P:Acular

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Pain Term
Category Drug
Synonyms Ketorolac, Toradol
Pain Specific Yes
Documents 1724
Hot Single Events 200
Hot Interactions 9

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported for Acular. They are ordered first by their pain relevance and then by number of times they were reported for Acular. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT299985 BDKRB2 Regulation of Gene_expression of BDKRB1 1 0.21 0.75 1.16 99.24
2 INT112661 Cpox Positive_regulation of Localization of TNF 1 0.01 0.79 0.52 95.68
3 INT88068 Ptger2 Positive_regulation of Transcription of Ptger4 1 0.15 0 0.36 95.64
4 INT112659 Cpox Positive_regulation of Gene_expression of TNF 1 0.01 0.79 0.52 94.72
5 INT63943 Il1b Positive_regulation of Localization of Calca 2 0.46 0.98 0.88 94.08
6 INT111892 Ptger2 Regulation of Ptger1 1 0.08 2.09 1.55 93.48
7 INT149925 Negative_regulation of Cpox Negative_regulation of Gene_expression of Pde4d 1 0.01 0.39 0.84 86.56
8 INT88069 Il1b Positive_regulation of Transcription of Fos 1 0.04 0 0.36 84.80
9 INT105295 WAS Regulation of PTGS1 1 0.02 0.13 1.27 81.04
10 INT76761 Kctd1 Negative_regulation of RFFL 1 0.00 0.5 0.63 76.92
11 INT334379 Ros1 Regulation of Cat 1 0.04 0.08 0.21 69.76
12 INT124383 ACOT1 Positive_regulation of MME 1 0.01 0.17 0.22 68.48
13 INT119313 Cpox Regulation of Gene_expression of Ptger2 1 0.02 0.6 0.74 65.36
14 INT119314 Ptgs1 Regulation of Gene_expression of Ptger2 1 0.01 0.6 0.73 64.96
15 INT112660 TNF Regulation of Tnf 1 0.02 0.94 0.08 25.00
16 INT163078 IL4 Positive_regulation of Gene_expression of STAT6 1 0.26 0 0 10.00
17 INT149982 Negative_regulation of Cpox Negative_regulation of Gene_expression of FLII 1 0.01 0 0 10.00
18 INT299989 PRKCA Positive_regulation of Gene_expression of IL8 1 0.04 0.45 0.67 6.32
19 INT107322 Positive_regulation of TRPV1 Positive_regulation of Localization of IL8 3 0.13 1.64 2.5 5.00
20 INT238914 Positive_regulation of CNR1 Positive_regulation of Phosphorylation of MAPK1 1 0.19 3.22 2.35 5.00
21 INT351281 AP1M2 Regulation of NCOR2 1 0.00 0.85 1.9 5.00
22 INT238916 CNR1 Positive_regulation of Phosphorylation of MAPK1 1 0.19 1.61 1.17 5.00
23 INT299986 BDKRB2 Regulation of Gene_expression of SPANXB1 1 0.29 0.51 1.02 5.00
24 INT299988 IL6 Positive_regulation of Localization of IL8 1 0.05 0.81 0.94 5.00
25 INT299990 BDKRB2 Positive_regulation of TRPV1 1 0.43 0.74 0.84 5.00
26 INT299987 SPANXB1 Positive_regulation of TRPV1 1 0.20 0.71 0.82 5.00
27 INT238913 MAPK3 Regulation of Positive_regulation of MAPK1 1 0.11 0.39 0.42 5.00
28 INT332481 ANXA1 Regulation of SGPP2 1 0.45 1.01 0.22 5.00
29 INT195423 COMT Negative_regulation of GBE1 1 0.00 0.22 0.19 5.00
30 INT195424 SNRNP70 Negative_regulation of GBE1 1 0.00 0.22 0.19 5.00
31 INT232174 GAN Positive_regulation of ODT 1 0.01 0.98 0.14 5.00
32 INT332485 SGPP2 Regulation of ANXA1 1 0.27 0.69 0.13 5.00
33 INT332480 OR2A5 Regulation of SGPP2 1 0.00 0.32 0.1 5.00
34 INT332486 Binding of HSH2D and OR2A5 1 0.00 0.26 0.09 5.00
35 INT332488 OR2A5 Positive_regulation of HSH2D 1 0.00 0.19 0.05 5.00
36 INT332484 ANXA1 Positive_regulation of HSH2D 1 0.18 0.19 0.05 5.00
37 INT332489 Binding of JAM3 and SGPP2 1 0.27 0.24 0.04 5.00
38 INT332483 Binding of JAG1 and SGPP2 1 0.21 0.23 0.04 5.00
39 INT195837 Tlr4 Positive_regulation of Pla2g4a 1 0.01 0.44 0.03 5.00
40 INT195836 Tlr4 Regulation of Gene_expression of Ptges 1 0.00 0.52 0.03 5.00
41 INT195835 Tlr4 Regulation of Ptges 1 0.00 0.52 0.03 5.00
42 INT350486 Cebpb Positive_regulation of IgG2a 1 0.00 0.42 0 5.00
43 INT195823 Binding of Alb and Ptger2 1 0.03 1.46 0 5.00
44 INT332487 ANXA1 Regulation of Gene_expression of SGPP2 1 0.45 0.08 0 5.00
45 INT350487 Cebpb Positive_regulation of Cebpb Positive_regulation of IgG2a 1 0.00 0.42 0 5.00

Single Events

The table below shows the top 200 pain related interactions that have been reported for Acular. They are ordered first by their pain relevance and then by number of times they were reported in Acular. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT6580 Negative_regulation of Ptgs1 929 0.59 381.53 376.26 100.00
2 INT2391 Negative_regulation of PTGS1 501 0.59 207.62 205.6 100.00
3 INT1850 Binding of OXA1L 77 0.48 7.61 15.22 100.00
4 INT21503 Binding of Ptgs1 45 0.48 15.6 22.29 100.00
5 INT83095 Regulation of Gene_expression of BDKRB2 2 0.59 4.06 5.39 100.00
6 INT8465 Regulation of Ptgs1 100 0.57 36.03 44.41 100.00
7 INT133636 Negative_regulation of AKR1E2 1 0.07 0.89 1.09 100.00
8 INT15613 Negative_regulation of Ptgs2 160 0.59 71.08 65.08 100.00
9 INT75918 Negative_regulation of Negative_regulation of Cpox 19 0.23 10.05 14.4 100.00
10 INT45840 Positive_regulation of Gene_expression of Ptgs1 35 0.50 16.07 20.49 100.00
11 INT52690 Positive_regulation of Ptgs2 65 0.68 39.51 30.02 100.00
12 INT9382 Regulation of TRPV1 149 0.62 53.99 77.46 100.00
13 INT35975 Regulation of Cpox 109 0.39 57.88 49.69 100.00
14 INT70504 Regulation of Gene_expression of NOS1 30 0.51 21.72 21.72 100.00
15 INT54020 Regulation of Binding of OXA1L 4 0.51 0.27 1.37 100.00
16 INT31134 Regulation of Binding of ALB 13 0.62 2.51 2.37 100.00
17 INT546 Binding of ALB 311 0.48 85.98 60.14 100.00
18 INT55880 Negative_regulation of Gene_expression of CCL2 49 0.59 22.37 18.09 100.00
19 INT3738 Regulation of Epo 25 0.61 13.73 6.18 100.00
20 INT40249 Regulation of Regulation of Ren 4 0.36 0.83 1.05 100.00
21 INT157666 Positive_regulation of GOPC 335 0.60 120.19 42.75 100.00
22 INT55878 Regulation of Gene_expression of CCL2 34 0.62 15.71 17.97 100.00
23 INT68265 Positive_regulation of Negative_regulation of Ptgs2 3 0.46 0.08 0.92 100.00
24 INT172789 Regulation of Gene_expression of Nos3 15 0.53 16.23 7.86 100.00
25 INT52611 Negative_regulation of Ptgs2 142 0.59 66.31 52.71 100.00
26 INT34969 Negative_regulation of Binding of Ptgs1 4 0.37 1.55 2.55 100.00
27 INT5069 Negative_regulation of Mthfs 69 0.57 22.54 31.36 100.00
28 INT24961 Positive_regulation of Defb22 8 0.03 3.56 6.04 100.00
29 INT86712 Regulation of Gene_expression of Tgfb1 2 0.15 2.03 1.65 100.00
30 INT111891 Regulation of Transcription of Tgfb1 1 0.04 0.68 0.64 100.00
31 INT101026 Positive_regulation of Negative_regulation of Ptgs2 2 0.35 1.01 1.23 100.00
32 INT104777 Regulation of DES 4 0.38 2.38 1.2 100.00
33 INT84375 Regulation of COL1A2 6 0.44 8.75 1.72 100.00
34 INT121234 Negative_regulation of DDAH2 5 0.57 1.64 2.15 99.98
35 INT5903 Negative_regulation of Localization of MPO 10 0.59 5.71 5.45 99.98
36 INT49750 Negative_regulation of CPOX 735 0.58 360.06 274.19 99.96
37 INT50058 Negative_regulation of Cpox 907 0.58 426.28 428.29 99.92
38 INT65245 Gene_expression of Nos3 121 0.78 98.14 41.56 99.92
39 INT49441 Negative_regulation of Cpox 494 0.59 303.22 177.46 99.92
40 INT55879 Gene_expression of CCL2 421 0.78 240.74 166.02 99.92
41 INT23122 Gene_expression of Ptger3 31 0.72 11.94 11.37 99.92
42 INT940 Negative_regulation of Ptgs1 219 0.59 104.34 95.97 99.92
43 INT141299 Negative_regulation of Gene_expression of Nos3 9 0.55 5.38 2.17 99.88
44 INT5591 Regulation of Gene_expression of Fos 425 0.62 129.06 265.78 99.88
45 INT16868 Gene_expression of Il6 807 0.78 499.48 256.57 99.86
46 INT91906 Regulation of Gene_expression of Il10 13 0.58 8.92 7.06 99.86
47 INT48895 Gene_expression of Il10 333 0.78 221.2 138.52 99.86
48 INT19668 Regulation of SPANXA1 4 0.16 1.21 2.26 99.84
49 INT10706 Regulation of Il6 150 0.62 93.23 62.34 99.84
50 INT74286 Regulation of Il10 42 0.44 28.06 19.44 99.84
51 INT717 Regulation of F2 29 0.61 17.46 6.99 99.82
52 INT2609 Localization of ELANE 111 0.81 50.22 26.63 99.78
53 INT53949 Positive_regulation of Gene_expression of Cpox 82 0.65 38.12 25.93 99.78
54 INT9945 Negative_regulation of Csf2 35 0.51 17.85 11.22 99.76
55 INT7991 Gene_expression of SPANXA1 8 0.67 3.41 1.2 99.76
56 INT36168 Regulation of Positive_regulation of Ptger2 5 0.45 0.19 1.76 99.76
57 INT22765 Negative_regulation of Localization of Ptger2 14 0.34 3 5.75 99.76
58 INT314 Positive_regulation of Ren 212 0.70 66.68 55.56 99.74
59 INT5905 Negative_regulation of ELANE 113 0.59 47.43 22.09 99.74
60 INT59987 Gene_expression of BDKRB1 25 0.77 11.95 15.93 99.72
61 INT11013 Negative_regulation of Phosphorylation of Creb1 55 0.59 18.74 34.66 99.72
62 INT66718 Positive_regulation of BDKRB2 21 0.64 9.89 11.6 99.68
63 INT39188 Gene_expression of IGKV5-2 22 0.38 10.95 9.91 99.68
64 INT54238 Positive_regulation of UFM1 7 0.32 3.17 1.43 99.68
65 INT49751 Negative_regulation of Positive_regulation of PTGS1 12 0.45 4.73 7.23 99.68
66 INT5200 Gene_expression of Fos 3083 0.78 894.43 1639.02 99.66
67 INT91276 Positive_regulation of Negative_regulation of Cpox 4 0.27 3.11 2.2 99.64
68 INT34869 Negative_regulation of PTGS2 778 0.59 366.76 319.85 99.62
69 INT112364 Negative_regulation of HIF1A 22 0.57 16.95 2.13 99.62
70 INT32515 Negative_regulation of B4GALNT1 82 0.43 28.1 17.46 99.58
71 INT62124 Gene_expression of NOS1 444 0.78 218.08 114.85 99.56
72 INT8413 Gene_expression of Ptgs1 248 0.78 110.17 108.58 99.56
73 INT20196 Negative_regulation of Gene_expression of Atp7b 8 0.07 2.49 4.63 99.54
74 INT1116 Regulation of Ren 103 0.62 27.66 33.26 99.54
75 INT76758 Positive_regulation of Positive_regulation of RFFL 6 0.35 6.29 3.34 99.54
76 INT6848 Gene_expression of BDKRB2 40 0.75 17.19 20.04 99.50
77 INT88062 Gene_expression of Ptger4 13 0.77 2.4 4.94 99.50
78 INT36336 Gene_expression of Tgfb1 41 0.77 21.82 14.53 99.50
79 INT85148 Transcription of Tgfb1 5 0.52 1.91 0.84 99.50
80 INT51921 Gene_expression of Cpox 501 0.73 229.81 157.81 99.46
81 INT11893 Positive_regulation of Ptger2 96 0.69 31.49 21.92 99.46
82 INT73340 Negative_regulation of Faah 134 0.59 38.67 85.03 99.46
83 INT5202 Positive_regulation of Gene_expression of Fos 1163 0.70 319.28 684 99.44
84 INT651 Positive_regulation of PTGS1 93 0.69 37.27 29.18 99.40
85 INT79693 Regulation of Il4 30 0.51 21.96 8.6 99.40
86 INT88067 Negative_regulation of Positive_regulation of Ptger4 2 0.58 0.3 0.75 99.36
87 INT77652 Negative_regulation of Gene_expression of IL8 99 0.59 67.57 30.21 99.36
88 INT9234 Negative_regulation of Gene_expression of IL6 171 0.59 101.61 53.15 99.36
89 INT58832 Negative_regulation of Positive_regulation of Ptger1 2 0.45 0.3 0.5 99.36
90 INT15920 Regulation of Serpine1 34 0.42 17.36 4.89 99.34
91 INT113876 Negative_regulation of Phosphorylation of Creb3 2 0.17 0.81 2.18 99.34
92 INT11897 Gene_expression of Atp7b 25 0.13 7.85 12.5 99.32
93 INT11011 Positive_regulation of Phosphorylation of Creb1 190 0.70 49.25 112.01 99.32
94 INT11896 Negative_regulation of Atp7b 15 0.11 6.01 6.09 99.32
95 INT19669 Positive_regulation of SPANXA1 4 0.22 1.93 2.29 99.28
96 INT22764 Localization of Ptger2 81 0.64 24.38 26.77 99.26
97 INT59984 Regulation of Gene_expression of BDKRB1 2 0.45 2.08 3.47 99.24
98 INT85437 Regulation of Gene_expression of Cxcl2 5 0.33 3.16 1.79 99.24
99 INT83290 Regulation of Gene_expression of Ccl2 8 0.59 9.06 5.56 99.24
100 INT49532 Regulation of Gene_expression of Il6 43 0.61 25.8 14.99 99.24
101 INT25130 Positive_regulation of Negative_regulation of Ptgs1 14 0.50 5.07 6.29 99.24
102 INT141185 Regulation of Ros1 30 0.24 20.73 8.88 99.22
103 INT1951 Positive_regulation of Tlr4 345 0.70 176.99 62.42 99.20
104 INT163080 Gene_expression of STAT6 5 0.59 3.18 2.94 99.18
105 INT76759 Positive_regulation of RFFL 31 0.35 29.15 9.9 99.12
106 INT113877 Positive_regulation of Phosphorylation of Creb3 1 0.18 0.5 1.01 99.12
107 INT19509 Localization of Ifng 55 0.78 28.25 18.67 99.10
108 INT88059 Positive_regulation of Ptger4 9 0.69 1.41 4.4 99.06
109 INT3467 Positive_regulation of Ptger1 28 0.54 10.59 8.93 99.06
110 INT9238 Gene_expression of IL6 1575 0.78 1135.66 424.22 99.02
111 INT10832 Gene_expression of IL8 1050 0.78 698.72 270 99.02
112 INT72759 Transcription of Cpox 40 0.39 17.26 10 99.00
113 INT72758 Positive_regulation of Transcription of Cpox 15 0.34 5.46 4.75 99.00
114 INT88061 Positive_regulation of Gene_expression of Ptger4 1 0.69 0 0.67 98.98
115 INT27803 Regulation of ACOT1 16 0.38 5.94 4.64 98.96
116 INT66026 Gene_expression of Cxcl1 74 0.78 31.87 23.37 98.94
117 INT52692 Gene_expression of Ptgs2 160 0.78 85.06 55.73 98.94
118 INT48406 Gene_expression of Icam1 277 0.78 238.28 81.71 98.94
119 INT113878 Phosphorylation of Creb3 4 0.24 1.12 3.43 98.92
120 INT5948 Regulation of Il1b 44 0.60 22.8 25.4 98.90
121 INT43906 Regulation of Tlr4 71 0.53 35.18 15.49 98.90
122 INT6645 Positive_regulation of BDKRB1 14 0.66 12.17 13.79 98.88
123 INT82878 Gene_expression of Ccl2 201 0.78 164.95 101.35 98.86
124 INT614 Gene_expression of Cxcl2 29 0.76 25.53 20.8 98.86
125 INT11009 Phosphorylation of Creb1 458 0.82 111.34 221.97 98.84
126 INT9197 Binding of PTGS1 44 0.48 18.48 16.26 98.80
127 INT5904 Localization of MPO 62 0.81 36.37 14.64 98.76
128 INT49171 Gene_expression of Nos1 241 0.78 140.7 104.76 98.72
129 INT64112 Regulation of Gene_expression of Nos1 22 0.62 21.45 14.76 98.72
130 INT79835 Regulation of Il10 28 0.61 21.22 11.29 98.68
131 INT55944 Positive_regulation of Cpox 214 0.57 105.14 81.4 98.64
132 INT3183 Negative_regulation of MRXS5 15 0.41 6.56 3.45 98.64
133 INT76095 Positive_regulation of ISYNA1 117 0.55 79.73 25.86 98.64
134 INT145426 Positive_regulation of Ros1 185 0.56 106.76 27.21 98.62
135 INT53948 Regulation of Gene_expression of Cpox 40 0.51 20.97 13.87 98.60
136 INT130506 Regulation of Ptges 7 0.12 2.56 2.77 98.60
137 INT117579 Regulation of Gene_expression of Ptges 4 0.24 1.41 1.13 98.60
138 INT83529 Positive_regulation of Positive_regulation of Cpox 8 0.29 7.22 6.7 98.56
139 INT68129 Positive_regulation of Hm 1 0.03 0.36 1.64 98.48
140 INT58643 Positive_regulation of HMI 10 0.50 6.59 3.5 98.38
141 INT104679 Gene_expression of Ptges 33 0.41 10.14 7.89 98.38
142 INT6200 Negative_regulation of Gene_expression of Ptger1 3 0.02 0.64 1.17 98.34
143 INT5418 Negative_regulation of Alox5 108 0.57 42.09 31.17 98.30
144 INT9210 Regulation of IL6 166 0.62 125.61 49.95 98.22
145 INT23956 Negative_regulation of DES 12 0.42 10.84 1.82 98.20
146 INT18357 Gene_expression of TRPV1 825 0.78 307.11 382.81 98.16
147 INT58400 Negative_regulation of Tnf 182 0.59 129.97 71 98.16
148 INT3722 Negative_regulation of Acot1 19 0.42 4.88 4.21 98.08
149 INT48767 Negative_regulation of NOS1 312 0.59 154.25 90.32 98.04
150 INT50670 Gene_expression of CPOX 763 0.76 442.13 195.02 98.00
151 INT76978 Negative_regulation of Regulation of Ptger2 1 0.01 0.07 0.44 98.00
152 INT3174 Negative_regulation of Ptger2 43 0.38 20.95 13.43 98.00
153 INT3466 Gene_expression of Ptger1 39 0.75 18.34 15.75 97.98
154 INT5059 Positive_regulation of TNF 1050 0.70 896.51 322.81 97.98
155 INT6056 Negative_regulation of Gene_expression of Fos 601 0.59 193.05 386.84 97.94
156 INT128128 Negative_regulation of Cox4i2 1 0.42 0.2 0.88 97.90
157 INT133118 Negative_regulation of FAAH 25 0.59 13.05 9.37 97.86
158 INT95481 Regulation of Gene_expression of TRPV1 48 0.62 29.3 26.28 97.80
159 INT88060 Positive_regulation of Positive_regulation of Ptger4 1 0.46 0 0.3 97.54
160 INT5228 Positive_regulation of Fos 934 0.70 209.8 503.87 97.52
161 INT51922 Localization of Cpox 24 0.68 12.05 8.59 97.48
162 INT59082 Regulation of Gene_expression of IL1A 3 0.45 2.07 1.2 97.46
163 INT89927 Regulation of Gene_expression of CSF2RA 1 0.12 1.05 0.35 97.46
164 INT89930 Regulation of CSF2RA 3 0.43 1.12 0.39 97.46
165 INT89926 Regulation of IL1A 10 0.60 7.12 1.72 97.46
166 INT39190 Regulation of Gene_expression of IGKV5-2 3 0.18 2.5 2.51 97.36
167 INT16445 Gene_expression of IL1A 60 0.78 44.46 19.19 97.32
168 INT3950 Gene_expression of Ptger2 293 0.77 122.28 62.42 97.28
169 INT1303 Negative_regulation of Npr1 278 0.55 35.1 156.78 97.24
170 INT11335 Regulation of Ptger2 46 0.51 22.3 15.42 97.24
171 INT49172 Regulation of Nos1 43 0.52 27.53 23.66 97.16
172 INT89146 Localization of Tnni3 7 0.51 4.31 2.38 97.12
173 INT161775 Negative_regulation of Localization of Tnni3 1 0.23 0.85 0.86 97.12
174 INT122652 Regulation of B4GALNT1 5 0.11 1.76 0.88 97.12
175 INT89928 Gene_expression of CSF2RA 19 0.75 6.78 1.27 97.10
176 INT6850 Gene_expression of SPANXB1 34 0.46 15.91 16.38 97.08
177 INT120511 Positive_regulation of Gene_expression of Cat 26 0.69 19.82 5.2 97.08
178 INT2649 Regulation of Calca 433 0.62 146.05 330.95 97.08
179 INT89395 Negative_regulation of AKT1 127 0.58 70.27 12.54 97.08
180 INT34488 Negative_regulation of MMP2 85 0.59 41.98 21.72 97.08
181 INT16721 Negative_regulation of Cat 56 0.59 44.44 22.84 97.04
182 INT74688 Regulation of Nos1 55 0.62 22.16 25.3 97.00
183 INT22132 Positive_regulation of CAT 41 0.67 18.64 10.67 96.92
184 INT89401 Negative_regulation of Phosphorylation of AKT1 68 0.58 35.61 2.8 96.92
185 INT97245 Gene_expression of AKT1 217 0.77 119.63 15.59 96.92
186 INT49170 Negative_regulation of Nos1 116 0.59 60.66 58.87 96.72
187 INT120509 Gene_expression of Cat 65 0.77 50.9 9.75 96.68
188 INT59465 Negative_regulation of ISYNA1 41 0.49 21.9 9.46 96.56
189 INT89396 Phosphorylation of AKT1 225 0.82 111.66 19.61 96.52
190 INT73642 Positive_regulation of Ctse 12 0.44 5.57 6.79 96.36
191 INT8483 Positive_regulation of Positive_regulation of TNF 73 0.67 60.35 22.03 96.36
192 INT24441 Positive_regulation of FBF1 13 0.39 6.52 4.29 95.96
193 INT2978 Gene_expression of Tbxa2r 76 0.77 28.4 21.27 95.84
194 INT90673 Gene_expression of LOX 66 0.65 69.71 12.18 95.84
195 INT77433 Regulation of Gene_expression of Nos2 49 0.62 35.07 16.33 95.76
196 INT6852 Localization of TNF 883 0.81 705.95 270.84 95.68
197 INT88064 Positive_regulation of Transcription of Ptger4 1 0.50 0 0.36 95.64
198 INT88066 Transcription of Ptger4 2 0.71 0 0.64 95.64
199 INT116859 Regulation of NOVA2 15 0.44 4.62 1.25 95.28
200 INT66280 Gene_expression of Nos2 534 0.78 330.78 157.07 95.12
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