J:The Open Neurology Journal

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This page displays the top molecular interactions and top single events that were mentioned in the literature in this journal. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported in this journal. They are ordered first by their pain relevance and then by number of times they were reported in this journal. Text mining (TM) confidence, disease relevance and pain relevance are highlighted in green if they are judged to be high and red if not. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Reported in Journal Documents TM Confidence Disease Relevance Pain Relevance
1 INT251729 Binding of FEN1 and EXOSC1 1 1 0.19 1.13 0.74
2 INT251730 Binding of CD70 and SUGT1 1 1 0.01 0.85 0.49
3 INT251731 Binding of CD70 and SNRNP70 1 1 0.04 0.84 0.49
4 INT270433 PLAT Positive_regulation of Positive_regulation of Gsk3b 1 1 0.04 0.5 0.21
5 INT258812 Sugt1 Positive_regulation of Ace 1 1 0.05 1.26 0.16
6 INT270416 PLAT Negative_regulation of Positive_regulation of PLG 1 1 0.00 0.48 0.15
7 INT270432 Lhb Positive_regulation of APP 1 1 0.03 0.51 0.03
8 INT270431 Gnrh1 Positive_regulation of APP 1 1 0.06 0.51 0.03

Single Events

The table below shows the top 100 pain related interactions that have been reported in this journal. They are ordered first by their pain relevance and then by number of times they were reported in this journal. Text mining (TM) confidence, disease relevance and pain relevance are highlighted in green if they are judged to be high and red if not. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Reported in Journal Documents TM Confidence Disease Relevance Pain Relevance
1 INT2542 Localization of Calca 3 2008 0.81 518.3 1408.65
2 INT1912 Gene_expression of Calca 2 1152 0.78 453.25 739.84
3 INT3439 Localization of Abat 1 1017 0.78 112.39 727.06
4 INT58061 Gene_expression of Trpv1 1 1117 0.78 451.54 637.59
5 INT2543 Positive_regulation of Calca 2 787 0.70 331.13 592.08
6 INT64202 Positive_regulation of Trpv1 1 643 0.70 249.66 397.42
7 INT2540 Negative_regulation of Calca 1 538 0.59 172.11 384.38
8 INT5059 Positive_regulation of TNF 1 1050 0.70 896.51 322.81
9 INT2909 Positive_regulation of Abat 1 334 0.70 62.1 256.43
10 INT9987 Gene_expression of Abat 1 296 0.78 95.46 226.34
11 INT6481 Binding of TNF 4 624 0.48 510.2 214.82
12 INT2211 Negative_regulation of Abat 1 267 0.59 66.51 200.98
13 INT3300 Positive_regulation of Gene_expression of Calca 1 179 0.70 77.76 144.2
14 INT48593 Positive_regulation of NOS1 1 420 0.68 226.15 114.71
15 INT3038 Gene_expression of INS 2 1583 0.78 1174.16 107.01
16 INT52651 Positive_regulation of Prkaca 1 136 0.67 40.82 99.16
17 INT81417 Gene_expression of PAG1 1 94 0.58 90.85 92.79
18 INT1281 Negative_regulation of Maoa 3 203 0.59 22.47 91.66
19 INT77435 Positive_regulation of Nos2 1 343 0.70 208.49 91.43
20 INT74376 Gene_expression of Cnr1 1 173 0.78 73.43 89.7
21 INT19771 Positive_regulation of PAG1 2 69 0.61 75.61 76.88
22 INT62374 Gene_expression of NGF 2 158 0.78 77.87 76.45
23 INT14049 Positive_regulation of GRIN1 2 102 0.70 48.31 71.06
24 INT65733 Positive_regulation of Cnr1 1 125 0.70 40.27 67.33
25 INT67614 Positive_regulation of PPARA 1 438 0.68 293.28 63.61
26 INT5058 Positive_regulation of IFNA1 1 356 0.70 245.75 60.52
27 INT96937 Gene_expression of Mmp9 2 191 0.75 150.3 56.01
28 INT65245 Gene_expression of Nos3 2 121 0.78 98.14 41.56
29 INT12228 Positive_regulation of Gene_expression of Abat 1 44 0.65 17.51 40.55
30 INT48075 Positive_regulation of Il1b 1 71 0.67 48.63 40.48
31 INT169180 Binding of SNRNP70 2 204 0.47 119.1 29.3
32 INT94658 Positive_regulation of F2rl1 1 51 0.70 33.65 27.46
33 INT75418 Negative_regulation of Cnr1 1 41 0.59 14.65 27.28
34 INT2261 Gene_expression of Lhb 1 121 0.77 42.78 26.04
35 INT67610 Positive_regulation of Pparg 2 53 0.70 31.91 25.2
36 INT73670 Gene_expression of Vcam1 2 128 0.78 123.79 24.96
37 INT44954 Gene_expression of APP 1 191 0.78 105.86 23.9
38 INT48536 Positive_regulation of Grm8 1 46 0.61 14.31 23.56
39 INT90849 Gene_expression of F2rl1 1 55 0.78 31.31 20.65
40 INT16794 Binding of App 1 103 0.48 64.87 19.79
41 INT27670 Negative_regulation of Ace 3 122 0.57 79.21 18.08
42 INT23657 Positive_regulation of APP 2 64 0.70 39.76 16.68
43 INT20216 Localization of NGF 1 40 0.80 18.16 16.61
44 INT78749 Gene_expression of SCN10A 3 25 0.75 9.23 16.5
45 INT1020 Negative_regulation of BCHE 1 109 0.59 44.86 16.4
46 INT124371 Negative_regulation of Gsk3b 3 170 0.55 87.92 15.51
47 INT113606 Positive_regulation of Gene_expression of Mmp9 2 46 0.64 44 15.07
48 INT63553 Binding of PAG1 1 14 0.48 12.51 14.76
49 INT124372 Gene_expression of Gsk3b 3 164 0.75 95.64 14.35
50 INT81495 Positive_regulation of CNR2 1 28 0.67 14.62 14.27
51 INT20665 Gene_expression of ACE 1 87 0.78 51.71 14.19
52 INT6365 Localization of Edn1 1 56 0.81 18.84 13.83
53 INT86646 Positive_regulation of SCN10A 34 71 0.69 50.61 13.24
54 INT54763 Binding of Il6 1 82 0.48 63.27 12.89
55 INT8210 Positive_regulation of Gene_expression of INS 2 188 0.68 146.57 12.83
56 INT88365 Regulation of Faah 1 18 0.45 6.63 12.54
57 INT122812 Gene_expression of SNRNP70 3 130 0.75 67 12.5
58 INT73431 Positive_regulation of Nos3 1 82 0.65 53.22 11.61
59 INT116347 Positive_regulation of Positive_regulation of GRIN1 1 12 0.49 3.63 11.44
60 INT73959 Positive_regulation of NOSTRIN 2 49 0.61 31.1 11.27
61 INT173159 Localization of PPARA 1 96 0.74 64.55 10.26
62 INT106565 Negative_regulation of Gene_expression of Cnr1 1 19 0.59 6.98 9.93
63 INT18121 Binding of Maoa 2 20 0.48 2.4 9.3
64 INT135372 Positive_regulation of Gsk3b 2 72 0.70 50.03 9.28
65 INT20664 Binding of ACE 1 60 0.48 35.27 9.16
66 INT73342 Protein_catabolism of Faah 1 19 0.97 5.11 8.99
67 INT12095 Negative_regulation of Edn1 1 26 0.59 12.01 8.79
68 INT81444 Positive_regulation of Gene_expression of Vcam1 1 40 0.70 46.38 8.58
69 INT5359 Protein_catabolism of Abat 1 12 0.62 5.11 8.54
70 INT70572 Gene_expression of Fst 3 33 0.78 5.22 8.24
71 INT60285 Negative_regulation of Racgap1 1 27 0.56 21.71 8.14
72 INT389 Gene_expression of Ace 1 21 0.67 10.31 8.1
73 INT1925 Gene_expression of PLAT 1 47 0.75 34.76 7.88
74 INT172789 Regulation of Gene_expression of Nos3 1 15 0.53 16.23 7.86
75 INT1771 Positive_regulation of Ace 3 31 0.68 10.47 7.46
76 INT800 Negative_regulation of Grhpr 2 21 0.42 10.3 7.17
77 INT10787 Gene_expression of Gnrh1 3 64 0.78 23.06 6.76
78 INT1926 Positive_regulation of PLAT 1 54 0.66 31.42 6.49
79 INT4561 Gene_expression of PLG 1 32 0.75 17.59 6.21
80 INT63042 Binding of Apoe 1 59 0.48 31.23 5.88
81 INT18677 Gene_expression of F3 1 50 0.65 30.86 5.86
82 INT55309 Positive_regulation of Ssr1 3 20 0.46 5.97 5.74
83 INT84909 Positive_regulation of SUGT1 1 22 0.08 22.01 5.43
84 INT105256 Positive_regulation of Gene_expression of F2rl1 1 6 0.68 10.09 4.83
85 INT12104 Positive_regulation of PLG 3 45 0.68 28.94 4.81
86 INT9310 Negative_regulation of Ssr1 2 20 0.49 6.55 4.73
87 INT137795 Positive_regulation of BACE1 1 3 0.68 4.74 4.31
88 INT170738 Binding of Icam1 1 23 0.37 25.49 4.09
89 INT22838 Gene_expression of Fgg 3 26 0.25 19.9 3.88
90 INT28060 Positive_regulation of Hdlcl1 1 48 0.66 37.31 3.79
91 INT52047 Gene_expression of APOE 1 50 0.78 34.75 3.52
92 INT102516 Gene_expression of Map2 2 29 0.69 6.73 3.41
93 INT27171 Localization of Maoa 1 7 0.73 2.32 3.1
94 INT33237 Regulation of Fst 2 10 0.39 1.3 3
95 INT133080 Gene_expression of GATA3 1 15 0.61 5.64 2.89
96 INT264847 Gene_expression of GRM1 1 4 0.34 1.88 2.87
97 INT178772 Transcription of App 1 17 0.70 10.79 2.79
98 INT8652 Protein_catabolism of Ace 1 10 0.94 4.7 2.74
99 INT110980 Gene_expression of CTSB 1 17 0.45 8.02 2.69
100 INT100144 Negative_regulation of Positive_regulation of PPARA 1 17 0.49 12.71 2.68
101 INT50080 Binding of APOE 1 38 0.45 29.61 2.67
102 INT55310 Gene_expression of Ssr1 1 20 0.67 3.47 2.56
103 INT35390 Phosphorylation of Map2 1 12 0.81 2.06 2.47
104 INT145101 Transcription of Nos3 1 8 0.70 6.04 2.47
105 INT251734 Localization of CD70 3 1 0.69 3.93 2.42
106 INT22679 Binding of SERPINE1 1 25 0.36 17.33 2.36
107 INT73809 Regulation of Nos3 1 18 0.45 10.05 2.27
108 INT28739 Binding of Ins1 1 35 0.37 22.43 2.14
109 INT388 Positive_regulation of Gene_expression of Ace 1 4 0.42 1.04 2.13
110 INT285861 Gene_expression of GRM7 3 1 0.02 2.44 2.04
111 INT92129 Positive_regulation of Gene_expression of F3 1 13 0.08 12.13 2.02
112 INT36400 Regulation of SCN10A 1 7 0.62 2.73 1.97
113 INT5358 Positive_regulation of Protein_catabolism of Abat 1 2 0.38 1.28 1.89
114 INT75527 Positive_regulation of Gene_expression of TP53BP2 1 4 0.38 3.3 1.88
115 INT13544 Localization of LTA 1 9 0.78 6.34 1.8
116 INT115737 Regulation of Protein_catabolism of Faah 1 3 0.44 1 1.77
117 INT192684 Negative_regulation of vs 1 15 0.19 9.18 1.75
118 INT173177 Positive_regulation of Localization of PPARA 1 21 0.49 12.61 1.74
119 INT8757 Binding of ACHE 1 10 0.48 5.84 1.72
120 INT113676 Gene_expression of NRP1 1 22 0.72 10.81 1.71
121 INT149944 Positive_regulation of Phosphorylation of Map2 1 7 0.69 1.09 1.68
122 INT66930 Positive_regulation of Tcirg1 1 2 0.15 1.18 1.6
123 INT179550 Phosphorylation of Ywhaq 1 8 0.03 6.24 1.48
124 INT75522 Gene_expression of TP53BP2 2 3 0.52 2.74 1.46
125 INT185724 Regulation of GATA4 1 2 0.45 1.6 1.33
126 INT148562 Positive_regulation of GNAS 1 13 0.16 5.31 1.32
127 INT329032 Gene_expression of Tub 5 1 0.75 0.48 1.21
128 INT219752 Localization of EXOSC1 1 4 0.78 6.92 1.19
129 INT98992 Binding of Vcam1 1 13 0.34 12.97 1.04
130 INT129425 Negative_regulation of Ldlr 2 22 0.42 17.15 0.97
131 INT251744 Binding of GATA4 1 1 0.36 1.55 0.96
132 INT10827 Gene_expression of Apob 2 16 0.78 13.08 0.9
133 INT97768 Positive_regulation of Gene_expression of PLG 1 5 0.49 2.49 0.89
134 INT93899 Negative_regulation of Tcirg1 1 5 0.14 4.34 0.85
135 INT10828 Regulation of Apob 1 7 0.39 7.55 0.83
136 INT285862 Positive_regulation of GRM7 1 1 0.01 0.8 0.82
137 INT118078 Phosphorylation of APP 1 10 0.79 2.5 0.76
138 INT254017 Negative_regulation of Gene_expression of Map2 1 3 0.48 0.93 0.74
139 INT251735 Binding of FEN1 1 1 0.17 1.13 0.74
140 INT134754 Positive_regulation of Gene_expression of PLAT 1 9 0.49 4.75 0.72
141 INT270428 Negative_regulation of Binding of APOE 1 2 0.41 1.16 0.7
142 INT120477 Gene_expression of Sugt1 2 2 0.06 1.07 0.69
143 INT242137 Negative_regulation of Positive_regulation of Gsk3b 1 7 0.39 2.99 0.67
144 INT243481 Gene_expression of GATA2 1 3 0.50 3.34 0.62
145 INT329028 Phosphorylation of Tub 2 1 0.79 0.32 0.6
146 INT191164 Gene_expression of CD70 2 5 0.66 3.01 0.59
147 INT236648 Binding of Hrt1 2 4 0.07 5.07 0.51
148 INT58591 Negative_regulation of Positive_regulation of PLG 1 4 0.42 2.46 0.51
149 INT251745 Gene_expression of GATA1 1 2 0.58 0.96 0.51
150 INT43091 Positive_regulation of Negative_regulation of Ace 1 3 0.30 1.51 0.48
151 INT151903 Positive_regulation of Positive_regulation of PLG 2 3 0.45 1.53 0.48
152 INT145100 Regulation of Transcription of Nos3 1 4 0.44 2.05 0.46
153 INT22837 Regulation of Fgg 1 2 0.10 1.87 0.41
154 INT185722 Positive_regulation of GATA4 1 2 0.50 1.09 0.39
155 INT329031 Positive_regulation of Phosphorylation of Tub 1 1 0.49 0.16 0.38
156 INT208553 Phosphorylation of YWHAQ 1 4 0.80 3.42 0.36
157 INT74233 Binding of Ssr1 1 8 0.41 1.67 0.35
158 INT142491 Positive_regulation of Positive_regulation of SCN10A 3 6 0.61 3.48 0.35
159 INT329030 Positive_regulation of Gene_expression of Map2 1 1 0.57 0.27 0.33
160 INT270418 Negative_regulation of Negative_regulation of Racgap1 1 1 0.02 0.53 0.31
161 INT329029 Regulation of Gene_expression of Tub 2 1 0.44 0.07 0.3
162 INT176895 Negative_regulation of EEF1A2 1 3 0.41 0.85 0.29
163 INT161085 Positive_regulation of Notch3 1 4 0.41 4.36 0.27
164 INT251733 Binding of CD70 1 1 0.27 0.76 0.22
165 INT15255 Negative_regulation of Positive_regulation of PLAT 1 3 0.46 0.87 0.2
166 INT270417 Binding of Ywhaq 1 1 0.00 0.52 0.2
167 INT270426 Regulation of Binding of SERPINE1 1 1 0.06 0.42 0.17
168 INT287448 Gene_expression of Tagln 1 6 0.65 3.73 0.16
169 INT316238 Localization of Tcirg1 1 2 0.30 1.98 0.14
170 INT316240 Regulation of Tcirg1 1 2 0.16 2.05 0.13
171 INT327770 Binding of Tcirg1 1 1 0.14 1.65 0.12
172 INT270427 Negative_regulation of Binding of ACHE 1 2 0.42 1.82 0.11
173 INT270425 Binding of NEGR1 1 1 0.04 0.94 0.09
174 INT287445 Regulation of Tagln 1 2 0.29 2.59 0.08
175 INT329023 Positive_regulation of Cbs 1 1 0.18 1.36 0.07
176 INT251741 Regulation of Gene_expression of SCN10A 2 1 0.45 1.08 0.06
177 INT251742 Regulation of Positive_regulation of SCN10A 3 1 0.27 1.37 0.06
178 INT269274 Regulation of MTNR1A 1 3 0.60 1.47 0.05
179 INT175390 Localization of Ssr1 1 4 0.48 1.05 0.04
180 INT299151 Gene_expression of Ren2 1 3 0.37 1.96 0
181 INT299147 Positive_regulation of Gene_expression of Ren2 1 2 0.24 1.51 0
182 INT251746 Protein_catabolism of Ssr1 1 1 0.26 0.26 0
183 INT329021 Regulation of Gene_expression of Notch3 1 1 0.09 2.04 0
184 INT329022 Gene_expression of Notch3 1 1 0.27 2.04 0
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