P:Alfenta

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Pain Term
Category Drug
Synonyms Alfentanil, Rapifen
Pain Specific No
Documents 1398
Hot Single Events 161
Hot Interactions 3

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported for Alfenta. They are ordered first by their pain relevance and then by number of times they were reported for Alfenta. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT19535 Binding of ADRA1D and ALB 3 0.42 0.8 1.15 100.00
2 INT77982 Binding of YY1 and Oprm1 2 0.17 0.17 1.06 90.32
3 INT351281 AP1M2 Regulation of NCOR2 1 0.00 0.85 1.9 87.76
4 INT252877 Prkaca Positive_regulation of Regulation of Grip2 1 0.01 0.22 0.94 5.00
5 INT252878 Prkaca Regulation of Regulation of Grip2 1 0.01 0.22 0.94 5.00
6 INT252880 Positive_regulation of Prkaca Positive_regulation of Gene_expression of Tacr1 1 0.02 0.29 0.92 5.00
7 INT252879 Creb1 Positive_regulation of Gene_expression of Tacr1 1 0.03 0.24 0.91 5.00
8 INT252876 Positive_regulation of Prkaca Regulation of Gene_expression of Tacr1 1 0.01 0.28 0.89 5.00
9 INT252881 Crcp Positive_regulation of Gene_expression of Tacr1 1 0.00 0.28 0.88 5.00
10 INT278812 PYCARD Positive_regulation of VTA1 1 0.09 0.11 0.71 5.00
11 INT206206 Binding of Mcf2l and Obfc1 1 0.02 1.11 0.64 5.00
12 INT278813 Binding of NOVA2 and PYCARD 1 0.13 0 0.38 5.00
13 INT199406 Binding of CYP3A4 and PPIB 1 0.40 0 0.04 5.00

Single Events

The table below shows the top 200 pain related interactions that have been reported for Alfenta. They are ordered first by their pain relevance and then by number of times they were reported in Alfenta. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT3593 Gene_expression of ADRA1D 70 0.75 29.48 20.87 100.00
2 INT10285 Binding of ADRA1D 102 0.47 25.82 31.11 100.00
3 INT546 Binding of ALB 311 0.48 85.98 60.14 100.00
4 INT19539 Positive_regulation of Gene_expression of ADRA1D 10 0.67 9.4 2.9 100.00
5 INT12333 Regulation of CYP3A 18 0.62 2.25 6.74 100.00
6 INT69314 Binding of CYP3A 16 0.48 1.78 2.19 100.00
7 INT63057 Regulation of CYP3A4 31 0.61 5.75 6.92 100.00
8 INT19537 Negative_regulation of Binding of ALB 6 0.43 3.32 2.26 100.00
9 INT53536 Gene_expression of Bw86 8 0.30 0.89 5.21 100.00
10 INT738 Regulation of POMC 459 0.62 111.19 243.74 100.00
11 INT103879 Regulation of Binding of DRD2 1 0.23 0.13 0.79 100.00
12 INT27590 Negative_regulation of Phex 5 0.36 2.38 2.26 100.00
13 INT51269 Gene_expression of HIST2H2AA3 16 0.56 10.16 6.55 100.00
14 INT56221 Regulation of MPO 8 0.61 8.44 1.84 100.00
15 INT1395 Negative_regulation of Penk 537 0.59 87.33 389.81 100.00
16 INT103881 Positive_regulation of Binding of DRD2 4 0.69 2.01 2.18 99.98
17 INT50210 Negative_regulation of Positive_regulation of Vegfc 2 0.37 0.24 2.05 99.98
18 INT103880 Positive_regulation of DRD2 9 0.67 5.57 5.93 99.98
19 INT127 Positive_regulation of ACOT1 16 0.32 5.12 6.57 99.98
20 INT58250 Negative_regulation of Imacq 1 0.06 0 0.97 99.98
21 INT234 Binding of Alb 151 0.48 52.34 32.97 99.98
22 INT5979 Gene_expression of Oprd1 428 0.78 75.64 320.32 99.98
23 INT162 Regulation of Prl 794 0.62 165.01 322.24 99.92
24 INT1975 Regulation of Regulation of Prl 32 0.59 5.78 18.53 99.92
25 INT6699 Positive_regulation of ADRA1D 65 0.70 22.72 20.31 99.90
26 INT3757 Positive_regulation of Gene_expression of ALB 45 0.69 23.73 6.85 99.90
27 INT19536 Positive_regulation of Gene_expression of MPG 2 0.49 0.7 0.39 99.90
28 INT19538 Positive_regulation of MPG 8 0.67 3.21 3.57 99.90
29 INT1976 Regulation of Gene_expression of Prl 80 0.62 20.19 36 99.90
30 INT59793 Regulation of Gene_expression of STH 2 0.44 0.88 0.51 99.90
31 INT1782 Regulation of Gh1 125 0.62 22 55.74 99.90
32 INT878 Regulation of Gene_expression of Gh1 13 0.43 1.13 6.98 99.90
33 INT64858 Negative_regulation of Positive_regulation of sch 1 0.37 0.81 0.36 99.86
34 INT1087 Negative_regulation of Msr1 32 0.57 8.35 10.72 99.84
35 INT73265 Regulation of NRF1 3 0.10 0.33 1.32 99.82
36 INT49774 Binding of DRD2 48 0.48 17.42 20.73 99.80
37 INT10798 Positive_regulation of CYP2D6 24 0.56 5.82 11.31 99.72
38 INT15158 Positive_regulation of Vegfc 6 0.68 1.07 6.52 99.66
39 INT69471 Localization of CYP3A 6 0.73 0.07 1.69 99.62
40 INT2924 Positive_regulation of sch 11 0.50 4.09 3.82 99.62
41 INT10797 Binding of CYP2D6 86 0.48 15.09 31.16 99.60
42 INT35431 Regulation of DFP 3 0.25 1.33 1.97 99.48
43 INT7057 Binding of FAIM3 19 0.48 4.02 13.78 99.48
44 INT37835 Negative_regulation of CPP 61 0.51 31.34 18.57 99.38
45 INT155 Positive_regulation of Prl 1233 0.70 317.93 457.82 99.36
46 INT874 Positive_regulation of Gh1 244 0.70 27.17 97.98 99.36
47 INT15357 Positive_regulation of STH 7 0.49 4.55 1.6 99.36
48 INT60779 Negative_regulation of CYP3A 63 0.59 8.38 21.27 99.34
49 INT60425 Positive_regulation of INTU 1 0.40 0 0.7 99.32
50 INT55532 Binding of Cyp4b1 1 0.09 0.05 0.45 99.28
51 INT528 Gene_expression of Prl 693 0.78 217.18 192.2 99.26
52 INT59792 Gene_expression of STH 14 0.75 15.2 0.61 99.26
53 INT873 Gene_expression of Gh1 130 0.76 26.15 46.75 99.26
54 INT2330 Regulation of CB 78 0.10 20.46 32.6 99.14
55 INT12129 Gene_expression of CYP3A4 107 0.78 23.11 27.6 99.06
56 INT70877 Gene_expression of PPIG 72 0.75 22.39 10.93 99.06
57 INT70879 Gene_expression of CYP20A1 2 0.17 0.1 0.44 99.06
58 INT12413 Gene_expression of MPG 11 0.76 3.13 1.94 99.00
59 INT685 Regulation of AVP 124 0.62 34.9 39.91 98.88
60 INT921 Regulation of GH1 172 0.60 52.88 51.04 98.88
61 INT7474 Gene_expression of Man2a2 38 0.67 3.31 18.42 98.84
62 INT31404 Positive_regulation of Gene_expression of AFM 2 0.36 0.13 0.48 98.84
63 INT31402 Gene_expression of AFM 5 0.49 0.34 0.56 98.84
64 INT992 Regulation of S100A4 21 0.60 1.47 1.46 98.84
65 INT5409 Negative_regulation of G6pd 33 0.57 29.21 7.64 98.80
66 INT3758 Gene_expression of ALB 326 0.78 184.65 38.75 98.70
67 INT1020 Negative_regulation of BCHE 109 0.59 44.86 16.4 98.68
68 INT123325 Gene_expression of CYP3A7 2 0.21 0.49 0.4 98.66
69 INT60187 Positive_regulation of Lbm1 2 0.43 11.43 0.36 98.64
70 INT7093 Negative_regulation of CYP2B6 146 0.58 37.3 48.39 98.44
71 INT50031 Negative_regulation of Gene_expression of CYP2B6 5 0.57 2.37 1.29 98.44
72 INT31403 Positive_regulation of AFM 3 0.29 5.57 1.38 98.44
73 INT5904 Localization of MPO 62 0.81 36.37 14.64 98.42
74 INT2451 Positive_regulation of Avp 355 0.70 102.66 147.69 98.40
75 INT10796 Gene_expression of CYP2B6 131 0.77 30.14 35.27 98.36
76 INT10654 Negative_regulation of SGSM3 31 0.57 12.24 11.7 98.36
77 INT2040 Positive_regulation of CYP2B6 95 0.69 34.3 25.6 98.12
78 INT24610 Positive_regulation of CCHCR1 9 0.70 1.71 2.59 98.00
79 INT80534 Positive_regulation of Positive_regulation of CCHCR1 1 0.47 0.09 0.3 98.00
80 INT52132 Positive_regulation of Negative_regulation of Abat 9 0.50 0.53 7.03 97.96
81 INT6042 Binding of Oprm1 248 0.48 31.77 154.34 97.88
82 INT22210 Gene_expression of CYP1A2 45 0.78 4.95 10.66 97.82
83 INT56870 Gene_expression of CYP2D6 87 0.78 8.83 37.53 97.82
84 INT9904 Gene_expression of CYP2E1 64 0.78 13.11 14.65 97.82
85 INT57922 Gene_expression of CYP2C9 65 0.78 22.24 7.53 97.82
86 INT70878 Gene_expression of CYP2A6 17 0.75 4.25 2.02 97.82
87 INT65880 Gene_expression of CYP2C8 25 0.77 9.49 1.92 97.82
88 INT4207 Regulation of Avp 267 0.62 63.72 115.33 97.72
89 INT825 Negative_regulation of ADRA1D 54 0.58 20.25 22.78 97.68
90 INT10848 Negative_regulation of Gene_expression of AVP 13 0.59 6.76 2.71 97.66
91 INT50579 Binding of CYP3A4 84 0.48 17.52 17.45 97.44
92 INT2211 Negative_regulation of Abat 267 0.59 66.51 200.98 97.36
93 INT50209 Regulation of Vegfc 4 0.46 0.97 4.28 97.24
94 INT8052 Negative_regulation of COMP 46 0.58 13.73 2.22 97.20
95 INT531 Gene_expression of GH1 376 0.75 193.45 46.24 97.14
96 INT3679 Gene_expression of AVP 171 0.78 72.9 35.23 97.14
97 INT77897 Negative_regulation of Bag3 1 0.00 0.46 0.6 97.04
98 INT1396 Binding of Penk 355 0.48 22.79 269.65 97.00
99 INT27955 Negative_regulation of Gene_expression of Ngf 16 0.59 10.43 10.17 96.96
100 INT129645 Negative_regulation of Gene_expression of TAC1 5 0.42 3.33 5.55 96.96
101 INT48765 Gene_expression of MT1L 1 0.58 0.05 0.54 96.80
102 INT44550 Positive_regulation of Gene_expression of AVP 38 0.70 22.27 8.62 96.72
103 INT683 Positive_regulation of AVP 173 0.70 74.55 46.41 96.72
104 INT914 Positive_regulation of GH1 292 0.69 100.7 84.91 96.72
105 INT29105 Positive_regulation of OPRK1 68 0.70 7.06 44.69 96.60
106 INT20881 Negative_regulation of OPRK1 20 0.43 3.73 13.37 96.60
107 INT50405 Negative_regulation of CYP3A4 238 0.59 53.65 51.51 96.40
108 INT24326 Gene_expression of Ngf 346 0.78 218.67 184.71 96.40
109 INT7344 Gene_expression of TAC1 132 0.75 35.48 68.26 96.40
110 INT103878 Binding of PTGDR 9 0.48 6.22 7.23 95.72
111 INT4403 Binding of CYP2B6 113 0.48 21.17 33.83 95.24
112 INT4805 Positive_regulation of Localization of TPSAB1 9 0.55 0.32 5.38 95.24
113 INT30386 Negative_regulation of OPRD1 33 0.52 4.34 23.06 94.40
114 INT66899 Gene_expression of Lgmn 1 0.35 0 1.04 94.32
115 INT5590 Negative_regulation of Fos 144 0.59 40.94 81.98 94.24
116 INT30532 Negative_regulation of DFP 4 0.43 0.9 1.7 94.16
117 INT67061 Regulation of T(7;18)50H 3 0.01 0 0.82 93.92
118 INT4806 Localization of TPSAB1 29 0.80 5.05 10.52 93.72
119 INT155216 Negative_regulation of Gene_expression of CYP3A4 9 0.56 3.81 2.71 93.48
120 INT4637 Binding of Adarb1 132 0.41 14.48 67.76 93.44
121 INT5770 Binding of Rbm39 88 0.41 13.23 55.5 93.44
122 INT11788 Positive_regulation of Rrsv 36 0.46 10.08 9.68 93.24
123 INT6580 Negative_regulation of Ptgs1 929 0.59 381.53 376.26 93.12
124 INT17370 Negative_regulation of Negative_regulation of Ptgs1 16 0.22 6.5 6.12 93.12
125 INT17879 Positive_regulation of Ppap2a 17 0.53 9.72 3.8 92.68
126 INT63164 Negative_regulation of Cst7 51 0.50 18.48 20.3 92.24
127 INT161 Regulation of Localization of Prl 615 0.62 65.37 298.66 92.16
128 INT15913 Negative_regulation of CYP2D6 174 0.59 22.45 70.91 92.16
129 INT99698 Positive_regulation of CD53 1 0.01 0.14 0.45 91.44
130 INT10706 Regulation of Il6 150 0.62 93.23 62.34 91.32
131 INT67855 Negative_regulation of PPIG 64 0.57 17.83 13.54 91.24
132 INT12334 Positive_regulation of CYP3A 34 0.70 6.77 7.85 90.80
133 INT5200 Gene_expression of Fos 3083 0.78 894.43 1639.02 90.60
134 INT158 Localization of Prl 2431 0.81 378.96 952.2 90.60
135 INT6437 Binding of YY1 154 0.47 26.3 90.46 90.32
136 INT64743 Positive_regulation of olt 19 0.40 16.46 3.86 89.84
137 INT2339 Positive_regulation of CB 30 0.29 10.68 9.12 89.68
138 INT73768 Positive_regulation of Pip 5 0.59 0.26 0.52 89.16
139 INT57923 Gene_expression of CYP3A 12 0.71 2.62 2 88.88
140 INT70561 Regulation of ESRRB 4 0.27 1.03 0.42 88.00
141 INT351284 Regulation of Localization of AP1M2 1 0.04 0.85 1.9 87.76
142 INT34830 Regulation of PGR 14 0.45 6.99 2.32 87.52
143 INT3530 Regulation of BCHE 18 0.60 5.47 4.12 87.12
144 INT462 Regulation of Pomc 157 0.62 41.67 67.27 87.00
145 INT18894 Gene_expression of CPP 44 0.77 23.05 23.05 86.92
146 INT79126 Gene_expression of Wdyhv1 1 0.07 0.8 1.36 86.88
147 INT6165 Gene_expression of Adarb1 85 0.58 18.39 51.03 86.88
148 INT351285 Localization of AP1M2 1 0.07 0.79 1.89 86.48
149 INT5235 Negative_regulation of TNF 924 0.59 772.91 331.98 85.96
150 INT35716 Positive_regulation of NCOR2 45 0.60 18 23.54 85.44
151 INT235399 Positive_regulation of Binding of PTGDR 2 0.15 1.08 2.33 84.48
152 INT49564 Positive_regulation of PTGDR 8 0.70 3.28 4.62 83.84
153 INT50436 Negative_regulation of Positive_regulation of LIF 1 0.37 0.33 1.42 83.64
154 INT12112 Regulation of ICK 5 0.14 0.76 2.26 83.20
155 INT14018 Negative_regulation of Binding of Rbm39 6 0.31 1.84 4.93 82.72
156 INT33895 Positive_regulation of LIF 9 0.67 2.47 2.34 82.40
157 INT6177 Binding of Htr1a 65 0.47 17.65 30.59 81.48
158 INT10208 Negative_regulation of Binding of Htr1a 18 0.57 13.98 8.91 81.48
159 INT48883 Negative_regulation of GRIN3B 19 0.54 14.53 11.5 81.20
160 INT69561 Positive_regulation of GSTM1 23 0.50 5.69 6.36 80.88
161 INT5412 Regulation of G6pd 9 0.62 1.64 2.87 80.32
162 INT91106 Negative_regulation of LTF 9 0.51 5.73 1.09 79.48
163 INT96199 Negative_regulation of PGP 15 0.59 1.07 2.35 79.36
164 INT109344 Binding of PGP 4 0.37 0.35 0.54 78.48
165 INT41296 Protein_catabolism of Oprd1 8 0.85 0.79 3.48 77.76
166 INT70420 Positive_regulation of Localization of ACOT1 11 0.30 1.26 2.25 76.96
167 INT20721 Localization of ACOT1 47 0.80 11.37 10.95 76.96
168 INT199410 Negative_regulation of Binding of CYP3A4 4 0.43 0.96 0.5 75.84
169 INT64386 Binding of Cyp11a1 13 0.46 5.09 3.01 75.20
170 INT40811 Binding of OPRL1 26 0.48 2.76 18.68 75.00
171 INT2910 Regulation of Abat 169 0.62 36.95 153.53 75.00
172 INT34869 Negative_regulation of PTGS2 778 0.59 366.76 319.85 75.00
173 INT5660 Binding of Oprd1 477 0.48 71.86 342.06 75.00
174 INT8101 Binding of INCENP 42 0.31 16.2 6.68 74.96
175 INT52904 Positive_regulation of LTF 21 0.67 15.58 5.78 74.92
176 INT20260 Positive_regulation of Chkb 41 0.64 21.48 18.53 74.40
177 INT54736 Binding of Bw86 4 0.28 0.15 1.97 73.36
178 INT6855 Binding of NCOR2 71 0.41 15.64 28.96 73.32
179 INT214 Localization of AVP 370 0.81 208.51 91.09 72.88
180 INT6656 Gene_expression of YY1 135 0.75 24.73 72.16 72.72
181 INT1334 Negative_regulation of Binding of Oprl1 29 0.59 3.03 20.62 72.48
182 INT73767 Positive_regulation of Tapr 4 0.02 3.61 0.73 72.40
183 INT1212 Binding of Oprl1 312 0.48 28.6 225.15 70.32
184 INT50058 Negative_regulation of Cpox 907 0.58 426.28 428.29 69.88
185 INT50437 Regulation of LIF 6 0.44 2.12 1.53 69.48
186 INT9856 Binding of Pat 5 0.37 1.48 2.05 69.12
187 INT199408 Positive_regulation of FABP6 2 0.49 0.39 0.25 67.96
188 INT12618 Positive_regulation of IAPP 54 0.68 32.03 2.29 67.76
189 INT22211 Positive_regulation of CYP3A4 110 0.70 22 28.27 67.52
190 INT46833 Positive_regulation of SGSM3 56 0.67 24.49 30.31 67.12
191 INT164813 Localization of Obfc1 3 0.15 0.36 0.76 65.20
192 INT149263 Regulation of Negative_regulation of CYP3A4 4 0.44 1 2.03 64.00
193 INT16723 Regulation of GBE1 16 0.11 4.3 3.7 63.36
194 INT59929 Negative_regulation of CYP2C9 60 0.59 16.33 15.39 62.40
195 INT26602 Negative_regulation of HAGH 1 0.09 0 0.11 61.44
196 INT8053 Regulation of Negative_regulation of MBD2 1 0.16 0 0.5 60.36
197 INT152 Negative_regulation of MBD2 31 0.38 3.95 11.31 59.80
198 INT514 Gene_expression of Adrb2 3 0.53 0.23 2.46 58.16
199 INT152714 Negative_regulation of PISD 3 0.57 1.23 2.29 57.80
200 INT62791 Regulation of Lgmn 6 0.26 0.1 1.78 50.92
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