P:Analgesic

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pChart

Pain Term
Category Drug class
Synonyms Analgesics
Pain Specific Yes
Documents 61223
Hot Single Events 200
Hot Interactions 200

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported for Analgesic. They are ordered first by their pain relevance and then by number of times they were reported for Analgesic. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT35398 Fnd3c2 Negative_regulation of Binding of Alox5 1 0.00 0 0.58 100.00
2 INT35400 Fnd3c2 Negative_regulation of Binding of Alox5 and Mthfs 1 0.00 0 0.58 100.00
3 INT35397 Fnd3c2 Negative_regulation of Binding of Mthfs 1 0.00 0 0.58 100.00
4 INT66535 Binding of Pnoc and Oprl1 43 0.54 5.93 32.4 100.00
5 INT88614 Penk Negative_regulation of Il2 1 0.23 0 1.08 100.00
6 INT164665 Adarb1 Positive_regulation of Negative_regulation of Tens1 1 0.03 0.42 1.97 100.00
7 INT66408 Pomc Positive_regulation of Regulation of HRH1 1 0.01 0 1.58 100.00
8 INT120313 Gnrhr Negative_regulation of Mmp2 1 0.03 0.85 1.07 100.00
9 INT120315 Gnrhr Negative_regulation of Positive_regulation of Ngf 1 0.11 0.85 1.07 100.00
10 INT120318 Gnrhr Negative_regulation of Ngf 1 0.11 0.85 1.07 100.00
11 INT34457 AGT Positive_regulation of POMC 1 0.01 0 0.91 100.00
12 INT34458 AGT Negative_regulation of PENK 1 0.00 0 0.81 100.00
13 INT69424 Binding of Agt and Oprd1 1 0.14 0 0.84 100.00
14 INT110744 Faah Positive_regulation of Positive_regulation of Aif1 1 0.10 0.36 0.4 100.00
15 INT125856 Positive_regulation of Oprm1 Regulation of Positive_regulation of Insrr 1 0.01 0.26 1.43 100.00
16 INT141384 Urb1 Regulation of Faah 2 0.08 0.35 0.99 100.00
17 INT39485 Prl Negative_regulation of Localization of Gnrh1 2 0.40 0 1.06 100.00
18 INT39484 Gnrh1 Negative_regulation of Localization of Prl 1 0.25 0 0.36 100.00
19 INT84434 Calca Negative_regulation of Negative_regulation of Hrh1 1 0.06 0.19 1.44 100.00
20 INT57263 Binding of Oprd1 and Atxn2l 1 0.02 0 1.29 100.00
21 INT57262 Binding of Gria4 and Oprd1 1 0.06 0 1.29 100.00
22 INT89943 Binding of Oprm1 and Il2 1 0.03 0.53 1.28 100.00
23 INT111211 Binding of Drd4 and Chdh 1 0.01 1.34 1.26 100.00
24 INT65373 Notch1 Regulation of Oprd1 1 0.09 0 1.16 100.00
25 INT125301 Nts Positive_regulation of Unc5c 1 0.00 0 1.03 100.00
26 INT125300 Nts Positive_regulation of Ntsr1 1 0.04 0 0.99 100.00
27 INT147474 Nfe2l2 Positive_regulation of Hmox1 1 0.43 0.38 0.9 100.00
28 INT222243 Negative_regulation of Binding of Trpv1 and Ccr5 1 0.21 0.57 0.86 100.00
29 INT222244 Binding of Trpv1 and Ccr5 1 0.19 0.57 0.86 100.00
30 INT159386 Positive_regulation of TRPV1 Positive_regulation of Localization of Calca 1 0.05 0.44 0.69 100.00
31 INT30483 Binding of Oprl1 and Acyp2-ps1 1 0.02 0 0.58 100.00
32 INT126341 Tac1 Regulation of Gene_expression of Tnfrsf10b 1 0.06 0.71 0.52 100.00
33 INT110745 Bphl Positive_regulation of Positive_regulation of Aif1 1 0.03 0.18 0.2 100.00
34 INT69337 Oprm1 Positive_regulation of Atxn2l 1 0.01 0.27 1.43 99.92
35 INT31844 Grpr Regulation of Localization of Prl 1 0.04 0.37 0.47 99.92
36 INT68119 Binding of IL2 and Oprd1 1 0.02 0 0.37 99.88
37 INT12756 Binding of ERVK-5 and U 1 0.00 0.08 0.37 99.84
38 INT77393 Binding of ARRB1 and OPRM1 1 0.15 0 0.82 99.80
39 INT34837 Maob Regulation of Negative_regulation of Mme 1 0.48 0.15 0.92 99.78
40 INT87805 Pnoc Negative_regulation of Gene_expression of Fosl1 1 0.33 0 1.08 99.78
41 INT105786 Positive_regulation of Binding of SGCG and Nts 1 0.22 0.31 0.59 99.78
42 INT105787 Binding of SGCG and Nts 1 0.17 0.31 0.59 99.78
43 INT166221 Negative_regulation of Gls Negative_regulation of Gene_expression of Fos 1 0.50 0.37 0.9 99.78
44 INT92738 Binding of Ephb1 and Tcas1 1 0.00 0.43 2.67 99.76
45 INT140659 Phax Positive_regulation of Trpv1 3 0.49 0.68 2.18 99.76
46 INT166413 Gprasp1 Regulation of D2Mit212 1 0.15 0.31 1.26 99.74
47 INT110522 Oprm1 Positive_regulation of Oprk1 1 0.11 0 1.12 99.74
48 INT15344 Oprd1 Regulation of Localization of Tacr3 1 0.00 0 0.76 99.74
49 INT35399 Binding of Alox5 and Mthfs 1 0.01 0 1.14 99.68
50 INT63407 Binding of Oprl1 and Pck1 1 0.40 0 1.29 99.64
51 INT110407 Htr1a Positive_regulation of Gene_expression of Fos 1 0.50 0.52 0.66 99.62
52 INT42727 Binding of Oprm1 and Trim13 1 0.14 0 2.54 99.58
53 INT106676 Binding of Trpv1 and Phax 18 0.34 4.19 12.36 99.52
54 INT68272 Binding of Oprd1 and G2e3 1 0.00 0.11 1.93 99.52
55 INT68273 G2e3 Negative_regulation of Binding of Oprd1 and G2e3 1 0.00 0.11 1.93 99.52
56 INT109380 Binding of Adarb1 and Fos 1 0.02 0.38 1.19 99.50
57 INT12754 Binding of Oprl1 and U 1 0.00 0.08 0.51 99.44
58 INT12755 Binding of Oprl1 and ERVK-5 1 0.00 0.08 0.51 99.44
59 INT44143 Negative_regulation of Thop1 Negative_regulation of Protein_catabolism of Penk 1 0.46 0 0.99 99.40
60 INT291962 Pag1 Negative_regulation of Gene_expression of Grin2b 1 0.17 1.56 0.92 99.28
61 INT72666 Binding of ODT and Oprm1 1 0.03 0.53 1.5 99.24
62 INT122070 Binding of USHBP1 and Trpv1 1 0.00 0.19 0.48 99.20
63 INT29999 Binding of Ptger3 and Retnlb 1 0.00 0 0.71 99.16
64 INT76062 Gnrhr Positive_regulation of Localization of LH 1 0.10 0 0.9 99.16
65 INT81295 Ifng Positive_regulation of Gene_expression of Nos2 4 0.39 0.87 2.05 99.14
66 INT88885 IRF6 Positive_regulation of Gene_expression of Nos2 1 0.21 0.1 0.81 99.14
67 INT88878 Negative_regulation of Nfkb1 Positive_regulation of Gene_expression of Nos2 1 0.06 0.1 0.81 99.14
68 INT75920 Slc8a1 Negative_regulation of Cpox 1 0.03 0.85 0.89 99.12
69 INT22501 Binding of Calca and Pth 1 0.21 0.07 1.28 99.10
70 INT117404 Binding of Pnoc and OR4F4 1 0.00 0.46 0.86 99.04
71 INT142868 YY1 Positive_regulation of Oprd1 1 0.01 0.1 0.55 98.92
72 INT142947 Binding of ERCC2 and OPRM1 1 0.05 0.3 0.32 98.92
73 INT210830 OPRM1 Negative_regulation of ADCY1 1 0.00 0.06 0.55 98.86
74 INT119744 Binding of BHLHE22 and NAV1 1 0.29 0.49 1.09 98.72
75 INT149632 Binding of HK1 and NCOR2 1 0.01 0.13 1.58 98.62
76 INT264925 D2Mit212 Negative_regulation of Cnr1 1 0.05 0 0.84 98.56
77 INT39109 Binding of INSRR and PDYN 1 0.15 0.45 1.46 98.56
78 INT6409 Binding of NFKBIL1 and Oprm1 1 0.00 0 0.8 98.52
79 INT6408 Binding of NFKBIL1 and Ap1m2 1 0.00 0 0.8 98.52
80 INT128702 Ednra Regulation of EDNRA 1 0.00 0.58 0.84 98.48
81 INT233508 Tlr4 Regulation of Gene_expression of Gpr18 1 0.04 0.45 0.46 98.48
82 INT147506 Binding of Ncam1 and Gtf3a 1 0.03 0.88 0.99 98.44
83 INT147507 Binding of Ret and Gtf3a 1 0.03 0.81 0.92 98.44
84 INT6078 Pomc Positive_regulation of Localization of Penk 13 0.51 0 15.49 98.34
85 INT128701 Ednra Regulation of EDNRB 1 0.17 0.58 0.84 98.24
86 INT199495 Il4 Positive_regulation of Positive_regulation of Oprm1 1 0.00 0.98 0.78 98.20
87 INT199476 Il4 Positive_regulation of Transcription of Stat6 1 0.01 0.97 0.77 98.20
88 INT81011 CNR1 Positive_regulation of Gene_expression of PENK 1 0.54 0 0.75 98.20
89 INT199488 Il4 Positive_regulation of Transcription of Oprm1 1 0.01 0.84 0.73 98.20
90 INT113572 Binding of DMRT1 and OPRM1 1 0.01 0 1.9 98.16
91 INT147504 Binding of Ncam1 and Gdnf 1 0.31 0.87 0.98 98.12
92 INT147505 Binding of Ret and Gdnf 1 0.27 0.81 0.92 98.12
93 INT6079 Pomc Positive_regulation of Penk 9 0.43 0 9.46 98.12
94 INT291964 Phex Regulation of Gene_expression of Grin2b 1 0.08 1.39 1.04 98.04
95 INT161079 Mcs18 Negative_regulation of Trpv1 1 0.40 0.82 1.9 98.04
96 INT49150 GAL Regulation of Localization of Gnrhr 1 0.00 0.09 0.51 98.00
97 INT317509 Oprm1 Negative_regulation of Phosphorylation of Oprd1 1 0.00 0 1.46 97.88
98 INT62176 Binding of PTGS2 and Ptgs1 2 0.00 0.69 0.79 97.84
99 INT39108 Binding of PDYN and YY1 2 0.50 0.44 2.14 97.84
100 INT182704 Binding of NPFF and TP53INP2 1 0.01 0.73 3.28 97.76
101 INT251146 Binding of Grin1 and Dlg2 1 0.36 1.95 3.16 97.64
102 INT40703 Mif Negative_regulation of Negative_regulation of POMC 1 0.24 0.49 0.7 97.60
103 INT127585 Binding of CNR2 and Ctbp1 1 0.00 0.6 0.76 97.48
104 INT127584 Binding of CNR1 and Ctbp1 1 0.00 0.6 0.75 97.48
105 INT317511 Ppp1r9b Regulation of Oprm1 3 0.27 0.33 3.85 97.36
106 INT302118 Binding of Oprm1 and Ppp1r9b 2 0.24 0.26 3.45 97.36
107 INT79339 Phax Regulation of Gene_expression of Tacr1 1 0.07 0 0.78 97.28
108 INT251150 Binding of Nos1 and Dlg2 1 0.30 1.98 2.62 97.20
109 INT28432 ADRA1D Positive_regulation of MPG 1 0.54 0.2 0.19 97.16
110 INT129413 sc Negative_regulation of Trpv1 1 0.01 0.22 0.55 97.12
111 INT142437 Urb1 Negative_regulation of Faah 3 0.41 2.12 1.66 97.08
112 INT69504 Binding of Nos1 and Gatm 1 0.05 0 1.13 97.00
113 INT86518 Ass1 Positive_regulation of Hmox2 1 0.03 0.08 1.27 97.00
114 INT81631 Selenbp2 Negative_regulation of Fas 1 0.03 0.77 0.67 97.00
115 INT81630 Selenbp2 Negative_regulation of Positive_regulation of Fas 1 0.03 0.77 0.67 97.00
116 INT168715 Mapk8 Negative_regulation of Oprk1 1 0.18 0.26 1.75 96.96
117 INT168717 Mapk8 Positive_regulation of Mapk8 Negative_regulation of Oprk1 1 0.19 0.26 1.75 96.96
118 INT162329 Tmc1 Negative_regulation of Gene_expression of Ptges2 1 0.03 0.58 0.47 96.92
119 INT117703 OPRK1 Positive_regulation of Positive_regulation of JUN 1 0.01 0.08 0.47 96.92
120 INT19535 Binding of ADRA1D and ALB 3 0.42 0.8 1.15 96.88
121 INT51224 Gal Negative_regulation of Localization of Oxt 1 0.27 0.39 0.51 96.88
122 INT318472 CA2 Regulation of OPRM1 1 0.17 0 0.51 96.88
123 INT136514 Binding of Grm1 and Grm5 4 0.12 1.8 3.9 96.80
124 INT317551 Binding of Akt1 and Oprm1 1 0.19 0.21 2.74 96.80
125 INT127128 Binding of CNR1 and CNR2 8 0.39 3.98 3.97 96.44
126 INT56134 CALCA Positive_regulation of POMC 2 0.71 0.72 1.68 96.36
127 INT159593 Regulation of Nfkb1 Positive_regulation of Gene_expression of Nos2 1 0.38 0.46 0.74 96.36
128 INT146306 Binding of Chrna9 and Myo5c 1 0.01 0.27 0.48 96.36
129 INT122069 Gpx3 Negative_regulation of Trpv1 1 0.02 0.21 0.51 96.32
130 INT155220 ABCG2 Positive_regulation of Abcc2 1 0.23 0.54 0.76 96.28
131 INT6320 Binding of Rbm39 and Scq1 1 0.03 0 1.92 96.24
132 INT29599 Binding of Cyp21a1 and Adarb1 1 0.01 0 1.38 96.24
133 INT136273 NGF Regulation of Gene_expression of BDNF 2 0.41 1.14 1.78 95.92
134 INT20456 Binding of Pomc and Penk 9 0.41 0.26 3.93 95.88
135 INT108129 GDNF Regulation of Gene_expression of GRHL3 1 0.21 0.39 1.71 95.84
136 INT32396 Oxt Negative_regulation of Pomc 1 0.45 0 0.67 95.84
137 INT168716 Mapk8 Negative_regulation of Insrr 1 0.01 0.25 1.75 95.80
138 INT57956 LOC365260 Negative_regulation of Cck 1 0.11 0 1.3 95.76
139 INT98955 Positive_regulation of Binding of SP3 and CFHR4 1 0.00 0 0.62 95.76
140 INT98953 Positive_regulation of Binding of SP1 and CFHR4 1 0.00 0 0.62 95.76
141 INT189299 Atp6v1e1 Positive_regulation of Htr2a 1 0.01 1.01 1.41 95.72
142 INT87891 Agt Regulation of Cck 1 0.28 0 1.97 95.72
143 INT195544 Lct Positive_regulation of Transcription of Grm2 1 0.01 0.06 0.24 95.72
144 INT195547 Lct Positive_regulation of Transcription of Grm3 1 0.00 0.06 0.24 95.72
145 INT195553 Lct Positive_regulation of Grm2 1 0.02 0.05 0.23 95.72
146 INT195548 Lct Positive_regulation of Grm3 1 0.00 0.06 0.23 95.72
147 INT143270 Binding of Cnr1 and Gprasp1 4 0.54 0.64 4.18 95.68
148 INT153581 Binding of Oprm1 and Prkcg 1 0.00 0 1.44 95.68
149 INT227152 Positive_regulation of Binding of Mop3 and Gpm6a 1 0.00 0 1.39 95.68
150 INT227151 Binding of Mop3 and Gpm6a 1 0.00 0 1.38 95.68
151 INT161653 Gsr Regulation of Gene_expression of Ifih1 1 0.04 1.05 0.46 95.52
152 INT190771 Gene_expression of Il4 Negative_regulation of Gene_expression of Mapk14 1 0.15 1.14 1.13 95.44
153 INT190770 Il4 Negative_regulation of Gene_expression of Mapk14 1 0.20 1.14 1.13 95.44
154 INT98954 Binding of SP1 and CFHR4 1 0.00 0 0.61 95.28
155 INT98952 Binding of SP3 and CFHR4 1 0.00 0 0.61 95.28
156 INT134167 Binding of ADRA2A and APLP1 1 0.09 0.64 0.39 95.24
157 INT83271 Gda Negative_regulation of Napepld 1 0.05 0 0.1 95.24
158 INT65744 Map3k7 Negative_regulation of Gene_expression of Il2 1 0.10 0.74 0.18 94.76
159 INT30575 SST Negative_regulation of Localization of Pomc 1 0.00 0.71 1.06 94.64
160 INT165317 Oprd1 Positive_regulation of Gene_expression of Oprk1 1 0.30 0.24 0.6 94.64
161 INT74014 Binding of TSC1 and XRCC1 1 0.02 1.98 0.09 94.64
162 INT74015 Binding of VHL and XRCC1 1 0.07 3.51 0.09 94.64
163 INT166862 Kcnj6 Positive_regulation of Gene_expression of Oprd1 1 0.15 0 0.52 94.32
164 INT166864 Kcnj9 Positive_regulation of Gene_expression of Oprd1 1 0.07 0 0.52 94.32
165 INT233527 Tlr4 Positive_regulation of ADORA1 1 0.00 0.45 0.47 94.32
166 INT73679 Nkx1-1 Positive_regulation of Tacr3 1 0.22 0.26 1.12 94.28
167 INT139592 Ntsr1 Positive_regulation of Nts 1 0.09 0.17 0.79 94.24
168 INT66428 Dcc Positive_regulation of Fos 2 0.05 0.39 1.29 94.24
169 INT111505 Positive_regulation of Binding of Oprl1 and Ptprg 1 0.01 0 0.71 94.16
170 INT136129 Calca Positive_regulation of ATP8A2 1 0.38 0.89 2.4 94.12
171 INT139593 Ntsr1 Positive_regulation of Rbm39 1 0.01 0.17 0.79 94.12
172 INT168435 Positive_regulation of Binding of GLRX and Gpx1 1 0.05 0.91 0.42 93.96
173 INT61698 G2e3 Regulation of Localization of Abat 1 0.05 0 0.88 93.92
174 INT131807 Bpifa2 Positive_regulation of Localization of Tnf 1 0.32 2.09 1.22 93.84
175 INT284855 Binding of S100a10 and Nav1 4 0.21 0.99 0.88 93.84
176 INT199489 Stat6 Positive_regulation of Oprm1 1 0.02 0.85 0.68 93.80
177 INT130561 NCKIPSD Regulation of SERPINF2 1 0.22 0 0.52 93.76
178 INT161652 Gsr Regulation of Gene_expression of Tnf 1 0.17 0.98 0.46 93.68
179 INT140280 Negative_regulation of Binding of Adora2a and Grina 1 0.21 0.64 0.82 93.64
180 INT140281 Binding of Adora2a and Grina 1 0.19 0.64 0.82 93.64
181 INT233503 Tlr4 Positive_regulation of Adora2b 1 0.06 0.45 0.47 93.52
182 INT34444 Binding of Oprl1 and Ptprg 4 0.03 0.18 4.58 93.48
183 INT111506 Negative_regulation of Binding of Oprl1 and Ptprg 1 0.01 0 0.71 93.48
184 INT110130 NR3C1 Regulation of ADORA1 1 0.04 0.73 0.77 93.48
185 INT21536 Binding of Il2 and Il1 1 0.28 0 1.47 93.44
186 INT21535 Binding of Il2 and Il1f5 1 0.13 0 0.73 93.44
187 INT168434 Binding of GLRX and Gpx1 1 0.04 0.9 0.42 93.36
188 INT90750 Oprd1 Regulation of Positive_regulation of Gpd1 1 0.10 0.25 0.78 93.36
189 INT64744 OR5D2P Negative_regulation of ADCY1 1 0.00 0 0.54 93.36
190 INT114754 Il6 Positive_regulation of Gene_expression of Crp 2 0.08 1.67 0.47 93.36
191 INT114755 Il6 Positive_regulation of Crp 1 0.08 0.41 0.35 93.36
192 INT139594 Binding of Nts and Rbm39 1 0.02 0.19 0.87 93.28
193 INT98346 Negative_regulation of Binding of CPOX and PTGS1 1 0.10 2.91 6.54 93.24
194 INT155621 Tnf Regulation of Transcription of Il1b 1 0.51 0.77 0.49 93.00
195 INT317522 Akt1 Positive_regulation of Phosphorylation of Nos1 1 0.43 0.4 3.13 92.92
196 INT25495 AVP Positive_regulation of CRH 1 0.14 0 0.19 92.84
197 INT25497 AVP Positive_regulation of Localization of CRH 1 0.14 0 0.19 92.84
198 INT161662 Gsr Regulation of Gene_expression of TNF 1 0.01 0.93 0.46 92.80
199 INT264930 Gnaz Positive_regulation of Negative_regulation of Cnr1 1 0.20 0 1.14 92.80
200 INT352196 Igkv12-66 Negative_regulation of Gm10404 1 0.00 1.62 1.34 92.68

Single Events

The table below shows the top 200 pain related interactions that have been reported for Analgesic. They are ordered first by their pain relevance and then by number of times they were reported in Analgesic. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT6580 Negative_regulation of Ptgs1 929 0.59 381.53 376.26 100.00
2 INT5200 Gene_expression of Fos 3083 0.78 894.43 1639.02 100.00
3 INT34869 Negative_regulation of PTGS2 778 0.59 366.76 319.85 100.00
4 INT5660 Binding of Oprd1 477 0.48 71.86 342.06 100.00
5 INT467 Gene_expression of POMC 1048 0.78 332.8 394.16 100.00
6 INT6056 Negative_regulation of Gene_expression of Fos 601 0.59 193.05 386.84 100.00
7 INT65731 Gene_expression of Cnr1 234 0.78 63.82 109.34 100.00
8 INT796 Gene_expression of Penk 1902 0.78 275.47 1057.59 100.00
9 INT443 Localization of POMC 1020 0.81 284.52 443.17 100.00
10 INT1212 Binding of Oprl1 312 0.48 28.6 225.15 100.00
11 INT5979 Gene_expression of Oprd1 428 0.78 75.64 320.32 100.00
12 INT158 Localization of Prl 2431 0.81 378.96 952.2 100.00
13 INT26472 Regulation of Oprm1 191 0.62 35.84 173.1 100.00
14 INT4941 Positive_regulation of Oprd1 345 0.70 74.26 304.41 100.00
15 INT1902 Gene_expression of Cck 348 0.78 70.33 241.92 100.00
16 INT768 Positive_regulation of Oprl1 179 0.70 40.05 156.93 100.00
17 INT5501 Regulation of Oprd1 283 0.62 55.1 249.9 100.00
18 INT18357 Gene_expression of TRPV1 825 0.78 307.11 382.81 100.00
19 INT76660 Gene_expression of Trpv1 691 0.78 329.46 386.42 100.00
20 INT9381 Positive_regulation of TRPV1 523 0.70 187.4 276.05 100.00
21 INT2543 Positive_regulation of Calca 787 0.70 331.13 592.08 100.00
22 INT728 Positive_regulation of Penk 1068 0.70 186.9 636.87 100.00
23 INT797 Regulation of Penk 812 0.62 111.13 542.24 100.00
24 INT15769 Gene_expression of Il1b 146 0.78 114.51 75.35 100.00
25 INT293 Protein_catabolism of Penk 161 1.00 11.71 98.45 100.00
26 INT2651 Positive_regulation of Pomc 403 0.70 95.72 206.24 100.00
27 INT6293 Gene_expression of Oprm1 312 0.78 48.73 215.61 100.00
28 INT2649 Regulation of Calca 433 0.62 146.05 330.95 100.00
29 INT8413 Gene_expression of Ptgs1 248 0.78 110.17 108.58 100.00
30 INT1395 Negative_regulation of Penk 537 0.59 87.33 389.81 100.00
31 INT48953 Positive_regulation of Nos2 486 0.70 239.85 131.87 100.00
32 INT18032 Positive_regulation of Oprk1 108 0.70 30.78 89.7 100.00
33 INT5591 Regulation of Gene_expression of Fos 425 0.62 129.06 265.78 100.00
34 INT16194 Binding of CNR1 82 0.48 20.75 39.59 100.00
35 INT2365 Positive_regulation of Cck 354 0.70 87.8 277.41 100.00
36 INT162 Regulation of Prl 794 0.62 165.01 322.24 100.00
37 INT2540 Negative_regulation of Calca 538 0.59 172.11 384.38 100.00
38 INT1414 Regulation of Oprl1 169 0.62 32.05 139.99 100.00
39 INT65733 Positive_regulation of Cnr1 125 0.70 40.27 67.33 100.00
40 INT1396 Binding of Penk 355 0.48 22.79 269.65 100.00
41 INT4893 Gene_expression of Tacr1 366 0.78 129.67 213.92 100.00
42 INT60126 Regulation of Trpv1 186 0.62 85.53 133.4 100.00
43 INT5759 Positive_regulation of Ptgs1 127 0.69 53.45 53.04 100.00
44 INT50674 Gene_expression of PTGS2 459 0.78 253.33 118.51 100.00
45 INT546 Binding of ALB 311 0.48 85.98 60.14 100.00
46 INT5906 Negative_regulation of Oprm1 125 0.59 19.58 101.57 100.00
47 INT16654 Gene_expression of Insrr 138 0.46 58.96 75.68 100.00
48 INT739 Negative_regulation of POMC 358 0.59 102.28 166.77 100.00
49 INT16260 Gene_expression of Bdnf 671 0.78 283.44 339.1 100.00
50 INT69764 Positive_regulation of Cnr1 126 0.70 67.8 91.49 100.00
51 INT66005 Regulation of Cnr1 47 0.61 19.21 34.52 100.00
52 INT6128 Positive_regulation of Localization of POMC 256 0.70 68.77 121.64 100.00
53 INT1438 Localization of Pomc 360 0.81 101.26 116.47 100.00
54 INT1652 Regulation of Pomc 387 0.62 61.01 186.51 100.00
55 INT3948 Regulation of Cck 291 0.62 58.07 255.88 100.00
56 INT8465 Regulation of Ptgs1 100 0.57 36.03 44.41 100.00
57 INT13353 Positive_regulation of Tnf 332 0.70 248.75 148.1 100.00
58 INT738 Regulation of POMC 459 0.62 111.19 243.74 100.00
59 INT626 Localization of CALCA 289 0.81 125.39 221.15 100.00
60 INT1351 Gene_expression of Pag1 131 0.57 89.48 98.76 100.00
61 INT5680 Gene_expression of Ngf 530 0.78 264.29 310.56 100.00
62 INT5597 Gene_expression of Pdyn 433 0.78 62.97 235.47 100.00
63 INT152532 Gene_expression of AGAP1 1 0.33 0.79 1.56 100.00
64 INT29971 Gene_expression of Oprk1 126 0.78 35.32 93.97 100.00
65 INT2366 Binding of Cck 192 0.48 30.64 163.46 100.00
66 INT695 Binding of POMC 304 0.48 56.66 126.85 100.00
67 INT48952 Negative_regulation of Nos2 204 0.59 101.73 53.15 100.00
68 INT76621 Positive_regulation of Cnr2 32 0.69 17.77 26.57 100.00
69 INT52800 Negative_regulation of Gene_expression of Tnf 142 0.59 92.27 55.47 100.00
70 INT12501 Positive_regulation of Adarb1 166 0.58 36.94 118.92 100.00
71 INT5050 Regulation of Localization of Calca 149 0.62 41.25 148.57 100.00
72 INT6385 Regulation of Man2a2 48 0.61 7.8 24.68 100.00
73 INT88365 Regulation of Faah 18 0.45 6.63 12.54 100.00
74 INT1456 Regulation of Oprl1 61 0.62 19.5 52.87 100.00
75 INT22499 Regulation of Calca 42 0.62 17.32 28.02 100.00
76 INT31186 Negative_regulation of Insrr 81 0.37 24.91 55.94 100.00
77 INT9987 Gene_expression of Abat 296 0.78 95.46 226.34 100.00
78 INT34465 Regulation of Oprd1 34 0.45 7.14 34.29 100.00
79 INT4758 Positive_regulation of Localization of Calca 557 0.70 138.55 411.04 100.00
80 INT7845 Regulation of OPRK1 44 0.62 4.54 30.49 100.00
81 INT2389 Regulation of PTGS1 86 0.61 31.23 28.95 100.00
82 INT4936 Localization of Tacr1 125 0.80 35.7 107.7 100.00
83 INT27258 Regulation of Htr2a 18 0.60 6.37 11.06 100.00
84 INT7028 Localization of Pdyn 90 0.81 8.89 73.54 100.00
85 INT101578 Regulation of Cnr2 26 0.62 16.7 19.12 100.00
86 INT68347 Negative_regulation of Cyp2d4 34 0.58 7.62 18.35 100.00
87 INT18258 Negative_regulation of Thop1 20 0.56 1.6 8.61 100.00
88 INT41230 Gene_expression of Nrm 16 0.67 6.37 21.67 100.00
89 INT71875 Localization of Nfkb1 92 0.78 48.13 22.94 100.00
90 INT1319 Gene_expression of Oprl1 65 0.78 9.34 42.41 100.00
91 INT2490 Regulation of Sct 44 0.62 9.45 13.11 100.00
92 INT48956 Negative_regulation of Positive_regulation of Nos2 34 0.46 13.15 11.15 100.00
93 INT47680 Regulation of Gene_expression of Bdnf 92 0.62 41.61 53.24 100.00
94 INT29107 Regulation of Oprk1 31 0.45 6.16 26.61 100.00
95 INT15796 Regulation of IL2 66 0.61 25.43 20.62 100.00
96 INT63932 Positive_regulation of Ephb1 537 0.70 259.67 296.14 100.00
97 INT6382 Regulation of Binding of Oprd1 36 0.61 7 26.48 100.00
98 INT5506 Positive_regulation of Gene_expression of Pomc 132 0.70 26.78 54.3 100.00
99 INT2408 Regulation of CCK 37 0.61 10.01 26.66 100.00
100 INT451 Regulation of Oxt 142 0.62 22.07 69.42 100.00
101 INT18340 Gene_expression of CRX 16 0.22 13.85 7.13 100.00
102 INT57692 Positive_regulation of Gene_expression of Il1b 50 0.67 43.54 28.29 100.00
103 INT48920 Negative_regulation of Ephb1 107 0.57 43.6 51.02 100.00
104 INT1931 Positive_regulation of Gene_expression of POMC 116 0.70 37.26 38.67 100.00
105 INT1425 Gene_expression of Rbm39 143 0.58 51.32 65.44 100.00
106 INT51530 Negative_regulation of Adk 11 0.56 3.83 9.07 100.00
107 INT7828 Positive_regulation of Oprd1 55 0.69 14.11 42.86 100.00
108 INT5017 Negative_regulation of Tacr1 76 0.58 17 57.07 100.00
109 INT12992 Negative_regulation of Gene_expression of Ptgs1 33 0.42 20.47 11.77 100.00
110 INT62630 Positive_regulation of CNR1 86 0.70 40.34 51.51 100.00
111 INT1976 Regulation of Gene_expression of Prl 80 0.62 20.19 36 100.00
112 INT29105 Positive_regulation of OPRK1 68 0.70 7.06 44.69 100.00
113 INT65536 Negative_regulation of Positive_regulation of Nfkb1 77 0.59 38.86 33.33 100.00
114 INT789 Positive_regulation of YY1 69 0.67 14.07 47.06 100.00
115 INT10706 Regulation of Il6 150 0.62 93.23 62.34 100.00
116 INT59352 Positive_regulation of Fosb 16 0.58 1.89 10.09 100.00
117 INT7340 Regulation of Grin1 87 0.62 30.37 57.93 100.00
118 INT24965 Gene_expression of Igkv4-59 4 0.33 0.26 5.8 100.00
119 INT128921 Negative_regulation of Gene_expression of Ephb1 18 0.49 9.54 14.93 100.00
120 INT3008 Gene_expression of Met2 4 0.58 0 2.55 100.00
121 INT685 Regulation of AVP 124 0.62 34.9 39.91 100.00
122 INT20075 Negative_regulation of Cryz 2 0.38 0 3.11 100.00
123 INT75918 Negative_regulation of Negative_regulation of Cpox 19 0.23 10.05 14.4 100.00
124 INT77339 Positive_regulation of RRM2 5 0.41 1.36 2.88 100.00
125 INT33291 Protein_catabolism of Enpep 15 0.85 0.51 5.41 100.00
126 INT55035 Negative_regulation of Negative_regulation of Il1b 4 0.43 1.46 2.02 100.00
127 INT98621 Regulation of Trpv1 121 0.62 79.24 75.23 100.00
128 INT1486 Negative_regulation of Cpe 85 0.59 28.78 54.08 100.00
129 INT3117 Regulation of Oxt 103 0.61 17.93 32.28 100.00
130 INT2867 Gene_expression of CALCA 247 0.78 78.78 138.47 100.00
131 INT416 Regulation of LH 253 0.62 31.48 125.55 100.00
132 INT651 Positive_regulation of PTGS1 93 0.69 37.27 29.18 100.00
133 INT4769 Regulation of OPRD1 20 0.44 2.05 15.97 100.00
134 INT57512 Negative_regulation of Gm9007 1 0.06 0 4.06 100.00
135 INT165 Regulation of HRH1 12 0.45 1.76 7.57 100.00
136 INT8363 Localization of Nts 135 0.81 14.29 61.71 100.00
137 INT91285 Negative_regulation of P2rx2 29 0.57 12.74 15.48 100.00
138 INT2910 Regulation of Abat 169 0.62 36.95 153.53 100.00
139 INT130672 Binding of Ugt2b7 2 0.22 0.38 2.71 100.00
140 INT1487 Regulation of Cpe 68 0.62 10.24 52.91 100.00
141 INT9382 Regulation of TRPV1 149 0.62 53.99 77.46 100.00
142 INT162140 Negative_regulation of Gene_expression of CRX 1 0.06 1.26 2.49 100.00
143 INT12397 Gene_expression of Oprd1 53 0.78 9.1 31.31 100.00
144 INT350200 Positive_regulation of Localization of Etd 1 0.28 0.28 0.72 100.00
145 INT97368 Negative_regulation of Nav1 62 0.59 41.56 60.27 100.00
146 INT61160 Negative_regulation of Gene_expression of Creb1 37 0.59 17.95 23.17 100.00
147 INT4850 Binding of Tac1 57 0.47 14.25 42.17 100.00
148 INT48766 Regulation of NOS1 73 0.61 37.01 24.59 100.00
149 INT354377 Negative_regulation of Negative_regulation of Map3k12 1 0.10 0 1.27 100.00
150 INT18736 Gene_expression of Ptpn6 19 0.59 4.44 8.06 100.00
151 INT4913 Binding of Pax3 52 0.28 9.57 42.67 100.00
152 INT64737 Regulation of Regulation of Cpe 1 0.05 0 1.8 100.00
153 INT81495 Positive_regulation of CNR2 28 0.67 14.62 14.27 100.00
154 INT20450 Regulation of Binding of Penk 11 0.60 0.47 11.92 100.00
155 INT64738 Regulation of Dpp6 1 0.01 0 1.79 100.00
156 INT64736 Regulation of Regulation of Atxn2l 1 0.01 0 1.78 100.00
157 INT12416 Regulation of Atxn2l 8 0.07 0.25 7.42 100.00
158 INT34268 Binding of WAS 14 0.47 4.41 8.67 100.00
159 INT84427 Positive_regulation of Gene_expression of TSPO 15 0.64 5.05 3.58 100.00
160 INT204139 Positive_regulation of Gene_expression of BCAR1 1 0.23 0.9 1.96 100.00
161 INT5595 Positive_regulation of Pdyn 223 0.70 48.37 130.14 100.00
162 INT73351 Negative_regulation of Pnoc 13 0.42 5.71 14.17 100.00
163 INT1509 Gene_expression of Stxbp1 5 0.51 0.52 1.4 100.00
164 INT63935 Positive_regulation of Gene_expression of Ephb1 52 0.61 24.3 33.05 100.00
165 INT15054 Gene_expression of Mme 48 0.77 42.52 10.63 100.00
166 INT134741 Regulation of NMT2 1 0.23 0.7 1.69 100.00
167 INT13610 Regulation of Acyp2-ps1 10 0.62 3.29 9.4 100.00
168 INT7608 Positive_regulation of Adra2a 66 0.70 17.81 35.15 100.00
169 INT927 Gene_expression of Oxt 184 0.78 44.71 35.79 100.00
170 INT6116 Regulation of Gene_expression of Oprd1 69 0.62 16.43 54 100.00
171 INT20379 Localization of Il4 85 0.73 51.22 20.55 100.00
172 INT21421 Regulation of Gtpbp4 15 0.30 2.7 13.49 100.00
173 INT52690 Positive_regulation of Ptgs2 65 0.68 39.51 30.02 100.00
174 INT52442 Binding of Ptgs1 16 0.35 9.05 8.78 100.00
175 INT5297 Regulation of IFNA2 20 0.56 10.81 5.13 100.00
176 INT350198 Positive_regulation of Gene_expression of Etd 1 0.28 0.48 0.57 100.00
177 INT93281 Negative_regulation of Folh1 12 0.50 5.55 10.63 100.00
178 INT90181 Binding of Hck 2 0.36 0.08 0.49 100.00
179 INT22939 Gene_expression of Csf2 164 0.78 85.1 32.22 100.00
180 INT12575 Regulation of Hpse 33 0.59 17.7 18.45 100.00
181 INT44142 Negative_regulation of Protein_catabolism of Thop1 1 0.41 0 1.24 100.00
182 INT87699 Positive_regulation of WAS 16 0.45 5.84 8.03 100.00
183 INT613 Gene_expression of Alb 268 0.78 149.84 42.78 100.00
184 INT132460 Negative_regulation of Rtn1 1 0.59 0.92 0.98 100.00
185 INT14131 Regulation of HTR1A 34 0.60 9.61 14.74 100.00
186 INT159127 Gene_expression of Nps 49 0.75 16.91 12.06 100.00
187 INT3028 Negative_regulation of Oxt 76 0.58 18.52 24.4 100.00
188 INT13290 Binding of Atxn2l 34 0.18 1.86 28.16 100.00
189 INT20496 Positive_regulation of Protein_catabolism of Penk 7 0.50 0.86 4.42 100.00
190 INT10786 Negative_regulation of Prl 14 0.59 6.43 1.66 100.00
191 INT12001 Regulation of Ngf 97 0.62 54.64 76.25 100.00
192 INT26632 Binding of Acyp2-ps1 12 0.42 0.66 6.16 100.00
193 INT4241 Regulation of CALCA 87 0.62 28.19 55.29 100.00
194 INT13385 Gene_expression of Bad 60 0.76 41.86 6.52 100.00
195 INT6193 Regulation of Gene_expression of Nppa 6 0.45 2.02 2.93 100.00
196 INT6196 Regulation of Nppa 83 0.62 30.31 30.18 100.00
197 INT35284 Positive_regulation of Chrm1 14 0.67 5.64 10.11 100.00
198 INT64436 Gene_expression of P2rx1 93 0.78 32.69 36.12 100.00
199 INT5409 Negative_regulation of G6pd 33 0.57 29.21 7.64 100.00
200 INT7059 Regulation of Adra2a 89 0.62 18.24 48.43 100.00
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