J:World J Surg Oncol

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This page displays the top molecular interactions and top single events that were mentioned in the literature in this journal. 'Self' interactions are filtered out.

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported in this journal. They are ordered first by their pain relevance and then by number of times they were reported in this journal. Text mining (TM) confidence, disease relevance and pain relevance are highlighted in green if they are judged to be high and red if not. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Reported in Journal Documents TM Confidence Disease Relevance Pain Relevance
1 INT263917 Binding of SST and Sstr5 2 1 0.02 0.56 0.45
2 INT287697 QRFP Regulation of Gene_expression of TNF 1 1 0.40 1.23 0.42
3 INT228055 WNT1 Positive_regulation of CTNND2 1 1 0.54 1.75 0.42
4 INT328043 Binding of PTPRC and Enox2 1 1 0.00 0.88 0.34
5 INT328044 Positive_regulation of Binding of PTPRC and Enox2 1 1 0.00 0.89 0.34
6 INT328045 Binding of PTPRC and Tag 1 1 0.00 0.88 0.34
7 INT215955 Binding of alp and Cys1 1 1 0.00 0.95 0.22
8 INT326048 Gtf3a Positive_regulation of Positive_regulation of Csf2 1 1 0.04 0.5 0.16
9 INT263901 Binding of Ighg1 and Slc3a2 1 1 0.00 0.89 0.16
10 INT116124 Binding of AFP and HCC 2 1 0.20 1.72 0.15
11 INT355867 Binding of Afp and HCC 1 1 0.01 2.25 0.14
12 INT266681 TRD@ Regulation of CRP 1 1 0.06 0.5 0.13
13 INT246360 Binding of Cea and Muc6 1 1 0.00 1.09 0.12
14 INT246362 Binding of MUC2 and Cea 1 1 0.00 1.08 0.12
15 INT266683 IL1B Positive_regulation of Gene_expression of PROC 1 1 0.00 1.62 0.11
16 INT218784 Binding of TCEB2 and VHL 1 2 0.04 3.81 0.1
17 INT239643 Binding of BCL2 and BCL2L11 3 2 0.16 2.26 0.09
18 INT179872 Binding of HGF and MET 7 1 0.09 4.69 0.07
19 INT174901 Binding of GSPT2 and GTSE1 1 1 0.01 1.28 0.07
20 INT320888 Binding of olt and HCC 1 1 0.00 1.62 0.06
21 INT200212 Binding of EPAS1 and VHL 3 1 0.06 4.1 0.05
22 INT326046 Binding of Epo and Csf2 1 1 0.38 0.22 0.03
23 INT187388 Esr2 Positive_regulation of Gene_expression of Pgr 1 1 0.00 0.8 0.03
24 INT244656 Binding of S100B and SLC4A1 1 1 0.14 1.72 0.03
25 INT326045 Epo Positive_regulation of Mki67 1 1 0.16 0.18 0.03
26 INT326051 Csf2 Positive_regulation of PCNA 1 1 0.04 0.17 0.03
27 INT326050 Csf2 Positive_regulation of Mki67 1 1 0.15 0.18 0.03
28 INT326052 Epo Positive_regulation of PCNA 1 1 0.04 0.17 0.03
29 INT290556 Binding of MLH1 and MSH2 3 2 0.34 2.74 0
30 INT211335 Binding of MET and MKI67 1 1 0.02 1.6 0
31 INT211336 Binding of MKI67 and VEGFA 1 3 0.08 4.94 0
32 INT211333 Binding of HGF and MKI67 1 1 0.04 1.6 0
33 INT326047 Csf2 Regulation of Epo 1 2 0.29 0.22 0
34 INT234612 Binding of KIT and STIP1 1 1 0.04 1 0
35 INT341631 EGFR Positive_regulation of TXK 1 1 0.05 0.42 0
36 INT263900 Binding of Col1a1 and Cea 1 1 0.01 0.63 0
37 INT326049 Csf2 Negative_regulation of Epo 1 1 0.46 0.25 0
38 INT211334 Binding of HGF and VEGFA 1 3 0.23 4.89 0
39 INT266682 TRD@ Negative_regulation of TNF 1 1 0.12 1.55 0
40 INT282743 Hsp90aa1 Positive_regulation of Kit 1 1 0.22 0.54 0
41 INT263918 Binding of PTPRC and Cea 1 1 0.00 0.37 0
42 INT347035 Binding of Kit and Cd34 1 1 0.02 1.38 0
43 INT233771 Binding of KRT7 and KRT20 1 1 0.01 1.72 0
44 INT239602 Binding of CSF2 and VIM 1 1 0.16 1.44 0
45 INT324908 TP53 Regulation of Gene_expression of BAX 1 1 0.47 1.33 0
46 INT183721 HPN Positive_regulation of MYO7A 1 1 0.02 1.55 0
47 INT263899 Binding of PTPRC and TMED7-TICAM2 1 1 0.00 0.85 0
48 INT218785 Binding of FN1 and VHL 1 1 0.06 1.12 0
49 INT320887 Binding of TP63 and olt 1 1 0.01 2.15 0
50 INT324909 Negative_regulation of TP53 Positive_regulation of Negative_regulation of BAX 1 1 0.36 1.33 0
51 INT341632 Binding of EGFR and FOXM1 1 1 0.02 0.56 0
52 INT233777 Binding of KRT20 and Cea 1 2 0.01 3.42 0

Single Events

The table below shows the top 100 pain related interactions that have been reported in this journal. They are ordered first by their pain relevance and then by number of times they were reported in this journal. Text mining (TM) confidence, disease relevance and pain relevance are highlighted in green if they are judged to be high and red if not. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Reported in Journal Documents TM Confidence Disease Relevance Pain Relevance
1 INT6483 Gene_expression of TNF 3 3152 0.78 2515.62 929.82
2 INT1912 Gene_expression of Calca 3 1152 0.78 453.25 739.84
3 INT9238 Gene_expression of IL6 2 1575 0.78 1135.66 424.22
4 INT720 Positive_regulation of POMC 2 807 0.70 237.37 353.83
5 INT6852 Localization of TNF 5 883 0.81 705.95 270.84
6 INT10832 Gene_expression of IL8 3 1050 0.78 698.72 270
7 INT5972 Gene_expression of IL1B 6 948 0.78 510.91 263.97
8 INT68684 Gene_expression of VEGFA 13 2371 0.78 1742.52 259.2
9 INT16868 Gene_expression of Il6 1 807 0.78 499.48 256.57
10 INT2391 Negative_regulation of PTGS1 1 501 0.59 207.62 205.6
11 INT15516 Gene_expression of Crp 1 711 0.77 615.33 173.09
12 INT2640 Gene_expression of Pomc 15 424 0.78 120.72 155.37
13 INT15515 Positive_regulation of Crp 7 700 0.70 604.24 150.15
14 INT9852 Positive_regulation of Gpt 3 563 0.70 364.64 146.82
15 INT14151 Gene_expression of Casp3 2 311 0.78 140.26 120.68
16 INT17612 Gene_expression of CRP 1 676 0.78 580.61 119.03
17 INT5010 Gene_expression of Calca 1 197 0.78 85.76 118.75
18 INT9235 Negative_regulation of Gene_expression of TNF 1 346 0.59 252.98 118.61
19 INT1438 Localization of Pomc 2 360 0.81 101.26 116.47
20 INT3038 Gene_expression of INS 1 1583 0.78 1174.16 107.01
21 INT12082 Localization of IL6 3 365 0.81 241.78 105.78
22 INT18009 Positive_regulation of CRP 4 518 0.70 553.03 103.74
23 INT90091 Gene_expression of GOPC 1 967 0.67 366.22 103.6
24 INT11587 Gene_expression of CSF2 51 645 0.78 544.38 93.89
25 INT48406 Gene_expression of Icam1 1 277 0.78 238.28 81.71
26 INT3214 Localization of Ins1 1 527 0.80 196.9 79.26
27 INT11380 Negative_regulation of IL1B 3 215 0.59 125.62 72.35
28 INT10837 Positive_regulation of Gene_expression of IL8 1 294 0.70 190.08 70.34
29 INT79494 Positive_regulation of Gene_expression of VEGFA 2 577 0.70 442.94 69.73
30 INT6849 Localization of IL1B 1 229 0.81 112.56 69.63
31 INT19511 Localization of Il6 3 212 0.81 118.17 67.67
32 INT5374 Gene_expression of Esr1 8 412 0.77 263.89 67.34
33 INT4960 Positive_regulation of CSF2 12 285 0.70 256.73 65.73
34 INT8347 Gene_expression of SST 4 181 0.78 104.59 65.45
35 INT822 Gene_expression of ESR1 6 529 0.78 302.16 63.64
36 INT17564 Gene_expression of Gpt 2 322 0.75 208.51 60.36
37 INT9408 Positive_regulation of Crp 3 296 0.69 242.27 57.35
38 INT82650 Gene_expression of Bcl2 2 312 0.78 211.71 55.03
39 INT22112 Positive_regulation of Localization of TNF 2 164 0.70 115.66 52.18
40 INT6473 Positive_regulation of Gene_expression of IL1B 1 204 0.70 117.23 50.86
41 INT4345 Gene_expression of Gtf3a 1 157 0.67 80.75 48.47
42 INT17881 Gene_expression of LEP 2 278 0.78 221.61 48.31
43 INT671 Positive_regulation of Cea 10 221 0.69 164.5 47.79
44 INT16364 Gene_expression of HLA-DRA 1 234 0.78 118.81 45.01
45 INT3361 Positive_regulation of Esr1 1 273 0.69 208.53 44.81
46 INT27493 Negative_regulation of Casp3 3 114 0.56 56.89 44.63
47 INT80124 Negative_regulation of VEGFA 2 450 0.58 311.19 44.53
48 INT89 Positive_regulation of Gast 1 187 0.70 80.49 42.07
49 INT2364 Localization of Sct 1 134 0.80 26.21 41.47
50 INT30 Gene_expression of Gast 2 158 0.78 99 41.45
51 INT52732 Negative_regulation of CRP 1 169 0.59 138.47 40.33
52 INT3758 Gene_expression of ALB 3 326 0.78 184.65 38.75
53 INT16323 Gene_expression of pr 4 62 0.66 36.14 38.26
54 INT11439 Positive_regulation of Csf2 3 105 0.69 62.63 37.77
55 INT63349 Gene_expression of PECAM1 1 199 0.75 166.03 36.76
56 INT9082 Positive_regulation of ESR1 1 238 0.69 148.51 36.69
57 INT101992 Localization of VEGFA 4 413 0.81 258.23 36.15
58 INT5743 Localization of NA 1 104 0.59 14.35 35.29
59 INT6484 Binding of IL1B 1 122 0.47 75.84 35.07
60 INT129686 Gene_expression of FSCN1 1 46 0.15 18.91 34.47
61 INT1624 Gene_expression of Cea 30 212 0.76 180.44 34.21
62 INT53475 Gene_expression of MRI1 3 116 0.59 77.68 33.98
63 INT234 Binding of Alb 1 151 0.48 52.34 32.97
64 INT10248 Gene_expression of KRT20 23 436 0.78 231.96 32.88
65 INT691 Binding of SST 1 67 0.48 24.66 32.67
66 INT14823 Gene_expression of MET 1 103 0.75 51.92 32.48
67 INT22939 Gene_expression of Csf2 1 164 0.78 85.1 32.22
68 INT65960 Gene_expression of BCL2 35 352 0.78 312.03 30.73
69 INT50230 Positive_regulation of Localization of IL6 2 105 0.70 69.21 29.52
70 INT660 Negative_regulation of REN 1 194 0.59 82.06 29.46
71 INT28361 Gene_expression of TP53 17 443 0.78 384.86 28.8
72 INT8097 Gene_expression of EGF 2 122 0.77 75.94 28.47
73 INT6624 Gene_expression of Pth 1 135 0.76 110.27 27.54
74 INT703 Positive_regulation of Pth 3 177 0.70 127.09 27.26
75 INT14690 Localization of CSF2 3 124 0.80 85.17 27.26
76 INT9647 Gene_expression of PROC 5 163 0.65 89.76 26.75
77 INT17739 Gene_expression of S100B 10 226 0.78 132.7 26.4
78 INT20462 Binding of ESR1 2 210 0.44 102.7 26.34
79 INT62710 Gene_expression of HGF 2 160 0.78 88.27 26.14
80 INT11159 Gene_expression of EGFR 13 698 0.78 548.93 25.69
81 INT122570 Negative_regulation of Akt1 1 173 0.59 91.44 25.53
82 INT4877 Gene_expression of MME 2 184 0.78 122.82 24.78
83 INT2614 Gene_expression of CGA 1 187 0.78 105.89 24.77
84 INT22708 Gene_expression of MUC1 9 297 0.78 232.71 24.19
85 INT18323 Negative_regulation of Localization of Ins1 1 122 0.58 45.74 23.04
86 INT29704 Regulation of Casp3 2 51 0.56 22.13 22.79
87 INT91891 Gene_expression of Kit 44 268 0.78 158.89 22.67
88 INT823 Negative_regulation of ESR1 2 144 0.58 63.72 22.52
89 INT2386 Gene_expression of Pgr 3 112 0.78 45.46 22.19
90 INT48407 Positive_regulation of Gene_expression of Icam1 1 61 0.70 57.91 21.54
91 INT73593 Gene_expression of BAX 6 173 0.76 147.81 20.94
92 INT3593 Gene_expression of ADRA1D 1 70 0.75 29.48 20.87
93 INT106097 Localization of pr 1 20 0.62 12.01 19.46
94 INT18311 Positive_regulation of CD8A 1 145 0.69 113.48 19.44
95 INT16445 Gene_expression of IL1A 1 60 0.78 44.46 19.19
96 INT712 Positive_regulation of LDHA 1 160 0.70 175.25 19.11
97 INT69592 Positive_regulation of PSMD1 1 27 0.70 17.83 18.98
98 INT56749 Gene_expression of PCNA 12 219 0.77 111.25 18.42
99 INT3952 Negative_regulation of ALB 2 116 0.59 72.18 18.35
100 INT15148 Gene_expression of Vip 2 51 0.77 25.61 18.33
101 INT28215 Gene_expression of CDKN1A 4 196 0.76 113.9 18.3
102 INT6782 Gene_expression of SCN5A 1 156 0.78 33.13 17.88
103 INT4067 Negative_regulation of Esr1 1 97 0.50 43.45 17.52
104 INT68681 Transcription of VEGFA 1 132 0.71 80.47 17.03
105 INT1767 Positive_regulation of PROC 1 83 0.67 54.14 17
106 INT13510 Gene_expression of ERBB2 3 530 0.78 405.68 16.79
107 INT65856 Positive_regulation of TP53 1 138 0.67 112.65 16.71
108 INT2432 Positive_regulation of Cp 1 41 0.67 31.1 16.68
109 INT93361 Gene_expression of Trp53 2 208 0.78 175.35 16.65
110 INT5841 Gene_expression of Vim 13 181 0.72 138.54 16.33
111 INT10214 Gene_expression of VIM 8 153 0.78 115.88 16.29
112 INT899 Gene_expression of F13A1 4 122 0.70 78.02 16.26
113 INT1261 Localization of Adh1 1 63 0.81 19.36 16.09
114 INT8571 Gene_expression of B3GAT1 1 54 0.75 36.85 15.98
115 INT9783 Gene_expression of INSRR 4 81 0.50 32.99 15.52
116 INT170855 Negative_regulation of GOPC 2 188 0.38 70.92 15.41
117 INT10709 Negative_regulation of CD4 1 106 0.59 95.6 14.89
118 INT2843 Gene_expression of Epo 8 100 0.78 62.01 14.66
119 INT20611 Gene_expression of Asap1 1 55 0.65 23.71 14.62
120 INT11340 Positive_regulation of SLC17A5 2 120 0.67 113.52 14.5
121 INT22301 Positive_regulation of Gene_expression of CSF2 3 66 0.63 59.49 14.24
122 INT37722 Gene_expression of NCAM1 4 103 0.75 81.57 14.18
123 INT59870 Gene_expression of F3 2 51 0.65 51.83 14.01
124 INT27739 Positive_regulation of EGF 1 49 0.70 28.31 13.68
125 INT78472 Gene_expression of CDKN2A 11 223 0.78 173.76 13.61
126 INT86383 Negative_regulation of EGFR 2 258 0.59 173.94 13.32
127 INT20632 Gene_expression of TNC 2 72 0.78 30.43 13.16
128 INT27242 Gene_expression of PGR 1 153 0.75 98.77 12.79
129 INT55255 Positive_regulation of Localization of Il6 2 48 0.69 24.88 12.76
130 INT3521 Regulation of Csf2 2 38 0.54 11.09 12.73
131 INT89395 Negative_regulation of AKT1 1 127 0.58 70.27 12.54
132 INT24876 Gene_expression of CD34 16 172 0.78 91.02 12.39
133 INT8224 Gene_expression of CHGA 9 73 0.75 53.63 12.31
134 INT8547 Gene_expression of MUC16 3 116 0.78 75.97 12.18
135 INT79545 Positive_regulation of Gene_expression of ESR1 2 82 0.64 39.42 12.18
136 INT4047 Binding of F13A1 1 105 0.43 66.54 11.81
137 INT28872 Positive_regulation of CSRP1 1 49 0.70 47.23 11.7
138 INT21632 Positive_regulation of Adh1 1 32 0.70 15.67 11.65
139 INT111476 Gene_expression of TP63 3 88 0.76 61.08 11.64
140 INT69029 Gene_expression of PTPRC 2 127 0.75 74.26 11.57
141 INT19795 Positive_regulation of EGFR 9 161 0.70 103.69 11.55
142 INT82684 Positive_regulation of Pecam1 1 27 0.49 25.67 11.47
143 INT661 Gene_expression of REN 1 100 0.78 48.21 11.36
144 INT8546 Positive_regulation of MUC16 3 99 0.69 74.98 11.26
145 INT25963 Gene_expression of DES 8 122 0.75 98.81 11.25
146 INT3845 Gene_expression of GSR 1 79 0.76 44.69 11.19
147 INT13240 Gene_expression of TF 2 94 0.76 57.81 10.99
148 INT2491 Regulation of Cea 1 38 0.61 26.18 10.95
149 INT15350 Localization of Prl 2 22 0.81 6.86 10.74
150 INT15054 Gene_expression of Mme 1 48 0.77 42.52 10.63
151 INT27651 Gene_expression of S100A12 1 45 0.76 52.25 10.51
152 INT15888 Positive_regulation of Nbr1 1 42 0.69 35.76 10.48
153 INT24166 Localization of Mln 1 40 0.80 9.11 10.32
154 INT2792 Gene_expression of Mb 1 91 0.76 41.56 10.25
155 INT35164 Negative_regulation of IGHE 1 96 0.58 76.3 9.74
156 INT2036 Localization of EGF 1 42 0.77 21.5 9.74
157 INT62166 Positive_regulation of Gene_expression of Gpt 1 64 0.50 39.13 9.69
158 INT10139 Positive_regulation of F13A1 1 64 0.56 44.75 9.69
159 INT70134 Negative_regulation of TXK 2 124 0.23 81.96 9.59
160 INT73596 Positive_regulation of Gene_expression of BAX 1 43 0.67 40.97 9.22
161 INT6510 Gene_expression of AFP 45 130 0.78 119.2 9.19
162 INT285 Positive_regulation of Salpa1 1 73 0.68 61.47 9.19
163 INT64346 Positive_regulation of S100B 4 95 0.70 63.11 9.17
164 INT2139 Negative_regulation of Cea 3 55 0.43 43.59 9.14
165 INT64849 Gene_expression of Ret 1 24 0.75 14.36 9.1
166 INT80037 Gene_expression of BAK1 4 58 0.75 39.49 9.08
167 INT8632 Regulation of Nfasc 1 15 0.54 2.87 9.08
168 INT9548 Gene_expression of CHKB 2 99 0.65 50.86 9.03
169 INT82685 Gene_expression of Pecam1 2 36 0.76 27.95 9.01
170 INT128159 Positive_regulation of DDIT3 1 29 0.67 29.5 8.99
171 INT14301 Binding of CSF2 2 82 0.48 67.95 8.98
172 INT158796 Positive_regulation of SMUG1 4 67 0.70 38.97 8.98
173 INT69264 Gene_expression of KIT 47 207 0.78 179.41 8.95
174 INT80420 Gene_expression of IFI27 3 145 0.78 63.61 8.83
175 INT57057 Gene_expression of APC 1 131 0.78 122.24 8.7
176 INT70017 Positive_regulation of BCL2 1 87 0.67 66.62 8.68
177 INT144430 Gene_expression of Erbb2 2 137 0.77 103.87 8.66
178 INT70896 Gene_expression of PDGFB 1 48 0.65 33.55 8.39
179 INT6810 Gene_expression of ENO2 1 70 0.78 54.8 8.35
180 INT4991 Positive_regulation of Vim 5 74 0.69 69.84 8.33
181 INT156827 Localization of MRI1 1 25 0.65 16.06 8.33
182 INT65959 Positive_regulation of Gene_expression of BCL2 3 75 0.70 77.3 8.27
183 INT36798 Gene_expression of Mki67 8 178 0.77 132 8.24
184 INT6625 Negative_regulation of Pth 1 96 0.58 57.6 8.24
185 INT6557 Gene_expression of Eno2 3 65 0.77 54.42 8.17
186 INT13539 Gene_expression of LTA 1 39 0.62 22.55 8.07
187 INT2093 Gene_expression of GAST 1 50 0.78 32.32 7.98
188 INT84894 Gene_expression of Calb2 3 45 0.73 24.65 7.81
189 INT111607 Gene_expression of CDH1 6 103 0.75 90.45 7.77
190 INT167052 Gene_expression of Cr2 2 43 0.56 25.7 7.76
191 INT162393 Gene_expression of SMUG1 1 58 0.75 38.78 7.7
192 INT8669 Positive_regulation of Afp 1 66 0.70 58.21 7.67
193 INT16869 Positive_regulation of Prl 1 24 0.70 15.7 7.63
194 INT74520 Positive_regulation of CD68 2 30 0.61 31.68 7.59
195 INT24891 Gene_expression of SYP 6 55 0.75 45.76 7.53
196 INT57748 Positive_regulation of Gene_expression of TP53 4 85 0.69 79.55 7.49
197 INT182440 Gene_expression of CCNE2 1 39 0.53 22.07 7.44
198 INT121496 Gene_expression of TERT 5 107 0.78 45.6 7.42
199 INT169435 Gene_expression of CHPT1 1 17 0.61 10.04 7.37
200 INT15887 Gene_expression of Nbr1 1 39 0.77 23.91 7.34
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