J:The Open Cardiovascular Medicine Journal

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This page displays the top molecular interactions and top single events that were mentioned in the literature in this journal. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported in this journal. They are ordered first by their pain relevance and then by number of times they were reported in this journal. Text mining (TM) confidence, disease relevance and pain relevance are highlighted in green if they are judged to be high and red if not. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Reported in Journal Documents TM Confidence Disease Relevance Pain Relevance
1 INT66504 Binding of Agt and Agtr1a 8 2 0.39 3.78 1.78
2 INT250016 Binding of IGHE and Il13 1 3 0.01 4.59 0.97
3 INT302379 Crp Positive_regulation of Gene_expression of Ccl2 1 2 0.10 4.58 0.84
4 INT154755 Tnf Positive_regulation of Gene_expression of Ccl2 2 1 0.23 1.7 0.27
5 INT229360 Agt Positive_regulation of Agtr1a 2 1 0.48 1.26 0.2
6 INT249993 Binding of Agt and Igkv4-55 1 2 0.02 0.49 0.2
7 INT250003 Binding of IGHE and IL13 1 1 0.03 1.16 0.18
8 INT249962 Binding of KIT and KITLG 6 1 0.19 3.69 0.17
9 INT302381 Il33 Regulation of Gene_expression of Il4 1 1 0.01 0.76 0.16
10 INT293712 Binding of Adra2a and Atl1 1 1 0.06 0.83 0.15
11 INT302384 IL6 Positive_regulation of Localization of Crp 1 1 0.10 1.39 0.15
12 INT302385 Il1b Positive_regulation of Nfib Positive_regulation of Gene_expression of Ccl2 1 1 0.00 1.48 0.09
13 INT302382 Il1b Positive_regulation of Gene_expression of Ccl2 1 1 0.00 1.39 0.09
14 INT302380 Tnf Positive_regulation of Nfib 1 1 0.00 1.41 0.09
15 INT302383 Il1b Positive_regulation of Nfib 1 1 0.00 1.42 0.09
16 INT249994 Binding of Agtr1a and Igkv4-55 1 1 0.01 0.38 0.08
17 INT250024 Positive_regulation of Ros1 Positive_regulation of Gtf3a 1 1 0.00 1.26 0.08
18 INT250023 Positive_regulation of Ros1 Positive_regulation of Nfkb1 1 1 0.04 1.26 0.08
19 INT249968 Cxcr4 Positive_regulation of Cxcl12 1 1 0.17 0.55 0.08
20 INT249987 Agt Negative_regulation of Lnpep 1 1 0.11 0.53 0.07
21 INT356379 DMD Positive_regulation of Negative_regulation of Utrn 1 1 0.54 0.84 0.07
22 INT250015 Binding of FLNA and Nos3 1 1 0.05 1.09 0.06
23 INT249988 Agt Regulation of Ca2 1 2 0.18 0.9 0.04
24 INT249991 Agt Regulation of Fig4 1 1 0.12 0.57 0.04
25 INT249990 Agt Positive_regulation of Positive_regulation of Ca2 1 1 0.20 0.65 0.04
26 INT249989 Agt Positive_regulation of Ca2 1 2 0.20 1.6 0.04
27 INT250025 Map3k1 Positive_regulation of Regulation of Bcl2 1 1 0.01 1.1 0.04
28 INT249992 Binding of Lnpep and Igkv4-55 1 1 0.01 0.47 0
29 INT249996 Binding of ICAM1 and GPHA2 1 3 0.02 2.25 0
30 INT249995 Positive_regulation of Binding of ICAM1 and GPHA2 1 3 0.02 2.43 0
31 INT356377 Dmd Positive_regulation of Negative_regulation of Mib2 1 1 0.03 0.51 0

Single Events

The table below shows the top 100 pain related interactions that have been reported in this journal. They are ordered first by their pain relevance and then by number of times they were reported in this journal. Text mining (TM) confidence, disease relevance and pain relevance are highlighted in green if they are judged to be high and red if not. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Reported in Journal Documents TM Confidence Disease Relevance Pain Relevance
1 INT6483 Gene_expression of TNF 4 3152 0.78 2515.62 929.82
2 INT9238 Gene_expression of IL6 1 1575 0.78 1135.66 424.22
3 INT5059 Positive_regulation of TNF 2 1050 0.70 896.51 322.81
4 INT9131 Positive_regulation of Prkcg 1 431 0.70 130.8 302.41
5 INT63932 Positive_regulation of Ephb1 2 537 0.70 259.67 296.14
6 INT6852 Localization of TNF 2 883 0.81 705.95 270.84
7 INT22548 Positive_regulation of Casp3 4 483 0.70 258.78 213.07
8 INT48955 Gene_expression of Nos2 3 753 0.78 403.87 208.08
9 INT6488 Gene_expression of Tnf 1 484 0.78 339.61 191.58
10 INT10194 Positive_regulation of IL6 1 702 0.70 600.62 183.38
11 INT15516 Gene_expression of Crp 4 711 0.77 615.33 173.09
12 INT1114 Localization of Ins1 2 748 0.80 192.95 165.48
13 INT1303 Negative_regulation of Npr1 1 278 0.55 35.1 156.78
14 INT15515 Positive_regulation of Crp 7 700 0.70 604.24 150.15
15 INT1033 Positive_regulation of Ca2 5 507 0.68 131.76 147.64
16 INT48953 Positive_regulation of Nos2 3 486 0.70 239.85 131.87
17 INT4259 Positive_regulation of Npr1 1 262 0.70 49.37 123.11
18 INT14151 Gene_expression of Casp3 1 311 0.78 140.26 120.68
19 INT20374 Gene_expression of Il4 1 515 0.76 306.15 114.12
20 INT49171 Gene_expression of Nos1 1 241 0.78 140.7 104.76
21 INT18009 Positive_regulation of CRP 1 518 0.70 553.03 103.74
22 INT10838 Positive_regulation of IL8 1 381 0.70 295.51 101.62
23 INT4822 Localization of Ca2 1 417 0.80 99.57 96.45
24 INT10534 Positive_regulation of Trib3 2 209 0.60 78.75 81.48
25 INT3657 Gene_expression of Ins1 2 514 0.78 321.69 75.76
26 INT5056 Gene_expression of IFNG 1 216 0.78 137.52 74.57
27 INT1724 Negative_regulation of ACE 1 437 0.59 315.64 74.48
28 INT12536 Localization of Prkcg 1 101 0.80 36.37 73.81
29 INT11380 Negative_regulation of IL1B 1 215 0.59 125.62 72.35
30 INT102546 Gene_expression of Ccl2 4 197 0.78 192.8 67.41
31 INT3375 Gene_expression of IGHE 3 535 0.77 387.47 65.46
32 INT11318 Gene_expression of Gtf3a 2 274 0.52 183.82 60.89
33 INT49170 Negative_regulation of Nos1 2 116 0.59 60.66 58.87
34 INT11491 Positive_regulation of KNG1 1 128 0.67 60.41 58.74
35 INT6477 Gene_expression of IL1RN 2 213 0.77 114.69 58.62
36 INT1200 Negative_regulation of Ins1 2 274 0.58 155.17 56.14
37 INT314 Positive_regulation of Ren 1 212 0.70 66.68 55.56
38 INT96914 Phosphorylation of Mapk14 1 168 0.82 108.46 53.32
39 INT48952 Negative_regulation of Nos2 1 204 0.59 101.73 53.15
40 INT64110 Positive_regulation of Gene_expression of Nos1 1 68 0.70 58.11 51.64
41 INT1199 Positive_regulation of INS 1 579 0.70 399.64 50.43
42 INT22454 Regulation of Crp 3 213 0.62 160.67 49.24
43 INT671 Positive_regulation of Cea 1 221 0.69 164.5 47.79
44 INT110023 Negative_regulation of Mapk14 1 127 0.59 84.27 45.42
45 INT2774 Binding of Crp 4 241 0.48 195.89 44.39
46 INT100939 Gene_expression of Il13 1 176 0.73 125.1 43.38
47 INT157666 Positive_regulation of GOPC 1 335 0.60 120.19 42.75
48 INT48929 Regulation of Ephb1 1 71 0.62 24.42 42.11
49 INT350 Localization of Th 1 79 0.80 10.26 41.17
50 INT3987 Positive_regulation of IGHE 1 316 0.70 283.2 40.16
51 INT9094 Gene_expression of COL7A1 1 277 0.77 143.42 38.73
52 INT385 Gene_expression of Agt 9 182 0.78 63.62 37.91
53 INT11439 Positive_regulation of Csf2 1 105 0.69 62.63 37.77
54 INT62827 Positive_regulation of ICAM1 1 184 0.70 180.95 36.28
55 INT62827 Positive_regulation of ICAM1 3 184 0.70 180.95 36.28
56 INT101992 Localization of VEGFA 1 413 0.81 258.23 36.15
57 INT390 Positive_regulation of Agt 9 170 0.70 61.47 36.08
58 INT51017 Positive_regulation of Icam1 1 113 0.70 81.16 35.55
59 INT60710 Gene_expression of Col7a1 1 217 0.78 113.2 35.2
60 INT7608 Positive_regulation of Adra2a 9 66 0.70 17.81 35.15
61 INT1624 Gene_expression of Cea 2 212 0.76 180.44 34.21
62 INT12537 Positive_regulation of Localization of Prkcg 1 36 0.70 14.57 33.81
63 INT63933 Negative_regulation of Positive_regulation of Ephb1 1 53 0.58 22.83 33.43
64 INT40160 Positive_regulation of Adora1 5 74 0.70 26.36 33.03
65 INT48693 Regulation of VEGFA 1 268 0.62 191.88 31.52
66 INT1179 Negative_regulation of Ace 1 157 0.59 67.03 30.46
67 INT1158 Regulation of Agt 2 106 0.61 29.4 30.29
68 INT68973 Positive_regulation of Mmp9 2 89 0.52 58.56 30.04
69 INT6624 Gene_expression of Pth 2 135 0.76 110.27 27.54
70 INT21687 Positive_regulation of ras 4 143 0.58 97.34 27.31
71 INT21687 Positive_regulation of ras 4 143 0.58 97.34 27.31
72 INT69157 Gene_expression of IL5 1 127 0.77 102.58 26.81
73 INT12681 Regulation of Trib3 1 76 0.53 23.92 26.58
74 INT68758 Positive_regulation of Ros1 2 125 0.46 82.72 25.27
75 INT73670 Gene_expression of Vcam1 1 128 0.78 123.79 24.96
76 INT100423 Gene_expression of Bax 1 141 0.75 98.43 24.48
77 INT6726 Positive_regulation of Edn1 1 118 0.70 65.96 24.07
78 INT70503 Regulation of Gene_expression of Nos2 1 71 0.62 44 24.01
79 INT96741 Gene_expression of Cxcr4 1 62 0.78 32.3 22.14
80 INT35711 Positive_regulation of Sdcbp 2 110 0.60 50.45 22.11
81 INT74682 Positive_regulation of Mmp2 2 72 0.69 40.46 21.73
82 INT171820 Localization of Fig4 1 144 0.65 27.38 20.88
83 INT5096 Positive_regulation of Gtf3a 4 79 0.60 42.26 20.62
84 INT3030 Gene_expression of Adra2a 1 37 0.68 5.58 19.76
85 INT4260 Negative_regulation of Positive_regulation of Npr1 1 29 0.43 4.39 19.57
86 INT77675 Gene_expression of Saa 1 40 0.58 43.37 18.69
87 INT20260 Positive_regulation of Chkb 2 41 0.64 21.48 18.53
88 INT28642 Gene_expression of CXCR2 2 60 0.78 38.69 18.11
89 INT27670 Negative_regulation of Ace 3 122 0.57 79.21 18.08
90 INT113602 Positive_regulation of Gene_expression of Ccl2 1 48 0.70 48.71 17.85
91 INT111531 Negative_regulation of Phosphorylation of Mapk14 1 37 0.50 20 17.68
92 INT32515 Negative_regulation of B4GALNT1 1 82 0.43 28.1 17.46
93 INT61513 Positive_regulation of Gpx1 1 71 0.64 37.91 17.07
94 INT38056 Localization of Crp 1 71 0.78 53.14 17.03
95 INT2066 Localization of Agt 5 56 0.80 9.95 16.25
96 INT9525 Regulation of Positive_regulation of Prkcg 1 20 0.62 7.82 16.18
97 INT16167 Negative_regulation of DMD 5 186 0.57 108.71 15.25
98 INT16166 Positive_regulation of DMD 3 348 0.67 133.22 15.06
99 INT74449 Positive_regulation of B4GALNT1 1 53 0.30 34.49 14.96
100 INT133549 Gene_expression of Il15 2 42 0.69 27.84 14.74
101 INT35120 Gene_expression of Sdcbp 2 68 0.67 21.33 13.96
102 INT79703 Gene_expression of Agtr1a 2 46 0.76 14.18 13.77
103 INT24684 Localization of PLAT 1 30 0.78 26.21 13.56
104 INT87235 Negative_regulation of Il4 1 54 0.48 31.51 13.15
105 INT2578 Binding of Ins1 1 74 0.48 33.57 12.92
106 INT174844 Binding of Fig4 2 81 0.41 18.03 12.87
107 INT50227 Positive_regulation of Adora2a 2 32 0.50 5.17 12.75
108 INT4199 Binding of Agt 1 76 0.48 21.06 12.66
109 INT4199 Binding of Agt 11 76 0.48 21.06 12.66
110 INT8629 Positive_regulation of COL7A1 1 72 0.69 40.66 12.09
111 INT3074 Negative_regulation of Chkb 1 29 0.57 14 12.04
112 INT41313 Gene_expression of Gpx1 2 68 0.78 34.24 11.77
113 INT53038 Positive_regulation of Agtr1a 2 35 0.67 23.76 11.68
114 INT1190 Positive_regulation of F2 1 53 0.70 46.41 11.64
115 INT6474 Positive_regulation of Gene_expression of IL1RN 2 34 0.69 21.87 10.99
116 INT222233 Gene_expression of Cxcl12 2 42 0.69 32.64 10.13
117 INT76573 Negative_regulation of Vcam1 1 26 0.58 24.36 9.84
118 INT3988 Positive_regulation of Gene_expression of IGHE 1 98 0.68 91.46 9.61
119 INT149069 Positive_regulation of Cxcr4 1 24 0.68 12.21 9.54
120 INT102110 Positive_regulation of Gene_expression of Bax 1 42 0.67 35.77 9.51
121 INT56985 Gene_expression of MEFV 2 56 0.71 46.71 9.47
122 INT135407 Negative_regulation of Ccl2 1 33 0.57 32.74 9.45
123 INT20664 Binding of ACE 1 60 0.48 35.27 9.16
124 INT62829 Positive_regulation of VCAM1 1 39 0.70 38.42 9.15
125 INT138700 Negative_regulation of Gene_expression of Ccl2 1 27 0.57 24.1 9.08
126 INT69264 Gene_expression of KIT 1 207 0.78 179.41 8.95
127 INT22083 Regulation of Pth 1 55 0.62 22.32 8.9
128 INT55597 Negative_regulation of Gpx1 1 59 0.55 28.3 8.83
129 INT113845 Protein_catabolism of PARP1 3 54 0.88 43.86 8.77
130 INT386 Positive_regulation of Gene_expression of Agt 2 37 0.70 15.92 8.73
131 INT81444 Positive_regulation of Gene_expression of Vcam1 1 40 0.70 46.38 8.58
132 INT148703 Gene_expression of NOVA2 1 73 0.65 18.05 8.3
133 INT6625 Negative_regulation of Pth 1 96 0.58 57.6 8.24
134 INT126583 Positive_regulation of PARP1 1 50 0.68 41.44 7.78
135 INT98178 Localization of Casp3 1 32 0.65 21.01 7.77
136 INT21685 Gene_expression of ras 2 115 0.66 85.6 7.76
137 INT65246 Negative_regulation of Nos3 1 36 0.50 25.65 7.62
138 INT8684 Positive_regulation of ANGPTL5 1 45 0.69 36.29 7.47
139 INT1771 Positive_regulation of Ace 1 31 0.68 10.47 7.46
140 INT91445 Regulation of Bcl2 1 50 0.56 38.8 7.41
141 INT91509 Localization of CYC1 2 39 0.78 34.74 7.17
142 INT29583 Positive_regulation of Agtr2 1 30 0.45 21.47 7.04
143 INT16997 Binding of PRTN3 2 34 0.48 33.44 6.45
144 INT138833 Binding of MTHFR 1 12 0.46 16.08 6.4
145 INT127023 Negative_regulation of Gene_expression of Vcam1 1 24 0.59 20.39 6.28
146 INT65265 Positive_regulation of Gene_expression of Col7a1 1 48 0.69 23.81 6.16
147 INT2137 Localization of Cea 3 27 0.70 19.22 6.14
148 INT19916 Gene_expression of GPHA2 3 18 0.48 9.78 6.04
149 INT64111 Negative_regulation of Gene_expression of Nos1 1 22 0.57 8.96 6.02
150 INT96744 Positive_regulation of Gene_expression of Cxcr4 1 14 0.68 7.92 5.75
151 INT136309 Positive_regulation of Cxcl12 1 24 0.62 12.45 5.58
152 INT13396 Gene_expression of DMD 12 125 0.75 57.81 5.45
153 INT95696 Gene_expression of Dmd 3 130 0.68 26.02 5.34
154 INT62525 Positive_regulation of SELE 1 38 0.70 46 5.25
155 INT62570 Binding of Pth 2 48 0.48 26.45 4.85
156 INT57274 Positive_regulation of Gene_expression of COL7A1 1 50 0.69 24.19 4.72
157 INT1901 Binding of Mefv 2 24 0.48 32.26 4.5
158 INT4097 Localization of Pth 1 66 0.81 47.17 4.36
159 INT17020 Localization of AHSP 1 11 0.80 3.82 4.34
160 INT67279 Localization of PRTN3 1 11 0.50 14.18 4.3
161 INT21686 Positive_regulation of Gene_expression of ras 1 19 0.42 13.79 4.28
162 INT87780 Gene_expression of Gja1 1 22 0.77 5.84 4.24
163 INT17182 Binding of Cea 2 25 0.48 14.98 4.16
164 INT53040 Binding of Agtr1a 5 22 0.47 7.36 4.15
165 INT44789 Binding of Sdcbp 1 10 0.36 1.65 4.01
166 INT35175 Localization of IL18 1 18 0.80 12.96 3.83
167 INT26282 Negative_regulation of ELN 2 9 0.51 6.37 3.76
168 INT10992 Gene_expression of PARP1 1 32 0.76 22.22 3.74
169 INT104624 Negative_regulation of Apoe 1 26 0.59 19.25 3.71
170 INT91511 Positive_regulation of Localization of CYC1 1 15 0.67 14.68 3.57
171 INT10059 Binding of CSH1 1 17 0.35 5.28 3.37
172 INT87517 Gene_expression of LDLR 1 73 0.69 37.35 3.32
173 INT32340 Negative_regulation of Lnpep 1 14 0.49 2.63 3.26
174 INT61547 Regulation of Fgf2 2 21 0.47 7.23 3.24
175 INT155091 Localization of PARP1 3 15 0.63 13.34 3.15
176 INT92814 Negative_regulation of NOS3 1 25 0.51 20.67 3.07
177 INT77604 Positive_regulation of Binding of VCAM1 1 4 0.47 6.54 3.06
178 INT9130 Negative_regulation of TGFB1 1 16 0.41 12.21 2.92
179 INT31923 Positive_regulation of Positive_regulation of Adra2a 1 7 0.44 1.88 2.89
180 INT77602 Binding of VCAM1 1 8 0.41 8.66 2.86
181 INT28891 Localization of Selp 2 13 0.60 8.23 2.83
182 INT162380 Negative_regulation of CXCR2 1 11 0.57 6.98 2.76
183 INT88852 Protein_catabolism of Casp3 1 28 0.65 23.57 2.74
184 INT81411 Negative_regulation of Sele 1 8 0.38 7 2.7
185 INT215599 Positive_regulation of Positive_regulation of Adora1 2 7 0.47 2.29 2.58
186 INT27835 Regulation of Positive_regulation of Ren 1 10 0.44 2.27 2.38
187 INT74695 Gene_expression of Ace 2 41 0.73 53.33 2.33
188 INT43723 Regulation of Vegfa 1 9 0.34 4.96 2.28
189 INT51869 Negative_regulation of Dmd 1 24 0.52 10.4 2.18
190 INT85085 Positive_regulation of KIT 1 36 0.53 30.08 2.17
191 INT163833 Positive_regulation of Localization of PARP1 1 7 0.28 7.54 2.14
192 INT222230 Positive_regulation of Gene_expression of Cxcl12 1 11 0.59 5.26 2.13
193 INT98176 Positive_regulation of Localization of Casp3 1 7 0.33 6.85 2.12
194 INT138490 Positive_regulation of Il13 1 9 0.36 5.42 2.06
195 INT12005 Negative_regulation of Localization of Agt 1 6 0.57 1.49 2.06
196 INT53036 Binding of Agtr2 3 9 0.33 3.74 1.99
197 INT129168 Binding of Anxa5 1 8 0.41 9.53 1.91
198 INT16205 Localization of ras 1 25 0.73 18.99 1.85
199 INT139459 Negative_regulation of MAX 1 6 0.57 0.32 1.79
200 INT122468 Negative_regulation of Localization of CYC1 1 8 0.57 7.75 1.74
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