P:Abstinence syndrome

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Pain Term
Category Condition
Synonyms None
Pain Specific No
Documents 434
Hot Single Events 55
Hot Interactions 0

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported for Abstinence syndrome. They are ordered first by their pain relevance and then by number of times they were reported for Abstinence syndrome. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT257895 Positive_regulation of Sostdc1 Positive_regulation of Positive_regulation of GRIN1 1 0.00 0.09 0.83 5.00
2 INT257896 Sostdc1 Positive_regulation of Positive_regulation of GRIN1 1 0.00 0.09 0.83 5.00
3 INT321045 Anpep Positive_regulation of Protein_catabolism of Ptpn6 1 0.01 0.22 0.48 5.00
4 INT321046 Anpep Regulation of Negative_regulation of Hps4 1 0.02 0.25 0.43 5.00
5 INT321047 Anpep Regulation of Negative_regulation of Ptpn6 1 0.01 0.25 0.43 5.00
6 INT350736 PRKDC Negative_regulation of CA2 1 0.02 0.16 0.11 5.00
7 INT350735 PRKDC Negative_regulation of ITPR3 1 0.01 0.16 0.11 5.00
8 INT275064 Binding of CA2 and CALM1 2 0.06 0 0.07 5.00
9 INT350737 Binding of CALM1 and ETF1 1 0.00 0 0.04 5.00

Single Events

The table below shows the top 200 pain related interactions that have been reported for Abstinence syndrome. They are ordered first by their pain relevance and then by number of times they were reported in Abstinence syndrome. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT63601 Regulation of Bok 1 0.05 0.17 0.97 99.80
2 INT18489 Binding of Man2a2 59 0.48 11.27 29.38 99.60
3 INT4957 Negative_regulation of Grin1 87 0.59 24.51 53.21 99.04
4 INT51723 Regulation of HELLS 2 0.30 1.03 0.75 98.96
5 INT21527 Gene_expression of FosB 47 0.78 11.2 34.39 98.80
6 INT403 Localization of Trh 241 0.81 28.55 81.45 98.80
7 INT99076 Regulation of Gene_expression of FosB 7 0.62 1.34 7.32 98.80
8 INT10285 Binding of ADRA1D 102 0.47 25.82 31.11 98.52
9 INT9895 Binding of GHR 18 0.36 4.8 5.65 98.52
10 INT12412 Binding of MPG 21 0.47 3.92 4.94 98.52
11 INT121912 Negative_regulation of Insl6 1 0.41 0.17 0.32 97.92
12 INT83682 Positive_regulation of Abcb1a 22 0.68 3.3 15.6 97.88
13 INT11439 Positive_regulation of Csf2 105 0.69 62.63 37.77 97.84
14 INT22374 Positive_regulation of Regulation of E2f8 1 0.09 0.17 0.47 97.84
15 INT1486 Negative_regulation of Cpe 85 0.59 28.78 54.08 97.80
16 INT239222 Positive_regulation of Gene_expression of Agtrap 10 0.57 7.54 0.83 97.48
17 INT239217 Gene_expression of Agtrap 47 0.78 48.8 4.44 97.48
18 INT22373 Regulation of E2f8 2 0.05 0.25 0.58 97.44
19 INT22897 Positive_regulation of Tmprss11d 1 0.49 0.4 1.07 97.30
20 INT51724 Localization of HELLS 2 0.49 1.02 0.81 96.84
21 INT51722 Positive_regulation of Localization of HELLS 1 0.05 0.37 0.76 96.84
22 INT5061 Negative_regulation of Mme 306 0.59 51.97 136.9 96.80
23 INT2211 Negative_regulation of Abat 267 0.59 66.51 200.98 96.12
24 INT36502 Positive_regulation of asp1 10 0.40 6.26 4.45 96.12
25 INT1375 Negative_regulation of Pde4dl1 13 0.57 5.54 4.63 95.68
26 INT1396 Binding of Penk 355 0.48 22.79 269.65 95.44
27 INT5871 Binding of IFNA2 38 0.48 20.35 6.46 95.08
28 INT6406 Binding of Oprm1 280 0.48 40.54 226.26 94.32
29 INT71314 Regulation of Ptges3 1 0.13 0.84 1.02 91.92
30 INT1303 Negative_regulation of Npr1 278 0.55 35.1 156.78 91.08
31 INT67862 Negative_regulation of ETF1 3 0.29 1.45 1.91 91.04
32 INT867 Gene_expression of IFNA1 930 0.78 594.85 168.03 90.88
33 INT1139 Gene_expression of IgG-2a 35 0.65 19.19 12 90.76
34 INT2802 Negative_regulation of Asrgl1 14 0.59 2.69 7.37 90.72
35 INT7776 Gene_expression of Abcb1b 63 0.75 21.35 14.92 90.36
36 INT1352 Localization of Acot1 728 0.80 73.01 296.01 90.08
37 INT21532 Negative_regulation of Gene_expression of Il2 47 0.59 20.43 16.96 90.04
38 INT55886 Negative_regulation of Gene_expression of Il4 47 0.57 26.04 11.42 90.04
39 INT90300 Gene_expression of Abcb1a 56 0.78 11.05 22.89 89.72
40 INT5513 Negative_regulation of Pomc 295 0.59 60.9 158.63 88.08
41 INT101483 Gene_expression of Lep 159 0.78 104.77 25.12 87.92
42 INT4842 Regulation of Npff 13 0.54 4.59 13.62 87.60
43 INT12501 Positive_regulation of Adarb1 166 0.58 36.94 118.92 87.52
44 INT18616 Positive_regulation of Positive_regulation of Adarb1 18 0.33 2.04 13.18 87.52
45 INT11807 Gene_expression of Il2 266 0.78 112 64.97 87.04
46 INT121911 Regulation of Insl6 1 0.43 0.16 0.31 86.72
47 INT1212 Binding of Oprl1 312 0.48 28.6 225.15 86.16
48 INT20374 Gene_expression of Il4 515 0.76 306.15 114.12 86.04
49 INT5957 Positive_regulation of Cpe 65 0.69 21.07 51.22 84.16
50 INT22517 Gene_expression of Mop3 5 0.03 0.18 3.43 83.04
51 INT1614 Gene_expression of Oprl1 164 0.78 31.43 127.74 83.00
52 INT4841 Localization of Npff 26 0.80 4.36 19.91 82.88
53 INT15459 Gene_expression of TRH 17 0.78 4.89 8.17 82.24
54 INT32210 Gene_expression of Mif 13 0.75 28.48 7.79 82.04
55 INT101482 Negative_regulation of Lep 53 0.54 33.59 5.65 80.56
56 INT52457 Gene_expression of ABCB1 129 0.78 38.68 19.88 79.52
57 INT123712 Gene_expression of SLC22A18 1 0.69 0 0.92 79.52
58 INT21662 Gene_expression of Cpz 4 0.51 1.14 3.36 79.12
59 INT3535 Regulation of CA2 61 0.32 16.48 10.8 78.68
60 INT53959 Negative_regulation of Npff 6 0.57 0.55 4.86 78.36
61 INT13244 Binding of Helt 30 0.31 4.56 18.01 78.24
62 INT167270 Negative_regulation of Gene_expression of Lep 13 0.55 5.48 1.19 77.24
63 INT66416 Regulation of Pnoc 66 0.61 17.32 68.91 77.04
64 INT56389 Gene_expression of S100a1 4 0.54 0.69 1.01 75.20
65 INT1395 Negative_regulation of Penk 537 0.59 87.33 389.81 75.12
66 INT137811 Negative_regulation of NGFR 4 0.50 2.22 1.28 75.12
67 INT16155 Positive_regulation of Npff 25 0.70 6.21 17.58 75.00
68 INT22898 Negative_regulation of Gls 2 0.45 1.52 3.19 75.00
69 INT156 Negative_regulation of Prl 542 0.59 131.97 192.24 75.00
70 INT8963 Gene_expression of Trh 25 0.68 7.5 10.97 75.00
71 INT8966 Regulation of Trh 12 0.62 2.73 10.79 75.00
72 INT75562 Regulation of FosB 8 0.52 2.38 4.07 75.00
73 INT90727 Negative_regulation of Gene_expression of FosB 4 0.54 0.5 3.37 75.00
74 INT73362 Negative_regulation of Abcb1a 46 0.59 8.78 17.81 74.88
75 INT82572 Negative_regulation of Prkg2 4 0.14 0.82 3.03 71.28
76 INT6483 Gene_expression of TNF 3152 0.78 2515.62 929.82 68.56
77 INT40160 Positive_regulation of Adora1 74 0.70 26.36 33.03 67.20
78 INT1463 Binding of Pomc 129 0.48 15.89 56.27 64.24
79 INT5931 Regulation of Oprm1 149 0.62 18.15 125.93 63.64
80 INT18261 Positive_regulation of Baa1 1 0.04 0.52 0.43 63.16
81 INT19408 Negative_regulation of Cyp2c22 37 0.59 6.23 14.22 62.24
82 INT28001 Gene_expression of Gpm6a 23 0.66 16.66 21.09 61.20
83 INT114 Binding of Oprl1 139 0.48 23 103.35 59.92
84 INT1376 Binding of Trh 121 0.48 20 69.86 59.72
85 INT70801 Gene_expression of Hmgcr 12 0.42 3.08 4.1 57.52
86 INT9157 Negative_regulation of Negative_regulation of Penk 13 0.43 2.3 9.54 56.32
87 INT4613 Positive_regulation of Sirt1 32 0.67 18.19 5.53 55.60
88 INT5228 Positive_regulation of Fos 934 0.70 209.8 503.87 54.96
89 INT546 Binding of ALB 311 0.48 85.98 60.14 54.04
90 INT7703 Gene_expression of Gls 2 0.22 0.58 0.47 53.68
91 INT18736 Gene_expression of Ptpn6 19 0.59 4.44 8.06 53.40
92 INT9491 Positive_regulation of Ptpn6 11 0.51 2.33 7.32 53.40
93 INT321016 Regulation of Positive_regulation of Ptpn6 1 0.05 0.05 1.15 53.40
94 INT314388 Positive_regulation of Gene_expression of Ptpn6 3 0.11 0.05 1.15 53.40
95 INT6717 Negative_regulation of YY1 45 0.57 15.35 27.8 53.16
96 INT7702 Gene_expression of Asrgl1 5 0.77 3.33 0.89 52.40
97 INT321020 Regulation of Protein_catabolism of Ptpn6 1 0.06 0.05 1.12 52.28
98 INT5501 Regulation of Oprd1 283 0.62 55.1 249.9 51.84
99 INT6116 Regulation of Gene_expression of Oprd1 69 0.62 16.43 54 51.84
100 INT7076 Regulation of Serbp1 11 0.45 0.96 8.12 51.84
101 INT321018 Protein_catabolism of Ptpn6 1 0.14 0.52 2.73 51.64
102 INT5979 Gene_expression of Oprd1 428 0.78 75.64 320.32 51.40
103 INT234 Binding of Alb 151 0.48 52.34 32.97 50.00
104 INT615 Regulation of Alb 66 0.62 33.43 15.33 50.00
105 INT89271 Gene_expression of Serbp1 4 0.52 1.41 4.53 48.60
106 INT13400 Negative_regulation of Enpep 30 0.50 4.23 15.86 45.36
107 INT10796 Gene_expression of CYP2B6 131 0.77 30.14 35.27 45.20
108 INT4781 Gene_expression of TH 68 0.73 26.92 24.01 42.16
109 INT41728 Gene_expression of CHAT 65 0.75 42.19 12.73 42.16
110 INT28662 Gene_expression of PON1 19 0.65 16.46 4.49 42.16
111 INT21661 Regulation of Negative_regulation of Gls2 1 0.02 0.26 0.6 41.44
112 INT21664 Negative_regulation of Gls2 1 0.02 0.26 0.6 41.44
113 INT21663 Regulation of Negative_regulation of Asrgl1 1 0.03 0.21 0.6 40.00
114 INT47052 Negative_regulation of Dpp3 1 0.06 0 0.98 39.20
115 INT5200 Gene_expression of Fos 3083 0.78 894.43 1639.02 39.12
116 INT5591 Regulation of Gene_expression of Fos 425 0.62 129.06 265.78 39.12
117 INT5660 Binding of Oprd1 477 0.48 71.86 342.06 38.00
118 INT5587 Regulation of Fos 191 0.62 40.81 99.7 37.12
119 INT6669 Negative_regulation of Positive_regulation of Fos 98 0.59 23.5 56.82 37.12
120 INT19949 Regulation of Positive_regulation of Fos 36 0.60 6.11 22.05 37.12
121 INT3506 Localization of TH 12 0.81 0.78 6.66 35.68
122 INT47386 Negative_regulation of CHAT 5 0.29 1.63 2.61 35.68
123 INT15765 Localization of PON1 8 0.75 3.61 2.08 35.68
124 INT208789 Negative_regulation of Localization of TH 2 0.25 0 0.89 35.68
125 INT193070 Localization of CHAT 3 0.17 1.03 0.86 35.68
126 INT6436 Positive_regulation of Positive_regulation of Fos 101 0.70 18.71 57.96 35.52
127 INT3128 Negative_regulation of PON1 30 0.59 26.19 4.57 33.52
128 INT122896 Negative_regulation of TH 23 0.57 9.27 6.88 31.60
129 INT1179 Negative_regulation of Ace 157 0.59 67.03 30.46 25.00
130 INT197458 Positive_regulation of Sostdc1 11 0.01 3.02 4.87 24.96
131 INT6214 Negative_regulation of Adarb1 123 0.50 26.39 89.57 18.48
132 INT654 Localization of REN 250 0.81 75.12 47.86 13.52
133 INT14049 Positive_regulation of GRIN1 102 0.70 48.31 71.06 12.00
134 INT54284 Negative_regulation of Gene_expression of Oprd1 16 0.42 4.56 14.34 6.68
135 INT274750 Gene_expression of Mpeg1 4 0.55 6.1 1.3 5.36
136 INT720 Positive_regulation of POMC 807 0.70 237.37 353.83 5.00
137 INT2391 Negative_regulation of PTGS1 501 0.59 207.62 205.6 5.00
138 INT4937 Negative_regulation of Oprd1 224 0.59 44.51 171.11 5.00
139 INT49134 Gene_expression of Grin1 270 0.78 84.78 148.61 5.00
140 INT7341 Positive_regulation of Grin1 169 0.70 65.86 118.38 5.00
141 INT3537 Positive_regulation of Car2 413 0.56 103.51 94.35 5.00
142 INT96917 Positive_regulation of Mapk14 261 0.70 173.29 88.79 5.00
143 INT7028 Localization of Pdyn 90 0.81 8.89 73.54 5.00
144 INT8346 Gene_expression of Qrfp 136 0.70 19.49 70.21 5.00
145 INT4637 Binding of Adarb1 132 0.41 14.48 67.76 5.00
146 INT24989 Positive_regulation of Cfp 125 0.61 29.55 64.9 5.00
147 INT8733 Localization of Oprm1 61 0.75 7.55 64.61 5.00
148 INT6623 Gene_expression of NA 231 0.78 45.78 59.36 5.00
149 INT63975 Positive_regulation of Il10 175 0.68 134.13 54.69 5.00
150 INT52611 Negative_regulation of Ptgs2 142 0.59 66.31 52.71 5.00
151 INT7093 Negative_regulation of CYP2B6 146 0.58 37.3 48.39 5.00
152 INT375 Positive_regulation of REN 293 0.70 152.46 47.55 5.00
153 INT30170 Gene_expression of Car2 330 0.66 77.26 46.76 5.00
154 INT6979 Positive_regulation of CA2 206 0.67 50.79 44.97 5.00
155 INT17561 Localization of Car2 303 0.79 60.95 44.52 5.00
156 INT11246 Binding of Grin1 65 0.48 14.53 36.93 5.00
157 INT5489 Localization of CA2 172 0.80 39.46 33.56 5.00
158 INT45365 Negative_regulation of Cfp 68 0.57 25.44 32.11 5.00
159 INT12502 Regulation of Adarb1 50 0.53 7.58 30.01 5.00
160 INT32165 Binding of CALM1 92 0.48 24.19 29.57 5.00
161 INT67912 Gene_expression of GRIN1 75 0.77 28.99 29.28 5.00
162 INT12129 Gene_expression of CYP3A4 107 0.78 23.11 27.6 5.00
163 INT80470 Negative_regulation of Gene_expression of Grin1 33 0.59 10.22 27.15 5.00
164 INT1728 Negative_regulation of Cndp2 36 0.57 3.76 25.39 5.00
165 INT48766 Regulation of NOS1 73 0.61 37.01 24.59 5.00
166 INT5690 Negative_regulation of Binding of Oprd1 36 0.59 8.29 24.52 5.00
167 INT2140 Regulation of REN 104 0.62 28.24 24.49 5.00
168 INT17962 Regulation of Car2 124 0.41 33.98 22.71 5.00
169 INT62373 Negative_regulation of NGF 34 0.59 25.87 22.38 5.00
170 INT56461 Localization of Vta1 23 0.59 2.03 20.74 5.00
171 INT7581 Binding of ADHD1 132 0.46 135.1 19.73 5.00
172 INT3060 Negative_regulation of Bche 94 0.59 46.75 18.51 5.00
173 INT31905 Positive_regulation of Binding of Oprd1 21 0.66 3.31 18.44 5.00
174 INT30245 Binding of Pdyn 26 0.37 2.31 17 5.00
175 INT26972 Negative_regulation of Tenc1 57 0.57 56.71 16.87 5.00
176 INT30440 Gene_expression of Hps4 15 0.29 2.39 15.31 5.00
177 INT18430 Positive_regulation of Hps4 14 0.24 0.81 14.82 5.00
178 INT1888 Protein_catabolism of F13A1 97 0.99 63.48 14.82 5.00
179 INT655 Positive_regulation of Localization of REN 86 0.70 32.41 13.56 5.00
180 INT11793 Negative_regulation of CA2 78 0.57 19.63 12.35 5.00
181 INT7389 Positive_regulation of Localization of Pdyn 15 0.48 1.68 11.88 5.00
182 INT87698 Gene_expression of WAS 25 0.58 8.75 11.83 5.00
183 INT30236 Negative_regulation of Hps4 8 0.15 1.03 11.4 5.00
184 INT661 Gene_expression of REN 100 0.78 48.21 11.36 5.00
185 INT25170 Positive_regulation of Localization of Car2 78 0.67 15.25 11.24 5.00
186 INT86729 Positive_regulation of CDCP1 37 0.07 18.74 10.76 5.00
187 INT62895 Gene_expression of NOSTRIN 51 0.75 28.8 10.68 5.00
188 INT85048 Regulation of NGF 19 0.62 11.61 10.5 5.00
189 INT101481 Positive_regulation of Lep 81 0.69 62.59 9.95 5.00
190 INT10139 Positive_regulation of F13A1 64 0.56 44.75 9.69 5.00
191 INT23535 Positive_regulation of Localization of CA2 41 0.41 13.52 9.43 5.00
192 INT152668 Negative_regulation of EP300 13 0.38 7.78 9.03 5.00
193 INT34268 Binding of WAS 14 0.47 4.41 8.67 5.00
194 INT13840 Negative_regulation of CPQ 19 0.57 1.25 8.36 5.00
195 INT18185 Gene_expression of Tyr 32 0.76 12.52 8.17 5.00
196 INT87699 Positive_regulation of WAS 16 0.45 5.84 8.03 5.00
197 INT76091 Positive_regulation of NOS3 48 0.61 18.4 7.92 5.00
198 INT57922 Gene_expression of CYP2C9 65 0.78 22.24 7.53 5.00
199 INT11441 Negative_regulation of Anpep 18 0.59 3.73 7.51 5.00
200 INT8684 Positive_regulation of ANGPTL5 45 0.69 36.29 7.47 5.00
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