J:Toxicol. Appl. Pharmacol.

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This page displays the top molecular interactions and top single events that were mentioned in the literature in this journal. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported in this journal. They are ordered first by their pain relevance and then by number of times they were reported in this journal. Text mining (TM) confidence, disease relevance and pain relevance are highlighted in green if they are judged to be high and red if not. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Reported in Journal Documents TM Confidence Disease Relevance Pain Relevance
1 INT53751 Positive_regulation of Cyp2e1 Positive_regulation of RYBP 1 2 0.14 0.89 1.98
2 INT129212 RYBP Positive_regulation of Tnf 2 1 0.03 1.9 1.95
3 INT12327 Igh-Dex Positive_regulation of Plec 1 1 0.03 0.73 1.57
4 INT136346 Binding of Aap and Ads1 1 2 0.09 2.95 1.44
5 INT124099 Binding of GGT5 and RYBP 1 1 0.00 0.34 1.26
6 INT124108 Binding of RYBP and Ccne1 1 1 0.09 0.34 1.26
7 INT53750 Cyp2e1 Positive_regulation of RYBP 1 1 0.14 0.44 0.99
8 INT129216 Negative_regulation of RYBP Positive_regulation of Tnf 1 1 0.01 1.24 0.98
9 INT129215 RYBP Positive_regulation of Il10 1 1 0.01 1.24 0.98
10 INT129206 RYBP Positive_regulation of Gene_expression of TGFB1 1 1 0.00 1.04 0.95
11 INT129214 RYBP Positive_regulation of Gene_expression of Il4 1 1 0.01 1.04 0.94
12 INT129213 RYBP Positive_regulation of Gene_expression of Il10 1 1 0.01 1.04 0.94
13 INT129211 RYBP Positive_regulation of Gene_expression of Tnf 1 1 0.01 1.04 0.94
14 INT114883 Akt1 Regulation of Pik3r1 2 1 0.16 0.65 0.92
15 INT138602 Negative_regulation of BCL2L2 Positive_regulation of F2 1 1 0.00 0.67 0.92
16 INT138601 BCL2L2 Positive_regulation of F2 1 1 0.00 0.66 0.91
17 INT49585 Binding of Glul and Selenbp2 1 1 0.20 0.19 0.76
18 INT34825 Aap Negative_regulation of Gsr 1 1 0.01 0.3 0.75
19 INT31776 Positive_regulation of Gclc Positive_regulation of G6pd 1 1 0.29 0.19 0.75
20 INT34823 Regulation of Binding of Ldha and Akr7a3 1 1 0.43 0.28 0.72
21 INT34824 Binding of Ldha and Akr7a3 1 1 0.36 0.28 0.71
22 INT81631 Selenbp2 Negative_regulation of Fas 1 1 0.03 0.77 0.67
23 INT81630 Selenbp2 Negative_regulation of Positive_regulation of Fas 1 1 0.03 0.77 0.67
24 INT112701 Bid Regulation of RFFL 1 1 0.00 0.52 0.62
25 INT112699 Bid Regulation of Bax 1 1 0.25 0.51 0.61
26 INT115146 MAPK1 Positive_regulation of EGR1 3 1 0.13 2.43 0.57
27 INT112700 Aap Positive_regulation of RFFL 1 1 0.00 0.5 0.57
28 INT43515 SEMA6A Negative_regulation of RYBP 1 1 0.06 0.07 0.54
29 INT142273 KITLG Positive_regulation of Gene_expression of Tnf 1 1 0.07 0.9 0.43
30 INT144966 MAPK1 Positive_regulation of Localization of EGR1 1 1 0.08 0.83 0.35
31 INT151132 Negative_regulation of Map2k7 Negative_regulation of Gene_expression of Litaf 1 1 0.01 0.29 0.32
32 INT55269 Cp Negative_regulation of Cyb5a 1 1 0.01 0.54 0.3
33 INT113668 Mapk7 Positive_regulation of Positive_regulation of Rhox7 1 1 0.03 0 0.24
34 INT144967 MAPK1 Positive_regulation of Positive_regulation of EGR1 1 1 0.08 0.63 0.24
35 INT113669 Mapk7 Positive_regulation of Gene_expression of Fos 1 1 0.54 0 0.22
36 INT28722 Binding of T2 and Hdac11 1 2 0.11 0.14 0.18
37 INT132253 Tm2d1 Regulation of Chrna9 1 1 0.02 0.09 0.14
38 INT48595 NT5C3 Positive_regulation of CA2 1 1 0.01 0 0.13
39 INT48594 NT5C3 Positive_regulation of NA 1 1 0.00 0 0.13
40 INT69687 Tgfb1 Positive_regulation of Gene_expression of Il4 1 1 0.23 0 0.12
41 INT69689 Tgfb1 Positive_regulation of Tgfb1 Positive_regulation of Rel 1 1 0.55 0 0.12
42 INT69688 Tgfb1 Positive_regulation of Rel 1 1 0.50 0 0.12
43 INT28724 T2 Negative_regulation of Binding of T2 and Hdac11 1 1 0.03 0.08 0.1
44 INT28723 Negative_regulation of Binding of T2 and Hdac11 1 1 0.10 0.08 0.1
45 INT65902 GSTK1 Regulation of Positive_regulation of Gnat3 1 1 0.02 0 0

Single Events

The table below shows the top 100 pain related interactions that have been reported in this journal. They are ordered first by their pain relevance and then by number of times they were reported in this journal. Text mining (TM) confidence, disease relevance and pain relevance are highlighted in green if they are judged to be high and red if not. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Reported in Journal Documents TM Confidence Disease Relevance Pain Relevance
1 INT5200 Gene_expression of Fos 7 3083 0.78 894.43 1639.02
2 INT796 Gene_expression of Penk 2 1902 0.78 275.47 1057.59
3 INT6483 Gene_expression of TNF 1 3152 0.78 2515.62 929.82
4 INT5202 Positive_regulation of Gene_expression of Fos 3 1163 0.70 319.28 684
5 INT58061 Gene_expression of Trpv1 2 1117 0.78 451.54 637.59
6 INT797 Regulation of Penk 3 812 0.62 111.13 542.24
7 INT9238 Gene_expression of IL6 3 1575 0.78 1135.66 424.22
8 INT1395 Negative_regulation of Penk 3 537 0.59 87.33 389.81
9 INT6056 Negative_regulation of Gene_expression of Fos 1 601 0.59 193.05 386.84
10 INT76660 Gene_expression of Trpv1 2 691 0.78 329.46 386.42
11 INT18357 Gene_expression of TRPV1 3 825 0.78 307.11 382.81
12 INT439 Localization of Gnrh1 1 976 0.81 100.96 363.25
13 INT876 Localization of Gh1 3 843 0.80 67.75 340.82
14 INT5059 Positive_regulation of TNF 1 1050 0.70 896.51 322.81
15 INT5379 Gene_expression of Fos 1 656 0.78 255.5 292.54
16 INT9158 Gene_expression of Tnf 3 722 0.78 522.01 277.68
17 INT9381 Positive_regulation of TRPV1 2 523 0.70 187.4 276.05
18 INT6852 Localization of TNF 5 883 0.81 705.95 270.84
19 INT10832 Gene_expression of IL8 1 1050 0.78 698.72 270
20 INT9659 Gene_expression of Il6 1 991 0.78 715.11 265.57
21 INT68684 Gene_expression of VEGFA 2 2371 0.78 1742.52 259.2
22 INT626 Localization of CALCA 1 289 0.81 125.39 221.15
23 INT767 Localization of Gnrhr 2 565 0.80 106.68 214.57
24 INT2651 Positive_regulation of Pomc 1 403 0.70 95.72 206.24
25 INT2391 Negative_regulation of PTGS1 1 501 0.59 207.62 205.6
26 INT9132 Negative_regulation of Prkcg 1 279 0.59 88.05 203.47
27 INT94952 Positive_regulation of Mapk14 3 305 0.70 197.83 186.61
28 INT10194 Positive_regulation of IL6 1 702 0.70 600.62 183.38
29 INT66280 Gene_expression of Nos2 2 534 0.78 330.78 157.07
30 INT60694 Gene_expression of Il10 7 567 0.78 369.48 143.69
31 INT5380 Positive_regulation of Gene_expression of Fos 1 243 0.70 105.65 131.05
32 INT115386 Gene_expression of Ppara 1 779 0.77 549.99 128.36
33 INT65600 Positive_regulation of Casp3 6 376 0.70 198.44 128.03
34 INT65054 Positive_regulation of Nfkb1 1 285 0.70 149.33 126.73
35 INT8243 Positive_regulation of Il6 2 451 0.70 358.24 119.28
36 INT12339 Localization of IL8 3 437 0.81 251.87 117.39
37 INT20374 Gene_expression of Il4 4 515 0.76 306.15 114.12
38 INT27096 Positive_regulation of Nfkb1 1 325 0.70 195.11 109.06
39 INT12082 Localization of IL6 7 365 0.81 241.78 105.78
40 INT10838 Positive_regulation of IL8 1 381 0.70 295.51 101.62
41 INT5940 Negative_regulation of Avp 1 236 0.59 67.86 101.2
42 INT4822 Localization of Ca2 1 417 0.80 99.57 96.45
43 INT3537 Positive_regulation of Car2 3 413 0.56 103.51 94.35
44 INT77435 Positive_regulation of Nos2 3 343 0.70 208.49 91.43
45 INT9516 Negative_regulation of Gabrg1 1 149 0.53 27.83 91.02
46 INT71789 Positive_regulation of MAPK1 1 396 0.70 234.44 89.27
47 INT22967 Positive_regulation of RYBP 16 94 0.56 37.04 85.92
48 INT2520 Negative_regulation of Ca2 2 271 0.57 72.13 83.71
49 INT84546 Positive_regulation of Ppara 2 481 0.70 334.21 83.45
50 INT2431 Positive_regulation of Mpo 3 275 0.70 211.99 78.47
51 INT9382 Regulation of TRPV1 1 149 0.62 53.99 77.46
52 INT15769 Gene_expression of Il1b 4 146 0.78 114.51 75.35
53 INT6489 Positive_regulation of Gene_expression of Tnf 5 140 0.70 92.31 67.85
54 INT19511 Localization of Il6 1 212 0.81 118.17 67.67
55 INT102546 Gene_expression of Ccl2 2 197 0.78 192.8 67.41
56 INT15613 Negative_regulation of Ptgs2 1 160 0.59 71.08 65.08
57 INT1169 Negative_regulation of Bche 1 322 0.59 149.22 61.27
58 INT11318 Gene_expression of Gtf3a 1 274 0.52 183.82 60.89
59 INT2761 Regulation of Gabrg1 2 119 0.61 18.8 60.52
60 INT17564 Gene_expression of Gpt 1 322 0.75 208.51 60.36
61 INT14740 Gene_expression of TGFB1 3 272 0.78 168.48 60.18
62 INT1536 Negative_regulation of NA 1 244 0.55 52.67 59.79
63 INT3920 Localization of Ldha 17 241 0.81 83.08 58.72
64 INT770 Regulation of Localization of Gnrhr 2 127 0.61 17.91 58.23
65 INT48901 Negative_regulation of IL6 2 186 0.57 136.33 57.87
66 INT18883 Negative_regulation of RYBP 8 53 0.56 21.14 57.52
67 INT96937 Gene_expression of Mmp9 4 191 0.75 150.3 56.01
68 INT52692 Gene_expression of Ptgs2 2 160 0.78 85.06 55.73
69 INT69876 Negative_regulation of Nfkb1 4 147 0.58 89.81 55.5
70 INT52800 Negative_regulation of Gene_expression of Tnf 2 142 0.59 92.27 55.47
71 INT117223 Gene_expression of TLR4 1 348 0.78 206.18 54.42
72 INT3213 Gene_expression of Ins1 1 511 0.76 357.59 53.32
73 INT9234 Negative_regulation of Gene_expression of IL6 1 171 0.59 101.61 53.15
74 INT1032 Regulation of Ca2 2 202 0.52 54.91 53.03
75 INT72182 Gene_expression of Mcpt1 4 167 0.75 123.7 52.15
76 INT2604 Positive_regulation of Got1 1 223 0.70 154.78 49.51
77 INT375 Positive_regulation of REN 2 293 0.70 152.46 47.55
78 INT374 Positive_regulation of Ldha 5 212 0.70 107.08 47.43
79 INT9383 Localization of TRPV1 2 98 0.81 33.23 46.24
80 INT4656 Localization of RYBP 5 49 0.77 5.28 46.21
81 INT6979 Positive_regulation of CA2 1 206 0.67 50.79 44.97
82 INT3361 Positive_regulation of Esr1 1 273 0.69 208.53 44.81
83 INT17561 Localization of Car2 1 303 0.79 60.95 44.52
84 INT83953 Gene_expression of Cxcl2 1 140 0.75 113.07 43.65
85 INT60695 Positive_regulation of Gene_expression of Il10 2 154 0.70 120.28 43.07
86 INT85943 Negative_regulation of Nos2 1 161 0.59 108.56 42.65
87 INT11180 Binding of RYBP 18 52 0.46 13.86 42.53
88 INT11939 Negative_regulation of Il6 1 138 0.59 87.46 41.24
89 INT4887 Gene_expression of Tac4 1 70 0.77 11.66 40.97
90 INT11560 Positive_regulation of CASP3 1 236 0.70 184.33 39.38
91 INT1596 Negative_regulation of Oprl1 1 61 0.57 13.5 38.41
92 INT4449 Positive_regulation of NA 1 179 0.55 40.26 37.82
93 INT18774 Gene_expression of RYBP 2 67 0.65 47.66 37.59
94 INT48222 Positive_regulation of Localization of IL8 1 123 0.59 78.04 37.2
95 INT95646 Negative_regulation of Faah 7 63 0.59 25.61 36.78
96 INT80690 Positive_regulation of MAPK8 1 223 0.68 125.63 36.75
97 INT48959 Positive_regulation of Positive_regulation of Prkcg 1 52 0.70 16.47 36.49
98 INT5743 Localization of NA 8 104 0.59 14.35 35.29
99 INT8747 Positive_regulation of Ins1 5 221 0.69 154.28 35.15
100 INT49519 Gene_expression of P2rx7 1 84 0.76 36.88 34.69
101 INT5489 Localization of CA2 2 172 0.80 39.46 33.56
102 INT234 Binding of Alb 1 151 0.48 52.34 32.97
103 INT20307 Positive_regulation of Cyp2e1 1 70 0.70 23.59 32.49
104 INT22939 Gene_expression of Csf2 5 164 0.78 85.1 32.22
105 INT114881 Gene_expression of Akt1 1 227 0.78 102.49 31.81
106 INT86780 Positive_regulation of Hmox1 4 145 0.70 117.09 31.18
107 INT129207 Gene_expression of Cxcl1 1 114 0.75 68.54 30.82
108 INT54302 Positive_regulation of Gene_expression of Il4 3 126 0.68 86.18 30.75
109 INT11650 Negative_regulation of Gpt 1 122 0.59 69.15 30.36
110 INT46833 Positive_regulation of SGSM3 1 56 0.67 24.49 30.31
111 INT9133 Negative_regulation of Positive_regulation of Prkcg 1 37 0.59 10.95 30.06
112 INT50230 Positive_regulation of Localization of IL6 1 105 0.70 69.21 29.52
113 INT65598 Negative_regulation of Positive_regulation of Casp3 1 45 0.59 18.36 28.59
114 INT122039 Positive_regulation of Gene_expression of Ppara 1 144 0.68 113.55 28.55
115 INT3286 Positive_regulation of Gpt 2 90 0.69 45.08 28.34
116 INT57692 Positive_regulation of Gene_expression of Il1b 2 50 0.67 43.54 28.29
117 INT48202 Gene_expression of Tgfb1 3 146 0.78 89.93 27.76
118 INT12129 Gene_expression of CYP3A4 1 107 0.78 23.11 27.6
119 INT115385 Negative_regulation of Ppara 4 154 0.58 129.05 27.58
120 INT16428 Positive_regulation of Gtf3a 1 135 0.20 106.44 26.67
121 INT11773 Gene_expression of Tac1 1 56 0.77 10 25.72
122 INT9886 Gene_expression of Ptgs1 1 92 0.77 40.66 25.31
123 INT48248 Gene_expression of Scn10a 2 38 0.78 19.3 25.05
124 INT92105 Transcription of Trpv1 2 47 0.71 27.47 25.01
125 INT2614 Gene_expression of CGA 2 187 0.78 105.89 24.77
126 INT106272 Positive_regulation of Positive_regulation of Mapk14 1 39 0.70 32.08 24.71
127 INT9377 Positive_regulation of Positive_regulation of TRPV1 1 43 0.70 15.81 24.47
128 INT51029 Negative_regulation of Il1b 1 34 0.57 29.34 23.62
129 INT18884 Regulation of RYBP 4 25 0.38 11.43 23.2
130 INT17962 Regulation of Car2 1 124 0.41 33.98 22.71
131 INT7678 Localization of Alb 1 142 0.81 80.93 22.49
132 INT4369 Gene_expression of Ldha 1 157 0.76 88.12 22.45
133 INT48081 Localization of Il1b 2 46 0.80 21.59 22.4
134 INT14733 Positive_regulation of Gene_expression of TGFB1 3 71 0.69 49.89 22.2
135 INT39914 Negative_regulation of Cyp1a2 1 44 0.58 10.04 22
136 INT47859 Negative_regulation of Cyp2e1 1 41 0.59 16.92 21.72
137 INT52693 Positive_regulation of Gene_expression of Ptgs2 1 57 0.70 25.51 21.18
138 INT112029 Positive_regulation of Pik3r1 2 90 0.67 38.76 20.95
139 INT73593 Gene_expression of BAX 1 173 0.76 147.81 20.94
140 INT52529 Regulation of Nfkb1 1 48 0.61 26.2 20.89
141 INT52106 Negative_regulation of Localization of IL8 1 57 0.52 22.81 20.8
142 INT1792 Positive_regulation of CGA 2 123 0.70 64.73 20.79
143 INT53575 Regulation of Gene_expression of Tnf 1 46 0.62 34.35 20.63
144 INT48144 Gene_expression of Fgf2 1 117 0.78 43 20.48
145 INT8765 Positive_regulation of Cyp3a23/3a1 3 63 0.67 22.28 20.39
146 INT49985 Transcription of Il6 2 62 0.72 40.13 20.29
147 INT20305 Gene_expression of Cyp2e1 1 53 0.78 19.75 19.54
148 INT1278 Negative_regulation of Ldha 1 93 0.59 37.66 19.36
149 INT712 Positive_regulation of LDHA 3 160 0.70 175.25 19.11
150 INT51054 Negative_regulation of Localization of IL6 2 45 0.59 24.48 18.97
151 INT11803 Positive_regulation of Il2 1 62 0.70 31.44 18.93
152 INT3060 Negative_regulation of Bche 1 94 0.59 46.75 18.51
153 INT14111 Positive_regulation of Cyp2c22 8 41 0.67 7.24 17.88
154 INT113602 Positive_regulation of Gene_expression of Ccl2 2 48 0.70 48.71 17.85
155 INT9656 Regulation of Gene_expression of Il6 1 57 0.62 33.3 17.71
156 INT53393 Positive_regulation of Cyp3a62 14 25 0.70 7.56 17.69
157 INT116950 Negative_regulation of MAPK8 1 103 0.57 44.48 17.53
158 INT17237 Regulation of Esr1 1 74 0.43 49.09 17.25
159 INT3206 Positive_regulation of Got1 1 39 0.69 19.36 17.02
160 INT93361 Gene_expression of Trp53 1 208 0.78 175.35 16.65
161 INT109929 Phosphorylation of MAPK8 1 102 0.81 39.98 16.54
162 INT81087 Gene_expression of ASIC3 1 30 0.75 13.62 16.54
163 INT1020 Negative_regulation of BCHE 2 109 0.59 44.86 16.4
164 INT49986 Transcription of Tnf 4 25 0.72 18.3 16.22
165 INT2480 Negative_regulation of Got1 1 43 0.51 14.47 16.09
166 INT112027 Gene_expression of Pik3r1 1 58 0.75 30.9 15.95
167 INT50618 Gene_expression of Dio1 1 48 0.74 17.37 15.91
168 INT1752 Negative_regulation of Ache 2 109 0.59 42.05 15.73
169 INT68913 Gene_expression of Cd14 2 55 0.76 38.99 15.67
170 INT20336 Positive_regulation of CYP2E1 1 48 0.70 19.26 15.66
171 INT4340 Positive_regulation of Localization of Ldha 4 46 0.70 14.52 15.66
172 INT81627 Gene_expression of Fas 1 120 0.78 115.51 15.36
173 INT113606 Positive_regulation of Gene_expression of Mmp9 2 46 0.64 44 15.07
174 INT81088 Gene_expression of ASIC1 1 26 0.77 17.8 15.07
175 INT9904 Gene_expression of CYP2E1 2 64 0.78 13.11 14.65
176 INT11980 Positive_regulation of Tac1 1 27 0.69 6.17 14.5
177 INT151120 Negative_regulation of Tlr4 1 18 0.59 21.09 14.46
178 INT109511 Gene_expression of Bax 1 133 0.78 113.22 14.36
179 INT46797 Negative_regulation of Cyp3a62 6 27 0.59 7.06 13.97
180 INT3796 Gene_expression of Ighm 1 130 0.77 69.61 13.78
181 INT17565 Regulation of Gpt 1 85 0.60 43.64 13.68
182 INT78480 Localization of Nfkb1 3 39 0.80 23.14 13.64
183 INT18882 Negative_regulation of Localization of RYBP 1 11 0.49 1.15 13.51
184 INT53747 Positive_regulation of Cyp2e1 5 34 0.70 29.03 13.39
185 INT18191 Negative_regulation of Cyp3a23/3a1 1 48 0.57 10.21 13.38
186 INT12325 Gene_expression of Plec 1 47 0.72 11.92 13.35
187 INT104954 Negative_regulation of Positive_regulation of Mapk14 2 29 0.58 17.71 13.31
188 INT20381 Localization of Il2 1 71 0.77 34.23 13.03
189 INT81629 Positive_regulation of Fas 3 58 0.70 59.63 12.94
190 INT22213 Localization of Gpt 1 52 0.78 34.05 12.94
191 INT55255 Positive_regulation of Localization of Il6 1 48 0.69 24.88 12.76
192 INT10585 Localization of NAGLU 2 53 0.80 23.32 12.75
193 INT58226 Negative_regulation of Gene_expression of Il1b 2 24 0.57 18.09 12.68
194 INT1827 Gene_expression of Aap 1 11 0.67 9.37 12.66
195 INT2129 Positive_regulation of F2 3 83 0.70 58.95 12.63
196 INT9011 Negative_regulation of Nrtim1 1 15 0.30 2.35 12.58
197 INT51028 Regulation of Il1b 1 28 0.60 21.15 12.47
198 INT12191 Negative_regulation of Localization of Ldha 1 35 0.59 13.71 12.35
199 INT81626 Positive_regulation of Positive_regulation of Casp3 1 34 0.69 16.75 12.18
200 INT92686 Gene_expression of Ctgf 5 51 0.77 34.4 11.93
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