of Dmd 3 24 0.52 10.4 2.18
152 INT14081 Regulation of Cyp2a5 1 11 0.50 7.91 2.18
153 INT144829 Localization of P2rx7 1 12 0.79 2.92 2.12
154 INT178339 Binding of Cxcl1 4 17 0.36 5.14 2.04
155 INT212124 Gene_expression of Cl 6 18 0.11 6.72 1.93
156 INT77072 Positive_regulation of Cyp2a5 1 18 0.56 15.47 1.92
157 INT165081 Positive_regulation of Positive_regulation of Accn2 1 3 0.49 2.79 1.9
158 INT102348 Regulation of P2ry2 1 6 0.40 2.18 1.79
159 INT84820 Negative_regulation of Negative_regulation of Ngf 1 5 0.59 2.5 1.79
160 INT227209 Negative_regulation of SCO 15 2 0.07 0.24 1.75
161 INT227759 Gene_expression of Best1 3 26 0.42 20.36 1.73
162 INT30168 Gene_expression of Dnahc8 2 20 0.65 4.17 1.73
163 INT87840 Positive_regulation of SCO 4 2 0.08 0.3 1.73
164 INT294504 Gene_expression of Safb 7 9 0.41 0.97 1.72
165 INT230716 Regulation of Binding of GOPC 1 2 0.10 0.26 1.59
166 INT125735 Transcription of P2rx7 1 3 0.62 1.34 1.58
167 INT316622 Gene_expression of Dao 3 4 0.52 1.27 1.57
168 INT23873 Regulation of Gm8644 1 2 0.16 0.27 1.54
169 INT114525 Negative_regulation of Positive_regulation of Egf 1 4 0.35 2.93 1.5
170 INT42250 Binding of Scn7a 1 7 0.33 0.51 1.48
171 INT151777 Regulation of Gene_expression of P2rx1 1 3 0.60 1.97 1.48
172 INT146941 Negative_regulation of Positive_regulation of P2rx4 2 2 0.37 1.36 1.47
173 INT304433 Localization of P2rx4 7 1 0.69 0 1.44
174 INT304444 Negative_regulation of Gene_expression of P2rx4 6 1 0.51 0.75 1.43
175 INT37900 Regulation of Calm2 3 9 0.36 0.52 1.4
176 INT136650 Gene_expression of Calm2 1 18 0.51 1.57 1.39
177 INT170507 Localization of Tmie 11 27 0.43 6.25 1.31
178 INT205952 Gene_expression of Shbdp1 2 14 0.24 2.46 1.27
179 INT16572 Localization of Cl 1 7 0.12 0.22 1.26
180 INT141862 Binding of Cav1 2 11 0.36 1.32 1.25
181 INT243771 Negative_regulation of Safb 5 7 0.26 0.77 1.23
182 INT216103 Positive_regulation of Dmd 3 15 0.46 5.92 1.21
183 INT233406 Localization of Cd2 1 4 0.44 0.13 1.2
184 INT32786 Localization of Enpep 1 4 0.68 0 1.16
185 INT152225 Regulation of Positive_regulation of Tlr4 1 8 0.53 2.5 1.12
186 INT182454 Binding of Tg(CAG-EGFP)D4Nagy 1 28 0.29 3.29 1.11
187 INT170511 Regulation of Localization of Car2 3 11 0.21 2.18 1.09
188 INT56023 Gene_expression of Porcn 1 4 0.16 0.73 1.08
189 INT231162 Localization of Dmd 4 6 0.71 2.27 1.07
190 INT196863 Positive_regulation of P2ry4 3 4 0.27 1.87 1.07
191 INT19803 Gene_expression of Hprt 1 15 0.67 4.81 1.03
192 INT230715 Regulation of KCNB1 1 1 0.14 0.64 1.02
193 INT160022 Transcription of Slc12a2 1 2 0.53 0.75 0.97
194 INT122073 Regulation of Regulation of Nav1 2 2 0.44 0.75 0.96
195 INT239978 Gene_expression of Ts3 5 1 0.64 0 0.95
196 INT111672 Gene_expression of Kcnq2 1 5 0.68 0.55 0.94
197 INT192123 Transcription of P2rx1 4 4 0.27 1.24 0.91
198 INT227201 Gene_expression of SCO 4 29 0.09 0.29 0.9
199 INT195946 Gene_expression of Hprt1 1 9 0.75 1.03 0.89
200 INT207496 Regulation of Gene_expression of Scn7a 1 8 0.04 1.1 0.89
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