J:Theor Biol Med Model

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This page displays the top molecular interactions and top single events that were mentioned in the literature in this journal. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported in this journal. They are ordered first by their pain relevance and then by number of times they were reported in this journal. Text mining (TM) confidence, disease relevance and pain relevance are highlighted in green if they are judged to be high and red if not. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Reported in Journal Documents TM Confidence Disease Relevance Pain Relevance
1 INT189859 Binding of SLC6A3 and ADHD1 2 1 0.32 0.68 0.48
2 INT193695 Il2 Positive_regulation of Ctla4 1 1 0.01 1.63 0.18
3 INT193693 Binding of Myd88 and Pain1 1 2 0.14 0.82 0.13
4 INT193697 Apaf1 Positive_regulation of CASP9 1 1 0.02 1.84 0.12
5 INT193691 'Positive_regulation of ' Positive_regulation of Bcr 1 1 0.01 0.07 0.08
6 INT193692 IgG2a Positive_regulation of Bcr 1 1 0.02 0.07 0.08
7 INT193694 IgG2a Positive_regulation of Tlr9 1 1 0.05 0.07 0.08
8 INT193696 Binding of CD8A and Trav6-3 1 1 0.00 0.85 0

Single Events

The table below shows the top 100 pain related interactions that have been reported in this journal. They are ordered first by their pain relevance and then by number of times they were reported in this journal. Text mining (TM) confidence, disease relevance and pain relevance are highlighted in green if they are judged to be high and red if not. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Reported in Journal Documents TM Confidence Disease Relevance Pain Relevance
1 INT6483 Gene_expression of TNF 4 3152 0.78 2515.62 929.82
2 INT68684 Gene_expression of VEGFA 1 2371 0.78 1742.52 259.2
3 INT867 Gene_expression of IFNA1 2 930 0.78 594.85 168.03
4 INT55879 Gene_expression of CCL2 1 421 0.78 240.74 166.02
5 INT4768 Positive_regulation of OPRM1 1 212 0.70 31.09 164.28
6 INT5116 Gene_expression of IL2 2 670 0.78 291.13 146.69
7 INT60694 Gene_expression of Il10 1 567 0.78 369.48 143.69
8 INT20374 Gene_expression of Il4 1 515 0.76 306.15 114.12
9 INT60526 Gene_expression of IL10 1 449 0.78 292.71 107.84
10 INT69440 Gene_expression of ROS1 2 752 0.78 477.64 103.83
11 INT90091 Gene_expression of GOPC 3 967 0.67 366.22 103.6
12 INT77435 Positive_regulation of Nos2 1 343 0.70 208.49 91.43
13 INT10534 Positive_regulation of Trib3 1 209 0.60 78.75 81.48
14 INT2289 Gene_expression of PENK 1 203 0.78 55.62 79.49
15 INT56298 Gene_expression of IL4 1 306 0.78 182.18 72.92
16 INT3375 Gene_expression of IGHE 1 535 0.77 387.47 65.46
17 INT11807 Gene_expression of Il2 2 266 0.78 112 64.97
18 INT67981 Positive_regulation of CCL2 5 165 0.70 136.84 61.85
19 INT18981 Gene_expression of ABAT 3 78 0.68 38.35 61.36
20 INT5058 Positive_regulation of IFNA1 1 356 0.70 245.75 60.52
21 INT546 Binding of ALB 1 311 0.48 85.98 60.14
22 INT63975 Positive_regulation of Il10 1 175 0.68 134.13 54.69
23 INT20375 Gene_expression of Hand1 2 213 0.60 148.51 54.53
24 INT15091 Gene_expression of SLC6A4 1 101 0.78 29.91 53.64
25 INT3213 Gene_expression of Ins1 1 511 0.76 357.59 53.32
26 INT19775 Localization of Il1 1 183 0.78 145.5 50.91
27 INT19488 Localization of ABAT 1 56 0.69 21.51 50.56
28 INT4345 Gene_expression of Gtf3a 1 157 0.67 80.75 48.47
29 INT80124 Negative_regulation of VEGFA 1 450 0.58 311.19 44.53
30 INT157666 Positive_regulation of GOPC 1 335 0.60 120.19 42.75
31 INT69437 Positive_regulation of ROS1 4 328 0.58 222.83 40.56
32 INT4862 Localization of PENK 1 62 0.81 11.57 40.28
33 INT3987 Positive_regulation of IGHE 1 316 0.70 283.2 40.16
34 INT77307 Gene_expression of Bcl2 1 399 0.77 319.77 38
35 INT81037 Negative_regulation of Slc6a3 1 70 0.59 15.31 37.01
36 INT101992 Localization of VEGFA 2 413 0.81 258.23 36.15
37 INT74563 Positive_regulation of Gene_expression of ROS1 2 258 0.61 168.18 34.08
38 INT5862 Positive_regulation of Egr1 1 82 0.70 30.4 33.96
39 INT7133 Negative_regulation of MME 2 85 0.59 29.22 33.1
40 INT65698 Localization of CCL2 1 118 0.81 77.54 32.69
41 INT13186 Positive_regulation of Il4 1 113 0.68 71.22 31.4
42 INT91775 Gene_expression of Slc6a4 3 102 0.78 26.45 28.23
43 INT52722 Localization of RETNLB 2 54 0.38 48.63 27.98
44 INT74726 Negative_regulation of Slc6a4 2 61 0.59 21.01 27.84
45 INT14690 Localization of CSF2 2 124 0.80 85.17 27.26
46 INT21900 Gene_expression of Mthfd1 1 150 0.75 69.47 27.03
47 INT17331 Positive_regulation of JUN 1 132 0.69 60.4 27.03
48 INT4877 Gene_expression of MME 1 184 0.78 122.82 24.78
49 INT83797 Gene_expression of Bcl2l1 1 124 0.77 94.55 22.39
50 INT15326 Phosphorylation of Trib3 1 83 0.55 30.96 22.27
51 INT84732 Positive_regulation of Hand2 1 81 0.69 62.07 22
52 INT11157 Binding of EGF 1 88 0.48 53.73 21.25
53 INT110638 Negative_regulation of COMT 1 43 0.59 21.03 21.05
54 INT49774 Binding of DRD2 1 48 0.48 17.42 20.73
55 INT7581 Binding of ADHD1 12 132 0.46 135.1 19.73
56 INT47689 Positive_regulation of Ntrk2 1 44 0.68 16.84 19.59
57 INT11803 Positive_regulation of Il2 2 62 0.70 31.44 18.93
58 INT7056 Positive_regulation of Gene_expression of PENK 1 35 0.70 14.31 18.21
59 INT97984 Negative_regulation of SLC6A4 1 45 0.59 15.43 18.09
60 INT164366 Localization of NLRP1 8 26 0.71 5.9 16.54
61 INT62629 Localization of CNR1 1 35 0.76 11.86 16.3
62 INT9220 Gene_expression of Ighg1 1 125 0.77 85.74 15.92
63 INT60197 Gene_expression of JUN 1 90 0.78 42.32 14.61
64 INT100938 Positive_regulation of Il13 1 47 0.69 42.11 14.36
65 INT99780 Positive_regulation of Cxcl10 2 43 0.69 39.67 13.27
66 INT81629 Positive_regulation of Fas 1 58 0.70 59.63 12.94
67 INT4137 Positive_regulation of C3 1 73 0.69 48.57 12.63
68 INT35467 Gene_expression of DIO2 2 37 0.65 9.56 12.61
69 INT31990 Positive_regulation of SOD1 3 124 0.69 67.79 12.52
70 INT158124 Gene_expression of COL5A2 1 136 0.69 72.3 12.44
71 INT49975 Binding of SLC6A3 1 34 0.47 9.86 12.41
72 INT100096 Regulation of Slc6a4 2 24 0.62 7.25 12.28
73 INT112003 Localization of ROS1 2 94 0.73 66.32 12.16
74 INT145425 Positive_regulation of NLRP1 1 19 0.47 6.93 12.09
75 INT184853 Gene_expression of ADHD1 5 87 0.65 89.2 11.8
76 INT81640 Positive_regulation of Gene_expression of Bcl2 1 106 0.69 84.58 11.63
77 INT37541 Gene_expression of SPP1 1 113 0.77 68.54 11.35
78 INT63773 Gene_expression of DRD2 3 25 0.78 10.41 10.8
79 INT71633 Negative_regulation of SLC6A3 1 25 0.59 10.5 10.69
80 INT149015 Gene_expression of Tph2 1 20 0.78 9.45 10.4
81 INT54473 Binding of ABCB1 1 30 0.48 8.65 10.38
82 INT58449 Binding of Mthfd1 1 47 0.47 22.02 10.29
83 INT7411 Localization of FGFR3 13 40 0.78 4.77 10.24
84 INT10019 Binding of CD8A 1 57 0.36 31.49 10.08
85 INT14881 Gene_expression of Car3 1 49 0.73 14.89 9.94
86 INT3988 Positive_regulation of Gene_expression of IGHE 1 98 0.68 91.46 9.61
87 INT21214 Negative_regulation of Gene_expression of PENK 1 21 0.58 9.14 9.53
88 INT97439 Positive_regulation of Il5 1 46 0.60 25.6 9.47
89 INT3846 Positive_regulation of GSR 1 60 0.50 35.16 9.37
90 INT85651 Positive_regulation of ACACA 1 17 0.67 4.73 8.63
91 INT29121 Positive_regulation of DIO2 4 23 0.67 6.13 8.46
92 INT18583 Positive_regulation of Gene_expression of Ins1 1 67 0.50 49.72 8.26
93 INT61585 Gene_expression of NALCN 3 25 0.52 6.52 8.18
94 INT193663 Binding of Pain1 1 9 0.36 8.84 8.04
95 INT1925 Gene_expression of PLAT 2 47 0.75 34.76 7.88
96 INT25585 Positive_regulation of DNAH8 1 39 0.70 17.96 7.85
97 INT18190 Regulation of DRD2 3 11 0.60 9.01 7.63
98 INT119651 Binding of Slc6a4 1 12 0.32 4.65 7.07
99 INT154115 Positive_regulation of Localization of PENK 1 5 0.49 3.15 6.93
100 INT99942 Positive_regulation of Fasl 1 37 0.68 32.61 6.92
101 INT95117 Gene_expression of PDGFA 1 71 0.71 51.17 6.9
102 INT29794 Regulation of DIO2 4 13 0.44 5.02 6.84
103 INT160562 Localization of Cd4 1 49 0.71 27.58 6.78
104 INT120895 Binding of CCL2 1 22 0.37 15.86 6.55
105 INT90461 Negative_regulation of DRD2 2 21 0.53 8.35 6.55
106 INT157932 Positive_regulation of ADHD1 3 46 0.48 52.18 6.13
107 INT17641 Gene_expression of NLRP1 1 33 0.73 8.85 6.02
108 INT103880 Positive_regulation of DRD2 1 9 0.67 5.57 5.93
109 INT53196 Binding of Cd4 2 44 0.47 27.28 5.85
110 INT84704 Positive_regulation of Nqo1 1 18 0.70 18.64 5.65
111 INT95048 Negative_regulation of ADHD1 3 61 0.51 56.01 5.62
112 INT174851 Positive_regulation of COL5A2 1 46 0.54 12.73 5.48
113 INT28088 Binding of Alb 1 34 0.47 11.06 5.48
114 INT59891 Positive_regulation of GSTK1 2 46 0.67 17.66 5.33
115 INT10171 Binding of Gtf3a 1 33 0.36 19.84 5.1
116 INT68244 Positive_regulation of Ighg1 1 60 0.61 48.86 5.01
117 INT57368 Regulation of ADHD1 2 39 0.50 42.23 5.01
118 INT122675 Negative_regulation of Gene_expression of Slc6a4 1 14 0.59 6.4 4.69
119 INT84911 Gene_expression of SUGT1 1 43 0.11 19.85 4.54
120 INT71716 Binding of Hbegf 1 21 0.28 6.54 4.51
121 INT36309 Negative_regulation of DIO2 2 18 0.57 6.42 4.51
122 INT188672 Positive_regulation of Tlr9 2 15 0.67 13.1 4.48
123 INT71676 Transcription of DRD2 1 5 0.69 1.19 4.47
124 INT83794 Positive_regulation of Gene_expression of Bcl2l1 1 26 0.69 16.89 4.28
125 INT138698 Gene_expression of Txn1 1 15 0.77 11.71 4.24
126 INT57645 Gene_expression of GSTK1 3 54 0.62 21.05 4.2
127 INT156097 Negative_regulation of Localization of VEGFA 1 70 0.58 34.96 4.17
128 INT126659 Gene_expression of Tph1 2 22 0.78 2.04 4.04
129 INT119053 Positive_regulation of SLC6A3 1 15 0.65 2.51 4
130 INT105975 Gene_expression of ACACA 2 16 0.75 5.73 3.86
131 INT68695 Gene_expression of HTT 1 63 0.77 44.54 3.69
132 INT2936 Gene_expression of AGL 1 36 0.49 9.55 3.63
133 INT125622 Regulation of NLRP1 1 7 0.44 1.84 3.62
134 INT14947 Localization of SPARCL1 7 7 0.46 11.97 3.6
135 INT66960 Negative_regulation of ACACA 1 4 0.57 1.21 3.59
136 INT89966 Negative_regulation of Fas 1 26 0.58 24.83 3.5
137 INT224234 Gene_expression of GPR17 3 33 0.65 4.25 3.45
138 INT15299 Gene_expression of IL1RL1 13 37 0.69 10.09 3.43
139 INT130295 Gene_expression of Abcg2 1 21 0.75 9.75 3.42
140 INT7408 Negative_regulation of FGFR3 4 12 0.43 2.38 3.33
141 INT22375 Localization of PDGFA 1 21 0.75 15.46 3.25
142 INT102451 Localization of CALCRL 1 9 0.69 0 3.25
143 INT81453 Positive_regulation of Gene_expression of JUN 1 18 0.50 9.39 3.23
144 INT157401 Gene_expression of Ctla4 1 21 0.65 15.43 3.2
145 INT140555 Positive_regulation of Localization of ROS1 2 29 0.55 23.82 3.14
146 INT93936 Gene_expression of Pgp 1 10 0.59 3.43 3.04
147 INT7409 Negative_regulation of Localization of FGFR3 7 12 0.37 2.24 2.92
148 INT45014 Regulation of IL1RL1 3 12 0.14 1.87 2.67
149 INT189863 Gene_expression of DRD4 4 11 0.68 7.65 2.66
150 INT257950 Regulation of Localization of NLRP1 1 3 0.08 0.27 2.6
151 INT35407 Positive_regulation of C2 1 25 0.69 7.74 2.59
152 INT248419 Negative_regulation of Tph2 2 11 0.59 6.32 2.59
153 INT40315 Gene_expression of Abcc1 2 10 0.76 5.66 2.53
154 INT87360 Binding of ABCC1 1 6 0.47 1.71 2.38
155 INT7410 Positive_regulation of Localization of FGFR3 5 9 0.45 1.97 2.36
156 INT120726 Positive_regulation of Gene_expression of Slc6a4 1 4 0.68 0.51 2.34
157 INT229110 Positive_regulation of Positive_regulation of DIO2 1 3 0.26 1.08 2.31
158 INT133766 Negative_regulation of Fasl 1 11 0.56 11.28 2.27
159 INT101641 Gene_expression of Mcl1 1 25 0.54 20.3 2.23
160 INT158123 Negative_regulation of Gene_expression of COL5A2 1 19 0.46 15.27 2.23
161 INT127386 Positive_regulation of Elk1 2 8 0.42 3.63 2.15
162 INT75939 Positive_regulation of SPARCL1 2 6 0.28 8.74 2.11
163 INT78429 Positive_regulation of TRGC1 1 11 0.44 4.6 2.1
164 INT8785 Gene_expression of ALDH7A1 3 16 0.75 5.55 1.92
165 INT188678 Binding of Tlr7 1 14 0.32 6.6 1.89
166 INT56925 Negative_regulation of TSC1 2 54 0.52 63.39 1.87
167 INT184852 Positive_regulation of Gene_expression of ADHD1 1 6 0.40 5.06 1.66
168 INT61913 Binding of IgG2a 1 10 0.47 5.04 1.64
169 INT216666 Positive_regulation of Localization of NLRP1 2 2 0.09 0.5 1.49
170 INT180249 Negative_regulation of GLUL 2 5 0.15 0.69 1.46
171 INT104250 Positive_regulation of Gene_expression of SPP1 1 17 0.69 13.22 1.44
172 INT109012 Binding of Bas 1 3 0.30 2 1.31
173 INT95116 Negative_regulation of PDGFA 1 24 0.57 19.56 1.29
174 INT14946 Binding of SPARCL1 2 5 0.31 6.57 1.29
175 INT124126 Regulation of Bas 1 3 0.23 1.68 1.29
176 INT113864 Binding of ABCC2 1 5 0.36 0.38 1.25
177 INT257952 Positive_regulation of CUBN 2 1 0.07 0.61 1.22
178 INT185943 Gene_expression of C8A 1 3 0.06 3.14 1.16
179 INT60542 Positive_regulation of Gene_expression of GSTK1 2 11 0.39 6.21 1.13
180 INT210392 Regulation of PDGFA 2 10 0.36 11.41 1.12
181 INT28493 Positive_regulation of IL1RL1 1 10 0.47 3.44 1.11
182 INT36451 Gene_expression of G6PD 1 26 0.75 7.2 1.09
183 INT19628 Regulation of Xdh 1 6 0.45 1.9 1.07
184 INT116362 Positive_regulation of C4A 1 17 0.69 11.53 1.03
185 INT140497 Positive_regulation of NALCN 1 4 0.31 1.03 1
186 INT130297 Positive_regulation of Gene_expression of Abcc1 1 3 0.56 1.06 0.97
187 INT135260 Negative_regulation of Pgp 1 4 0.42 1.13 0.95
188 INT193666 Gene_expression of Gpr83 1 2 0.14 0.92 0.91
189 INT112694 Negative_regulation of Positive_regulation of Fas 1 5 0.42 4.3 0.89
190 INT7552 Negative_regulation of IL1RL1 8 12 0.42 1.68 0.87
191 INT332756 Localization of TREX1 2 1 0.01 0 0.81
192 INT112386 Positive_regulation of Gene_expression of IL1RL1 1 4 0.47 2.72 0.77
193 INT211315 Binding of FGFR3 5 7 0.35 0.97 0.75
194 INT149014 Negative_regulation of Tph1 1 5 0.58 1.43 0.74
195 INT133323 Positive_regulation of Mod2 1 8 0.13 5.55 0.72
196 INT34599 Binding of TST 2 7 0.32 3.88 0.71
197 INT257951 Localization of CUBN 1 1 0.07 0 0.71
198 INT257948 Binding of CUBN 1 1 0.05 0 0.7
199 INT164916 Binding of IL1RL1 1 9 0.33 1.84 0.66
200 INT5262 Positive_regulation of AGL 1 14 0.40 7.51 0.65
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