J:Toxicol. Lett.

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This page displays the top molecular interactions and top single events that were mentioned in the literature in this journal. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported in this journal. They are ordered first by their pain relevance and then by number of times they were reported in this journal. Text mining (TM) confidence, disease relevance and pain relevance are highlighted in green if they are judged to be high and red if not. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Reported in Journal Documents TM Confidence Disease Relevance Pain Relevance
1 INT128903 Binding of RNASE2 and Itga7 1 1 0.00 0.08 0.15
2 INT47351 Binding of Ralbp1 and Ccl4 1 1 0.11 0.17 0.14
3 INT47352 Positive_regulation of Binding of Ralbp1 and Ccl4 1 1 0.14 0.17 0.14

Single Events

The table below shows the top 100 pain related interactions that have been reported in this journal. They are ordered first by their pain relevance and then by number of times they were reported in this journal. Text mining (TM) confidence, disease relevance and pain relevance are highlighted in green if they are judged to be high and red if not. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Reported in Journal Documents TM Confidence Disease Relevance Pain Relevance
1 INT796 Gene_expression of Penk 1 1902 0.78 275.47 1057.59
2 INT797 Regulation of Penk 1 812 0.62 111.13 542.24
3 INT467 Gene_expression of POMC 1 1048 0.78 332.8 394.16
4 INT9987 Gene_expression of Abat 1 296 0.78 95.46 226.34
5 INT1033 Positive_regulation of Ca2 2 507 0.68 131.76 147.64
6 INT9852 Positive_regulation of Gpt 9 563 0.70 364.64 146.82
7 INT2780 Regulation of Gene_expression of Penk 1 265 0.62 32.45 143.88
8 INT20374 Gene_expression of Il4 1 515 0.76 306.15 114.12
9 INT4822 Localization of Ca2 3 417 0.80 99.57 96.45
10 INT96917 Positive_regulation of Mapk14 1 261 0.70 173.29 88.79
11 INT22967 Positive_regulation of RYBP 4 94 0.56 37.04 85.92
12 INT1080 Negative_regulation of Ache 7 343 0.59 108.51 72.4
13 INT14049 Positive_regulation of GRIN1 1 102 0.70 48.31 71.06
14 INT15913 Negative_regulation of CYP2D6 3 174 0.59 22.45 70.91
15 INT18883 Negative_regulation of RYBP 3 53 0.56 21.14 57.52
16 INT48891 Positive_regulation of Il10 1 143 0.70 101.42 56.72
17 INT4509 Gene_expression of IGG 2 426 0.76 293.69 56.64
18 INT96914 Phosphorylation of Mapk14 1 168 0.82 108.46 53.32
19 INT1032 Regulation of Ca2 1 202 0.52 54.91 53.03
20 INT62543 Gene_expression of Icam1 3 231 0.78 187.58 52.71
21 INT2604 Positive_regulation of Got1 1 223 0.70 154.78 49.51
22 INT374 Positive_regulation of Ldha 1 212 0.70 107.08 47.43
23 INT110023 Negative_regulation of Mapk14 1 127 0.59 84.27 45.42
24 INT613 Gene_expression of Alb 2 268 0.78 149.84 42.78
25 INT18774 Gene_expression of RYBP 1 67 0.65 47.66 37.59
26 INT56870 Gene_expression of CYP2D6 2 87 0.78 8.83 37.53
27 INT13186 Positive_regulation of Il4 1 113 0.68 71.22 31.4
28 INT10797 Binding of CYP2D6 1 86 0.48 15.09 31.16
29 INT54302 Positive_regulation of Gene_expression of Il4 2 126 0.68 86.18 30.75
30 INT11650 Negative_regulation of Gpt 1 122 0.59 69.15 30.36
31 INT2569 Gene_expression of Ache 1 120 0.78 26.29 26.89
32 INT276 Regulation of Ache 1 83 0.62 16.75 25.99
33 INT2040 Positive_regulation of CYP2B6 1 95 0.69 34.3 25.6
34 INT61664 Regulation of GRIN1 1 38 0.60 16.45 25.35
35 INT50039 Positive_regulation of Il4 1 48 0.55 34.8 23.34
36 INT47859 Negative_regulation of Cyp2e1 3 41 0.59 16.92 21.72
37 INT12265 Positive_regulation of IgG 7 168 0.63 104.89 19.76
38 INT6807 Regulation of Gabrd 1 39 0.62 9.22 18.74
39 INT14546 Positive_regulation of Localization of Ca2 2 93 0.67 31.09 18.72
40 INT3060 Negative_regulation of Bche 1 94 0.59 46.75 18.51
41 INT3952 Negative_regulation of ALB 1 116 0.59 72.18 18.35
42 INT71680 Gene_expression of CCL3 1 43 0.75 33.7 18.01
43 INT116950 Negative_regulation of MAPK8 1 103 0.57 44.48 17.53
44 INT62546 Positive_regulation of Gene_expression of Icam1 2 60 0.70 59.52 16.9
45 INT56447 Positive_regulation of Icam1 1 64 0.64 64.14 16.16
46 INT10360 Positive_regulation of Ifng 1 33 0.68 21.73 15.19
47 INT96911 Positive_regulation of Phosphorylation of Mapk14 1 46 0.70 43.03 15.15
48 INT79227 Negative_regulation of Gene_expression of Icam1 2 45 0.59 41.65 14.97
49 INT505 Positive_regulation of GPT 1 89 0.67 69.38 14.94
50 INT7523 Regulation of ADRA1D 1 42 0.45 11.63 14.52
51 INT22098 Positive_regulation of Il2 1 27 0.69 14.77 14.1
52 INT111529 Phosphorylation of Mapk3 1 41 0.80 21.14 13.72
53 INT110025 Positive_regulation of Positive_regulation of Mapk14 1 39 0.63 20.67 12.71
54 INT14510 Gene_expression of SOD1 1 208 0.76 88.56 12.4
55 INT96915 Phosphorylation of Mapk8 1 73 0.81 40.69 11.44
56 INT80251 Binding of Nos1 2 21 0.30 8.24 11.31
57 INT71189 Gene_expression of Cyp1a2 1 24 0.78 11.39 11.12
58 INT62580 Gene_expression of Cyp2e1 1 31 0.78 15.4 11.08
59 INT11649 Negative_regulation of Positive_regulation of Gpt 1 25 0.59 13.94 10.87
60 INT39699 Negative_regulation of Positive_regulation of RYBP 1 11 0.41 3.73 10.42
61 INT12455 Negative_regulation of Adra2a 1 30 0.54 5.63 10.14
62 INT47860 Negative_regulation of Cyp1a2 1 20 0.57 6.06 10
63 INT22965 Positive_regulation of Pah 1 42 0.61 41.41 8.84
64 INT8903 Gene_expression of IFNA2 2 58 0.71 38.23 8.68
65 INT3287 Gene_expression of Gpt 1 50 0.75 23.69 8.57
66 INT88919 Positive_regulation of Casp9 1 39 0.70 28.64 8.18
67 INT1433 Regulation of MUC7 1 21 0.60 1.7 8.18
68 INT16131 Negative_regulation of GBE1 1 37 0.30 10.32 8.15
69 INT96912 Positive_regulation of Phosphorylation of Mapk8 1 29 0.69 18.33 8.14
70 INT46221 Positive_regulation of Gene_expression of IgG 2 46 0.53 33.66 7.7
71 INT1771 Positive_regulation of Ace 1 31 0.68 10.47 7.46
72 INT39417 Gene_expression of Fcer2a 1 65 0.76 32.1 7.37
73 INT4228 Gene_expression of CAT 1 50 0.75 20.62 7.18
74 INT7873 Positive_regulation of Ugt2b 2 36 0.70 0.72 6.59
75 INT4060 Gene_expression of Bche 2 17 0.70 5.23 6.59
76 INT96218 Positive_regulation of Pgr 5 17 0.68 5.23 6.57
77 INT68653 Negative_regulation of JUN 1 34 0.58 14.27 6.56
78 INT3795 Positive_regulation of Ighm 4 46 0.68 22.43 6.47
79 INT22943 Positive_regulation of Positive_regulation of Gpt 2 23 0.47 16.09 5.55
80 INT87022 Gene_expression of Apc 1 68 0.67 46.98 5.22
81 INT27415 Negative_regulation of Positive_regulation of Got1 1 15 0.51 10.99 5.14
82 INT5297 Regulation of IFNA2 2 20 0.56 10.81 5.13
83 INT59555 Binding of RYR1 1 39 0.42 8.65 4.92
84 INT102654 Positive_regulation of Pln 9 10 0.48 3.53 4.19
85 INT123827 Positive_regulation of Phosphorylation of Mapk3 1 10 0.67 5.22 3.82
86 INT19189 Localization of IL1A 1 14 0.78 9.02 3.78
87 INT187 Positive_regulation of Ephx1 5 17 0.69 0.51 3.69
88 INT71602 Negative_regulation of Trp53 1 84 0.59 67.77 3.68
89 INT10650 Regulation of Ugt2b7 1 7 0.60 1.12 3.67
90 INT35508 Negative_regulation of Gapdh 1 6 0.54 3.67 3.63
91 INT18192 Regulation of Gene_expression of Alb 1 16 0.44 9.38 3.57
92 INT38303 Binding of Gpt 1 21 0.47 15.84 3.43
93 INT184 Regulation of Ephx1 1 10 0.60 0.54 3.27
94 INT15648 Positive_regulation of RYR1 1 30 0.67 12.03 3.26
95 INT50765 Positive_regulation of Fcer2a 2 23 0.68 10.22 2.92
96 INT39908 Gene_expression of Cyp27b1 1 16 0.69 4.8 2.83
97 INT10510 Negative_regulation of Igh-6 1 13 0.45 10.37 2.68
98 INT55629 Regulation of Mgst1 1 12 0.53 2.7 2.62
99 INT96217 Positive_regulation of Ift20 3 4 0.45 0.65 2.62
100 INT35465 Negative_regulation of Pfkm 1 8 0.57 3.84 2.6
101 INT4934 Negative_regulation of Unc5c 1 2 0.05 0.59 2.4
102 INT72890 Positive_regulation of Gene_expression of Fcer2a 2 12 0.17 6.81 2.25
103 INT10651 Positive_regulation of Ugt2b7 1 5 0.67 0.16 2.22
104 INT52072 Negative_regulation of Ces1c 1 6 0.31 1.37 2.13
105 INT20164 Positive_regulation of B3gat2 3 8 0.55 1.36 2.11
106 INT46109 Binding of SERPINF2 1 6 0.37 1.08 2.06
107 INT57115 Negative_regulation of NT5E 2 8 0.57 4.35 2.03
108 INT82441 Binding of Cyp4f18 1 4 0.23 1.07 1.99
109 INT85302 Negative_regulation of Cyp2b21 1 6 0.20 8.94 1.8
110 INT96216 Negative_regulation of Positive_regulation of Pgr 1 2 0.37 0.74 1.72
111 INT67504 Binding of Niacr1 1 3 0.48 0.78 1.7
112 INT1560 Regulation of Nudt1 1 2 0.09 0 1.66
113 INT2847 Positive_regulation of Negative_regulation of Ache 1 8 0.49 1.09 1.65
114 INT38856 Positive_regulation of Ccl4 1 24 0.69 9.55 1.62
115 INT22966 Negative_regulation of Positive_regulation of Pah 1 2 0.50 2.03 1.56
116 INT122523 Negative_regulation of Negative_regulation of RYBP 1 1 0.08 0.45 1.32
117 INT152951 Negative_regulation of LEF1 1 5 0.41 3.22 1.31
118 INT61938 Negative_regulation of Pxk 2 5 0.36 3.05 1.2
119 INT154057 Gene_expression of Ear1 1 14 0.41 9.72 1.12
120 INT12264 Positive_regulation of Positive_regulation of IgG 2 6 0.30 2.01 1.09
121 INT47348 Binding of Ccl4 1 8 0.37 3.24 1.08
122 INT80253 Gene_expression of Kcna1 1 4 0.75 1.88 1.01
123 INT96215 Negative_regulation of Positive_regulation of Ift20 1 1 0.23 0.06 0.92
124 INT95330 Gene_expression of Ephx1 2 4 0.67 6.72 0.7
125 INT102655 Positive_regulation of Positive_regulation of Ighm 1 2 0.32 0.74 0.67
126 INT61937 Regulation of Pxk 2 1 0.49 0 0.6
127 INT61110 Positive_regulation of Binding of Gpt 1 2 0.50 1.13 0.56
128 INT73524 Positive_regulation of Ear1 1 7 0.27 4.82 0.54
129 INT47488 Binding of Khk 1 1 0.48 0.1 0.51
130 INT95328 Gene_expression of Gstp1 1 11 0.61 8.59 0.48
131 INT75001 Gene_expression of Cyp1b1 1 11 0.66 4.23 0.48
132 INT103584 Negative_regulation of Mat2a 2 1 0.46 0 0.36
133 INT29373 Negative_regulation of Antxr2 1 1 0.58 0.77 0.25
134 INT136287 Regulation of Positive_regulation of Icam1 1 1 0.39 1.32 0.24
135 INT47349 Positive_regulation of Positive_regulation of Ccl4 1 4 0.49 1.92 0.2
136 INT38232 Positive_regulation of Cyp4b1 1 2 0.18 0 0.2
137 INT128902 Binding of RNASE2 1 1 0.00 0.08 0.15
138 INT47350 Binding of Ralbp1 1 1 0.10 0.17 0.14
139 INT45858 Positive_regulation of Sec1 1 2 0.12 0 0.12
140 INT41701 Positive_regulation of Positive_regulation of B3gat2 1 1 0.37 0 0.09
141 INT95329 Gene_expression of Cryz 1 1 0.23 0.3 0.07
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