J:Toxicology

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This page displays the top molecular interactions and top single events that were mentioned in the literature in this journal. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported in this journal. They are ordered first by their pain relevance and then by number of times they were reported in this journal. Text mining (TM) confidence, disease relevance and pain relevance are highlighted in green if they are judged to be high and red if not. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Reported in Journal Documents TM Confidence Disease Relevance Pain Relevance
1 INT140653 IGF1 Negative_regulation of Protein_catabolism of PARP1 1 1 0.32 0.63 0.98
2 INT140652 IGF1 Positive_regulation of Phosphorylation of MAPK1 1 1 0.26 0.63 0.98
3 INT74872 Igh-Dex Positive_regulation of Chd7 1 1 0.01 0.5 0.89
4 INT117482 CFTR Negative_regulation of THRB 1 1 0.01 0.15 0.51
5 INT117483 SFXN3 Negative_regulation of THRB 1 1 0.15 0.15 0.51
6 INT148466 Ccl4 Positive_regulation of Hmox1 1 1 0.28 0.06 0.47
7 INT148465 Positive_regulation of Ccl4 Positive_regulation of Gclc 1 1 0.32 0.06 0.38
8 INT148467 Ccl4 Positive_regulation of Gclc 1 1 0.32 0.05 0.37
9 INT76865 Lmo4 Positive_regulation of Sds 1 1 0.02 0.38 0.2
10 INT76866 Negative_regulation of Lmo4 Positive_regulation of Sds 1 1 0.02 0.38 0.2
11 INT24660 Positive_regulation of Binding of ELANE and SERPINA1 1 1 0.17 0.73 0.08
12 INT24659 Binding of ELANE and SERPINA1 1 1 0.13 0.73 0.08
13 INT12987 LIF Regulation of Localization of Prl 1 1 0.09 0 0.07

Single Events

The table below shows the top 100 pain related interactions that have been reported in this journal. They are ordered first by their pain relevance and then by number of times they were reported in this journal. Text mining (TM) confidence, disease relevance and pain relevance are highlighted in green if they are judged to be high and red if not. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Reported in Journal Documents TM Confidence Disease Relevance Pain Relevance
1 INT5200 Gene_expression of Fos 1 3083 0.78 894.43 1639.02
2 INT158 Localization of Prl 1 2431 0.81 378.96 952.2
3 INT1912 Gene_expression of Calca 2 1152 0.78 453.25 739.84
4 INT5202 Positive_regulation of Gene_expression of Fos 1 1163 0.70 319.28 684
5 INT155 Positive_regulation of Prl 1 1233 0.70 317.93 457.82
6 INT1395 Negative_regulation of Penk 1 537 0.59 87.33 389.81
7 INT6580 Negative_regulation of Ptgs1 3 929 0.59 381.53 376.26
8 INT5660 Binding of Oprd1 3 477 0.48 71.86 342.06
9 INT4893 Gene_expression of Tacr1 1 366 0.78 129.67 213.92
10 INT156 Negative_regulation of Prl 1 542 0.59 131.97 192.24
11 INT13353 Positive_regulation of Tnf 1 332 0.70 248.75 148.1
12 INT5061 Negative_regulation of Mme 3 306 0.59 51.97 136.9
13 INT48953 Positive_regulation of Nos2 1 486 0.70 239.85 131.87
14 INT695 Binding of POMC 2 304 0.48 56.66 126.85
15 INT4824 Positive_regulation of Tacr1 1 169 0.70 66.1 123.46
16 INT20374 Gene_expression of Il4 1 515 0.76 306.15 114.12
17 INT69440 Gene_expression of ROS1 2 752 0.78 477.64 103.83
18 INT77435 Positive_regulation of Nos2 3 343 0.70 208.49 91.43
19 INT71789 Positive_regulation of MAPK1 3 396 0.70 234.44 89.27
20 INT10166 Localization of Tnf 12 237 0.81 153.95 88.64
21 INT48408 Gene_expression of ICAM1 1 494 0.78 340.08 88.6
22 INT54571 Positive_regulation of NFKB1 2 263 0.70 138.99 87.32
23 INT4857 Regulation of Tacr1 2 115 0.62 39.01 84.52
24 INT1080 Negative_regulation of Ache 3 343 0.59 108.51 72.4
25 INT58400 Negative_regulation of Tnf 1 182 0.59 129.97 71
26 INT7534 Gene_expression of Ifng 3 193 0.78 111.02 68.6
27 INT1536 Negative_regulation of NA 1 244 0.55 52.67 59.79
28 INT3920 Localization of Ldha 3 241 0.81 83.08 58.72
29 INT18883 Negative_regulation of RYBP 1 53 0.56 21.14 57.52
30 INT5017 Negative_regulation of Tacr1 1 76 0.58 17 57.07
31 INT52800 Negative_regulation of Gene_expression of Tnf 2 142 0.59 92.27 55.47
32 INT4241 Regulation of CALCA 2 87 0.62 28.19 55.29
33 INT48952 Negative_regulation of Nos2 1 204 0.59 101.73 53.15
34 INT52611 Negative_regulation of Ptgs2 1 142 0.59 66.31 52.71
35 INT53083 Gene_expression of Ptgs2 1 153 0.78 90.04 50.39
36 INT2604 Positive_regulation of Got1 2 223 0.70 154.78 49.51
37 INT7093 Negative_regulation of CYP2B6 3 146 0.58 37.3 48.39
38 INT17881 Gene_expression of LEP 1 278 0.78 221.61 48.31
39 INT374 Positive_regulation of Ldha 3 212 0.70 107.08 47.43
40 INT71786 Phosphorylation of MAPK1 1 256 0.82 110.09 46.17
41 INT5307 Regulation of Tnf 2 87 0.62 78.71 43.4
42 INT82883 Positive_regulation of Ccl2 2 105 0.69 84.96 42.27
43 INT2429 Negative_regulation of Mpo 1 128 0.59 93.76 39.57
44 INT3971 Positive_regulation of Alb 1 175 0.70 98.46 36.45
45 INT20380 Gene_expression of Il5 1 172 0.78 104.75 34.78
46 INT49214 Gene_expression of Cd4 1 269 0.78 154.22 34.05
47 INT4403 Binding of CYP2B6 1 113 0.48 21.17 33.83
48 INT11650 Negative_regulation of Gpt 1 122 0.59 69.15 30.36
49 INT3286 Positive_regulation of Gpt 3 90 0.69 45.08 28.34
50 INT5653 Positive_regulation of ELANE 2 136 0.70 72.78 27.94
51 INT2609 Localization of ELANE 2 111 0.81 50.22 26.63
52 INT52801 Regulation of Gene_expression of Tnf 2 55 0.62 48.74 26.59
53 INT9886 Gene_expression of Ptgs1 1 92 0.77 40.66 25.31
54 INT58301 Positive_regulation of Mpo 1 87 0.70 80.19 23.99
55 INT66026 Gene_expression of Cxcl1 1 74 0.78 31.87 23.37
56 INT47741 Negative_regulation of Flvcr2 1 43 0.51 5.72 23.37
57 INT50039 Positive_regulation of Il4 2 48 0.55 34.8 23.34
58 INT66208 Positive_regulation of Positive_regulation of NFKB1 1 45 0.68 20.17 22.62
59 INT4369 Gene_expression of Ldha 4 157 0.76 88.12 22.45
60 INT35711 Positive_regulation of Sdcbp 1 110 0.60 50.45 22.11
61 INT1561 Negative_regulation of Dnahc8 1 59 0.59 18.12 20.99
62 INT73593 Gene_expression of BAX 2 173 0.76 147.81 20.94
63 INT1512 Binding of Prl 2 73 0.48 26.22 20.63
64 INT12951 Negative_regulation of Cat 1 126 0.57 64.39 20.61
65 INT519 Negative_regulation of Comt 1 52 0.59 17.65 20.39
66 INT20305 Gene_expression of Cyp2e1 1 53 0.78 19.75 19.54
67 INT1278 Negative_regulation of Ldha 6 93 0.59 37.66 19.36
68 INT66751 Negative_regulation of Localization of Tnf 6 48 0.59 26 19.36
69 INT91462 Positive_regulation of Phosphorylation of MAPK1 1 99 0.67 40.28 18.99
70 INT28951 Negative_regulation of IGF1 1 133 0.59 75.77 18.9
71 INT87861 Gene_expression of Il18 5 33 0.78 30.44 18.42
72 INT9246 Positive_regulation of Cat 2 113 0.70 52.73 18.04
73 INT53393 Positive_regulation of Cyp3a62 2 25 0.70 7.56 17.69
74 INT80223 Positive_regulation of Hmox1 3 128 0.68 77.71 17.64
75 INT11977 Positive_regulation of Tac4 2 26 0.69 3.91 17.15
76 INT3206 Positive_regulation of Got1 1 39 0.69 19.36 17.02
77 INT2432 Positive_regulation of Cp 1 41 0.67 31.1 16.68
78 INT15166 Positive_regulation of Mme 2 40 0.70 13.01 16.24
79 INT47742 Binding of Flvcr2 1 26 0.42 3.28 15.87
80 INT4340 Positive_regulation of Localization of Ldha 1 46 0.70 14.52 15.66
81 INT10360 Positive_regulation of Ifng 1 33 0.68 21.73 15.19
82 INT32706 Gene_expression of Cyp3a23/3a1 2 51 0.65 19.48 15.06
83 INT11980 Positive_regulation of Tac1 1 27 0.69 6.17 14.5
84 INT39733 Localization of NFKB1 1 59 0.79 22.76 13.99
85 INT35120 Gene_expression of Sdcbp 1 68 0.67 21.33 13.96
86 INT13118 Positive_regulation of Ina 1 48 0.69 7.39 13.85
87 INT69435 Negative_regulation of ROS1 1 74 0.51 50.38 13.71
88 INT18191 Negative_regulation of Cyp3a23/3a1 1 48 0.57 10.21 13.38
89 INT91817 Positive_regulation of RETNLB 1 22 0.34 21.4 13.12
90 INT44 Positive_regulation of Adra1a 1 30 0.68 7.09 12.73
91 INT109223 Negative_regulation of Cdk5 3 14 0.59 3.27 12.73
92 INT3969 Positive_regulation of Sds 1 27 0.69 7.52 12.31
93 INT520 Binding of Comt 1 24 0.48 8.98 12.21
94 INT16870 Negative_regulation of Gsr 1 27 0.59 10.28 11.81
95 INT787 Localization of Ptgs1 1 31 0.80 12.36 11.55
96 INT11307 Negative_regulation of pcp 1 30 0.48 7.86 11.53
97 INT65713 Localization of ICAM1 3 42 0.81 39.55 11.49
98 INT3597 Positive_regulation of Pla2g1b 1 37 0.63 17.94 11.41
99 INT23122 Gene_expression of Ptger3 1 31 0.72 11.94 11.37
100 INT48956 Negative_regulation of Positive_regulation of Nos2 1 34 0.46 13.15 11.15
101 INT8589 Positive_regulation of Positive_regulation of Tacr1 1 14 0.69 7.85 10.86
102 INT118390 Positive_regulation of Nfe2l2 3 82 0.70 20.41 10.61
103 INT9385 Localization of LDHA 1 74 0.81 31.67 10.5
104 INT95492 Gene_expression of Nefh 1 20 0.67 12.68 10.46
105 INT39699 Negative_regulation of Positive_regulation of RYBP 1 11 0.41 3.73 10.42
106 INT348 Regulation of Adra1a 1 25 0.45 3.33 10.27
107 INT120509 Gene_expression of Cat 2 65 0.77 50.9 9.75
108 INT73596 Positive_regulation of Gene_expression of BAX 2 43 0.67 40.97 9.22
109 INT80037 Gene_expression of BAK1 4 58 0.75 39.49 9.08
110 INT107087 Positive_regulation of Gene_expression of Cyp2e1 1 20 0.70 8.89 9.04
111 INT101602 Positive_regulation of Cdk5 4 15 0.70 4.1 8.96
112 INT80420 Gene_expression of IFI27 3 145 0.78 63.61 8.83
113 INT48860 Regulation of Localization of Tnf 2 25 0.61 20.68 8.78
114 INT15768 Gene_expression of Il1a 1 20 0.71 9.31 8.78
115 INT113845 Protein_catabolism of PARP1 1 54 0.88 43.86 8.77
116 INT68744 Localization of Cxcl1 5 18 0.80 8.65 8.6
117 INT2512 Negative_regulation of Cp 3 27 0.51 10.15 8.37
118 INT45234 Binding of Ldha 4 20 0.37 9.8 8.18
119 INT39301 Gene_expression of Chd7 2 50 0.26 27.06 8.13
120 INT1138 Positive_regulation of IgG-2a 1 16 0.68 5.59 8.11
121 INT2971 Regulation of IGHE 1 42 0.61 28.81 7.87
122 INT126583 Positive_regulation of PARP1 1 50 0.68 41.44 7.78
123 INT85751 Positive_regulation of Positive_regulation of Nos2 1 40 0.60 23.53 7.72
124 INT10821 Positive_regulation of Abo 3 32 0.67 9.43 7.65
125 INT22919 Negative_regulation of Gpt 2 18 0.55 6.84 7.4
126 INT95499 Negative_regulation of Nefh 1 9 0.59 8.97 7.13
127 INT47540 Binding of Cp 1 20 0.41 15.54 7.01
128 INT69441 Regulation of Gene_expression of ROS1 1 38 0.50 26.78 6.78
129 INT29845 Positive_regulation of Sds 3 11 0.62 3.69 6.63
130 INT7873 Positive_regulation of Ugt2b 3 36 0.70 0.72 6.59
131 INT74865 Gene_expression of Igh-Dex 1 16 0.22 8.95 6.59
132 INT7205 Positive_regulation of HBG1 2 65 0.69 40.35 6.37
133 INT35780 Positive_regulation of Mt1a 5 9 0.55 4.9 6.08
134 INT12818 Regulation of IgG-2a 2 9 0.37 3.23 6.07
135 INT3645 Positive_regulation of Grhpr 1 17 0.42 3.64 6.06
136 INT143357 Binding of Ros1 1 48 0.36 27.76 6
137 INT118388 Localization of Nfe2l2 2 40 0.81 9.59 5.89
138 INT112530 Localization of Ptgs2 1 13 0.70 7.77 5.86
139 INT146594 Negative_regulation of Gene_expression of LEP 1 25 0.42 18.88 5.71
140 INT29674 Gene_expression of Ada 2 16 0.78 4.59 5.69
141 INT101604 Regulation of Cdk5 3 10 0.61 2.2 5.53
142 INT65712 Positive_regulation of Localization of ICAM1 2 14 0.70 16.72 5.5
143 INT35536 Negative_regulation of CAT 1 26 0.57 14.39 5.38
144 INT87420 Gene_expression of BCL2L1 1 56 0.75 48.84 5.32
145 INT39900 Positive_regulation of Gene_expression of Ldha 2 36 0.50 20.35 5.22
146 INT99549 Gene_expression of CDKN1B 3 30 0.75 17 5.15
147 INT68244 Positive_regulation of Ighg1 1 60 0.61 48.86 5.01
148 INT66211 Positive_regulation of Localization of NFKB1 1 20 0.68 8.18 5.01
149 INT70539 Negative_regulation of Cxcl1 1 13 0.57 7.15 4.58
150 INT101594 Positive_regulation of Cd40 1 36 0.69 16.14 4.56
151 INT140199 Positive_regulation of Gene_expression of Cyp3a23/3a1 1 9 0.45 4.91 4.56
152 INT12791 Gene_expression of Xdh 1 12 0.62 7.2 4.54
153 INT37863 Regulation of HBG2 1 11 0.61 3.95 4.34
154 INT103345 Positive_regulation of Gene_expression of BAK1 3 10 0.57 6.4 4.19
155 INT15229 Positive_regulation of CNDP1 1 21 0.69 15.86 4.06
156 INT61118 Gene_expression of Nefl 1 11 0.75 4.02 4.02
157 INT521 Negative_regulation of Lrtomt 2 8 0.55 2.83 3.96
158 INT101857 Negative_regulation of BCL2L1 1 22 0.57 23.56 3.95
159 INT3970 Positive_regulation of Sord 1 9 0.70 4.29 3.93
160 INT20303 Regulation of Cyp2e1 1 11 0.61 2.46 3.84
161 INT115773 Negative_regulation of Localization of Ptgs2 1 6 0.43 2.99 3.81
162 INT79096 Binding of Cyp2e1 1 12 0.48 4.41 3.8
163 INT119606 Regulation of Gene_expression of LEP 1 17 0.45 17.96 3.75
164 INT76707 Negative_regulation of Gene_expression of Ptger3 1 6 0.20 2.56 3.73
165 INT36142 Negative_regulation of Hmgcr 1 33 0.46 15.91 3.54
166 INT94408 Positive_regulation of Gene_expression of IFI27 1 28 0.65 12.89 3.53
167 INT22891 Positive_regulation of Localization of ELANE 1 16 0.69 11.52 3.42
168 INT28390 Negative_regulation of Mt1a 1 4 0.36 1.13 3.39
169 INT69990 Negative_regulation of Nefl 1 11 0.59 2.82 3.38
170 INT12981 Binding of Cort 1 6 0.48 2.76 3.37
171 INT22431 Negative_regulation of HBG2 1 20 0.58 6.6 3.33
172 INT102634 Transcription of Hmox1 1 22 0.62 4.5 3.3
173 INT118393 Positive_regulation of Localization of Nfe2l2 2 9 0.70 2.82 3.3
174 INT9126 Negative_regulation of Xdh 1 20 0.58 8.58 3.28
175 INT56601 Positive_regulation of Ccl4 1 9 0.47 6.27 3.28
176 INT52493 Positive_regulation of Positive_regulation of Tac4 1 3 0.13 0.45 3.21
177 INT69564 Binding of Cyp3a23/3a1 1 11 0.34 4.67 3.2
178 INT79553 Localization of Il12a 1 9 0.31 5.85 3.16
179 INT84320 Negative_regulation of Positive_regulation of Mpo 1 11 0.46 8 3.09
180 INT92632 Gene_expression of Vsig2 1 48 0.50 19.93 3.04
181 INT24795 Regulation of Igh-6 2 7 0.51 3.08 2.93
182 INT22194 Gene_expression of Xdh 2 20 0.75 10.03 2.83
183 INT85750 Regulation of Positive_regulation of Nos2 1 10 0.54 7.78 2.83
184 INT118394 Positive_regulation of Positive_regulation of Nfe2l2 1 13 0.70 1.4 2.81
185 INT11519 Negative_regulation of Coc 1 8 0.50 3.96 2.74
186 INT23669 Binding of St8sia2 1 24 0.47 11.37 2.69
187 INT11769 Regulation of Mptp1 1 8 0.60 6.38 2.68
188 INT63238 Gene_expression of Mt1 1 27 0.65 10.86 2.53
189 INT99548 Positive_regulation of Gene_expression of CDKN1B 1 12 0.67 6.79 2.5
190 INT49984 Localization of Il1a 1 5 0.77 3.61 2.42
191 INT92610 Positive_regulation of Ik 1 10 0.51 2.22 2.36
192 INT26363 Negative_regulation of CS 1 8 0.26 2.49 2.36
193 INT49139 Positive_regulation of Positive_regulation of Tac1 1 4 0.68 1.74 2.24
194 INT38095 Negative_regulation of Positive_regulation of Got1 1 3 0.20 1.97 2.16
195 INT3938 Localization of Rbp4 1 5 0.79 0.39 2.15
196 INT20164 Positive_regulation of B3gat2 1 8 0.55 1.36 2.11
197 INT17268 Localization of PLG 1 9 0.78 11.71 2.06
198 INT121126 Positive_regulation of RNF34 1 9 0.04 6.83 2.05
199 INT35745 Negative_regulation of AGL 1 29 0.50 9.16 2.03
200 INT107091 Regulation of Gene_expression of Cyp2e1 1 4 0.62 2.17 2.03
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