J:Therapeutics and Clinical Risk Management

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This page displays the top molecular interactions and top single events that were mentioned in the literature in this journal. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported in this journal. They are ordered first by their pain relevance and then by number of times they were reported in this journal. Text mining (TM) confidence, disease relevance and pain relevance are highlighted in green if they are judged to be high and red if not. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Reported in Journal Documents TM Confidence Disease Relevance Pain Relevance
1 INT149117 Binding of CD80 and CTLA4 31 1 0.52 12.7 7.73
2 INT26824 Crh Positive_regulation of Localization of Penk 7 1 0.54 0.42 6.49
3 INT155484 Binding of CD86 and CTLA4 15 1 0.52 8.85 6.09
4 INT101942 Binding of CD40 and CD40LG 16 1 0.23 15.24 4.01
5 INT127128 Binding of CNR1 and CNR2 8 2 0.39 3.98 3.97
6 INT121651 Binding of CXCL12 and CXCR4 13 1 0.48 17.61 3.52
7 INT85743 Pdyn Positive_regulation of Oprk1 3 1 0.32 2.12 3.52
8 INT275850 Binding of NDUFAB1 and SNCA 1 2 0.00 3.78 3.16
9 INT114134 Penk Positive_regulation of Oprm1 2 1 0.24 1.48 2.68
10 INT115367 Binding of IL6 and IL6R 12 5 0.07 8.16 2.36
11 INT148704 Binding of TNF and TNFRSF1A 5 2 0.44 3.3 2.09
12 INT199486 Oprm1 Regulation of Gene_expression of Oprd1 1 1 0.02 0.49 1.84
13 INT275851 PES1 Negative_regulation of CP 1 1 0.01 1.96 1.83
14 INT199287 TNF Positive_regulation of Transcription of Oprm1 2 2 0.02 1.86 1.8
15 INT199503 ENG Positive_regulation of Oprk1 1 1 0.01 0.87 1.69
16 INT199504 ENG Positive_regulation of Oprm1 1 1 0.01 0.87 1.68
17 INT199497 Pdyn Negative_regulation of Il1 1 1 0.00 0.14 1.67
18 INT199490 Penk Positive_regulation of Oprk1 1 1 0.03 0.87 1.64
19 INT199501 Pdyn Positive_regulation of Oprm1 1 1 0.01 0.86 1.63
20 INT306745 Binding of Il12a and IL23A 1 5 0.10 3.25 1.56
21 INT241750 Binding of CD4 and ITIH4 14 5 0.18 5.72 1.53
22 INT199494 Crh Positive_regulation of Localization of Pdyn 1 1 0.02 0.43 1.4
23 INT15846 Crh Positive_regulation of Localization of ENG 3 1 0.07 0.42 1.38
24 INT218309 Binding of CRP and IL6 3 1 0.23 4.78 1.36
25 INT131185 PTH Positive_regulation of Gene_expression of IGF1 3 1 0.44 3.31 1.31
26 INT70226 Binding of TAC1 and B3GAT1 4 2 0.24 4.5 1.26
27 INT199593 Binding of TRPV1 and Myoz1 1 2 0.10 1.7 1.23
28 INT199493 Ngf Regulation of Oprd1 1 1 0.05 1.05 1.15
29 INT119108 Binding of LTBR and TNF 2 1 0.15 1.47 1.07
30 INT206074 Binding of IL6 and IL6ST 7 3 0.32 3.79 1.01
31 INT232426 HRH2 Regulation of Localization of PRL 1 1 0.15 0.38 0.94
32 INT211128 Binding of P4HB and TNF 1 1 0.09 0.97 0.9
33 INT211129 Negative_regulation of Binding of P4HB and TNF 1 1 0.10 0.97 0.9
34 INT232417 Binding of Mtx1 and Ifx 1 2 0.04 0.99 0.86
35 INT199499 Il6 Positive_regulation of Transcription of Oprm1 1 1 0.01 0.8 0.86
36 INT199492 Il6 Positive_regulation of Transcription of Oprm1 1 1 0.01 0.81 0.86
37 INT199487 Il6 Positive_regulation of Oprm1 1 1 0.01 0.8 0.86
38 INT199491 Il6 Positive_regulation of Positive_regulation of Il6 1 1 0.00 0.81 0.86
39 INT199500 Il6 Positive_regulation of Oprm1 1 1 0.01 0.8 0.85
40 INT199495 Il4 Positive_regulation of Positive_regulation of Oprm1 1 1 0.00 0.98 0.78
41 INT199476 Il4 Positive_regulation of Transcription of Stat6 1 1 0.01 0.97 0.77
42 INT211127 Regulation of Binding of MTX1 and TNF 1 1 0.22 0.71 0.74
43 INT123229 OXTR Regulation of Localization of PRL 2 1 0.30 0 0.73
44 INT211130 Binding of MTX1 and TNF 1 1 0.18 0.7 0.73
45 INT199488 Il4 Positive_regulation of Transcription of Oprm1 1 1 0.01 0.84 0.73
46 INT199489 Stat6 Positive_regulation of Oprm1 1 1 0.02 0.85 0.68
47 INT220148 Binding of IGF1 and IGFBP3 12 2 0.36 5.56 0.66
48 INT211105 Binding of CRS and IGHE 1 2 0.02 3.63 0.66
49 INT339794 Sstr2 Positive_regulation of Gene_expression of Sstr5 1 1 0.08 0.25 0.64
50 INT89902 SST Positive_regulation of Localization of PRL 2 1 0.40 0 0.61
51 INT232424 VIP Positive_regulation of Localization of PRL 1 1 0.36 0 0.53
52 INT299785 CTLA4 Negative_regulation of Binding of CD28 2 1 0.17 1.8 0.5
53 INT306732 Il17a Positive_regulation of Gene_expression of Il2 1 1 0.09 1.07 0.46
54 INT306731 Il22 Positive_regulation of Gene_expression of Il2 1 1 0.12 1.07 0.46
55 INT232427 ABAT Regulation of PRL 1 1 0.08 0.26 0.45
56 INT241853 Binding of SLC40A1 and HAMP 3 2 0.41 5.35 0.43
57 INT275849 PES1 Positive_regulation of Gene_expression of TNFAIP1 1 1 0.01 1.28 0.42
58 INT211115 Positive_regulation of Binding of LTBR and TNF 1 1 0.01 0.31 0.39
59 INT181862 Binding of MPO and PRTN3 2 1 0.16 1.18 0.38
60 INT232422 VIP Regulation of Gene_expression of PRL 1 1 0.40 0 0.37
61 INT232421 Binding of PRL and Positive_regulation of Regulation of ABAT 1 1 0.09 0 0.37
62 INT241780 Binding of AVP and TRGV9 1 4 0.12 2.41 0.35
63 INT232419 ABAT Positive_regulation of Localization of PRL 1 1 0.09 0 0.33
64 INT232425 Binding of ABAT and Positive_regulation of PRL 1 1 0.09 0.15 0.33
65 INT318299 Binding of F2 and PRTN3 1 2 0.01 1.92 0.33
66 INT232420 PRL Positive_regulation of Regulation of ABAT 1 1 0.09 0 0.33
67 INT241776 Binding of AVP and Positive_regulation of ADCY1 1 1 0.06 0.54 0.32
68 INT280008 Binding of IFNA1 and PAEP 2 1 0.08 1.29 0.25
69 INT258521 EGFR Positive_regulation of MMP2 1 1 0.39 0.91 0.24
70 INT258398 Binding of IL6R and JAK1 1 1 0.01 0.75 0.23
71 INT308084 Binding of HSPG2 and OXT 1 1 0.04 0.25 0.23
72 INT258565 EGFR Positive_regulation of Meta 1 1 0.39 0.89 0.23
73 INT255044 GLP1R Positive_regulation of Localization of INS 3 1 0.49 1.47 0.22
74 INT241822 Binding of CD4 and HIVEP1 3 2 0.01 2.73 0.21
75 INT318303 Negative_regulation of Myoz1 Negative_regulation of Transcription of IL2 1 1 0.00 0.75 0.21
76 INT306714 IL23A Positive_regulation of TNF 1 1 0.29 0.5 0.21
77 INT241451 Mag Positive_regulation of Ngfr 1 1 0.09 0.1 0.21
78 INT258456 PYCARD Negative_regulation of Localization of Tms 1 1 0.02 0.05 0.21
79 INT258455 Tms Negative_regulation of Localization of PYCARD 1 1 0.02 0.05 0.21
80 INT306746 Il12a Positive_regulation of TNF 1 1 0.24 0.5 0.21
81 INT182634 Binding of CCR5 and MIP 2 1 0.39 1.29 0.2
82 INT306744 IL23A Positive_regulation of Il12a 1 1 0.13 0.59 0.2
83 INT318298 MECOM Negative_regulation of Binding of CD28 1 1 0.00 1.08 0.18
84 INT280052 Negative_regulation of Dpp4 Positive_regulation of Zglp1 1 1 0.03 0.72 0.18
85 INT274386 Binding of CD4 and ERVW-1 1 2 0.05 3.07 0.18
86 INT258399 Binding of IL6R and IL6ST 1 1 0.06 0.61 0.18
87 INT232386 Binding of CD22 and SYCP3 1 1 0.37 0.86 0.16
88 INT306747 IL23A Positive_regulation of Il17a 1 1 0.05 0.51 0.16
89 INT73076 IGF1 Positive_regulation of GH1 4 1 0.45 0.99 0.15
90 INT241462 Binding of OMG and Ngfr 1 1 0.11 0.15 0.15
91 INT318305 Binding of NOD2 and NLRP3 1 2 0.08 1.76 0.15
92 INT241844 Positive_regulation of GNRH1 Positive_regulation of Localization of PLOD1 1 1 0.13 0.08 0.15
93 INT241457 Binding of Mag and Ngfr 1 1 0.09 0.15 0.15
94 INT318306 Binding of DPEP1 and NLRP3 1 2 0.03 1.77 0.15
95 INT241453 Binding of Ngfr and Rtn4r 1 1 0.03 0.15 0.15
96 INT241772 AVP Positive_regulation of ADCY1 1 1 0.09 1.08 0.15
97 INT273561 Binding of CYP1A1 and CYP3A4 1 1 0.02 0.12 0.15
98 INT232174 GAN Positive_regulation of ODT 1 1 0.01 0.98 0.14
99 INT241465 Binding of OMG and Rtn4r 1 1 0.04 0.15 0.14
100 INT241458 Binding of Mag and Rtn4r 1 1 0.03 0.15 0.14
101 INT241454 Rgnef Positive_regulation of Positive_regulation of Rhoa 1 2 0.04 0.11 0.13
102 INT241777 Negative_regulation of Binding of AVP and TRGV9 1 1 0.10 0.75 0.13
103 INT241446 Rgnef Positive_regulation of Rhoa 1 2 0.04 0.1 0.12
104 INT207551 IGF1 Positive_regulation of Gene_expression of GH1 2 1 0.22 1.18 0.11
105 INT241748 CCR5 Regulation of CD4 1 1 0.21 0.39 0.11
106 INT273063 Negative_regulation of Fas Negative_regulation of Positive_regulation of Bcl2 1 1 0.01 0.72 0.11
107 INT258527 Binding of BRAF and RET 1 1 0.21 1.49 0.11
108 INT199583 HIF1A Positive_regulation of Gene_expression of Vhl 1 1 0.26 1.39 0.11
109 INT199595 FGF7 Positive_regulation of Transcription of TNF 1 1 0.40 0.58 0.11
110 INT186240 Binding of AGRP and SCN5A 2 3 0.13 1.19 0.1
111 INT220149 Binding of IGF1 and IGFALS 2 1 0.39 0.44 0.1
112 INT258517 Negative_regulation of CPOX Negative_regulation of Binding of PTGIR 1 1 0.04 0.33 0.1
113 INT232653 Binding of CD2 and MLL 1 1 0.02 0.27 0.1
114 INT258522 Binding of DDR1 and RET 1 1 0.03 1.05 0.1
115 INT280053 Negative_regulation of Dpp4 Negative_regulation of Protein_catabolism of Zglp1 1 1 0.02 0.71 0.1
116 INT199436 Binding of Capns1 and Cysltr1 1 1 0.00 0.79 0.1
117 INT249117 Binding of Abl1 and Bcr 4 1 0.36 2.22 0.09
118 INT228333 Binding of IFNA1 and IRF9 2 1 0.04 0.53 0.09
119 INT232652 Binding of CD2 and ITGAL 1 1 0.03 0.28 0.09
120 INT241774 Binding of AVPR1A and TRGV9 1 1 0.02 0.48 0.09
121 INT199594 FGF7 Positive_regulation of NFE2L2 1 1 0.01 0.52 0.09
122 INT147774 Binding of HLA-B and ABCB6 2 1 0.40 1.03 0.08
123 INT199604 Binding of FGF7 and Fgf1 1 1 0.03 0.21 0.08
124 INT280004 Binding of IFNA1 and CDIPT 1 1 0.01 0.74 0.08
125 INT199603 Positive_regulation of Binding of FGF7 and Fgf1 1 1 0.04 0.21 0.08
126 INT280007 Binding of CLTC and PAEP 1 1 0.06 0.8 0.08
127 INT300246 Binding of ABCB6 and HSR 1 2 0.11 1.86 0.08
128 INT273520 NBN Positive_regulation of CDIPT 1 1 0.06 0.82 0.08
129 INT261262 AIS Negative_regulation of Cyp19a1 1 1 0.01 0.2 0.08
130 INT280005 Binding of PAEP and CDIPT 1 1 0.01 0.74 0.08
131 INT241444 Binding of Tnfrsf19 and Lingo1 1 1 0.08 0.49 0.06
132 INT241447 Binding of Tnfrsf19 and Rtn4r 1 1 0.04 0.49 0.06
133 INT241461 Binding of TNF and Tnfrsf19 1 1 0.17 0.49 0.06
134 INT339779 IGF1 Regulation of GHRH 1 1 0.08 0.38 0.05
135 INT339778 Binding of EDNRA and PTH 1 1 0.12 0.35 0.05
136 INT280057 Zglp1 Positive_regulation of Transcription of INS 1 1 0.04 0.52 0.05
137 INT233303 Binding of CD4 and SRY 1 1 0.07 0.34 0.05
138 INT241751 Negative_regulation of Binding of CD4 and ITIH4 3 1 0.18 1.07 0.04
139 INT241536 Binding of Abcb1b and Abcg2 1 1 0.10 0.17 0.04
140 INT241752 ITIH4 Negative_regulation of Binding of CXCR4 1 1 0.08 0.71 0.04
141 INT241749 ITIH4 Negative_regulation of Binding of CCR5 1 1 0.16 0.71 0.04
142 INT199406 Binding of CYP3A4 and PPIB 1 1 0.40 0 0.04
143 INT241449 Mag Positive_regulation of Protein_catabolism of Ngfr 1 1 0.09 0 0.03
144 INT199526 Ceacam1 Negative_regulation of Col1a1 1 1 0.01 0.06 0.03
145 INT211191 CD28 Positive_regulation of Gene_expression of IL2 1 1 0.15 0.15 0.03
146 INT241460 Rock1 Positive_regulation of Phosphorylation of MLC1 1 1 0.38 0.63 0.03
147 INT241450 Binding of Rhoa and Dpysl3 1 1 0.02 0 0.03
148 INT241459 Gart Positive_regulation of Racgap1 1 1 0.01 0 0.03
149 INT273519 NBN Negative_regulation of YOD1 1 1 0.03 0.56 0.03
150 INT199527 Ceacam1 Negative_regulation of CYP27A1 1 1 0.02 0.06 0.03
151 INT241464 Binding of TNF and Lingo1 1 1 0.13 0.43 0.03
152 INT274384 AGRP Negative_regulation of HIVEP1 1 1 0.00 0.77 0.03
153 INT241463 Binding of TNF and Rtn4r 1 1 0.06 0.43 0.03
154 INT258529 Binding of JAG1 and NOTCH1 3 2 0.06 2.44 0
155 INT258524 IPMK Negative_regulation of KDR 2 1 0.00 1.98 0
156 INT258528 Binding of NOTCH1 and DLL1 2 1 0.07 1.6 0
157 INT258525 IPMK Negative_regulation of DDR1 2 1 0.00 1.97 0
158 INT289293 Binding of CD59 and Cd33 1 1 0.02 1.06 0
159 INT241775 AVP Positive_regulation of Gene_expression of AQP2 1 1 0.08 0.17 0
160 INT241456 Tgtp1 Positive_regulation of Rock1 1 1 0.01 0 0
161 INT241448 Binding of Rock1 and Tgtp1 1 1 0.01 0 0
162 INT241588 Binding of FAS and Fas 1 2 0.05 2.34 0
163 INT294894 CYP3A4 Negative_regulation of CYP2C19 1 1 0.08 0.13 0
164 INT278495 IGFBP2 Positive_regulation of Gene_expression of IGF1 1 1 0.20 0 0
165 INT300244 Binding of HLA-B and HSR 1 1 0.08 0.95 0
166 INT199581 Braf Negative_regulation of Phosphorylation of tk 1 2 0.05 0.6 0
167 INT241500 Binding of Kit and Kitl 1 1 0.08 0.92 0
168 INT273482 Binding of CYSLTR1 and USE1 1 1 0.00 0.77 0
169 INT241852 Binding of EPO and EPCAM 1 1 0.06 0.84 0
170 INT289301 Binding of CD59 and Cd24a 1 1 0.02 1.06 0
171 INT241779 AVP Positive_regulation of TRGV9 1 1 0.17 0.48 0
172 INT278498 IGFBP3 Regulation of GH1 1 1 0.06 0 0
173 INT241769 AVP Regulation of Binding of AVPR1A 1 1 0.11 0.49 0
174 INT241771 Binding of AVP and AVPR1B 1 1 0.04 0.49 0
175 INT280006 Binding of CLTC and IFNA1 1 2 0.04 1.59 0
176 INT199576 Raf1 Negative_regulation of Akt1 1 1 0.00 0.79 0
177 INT241793 NBL1 Negative_regulation of B4GALNT1 1 1 0.00 0.83 0
178 INT233304 Binding of SRY and SLC22A8 1 1 0.34 0.93 0
179 INT258523 Positive_regulation of RAF1 Positive_regulation of Phosphorylation of GSK 1 1 0.19 0.64 0
180 INT294895 CYP3A4 Negative_regulation of CYP2C9 1 1 0.09 0.13 0
181 INT322931 Binding of MOCS1 and Litaf 1 1 0.00 0.82 0
182 INT199580 Braf Negative_regulation of Phosphorylation of Mdk 1 2 0.11 0.6 0
183 INT289296 Binding of CD59 and C6 1 1 0.02 0.5 0
184 INT241778 AVP Positive_regulation of AVPR1A 1 1 0.10 1.32 0
185 INT241443 Binding of Tgtp1 and Cacna1d 1 1 0.00 0 0
186 INT273518 Binding of ALB and NBN 1 1 0.06 0.47 0
187 INT273480 Binding of EPO and RNASEL 1 1 0.08 0.77 0
188 INT199577 Tnk1 Negative_regulation of Akt1 1 1 0.00 0.79 0
189 INT313572 GLP1R Negative_regulation of GCG 1 1 0.29 0.54 0
190 INT336179 Binding of CACNA1F and DLST 1 1 0.01 1.6 0
191 INT211067 Pth Regulation of DMD 1 1 0.01 0.12 0
192 INT199582 Braf Negative_regulation of Akt1 1 1 0.00 0.79 0
193 INT232364 Bgn Negative_regulation of Agxt 1 1 0.02 0.65 0
194 INT274385 Binding of ABAT and CDIPT 1 1 0.00 1.21 0
195 INT199579 Tnk1 Negative_regulation of Raf1 1 1 0.01 0.78 0
196 INT289295 Binding of CD59 and Fcgr3 1 1 0.01 1.06 0
197 INT289297 Negative_regulation of Binding of CD59 and C6 1 1 0.02 0.51 0
198 INT289300 Binding of CD59 and Fut4 1 1 0.01 1.06 0
199 INT274387 Binding of POLA1 and IGSF9 1 1 0.01 0.58 0
200 INT232384 Binding of BCR and C6orf25 1 1 0.00 0.91 0

Single Events

The table below shows the top 100 pain related interactions that have been reported in this journal. They are ordered first by their pain relevance and then by number of times they were reported in this journal. Text mining (TM) confidence, disease relevance and pain relevance are highlighted in green if they are judged to be high and red if not. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Reported in Journal Documents TM Confidence Disease Relevance Pain Relevance
1 INT796 Gene_expression of Penk 2 1902 0.78 275.47 1057.59
2 INT6483 Gene_expression of TNF 44 3152 0.78 2515.62 929.82
3 INT1912 Gene_expression of Calca 1 1152 0.78 453.25 739.84
4 INT292 Localization of Penk 2 876 0.81 88.44 669.14
5 INT728 Positive_regulation of Penk 1 1068 0.70 186.9 636.87
6 INT155 Positive_regulation of Prl 1 1233 0.70 317.93 457.82
7 INT443 Localization of POMC 2 1020 0.81 284.52 443.17
8 INT9238 Gene_expression of IL6 13 1575 0.78 1135.66 424.22
9 INT5895 Gene_expression of Oprm1 15 525 0.78 120.67 407.29
10 INT5660 Binding of Oprd1 2 477 0.48 71.86 342.06
11 INT16260 Gene_expression of Bdnf 1 671 0.78 283.44 339.1
12 INT5235 Negative_regulation of TNF 41 924 0.59 772.91 331.98
13 INT5059 Positive_regulation of TNF 7 1050 0.70 896.51 322.81
14 INT5979 Gene_expression of Oprd1 19 428 0.78 75.64 320.32
15 INT34869 Negative_regulation of PTGS2 2 778 0.59 366.76 319.85
16 INT5540 Positive_regulation of Oprm1 8 344 0.70 76.77 319.71
17 INT4941 Positive_regulation of Oprd1 8 345 0.70 74.26 304.41
18 INT11624 Gene_expression of OPRM1 1 445 0.78 72.36 294.36
19 INT9381 Positive_regulation of TRPV1 1 523 0.70 187.4 276.05
20 INT49750 Negative_regulation of CPOX 65 735 0.58 360.06 274.19
21 INT6852 Localization of TNF 4 883 0.81 705.95 270.84
22 INT10832 Gene_expression of IL8 4 1050 0.78 698.72 270
23 INT9659 Gene_expression of Il6 4 991 0.78 715.11 265.57
24 INT5972 Gene_expression of IL1B 3 948 0.78 510.91 263.97
25 INT68684 Gene_expression of VEGFA 13 2371 0.78 1742.52 259.2
26 INT1893 Localization of Gh 7 1041 0.79 340.23 256.58
27 INT5501 Regulation of Oprd1 2 283 0.62 55.1 249.9
28 INT1562 Localization of Crh 4 499 0.81 126.74 236.68
29 INT626 Localization of CALCA 3 289 0.81 125.39 221.15
30 INT95787 Positive_regulation of Mapk1 3 568 0.70 226.51 220.94
31 INT6665 Gene_expression of FOS 1 520 0.77 165.31 217.66
32 INT6481 Binding of TNF 20 624 0.48 510.2 214.82
33 INT6482 Positive_regulation of Gene_expression of TNF 6 659 0.70 569.88 210
34 INT16259 Positive_regulation of Bdnf 3 336 0.70 183.48 209.82
35 INT2391 Negative_regulation of PTGS1 6 501 0.59 207.62 205.6
36 INT50670 Gene_expression of CPOX 15 763 0.76 442.13 195.02
37 INT6488 Gene_expression of Tnf 1 484 0.78 339.61 191.58
38 INT24326 Gene_expression of Ngf 3 346 0.78 218.67 184.71
39 INT10194 Positive_regulation of IL6 6 702 0.70 600.62 183.38
40 INT12602 Negative_regulation of Oprm1 1 190 0.59 36.11 177.85
41 INT19472 Gene_expression of Il1 3 554 0.76 419.75 175.35
42 INT15516 Gene_expression of Crp 1 711 0.77 615.33 173.09
43 INT438 Gene_expression of Crh 2 376 0.78 159.11 169.17
44 INT867 Gene_expression of IFNA1 23 930 0.78 594.85 168.03
45 INT1114 Localization of Ins1 1 748 0.80 192.95 165.48
46 INT5127 Localization of Lhb 1 488 0.80 50.48 162.66
47 INT3448 Positive_regulation of Gh 2 521 0.69 180.03 161.18
48 INT2640 Gene_expression of Pomc 4 424 0.78 120.72 155.37
49 INT6042 Binding of Oprm1 1 248 0.48 31.77 154.34
50 INT15515 Positive_regulation of Crp 1 700 0.70 604.24 150.15
51 INT1033 Positive_regulation of Ca2 1 507 0.68 131.76 147.64
52 INT9852 Positive_regulation of Gpt 13 563 0.70 364.64 146.82
53 INT5116 Gene_expression of IL2 1 670 0.78 291.13 146.69
54 INT812 Localization of INS 21 1026 0.81 515.6 145.31
55 INT425 Localization of PRL 64 455 0.81 189.64 144.8
56 INT9660 Regulation of TNF 10 363 0.62 312.94 139.99
57 INT4658 Binding of OPRM1 2 188 0.48 25.96 136.24
58 INT1878 Binding of HLA-B 1 440 0.48 321.16 127.36
59 INT695 Binding of POMC 1 304 0.48 56.66 126.85
60 INT6822 Gene_expression of Pdyn 1 215 0.78 35.99 125.76
61 INT5008 Localization of Calca 7 204 0.81 80.35 125.16
62 INT252 Localization of GH1 3 529 0.80 227.4 122.05
63 INT8243 Positive_regulation of Il6 2 451 0.70 358.24 119.28
64 INT17612 Gene_expression of CRP 3 676 0.78 580.61 119.03
65 INT5010 Gene_expression of Calca 1 197 0.78 85.76 118.75
66 INT9235 Negative_regulation of Gene_expression of TNF 8 346 0.59 252.98 118.61
67 INT50674 Gene_expression of PTGS2 1 459 0.78 253.33 118.51
68 INT7395 Localization of GNRH1 2 399 0.81 62.88 117.68
69 INT1438 Localization of Pomc 12 360 0.81 101.26 116.47
70 INT62124 Gene_expression of NOS1 1 444 0.78 218.08 114.85
71 INT1793 Localization of CGA 2 379 0.81 67.38 114.69
72 INT1530 Regulation of Gh 1 382 0.61 115.96 112.47
73 INT118381 Gene_expression of Il17a 7 405 0.76 306.97 112.06
74 INT11051 Positive_regulation of Gene_expression of IL6 6 415 0.69 319.21 109.3
75 INT3038 Gene_expression of INS 7 1583 0.78 1174.16 107.01
76 INT12082 Localization of IL6 3 365 0.81 241.78 105.78
77 INT12569 Localization of Oprd1 3 94 0.81 23.81 104.56
78 INT915 Positive_regulation of PRL 86 342 0.70 141.96 104.31
79 INT18009 Positive_regulation of CRP 1 518 0.70 553.03 103.74
80 INT4742 Gene_expression of Tac1 1 177 0.78 69.99 102.66
81 INT1898 Regulation of Crh 2 220 0.62 61.33 102.64
82 INT10838 Positive_regulation of IL8 1 381 0.70 295.51 101.62
83 INT397 Localization of SST 1 232 0.81 58.05 101.19
84 INT11381 Positive_regulation of IL1B 1 330 0.70 209.31 100.9
85 INT4822 Localization of Ca2 1 417 0.80 99.57 96.45
86 INT1760 Gene_expression of PTGER2 1 524 0.57 226.94 96.4
87 INT74058 Gene_expression of Nos1 2 260 0.78 80.04 95.71
88 INT29971 Gene_expression of Oprk1 18 126 0.78 35.32 93.97
89 INT11587 Gene_expression of CSF2 12 645 0.78 544.38 93.89
90 INT5865 Positive_regulation of Localization of Gh 1 282 0.69 84.86 93.5
91 INT203 Positive_regulation of Pomc 1 257 0.70 90.56 92.84
92 INT1281 Negative_regulation of Maoa 1 203 0.59 22.47 91.66
93 INT69764 Positive_regulation of Cnr1 2 126 0.70 67.8 91.49
94 INT214 Localization of AVP 13 370 0.81 208.51 91.09
95 INT74376 Gene_expression of Cnr1 2 173 0.78 73.43 89.7
96 INT18032 Positive_regulation of Oprk1 4 108 0.70 30.78 89.7
97 INT48408 Gene_expression of ICAM1 11 494 0.78 340.08 88.6
98 INT2520 Negative_regulation of Ca2 1 271 0.57 72.13 83.71
99 INT92434 Phosphorylation of Mapk1 7 287 0.82 91.65 83.46
100 INT48406 Gene_expression of Icam1 1 277 0.78 238.28 81.71
101 INT68682 Positive_regulation of VEGFA 2 640 0.70 454.14 81.65
102 INT10534 Positive_regulation of Trib3 1 209 0.60 78.75 81.48
103 INT1498 Gene_expression of Gh 8 521 0.75 220.84 81.16
104 INT2893 Localization of Oxt 4 219 0.80 28.96 79.43
105 INT920 Localization of PLOD1 3 223 0.81 42.25 78.7
106 INT749 Gene_expression of HLA-B 2 341 0.75 224.12 77.37
107 INT19771 Positive_regulation of PAG1 3 69 0.61 75.61 76.88
108 INT60691 Gene_expression of Il12a 11 331 0.78 208.03 75.96
109 INT1497 Negative_regulation of Gh 2 415 0.59 192.95 74.71
110 INT1724 Negative_regulation of ACE 2 437 0.59 315.64 74.48
111 INT7028 Localization of Pdyn 3 90 0.81 8.89 73.54
112 INT48244 Gene_expression of Il4 2 172 0.76 132.38 73.42
113 INT9236 Regulation of Gene_expression of TNF 2 204 0.62 162.66 72.99
114 INT56298 Gene_expression of IL4 1 306 0.78 182.18 72.92
115 INT39565 Gene_expression of Ptger2 1 424 0.75 229.28 72.68
116 INT11380 Negative_regulation of IL1B 2 215 0.59 125.62 72.35
117 INT15913 Negative_regulation of CYP2D6 5 174 0.59 22.45 70.91
118 INT10837 Positive_regulation of Gene_expression of IL8 2 294 0.70 190.08 70.34
119 INT79494 Positive_regulation of Gene_expression of VEGFA 8 577 0.70 442.94 69.73
120 INT53964 Negative_regulation of Prkaca 1 131 0.58 38.76 69.52
121 INT1988 Positive_regulation of Localization of Ins1 1 254 0.69 59.25 68.37
122 INT7134 Localization of KNG1 1 127 0.79 65.73 67.97
123 INT6489 Positive_regulation of Gene_expression of Tnf 1 140 0.70 92.31 67.85
124 INT5374 Gene_expression of Esr1 5 412 0.77 263.89 67.34
125 INT462 Regulation of Pomc 1 157 0.62 41.67 67.27
126 INT6486 Positive_regulation of Tnf 1 168 0.70 123.47 66.05
127 INT253 Regulation of PRL 17 184 0.62 47.27 65.79
128 INT4960 Positive_regulation of CSF2 2 285 0.70 256.73 65.73
129 INT3375 Gene_expression of IGHE 5 535 0.77 387.47 65.46
130 INT11807 Gene_expression of Il2 2 266 0.78 112 64.97
131 INT5573 Negative_regulation of Gene_expression of Penk 1 113 0.59 21.83 64.66
132 INT822 Gene_expression of ESR1 12 529 0.78 302.16 63.64
133 INT9657 Positive_regulation of Gene_expression of Il6 1 237 0.70 180.45 63.6
134 INT2056 Negative_regulation of Gnrh1 1 175 0.59 33.43 63.32
135 INT6894 Gene_expression of CNR1 3 168 0.78 74.07 62.84
136 INT10706 Regulation of Il6 1 150 0.62 93.23 62.34
137 INT17401 Gene_expression of IGF1 26 475 0.78 232.18 62.07
138 INT6761 Binding of CALCA 3 100 0.48 26.71 62.05
139 INT18981 Gene_expression of ABAT 1 78 0.68 38.35 61.36
140 INT1437 Negative_regulation of Pomc 4 132 0.59 35.22 60.97
141 INT39153 Positive_regulation of PTGS2 2 182 0.70 96.16 60.6
142 INT5058 Positive_regulation of IFNA1 7 356 0.70 245.75 60.52
143 INT17564 Gene_expression of Gpt 7 322 0.75 208.51 60.36
144 INT103924 Positive_regulation of Akt1 3 359 0.69 158.94 60.34
145 INT546 Binding of ALB 6 311 0.48 85.98 60.14
146 INT50672 Positive_regulation of CPOX 5 205 0.44 125.93 60.06
147 INT6623 Gene_expression of NA 3 231 0.78 45.78 59.36
148 INT1759 Gene_expression of TIMP1 2 267 0.77 133.87 59.29
149 INT8732 Positive_regulation of Gene_expression of Oprm1 5 76 0.70 22.59 58.83
150 INT11491 Positive_regulation of KNG1 2 128 0.67 60.41 58.74
151 INT48901 Negative_regulation of IL6 14 186 0.57 136.33 57.87
152 INT48232 Gene_expression of MMP1 1 245 0.78 96.31 57.72
153 INT68813 Transcription of Oprm1 3 93 0.71 20.11 57.65
154 INT9408 Positive_regulation of Crp 1 296 0.69 242.27 57.35
155 INT48891 Positive_regulation of Il10 1 143 0.70 101.42 56.72
156 INT4509 Gene_expression of IGG 3 426 0.76 293.69 56.64
157 INT31186 Negative_regulation of Insrr 1 81 0.37 24.91 55.94
158 INT17458 Negative_regulation of Gene_expression of FOS 1 98 0.57 36.77 55.69
159 INT69876 Negative_regulation of Nfkb1 1 147 0.58 89.81 55.5
160 INT1579 Gene_expression of PRL 33 279 0.78 119.2 55.41
161 INT4241 Regulation of CALCA 1 87 0.62 28.19 55.29
162 INT78899 Gene_expression of CCL5 2 155 0.77 84.02 55.09
163 INT49436 Binding of TRPV1 1 145 0.48 38.35 55.08
164 INT251 Regulation of INS 3 398 0.62 232.47 55.04
165 INT82650 Gene_expression of Bcl2 8 312 0.78 211.71 55.03
166 INT20375 Gene_expression of Hand1 1 213 0.60 148.51 54.53
167 INT77855 Gene_expression of Pain1 1 55 0.75 67.42 54.1
168 INT6116 Regulation of Gene_expression of Oprd1 3 69 0.62 16.43 54
169 INT9234 Negative_regulation of Gene_expression of IL6 1 171 0.59 101.61 53.15
170 INT22112 Positive_regulation of Localization of TNF 1 164 0.70 115.66 52.18
171 INT72182 Gene_expression of Mcpt1 1 167 0.75 123.7 52.15
172 INT10668 Positive_regulation of Gene_expression of Oprd1 10 61 0.69 15.21 52.12
173 INT27954 Positive_regulation of Gene_expression of Ngf 1 87 0.70 57.91 51.96
174 INT97674 Positive_regulation of Localization of Calca 3 70 0.69 27.71 51.79
175 INT5118 Regulation of SST 1 97 0.62 34.35 51.74
176 INT83199 Gene_expression of Nos3 2 193 0.78 100.72 51.57
177 INT50405 Negative_regulation of CYP3A4 78 238 0.59 53.65 51.51
178 INT62630 Positive_regulation of CNR1 3 86 0.70 40.34 51.51
179 INT12345 Gene_expression of Il2 2 142 0.78 59.17 51.21
180 INT19775 Localization of Il1 1 183 0.78 145.5 50.91
181 INT6473 Positive_regulation of Gene_expression of IL1B 2 204 0.70 117.23 50.86
182 INT1199 Positive_regulation of INS 9 579 0.70 399.64 50.43
183 INT9210 Regulation of IL6 5 166 0.62 125.61 49.95
184 INT2604 Positive_regulation of Got1 1 223 0.70 154.78 49.51
185 INT937 Positive_regulation of Oxt 2 195 0.70 37.82 49.3
186 INT117598 Regulation of ACR 19 118 0.26 41.25 48.01
187 INT106525 Phosphorylation of Akt1 1 436 0.82 183.81 47.82
188 INT2463 Localization of CCK 3 101 0.81 37.54 47.59
189 INT375 Positive_regulation of REN 2 293 0.70 152.46 47.55
190 INT2406 Gene_expression of CCK 3 85 0.78 28.04 46.67
191 INT683 Positive_regulation of AVP 10 173 0.70 74.55 46.41
192 INT66331 Gene_expression of Cacna1a 1 101 0.78 49.58 46.32
193 INT531 Gene_expression of GH1 9 376 0.75 193.45 46.24
194 INT71786 Phosphorylation of MAPK1 1 256 0.82 110.09 46.17
195 INT1322 Positive_regulation of Localization of INS 6 293 0.70 120.86 45.98
196 INT145266 Gene_expression of IL17A 2 154 0.75 109.83 45.33
197 INT4776 Localization of TAC1 1 82 0.78 16.89 45.21
198 INT18522 Positive_regulation of Gene_expression of IFNA1 4 248 0.67 160.85 44.87
199 INT1726 Positive_regulation of Kitl 1 65 0.70 38.81 44.85
200 INT3361 Positive_regulation of Esr1 1 273 0.69 208.53 44.81
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