J:The Open Orthopaedics Journal

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This page displays the top molecular interactions and top single events that were mentioned in the literature in this journal. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported in this journal. They are ordered first by their pain relevance and then by number of times they were reported in this journal. Text mining (TM) confidence, disease relevance and pain relevance are highlighted in green if they are judged to be high and red if not. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Reported in Journal Documents TM Confidence Disease Relevance Pain Relevance
1 INT284370 Igf1 Regulation of Gene_expression of VEGFA 1 1 0.37 0.05 0
2 INT284366 Gopc Regulation of Vegfa 1 1 0.04 0 0
3 INT284368 ras Regulation of Transcription of VEGFA 1 1 0.14 0.1 0
4 INT284369 Igf1 Regulation of VEGFA 1 1 0.27 0.05 0
5 INT284371 ras Regulation of Gene_expression of VEGFA 1 1 0.06 0.1 0

Single Events

The table below shows the top 100 pain related interactions that have been reported in this journal. They are ordered first by their pain relevance and then by number of times they were reported in this journal. Text mining (TM) confidence, disease relevance and pain relevance are highlighted in green if they are judged to be high and red if not. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Reported in Journal Documents TM Confidence Disease Relevance Pain Relevance
1 INT34869 Negative_regulation of PTGS2 1 778 0.59 366.76 319.85
2 INT68684 Gene_expression of VEGFA 15 2371 0.78 1742.52 259.2
3 INT626 Localization of CALCA 1 289 0.81 125.39 221.15
4 INT95787 Positive_regulation of Mapk1 2 568 0.70 226.51 220.94
5 INT2391 Negative_regulation of PTGS1 1 501 0.59 207.62 205.6
6 INT15515 Positive_regulation of Crp 1 700 0.70 604.24 150.15
7 INT92434 Phosphorylation of Mapk1 1 287 0.82 91.65 83.46
8 INT68682 Positive_regulation of VEGFA 6 640 0.70 454.14 81.65
9 INT79494 Positive_regulation of Gene_expression of VEGFA 2 577 0.70 442.94 69.73
10 INT11491 Positive_regulation of KNG1 1 128 0.67 60.41 58.74
11 INT3361 Positive_regulation of Esr1 1 273 0.69 208.53 44.81
12 INT80124 Negative_regulation of VEGFA 16 450 0.58 311.19 44.53
13 INT92437 Positive_regulation of Phosphorylation of Mapk1 1 113 0.70 32.19 40.29
14 INT102611 Negative_regulation of Positive_regulation of Mapk1 1 74 0.58 35.57 39.37
15 INT9082 Positive_regulation of ESR1 1 238 0.69 148.51 36.69
16 INT101992 Localization of VEGFA 21 413 0.81 258.23 36.15
17 INT70437 Negative_regulation of Mdk 1 115 0.57 41.03 35.72
18 INT114881 Gene_expression of Akt1 1 227 0.78 102.49 31.81
19 INT48693 Regulation of VEGFA 2 268 0.62 191.88 31.52
20 INT99688 Negative_regulation of Gene_expression of VEGFA 4 274 0.58 201.8 31.1
21 INT37296 Binding of Esr1 2 117 0.43 62.51 27.33
22 INT21687 Positive_regulation of ras 1 143 0.58 97.34 27.31
23 INT95788 Positive_regulation of Positive_regulation of Mapk1 1 83 0.69 24.75 25.84
24 INT116282 Gene_expression of Mmp13 1 83 0.75 45.4 20.18
25 INT68683 Regulation of Gene_expression of VEGFA 5 143 0.62 104.19 20.14
26 INT756 Gene_expression of C3 1 138 0.75 100.6 19.2
27 INT5398 Positive_regulation of ALPP 4 178 0.70 110.52 19.18
28 INT4067 Negative_regulation of Esr1 1 97 0.50 43.45 17.52
29 INT68681 Transcription of VEGFA 6 132 0.71 80.47 17.03
30 INT5841 Gene_expression of Vim 2 181 0.72 138.54 16.33
31 INT170855 Negative_regulation of GOPC 1 188 0.38 70.92 15.41
32 INT19963 Gene_expression of COL1A1 1 118 0.59 42.11 15.15
33 INT34590 Gene_expression of ALPP 1 199 0.75 89.85 15.1
34 INT1284 Negative_regulation of Mmp13 1 20 0.57 36.21 14.91
35 INT109535 Gene_expression of Vegfa 3 116 0.75 84.61 14.89
36 INT55740 Gene_expression of Timp1 1 53 0.75 28.63 13.85
37 INT51014 Transcription of IL2 1 42 0.71 21.56 12.7
38 INT28872 Positive_regulation of CSRP1 1 49 0.70 47.23 11.7
39 INT110110 Gene_expression of ACCS 2 85 0.58 75.88 10.2
40 INT102698 Binding of ACCS 4 54 0.42 66.73 9.06
41 INT4991 Positive_regulation of Vim 1 74 0.69 69.84 8.33
42 INT21685 Gene_expression of ras 1 115 0.66 85.6 7.76
43 INT153794 Gene_expression of Ctsk 1 51 0.77 24.99 7.28
44 INT53704 Negative_regulation of Col7a1 1 42 0.35 22.4 6.88
45 INT166707 Protein_catabolism of Col7a1 1 24 0.74 20.47 6.39
46 INT111545 Phosphorylation of VEGFA 1 50 0.76 22.19 5.88
47 INT34592 Positive_regulation of Gene_expression of ALPP 1 51 0.67 20.62 5.68
48 INT13170 Gene_expression of Comp 3 25 0.74 8.68 5.62
49 INT99690 Negative_regulation of Positive_regulation of VEGFA 2 30 0.58 14.56 4.79
50 INT134657 Localization of Akt1 3 37 0.68 11.58 4.62
51 INT103153 Positive_regulation of Transcription of VEGFA 1 34 0.69 22.16 4.22
52 INT156097 Negative_regulation of Localization of VEGFA 14 70 0.58 34.96 4.17
53 INT55741 Negative_regulation of Timp1 1 15 0.51 8.12 4.09
54 INT118835 Positive_regulation of Vegfa 2 18 0.59 11.2 3.91
55 INT137702 Binding of TTN 1 7 0.35 4.48 3.62
56 INT132187 Gene_expression of Ecm1 1 14 0.21 8.12 3.52
57 INT116281 Negative_regulation of Gene_expression of Mmp13 1 15 0.41 9.96 3.41
58 INT137609 Localization of Vegfa 2 22 0.78 14.67 3.01
59 INT83374 Gene_expression of FGF7 1 83 0.78 44.18 2.6
60 INT79261 Positive_regulation of Gene_expression of COL1A1 1 24 0.36 7.49 2.45
61 INT141367 Negative_regulation of Transcription of IL2 1 9 0.32 2.07 2.43
62 INT64797 Regulation of ALPP 1 18 0.24 9.71 2.24
63 INT146660 Negative_regulation of Ctsk 1 9 0.43 6.01 2.07
64 INT192684 Negative_regulation of vs 1 15 0.19 9.18 1.75
65 INT118833 Positive_regulation of Gene_expression of Vegfa 1 11 0.65 8.14 1.7
66 INT108798 Negative_regulation of Positive_regulation of ALPP 2 9 0.25 4.26 1.46
67 INT159102 Regulation of Ecm1 1 9 0.16 1.28 1.41
68 INT109536 Negative_regulation of Vegfa 3 15 0.46 10.35 1.39
69 INT36947 Gene_expression of PNLIP 1 13 0.45 11.04 1.23
70 INT199601 Positive_regulation of FGF7 1 9 0.50 6.13 1.22
71 INT61466 Positive_regulation of Acp5 2 15 0.66 10.17 1.16
72 INT165962 Transcription of Vim 1 3 0.39 1.47 1.01
73 INT284359 Negative_regulation of Mvk 2 4 0.37 6.62 0.99
74 INT25087 Negative_regulation of FEA 1 3 0.37 0.28 0.99
75 INT155042 Gene_expression of SHFM1 1 25 0.65 4.57 0.94
76 INT46483 Localization of Dpep1 1 4 0.06 1.58 0.88
77 INT151907 Binding of Ecm1 2 6 0.11 2.48 0.83
78 INT67038 Positive_regulation of Positive_regulation of ALPP 1 5 0.08 2.61 0.77
79 INT159988 Localization of Ctsk 1 5 0.70 2.9 0.74
80 INT105131 Gene_expression of KRT122P 1 8 0.58 9.1 0.7
81 INT188166 Transcription of ALPP 1 9 0.56 4.34 0.62
82 INT274679 Regulation of Negative_regulation of Mmp13 1 2 0.43 1.78 0.57
83 INT174873 Regulation of Transcription of VEGFA 1 8 0.43 3.71 0.55
84 INT172964 Binding of Vegfa 3 14 0.47 10.62 0.53
85 INT193424 Regulation of Fdps 1 2 0.28 2.18 0.5
86 INT284362 Positive_regulation of Mvk 1 3 0.44 3.32 0.46
87 INT254080 Positive_regulation of SHFM1 2 4 0.34 0.76 0.41
88 INT152023 Regulation of Vegfa 1 4 0.52 3.99 0.41
89 INT75350 Gene_expression of Mgp 3 3 0.77 0.42 0.4
90 INT274681 Positive_regulation of Protein_catabolism of Col7a1 1 2 0.05 1.18 0.28
91 INT274789 Positive_regulation of Gene_expression of PNLIP 1 1 0.03 0.24 0.08
92 INT293883 Positive_regulation of SLA 1 1 0.25 0.34 0.07
93 INT270865 Positive_regulation of Transcription of Vim 1 1 0.21 0.16 0.04
94 INT270859 Positive_regulation of Gene_expression of SHFM1 1 2 0.49 0.79 0.03
95 INT261190 Regulation of Hprt 1 3 0.60 0 0
96 INT284357 Gene_expression of Mvk 1 2 0.38 1.78 0
97 INT268244 Negative_regulation of Localization of Akt1 3 2 0.28 2 0
98 INT284363 Binding of Mvk 1 1 0.03 0 0
99 INT321921 Gene_expression of FEA 1 1 0.34 0.48 0
100 INT284358 Positive_regulation of Cdk20 1 1 0.45 0 0
101 INT284361 Positive_regulation of Gene_expression of Mvk 1 1 0.04 0.12 0
102 INT284360 Negative_regulation of Gene_expression of Mvk 1 1 0.04 0.12 0
103 INT274680 Regulation of Protein_catabolism of Col7a1 1 1 0.05 0.4 0
104 INT284364 Negative_regulation of Positive_regulation of Mvk 1 1 0.04 0.12 0
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