J:Trials

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This page displays the top molecular interactions and top single events that were mentioned in the literature in this journal. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported in this journal. They are ordered first by their pain relevance and then by number of times they were reported in this journal. Text mining (TM) confidence, disease relevance and pain relevance are highlighted in green if they are judged to be high and red if not. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Reported in Journal Documents TM Confidence Disease Relevance Pain Relevance
1 INT175329 Binding of ICAM1 and ITGAL 14 3 0.18 10.06 2.81
2 INT194863 Binding of IL1R1 and IL1RN 5 1 0.09 2.23 1.64
3 INT229094 Binding of IL1RN and Il1r1 1 3 0.01 1.9 1.5
4 INT235709 Binding of NA and SSR1 1 1 0.07 0.72 1.08
5 INT229085 IL1RN Negative_regulation of Positive_regulation of IL1R1 1 2 0.12 1.72 0.68
6 INT106744 Binding of CRP and EGFL7 2 1 0.07 2.35 0.51
7 INT229095 Binding of IL1R1 and Il1r1 1 1 0.00 0.64 0.5
8 INT341428 EPO Positive_regulation of NGF 1 1 0.52 0.37 0.48
9 INT341427 EPO Positive_regulation of BDNF 1 1 0.52 0.36 0.48
10 INT341426 EPO Regulation of NGF 1 1 0.51 0.5 0.47
11 INT341425 EPO Regulation of BDNF 1 1 0.51 0.5 0.47
12 INT290269 KNG1 Positive_regulation of Binding of MID1 1 1 0.02 1.06 0.41
13 INT290270 KNG1 Positive_regulation of MID1 1 1 0.02 1.06 0.41
14 INT229087 IL1R1 Negative_regulation of ACCS 1 1 0.03 0.86 0.33
15 INT229088 IL1R1 Positive_regulation of Gene_expression of IL6 1 1 0.04 0.45 0.14
16 INT229089 IL1R1 Positive_regulation of IL6 1 1 0.03 0.45 0.12
17 INT308542 Binding of AIM1 and AIM2 1 1 0.12 0 0
18 INT285231 Binding of CHKB and TNNT1 1 1 0.15 0.05 0
19 INT262413 Binding of EPHB1 and ADHD1 1 1 0.17 0.1 0
20 INT275190 Localization of CD4 Positive_regulation of Positive_regulation of LCK 1 1 0.10 0.99 0
21 INT215978 Binding of HPT and Pth 1 1 0.01 0.92 0
22 INT285232 Binding of CHKB and LDHA 1 2 0.06 0.1 0

Single Events

The table below shows the top 100 pain related interactions that have been reported in this journal. They are ordered first by their pain relevance and then by number of times they were reported in this journal. Text mining (TM) confidence, disease relevance and pain relevance are highlighted in green if they are judged to be high and red if not. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Reported in Journal Documents TM Confidence Disease Relevance Pain Relevance
1 INT2542 Localization of Calca 1 2008 0.81 518.3 1408.65
2 INT6483 Gene_expression of TNF 15 3152 0.78 2515.62 929.82
3 INT9238 Gene_expression of IL6 23 1575 0.78 1135.66 424.22
4 INT6580 Negative_regulation of Ptgs1 1 929 0.59 381.53 376.26
5 INT720 Positive_regulation of POMC 1 807 0.70 237.37 353.83
6 INT5235 Negative_regulation of TNF 3 924 0.59 772.91 331.98
7 INT5059 Positive_regulation of TNF 1 1050 0.70 896.51 322.81
8 INT6852 Localization of TNF 3 883 0.81 705.95 270.84
9 INT16868 Gene_expression of Il6 3 807 0.78 499.48 256.57
10 INT626 Localization of CALCA 1 289 0.81 125.39 221.15
11 INT6481 Binding of TNF 1 624 0.48 510.2 214.82
12 INT6482 Positive_regulation of Gene_expression of TNF 1 659 0.70 569.88 210
13 INT10194 Positive_regulation of IL6 3 702 0.70 600.62 183.38
14 INT15516 Gene_expression of Crp 2 711 0.77 615.33 173.09
15 INT9660 Regulation of TNF 2 363 0.62 312.94 139.99
16 INT1273 Gene_expression of Avp 2 356 0.78 90.56 138.7
17 INT695 Binding of POMC 1 304 0.48 56.66 126.85
18 INT17612 Gene_expression of CRP 2 676 0.78 580.61 119.03
19 INT9235 Negative_regulation of Gene_expression of TNF 1 346 0.59 252.98 118.61
20 INT12339 Localization of IL8 1 437 0.81 251.87 117.39
21 INT4207 Regulation of Avp 1 267 0.62 63.72 115.33
22 INT48593 Positive_regulation of NOS1 2 420 0.68 226.15 114.71
23 INT8413 Gene_expression of Ptgs1 1 248 0.78 110.17 108.58
24 INT12082 Localization of IL6 5 365 0.81 241.78 105.78
25 INT48767 Negative_regulation of NOS1 1 312 0.59 154.25 90.32
26 INT48408 Gene_expression of ICAM1 4 494 0.78 340.08 88.6
27 INT75999 Gene_expression of BDNF 1 344 0.78 114.19 83.12
28 INT62374 Gene_expression of NGF 2 158 0.78 77.87 76.45
29 INT1724 Negative_regulation of ACE 3 437 0.59 315.64 74.48
30 INT48244 Gene_expression of Il4 1 172 0.76 132.38 73.42
31 INT9236 Regulation of Gene_expression of TNF 3 204 0.62 162.66 72.99
32 INT11380 Negative_regulation of IL1B 1 215 0.59 125.62 72.35
33 INT6849 Localization of IL1B 1 229 0.81 112.56 69.63
34 INT8347 Gene_expression of SST 2 181 0.78 104.59 65.45
35 INT15514 Negative_regulation of Crp 2 275 0.59 194.6 64.86
36 INT9664 Binding of LBP 1 127 0.48 94.9 63.42
37 INT1169 Negative_regulation of Bche 2 322 0.59 149.22 61.27
38 INT6623 Gene_expression of NA 1 231 0.78 45.78 59.36
39 INT1759 Gene_expression of TIMP1 1 267 0.77 133.87 59.29
40 INT6477 Gene_expression of IL1RN 8 213 0.77 114.69 58.62
41 INT48901 Negative_regulation of IL6 3 186 0.57 136.33 57.87
42 INT9408 Positive_regulation of Crp 1 296 0.69 242.27 57.35
43 INT33567 Gene_expression of CALM1 1 139 0.67 48.85 56.14
44 INT52692 Gene_expression of Ptgs2 1 160 0.78 85.06 55.73
45 INT78899 Gene_expression of CCL5 2 155 0.77 84.02 55.09
46 INT251 Regulation of INS 1 398 0.62 232.47 55.04
47 INT49993 Positive_regulation of Gene_expression of Il6 2 149 0.70 88.07 53.78
48 INT5118 Regulation of SST 1 97 0.62 34.35 51.74
49 INT9210 Regulation of IL6 1 166 0.62 125.61 49.95
50 INT42980 Gene_expression of GAD1 1 139 0.69 94.77 45.11
51 INT2774 Binding of Crp 1 241 0.48 195.89 44.39
52 INT11406 Positive_regulation of Localization of CALCA 1 49 0.70 20.64 42.8
53 INT61619 Gene_expression of IL12A 1 194 0.77 146.07 41.97
54 INT13556 Gene_expression of CD4 2 367 0.78 230.82 41.74
55 INT52732 Negative_regulation of CRP 2 169 0.59 138.47 40.33
56 INT5973 Regulation of IL1B 1 109 0.62 66.6 39.88
57 INT88322 Gene_expression of CCR5 4 111 0.78 77.36 39.84
58 INT3252 Negative_regulation of INS 1 428 0.59 271.65 39.52
59 INT4449 Positive_regulation of NA 2 179 0.55 40.26 37.82
60 INT48222 Positive_regulation of Localization of IL8 1 123 0.59 78.04 37.2
61 INT9239 Regulation of Gene_expression of IL6 3 106 0.61 75.24 36.53
62 INT62827 Positive_regulation of ICAM1 1 184 0.70 180.95 36.28
63 INT8747 Positive_regulation of Ins1 1 221 0.69 154.28 35.15
64 INT79060 Gene_expression of NOS2 1 116 0.78 69.25 34.84
65 INT692 Negative_regulation of SST 1 72 0.59 28.68 34.52
66 INT16960 Gene_expression of Crp 2 166 0.76 116.21 34.07
67 INT19759 Gene_expression of LBP 1 77 0.77 56.44 33.23
68 INT10763 Localization of IL2 1 157 0.80 81.11 33.21
69 INT608 Negative_regulation of KNG1 1 98 0.43 72.36 31.23
70 INT1179 Negative_regulation of Ace 1 157 0.59 67.03 30.46
71 INT894 Binding of Avp 1 84 0.48 29.16 29.63
72 INT50230 Positive_regulation of Localization of IL6 2 105 0.70 69.21 29.52
73 INT7412 Positive_regulation of SST 1 71 0.70 24.44 29.48
74 INT86437 Binding of IL6 1 154 0.48 121.22 29.3
75 INT48853 Positive_regulation of BDNF 1 82 0.69 43.92 27.99
76 INT703 Positive_regulation of Pth 2 177 0.70 127.09 27.26
77 INT3760 Positive_regulation of ALB 1 142 0.70 87.46 26.7
78 INT130176 Positive_regulation of Gene_expression of CRP 1 125 0.66 137.06 25.9
79 INT147792 Gene_expression of COPD 2 230 0.70 287.13 24.1
80 INT17275 Gene_expression of HIVEP1 3 267 0.75 232.07 24.06
81 INT79061 Positive_regulation of NOS2 2 92 0.65 58.89 23.96
82 INT74423 Localization of IL10 1 91 0.80 61.6 22.95
83 INT8640 Positive_regulation of HSD11B1 3 332 0.67 377.84 22.36
84 INT23257 Regulation of CRP 2 127 0.62 100.05 21.87
85 INT5328 Positive_regulation of CD4 4 191 0.69 133.43 21.31
86 INT11161 Gene_expression of HLA-DRB1 1 121 0.78 75.33 20.96
87 INT78901 Localization of CCL5 2 67 0.78 40.79 20.59
88 INT125312 Positive_regulation of COPD 2 134 0.59 162.55 20.27
89 INT70970 Binding of COPD 2 144 0.42 180.34 18.29
90 INT6791 Binding of NA 2 55 0.46 5.36 17.59
91 INT29555 Positive_regulation of CALM1 1 58 0.69 14.09 17.37
92 INT6480 Positive_regulation of IL1RN 3 59 0.69 33.7 16.66
93 INT1020 Negative_regulation of BCHE 1 109 0.59 44.86 16.4
94 INT4977 Binding of ITIH4 1 60 0.46 42.48 15.65
95 INT16167 Negative_regulation of DMD 2 186 0.57 108.71 15.25
96 INT106745 Localization of CRP 1 65 0.81 66.44 15.21
97 INT12087 Regulation of Localization of TNF 1 44 0.62 28.71 15.17
98 INT16166 Positive_regulation of DMD 10 348 0.67 133.22 15.06
99 INT89293 Positive_regulation of Gene_expression of CCR5 1 29 0.70 22.14 15
100 INT505 Positive_regulation of GPT 1 89 0.67 69.38 14.94
101 INT10709 Negative_regulation of CD4 3 106 0.59 95.6 14.89
102 INT2843 Gene_expression of Epo 1 100 0.78 62.01 14.66
103 INT18012 Gene_expression of EPO 3 169 0.78 108.36 13.75
104 INT711 Positive_regulation of PIK3C2A 1 83 0.70 76.87 13.18
105 INT72565 Localization of IL1RN 1 45 0.80 23.59 13.17
106 INT20632 Gene_expression of TNC 2 72 0.78 30.43 13.16
107 INT61624 Positive_regulation of Gene_expression of IL12A 1 50 0.56 33.07 13.07
108 INT8547 Gene_expression of MUC16 1 116 0.78 75.97 12.18
109 INT110988 Gene_expression of Insr 2 58 0.42 42.12 12.18
110 INT46695 Positive_regulation of TNC 1 28 0.67 17.06 12.04
111 INT87844 Binding of IL1RN 4 40 0.41 24.37 11.92
112 INT32203 Negative_regulation of Crp 1 48 0.58 32.77 11.89
113 INT36287 Binding of CD4 1 96 0.47 58.93 11.88
114 INT4047 Binding of F13A1 1 105 0.43 66.54 11.81
115 INT1735 Gene_expression of HSD11B1 3 199 0.75 257.87 11.5
116 INT95369 Positive_regulation of Gene_expression of NOS2 1 36 0.55 25.09 11.37
117 INT8546 Positive_regulation of MUC16 1 99 0.69 74.98 11.26
118 INT67401 Gene_expression of Il12a 3 25 0.55 20.04 11.12
119 INT56448 Regulation of ICAM1 1 52 0.60 55.1 10.96
120 INT20721 Localization of ACOT1 4 47 0.80 11.37 10.95
121 INT1734 Negative_regulation of HSD11B1 4 116 0.57 125.13 10.52
122 INT6574 Negative_regulation of Pla2g1b 1 35 0.59 11.4 10.44
123 INT39712 Binding of pad 1 82 0.48 110.92 10.33
124 INT110110 Gene_expression of ACCS 1 85 0.58 75.88 10.2
125 INT80110 Regulation of Positive_regulation of TNF 1 34 0.44 25.79 9.78
126 INT80549 Binding of ICAM1 2 53 0.47 42.76 9.72
127 INT144689 Regulation of RCT 2 49 0.53 25.91 9.6
128 INT63341 Negative_regulation of ICAM1 1 42 0.59 30.45 9.5
129 INT60436 Negative_regulation of COPD 1 76 0.37 84.22 9.08
130 INT102698 Binding of ACCS 1 54 0.42 66.73 9.06
131 INT150867 Regulation of COPD 1 54 0.48 71.38 8.8
132 INT7105 Gene_expression of pad 1 54 0.77 63.68 8.8
133 INT32624 Regulation of LBP 1 15 0.60 11.48 8.71
134 INT2597 Negative_regulation of ACHE 6 82 0.59 46.36 8.62
135 INT46112 Regulation of GAD1 1 15 0.52 11.09 8.37
136 INT2280 Negative_regulation of TNFAIP1 1 70 0.43 69.43 8.36
137 INT5164 Negative_regulation of Ldlr 1 83 0.58 55.01 7.87
138 INT15918 Gene_expression of Serpine1 2 60 0.62 41.73 7.72
139 INT160440 Positive_regulation of Crem 1 48 0.69 20.38 7.66
140 INT298 Negative_regulation of ADRB3 1 23 0.59 6.82 7.56
141 INT79168 Binding of TNC 2 39 0.47 16.51 7.55
142 INT78320 Gene_expression of EPCAM 3 57 0.75 50.34 7.53
143 INT147583 Gene_expression of AIS 1 82 0.58 48.7 7.11
144 INT17049 Localization of CD4 2 57 0.75 35.33 6.89
145 INT78182 Positive_regulation of ACCS 3 43 0.43 46.39 6.78
146 INT99088 Gene_expression of HPT 1 5 0.59 9.1 6.72
147 INT24907 Gene_expression of PAPPA 4 42 0.75 28.32 6.63
148 INT50387 Negative_regulation of AR 2 67 0.45 26.31 6.61
149 INT1926 Positive_regulation of PLAT 1 54 0.66 31.42 6.49
150 INT138833 Binding of MTHFR 2 12 0.46 16.08 6.4
151 INT57256 Gene_expression of HLA-DQA2 1 52 0.55 23.87 6.27
152 INT11826 Positive_regulation of LDLR 1 62 0.62 45.09 6.21
153 INT61417 Gene_expression of ITGAL 3 36 0.75 29.62 6.15
154 INT157932 Positive_regulation of ADHD1 2 46 0.48 52.18 6.13
155 INT22128 Positive_regulation of HIVEP1 1 61 0.43 70.52 6.07
156 INT32458 Gene_expression of VWF 2 57 0.78 28.97 5.56
157 INT69350 Gene_expression of RAC1 1 23 0.77 12.16 5.54
158 INT13396 Gene_expression of DMD 2 125 0.75 57.81 5.45
159 INT118124 Binding of USE1 1 24 0.16 16.64 5.44
160 INT77281 Negative_regulation of HIVEP1 4 132 0.49 102.78 5.36
161 INT76313 Gene_expression of CD38 1 30 0.64 20.74 5.27
162 INT64723 Regulation of Positive_regulation of IL6 1 13 0.61 12.59 5.19
163 INT60252 Binding of HIVEP1 4 59 0.32 65.12 5.06
164 INT99091 Regulation of AR 1 70 0.45 31.68 5.05
165 INT74614 Positive_regulation of Apoa1 2 16 0.68 23.95 5.04
166 INT57368 Regulation of ADHD1 1 39 0.50 42.23 5.01
167 INT34870 Positive_regulation of OPA1 3 18 0.59 10.66 5
168 INT117204 Gene_expression of Tcm 1 39 0.58 10.58 4.88
169 INT16214 Localization of F13A1 2 36 0.74 21.8 4.87
170 INT51392 Negative_regulation of Insr 1 18 0.27 14.75 4.84
171 INT92199 Negative_regulation of Gene_expression of IL1RN 3 14 0.58 10.11 4.71
172 INT81485 Negative_regulation of IL1RN 1 19 0.57 8.3 4.69
173 INT87322 Binding of ITGAL 3 23 0.47 15.73 4.68
174 INT165058 Negative_regulation of MID1 1 14 0.37 10.82 4.67
175 INT5205 Localization of AR 1 43 0.80 12.87 4.63
176 INT138216 Negative_regulation of PER1 1 13 0.37 9.66 4.55
177 INT22080 Regulation of ras 1 40 0.53 36.24 4.44
178 INT35765 Gene_expression of TXNRD1 4 47 0.56 9.16 4.43
179 INT4097 Localization of Pth 2 66 0.81 47.17 4.36
180 INT162249 Gene_expression of Hist1h2aa 3 8 0.12 6.46 4.35
181 INT181596 Binding of IL1R1 2 9 0.36 7.99 4.32
182 INT116902 Positive_regulation of CD28 1 17 0.47 13.56 4.27
183 INT164220 Gene_expression of OPN1SW 1 21 0.65 13.7 4.14
184 INT168418 Positive_regulation of RCT 1 32 0.55 20.2 4.07
185 INT81688 Binding of ras 1 32 0.41 30.13 4.02
186 INT86998 Regulation of HIVEP1 2 49 0.44 37.83 4
187 INT29138 Positive_regulation of Localization of IL2 1 25 0.50 10.06 3.89
188 INT149259 Gene_expression of RCT 4 38 0.67 15.73 3.87
189 INT71374 Positive_regulation of Gene_expression of Il12a 2 5 0.22 7.49 3.8
190 INT33735 Binding of ANGPTL5 2 39 0.32 14.23 3.66
191 INT16165 Regulation of DMD 3 114 0.60 35.13 3.64
192 INT181588 Regulation of OPN1SW 1 14 0.39 8.32 3.59
193 INT536 Binding of MBP 1 17 0.48 6.52 3.56
194 INT20011 Regulation of NEUROD1 1 10 0.44 3.83 3.53
195 INT24883 Regulation of OPA1 2 14 0.45 9.73 3.44
196 INT25386 Positive_regulation of Cd3e 1 30 0.62 13.91 3.41
197 INT124123 Positive_regulation of Localization of CCL5 2 12 0.67 7 3.37
198 INT171998 Binding of DMD 1 58 0.47 38.13 3.35
199 INT148892 Binding of HPS1 1 13 0.37 19.21 3.35
200 INT6578 Regulation of Pla2g1b 1 11 0.49 3.94 3.19
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