J:The Open Biochemistry Journal

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This page displays the top molecular interactions and top single events that were mentioned in the literature in this journal. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported in this journal. They are ordered first by their pain relevance and then by number of times they were reported in this journal. Text mining (TM) confidence, disease relevance and pain relevance are highlighted in green if they are judged to be high and red if not. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Reported in Journal Documents TM Confidence Disease Relevance Pain Relevance
1 INT77646 Binding of Ngf and Ntrk1 23 1 0.40 7.85 9.26
2 INT106559 Binding of Bdnf and Ntrk2 23 1 0.43 11.09 7.33
3 INT88279 Ngf Positive_regulation of Ntrk1 5 1 0.76 3.06 5.23
4 INT165583 Binding of Bdnf and Ngf 3 1 0.33 0.81 0.69
5 INT308668 Akt1 Positive_regulation of Nos3 3 2 0.05 4.61 0.65
6 INT308656 Pik3r1 Positive_regulation of Nos3 1 2 0.02 1.8 0.5
7 INT197496 Binding of Apoe and Lrp1 4 4 0.22 2.32 0.46
8 INT308653 Proc Regulation of Gene_expression of Mapk8 1 1 0.00 1.48 0.36
9 INT308667 Binding of Chrm1 and Positive_regulation of Binding of App 1 2 0.04 1.14 0.32
10 INT255740 Pik3r1 Positive_regulation of Akt1 5 2 0.24 2.42 0.31
11 INT308661 Akt1 Positive_regulation of Chuk 1 1 0.02 0.6 0.25
12 INT308670 Positive_regulation of CYBB Positive_regulation of Gene_expression of Ros1 1 1 0.00 0.68 0.23
13 INT238802 Binding of Ager and Renbp 6 1 0.02 6.46 0.22
14 INT308650 Binding of nt and Ntrk2 1 1 0.01 0.41 0.21
15 INT308654 Binding of Ngfr and Nts 1 1 0.06 0.39 0.21
16 INT308645 Binding of Esr1 and Itpr3 1 1 0.00 0 0.2
17 INT308646 Car2 Regulation of Gene_expression of Ins1 1 1 0.00 0 0.19
18 INT308669 CREB1 Regulation of Gene_expression of Ins1 1 1 0.01 0 0.19
19 INT308657 Creb1 Regulation of Gene_expression of Ins1 1 1 0.01 0 0.19
20 INT308659 Binding of Ager and ecs 1 1 0.01 1.14 0.12
21 INT308647 Ager Positive_regulation of Gene_expression of Bace1 1 1 0.09 1.01 0.12
22 INT249923 Binding of Pah and Hif1a 1 2 0.31 1.16 0.12
23 INT308660 Binding of Ager and App 1 1 0.08 1.22 0.12
24 INT308651 Binding of Igf1 and Ins1 1 1 0.02 0.22 0.11
25 INT249925 Cpox Negative_regulation of Pah 1 1 0.01 0.18 0.1
26 INT308662 Binding of Esr1 and Fdft1 1 1 0.00 0.05 0.09
27 INT308666 Binding of Lrp1 and Chol1 1 2 0.10 0.69 0.09
28 INT308652 Binding of Renbp and Nps 1 1 0.01 1.38 0.09
29 INT249920 Negative_regulation of Binding of Pah and Hif1a 1 1 0.37 0.76 0.08
30 INT308655 Binding of Lrp1 and Gopc 1 1 0.01 0.49 0.07
31 INT308665 Binding of Apoe and Gopc 1 1 0.02 0.49 0.07
32 INT308663 Apoe Regulation of Car2 1 1 0.02 0.44 0.07
33 INT249958 Cpa1 Positive_regulation of NOS1 1 1 0.00 0.32 0.06
34 INT249955 Cpa1 Positive_regulation of Nos2 1 1 0.02 0.33 0.06
35 INT249954 Cpa1 Positive_regulation of Nos3 1 1 0.04 0.36 0.05
36 INT249922 Binding of Pah and Asph 1 1 0.06 0.4 0.04
37 INT308649 Binding of Ppp1r13b and Iars 1 1 0.01 0.29 0.04
38 INT249921 Binding of Hif1a and Asph 1 1 0.05 0.41 0.04
39 INT249959 Cpa1 Regulation of NOS1 1 1 0.00 0.08 0.04
40 INT308658 Binding of Apoa2 and Apoe 1 1 0.17 0.15 0.03
41 INT249961 Gatm Regulation of NOS1 1 1 0.00 0.07 0.03
42 INT121225 Positive_regulation of Ngf Positive_regulation of Ntrk1 2 1 0.49 0 0
43 INT249953 Cpa1 Regulation of Nos3 1 1 0.03 0.08 0
44 INT308648 Binding of sps and Gopc 1 1 0.01 2.71 0
45 INT249935 Nos3 Regulation of Nos2 1 2 0.25 0.19 0
46 INT308643 Binding of Proc and Renbp 1 1 0.00 1.61 0
47 INT249937 Nos1 Regulation of Nos3 1 2 0.23 0.19 0
48 INT249960 Arg1 Negative_regulation of NOS1 1 1 0.01 0.1 0
49 INT308664 Akt1 Positive_regulation of Phosphorylation of Insr 1 1 0.02 0.43 0
50 INT249924 Cpox Positive_regulation of Hif1a 1 1 0.01 0.68 0
51 INT249952 Cpa1 Regulation of Nos2 1 1 0.02 0.08 0
52 INT249934 Nos1 Regulation of Nos2 1 2 0.20 0.19 0

Single Events

The table below shows the top 100 pain related interactions that have been reported in this journal. They are ordered first by their pain relevance and then by number of times they were reported in this journal. Text mining (TM) confidence, disease relevance and pain relevance are highlighted in green if they are judged to be high and red if not. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Reported in Journal Documents TM Confidence Disease Relevance Pain Relevance
1 INT6483 Gene_expression of TNF 1 3152 0.78 2515.62 929.82
2 INT467 Gene_expression of POMC 1 1048 0.78 332.8 394.16
3 INT720 Positive_regulation of POMC 1 807 0.70 237.37 353.83
4 INT1352 Localization of Acot1 5 728 0.80 73.01 296.01
5 INT6852 Localization of TNF 1 883 0.81 705.95 270.84
6 INT9659 Gene_expression of Il6 2 991 0.78 715.11 265.57
7 INT68684 Gene_expression of VEGFA 7 2371 0.78 1742.52 259.2
8 INT95787 Positive_regulation of Mapk1 1 568 0.70 226.51 220.94
9 INT48955 Gene_expression of Nos2 4 753 0.78 403.87 208.08
10 INT24326 Gene_expression of Ngf 15 346 0.78 218.67 184.71
11 INT19472 Gene_expression of Il1 2 554 0.76 419.75 175.35
12 INT120811 Gene_expression of Gopc 1 1174 0.59 428.49 150.55
13 INT48953 Positive_regulation of Nos2 20 486 0.70 239.85 131.87
14 INT64161 Positive_regulation of Prkca 7 213 0.70 85.06 129.91
15 INT65054 Positive_regulation of Nfkb1 1 285 0.70 149.33 126.73
16 INT4259 Positive_regulation of Npr1 3 262 0.70 49.37 123.11
17 INT92669 Gene_expression of Bdnf 1 309 0.78 178.26 116.68
18 INT62124 Gene_expression of NOS1 3 444 0.78 218.08 114.85
19 INT48593 Positive_regulation of NOS1 5 420 0.68 226.15 114.71
20 INT27096 Positive_regulation of Nfkb1 1 325 0.70 195.11 109.06
21 INT49171 Gene_expression of Nos1 2 241 0.78 140.7 104.76
22 INT65500 Gene_expression of App 7 605 0.78 429.94 98.31
23 INT74058 Gene_expression of Nos1 1 260 0.78 80.04 95.71
24 INT3537 Positive_regulation of Car2 3 413 0.56 103.51 94.35
25 INT69764 Positive_regulation of Cnr1 1 126 0.70 67.8 91.49
26 INT48767 Negative_regulation of NOS1 1 312 0.59 154.25 90.32
27 INT74376 Gene_expression of Cnr1 2 173 0.78 73.43 89.7
28 INT82448 Gene_expression of S100a8 1 246 0.77 236.72 84.02
29 INT56291 Gene_expression of Ros1 3 503 0.63 274.12 81.5
30 INT3214 Localization of Ins1 4 527 0.80 196.9 79.26
31 INT1353 Negative_regulation of Localization of Acot1 4 153 0.53 15.05 75.17
32 INT12720 Positive_regulation of Il1 1 246 0.70 195.97 72.05
33 INT50971 Gene_expression of Ntrk1 4 180 0.75 73.52 62.28
34 INT103924 Positive_regulation of Akt1 9 359 0.69 158.94 60.34
35 INT79093 Positive_regulation of Nos1 2 101 0.70 46.89 59.61
36 INT62960 Gene_expression of P2rx2 3 149 0.77 58.31 59.16
37 INT64159 Gene_expression of Prkca 2 90 0.78 34.65 55.97
38 INT3213 Gene_expression of Ins1 14 511 0.76 357.59 53.32
39 INT48952 Negative_regulation of Nos2 10 204 0.59 101.73 53.15
40 INT27954 Positive_regulation of Gene_expression of Ngf 1 87 0.70 57.91 51.96
41 INT64110 Positive_regulation of Gene_expression of Nos1 1 68 0.70 58.11 51.64
42 INT83199 Gene_expression of Nos3 3 193 0.78 100.72 51.57
43 INT49028 Positive_regulation of Nos1 1 102 0.70 34.73 51.05
44 INT19775 Localization of Il1 1 183 0.78 145.5 50.91
45 INT106525 Phosphorylation of Akt1 2 436 0.82 183.81 47.82
46 INT170646 Negative_regulation of Fig4 1 213 0.37 81.29 46.92
47 INT25610 Positive_regulation of Gene_expression of Il1 1 136 0.67 104.43 43.86
48 INT52531 Gene_expression of Nfkb1 3 153 0.75 82.84 42.9
49 INT57442 Phosphorylation of Prkca 1 98 0.70 31.58 41.04
50 INT97596 Localization of S100a8 3 94 0.78 90.69 40.41
51 INT47939 Gene_expression of Selp 1 171 0.76 87.54 39.03
52 INT20210 Localization of Ngf 2 69 0.79 46.22 38.57
53 INT104551 Gene_expression of Il18 1 156 0.76 115.51 36.95
54 INT64558 Negative_regulation of Nos1 2 88 0.58 26.76 36.78
55 INT1354 Negative_regulation of Acot1 2 87 0.43 15.01 36.44
56 INT8747 Positive_regulation of Ins1 2 221 0.69 154.28 35.15
57 INT12161 Positive_regulation of P2rx2 1 70 0.69 34.22 34.4
58 INT14559 Gene_expression of Igf1 3 254 0.78 112 34.17
59 INT65536 Negative_regulation of Positive_regulation of Nfkb1 1 77 0.59 38.86 33.33
60 INT96913 Positive_regulation of Mapk8 2 179 0.69 130.44 32.2
61 INT114881 Gene_expression of Akt1 3 227 0.78 102.49 31.81
62 INT124860 Gene_expression of Bace1 1 330 0.78 157.11 31.65
63 INT29743 Negative_regulation of App 1 91 0.59 65.56 31.26
64 INT64164 Regulation of Prkca 3 34 0.62 10.44 30.99
65 INT151111 Gene_expression of Pain1 6 33 0.40 33.6 30.73
66 INT47712 Positive_regulation of App 2 135 0.69 101.38 28.94
67 INT6364 Gene_expression of Edn1 4 123 0.78 73.76 28.43
68 INT133876 Positive_regulation of Gene_expression of Ros1 1 141 0.32 75.55 27.45
69 INT37296 Binding of Esr1 1 117 0.43 62.51 27.33
70 INT3217 Regulation of Ins1 3 154 0.62 87.11 27.29
71 INT116861 Gene_expression of Apoe 3 182 0.78 100.41 27.26
72 INT145426 Positive_regulation of Ros1 1 185 0.56 106.76 27.21
73 INT4735 Gene_expression of Acot1 1 80 0.71 13.22 26.68
74 INT605 Regulation of Acot1 2 61 0.62 10.7 26.34
75 INT86062 Positive_regulation of Tnfrsf1a 1 51 0.69 40.69 26.2
76 INT63769 Regulation of Ngf 1 44 0.62 21.82 25.84
77 INT89662 Positive_regulation of Gene_expression of App 2 169 0.70 133.36 25.62
78 INT61953 Transcription of Nos2 1 101 0.72 46.64 25.49
79 INT48766 Regulation of NOS1 5 73 0.61 37.01 24.59
80 INT48240 Binding of Ngf 1 46 0.46 23.51 24.42
81 INT70503 Regulation of Gene_expression of Nos2 1 71 0.62 44 24.01
82 INT93738 Gene_expression of Tnfrsf1a 1 63 0.74 57.66 23.09
83 INT113925 Localization of Bdnf 1 59 0.79 24.03 22.76
84 INT17962 Regulation of Car2 1 124 0.41 33.98 22.71
85 INT18322 Negative_regulation of Ins1 4 132 0.58 88.49 22.59
86 INT1558 Positive_regulation of Dnahc8 1 30 0.69 5.78 22.19
87 INT45437 Localization of Acot1 1 84 0.79 17.37 22.18
88 INT1561 Negative_regulation of Dnahc8 1 59 0.59 18.12 20.99
89 INT112029 Positive_regulation of Pik3r1 3 90 0.67 38.76 20.95
90 INT11625 Localization of App 5 98 0.78 55.46 20.86
91 INT68683 Regulation of Gene_expression of VEGFA 1 143 0.62 104.19 20.14
92 INT95318 Binding of Pain1 7 17 0.22 21.26 20.14
93 INT46016 Gene_expression of Ngfr 1 69 0.77 41.22 19.8
94 INT16794 Binding of App 2 103 0.48 64.87 19.79
95 INT65502 Regulation of App 2 77 0.62 52.05 19.44
96 INT83198 Positive_regulation of Nos3 15 78 0.64 35.69 17.71
97 INT24225 Gene_expression of Alms1 1 93 0.62 52.75 16.93
98 INT145097 Negative_regulation of Pain1 4 16 0.22 19.11 16.82
99 INT61949 Regulation of Nos2 5 74 0.58 34.08 16.7
100 INT8742 Regulation of Localization of Ins1 1 65 0.61 14.98 16.43
101 INT112027 Gene_expression of Pik3r1 2 58 0.75 30.9 15.95
102 INT91285 Negative_regulation of P2rx2 2 29 0.57 12.74 15.48
103 INT61635 Positive_regulation of P2ry2 1 35 0.56 12.08 14.68
104 INT167521 Regulation of Pain1 4 11 0.27 10.88 14
105 INT36177 Binding of Alms1 1 70 0.31 35.47 13.81
106 INT114420 Negative_regulation of Pik3r1 1 67 0.54 34.86 12.82
107 INT2129 Positive_regulation of F2 1 83 0.70 58.95 12.63
108 INT156696 Positive_regulation of Pain1 3 10 0.23 10.92 12.42
109 INT107916 Protein_catabolism of App 2 114 1.00 66.71 12.38
110 INT100821 Localization of Ros1 2 59 0.60 45.26 11.92
111 INT66038 Positive_regulation of Ngfr 1 32 0.69 26.07 11.75
112 INT109315 Gene_expression of Mapk8 1 70 0.78 45.46 11.65
113 INT119400 Phosphorylation of Car2 1 19 0.52 8.47 11.63
114 INT73431 Positive_regulation of Nos3 2 82 0.65 53.22 11.61
115 INT65501 Regulation of Gene_expression of App 3 56 0.62 32.51 11.48
116 INT4498 Gene_expression of F2 2 83 0.65 57.4 10.8
117 INT62576 Transcription of Creb1 1 34 0.69 16.97 10.6
118 INT3982 Gene_expression of Acot1 2 53 0.56 7.61 10.46
119 INT25613 Gene_expression of Il1f5 1 32 0.77 13.29 10.44
120 INT86361 Positive_regulation of Positive_regulation of NOS1 2 39 0.53 18.93 10.42
121 INT27955 Negative_regulation of Gene_expression of Ngf 2 16 0.59 10.43 10.17
122 INT35284 Positive_regulation of Chrm1 1 14 0.67 5.64 10.11
123 INT102865 Positive_regulation of Positive_regulation of Prkca 1 25 0.69 8.34 9.9
124 INT95271 Negative_regulation of Nos3 15 46 0.53 24.1 9.71
125 INT75137 Regulation of Akt1 1 74 0.48 37.89 9.7
126 INT6361 Localization of Edn1 1 30 0.81 19.09 9.7
127 INT116705 Positive_regulation of Positive_regulation of P2rx2 1 13 0.49 9.44 9.47
128 INT17101 Positive_regulation of Gene_expression of Edn1 1 24 0.69 24.9 8.86
129 INT22965 Positive_regulation of Pah 1 42 0.61 41.41 8.84
130 INT12095 Negative_regulation of Edn1 2 26 0.59 12.01 8.79
131 INT104396 Positive_regulation of Positive_regulation of Akt1 1 44 0.55 14.78 8.69
132 INT224366 Gene_expression of Ager 3 111 0.77 125.37 8.49
133 INT109005 Gene_expression of Proc 2 61 0.75 37.86 8.49
134 INT18583 Positive_regulation of Gene_expression of Ins1 2 67 0.50 49.72 8.26
135 INT72337 Positive_regulation of Positive_regulation of Nos2 5 37 0.65 17.02 8.11
136 INT5114 Gene_expression of Ptgis 1 41 0.50 21.43 8.1
137 INT51458 Negative_regulation of Gene_expression of Selp 1 29 0.57 12.64 8.1
138 INT62400 Positive_regulation of Localization of Il1 1 34 0.67 35.53 7.96
139 INT22056 Positive_regulation of CYBB 2 88 0.68 32.13 7.95
140 INT18025 Binding of Pah 1 32 0.45 30.72 7.93
141 INT1150 Gene_expression of ecs 4 42 0.59 29.38 7.73
142 INT17501 Negative_regulation of F2 9 70 0.58 32.23 7.51
143 INT182750 Gene_expression of Hmgcr 1 61 0.58 17.23 7.4
144 INT103925 Negative_regulation of Positive_regulation of Akt1 1 32 0.58 15.19 7.39
145 INT524 Positive_regulation of Cpa1 2 12 0.39 4.74 7.38
146 INT197493 Localization of Apoe 2 61 0.79 27.48 7.06
147 INT32783 Gene_expression of Pah 1 33 0.60 30.55 6.86
148 INT142344 Transcription of Igf1 1 22 0.69 7.55 6.77
149 INT83712 Transcription of Nos3 1 19 0.69 13.09 6.31
150 INT49468 Negative_regulation of Pah 7 28 0.55 24.95 6.29
151 INT11814 Positive_regulation of Alb 2 43 0.63 31.71 6.28
152 INT93658 Transcription of Nos1 1 16 0.72 6.85 6.16
153 INT114882 Positive_regulation of Gene_expression of Akt1 1 45 0.69 21.29 6.06
154 INT63042 Binding of Apoe 5 59 0.48 31.23 5.88
155 INT113700 Positive_regulation of Chuk 2 30 0.41 21.17 5.69
156 INT35248 Gene_expression of Gpi 1 14 0.51 2.38 5.49
157 INT112713 Gene_expression of Hif1a 3 24 0.75 20.48 5.45
158 INT74250 Negative_regulation of Gene_expression of Ins1 2 47 0.40 39.27 5.37
159 INT107173 Phosphorylation of App 1 20 0.82 12.64 5.3
160 INT3215 Regulation of Gene_expression of Ins1 2 32 0.52 19.83 4.85
161 INT116748 Positive_regulation of Gene_expression of Pik3r1 1 18 0.49 9.83 4.63
162 INT230810 Phosphorylation of Ins1 1 59 0.69 41.15 4.51
163 INT14557 Negative_regulation of Igf1 2 96 0.59 54.83 4.45
164 INT122569 Negative_regulation of Gene_expression of Akt1 4 34 0.54 17.15 4.44
165 INT93739 Positive_regulation of Gene_expression of Tnfrsf1a 1 11 0.66 11.17 4.44
166 INT9842 Binding of F2 6 36 0.47 22.79 4.42
167 INT76581 Regulation of Negative_regulation of NOS1 1 14 0.45 7.49 4.4
168 INT81750 Regulation of Ntrk1 1 13 0.52 6.03 4.37
169 INT116747 Regulation of Pik3r1 1 18 0.60 9.33 4.34
170 INT45433 Positive_regulation of Localization of Acot1 1 18 0.45 1.9 4.32
171 INT112704 Positive_regulation of Hif1a 9 25 0.67 21.49 4.23
172 INT230796 Phosphorylation of Irs1 2 70 0.81 31.73 4.13
173 INT83991 Regulation of Nos3 6 25 0.44 9.89 4.06
174 INT224369 Binding of Ager 2 43 0.42 40.57 3.86
175 INT73602 Positive_regulation of Ager 1 35 0.69 30.66 3.74
176 INT131877 Negative_regulation of Nps 1 12 0.39 8.19 3.56
177 INT41490 Regulation of Acot1 1 14 0.45 1.59 3.34
178 INT194625 Gene_expression of GSK 1 18 0.75 9.02 3.23
179 INT118153 Regulation of Positive_regulation of Prkca 1 5 0.45 3.15 3.23
180 INT165911 Localization of Pik3r1 1 15 0.51 7.94 3.2
181 INT81830 Localization of P2rx2 2 14 0.73 5.42 3.16
182 INT35143 Negative_regulation of ANGPTL5 1 28 0.54 18.59 3.14
183 INT110755 Negative_regulation of Positive_regulation of Mapk8 1 15 0.46 9.91 2.98
184 INT123466 Binding of T2dm2 1 21 0.37 34.87 2.91
185 INT28891 Localization of Selp 1 13 0.60 8.23 2.83
186 INT29651 Regulation of Pah 1 11 0.37 9.95 2.79
187 INT91284 Negative_regulation of P2ry2 1 8 0.25 2.66 2.71
188 INT39469 Negative_regulation of Alb 2 21 0.41 13.33 2.68
189 INT134756 Positive_regulation of Gene_expression of Hif1a 1 8 0.50 11.14 2.68
190 INT72757 Negative_regulation of Negative_regulation of Nos2 1 8 0.42 4.23 2.68
191 INT71794 Binding of SERPINC1 1 17 0.39 10.5 2.64
192 INT8782 Regulation of Gpi 1 5 0.28 1.63 2.51
193 INT136850 Positive_regulation of Arg1 1 10 0.50 6.96 2.47
194 INT190081 Gene_expression of Abca1 1 21 0.65 18.18 2.45
195 INT109305 Phosphorylation of Pik3r1 1 13 0.53 5.69 2.32
196 INT142265 Regulation of Apoe 1 20 0.60 9.52 2.23
197 INT138286 Regulation of Positive_regulation of Akt1 1 13 0.45 4.93 2.22
198 INT55291 Gene_expression of Slc2a1 1 20 0.68 11.46 2.16
199 INT28739 Binding of Ins1 3 35 0.37 22.43 2.14
200 INT114421 Positive_regulation of Positive_regulation of Pik3r1 1 9 0.49 4.07 2.13
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