P:Antiemetics

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Pain Term
Category Drug class
Synonyms Alleviate Nausea, Alleviating Nausea
Pain Specific No
Documents 1613
Hot Single Events 40
Hot Interactions 3

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported for Antiemetics. They are ordered first by their pain relevance and then by number of times they were reported for Antiemetics. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT264101 Binding of CYP2D6 and Bche 1 0.07 0.33 0.18 93.04
2 INT353128 Negative_regulation of Binding of TAC1 and B3GAT1 1 0.29 1.95 0.33 91.44
3 INT70226 Binding of TAC1 and B3GAT1 4 0.24 4.5 1.26 90.92
4 INT336713 Binding of CDA and GNPTAB 1 0.02 0.77 0 31.88
5 INT96833 Binding of WAS and Positive_regulation of Cnr1 1 0.02 0.69 0.39 25.00
6 INT96834 Binding of WAS and Positive_regulation of Cnr2 1 0.03 0.69 0.39 25.00
7 INT96836 WAS Positive_regulation of Cnr1 1 0.02 0.69 0.39 25.00
8 INT96835 WAS Positive_regulation of Cnr2 1 0.03 0.69 0.39 25.00
9 INT120236 Binding of Ncoa1 and Insrr 1 0.00 0.15 0.28 25.00
10 INT120237 Positive_regulation of Binding of Ncoa1 and Insrr 1 0.00 0.15 0.28 25.00
11 INT232174 GAN Positive_regulation of ODT 1 0.01 0.98 0.14 5.24
12 INT127128 Binding of CNR1 and CNR2 8 0.39 3.98 3.97 5.00
13 INT245332 ATR Regulation of IL6 1 0.03 0.35 0.17 5.00
14 INT273561 Binding of CYP1A1 and CYP3A4 1 0.02 0.12 0.15 5.00
15 INT245333 ATR Negative_regulation of Protein_catabolism of DCD 1 0.10 0.93 0.14 5.00
16 INT264085 CYP2C19 Regulation of CYP3A4 1 0.02 0 0.09 5.00
17 INT264103 Cyp2e1 Regulation of CYP2C9 1 0.04 0 0.09 5.00
18 INT264106 Cyp1a2 Regulation of CYP2D6 1 0.06 0 0.09 5.00
19 INT264104 Cyp1a2 Regulation of CYP2C9 1 0.04 0 0.09 5.00
20 INT264083 CYP2C19 Regulation of CYP2D6 1 0.05 0 0.09 5.00
21 INT264084 CYP2C19 Regulation of CYP2C9 1 0.03 0 0.09 5.00
22 INT264102 Cyp1a2 Regulation of CYP3A4 1 0.03 0 0.09 5.00
23 INT264107 Cyp2e1 Regulation of CYP2D6 1 0.05 0 0.09 5.00
24 INT264105 Cyp2e1 Regulation of CYP3A4 1 0.02 0 0.09 5.00
25 INT245329 ATR Negative_regulation of DCD 1 0.10 0.91 0.05 5.00
26 INT245331 ATR Regulation of IL1B 1 0.03 0.91 0.05 5.00
27 INT245330 ATR Regulation of TNF 1 0.04 0.9 0.05 5.00
28 INT241536 Binding of Abcb1b and Abcg2 1 0.10 0.17 0.04 5.00
29 INT315868 Vhl Positive_regulation of Transcription of PDGFA 1 0.00 1.39 0 5.00
30 INT315856 FLT3 Positive_regulation of Gene_expression of PDGFA 1 0.01 1.15 0 5.00
31 INT355201 Binding of HDAC9 and Gopc 1 0.01 0.06 0 5.00
32 INT241535 Abl1 Regulation of Positive_regulation of Jak2 1 0.10 0.53 0 5.00
33 INT178861 Binding of BAX and BCL2 3 0.27 3.07 0 5.00
34 INT315889 Binding of B4GALNT1 and IKBKAP 1 0.00 0.68 0 5.00
35 INT241537 Negative_regulation of Binding of Abl1 and Src 1 0.04 0.14 0 5.00
36 INT241539 Binding of Abl1 and Lyn 1 0.09 0.14 0 5.00
37 INT315867 Vhl Positive_regulation of Transcription of VEGFA 1 0.01 1.39 0 5.00
38 INT241534 Binding of Abl1 and Src 1 0.04 0.14 0 5.00
39 INT241538 Negative_regulation of Binding of Abl1 and Lyn 1 0.11 0.14 0 5.00

Single Events

The table below shows the top 200 pain related interactions that have been reported for Antiemetics. They are ordered first by their pain relevance and then by number of times they were reported in Antiemetics. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT51072 Positive_regulation of Positive_regulation of Htr3a 10 0.49 1.84 4.53 100.00
2 INT284059 Positive_regulation of Vsnl1 4 0.22 5.18 0.38 99.80
3 INT95538 Localization of CYP2D6 21 0.81 5.69 4.73 99.78
4 INT125377 Localization of CYP2B6 5 0.78 0.59 2.23 99.78
5 INT57483 Localization of 5-HT3C2 1 0.34 0.08 0.39 99.70
6 INT16569 Negative_regulation of HTR3A 14 0.57 6.91 4.42 99.50
7 INT212292 Binding of Vsnl1 2 0.18 5.18 0.61 99.44
8 INT2040 Positive_regulation of CYP2B6 95 0.69 34.3 25.6 99.40
9 INT10798 Positive_regulation of CYP2D6 24 0.56 5.82 11.31 99.40
10 INT53547 Binding of TACR1 22 0.48 5.03 9.48 99.22
11 INT647 Gene_expression of SGCG 211 0.75 78.46 55.82 98.88
12 INT164696 Localization of Depmq1 3 0.01 1.46 3.76 98.04
13 INT11077 Positive_regulation of Htr3a 63 0.67 15.61 22.7 97.52
14 INT17275 Gene_expression of HIVEP1 267 0.75 232.07 24.06 97.36
15 INT7715 Regulation of Drd2 35 0.62 10.79 22.3 97.32
16 INT65125 Gene_expression of Tacr1 81 0.77 23.9 38.35 97.20
17 INT180185 Gene_expression of MGMT 22 0.65 15.02 1.57 97.20
18 INT667 Negative_regulation of Hrh2 38 0.58 18.11 18.01 95.88
19 INT1898 Regulation of Crh 220 0.62 61.33 102.64 95.72
20 INT9230 Gene_expression of Htr3a 43 0.78 10.54 18.81 95.72
21 INT9069 Regulation of Htr3a 29 0.60 6.18 16.55 95.72
22 INT20455 Positive_regulation of Bche 15 0.59 7.22 3.7 94.52
23 INT57596 Regulation of Gene_expression of ALB 9 0.44 5.44 0.91 93.08
24 INT3758 Gene_expression of ALB 326 0.78 184.65 38.75 92.44
25 INT305070 Negative_regulation of Binding of TAC1 2 0.41 1.94 0.36 91.44
26 INT5501 Regulation of Oprd1 283 0.62 55.1 249.9 91.20
27 INT8779 Binding of TAC1 50 0.47 11.19 25.57 90.92
28 INT124185 Negative_regulation of Kit 57 0.59 35.43 3.61 90.32
29 INT151449 Negative_regulation of Gene_expression of Kit 18 0.45 12.05 2.23 90.32
30 INT91891 Gene_expression of Kit 268 0.78 158.89 22.67 89.76
31 INT85145 Negative_regulation of Cnr2 10 0.44 4.1 6.75 88.00
32 INT155590 Gene_expression of ARIH1 8 0.58 10.76 0.24 86.96
33 INT336719 Regulation of Gene_expression of ARIH1 1 0.23 1.83 0.11 86.96
34 INT10442 Negative_regulation of CNR1 47 0.59 20.88 20.2 86.64
35 INT157666 Positive_regulation of GOPC 335 0.60 120.19 42.75 86.08
36 INT70979 Binding of SNORD1C 1 0.14 0.08 0.12 84.80
37 INT232176 Regulation of Slc43a1 2 0.11 1.51 1.22 82.88
38 INT60779 Negative_regulation of CYP3A 63 0.59 8.38 21.27 82.68
39 INT1724 Negative_regulation of ACE 437 0.59 315.64 74.48 81.12
40 INT232177 Gene_expression of Slc43a1 2 0.04 1.06 0.4 80.52
41 INT85144 Binding of Cnr2 14 0.47 6.41 9.49 79.96
42 INT67474 Negative_regulation of B3GAT1 9 0.57 5.43 3.73 79.88
43 INT56870 Gene_expression of CYP2D6 87 0.78 8.83 37.53 78.08
44 INT232181 Positive_regulation of ODT 1 0.12 2.44 1.1 76.12
45 INT145 Negative_regulation of H1 12 0.39 5.68 5.08 75.60
46 INT50405 Negative_regulation of CYP3A4 238 0.59 53.65 51.51 75.04
47 INT18190 Regulation of DRD2 11 0.60 9.01 7.63 75.00
48 INT27387 Binding of Aecp 4 0.34 5.09 1 73.68
49 INT232180 Positive_regulation of Slc43a1 2 0.09 1.79 0.98 73.40
50 INT232179 Binding of Slc43a1 1 0.02 1.21 0.43 73.40
51 INT65009 Gene_expression of HTR3A 29 0.75 8.51 10.59 72.96
52 INT21685 Gene_expression of ras 115 0.66 85.6 7.76 72.96
53 INT26545 Gene_expression of Hras1 173 0.78 79.54 13.21 72.88
54 INT93129 Negative_regulation of KCNH2 42 0.54 9.63 10.85 72.08
55 INT4403 Binding of CYP2B6 113 0.48 21.17 33.83 71.04
56 INT50580 Binding of PPIG 39 0.36 11.17 12.34 71.04
57 INT22211 Positive_regulation of CYP3A4 110 0.70 22 28.27 68.84
58 INT16268 Binding of HTR3A 15 0.47 7.38 7.18 68.24
59 INT152223 Binding of BEST1 10 0.29 6.67 1.46 67.16
60 INT74464 Binding of GNPTAB 9 0.17 3.32 1.17 66.32
61 INT65286 Binding of ARIH1 10 0.48 4.3 0.76 66.32
62 INT6302 Binding of IFNA1 196 0.48 133.85 32.73 65.72
63 INT67855 Negative_regulation of PPIG 64 0.57 17.83 13.54 65.56
64 INT60764 Positive_regulation of PPIG 39 0.67 17.08 13.48 65.00
65 INT5058 Positive_regulation of IFNA1 356 0.70 245.75 60.52 64.92
66 INT10796 Gene_expression of CYP2B6 131 0.77 30.14 35.27 64.64
67 INT70877 Gene_expression of PPIG 72 0.75 22.39 10.93 64.64
68 INT199744 Regulation of REV1 2 0.16 0.91 0.27 63.96
69 INT8571 Gene_expression of B3GAT1 54 0.75 36.85 15.98 62.88
70 INT212293 Gene_expression of Vsnl1 14 0.29 8.1 0.61 62.04
71 INT346054 Positive_regulation of Gene_expression of Vsnl1 1 0.22 1.13 0.11 62.04
72 INT346055 Negative_regulation of Gene_expression of Vsnl1 1 0.18 0.99 0.06 62.04
73 INT184749 Gene_expression of Car9 9 0.31 9.45 0.14 57.80
74 INT336718 Positive_regulation of Localization of ARIH1 1 0.22 0.94 0.09 54.64
75 INT281839 Localization of ARIH1 2 0.54 3.03 0.09 54.32
76 INT3060 Negative_regulation of Bche 94 0.59 46.75 18.51 52.88
77 INT57549 Gene_expression of GNPTAB 49 0.65 57.5 9.05 52.72
78 INT320680 Regulation of Gene_expression of GNPTAB 2 0.32 2.14 0.09 52.72
79 INT1200 Negative_regulation of Ins1 274 0.58 155.17 56.14 52.56
80 INT232182 Regulation of ODT 1 0.07 1.07 0.46 51.60
81 INT12608 Regulation of CNR1 62 0.60 24.36 36.02 43.88
82 INT5497 Positive_regulation of Crh 299 0.70 125.54 131.14 42.08
83 INT5137 Binding of PCa 45 0.47 16.91 18.47 38.96
84 INT23647 Negative_regulation of CDA 3 0.38 1.48 0.08 38.40
85 INT12762 Negative_regulation of Positive_regulation of Ins1 24 0.59 8.51 8.28 37.72
86 INT144021 Binding of Pdgfrb 9 0.37 5.53 0.28 37.68
87 INT70017 Positive_regulation of BCL2 87 0.67 66.62 8.68 37.12
88 INT73596 Positive_regulation of Gene_expression of BAX 43 0.67 40.97 9.22 36.88
89 INT65959 Positive_regulation of Gene_expression of BCL2 75 0.70 77.3 8.27 36.88
90 INT171364 Localization of Pdgfrb 6 0.37 4.98 0.68 36.84
91 INT70884 Localization of Pdgfb 8 0.35 6.22 0.42 36.84
92 INT1472 Positive_regulation of Ins1 349 0.69 146.2 86.36 36.68
93 INT65960 Gene_expression of BCL2 352 0.78 312.03 30.73 36.24
94 INT230487 Positive_regulation of KIDINS220 1 0.10 0.63 0 35.92
95 INT27170 Gene_expression of Maoa 13 0.67 3.88 7.5 34.64
96 INT73593 Gene_expression of BAX 173 0.76 147.81 20.94 34.12
97 INT3593 Gene_expression of ADRA1D 70 0.75 29.48 20.87 29.20
98 INT6521 Negative_regulation of Gene_expression of ADRA1D 4 0.57 3.19 2.14 29.20
99 INT84389 Transcription of HTR3A 2 0.69 0.3 0.94 28.40
100 INT284058 Negative_regulation of Vsnl1 2 0.21 1.95 0.09 27.76
101 INT175738 Regulation of ARNTL 4 0.28 0.29 0 26.28
102 INT76660 Gene_expression of Trpv1 691 0.78 329.46 386.42 25.00
103 INT2451 Positive_regulation of Avp 355 0.70 102.66 147.69 25.00
104 INT9852 Positive_regulation of Gpt 563 0.70 364.64 146.82 25.00
105 INT425 Localization of PRL 455 0.81 189.64 144.8 25.00
106 INT915 Positive_regulation of PRL 342 0.70 141.96 104.31 25.00
107 INT98621 Regulation of Trpv1 121 0.62 79.24 75.23 25.00
108 INT4153 Binding of Insrr 109 0.40 17.99 72.15 25.00
109 INT7344 Gene_expression of TAC1 132 0.75 35.48 68.26 25.00
110 INT96622 Localization of Trpv1 110 0.81 59.82 63.25 25.00
111 INT6894 Gene_expression of CNR1 168 0.78 74.07 62.84 25.00
112 INT5017 Negative_regulation of Tacr1 76 0.58 17 57.07 25.00
113 INT1579 Gene_expression of PRL 279 0.78 119.2 55.41 25.00
114 INT37219 Gene_expression of TACR1 56 0.78 32.4 54.16 25.00
115 INT50334 Negative_regulation of Cnr1 84 0.58 30.86 51.75 25.00
116 INT76620 Gene_expression of Cnr2 93 0.78 34.7 50.14 25.00
117 INT2604 Positive_regulation of Got1 223 0.70 154.78 49.51 25.00
118 INT8713 Regulation of Tac1 56 0.60 25.29 45.94 25.00
119 INT63383 Binding of Cnr1 77 0.48 22.28 44.61 25.00
120 INT2364 Localization of Sct 134 0.80 26.21 41.47 25.00
121 INT918 Positive_regulation of Localization of PRL 90 0.70 23.97 40.3 25.00
122 INT4925 Binding of Tacr1 57 0.48 17.39 38.38 25.00
123 INT3913 Positive_regulation of ABAT 47 0.69 22.73 33.4 25.00
124 INT10797 Binding of CYP2D6 86 0.48 15.09 31.16 25.00
125 INT719 Negative_regulation of SGCG 96 0.57 47.91 30.22 25.00
126 INT111359 Localization of Cnr1 55 0.81 11.25 27.41 25.00
127 INT92105 Transcription of Trpv1 47 0.71 27.47 25.01 25.00
128 INT12484 Binding of Drd2 45 0.48 15.17 24.72 25.00
129 INT6270 Binding of HTR1D 55 0.47 9.54 22.86 25.00
130 INT49774 Binding of DRD2 48 0.48 17.42 20.73 25.00
131 INT1703 Regulation of PCa 52 0.52 23.65 20.6 25.00
132 INT79955 Localization of Cnr1 26 0.81 8.44 19.06 25.00
133 INT4420 Positive_regulation of GOT1 103 0.64 88.4 18.38 25.00
134 INT3400 Positive_regulation of pr 57 0.68 36.9 16.24 25.00
135 INT1706 Negative_regulation of PCa 33 0.47 10.7 15.27 25.00
136 INT505 Positive_regulation of GPT 89 0.67 69.38 14.94 25.00
137 INT2005 Positive_regulation of Gene_expression of PRL 55 0.70 21.4 13.44 25.00
138 INT9231 Binding of Htr3a 27 0.47 7.29 13.04 25.00
139 INT12369 Negative_regulation of Htr3a 28 0.59 8.78 12.62 25.00
140 INT71189 Gene_expression of Cyp1a2 24 0.78 11.39 11.12 25.00
141 INT15262 Negative_regulation of Positive_regulation of Avp 22 0.58 3.28 10.81 25.00
142 INT3851 Gene_expression of Got1 58 0.65 29.15 10.52 25.00
143 INT49205 Positive_regulation of B3GAT1 20 0.67 10.28 8.71 25.00
144 INT34268 Binding of WAS 14 0.47 4.41 8.67 25.00
145 INT2367 Binding of Sct 34 0.42 8.46 8.62 25.00
146 INT9966 Localization of Htr3a 14 0.80 2.28 7.92 25.00
147 INT96724 Gene_expression of Cyp3a11 10 0.77 4.82 7.76 25.00
148 INT83952 Gene_expression of Cxadr 24 0.75 22.38 6.77 25.00
149 INT12333 Regulation of CYP3A 18 0.62 2.25 6.74 25.00
150 INT16568 Positive_regulation of HTR3A 14 0.67 4.82 6.01 25.00
151 INT62835 Binding of HTR1F 12 0.47 2 5.43 25.00
152 INT119203 Gene_expression of CXADR 64 0.74 11.37 4.41 25.00
153 INT148671 Gene_expression of Aip 26 0.63 24.32 3.91 25.00
154 INT71199 Positive_regulation of Gene_expression of Cyp1a2 4 0.69 1.41 3.36 25.00
155 INT78189 Positive_regulation of Htr3a 6 0.67 0.78 3.14 25.00
156 INT45112 Positive_regulation of PRB1 20 0.60 6.49 2.85 25.00
157 INT120234 Positive_regulation of Gene_expression of Cyp3a11 4 0.46 2.21 2.13 25.00
158 INT104220 Positive_regulation of Gene_expression of PPIG 14 0.49 7.38 1.7 25.00
159 INT119010 Binding of IGKV2D-26 3 0.36 2.69 1.6 25.00
160 INT120227 Binding of Cxadr 17 0.45 8.02 1.51 25.00
161 INT109272 Negative_regulation of Binding of DRD2 2 0.36 0.76 1.26 25.00
162 INT113865 Binding of CXADR 35 0.46 3.18 1.12 25.00
163 INT120232 Gene_expression of Nr1i3 4 0.75 1.08 0.84 25.00
164 INT41536 Localization of ANTXR1 7 0.60 2.24 0.79 25.00
165 INT77927 Negative_regulation of Gene_expression of Cyp1a2 3 0.42 1.23 0.78 25.00
166 INT120224 Gene_expression of Cyp20a1 2 0.21 0.5 0.72 25.00
167 INT120226 Positive_regulation of Cxadr 4 0.44 2.54 0.48 25.00
168 INT57484 Gene_expression of 5-HT3C2 1 0.30 0.19 0.47 25.00
169 INT163516 Negative_regulation of Positive_regulation of PRB1 1 0.15 0.08 0.45 25.00
170 INT120229 Binding of Ncoa1 6 0.35 1.04 0.44 25.00
171 INT120235 Negative_regulation of Gene_expression of PPIG 4 0.41 0.92 0.43 25.00
172 INT47254 Negative_regulation of Gm5338 1 0.28 0 0.37 25.00
173 INT61903 Negative_regulation of Slc43a1 3 0.34 2.18 0.3 25.00
174 INT120230 Negative_regulation of Gene_expression of Cyp3a11 1 0.30 0.17 0.29 25.00
175 INT109269 Binding of Gm9705 1 0.07 0.25 0.29 25.00
176 INT120231 Negative_regulation of Gene_expression of Cyp20a1 1 0.11 0.17 0.29 25.00
177 INT120228 Positive_regulation of Gene_expression of Cyp20a1 1 0.13 0.17 0.29 25.00
178 INT109270 Negative_regulation of Binding of Gm9705 1 0.09 0.25 0.29 25.00
179 INT120225 Positive_regulation of Gene_expression of Nr1i3 1 0.67 0.16 0.28 25.00
180 INT164226 Regulation of TBX3 1 0.23 0.57 0.26 25.00
181 INT58879 Negative_regulation of Localization of ANTXR1 2 0.35 0.55 0.22 25.00
182 INT120233 Binding of Nr1i3 1 0.47 0.09 0.19 25.00
183 INT138242 Positive_regulation of Cd46 1 0.41 0 0.05 25.00
184 INT138241 Gene_expression of Cd46 1 0.67 0.24 0 25.00
185 INT397 Localization of SST 232 0.81 58.05 101.19 23.88
186 INT62487 Localization of HIVEP1 35 0.73 36.24 2.72 23.28
187 INT203932 Regulation of Localization of HIVEP1 2 0.38 1.69 0.03 23.28
188 INT158581 Negative_regulation of Positive_regulation of CYP3A4 7 0.43 1.83 0.29 21.60
189 INT134902 Positive_regulation of Tymp 11 0.37 3.06 0.53 21.52
190 INT93490 Gene_expression of GPM6A 14 0.69 3.14 9.08 20.72
191 INT4004 Gene_expression of IGHG3 321 0.71 221.03 42.33 20.00
192 INT50579 Binding of CYP3A4 84 0.48 17.52 17.45 13.12
193 INT325077 Positive_regulation of OR4G3P 1 0.29 0.96 0.27 12.64
194 INT31580 Negative_regulation of Cyp11a1 14 0.57 3.48 3.61 11.64
195 INT1705 Gene_expression of pCA 126 0.65 88.65 34.81 10.00
196 INT1704 Positive_regulation of PCa 68 0.59 34.92 23.36 10.00
197 INT107129 Positive_regulation of RLS 46 0.60 40.1 8.09 10.00
198 INT12334 Positive_regulation of CYP3A 34 0.70 6.77 7.85 10.00
199 INT77955 Negative_regulation of PCS 55 0.43 39.32 5.76 10.00
200 INT69314 Binding of CYP3A 16 0.48 1.78 2.19 10.00
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