P:Adalimumab

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pChart

Pain Term
Category Drug
Synonyms None
Pain Specific No
Documents 440
Hot Single Events 200
Hot Interactions 36

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported for Adalimumab. They are ordered first by their pain relevance and then by number of times they were reported for Adalimumab. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT279359 Binding of ADA and TNF 1 0.20 2.61 1.91 100.00
2 INT266742 GOPC Regulation of Positive_regulation of ACR 1 0.02 0.36 1.05 100.00
3 INT209853 TNF Regulation of Gene_expression of CD36 1 0.61 3.41 1.59 100.00
4 INT279360 ADA Negative_regulation of Gene_expression of IFNG 1 0.06 0.51 0.44 100.00
5 INT279369 Binding of ADA and Ifx 1 0.29 0.27 0.35 100.00
6 INT238641 Binding of TNF and Ifx 1 0.07 0.86 0.84 100.00
7 INT238642 Binding of TNF and Ada 1 0.03 0.86 0.84 100.00
8 INT194578 Binding of HOXA10 and BTG3 1 0.00 0.66 0.24 99.76
9 INT209849 TNF Positive_regulation of Gene_expression of CD36 1 0.69 0.18 0.25 99.70
10 INT86179 TNF Positive_regulation of Localization of IL6 5 0.35 1.66 2.17 99.64
11 INT209858 TNF Regulation of Transcription of CD36 1 0.27 0 0.4 99.52
12 INT211129 Negative_regulation of Binding of P4HB and TNF 1 0.10 0.97 0.9 99.30
13 INT279361 Binding of TNF and KLF1 4 0.00 3.72 2.19 99.26
14 INT211128 Binding of P4HB and TNF 1 0.09 0.97 0.9 99.04
15 INT209869 Binding of fc and TRMT2A 1 0.00 0 0.51 98.36
16 INT209848 TNF Positive_regulation of CD36 1 0.46 0.24 0.22 98.08
17 INT268236 Binding of TNF and fc 1 0.04 0.2 0.29 97.96
18 INT131156 Binding of RUNX1 and TNF 2 0.03 3.44 1.42 97.88
19 INT209852 TNF Negative_regulation of Gene_expression of CD36 1 0.43 0.61 0.98 97.60
20 INT326303 Binding of CRP and FKBP4 1 0.15 1.22 0.41 96.36
21 INT211127 Regulation of Binding of MTX1 and TNF 1 0.22 0.71 0.74 95.20
22 INT211130 Binding of MTX1 and TNF 1 0.18 0.7 0.73 95.20
23 INT353009 Binding of GJA8 and VSIG1 1 0.00 0 0.29 94.44
24 INT353010 Binding of GJA8 and TNF 1 0.02 0.24 0.33 94.44
25 INT306259 HDAC9 Negative_regulation of Gene_expression of TNF 1 0.21 0.89 0.78 93.92
26 INT306258 HDAC4 Negative_regulation of Gene_expression of TNF 1 0.09 0.89 0.78 93.92
27 INT284481 Binding of ABCA1 and Ighg1 1 0.00 1.39 0.7 93.92
28 INT293704 Binding of TNF and DDX41 1 0.00 1.01 0.61 91.48
29 INT239474 Binding of ACR and Ifx 1 0.02 0.36 0.45 90.96
30 INT271875 IL1RN Negative_regulation of Binding of IL1B 1 0.01 1.3 1.01 90.92
31 INT209856 IL1A Negative_regulation of Transcription of CD36 1 0.26 0.1 0.22 85.76
32 INT194577 Binding of BTG3 and BDNF-AS 1 0.01 0.31 0.46 85.36
33 INT122163 Binding of TNF and TNFRSF1B 6 0.44 6.06 2.41 82.00
34 INT209854 IL4 Positive_regulation of Gene_expression of CD36 1 0.51 1.2 0.65 81.76
35 INT333969 Binding of TNF and Cd4 1 0.03 1.28 0.39 80.40
36 INT329297 Binding of Cd226 and Aff3 1 0.18 1.54 0.64 80.28
37 INT209851 TGFB2 Negative_regulation of Gene_expression of CD36 1 0.16 0.16 0.21 79.32
38 INT320120 MTX1 Positive_regulation of PTEN 1 0.04 0.09 0.82 78.80
39 INT277832 Binding of TNFRSF1B and NPEPPS 1 0.01 1.1 0.88 78.32
40 INT209857 IL10 Negative_regulation of Gene_expression of CD36 1 0.31 0.16 0.2 77.88
41 INT148704 Binding of TNF and TNFRSF1A 5 0.44 3.3 2.09 77.36
42 INT277831 Binding of TNFRSF1A and NPEPPS 1 0.01 1.1 0.87 77.36
43 INT194576 Binding of ACLY and CD40LG 1 0.07 0.07 0.14 76.68
44 INT231796 Binding of Fcr and Sle1 1 0.01 1.62 0.33 75.04
45 INT186128 Binding of CD2 and CD58 8 0.10 7.59 2.76 69.92
46 INT186125 Negative_regulation of Binding of CD2 and CD58 3 0.12 3.04 1.06 67.36
47 INT306271 IL1A Positive_regulation of Gene_expression of IL6 1 0.30 0.85 0.8 65.20
48 INT316883 Positive_regulation of Binding of Cd19 and Cd22 1 0.02 0.86 0.31 62.00
49 INT316884 Positive_regulation of Binding of Cr2 and Bcr 1 0.06 0.86 0.31 62.00
50 INT316886 Positive_regulation of Binding of Cd22 and Cr2 1 0.02 0.86 0.31 62.00
51 INT316881 Positive_regulation of Binding of Cd19 and Bcr 1 0.08 0.86 0.31 62.00
52 INT316882 Binding of Cd22 and Cr2 1 0.02 1.71 0.61 60.48
53 INT316887 Binding of Cd19 and Cd22 1 0.02 0.85 0.31 60.48
54 INT316885 Binding of Cr2 and Bcr 1 0.06 0.85 0.3 59.80
55 INT316888 Binding of Cd19 and Bcr 1 0.08 0.85 0.3 59.80
56 INT316889 Binding of Cd19 and Cr2 1 0.07 1.7 0.61 59.44
57 INT237195 LGALS4 Positive_regulation of LPT 1 0.03 2.15 0.54 58.88
58 INT237154 LGALS4 Positive_regulation of KIT 1 0.10 1.99 0.47 58.24
59 INT209850 IL4 Positive_regulation of Gene_expression of PPARA 1 0.18 0.23 0.19 56.08
60 INT293703 Binding of DDX41 and C21orf91 1 0.00 0.99 0.42 53.56
61 INT209859 IL4 Positive_regulation of PPARA 1 0.22 1.66 0.69 50.00
62 INT209847 IL4 Positive_regulation of PPARA Positive_regulation of Gene_expression of CD36 1 0.22 0.83 0.34 50.00
63 INT209855 NFE2L2 Positive_regulation of Gene_expression of CD36 1 0.27 0.72 0.32 50.00
64 INT277705 SMAP2 Regulation of TNF 1 0.01 1.23 0.25 50.00
65 INT71176 Binding of ICAM1 and ITGB2 4 0.21 4.93 1.07 45.40
66 INT306264 Binding of IL1A and MTX1 1 0.09 0.74 0.61 42.84
67 INT252633 Binding of TNF and Tnfrsf1b 4 0.05 3.66 1.54 38.80
68 INT252634 Binding of TNF and Tnfrsf1a 4 0.02 2.4 0.46 35.60
69 INT293708 Binding of TNF and Trap1 1 0.00 0.94 0.27 35.04
70 INT231349 Il10 Negative_regulation of Gene_expression of TNF 2 0.23 1.82 0.67 29.12
71 INT251580 Il13 Negative_regulation of Gene_expression of TNF 1 0.08 0.96 0.27 29.12
72 INT251567 Il4 Negative_regulation of Gene_expression of Il10 1 0.01 0.96 0.27 29.12
73 INT251581 Il4 Negative_regulation of Gene_expression of TNF 1 0.05 0.95 0.26 29.12
74 INT275552 Tlr4 Positive_regulation of Gene_expression of Il1 1 0.00 1.28 0.59 26.52
75 INT277791 Binding of Icam1 and Itgal 1 0.03 0.37 0.17 15.20
76 INT194621 TNF Positive_regulation of Gene_expression of Klrk1 1 0.05 0.5 0.32 8.72
77 INT194614 Il15 Positive_regulation of Gene_expression of Klrk1 1 0.04 0.5 0.32 8.72
78 INT295472 IRF6 Positive_regulation of Gene_expression of TNF 2 0.16 0.95 0.27 8.24
79 INT149117 Binding of CD80 and CTLA4 31 0.52 12.7 7.73 5.00
80 INT84921 Binding of NGF and NTRK1 13 0.50 6.39 6.1 5.00
81 INT155484 Binding of CD86 and CTLA4 15 0.52 8.85 6.09 5.00
82 INT176477 Binding of CXCR3 and CXCL10 14 0.25 10.61 5.87 5.00
83 INT127128 Binding of CNR1 and CNR2 8 0.39 3.98 3.97 5.00
84 INT194647 Binding of CD28 and CD80 15 0.40 4.9 3.22 5.00
85 INT186126 Binding of CD28 and CTLA4 9 0.52 4.13 3.12 5.00
86 INT130721 Binding of IL1B and IL1RN 6 0.05 5.29 2.85 5.00
87 INT220062 Binding of NGF and TNFRSF1B 1 0.10 2.21 2.81 5.00
88 INT175329 Binding of ICAM1 and ITGAL 14 0.18 10.06 2.81 5.00
89 INT220061 Binding of TRPV1 and TRPA1 1 0.15 1.7 2.69 5.00
90 INT115367 Binding of IL6 and IL6R 12 0.07 8.16 2.36 5.00
91 INT103548 Binding of TRPV1 and TRPV3 3 0.37 1.82 2.28 5.00
92 INT194646 Binding of CD28 and CD86 7 0.40 2.69 2.21 5.00
93 INT157767 Binding of TLR4 and LY96 8 0.54 4.05 1.95 5.00
94 INT194863 Binding of IL1R1 and IL1RN 5 0.09 2.23 1.64 5.00
95 INT306745 Binding of Il12a and IL23A 1 0.10 3.25 1.56 5.00
96 INT254205 Binding of Myd88 and Tlr4 12 0.19 3.17 1.54 5.00
97 INT220058 NGF Positive_regulation of Gene_expression of BDNF 1 0.12 1.31 1.48 5.00
98 INT220059 NGF Positive_regulation of Positive_regulation of BDNF 1 0.11 1.31 1.48 5.00
99 INT285569 TNF Negative_regulation of Gene_expression of Il6 1 0.03 2.83 1.46 5.00
100 INT220060 Negative_regulation of Binding of NGF and NTRK1 1 0.08 1.11 1.39 5.00
101 INT218309 Binding of CRP and IL6 3 0.23 4.78 1.36 5.00
102 INT186393 Binding of TNF and Tnfrsf1a 9 0.37 8.55 1.29 5.00
103 INT254210 Binding of Cxcr2 and Ccl2 1 0.08 2.39 1.25 5.00
104 INT186355 Il23a Positive_regulation of Gene_expression of Il17a 4 0.12 3 1.24 5.00
105 INT237207 LGALS4 Regulation of Localization of Ik 1 0.00 0.9 1.23 5.00
106 INT197092 TNF Regulation of VEGFA 4 0.21 2.78 1.22 5.00
107 INT194619 Il15 Positive_regulation of Gene_expression of TNF 1 0.24 2.23 1.2 5.00
108 INT176474 Binding of CXCR3 and CXCL9 3 0.22 1.9 1.05 5.00
109 INT181450 Binding of Ccr5 and Ccl3 4 0.18 2.19 1.03 5.00
110 INT206074 Binding of IL6 and IL6ST 7 0.32 3.79 1.01 5.00
111 INT285561 Il23a Positive_regulation of Gene_expression of Il22 2 0.06 2.45 0.93 5.00
112 INT302828 Mapkapk5 Positive_regulation of Mapk1 1 0.07 1.38 0.91 5.00
113 INT183269 Binding of CEBPB and CPOX 1 0.07 1.61 0.89 5.00
114 INT249347 Binding of FOS and JUN 4 0.19 6.15 0.89 5.00
115 INT203101 Binding of Aes and Mtx1 2 0.25 0.24 0.88 5.00
116 INT232417 Binding of Mtx1 and Ifx 1 0.04 0.99 0.86 5.00
117 INT237204 Binding of LGALS4 and Cd3e 1 0.15 2.61 0.8 5.00
118 INT302831 Binding of Creb1 and Mapkapk5 1 0.07 1.3 0.79 5.00
119 INT220056 Binding of NTF3 and NTRK1 1 0.07 1.12 0.78 5.00
120 INT220063 Binding of NTF3 and NTRK2 1 0.09 1.13 0.78 5.00
121 INT184116 Il10 Positive_regulation of Stat3 2 0.18 1.15 0.77 5.00
122 INT220057 Binding of NTS and TNFRSF1B 1 0.08 1.23 0.76 5.00
123 INT275554 Binding of CXCL10 and Cxcr3 1 0.03 2.18 0.71 5.00
124 INT306263 Binding of NFIB and TFAM 1 0.00 1.74 0.7 5.00
125 INT107910 Binding of Tnfrsf11b and Tnfsf11 6 0.30 5.88 0.7 5.00
126 INT186123 Binding of GIF and IL10 1 0.23 1.17 0.69 5.00
127 INT285562 Binding of Il27ra and Il27 1 0.10 2.19 0.67 5.00
128 INT194618 Il17a Positive_regulation of Gene_expression of IL8 2 0.01 1.94 0.67 5.00
129 INT320152 IL6 Positive_regulation of IL1RN 2 0.23 2.59 0.66 5.00
130 INT254230 Ik Negative_regulation of Gene_expression of TNF 1 0.00 1.29 0.65 5.00
131 INT279398 Binding of IL1RN and Il1rn 1 0.00 0.51 0.63 5.00
132 INT254199 Il10 Positive_regulation of Gene_expression of Socs3 2 0.06 0.75 0.63 5.00
133 INT285467 Negative_regulation of Binding of IL1B and IL1RN 1 0.05 1.33 0.61 5.00
134 INT187148 SLEB1 Regulation of Gene_expression of CXCR5 1 0.01 0.97 0.6 5.00
135 INT302833 Gene_expression of Mir155 Negative_regulation of Gene_expression of Mmp3 1 0.03 1 0.57 5.00
136 INT283980 Binding of IL12A and IL23A 2 0.24 1.33 0.57 5.00
137 INT277828 Negative_regulation of Binding of ICAM1 and ITGAL 2 0.22 1.27 0.57 5.00
138 INT237205 LGALS4 Positive_regulation of Localization of Il10 1 0.05 0.65 0.56 5.00
139 INT302832 Tnfsf10 Positive_regulation of Akt1 1 0.04 1.63 0.56 5.00
140 INT254197 Mif Regulation of Ptgs2 1 0.02 1.08 0.55 5.00
141 INT244232 Binding of Ccr5 and Ccl4 3 0.17 1.48 0.55 5.00
142 INT302834 Cd4 Positive_regulation of Gene_expression of Il7 1 0.05 1.02 0.54 5.00
143 INT254200 Mif Regulation of Trp53 1 0.02 0.96 0.52 5.00
144 INT271874 IL10 Negative_regulation of TNF 1 0.07 0.78 0.5 5.00
145 INT302838 TNF Positive_regulation of Sox18 1 0.00 0.71 0.5 5.00
146 INT320121 Binding of PTEN and TNF 1 0.05 0.76 0.49 5.00
147 INT302845 Il7 Positive_regulation of Gene_expression of TNF 1 0.01 0.98 0.49 5.00
148 INT302820 Stat3 Regulation of Positive_regulation of Il7 1 0.04 1.03 0.49 5.00
149 INT252296 TNF Regulation of Gene_expression of Il1 2 0.03 1.28 0.49 5.00
150 INT302823 Stat3 Regulation of Gene_expression of Il7 1 0.04 1.03 0.49 5.00
151 INT252294 TNF Regulation of Gene_expression of Il6 2 0.16 1.28 0.49 5.00
152 INT271873 IL10 Regulation of Gene_expression of IK 1 0.00 0.81 0.47 5.00
153 INT271872 IL10 Regulation of IK 1 0.00 0.81 0.47 5.00
154 INT302839 MIR15A Negative_regulation of Bcl2 1 0.15 1.41 0.47 5.00
155 INT254225 Mapk14 Positive_regulation of Mapk8 1 0.02 0.87 0.46 5.00
156 INT306732 Il17a Positive_regulation of Gene_expression of Il2 1 0.09 1.07 0.46 5.00
157 INT254198 Mapk1 Positive_regulation of Mapk8 1 0.01 0.87 0.46 5.00
158 INT275549 Il10 Positive_regulation of Localization of Hand2 1 0.01 1.3 0.46 5.00
159 INT254216 Mapk14 Positive_regulation of Mapk1 1 0.02 0.87 0.46 5.00
160 INT254222 Mapk1 Positive_regulation of Mapk14 1 0.02 0.86 0.46 5.00
161 INT275550 Hand1 Positive_regulation of Localization of Hand2 1 0.00 1.29 0.46 5.00
162 INT306731 Il22 Positive_regulation of Gene_expression of Il2 1 0.12 1.07 0.46 5.00
163 INT238639 Cd86 Negative_regulation of Negative_regulation of Bcl2 1 0.01 0.97 0.46 5.00
164 INT238638 Gopc Negative_regulation of Gene_expression of Bax 1 0.04 0.85 0.45 5.00
165 INT302829 Mapkapk5 Positive_regulation of Trp53 1 0.07 0.81 0.43 5.00
166 INT186385 Binding of TNF and Tnfrsf1b 4 0.30 3.24 0.42 5.00
167 INT185381 TNF Regulation of TLR2 2 0.31 1.9 0.41 5.00
168 INT187145 Positive_regulation of Binding of CXCR3 and CXCL10 1 0.33 0.56 0.4 5.00
169 INT302824 Mapkapk5 Positive_regulation of Phosphorylation of Hspb2 1 0.11 0.64 0.4 5.00
170 INT187149 Positive_regulation of Binding of CXCR3 and CXCL9 1 0.29 0.56 0.4 5.00
171 INT279392 SFTPA1 Positive_regulation of IL1RN 1 0.00 0.19 0.4 5.00
172 INT302825 Binding of Creb1 and Xpnpep1 1 0.00 0.64 0.39 5.00
173 INT155009 IL23A Positive_regulation of Gene_expression of IL17A 2 0.17 0.62 0.39 5.00
174 INT285560 Il23a Positive_regulation of Il17a 1 0.09 1.45 0.39 5.00
175 INT302836 Negative_regulation of Mapk8 Negative_regulation of TNF Positive_regulation of Mir155 1 0.00 0.48 0.39 5.00
176 INT285571 Binding of IL8 and Il17a 1 0.04 1.03 0.38 5.00
177 INT302815 TNF Positive_regulation of TNF Positive_regulation of Mir155 1 0.00 0.47 0.38 5.00
178 INT302840 Positive_regulation of TNF Positive_regulation of Mir155 1 0.01 0.47 0.38 5.00
179 INT181862 Binding of MPO and PRTN3 2 0.16 1.18 0.38 5.00
180 INT302821 Mdk Negative_regulation of Il1 1 0.02 0.91 0.38 5.00
181 INT302843 TNF Positive_regulation of Mir155 1 0.01 0.47 0.38 5.00
182 INT306254 Binding of TLR2 and LY96 1 0.25 1.29 0.36 5.00
183 INT285568 Binding of TNF and Tnfsf10 1 0.12 1.39 0.36 5.00
184 INT285557 Eae2 Positive_regulation of Cia1 1 0.02 1.85 0.36 5.00
185 INT285465 IL7 Positive_regulation of TNF 1 0.04 0.67 0.35 5.00
186 INT275557 Negative_regulation of Binding of CXCL10 and Cxcr3 1 0.04 1.09 0.35 5.00
187 INT254344 Binding of Col2a1 and Ncoa5 1 0.00 0.98 0.35 5.00
188 INT353020 Binding of CD80 and Positive_regulation of Gene_expression of CD28 1 0.13 0.35 0.34 5.00
189 INT285570 Binding of IL8 and Cdkn1c 1 0.11 0.76 0.34 5.00
190 INT285565 Positive_regulation of Zeb1 Negative_regulation of IL2 1 0.02 0.62 0.33 5.00
191 INT254213 Binding of Jak1 and Tyk2 1 0.09 0.84 0.33 5.00
192 INT285558 Binding of Il11ra1 and Il27 1 0.05 1.1 0.33 5.00
193 INT285566 F8 Negative_regulation of IL2 1 0.00 0.62 0.33 5.00
194 INT302830 Mapk14 Regulation of Mapkapk5 1 0.12 0.53 0.33 5.00
195 INT254217 Tyk2 Positive_regulation of Stat3 1 0.23 0.83 0.33 5.00
196 INT285563 Zeb1 Negative_regulation of IL2 1 0.01 0.62 0.33 5.00
197 INT254209 Jak1 Positive_regulation of Stat3 1 0.18 0.84 0.33 5.00
198 INT302841 Mdk Positive_regulation of Positive_regulation of TNF 1 0.01 0.35 0.33 5.00
199 INT254218 Binding of Il10 and Il10rb 1 0.00 0.87 0.32 5.00
200 INT254226 Binding of Il10 and Il10ra 1 0.00 0.87 0.32 5.00

Single Events

The table below shows the top 200 pain related interactions that have been reported for Adalimumab. They are ordered first by their pain relevance and then by number of times they were reported in Adalimumab. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT6483 Gene_expression of TNF 3152 0.78 2515.62 929.82 100.00
2 INT6481 Binding of TNF 624 0.48 510.2 214.82 100.00
3 INT209866 Regulation of Gene_expression of CD36 27 0.60 10.04 8.42 100.00
4 INT164656 Negative_regulation of Gene_expression of CD36 24 0.57 6.51 5.39 100.00
5 INT132161 Gene_expression of MTX1 48 0.58 26.55 32.32 100.00
6 INT11238 Positive_regulation of ADA 33 0.70 39.7 9.98 100.00
7 INT68202 Gene_expression of ADA 26 0.68 23.15 5.18 100.00
8 INT56160 Binding of Ifx 14 0.36 11.39 5.74 100.00
9 INT195226 Positive_regulation of ACR 23 0.26 7.85 12.62 100.00
10 INT9236 Regulation of Gene_expression of TNF 204 0.62 162.66 72.99 100.00
11 INT72798 Binding of ADA 12 0.47 7.84 3.39 100.00
12 INT131494 Regulation of ADA 8 0.52 7.37 2.97 100.00
13 INT211133 Negative_regulation of MTX1 8 0.19 3.86 4.87 100.00
14 INT194586 Negative_regulation of ACR 8 0.26 2.04 2.41 100.00
15 INT134590 Localization of ADA 7 0.65 8.43 3.96 100.00
16 INT30206 Negative_regulation of ADA 17 0.59 10.03 5.63 100.00
17 INT186134 Binding of IGHA1 5 0.01 4.71 1.99 100.00
18 INT135319 Positive_regulation of Positive_regulation of CRP 20 0.50 26.45 5.61 100.00
19 INT145594 Gene_expression of Mtx1 64 0.57 35.33 30.35 100.00
20 INT103096 Regulation of PPARA 113 0.60 62.47 14.57 100.00
21 INT50212 Gene_expression of Ifx 33 0.75 32.17 7.26 100.00
22 INT279365 Regulation of Regulation of ADA 1 0.23 0 0.33 100.00
23 INT279366 Positive_regulation of Localization of ADA 2 0.42 4.37 0.76 100.00
24 INT22285 Negative_regulation of Mtx1 16 0.49 7.84 8.98 100.00
25 INT157666 Positive_regulation of GOPC 335 0.60 120.19 42.75 100.00
26 INT180183 Regulation of Positive_regulation of GOPC 4 0.26 1.47 0.96 100.00
27 INT192073 Positive_regulation of Gene_expression of ADA 8 0.47 10.35 1.12 100.00
28 INT86411 Negative_regulation of Negative_regulation of TNF 24 0.42 17.6 7.89 100.00
29 INT238636 Regulation of Ada 2 0.15 1.12 1.06 100.00
30 INT238637 Binding of Ada 2 0.26 1.01 0.94 100.00
31 INT19392 Gene_expression of Ada 9 0.77 7.4 3.17 100.00
32 INT5969 Gene_expression of Il1a 221 0.75 96.31 71.38 100.00
33 INT72532 Regulation of Gene_expression of Il1a 13 0.54 4.91 6.71 100.00
34 INT61452 Gene_expression of IL1RAP 15 0.58 7.21 5.09 100.00
35 INT67796 Negative_regulation of CTLA4 13 0.39 8.36 2.39 100.00
36 INT125530 Negative_regulation of Gene_expression of IL1RAP 1 0.12 1.13 0.57 100.00
37 INT125531 Negative_regulation of IL1RAP 1 0.12 1.13 0.57 100.00
38 INT142621 Positive_regulation of Gene_expression of CD36 38 0.70 15.18 13.4 99.98
39 INT74563 Positive_regulation of Gene_expression of ROS1 258 0.61 168.18 34.08 99.98
40 INT6478 Negative_regulation of Binding of TNF 36 0.58 30.42 13.31 99.98
41 INT26706 Positive_regulation of Transcription of CD36 8 0.68 3.32 2.12 99.98
42 INT241869 Negative_regulation of Binding of P4HB 1 0.18 0.89 0.48 99.98
43 INT51054 Negative_regulation of Localization of IL6 45 0.59 24.48 18.97 99.98
44 INT211131 Regulation of Gene_expression of MTX1 3 0.21 1.45 1.97 99.96
45 INT84825 Gene_expression of CD36 121 0.78 43.73 33.23 99.92
46 INT26702 Transcription of CD36 17 0.70 3.56 3.49 99.92
47 INT13354 Transcription of TNF 108 0.72 85.81 42.32 99.92
48 INT169987 Transcription of GOPC 45 0.60 21.88 2.61 99.92
49 INT11353 Gene_expression of SLC3A2 13 0.58 7.31 2.33 99.92
50 INT9220 Gene_expression of Ighg1 125 0.77 85.74 15.92 99.90
51 INT24873 Binding of KLF1 12 0.07 6.73 3.1 99.90
52 INT205265 Regulation of Transcription of TSPO 1 0.21 0.13 0.49 99.90
53 INT115370 Gene_expression of PSIP1 22 0.65 9.45 5.68 99.88
54 INT9660 Regulation of TNF 363 0.62 312.94 139.99 99.84
55 INT15516 Gene_expression of Crp 711 0.77 615.33 173.09 99.84
56 INT58288 Positive_regulation of Gene_expression of Crp 83 0.61 82.23 23.7 99.84
57 INT198662 Positive_regulation of CD36 14 0.68 7.73 2.36 99.84
58 INT36453 Binding of ABCA1 48 0.45 19.9 10.84 99.84
59 INT15514 Negative_regulation of Crp 275 0.59 194.6 64.86 99.82
60 INT69440 Gene_expression of ROS1 752 0.78 477.64 103.83 99.80
61 INT6852 Localization of TNF 883 0.81 705.95 270.84 99.80
62 INT5609 Regulation of Ifx 6 0.60 5.73 3.5 99.80
63 INT182320 Binding of MTX1 14 0.18 8.5 7.65 99.80
64 INT183979 Localization of PSIP1 2 0.73 1.37 0.59 99.80
65 INT5235 Negative_regulation of TNF 924 0.59 772.91 331.98 99.76
66 INT168675 Binding of P4HB 3 0.20 1.98 1.11 99.76
67 INT2065 Binding of BTG3 15 0.36 10.9 4.65 99.76
68 INT5059 Positive_regulation of TNF 1050 0.70 896.51 322.81 99.74
69 INT177467 Negative_regulation of MTRF1 22 0.05 11.84 5.57 99.68
70 INT19428 Gene_expression of MTRF1 42 0.08 27.17 10.43 99.68
71 INT172084 Positive_regulation of Binding of TNF 21 0.50 15.31 6.06 99.68
72 INT19427 Regulation of Gene_expression of MTRF1 4 0.04 1.55 0.7 99.68
73 INT4216 Gene_expression of CD40LG 328 0.78 256.02 44.23 99.62
74 INT53184 Negative_regulation of CYP27A1 46 0.57 16.04 5.28 99.62
75 INT28312 Gene_expression of ABCA1 85 0.72 37.69 9.27 99.62
76 INT9235 Negative_regulation of Gene_expression of TNF 346 0.59 252.98 118.61 99.56
77 INT67822 Binding of SERPINH1 17 0.36 19.05 7.24 99.56
78 INT147514 Negative_regulation of CRYGD 15 0.13 9.41 5.1 99.54
79 INT10721 Gene_expression of BDNF-AS 119 0.76 72.8 16.29 99.54
80 INT60151 Positive_regulation of Positive_regulation of HSD11B1 4 0.45 3.54 0.49 99.54
81 INT38056 Localization of Crp 71 0.78 53.14 17.03 99.52
82 INT136574 Regulation of TNFAIP3 2 0.11 1.33 1.3 99.46
83 INT4004 Gene_expression of IGHG3 321 0.71 221.03 42.33 99.46
84 INT86024 Gene_expression of PPARA 736 0.78 497.93 91.14 99.44
85 INT12891 Negative_regulation of MMP3 41 0.58 17.99 15.06 99.44
86 INT9158 Gene_expression of Tnf 722 0.78 522.01 277.68 99.44
87 INT58400 Negative_regulation of Tnf 182 0.59 129.97 71 99.44
88 INT52800 Negative_regulation of Gene_expression of Tnf 142 0.59 92.27 55.47 99.44
89 INT117598 Regulation of ACR 118 0.26 41.25 48.01 99.40
90 INT29496 Gene_expression of MMP3 136 0.75 49.49 41.78 99.36
91 INT22056 Positive_regulation of CYBB 88 0.68 32.13 7.95 99.32
92 INT103094 Binding of PPARA 308 0.47 177.26 34.75 99.32
93 INT57360 Gene_expression of STAR 31 0.66 12.72 2.24 99.28
94 INT46121 Negative_regulation of SERPINH1 14 0.38 10.84 4.41 99.24
95 INT116433 Gene_expression of CYBB 93 0.70 50.44 11.91 99.20
96 INT44015 Binding of Cd86 16 0.31 5.92 3.58 99.16
97 INT271886 Transcription of TNFRSF1B 1 0.51 1.76 1.23 99.16
98 INT65611 Regulation of OR3A1 3 0.03 0.74 1.77 99.12
99 INT143230 Gene_expression of CRYGD 61 0.65 52.11 15.93 99.12
100 INT194592 Regulation of Gene_expression of CRYGD 1 0.02 0.69 0.45 99.12
101 INT107608 Regulation of Negative_regulation of MMP14 1 0.17 0.4 0.34 99.10
102 INT95607 Regulation of MMP1 19 0.60 7.86 6.18 99.10
103 INT86332 Binding of FCAMR 2 0.36 1.4 1.33 99.06
104 INT10916 Positive_regulation of BDNF-AS 39 0.49 25.88 5.28 99.04
105 INT80124 Negative_regulation of VEGFA 450 0.58 311.19 44.53 98.98
106 INT17612 Gene_expression of CRP 676 0.78 580.61 119.03 98.96
107 INT78024 Gene_expression of ACLY 73 0.75 59.15 18.54 98.96
108 INT130176 Positive_regulation of Gene_expression of CRP 125 0.66 137.06 25.9 98.96
109 INT184743 Localization of BTG3 4 0.68 3.6 0.78 98.96
110 INT12082 Localization of IL6 365 0.81 241.78 105.78 98.96
111 INT6482 Positive_regulation of Gene_expression of TNF 659 0.70 569.88 210 98.88
112 INT101517 Negative_regulation of PPARA 168 0.57 112.24 21.41 98.88
113 INT115369 Positive_regulation of Gene_expression of PSIP1 4 0.49 4.92 1.88 98.88
114 INT126016 Negative_regulation of Gene_expression of fc 6 0.21 5.78 1.61 98.86
115 INT48901 Negative_regulation of IL6 186 0.57 136.33 57.87 98.80
116 INT9234 Negative_regulation of Gene_expression of IL6 171 0.59 101.61 53.15 98.80
117 INT66347 Gene_expression of MLL 29 0.65 14.82 3.18 98.80
118 INT2064 Positive_regulation of BTG3 29 0.49 25.58 15.37 98.72
119 INT68684 Gene_expression of VEGFA 2371 0.78 1742.52 259.2 98.68
120 INT48232 Gene_expression of MMP1 245 0.78 96.31 57.72 98.68
121 INT231794 Binding of Fcr 4 0.07 3.08 1.07 98.68
122 INT107605 Gene_expression of MMP14 26 0.64 25.88 4.49 98.68
123 INT73850 Transcription of TSPO 6 0.59 0.83 0.61 98.68
124 INT70050 Negative_regulation of IL10 56 0.58 37.45 12.39 98.66
125 INT73497 Regulation of IL10 33 0.45 22.6 9.19 98.66
126 INT279364 Regulation of Negative_regulation of IL10 1 0.04 0.49 0.39 98.66
127 INT279367 Negative_regulation of Regulation of IL10 1 0.06 0.49 0.39 98.66
128 INT18009 Positive_regulation of CRP 518 0.70 553.03 103.74 98.64
129 INT9238 Gene_expression of IL6 1575 0.78 1135.66 424.22 98.64
130 INT2006 Gene_expression of fc 104 0.34 64.91 19.08 98.62
131 INT103554 Positive_regulation of MTX1 19 0.45 11.23 10 98.60
132 INT55698 Regulation of Binding of TNF 13 0.44 8.98 4.74 98.60
133 INT19609 Positive_regulation of PSIP1 4 0.49 4.54 2.04 98.56
134 INT163134 Gene_expression of ACR 78 0.65 30.39 38.48 98.50
135 INT2774 Binding of Crp 241 0.48 195.89 44.39 98.50
136 INT107607 Negative_regulation of MMP14 10 0.37 6.05 1.83 98.48
137 INT211125 Positive_regulation of Regulation of TSS 1 0.02 0.19 1.03 98.40
138 INT78713 Negative_regulation of Ngfr 9 0.54 7.07 6.73 98.40
139 INT122165 Binding of TNFRSF1B 8 0.28 7.46 4.87 98.28
140 INT15515 Positive_regulation of Crp 700 0.70 604.24 150.15 98.24
141 INT8640 Positive_regulation of HSD11B1 332 0.67 377.84 22.36 98.22
142 INT194587 Negative_regulation of Gene_expression of CRYGD 1 0.02 0.78 0.47 98.20
143 INT156108 Regulation of TSS 5 0.23 0.59 1.45 98.16
144 INT54571 Positive_regulation of NFKB1 263 0.70 138.99 87.32 98.16
145 INT209864 Regulation of Positive_regulation of FANCB 1 0.13 0 0.24 98.04
146 INT11331 Positive_regulation of FANCB 5 0.49 2.23 1.09 98.04
147 INT67112 Positive_regulation of fc 27 0.58 21.17 7.2 98.04
148 INT55671 Gene_expression of Ik 151 0.27 80.1 48.49 97.96
149 INT107606 Negative_regulation of MMP1 38 0.42 11.94 10.01 97.94
150 INT52732 Negative_regulation of CRP 169 0.59 138.47 40.33 97.92
151 INT20121 Negative_regulation of CYBB 34 0.54 15.5 4.44 97.92
152 INT232413 Positive_regulation of Ifx 9 0.49 2.58 4.13 97.88
153 INT177998 Binding of RUNX1 7 0.35 7.12 2.08 97.88
154 INT101412 Negative_regulation of CDAN1 16 0.57 6.41 1.61 97.76
155 INT194583 Positive_regulation of Gene_expression of CRYGD 4 0.02 1.38 0.85 97.72
156 INT19431 Positive_regulation of Gene_expression of MTRF1 5 0.05 3.13 0.95 97.72
157 INT83451 Positive_regulation of Gene_expression of CD40LG 26 0.60 22.81 6.25 97.72
158 INT88390 Gene_expression of LGALS4 27 0.69 12.28 4.15 97.72
159 INT237181 Negative_regulation of Gene_expression of LGALS4 1 0.52 2.18 0.61 97.72
160 INT10248 Gene_expression of KRT20 436 0.78 231.96 32.88 97.48
161 INT19929 Negative_regulation of Positive_regulation of TNF 52 0.59 38.16 16.51 97.40
162 INT209865 Negative_regulation of Transcription of CD36 1 0.57 0.15 0.32 97.36
163 INT25223 Positive_regulation of Gene_expression of IFNG 41 0.67 36.97 15.89 97.34
164 INT3038 Gene_expression of INS 1583 0.78 1174.16 107.01 97.30
165 INT5056 Gene_expression of IFNG 216 0.78 137.52 74.57 97.18
166 INT143231 Positive_regulation of CRYGD 20 0.49 14.87 3.67 97.12
167 INT102251 Positive_regulation of Positive_regulation of Crp 24 0.58 29.62 7.5 97.12
168 INT13353 Positive_regulation of Tnf 332 0.70 248.75 148.1 97.12
169 INT194591 Negative_regulation of Gene_expression of ACR 2 0.07 0.33 1.23 96.88
170 INT9233 Negative_regulation of Gene_expression of IL1B 114 0.59 56.99 41.82 96.72
171 INT11378 Negative_regulation of Positive_regulation of IL1B 23 0.59 10.28 7.26 96.72
172 INT137400 Regulation of Mtx1 16 0.52 9.19 9.45 96.68
173 INT151823 Binding of Tnfrsf1b 19 0.42 17.92 7.31 96.68
174 INT5973 Regulation of IL1B 109 0.62 66.6 39.88 96.68
175 INT823 Negative_regulation of ESR1 144 0.58 63.72 22.52 96.64
176 INT19429 Positive_regulation of MTRF1 3 0.08 1.62 0.75 96.60
177 INT211135 Positive_regulation of Localization of MTX1 2 0.23 2.14 2.14 96.56
178 INT99911 Localization of MTX1 5 0.45 3.81 3.07 96.56
179 INT8483 Positive_regulation of Positive_regulation of TNF 73 0.67 60.35 22.03 96.52
180 INT119831 Gene_expression of PTEN 55 0.75 40.37 8.57 96.50
181 INT18010 Positive_regulation of CD40LG 122 0.70 100.8 18.46 96.48
182 INT9082 Positive_regulation of ESR1 238 0.69 148.51 36.69 96.48
183 INT53475 Gene_expression of MRI1 116 0.59 77.68 33.98 96.32
184 INT177586 Positive_regulation of Gene_expression of MRI1 9 0.33 4.97 2.91 96.32
185 INT51265 Phosphorylation of TNF 32 0.81 25.33 10.75 96.24
186 INT237178 Negative_regulation of Binding of LGALS4 1 0.52 1.05 0.08 96.24
187 INT66029 Negative_regulation of Tnf 100 0.59 84.28 48.16 96.16
188 INT118124 Binding of USE1 24 0.16 16.64 5.44 96.16
189 INT65610 Negative_regulation of OR3A1 2 0.05 0.64 0.97 96.12
190 INT11381 Positive_regulation of IL1B 330 0.70 209.31 100.9 95.84
191 INT74392 Binding of LGALS4 4 0.43 7.23 1.65 95.84
192 INT347182 Negative_regulation of TNFAIP3 3 0.23 5.6 0.84 95.80
193 INT25607 Binding of Il1 82 0.47 64.4 23.9 95.76
194 INT5972 Gene_expression of IL1B 948 0.78 510.91 263.97 95.52
195 INT211132 Positive_regulation of Gene_expression of MTX1 4 0.23 2.71 2.94 95.48
196 INT80036 Positive_regulation of FAS 42 0.67 42.22 9.4 95.20
197 INT11802 Gene_expression of KLF1 11 0.65 6.81 1.41 95.00
198 INT48693 Regulation of VEGFA 268 0.62 191.88 31.52 94.96
199 INT102987 Regulation of MMP3 23 0.60 9.35 9.54 94.96
200 INT6484 Binding of IL1B 122 0.47 75.84 35.07 94.88
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