J:Toxicol. Sci.

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This page displays the top molecular interactions and top single events that were mentioned in the literature in this journal. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported in this journal. They are ordered first by their pain relevance and then by number of times they were reported in this journal. Text mining (TM) confidence, disease relevance and pain relevance are highlighted in green if they are judged to be high and red if not. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Reported in Journal Documents TM Confidence Disease Relevance Pain Relevance
1 INT167618 Rho Regulation of App 1 1 0.17 0.88 0.55
2 INT167620 Rock2 Regulation of App 1 1 0.13 0.87 0.55
3 INT167621 Psenen Positive_regulation of App 1 1 0.02 0.86 0.44
4 INT167617 Bace2 Positive_regulation of App 1 1 0.06 0.87 0.44
5 INT167619 Protein_catabolism of Ppp2cb Positive_regulation of App 1 1 0.00 0.88 0.44
6 INT285598 Maoa Negative_regulation of Aldh3a1 1 1 0.01 0.18 0.36
7 INT285604 ROS1 Positive_regulation of Gene_expression of Tlr4 1 1 0.01 1.14 0.2
8 INT285605 Binding of ROS1 and Tlr4 1 1 0.01 1.25 0.16
9 INT285602 Trib3 Regulation of Gene_expression of Nos2 1 1 0.00 0.48 0.07
10 INT285603 Akt1 Regulation of Gene_expression of Nos2 1 1 0.02 0.48 0.04

Single Events

The table below shows the top 100 pain related interactions that have been reported in this journal. They are ordered first by their pain relevance and then by number of times they were reported in this journal. Text mining (TM) confidence, disease relevance and pain relevance are highlighted in green if they are judged to be high and red if not. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Reported in Journal Documents TM Confidence Disease Relevance Pain Relevance
1 INT6483 Gene_expression of TNF 4 3152 0.78 2515.62 929.82
2 INT9238 Gene_expression of IL6 4 1575 0.78 1135.66 424.22
3 INT5059 Positive_regulation of TNF 4 1050 0.70 896.51 322.81
4 INT6852 Localization of TNF 2 883 0.81 705.95 270.84
5 INT10832 Gene_expression of IL8 2 1050 0.78 698.72 270
6 INT5972 Gene_expression of IL1B 1 948 0.78 510.91 263.97
7 INT68684 Gene_expression of VEGFA 1 2371 0.78 1742.52 259.2
8 INT95787 Positive_regulation of Mapk1 1 568 0.70 226.51 220.94
9 INT6481 Binding of TNF 3 624 0.48 510.2 214.82
10 INT767 Localization of Gnrhr 1 565 0.80 106.68 214.57
11 INT6482 Positive_regulation of Gene_expression of TNF 1 659 0.70 569.88 210
12 INT10194 Positive_regulation of IL6 2 702 0.70 600.62 183.38
13 INT55879 Gene_expression of CCL2 1 421 0.78 240.74 166.02
14 INT1114 Localization of Ins1 3 748 0.80 192.95 165.48
15 INT66280 Gene_expression of Nos2 3 534 0.78 330.78 157.07
16 INT120811 Gene_expression of Gopc 1 1174 0.59 428.49 150.55
17 INT49134 Gene_expression of Grin1 1 270 0.78 84.78 148.61
18 INT9852 Positive_regulation of Gpt 4 563 0.70 364.64 146.82
19 INT9660 Regulation of TNF 3 363 0.62 312.94 139.99
20 INT7533 Gene_expression of Tlr4 1 720 0.78 343.22 121.57
21 INT64201 Negative_regulation of Trpv1 2 203 0.59 79.18 119.75
22 INT50674 Gene_expression of PTGS2 1 459 0.78 253.33 118.51
23 INT7341 Positive_regulation of Grin1 2 169 0.70 65.86 118.38
24 INT48593 Positive_regulation of NOS1 1 420 0.68 226.15 114.71
25 INT170025 Gene_expression of Fig4 1 588 0.67 183.27 113.32
26 INT11051 Positive_regulation of Gene_expression of IL6 1 415 0.69 319.21 109.3
27 INT60526 Gene_expression of IL10 1 449 0.78 292.71 107.84
28 INT69440 Gene_expression of ROS1 6 752 0.78 477.64 103.83
29 INT90091 Gene_expression of GOPC 2 967 0.67 366.22 103.6
30 INT10838 Positive_regulation of IL8 1 381 0.70 295.51 101.62
31 INT65500 Gene_expression of App 3 605 0.78 429.94 98.31
32 INT1281 Negative_regulation of Maoa 1 203 0.59 22.47 91.66
33 INT77435 Positive_regulation of Nos2 3 343 0.70 208.49 91.43
34 INT48767 Negative_regulation of NOS1 1 312 0.59 154.25 90.32
35 INT7180 Negative_regulation of Trib3 1 180 0.51 68.48 88.01
36 INT1472 Positive_regulation of Ins1 1 349 0.69 146.2 86.36
37 INT92434 Phosphorylation of Mapk1 2 287 0.82 91.65 83.46
38 INT10534 Positive_regulation of Trib3 1 209 0.60 78.75 81.48
39 INT3657 Gene_expression of Ins1 1 514 0.78 321.69 75.76
40 INT5056 Gene_expression of IFNG 1 216 0.78 137.52 74.57
41 INT14049 Positive_regulation of GRIN1 1 102 0.70 48.31 71.06
42 INT171145 Positive_regulation of Fig4 2 274 0.59 93.55 69.81
43 INT4960 Positive_regulation of CSF2 2 285 0.70 256.73 65.73
44 INT67981 Positive_regulation of CCL2 1 165 0.70 136.84 61.85
45 INT103924 Positive_regulation of Akt1 1 359 0.69 158.94 60.34
46 INT79093 Positive_regulation of Nos1 1 101 0.70 46.89 59.61
47 INT169926 Positive_regulation of Gopc 7 416 0.46 157.8 58.67
48 INT48901 Negative_regulation of IL6 1 186 0.57 136.33 57.87
49 INT1200 Negative_regulation of Ins1 8 274 0.58 155.17 56.14
50 INT52264 Gene_expression of IK 8 180 0.77 90.87 51.87
51 INT49028 Positive_regulation of Nos1 1 102 0.70 34.73 51.05
52 INT53083 Gene_expression of Ptgs2 1 153 0.78 90.04 50.39
53 INT9210 Regulation of IL6 1 166 0.62 125.61 49.95
54 INT57021 Positive_regulation of Gene_expression of Grin1 1 62 0.70 24.77 47.31
55 INT145266 Gene_expression of IL17A 1 154 0.75 109.83 45.33
56 INT6979 Positive_regulation of CA2 1 206 0.67 50.79 44.97
57 INT2275 Negative_regulation of Localization of Ins1 3 183 0.59 51.02 44.94
58 INT613 Gene_expression of Alb 3 268 0.78 149.84 42.78
59 INT157666 Positive_regulation of GOPC 1 335 0.60 120.19 42.75
60 INT170054 Negative_regulation of Gopc 1 280 0.38 117.89 42.4
61 INT13354 Transcription of TNF 2 108 0.72 85.81 42.32
62 INT61619 Gene_expression of IL12A 1 194 0.77 146.07 41.97
63 INT69437 Positive_regulation of ROS1 5 328 0.58 222.83 40.56
64 INT92437 Positive_regulation of Phosphorylation of Mapk1 4 113 0.70 32.19 40.29
65 INT77434 Positive_regulation of Gene_expression of Nos2 2 151 0.69 96.76 38.94
66 INT3758 Gene_expression of ALB 1 326 0.78 184.65 38.75
67 INT63349 Gene_expression of PECAM1 1 199 0.75 166.03 36.76
68 INT13501 Binding of Drd2 1 65 0.48 23.76 35.6
69 INT72651 Gene_expression of TH1L 1 114 0.75 80.15 35.15
70 INT74563 Positive_regulation of Gene_expression of ROS1 3 258 0.61 168.18 34.08
71 INT666 Gene_expression of Jun 1 124 0.78 54.61 33.67
72 INT73498 Gene_expression of IL13 1 117 0.44 83.85 32.26
73 INT96913 Positive_regulation of Mapk8 1 179 0.69 130.44 32.2
74 INT86437 Binding of IL6 3 154 0.48 121.22 29.3
75 INT47712 Positive_regulation of App 3 135 0.69 101.38 28.94
76 INT3286 Positive_regulation of Gpt 1 90 0.69 45.08 28.34
77 INT14690 Localization of CSF2 2 124 0.80 85.17 27.26
78 INT12681 Regulation of Trib3 1 76 0.53 23.92 26.58
79 INT3559 Negative_regulation of Localization of Gnrhr 1 73 0.58 18.89 26.41
80 INT86062 Positive_regulation of Tnfrsf1a 1 51 0.69 40.69 26.2
81 INT80791 Gene_expression of Slc6a3 10 113 0.78 11.89 25.76
82 INT89854 Regulation of Nos2 1 49 0.61 42.58 24.1
83 INT66026 Gene_expression of Cxcl1 1 74 0.78 31.87 23.37
84 INT93738 Gene_expression of Tnfrsf1a 2 63 0.74 57.66 23.09
85 INT7535 Negative_regulation of Tlr4 1 111 0.56 56.84 21.37
86 INT11625 Localization of App 1 98 0.78 55.46 20.86
87 INT170444 Binding of Gopc 1 172 0.39 45.05 20.71
88 INT16794 Binding of App 2 103 0.48 64.87 19.79
89 INT16445 Gene_expression of IL1A 2 60 0.78 44.46 19.19
90 INT65856 Positive_regulation of TP53 1 138 0.67 112.65 16.71
91 INT93361 Gene_expression of Trp53 1 208 0.78 175.35 16.65
92 INT10834 Binding of IL8 1 65 0.48 41.66 16.53
93 INT77433 Regulation of Gene_expression of Nos2 2 49 0.62 35.07 16.33
94 INT20622 Gene_expression of LDHA 1 107 0.76 77.97 16.3
95 INT6110 Negative_regulation of Gene_expression of Ins1 1 83 0.56 60.59 16.07
96 INT170855 Negative_regulation of GOPC 1 188 0.38 70.92 15.41
97 INT54356 Regulation of Slc6a3 1 48 0.58 5.86 15.24
98 INT106745 Localization of CRP 1 65 0.81 66.44 15.21
99 INT12087 Regulation of Localization of TNF 1 44 0.62 28.71 15.17
100 INT65697 Positive_regulation of GRIN3B 2 23 0.69 12.52 13.78
101 INT17565 Regulation of Gpt 2 85 0.60 43.64 13.68
102 INT61624 Positive_regulation of Gene_expression of IL12A 1 50 0.56 33.07 13.07
103 INT69436 Negative_regulation of Gene_expression of ROS1 1 81 0.38 46.58 12.22
104 INT112003 Localization of ROS1 1 94 0.73 66.32 12.16
105 INT15756 Positive_regulation of Gene_expression of Jun 2 29 0.69 16.58 12.06
106 INT8548 Gene_expression of HP 1 86 0.77 47.62 11.94
107 INT170601 Positive_regulation of Gene_expression of GOPC 1 122 0.43 42.79 11.68
108 INT109315 Gene_expression of Mapk8 1 70 0.78 45.46 11.65
109 INT96915 Phosphorylation of Mapk8 2 73 0.81 40.69 11.44
110 INT98789 Negative_regulation of Gene_expression of App 1 54 0.58 40.27 11.15
111 INT79556 Gene_expression of GRIN3B 1 16 0.77 7.71 10.75
112 INT95565 Positive_regulation of IL12A 1 47 0.56 33.96 10.16
113 INT80110 Regulation of Positive_regulation of TNF 2 34 0.44 25.79 9.78
114 INT75137 Regulation of Akt1 1 74 0.48 37.89 9.7
115 INT68960 Gene_expression of Ptger4 1 42 0.67 15.75 9.64
116 INT107307 Transcription of IFNA1 1 30 0.52 18.16 9.61
117 INT14301 Binding of CSF2 1 82 0.48 67.95 8.98
118 INT73558 Regulation of IK 9 23 0.23 12.02 8.73
119 INT3287 Gene_expression of Gpt 5 50 0.75 23.69 8.57
120 INT22383 Binding of IL2 1 59 0.48 39.06 8.56
121 INT113987 Localization of IK 2 29 0.23 16.73 8.25
122 INT96912 Positive_regulation of Phosphorylation of Mapk8 3 29 0.69 18.33 8.14
123 INT81777 Negative_regulation of Gene_expression of IK 2 22 0.08 11.55 8.09
124 INT94082 Regulation of Gene_expression of IK 2 19 0.23 10.03 7.93
125 INT28457 Positive_regulation of Slc6a3 4 26 0.50 3.64 7.76
126 INT69160 Positive_regulation of IL5 1 41 0.65 36.04 7.75
127 INT79456 Gene_expression of PDE4A 2 35 0.77 19.42 7.42
128 INT91667 Localization of IL12A 1 39 0.74 25.51 7.36
129 INT3757 Positive_regulation of Gene_expression of ALB 1 45 0.69 23.73 6.85
130 INT132822 Localization of IL13 1 26 0.67 22.85 6.66
131 INT60527 Transcription of IL10 1 16 0.56 13.57 6.42
132 INT66227 Gene_expression of COX18 2 41 0.50 26.91 6.26
133 INT4422 Positive_regulation of Gene_expression of Alb 1 30 0.50 18.56 6.12
134 INT48393 Positive_regulation of Localization of CSF2 2 14 0.60 8.92 6.1
135 INT99506 Negative_regulation of Bcl2l1 2 25 0.58 15.7 6.09
136 INT275272 Positive_regulation of Positive_regulation of Tnfrsf1a 1 8 0.48 6.44 5.97
137 INT67060 Negative_regulation of Transcription of TNF 1 17 0.59 12.94 5.88
138 INT94118 Localization of Tnfrsf1a 1 9 0.72 7.24 5.81
139 INT123563 Negative_regulation of Rock1 1 7 0.55 16.56 5.78
140 INT63351 Negative_regulation of Gene_expression of PECAM1 1 19 0.52 16.06 5.73
141 INT85417 Positive_regulation of Gene_expression of IK 1 17 0.09 9.38 5.73
142 INT131944 Gene_expression of Mki67 1 30 0.53 6.58 5.63
143 INT84673 Localization of Nos1 1 19 0.80 5.01 5.62
144 INT5490 Binding of CA2 1 52 0.36 9.73 5.53
145 INT145929 Regulation of Bax 1 20 0.60 18.12 5.35
146 INT64723 Regulation of Positive_regulation of IL6 1 13 0.61 12.59 5.19
147 INT135291 Positive_regulation of Positive_regulation of Mapk8 2 24 0.64 19.37 5.16
148 INT131717 Positive_regulation of Gene_expression of Mapk8 1 18 0.55 14.25 5.02
149 INT106524 Phosphorylation of Jun 2 23 0.80 15.35 4.78
150 INT99504 Negative_regulation of Bax 1 19 0.56 8.89 4.44
151 INT187836 Binding of Tnfrsf1a 1 19 0.46 18.08 4.33
152 INT68255 Regulation of Positive_regulation of IL8 1 12 0.41 5.71 3.91
153 INT174277 Positive_regulation of Positive_regulation of Gopc 3 23 0.33 8.08 3.73
154 INT73500 Regulation of IL13 1 12 0.36 10.37 3.53
155 INT17195 Positive_regulation of Gstp1 1 16 0.67 4.37 3.46
156 INT143998 Binding of IK 2 11 0.34 2.44 3.42
157 INT81871 Positive_regulation of Aldh3a1 1 17 0.69 3.15 3.12
158 INT69822 Binding of Ptger3 1 9 0.39 2.98 2.97
159 INT85750 Regulation of Positive_regulation of Nos2 1 10 0.54 7.78 2.83
160 INT68962 Positive_regulation of Ptger4 1 20 0.67 7.3 2.79
161 INT16447 Binding of IL1A 1 10 0.45 4.01 2.78
162 INT113892 Binding of Cat 1 6 0.48 3.95 2.65
163 INT263088 Positive_regulation of Mki67 1 15 0.19 2.13 2.57
164 INT4419 Gene_expression of GOT1 1 20 0.65 22.53 2.53
165 INT61907 Negative_regulation of Ebp 1 9 0.37 4.77 2.49
166 INT114898 Regulation of Transcription of TNF 1 4 0.35 2.69 2.18
167 INT113906 Regulation of Positive_regulation of CCL2 1 4 0.27 3.2 2.17
168 INT275279 Positive_regulation of Localization of Tnfrsf1a 1 3 0.48 1.13 2.17
169 INT125080 Positive_regulation of Positive_regulation of TP53 1 21 0.58 16.16 1.98
170 INT112089 Gene_expression of Cav1 4 73 0.75 23.8 1.97
171 INT91663 Positive_regulation of Localization of IL12A 1 9 0.27 5.91 1.95
172 INT66225 Positive_regulation of COX18 1 9 0.37 4 1.86
173 INT134443 Binding of Bax 1 10 0.47 5.62 1.84
174 INT158374 Negative_regulation of Aadac 1 13 0.07 7.19 1.76
175 INT20347 Positive_regulation of PF4 1 5 0.67 2.91 1.72
176 INT166339 Positive_regulation of Gene_expression of GRIN3B 1 2 0.47 0.86 1.72
177 INT35492 Negative_regulation of Aldh3a1 2 7 0.46 1.34 1.59
178 INT234761 Binding of IL13 1 6 0.35 4.18 1.55
179 INT154009 Binding of Upb1 2 1 0.39 0.39 1.54
180 INT79455 Positive_regulation of Gene_expression of PDE4A 2 3 0.67 2.07 1.5
181 INT20509 Positive_regulation of Negative_regulation of Ins1 1 7 0.48 2.8 1.46
182 INT20633 Positive_regulation of Gene_expression of LDHA 1 15 0.49 15.94 1.42
183 INT121827 Gene_expression of Ccl21a 1 12 0.75 3.08 1.35
184 INT140877 Regulation of Ptger4 1 6 0.36 2.2 1.23
185 INT168135 Localization of H3 2 10 0.30 4 1.15
186 INT3288 Positive_regulation of Gene_expression of Gpt 1 9 0.49 5.55 1.1
187 INT35491 Regulation of Aldh3a1 1 4 0.61 0.63 1.08
188 INT156805 Gene_expression of Ebp 1 6 0.40 6.09 1.07
189 INT97071 Regulation of Gstp1 1 1 0.43 0.59 1
190 INT99555 Gene_expression of EBI3 1 3 0.09 2.6 0.9
191 INT167607 Positive_regulation of Binding of App 1 8 0.50 2.97 0.86
192 INT57277 Localization of ANGPTL5 1 5 0.19 2.15 0.84
193 INT169792 Positive_regulation of Gene_expression of Ptger4 1 5 0.60 2 0.82
194 INT112090 Negative_regulation of Gene_expression of Cav1 2 8 0.57 3.5 0.78
195 INT147743 Positive_regulation of Ntp 1 3 0.43 1.72 0.72
196 INT61147 Protein_catabolism of App 1 3 0.60 3.76 0.63
197 INT188223 Positive_regulation of Gene_expression of EBI3 1 2 0.07 0.95 0.63
198 INT327768 Regulation of Transcription of IL10 1 1 0.17 0.13 0.61
199 INT167608 Regulation of Rock2 1 2 0.33 2.47 0.59
200 INT163222 Protein_catabolism of a 1 2 1.00 1.17 0.56
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