P:Antiepileptic agent

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Pain Term
Category Drug class
Synonyms Antiepileptic Agents
Pain Specific No
Documents 114
Hot Single Events 9
Hot Interactions 0

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported for Antiepileptic agent. They are ordered first by their pain relevance and then by number of times they were reported for Antiepileptic agent. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT262336 Binding of Abat and Tmem132a 1 0.00 1.39 1.14 44.96
2 INT142847 IRF6 Positive_regulation of IL6 5 0.07 1.09 0.73 5.00
3 INT64956 IRF6 Positive_regulation of Gene_expression of IL6 4 0.19 1.4 0.63 5.00
4 INT335291 SLC15A4 Negative_regulation of NFATC1 1 0.01 0.45 0.51 5.00
5 INT335307 SLC15A4 Regulation of TIMP1 1 0.01 0.69 0.29 5.00
6 INT262354 TRIP10 Negative_regulation of Cyp4a3 1 0.00 0.8 0.26 5.00
7 INT262353 TRIP10 Negative_regulation of Cyp1a2 1 0.03 0.8 0.26 5.00
8 INT262329 TRIP10 Negative_regulation of CYP2C19 1 0.01 0.8 0.26 5.00
9 INT262330 Positive_regulation of TRIP10 Negative_regulation of CYP2C19 1 0.01 0.8 0.26 5.00
10 INT335346 SLC15A4 Negative_regulation of Gene_expression of Fos 1 0.02 0.23 0.23 5.00
11 INT335299 IRF6 Positive_regulation of TIMP1 1 0.03 0.21 0.19 5.00
12 INT335298 IRF6 Positive_regulation of MMP9 1 0.01 0.21 0.19 5.00
13 INT335311 Binding of IRF6 and SLC15A4 1 0.00 0.23 0.19 5.00
14 INT335306 IRF6 Positive_regulation of MMP3 1 0.03 0.21 0.18 5.00
15 INT335304 IRF6 Positive_regulation of Gene_expression of MMP1 1 0.01 0.21 0.18 5.00
16 INT335302 IRF6 Positive_regulation of MMP1 1 0.01 0.21 0.18 5.00
17 INT266899 Binding of Prkca and Plat 1 0.02 0.57 0.17 5.00
18 INT335300 SLC15A4 Regulation of CA2 1 0.00 0.19 0.12 5.00
19 INT335293 SLC15A4 Regulation of NA 1 0.00 0.19 0.12 5.00
20 INT266904 Plat Positive_regulation of Positive_regulation of Mapk8 1 0.03 0.6 0.11 5.00
21 INT266900 Gene_expression of Sod2 Negative_regulation of Gene_expression of Sod1 1 0.11 0.41 0.11 5.00
22 INT252421 Gja1 Regulation of P2ry1 1 0.00 0.28 0.09 5.00
23 INT262335 Binding of Sv2a and Bri3 1 0.01 0.71 0.08 5.00
24 INT174133 Binding of Igfals and Sod1 3 0.19 3 0.08 5.00
25 INT266902 Nfe2l2 Positive_regulation of Sod2 1 0.16 0.19 0.04 5.00
26 INT266901 Nfe2l2 Positive_regulation of Cat 1 0.10 0.19 0.04 5.00
27 INT266897 Nfe2l2 Positive_regulation of Sod1 1 0.11 0.19 0.04 5.00
28 INT266898 Gtf3a Positive_regulation of Sod2 1 0.00 0 0.04 5.00
29 INT335289 IRF6 Positive_regulation of Gene_expression of TIMP1 1 0.03 0.16 0.04 5.00
30 INT266903 Binding of Sod2 and Trp53 1 0.05 0 0.03 5.00
31 INT335303 Binding of IRF6 and MMP2 1 0.01 0 0 5.00
32 INT335312 SLC15A4 Negative_regulation of TIMP1 1 0.01 0.07 0 5.00
33 INT335295 SLC15A4 Negative_regulation of MMP9 1 0.00 0.07 0 5.00
34 INT335309 IRF6 Positive_regulation of Gene_expression of MMP3 1 0.03 0.07 0 5.00
35 INT335292 IRF6 Positive_regulation of Localization of MMP1 1 0.01 0.06 0 5.00
36 INT335305 SLC15A4 Negative_regulation of MMP3 1 0.01 0.07 0 5.00
37 INT335288 SLC15A4 Negative_regulation of IRF6 Positive_regulation of MMP9 1 0.00 0.07 0 5.00
38 INT335301 Binding of MMP2 and SLC15A4 1 0.00 0 0 5.00
39 INT335310 SLC15A4 Negative_regulation of Gene_expression of MMP1 1 0.00 0.07 0 5.00
40 INT335290 SLC15A4 Positive_regulation of Localization of MMP1 1 0.00 0.06 0 5.00
41 INT335297 IRF6 Positive_regulation of Gene_expression of MMP2 1 0.01 0.07 0 5.00
42 INT335308 SLC15A4 Negative_regulation of MMP1 1 0.00 0.07 0 5.00
43 INT335296 IRF6 Positive_regulation of Localization of SLC15A4 1 0.00 0.06 0 5.00
44 INT335294 IRF6 Positive_regulation of Gene_expression of MMP9 1 0.01 0.07 0 5.00

Single Events

The table below shows the top 200 pain related interactions that have been reported for Antiepileptic agent. They are ordered first by their pain relevance and then by number of times they were reported in Antiepileptic agent. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT1652 Regulation of Pomc 387 0.62 61.01 186.51 99.98
2 INT5513 Negative_regulation of Pomc 295 0.59 60.9 158.63 99.72
3 INT1004 Regulation of Sst 140 0.62 18.52 94.84 95.44
4 INT3755 Positive_regulation of GBE1 29 0.40 8.99 8.91 95.12
5 INT51530 Negative_regulation of Adk 11 0.56 3.83 9.07 93.60
6 INT170025 Gene_expression of Fig4 588 0.67 183.27 113.32 87.88
7 INT49813 Gene_expression of Ptz1a 5 0.49 2.8 2.39 84.48
8 INT2211 Negative_regulation of Abat 267 0.59 66.51 200.98 80.72
9 INT2480 Negative_regulation of Got1 43 0.51 14.47 16.09 80.72
10 INT50581 Regulation of PPIG 26 0.55 8.96 4.32 79.48
11 INT55418 Regulation of CYP2D6 29 0.61 1.83 10.21 79.48
12 INT68372 Regulation of CYP2C9 28 0.62 5.64 9.53 79.48
13 INT63057 Regulation of CYP3A4 31 0.61 5.75 6.92 79.48
14 INT55419 Regulation of CYP1A2 19 0.62 5.3 4.75 79.48
15 INT28188 Regulation of CYP2E1 11 0.62 0.48 2.03 79.48
16 INT72558 Regulation of CYP2C19 6 0.54 1.97 1.14 79.48
17 INT72924 Negative_regulation of MCRS1 27 0.19 33.59 10.29 79.16
18 INT2651 Positive_regulation of Pomc 403 0.70 95.72 206.24 75.00
19 INT15643 Positive_regulation of Positive_regulation of Pomc 30 0.65 4.59 15.34 75.00
20 INT12129 Gene_expression of CYP3A4 107 0.78 23.11 27.6 75.00
21 INT65881 Gene_expression of CYP2C19 21 0.76 1.19 4.57 75.00
22 INT70878 Gene_expression of CYP2A6 17 0.75 4.25 2.02 75.00
23 INT79780 Gene_expression of Cyp4a3 14 0.56 5.19 1.12 75.00
24 INT79779 Negative_regulation of LOC690147 1 0.06 0 0.17 75.00
25 INT25104 Regulation of Ptz1a 4 0.38 2.44 2 71.88
26 INT148671 Gene_expression of Aip 26 0.63 24.32 3.91 70.72
27 INT113948 Gene_expression of FLNA 32 0.73 36.06 4.81 68.72
28 INT22211 Positive_regulation of CYP3A4 110 0.70 22 28.27 67.80
29 INT50403 Negative_regulation of CYP2C19 55 0.59 8.97 17.79 66.40
30 INT6034 Binding of Gabrg1 115 0.47 17.48 51.92 65.76
31 INT61963 Gene_expression of Gjd2 2 0.42 0.39 0.8 62.92
32 INT152629 Positive_regulation of Bid 6 0.46 6.74 1.78 62.64
33 INT8764 Positive_regulation of Positive_regulation of Cyp3a23/3a1 5 0.45 1.62 3.33 59.92
34 INT8766 Positive_regulation of Positive_regulation of CYP2B6 5 0.49 3.41 1.97 59.92
35 INT211228 Localization of Serpind1 3 0.63 6.11 0.51 58.56
36 INT184890 Regulation of MCRS1 35 0.22 44.35 13.78 54.80
37 INT2040 Positive_regulation of CYP2B6 95 0.69 34.3 25.6 54.48
38 INT11934 Regulation of Sv2a 4 0.44 1.72 1.1 54.24
39 INT61962 Transcription of Cacna2d2 1 0.03 0 0.63 53.04
40 INT8765 Positive_regulation of Cyp3a23/3a1 63 0.67 22.28 20.39 52.64
41 INT49263 Binding of Grip2 31 0.41 9.86 16.38 50.40
42 INT4403 Binding of CYP2B6 113 0.48 21.17 33.83 50.00
43 INT68559 Negative_regulation of Gli3 5 0.37 4.56 4.93 46.56
44 INT73010 Gene_expression of Tmem132a 8 0.77 4.38 8.86 44.96
45 INT26698 Positive_regulation of Cacna1a 37 0.67 26.33 39.1 42.40
46 INT49110 Regulation of Grip2 46 0.61 13.57 30.87 39.52
47 INT123787 Gene_expression of Bid 25 0.66 16 6.35 39.28
48 INT57368 Regulation of ADHD1 39 0.50 42.23 5.01 36.96
49 INT216977 Gene_expression of Lpar4 7 0.35 3.93 1.66 30.60
50 INT75105 Gene_expression of SLC15A4 3 0.19 3.33 0.74 25.40
51 INT335321 Positive_regulation of Gene_expression of SLC15A4 1 0.03 1.02 0.24 25.40
52 INT7581 Binding of ADHD1 132 0.46 135.1 19.73 23.92
53 INT64161 Positive_regulation of Prkca 213 0.70 85.06 129.91 16.80
54 INT137980 Positive_regulation of P2RX7 30 0.67 22.49 10 12.88
55 INT64159 Gene_expression of Prkca 90 0.78 34.65 55.97 12.56
56 INT76469 Positive_regulation of Gene_expression of Prkca 18 0.46 7.9 13.36 12.56
57 INT3537 Positive_regulation of Car2 413 0.56 103.51 94.35 11.40
58 INT17561 Localization of Car2 303 0.79 60.95 44.52 10.44
59 INT3439 Localization of Abat 1017 0.78 112.39 727.06 5.00
60 INT9238 Gene_expression of IL6 1575 0.78 1135.66 424.22 5.00
61 INT162 Regulation of Prl 794 0.62 165.01 322.24 5.00
62 INT5379 Gene_expression of Fos 656 0.78 255.5 292.54 5.00
63 INT68684 Gene_expression of VEGFA 2371 0.78 1742.52 259.2 5.00
64 INT2909 Positive_regulation of Abat 334 0.70 62.1 256.43 5.00
65 INT9987 Gene_expression of Abat 296 0.78 95.46 226.34 5.00
66 INT2910 Regulation of Abat 169 0.62 36.95 153.53 5.00
67 INT4829 Positive_regulation of Localization of Abat 199 0.55 20.91 150.48 5.00
68 INT5380 Positive_regulation of Gene_expression of Fos 243 0.70 105.65 131.05 5.00
69 INT695 Binding of POMC 304 0.48 56.66 126.85 5.00
70 INT11051 Positive_regulation of Gene_expression of IL6 415 0.69 319.21 109.3 5.00
71 INT90091 Gene_expression of GOPC 967 0.67 366.22 103.6 5.00
72 INT940 Negative_regulation of Ptgs1 219 0.59 104.34 95.97 5.00
73 INT10534 Positive_regulation of Trib3 209 0.60 78.75 81.48 5.00
74 INT2212 Binding of Abat 89 0.48 18.36 63.99 5.00
75 INT6623 Gene_expression of NA 231 0.78 45.78 59.36 5.00
76 INT1759 Gene_expression of TIMP1 267 0.77 133.87 59.29 5.00
77 INT48901 Negative_regulation of IL6 186 0.57 136.33 57.87 5.00
78 INT73048 Gene_expression of MMP9 268 0.77 159.75 57.81 5.00
79 INT48232 Gene_expression of MMP1 245 0.78 96.31 57.72 5.00
80 INT19 Regulation of Gnrhr 131 0.62 36.4 55.66 5.00
81 INT8528 Negative_regulation of Gene_expression of Fos 100 0.59 41.15 55.6 5.00
82 INT69876 Negative_regulation of Nfkb1 147 0.58 89.81 55.5 5.00
83 INT62543 Gene_expression of Icam1 231 0.78 187.58 52.71 5.00
84 INT9210 Regulation of IL6 166 0.62 125.61 49.95 5.00
85 INT26500 Gene_expression of MMP2 201 0.78 110.57 46.9 5.00
86 INT20492 Gene_expression of MMP12 89 0.76 81.36 46.12 5.00
87 INT52531 Gene_expression of Nfkb1 153 0.75 82.84 42.9 5.00
88 INT29496 Gene_expression of MMP3 136 0.75 49.49 41.78 5.00
89 INT12228 Positive_regulation of Gene_expression of Abat 44 0.65 17.51 40.55 5.00
90 INT12892 Negative_regulation of TIMP1 136 0.58 83.13 36.54 5.00
91 INT9239 Regulation of Gene_expression of IL6 106 0.61 75.24 36.53 5.00
92 INT6943 Positive_regulation of Gabrd 71 0.70 17.36 35.25 5.00
93 INT666 Gene_expression of Jun 124 0.78 54.61 33.67 5.00
94 INT96913 Positive_regulation of Mapk8 179 0.69 130.44 32.2 5.00
95 INT73982 Gene_expression of Hmox1 141 0.78 119.43 32.17 5.00
96 INT64164 Regulation of Prkca 34 0.62 10.44 30.99 5.00
97 INT15610 Localization of GOPC 223 0.65 68.26 28.7 5.00
98 INT17825 Gene_expression of Flvcr2 44 0.68 12.58 28.08 5.00
99 INT22045 Gene_expression of IRF6 158 0.75 58.07 27.81 5.00
100 INT177581 Regulation of Fig4 113 0.41 39.26 27.75 5.00
101 INT2912 Positive_regulation of Positive_regulation of Abat 29 0.66 6.48 27.54 5.00
102 INT64499 Positive_regulation of IRF6 123 0.49 52.73 27.51 5.00
103 INT73047 Positive_regulation of MMP9 133 0.68 73.22 26.42 5.00
104 INT63444 Regulation of Gene_expression of Abat 26 0.51 14.65 26.29 5.00
105 INT56524 Gene_expression of Grip2 67 0.74 14.77 26.23 5.00
106 INT73670 Gene_expression of Vcam1 128 0.78 123.79 24.96 5.00
107 INT72370 Gene_expression of Timp1 82 0.65 57.52 24.16 5.00
108 INT66758 Binding of Nfkb1 97 0.48 50.65 23.65 5.00
109 INT16721 Negative_regulation of Cat 56 0.59 44.44 22.84 5.00
110 INT34488 Negative_regulation of MMP2 85 0.59 41.98 21.72 5.00
111 INT10536 Gene_expression of Trib3 67 0.66 27.08 21.58 5.00
112 INT117527 Binding of Prkca 25 0.48 6.43 21.05 5.00
113 INT1561 Negative_regulation of Dnahc8 59 0.59 18.12 20.99 5.00
114 INT97798 Localization of IRF6 86 0.73 33.27 20.94 5.00
115 INT31874 Negative_regulation of Gene_expression of Abat 31 0.42 12.22 20.31 5.00
116 INT51055 Positive_regulation of TIMP1 103 0.69 50.07 19.86 5.00
117 INT93663 Positive_regulation of MMP1 72 0.67 33.38 19.86 5.00
118 INT101188 Gene_expression of Rela 81 0.56 23.43 19.15 5.00
119 INT171060 Gene_expression of PDX1 72 0.75 72.57 17.97 5.00
120 INT80223 Positive_regulation of Hmox1 128 0.68 77.71 17.64 5.00
121 INT111416 Positive_regulation of Trpm8 65 0.70 14.62 17.13 5.00
122 INT62546 Positive_regulation of Gene_expression of Icam1 60 0.70 59.52 16.9 5.00
123 INT26314 Positive_regulation of MMP3 48 0.67 22.14 16.17 5.00
124 INT56447 Positive_regulation of Icam1 64 0.64 64.14 16.16 5.00
125 INT103245 Positive_regulation of Gene_expression of MMP9 64 0.68 36.86 15.7 5.00
126 INT5536 Regulation of NA 74 0.59 16.61 15.36 5.00
127 INT103210 Localization of MMP1 43 0.78 12.15 15.13 5.00
128 INT12891 Negative_regulation of MMP3 41 0.58 17.99 15.06 5.00
129 INT79227 Negative_regulation of Gene_expression of Icam1 45 0.59 41.65 14.97 5.00
130 INT88544 Gene_expression of MMRN1 102 0.75 68.8 14.55 5.00
131 INT92823 Positive_regulation of Gene_expression of MMP1 65 0.68 25.69 14.31 5.00
132 INT72127 Protein_catabolism of MMRN1 68 0.52 56 14.13 5.00
133 INT80228 Positive_regulation of Gene_expression of Hmox1 68 0.70 62.88 14.01 5.00
134 INT1758 Positive_regulation of Gene_expression of TIMP1 62 0.69 31.72 13.98 5.00
135 INT34904 Negative_regulation of Gtf3a 48 0.15 38.88 13.73 5.00
136 INT67653 Gene_expression of Om 46 0.36 15.28 13.32 5.00
137 INT99586 Binding of IRF6 60 0.36 27.87 13.2 5.00
138 INT31990 Positive_regulation of SOD1 124 0.69 67.79 12.52 5.00
139 INT158124 Gene_expression of COL5A2 136 0.69 72.3 12.44 5.00
140 INT14510 Gene_expression of SOD1 208 0.76 88.56 12.4 5.00
141 INT80790 Positive_regulation of Flvcr2 22 0.45 4.92 12.35 5.00
142 INT15756 Positive_regulation of Gene_expression of Jun 29 0.69 16.58 12.06 5.00
143 INT184853 Gene_expression of ADHD1 87 0.65 89.2 11.8 5.00
144 INT93715 Negative_regulation of MMP9 69 0.55 36.05 11.73 5.00
145 INT170601 Positive_regulation of Gene_expression of GOPC 122 0.43 42.79 11.68 5.00
146 INT109315 Gene_expression of Mapk8 70 0.78 45.46 11.65 5.00
147 INT96915 Phosphorylation of Mapk8 73 0.81 40.69 11.44 5.00
148 INT70816 Negative_regulation of Fos 32 0.58 13 11.18 5.00
149 INT158070 Localization of Aes 23 0.65 19.93 10.9 5.00
150 INT8021 Gene_expression of Enpp1 43 0.78 31.46 10.8 5.00
151 INT3535 Regulation of CA2 61 0.32 16.48 10.8 5.00
152 INT118390 Positive_regulation of Nfe2l2 82 0.70 20.41 10.61 5.00
153 INT82950 Positive_regulation of Gdnf 36 0.51 11.72 10.5 5.00
154 INT17824 Positive_regulation of Gene_expression of Flvcr2 15 0.41 6.66 10.23 5.00
155 INT167964 Gene_expression of Aes 30 0.58 25.41 10.16 5.00
156 INT79720 Positive_regulation of Cat 57 0.70 31.81 10.11 5.00
157 INT107606 Negative_regulation of MMP1 38 0.42 11.94 10.01 5.00
158 INT53063 Positive_regulation of Slc1a1 10 0.70 3.23 9.89 5.00
159 INT145695 Regulation of Mapk8 26 0.62 14.67 9.83 5.00
160 INT126031 Negative_regulation of Gene_expression of MMP9 40 0.57 22.71 9.79 5.00
161 INT120509 Gene_expression of Cat 65 0.77 50.9 9.75 5.00
162 INT11729 Regulation of IGF1 71 0.61 44.58 9.71 5.00
163 INT102987 Regulation of MMP3 23 0.60 9.35 9.54 5.00
164 INT26502 Negative_regulation of Gene_expression of MMP2 39 0.58 21.45 9.42 5.00
165 INT149138 Binding of PDX1 27 0.37 32.62 9.33 5.00
166 INT61264 Regulation of Jun 36 0.61 18.42 8.71 5.00
167 INT71763 Gene_expression of Mri1 33 0.58 12.56 8.6 5.00
168 INT81444 Positive_regulation of Gene_expression of Vcam1 40 0.70 46.38 8.58 5.00
169 INT5359 Protein_catabolism of Abat 12 0.62 5.11 8.54 5.00
170 INT16460 Negative_regulation of PPBP 21 0.57 13.86 8.54 5.00
171 INT150422 Positive_regulation of Aes 24 0.43 15.63 8 5.00
172 INT67037 Gene_expression of Sod1 121 0.78 59.32 7.99 5.00
173 INT80220 Positive_regulation of Bcl2 71 0.58 57.73 7.86 5.00
174 INT124297 Gene_expression of Sod2 112 0.77 65.65 7.64 5.00
175 INT264027 Positive_regulation of Positive_regulation of Flvcr2 2 0.08 2.67 7.27 5.00
176 INT111056 Negative_regulation of Gene_expression of Flvcr2 9 0.13 4.15 7.18 5.00
177 INT43727 Negative_regulation of Gene_expression of MMP3 16 0.40 4.81 7.18 5.00
178 INT52132 Positive_regulation of Negative_regulation of Abat 9 0.50 0.53 7.03 5.00
179 INT21579 Negative_regulation of Gene_expression of TIMP1 25 0.57 12.41 6.94 5.00
180 INT14903 Negative_regulation of SOD1 81 0.57 42.02 6.91 5.00
181 INT52180 Binding of Aes 38 0.42 23.16 6.7 5.00
182 INT76096 Positive_regulation of Gene_expression of IRF6 37 0.49 14.24 6.39 5.00
183 INT81443 Positive_regulation of Vcam1 29 0.63 28.4 6.35 5.00
184 INT14560 Regulation of Igf1 41 0.59 19.59 6.3 5.00
185 INT127023 Negative_regulation of Gene_expression of Vcam1 24 0.59 20.39 6.28 5.00
186 INT88326 Negative_regulation of P2rx7 16 0.58 8.77 6.25 5.00
187 INT95607 Regulation of MMP1 19 0.60 7.86 6.18 5.00
188 INT95313 Gene_expression of Slc6a1 6 0.76 3.96 6.14 5.00
189 INT157932 Positive_regulation of ADHD1 46 0.48 52.18 6.13 5.00
190 INT108628 Regulation of MMP2 27 0.60 14.85 6.06 5.00
191 INT88873 Negative_regulation of Gene_expression of Nfkb1 24 0.56 9.93 5.97 5.00
192 INT118388 Localization of Nfe2l2 40 0.81 9.59 5.89 5.00
193 INT111683 Gene_expression of P2ry1 22 0.74 7.96 5.59 5.00
194 INT174851 Positive_regulation of COL5A2 46 0.54 12.73 5.48 5.00
195 INT125066 Negative_regulation of HDAC4 56 0.49 41.55 5.42 5.00
196 INT120511 Positive_regulation of Gene_expression of Cat 26 0.69 19.82 5.2 5.00
197 INT106524 Phosphorylation of Jun 23 0.80 15.35 4.78 5.00
198 INT21582 Regulation of Gene_expression of TIMP1 20 0.61 12.39 4.77 5.00
199 INT102237 Positive_regulation of Gene_expression of MMP3 22 0.44 7.77 4.71 5.00
200 INT137332 Positive_regulation of Gene_expression of Sod1 41 0.70 19.8 4.69 5.00
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