P:Bioavailability

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pChart

Pain Term
Category Other
Synonyms None
Pain Specific No
Documents 2701
Hot Single Events 200
Hot Interactions 80

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported for Bioavailability. They are ordered first by their pain relevance and then by number of times they were reported for Bioavailability. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT220148 Binding of IGF1 and IGFBP3 12 0.36 5.56 0.66 100.00
2 INT129869 SERPINA6 Regulation of AVP 1 0.25 2.33 0.54 100.00
3 INT234626 IGFBP3 Regulation of IGF2 1 0.15 1.31 0.1 100.00
4 INT321919 Binding of DAO and Gopc 1 0.02 0 0.16 100.00
5 INT129868 Regulation of SERPINA6 Regulation of AVP 1 0.25 0.59 0.14 100.00
6 INT234619 IGF1 Regulation of IGF1R 1 0.11 0.39 0.05 100.00
7 INT218614 INS Positive_regulation of Binding of IGF1 1 0.39 0.79 0.05 100.00
8 INT234624 Binding of IGF1 and IGF1R 1 0.09 0.39 0.05 100.00
9 INT234620 Regulation of Binding of IGF1 and IGF1R 1 0.07 0.39 0.05 100.00
10 INT325767 Negative_regulation of Omd Positive_regulation of Ddc 1 0.01 0.38 0.25 99.96
11 INT52459 Binding of SUCLA2 and HEY2 1 0.01 0.09 0.21 99.92
12 INT241167 Binding of TNXA and Serpinc1 1 0.00 0.43 0.13 99.86
13 INT295711 MMP9 Positive_regulation of Localization of VEGFA 1 0.06 0.29 0.74 99.76
14 INT312219 Binding of IGF1 and IGFBP5 1 0.02 0.13 0.08 99.24
15 INT260565 T2dm2 Regulation of SUGT1 1 0.00 1.43 0.05 98.50
16 INT220537 HSPG2 Positive_regulation of NOSTRIN 1 0.04 0 0.05 98.44
17 INT299954 Negative_regulation of LXN Negative_regulation of FTSJ3 1 0.00 0.75 0.05 98.32
18 INT316375 Ang Positive_regulation of Nfkb1 1 0.08 0.73 0.23 98.04
19 INT246576 EEF1A2 Negative_regulation of Negative_regulation of NOSTRIN 1 0.04 0.63 0.24 97.44
20 INT224421 TNFRSF11B Regulation of TNFSF11 1 0.27 0 0.05 97.36
21 INT167583 ENPP2 Positive_regulation of Gene_expression of LPA 1 0.08 0.93 0.51 97.24
22 INT354120 Binding of IGF2 and IGFBP5 1 0.01 0.45 0.09 97.24
23 INT354124 Binding of IGF2 and IGFBP3 1 0.01 0.45 0.09 97.24
24 INT346073 Binding of Alb and Shbg 1 0.00 0 0.09 97.12
25 INT346074 Binding of Alb and Serpina6 1 0.00 0 0.09 97.12
26 INT271350 MPO Positive_regulation of TIMP1 1 0.05 1.66 0.29 96.88
27 INT230750 Crp Positive_regulation of Edn1 1 0.10 0.27 0.09 95.60
28 INT255166 Binding of MOCS1 and MPO 1 0.00 0.7 0.05 95.20
29 INT316370 Ang Positive_regulation of Xdh 1 0.07 0.62 0.2 95.04
30 INT230746 Crp Positive_regulation of Localization of Serpine1 1 0.16 0.27 0.09 94.08
31 INT101676 Sst Negative_regulation of Localization of Gcg 1 0.03 0 0.72 93.96
32 INT312212 Binding of ADAM12 and INPP5K 1 0.16 0.46 0.11 93.92
33 INT331349 Binding of Cl and Mir483 1 0.00 0.23 0.12 93.68
34 INT186954 Binding of Des and Nsdhl 1 0.06 0.32 0.16 93.48
35 INT327814 Rab8a Regulation of Regulation of Lep 1 0.01 0.15 0.19 92.92
36 INT327813 Rab8a Regulation of Lep 1 0.01 0.15 0.19 92.92
37 INT218616 Binding of IGFBP3 and INS 1 0.07 0.68 0.05 92.88
38 INT332689 Binding of Edn1 and Ros1 1 0.08 0.71 0.14 92.56
39 INT69340 Binding of Igh-6 and Ngf 2 0.06 1.04 1.06 92.48
40 INT69343 Binding of NTRK1 and Igh-6 1 0.02 0.69 0.53 92.48
41 INT312226 INPP5K Positive_regulation of IGFBP5 1 0.12 0.07 0.05 92.40
42 INT249962 Binding of KIT and KITLG 6 0.19 3.69 0.17 92.04
43 INT262760 Binding of TEP1 and CD163L1 1 0.00 1.65 0.37 90.64
44 INT295705 Binding of IK and TNF 1 0.00 0.27 0.64 90.44
45 INT321915 Binding of DAO and Ddo 1 0.07 0 0.19 89.92
46 INT321914 Negative_regulation of Binding of Ddo and GRIN3B 1 0.01 0 0.19 89.92
47 INT321918 Binding of Ddo and GRIN3B 1 0.01 0 0.16 89.92
48 INT230748 Agtr2 Positive_regulation of Gene_expression of Ros1 2 0.05 1.04 0.23 89.88
49 INT220146 Binding of IGF1 and IGFBP1 2 0.10 1.57 0.19 89.68
50 INT128756 Binding of Esr1 and Foxc1 1 0.01 0.43 0.32 89.40
51 INT7204 Binding of IFNA1 and IFNG 1 0.01 1.34 0.11 89.20
52 INT291556 Binding of ESR1 and Sec22b 2 0.00 0.86 0.5 89.12
53 INT266445 Binding of HEY1 and GOPC 1 0.00 2.92 0.04 89.04
54 INT266452 Binding of Acot1 and GOPC 1 0.02 1.23 0.04 89.04
55 INT344965 Phc1 Regulation of HP 1 0.02 0.95 0.09 88.60
56 INT178503 Binding of Cd36 and ecs 1 0.01 0.34 0.04 88.00
57 INT250632 Binding of MCPH1 and Fbxo23 1 0.01 0 0.11 87.80
58 INT295721 CSF2 Positive_regulation of MMP9 1 0.06 0.32 0.6 87.60
59 INT295720 PTGER2 Regulation of MMP9 1 0.01 0.53 0.7 87.36
60 INT295724 CXCL12 Positive_regulation of MMP9 1 0.02 0.32 0.6 87.16
61 INT228175 RNU1-1 Regulation of Adipoq 1 0.11 0.78 0.12 86.48
62 INT321893 Binding of DAO and GRIN3B 1 0.03 0 0.19 85.84
63 INT354126 Binding of IGFALS and MIR125A 1 0.23 0.7 0.07 85.60
64 INT354109 Binding of IGFALS and MIR15B 1 0.00 0.7 0.07 85.60
65 INT354116 Binding of IGFALS and MIR524 1 0.02 0.69 0.07 85.60
66 INT282851 Binding of Slc37a4 and Sema6a 1 0.00 0.55 0.21 85.52
67 INT282852 Binding of Slc37a4 and Slc5a8 1 0.01 0.77 0.21 85.36
68 INT354113 Binding of IGFBP3 and MIR524 1 0.01 0.69 0.07 84.72
69 INT354125 Binding of IGFBP3 and MIR15B 1 0.00 0.7 0.07 84.72
70 INT354111 Binding of IGFBP3 and MIR125A 1 0.11 0.7 0.07 84.72
71 INT255690 Binding of VEGFA and Flt1 8 0.34 3.44 0.61 84.56
72 INT16048 MAX Positive_regulation of SLC25A4 1 0.50 0 0.71 84.28
73 INT173053 Binding of VEGFA and NRP2 3 0.12 1.36 0.04 83.44
74 INT315912 VEGFA Regulation of NRP2 1 0.04 0.32 0.04 83.44
75 INT266454 Binding of HEY1 and Acot1 1 0.00 1.19 0.04 82.44
76 INT315915 VEGFA Regulation of NRP1 1 0.22 0.32 0.04 82.08
77 INT173051 Binding of VEGFA and NRP1 16 0.44 1.29 0.04 82.08
78 INT308225 Alb Positive_regulation of Binding of EIF4G2 1 0.02 0.33 0.09 81.00
79 INT230065 Binding of TOR1A and HLA-DOA 1 0.00 1.65 0.09 80.64
80 INT128281 Binding of JUND and NFKB1 1 0.36 0.39 0.13 80.24
81 INT291757 ALDOA Negative_regulation of Positive_regulation of SGCB 1 0.01 0 0.04 79.96
82 INT173059 Binding of KDR and VEGFA 43 0.43 29.63 1.1 79.60
83 INT315913 VEGFA Regulation of KDR 1 0.03 0.32 0.04 79.60
84 INT288616 EPO Positive_regulation of Nos3 1 0.08 0.69 0.11 79.28
85 INT229363 Negative_regulation of Binding of Agt and Agtr1a 2 0.22 0.9 0.32 79.12
86 INT191718 Binding of FLT1 and VEGFA 35 0.50 12.18 0.27 78.64
87 INT315914 VEGFA Regulation of FLT1 1 0.05 0.32 0.04 78.64
88 INT66504 Binding of Agt and Agtr1a 8 0.39 3.78 1.78 78.60
89 INT4638 Binding of Agt and Adarb1 3 0.01 0 0.34 78.60
90 INT308656 Pik3r1 Positive_regulation of Nos3 1 0.02 1.8 0.5 78.24
91 INT308668 Akt1 Positive_regulation of Nos3 3 0.05 4.61 0.65 78.04
92 INT186385 Binding of TNF and Tnfrsf1b 4 0.30 3.24 0.42 77.84
93 INT336925 Aggf1 Positive_regulation of Mir341 1 0.00 0.8 0.21 77.64
94 INT188519 Il1a Positive_regulation of Ptgis 1 0.03 0.08 0.08 77.52
95 INT186393 Binding of TNF and Tnfrsf1a 9 0.37 8.55 1.29 77.12
96 INT285979 Ros1 Positive_regulation of Trib3 2 0.02 2.18 0.2 76.48
97 INT332687 Ros1 Positive_regulation of Crk 1 0.17 0.77 0.12 76.48
98 INT172816 Crp Positive_regulation of Transcription of Nos3 1 0.06 0.91 0.1 76.24
99 INT172819 Crp Positive_regulation of Gene_expression of Nos3 1 0.06 0.91 0.1 76.24
100 INT35398 Fnd3c2 Negative_regulation of Binding of Alox5 1 0.00 0 0.58 75.92
101 INT35400 Fnd3c2 Negative_regulation of Binding of Alox5 and Mthfs 1 0.00 0 0.58 75.92
102 INT35397 Fnd3c2 Negative_regulation of Binding of Mthfs 1 0.00 0 0.58 75.92
103 INT332685 Trib3 Positive_regulation of Binding of Ros1 1 0.01 0.74 0.12 75.80
104 INT230752 Gene_expression of Agtr2 Positive_regulation of Gene_expression of Mcpt1 1 0.01 1.34 0.3 75.72
105 INT200821 Binding of Jak2 and Mvd 1 0.14 0.68 0.04 75.60
106 INT355641 Positive_regulation of MPO Positive_regulation of Gene_expression of ROS1 1 0.24 0.84 0.07 75.44
107 INT241536 Binding of Abcb1b and Abcg2 1 0.10 0.17 0.04 74.56
108 INT35399 Binding of Alox5 and Mthfs 1 0.01 0 1.14 74.28
109 INT300486 LEP Positive_regulation of ROS1 1 0.15 0.91 0.09 74.08
110 INT172817 Crp Positive_regulation of Regulation of Nos3 1 0.09 0.84 0.1 74.00
111 INT172821 Crp Positive_regulation of Negative_regulation of Nos3 1 0.06 0.84 0.1 74.00
112 INT247759 Binding of Ccrl2 and Rarres2 1 0.26 1.19 0.9 73.72
113 INT213239 Binding of TNXA and Serpinc1 1 0.00 0.16 0.08 72.16
114 INT336926 Mir341 Regulation of Tlr4 1 0.02 1.57 0.41 71.12
115 INT213026 Hdl1 Positive_regulation of Nos3 5 0.16 7.92 0.73 70.96
116 INT194977 Binding of Alox5 and Syt1 1 0.04 0.65 0.27 69.12
117 INT252858 C5 Negative_regulation of Positive_regulation of Trpa1 1 0.02 0.78 0.74 68.56
118 INT234625 TP53 Positive_regulation of IGFBP3 1 0.29 0.74 0.03 68.44
119 INT312218 INPP5K Positive_regulation of Protein_catabolism of IGFBP3 1 0.17 0.39 0.11 68.24
120 INT287145 Binding of PNN and Shbg 1 0.07 0.14 0.18 67.48
121 INT332701 Binding of BDKRB1 and BDKRB2 1 0.01 0.5 0.39 67.44
122 INT323278 Dhfr Negative_regulation of Negative_regulation of Igkv1-131 1 0.02 0.93 1.02 66.96
123 INT308670 Positive_regulation of CYBB Positive_regulation of Gene_expression of Ros1 1 0.00 0.68 0.23 66.80
124 INT323280 Dhfr Negative_regulation of Igkv1-131 1 0.02 0.47 0.51 65.72
125 INT344947 IPP Regulation of HP 1 0.03 0.81 0.12 65.60
126 INT202231 Binding of IGF1 and INS 2 0.28 1.38 0.03 65.52
127 INT316546 Binding of GH1 and SST 2 0.03 0.55 0.54 65.40
128 INT354195 Binding of GH1 and Sstr5 1 0.00 0.1 0.17 65.40
129 INT191494 IL6 Positive_regulation of Binding of CRP 1 0.02 1.65 0.65 64.76
130 INT263917 Binding of SST and Sstr5 2 0.02 0.56 0.45 63.76
131 INT272998 IL33 Negative_regulation of CYP2D6 1 0.04 0 0.25 63.32
132 INT138469 Cpb2 Negative_regulation of Gene_expression of Ryr2 1 0.04 0.25 0.32 62.32
133 INT355504 ANGPT2 Positive_regulation of CYBB 1 0.01 0.81 0.18 62.32
134 INT181618 NOS3 Positive_regulation of INS 1 0.02 0.59 0.03 61.92
135 INT354114 Binding of CALR and SST 1 0.01 0.1 0.16 61.56
136 INT355503 Positive_regulation of SCN10A Positive_regulation of Localization of NPY 1 0.17 1.32 0.22 60.84
137 INT300179 Binding of BGLAP and INCENP 1 0.02 0.08 0.03 60.76
138 INT272997 Binding of CYP3A4 and IL33 1 0.03 0 0.25 60.68
139 INT319787 Binding of Dio1 and Ccbp2 1 0.06 0.92 0.03 60.64
140 INT278824 Positive_regulation of Binding of EDNRA and EDNRB 1 0.12 1.65 0.53 60.32
141 INT278819 EDNRA Negative_regulation of Binding of EDNRA and EDNRB 1 0.04 1.65 0.53 60.32
142 INT54972 Binding of EDNRA and EDNRB 7 0.52 3.31 0.97 60.32
143 INT278825 Positive_regulation of Binding of EDN1 and EDNRB 3 0.16 1.24 0.49 60.32
144 INT178097 Binding of EDN1 and EDNRA 7 0.21 5.97 0.62 60.32
145 INT278827 Binding of EDN1 and EDNRB 3 0.17 2.7 0.67 60.32
146 INT278820 EDNRA Negative_regulation of Binding of EDN1 and EDNRB 1 0.03 1.1 0.35 60.32
147 INT278817 EDNRA Negative_regulation of Binding of EDN1 and EDNRA 1 0.02 0.55 0.18 60.32
148 INT278818 EDNRA Negative_regulation of Binding of EDNRB and EDNRB 1 0.06 0.55 0.18 60.32
149 INT278828 Positive_regulation of Binding of EDN1 and EDNRA 1 0.06 0.51 0.15 60.32
150 INT352381 Mir21 Regulation of Ephb1 1 0.02 0 0.03 60.32
151 INT327404 Binding of Xiap and Siva1 1 0.02 1.97 0.03 60.00
152 INT199665 Binding of Fxn and Lamtor3 1 0.00 0.16 0.03 59.68
153 INT320795 Flt1 Negative_regulation of VEGFA 1 0.29 0.29 0.06 59.20
154 INT189671 DAG1 Positive_regulation of PRKCA 3 0.12 0.71 0.82 58.40
155 INT344945 Negative_regulation of ACE Positive_regulation of REN 1 0.23 0.64 0.09 57.72
156 INT143993 Prdx2 Positive_regulation of Atp13a4 1 0.00 0 0.05 56.88
157 INT213023 Hdl1 Regulation of Nos3 2 0.09 4.06 0.09 56.48
158 INT217648 Binding of fa and Hmgcr 1 0.00 0.89 0.03 56.12
159 INT224461 F2RL1 Positive_regulation of CALCRL 1 0.00 0.37 0.31 55.52
160 INT332688 Ros1 Positive_regulation of Binding of Edn1 1 0.10 0.57 0.09 55.28
161 INT271344 MPO Regulation of Protein_catabolism of ACCS 1 0.02 2.42 0.51 53.68
162 INT178502 Col18a1 Negative_regulation of ecs 1 0.01 0.52 0.03 53.32
163 INT277012 Binding of PAPPA and ACE2 1 0.02 1.26 0.15 53.28
164 INT262758 MRGPRF Positive_regulation of Transcription of NFE2L3 1 0.01 1.25 0.09 53.16
165 INT262754 MRGPRF Positive_regulation of NFE2L3 1 0.01 1.24 0.09 53.16
166 INT262755 MRGPRF Positive_regulation of NFE2L2 1 0.18 1.24 0.09 53.16
167 INT251701 Bche Regulation of Gene_expression of Acot1 1 0.03 0.25 0.03 53.04
168 INT292416 SOD1 Regulation of Cat 1 0.01 0.45 0.03 52.76
169 INT199194 Ros1 Negative_regulation of Aldh2 1 0.07 0.27 0.3 51.24
170 INT199190 Ros1 Positive_regulation of Aldh2 1 0.08 0.27 0.3 51.24
171 INT284916 IL1RN Negative_regulation of HDAC4 1 0.00 1.66 0.03 51.12
172 INT344963 Phc1 Regulation of REN 1 0.15 0.66 0.06 51.00
173 INT327406 Lox Positive_regulation of Lox Positive_regulation of Ptk2 1 0.23 2.62 0.19 50.72
174 INT327405 Lox Positive_regulation of Ptk2 1 0.42 1.3 0.1 50.72
175 INT101675 Bcl2l11 Regulation of Localization of Ggh 1 0.03 0 0.72 50.40
176 INT247760 Binding of Cmklr1 and Rarres2 1 0.05 0.75 0.41 50.08
177 INT214817 Siglece Positive_regulation of Gene_expression of TNF 1 0.03 0.49 0 50.00
178 INT71518 Binding of INSRR and Nisch 1 0.00 0.22 0.35 49.84
179 INT199192 Gnat3 Positive_regulation of Hmox1 1 0.27 0.23 0.19 49.04
180 INT199204 Gnat3 Positive_regulation of Gnat3 Positive_regulation of Hmox1 1 0.18 0.15 0.11 49.04
181 INT327806 Binding of ADORA1 and ADORA2A 1 0.06 0.18 0.49 48.32
182 INT176477 Binding of CXCR3 and CXCL10 14 0.25 10.61 5.87 47.00
183 INT287132 Binding of NT5E and Comt 1 0.03 0.11 0.73 46.40
184 INT287130 Positive_regulation of Binding of NT5E and Comt 1 0.04 0 0.12 46.40
185 INT229714 Positive_regulation of Binding of Agt and Ren 1 0.18 0 0 45.96
186 INT316376 Binding of Ang and Atp6ap2 1 0.06 0.87 0.16 45.72
187 INT229713 Binding of Agt and Ren 1 0.14 0 0 45.16
188 INT167582 ENPP2 Regulation of Gene_expression of LPA 1 0.05 0.61 0.26 44.96
189 INT178663 Binding of CXCR3 and TH1L 2 0.04 2.24 1.01 44.88
190 INT200817 Akt1 Positive_regulation of Negative_regulation of Fgr 1 0.25 1.02 0 44.56
191 INT350204 Binding of CAP1 and QPCT 1 0.06 0 0.13 44.00
192 INT200812 Akt1 Positive_regulation of Negative_regulation of Hck 1 0.25 1.02 0 43.84
193 INT354194 Mtpn Negative_regulation of MIR524 1 0.00 0.08 0.11 43.68
194 INT200818 Akt1 Positive_regulation of Negative_regulation of Lyn 1 0.25 1.02 0 43.44
195 INT249597 Jak2 Positive_regulation of Phosphorylation of Stat1 1 0.20 0.13 0.03 42.56
196 INT319786 Ccbp2 Positive_regulation of Negative_regulation of Dio1 1 0.09 0.94 0.05 42.32
197 INT101942 Binding of CD40 and CD40LG 16 0.23 15.24 4.01 42.00
198 INT186957 Nsdhl Positive_regulation of Tmed4 1 0.04 0.71 0.23 41.92
199 INT353010 Binding of GJA8 and TNF 1 0.02 0.24 0.33 41.76
200 INT353009 Binding of GJA8 and VSIG1 1 0.00 0 0.29 41.76

Single Events

The table below shows the top 200 pain related interactions that have been reported for Bioavailability. They are ordered first by their pain relevance and then by number of times they were reported in Bioavailability. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT9660 Regulation of TNF 363 0.62 312.94 139.99 100.00
2 INT16130 Binding of IGF1 67 0.48 27.43 2.95 100.00
3 INT5059 Positive_regulation of TNF 1050 0.70 896.51 322.81 100.00
4 INT48767 Negative_regulation of NOS1 312 0.59 154.25 90.32 100.00
5 INT9682 Positive_regulation of IGF1 238 0.70 120.03 26.36 100.00
6 INT67283 Binding of Serpinc1 8 0.47 5.02 1.01 100.00
7 INT180907 Positive_regulation of COQ10A 21 0.60 3.26 1.88 100.00
8 INT1199 Positive_regulation of INS 579 0.70 399.64 50.43 100.00
9 INT1472 Positive_regulation of Ins1 349 0.69 146.2 86.36 100.00
10 INT50568 Positive_regulation of HCA1 5 0.44 5.56 1.63 100.00
11 INT128563 Binding of Mllt1 8 0.41 6.7 5.63 100.00
12 INT295437 Negative_regulation of Protein_catabolism of CGA 1 0.36 0.05 0.19 100.00
13 INT11729 Regulation of IGF1 71 0.61 44.58 9.71 100.00
14 INT667 Negative_regulation of Hrh2 38 0.58 18.11 18.01 100.00
15 INT248 Positive_regulation of Localization of GH1 137 0.69 49.25 32.92 100.00
16 INT24880 Positive_regulation of HRH2 7 0.69 1.34 2.74 100.00
17 INT186709 Regulation of HCA1 5 0.39 1.91 0.21 100.00
18 INT68708 Negative_regulation of RHCE 4 0.26 2.53 0.48 100.00
19 INT16722 Negative_regulation of MPO 25 0.59 18.55 6.99 100.00
20 INT81945 Negative_regulation of Binding of Esr1 3 0.32 0.55 1.06 100.00
21 INT5759 Positive_regulation of Ptgs1 127 0.69 53.45 53.04 100.00
22 INT215191 Negative_regulation of Gene_expression of Tg(GH)3Mi 1 0.06 0 0.09 100.00
23 INT14560 Regulation of Igf1 41 0.59 19.59 6.3 100.00
24 INT35975 Regulation of Cpox 109 0.39 57.88 49.69 100.00
25 INT8465 Regulation of Ptgs1 100 0.57 36.03 44.41 100.00
26 INT96814 Negative_regulation of APOE 13 0.59 10.64 1.61 100.00
27 INT247730 Regulation of Rarres2 1 0.18 0.37 0.12 100.00
28 INT2543 Positive_regulation of Calca 787 0.70 331.13 592.08 100.00
29 INT610 Regulation of PENK 47 0.62 14.17 31.55 100.00
30 INT109110 Positive_regulation of Pde5a 29 0.63 11.16 16.65 100.00
31 INT35486 Regulation of PTGER2 39 0.36 19.03 6.75 100.00
32 INT25121 Negative_regulation of Positive_regulation of COL7A1 5 0.24 1.32 2.37 100.00
33 INT109327 Negative_regulation of KIT 42 0.57 43.2 2.15 100.00
34 INT223919 Gene_expression of Cdipt 5 0.20 0.89 1.85 100.00
35 INT8667 Localization of HSD11B1 22 0.73 22.74 1.25 100.00
36 INT123877 Negative_regulation of ABL1 40 0.57 27.94 1.17 100.00
37 INT43136 Regulation of Protein_catabolism of CPQ 3 0.31 0.17 1.01 100.00
38 INT34779 Regulation of IGF2 7 0.38 4.34 0.9 100.00
39 INT313673 Negative_regulation of C8A 1 0.04 0.85 0.82 100.00
40 INT164756 Negative_regulation of PDGFRB 32 0.57 21.69 0.72 100.00
41 INT199410 Negative_regulation of Binding of CYP3A4 4 0.43 0.96 0.5 100.00
42 INT176039 Regulation of HMGCR 6 0.17 2.32 0.29 100.00
43 INT173876 Positive_regulation of Positive_regulation of COL7A1 3 0.25 1.57 0.24 100.00
44 INT129422 Negative_regulation of Gmps 2 0.02 1.22 0.19 100.00
45 INT171022 Binding of IGFBP2 1 0.19 0.62 0.16 100.00
46 INT217640 Protein_catabolism of fa 1 0.07 0.92 0.13 100.00
47 INT218022 Negative_regulation of EE 1 0.04 0.07 0.09 100.00
48 INT305385 Negative_regulation of Localization of FLNA 1 0.16 0.79 0.08 100.00
49 INT286067 Regulation of Regulation of Igf1 2 0.37 0.21 0.05 100.00
50 INT16656 Negative_regulation of Gene_expression of YY1 8 0.57 2.62 2.12 99.98
51 INT5235 Negative_regulation of TNF 924 0.59 772.91 331.98 99.96
52 INT69985 Positive_regulation of Negative_regulation of TNF 21 0.50 13.26 6.31 99.96
53 INT108306 Positive_regulation of TNFRSF11B 28 0.60 12.74 4.46 99.96
54 INT9027 Positive_regulation of Ddc 24 0.66 6.04 10.19 99.96
55 INT156606 Positive_regulation of Acd 2 0.42 3.88 0.75 99.96
56 INT156607 Regulation of Acd 1 0.23 0.09 0.61 99.96
57 INT48692 Binding of VEGFA 345 0.48 210.3 21.31 99.92
58 INT28951 Negative_regulation of IGF1 133 0.59 75.77 18.9 99.92
59 INT49983 Negative_regulation of Aap 12 0.58 3.16 7.92 99.92
60 INT232663 Positive_regulation of CCT6A 1 0.13 3.08 5.27 99.92
61 INT291773 Positive_regulation of Positive_regulation of SGCB 1 0.14 0 0.25 99.90
62 INT37863 Regulation of HBG2 11 0.61 3.95 4.34 99.90
63 INT230087 Binding of TOR1A 6 0.35 2.84 0.68 99.88
64 INT241166 Binding of TNXA 1 0.01 0.43 0.13 99.86
65 INT37296 Binding of Esr1 117 0.43 62.51 27.33 99.84
66 INT99003 Regulation of Vcam1 7 0.41 6.91 1.04 99.84
67 INT262344 Negative_regulation of Lgsn 4 0.37 3.6 0.67 99.84
68 INT81443 Positive_regulation of Vcam1 29 0.63 28.4 6.35 99.84
69 INT80981 Regulation of Abcb1a 19 0.62 1.86 7.2 99.82
70 INT9426 Negative_regulation of IGFBP1 5 0.37 1.35 0.51 99.82
71 INT28145 Binding of PAPPA 26 0.48 7.4 4.96 99.80
72 INT114236 Negative_regulation of Sgtb 1 0.23 0.55 0.18 99.80
73 INT224427 Positive_regulation of Binding of TNFRSF11B 1 0.49 0.05 0.08 99.80
74 INT101992 Localization of VEGFA 413 0.81 258.23 36.15 99.76
75 INT250609 Negative_regulation of Negative_regulation of MCPH1 1 0.12 1.03 0.39 99.76
76 INT57785 Positive_regulation of SGCB 25 0.69 5.01 1.49 99.72
77 INT325762 Positive_regulation of Negative_regulation of Omd 1 0.02 0.38 0.25 99.68
78 INT48725 Gene_expression of IGFBP3 128 0.78 78.83 8.19 99.66
79 INT344960 Negative_regulation of LPP 1 0.23 0.83 0.1 99.64
80 INT46646 Localization of FLNA 19 0.73 18.83 2.53 99.64
81 INT268834 Protein_catabolism of KLK5 1 0.15 0.08 0.35 99.60
82 INT76229 Binding of BDKRB1 5 0.33 1.46 3.66 99.60
83 INT8904 Positive_regulation of Gene_expression of EDN1 66 0.70 65.4 14.42 99.58
84 INT6656 Gene_expression of YY1 135 0.75 24.73 72.16 99.54
85 INT149105 Negative_regulation of SOD3 3 0.43 0.74 0.05 99.54
86 INT34777 Localization of IGF1 82 0.80 42.68 8.62 99.52
87 INT215204 Gene_expression of Tg(GH)3Mi 1 0.09 0.36 0.4 99.52
88 INT1179 Negative_regulation of Ace 157 0.59 67.03 30.46 99.52
89 INT125578 Positive_regulation of Localization of IGF1 6 0.60 7.59 0.53 99.52
90 INT215196 Positive_regulation of Gene_expression of Tg(GH)3Mi 1 0.07 0 0.09 99.52
91 INT96917 Positive_regulation of Mapk14 261 0.70 173.29 88.79 99.52
92 INT35366 Binding of AR 87 0.47 30.52 8.9 99.52
93 INT71496 Positive_regulation of Hspb1 15 0.69 14.7 6.86 99.52
94 INT58766 Gene_expression of ANGPT2 41 0.67 21.65 4.82 99.52
95 INT153718 Gene_expression of ANGPT1 15 0.45 10.82 2.13 99.52
96 INT257453 Positive_regulation of USE1 12 0.20 6.7 0.94 99.52
97 INT58764 Negative_regulation of Gene_expression of ANGPT2 7 0.34 2.64 0.69 99.52
98 INT321907 Negative_regulation of DAO 1 0.51 9.08 7.07 99.50
99 INT125377 Localization of CYP2B6 5 0.78 0.59 2.23 99.48
100 INT130750 Negative_regulation of Localization of CYP2B6 1 0.41 0 0.82 99.48
101 INT59466 Gene_expression of ISYNA1 204 0.77 112.57 35.48 99.44
102 INT6726 Positive_regulation of Edn1 118 0.70 65.96 24.07 99.44
103 INT6515 Gene_expression of BGLAP 110 0.75 45.13 10.81 99.44
104 INT67724 Regulation of Gene_expression of ISYNA1 14 0.51 5.99 3.62 99.44
105 INT224480 Binding of F2RL1 5 0.36 5.2 2.19 99.44
106 INT325487 Localization of Ephx2 1 0.71 0.65 0.2 99.44
107 INT22716 Protein_catabolism of ENPEP 5 0.96 0.1 1.49 99.42
108 INT177582 Regulation of Sod1 2 0.24 0.39 0.1 99.42
109 INT546 Binding of ALB 311 0.48 85.98 60.14 99.38
110 INT8905 Gene_expression of EDN1 215 0.78 157.1 34.19 99.38
111 INT73431 Positive_regulation of Nos3 82 0.65 53.22 11.61 99.36
112 INT70134 Negative_regulation of TXK 124 0.23 81.96 9.59 99.36
113 INT73809 Regulation of Nos3 18 0.45 10.05 2.27 99.32
114 INT2276 Regulation of Ins1 234 0.61 103.78 54.05 99.32
115 INT313683 Binding of C8A 1 0.03 0.07 0.26 99.32
116 INT313672 Positive_regulation of Binding of C8A 1 0.04 0 0.09 99.32
117 INT5058 Positive_regulation of IFNA1 356 0.70 245.75 60.52 99.28
118 INT26773 Protein_catabolism of CPQ 8 0.86 0.17 3.49 99.28
119 INT6727 Positive_regulation of Ednra 27 0.64 18.75 8.71 99.26
120 INT158863 Negative_regulation of Ros1 84 0.35 40.3 10.14 99.24
121 INT5905 Negative_regulation of ELANE 113 0.59 47.43 22.09 99.24
122 INT9993 Positive_regulation of Gene_expression of IL2 131 0.69 46.27 30.04 99.24
123 INT77434 Positive_regulation of Gene_expression of Nos2 151 0.69 96.76 38.94 99.24
124 INT56292 Negative_regulation of Gene_expression of Ros1 70 0.38 36.14 9.17 99.24
125 INT307143 Positive_regulation of Berr1 1 0.02 0.51 0.09 99.24
126 INT115202 Positive_regulation of Positive_regulation of Ednra 2 0.39 2.88 0.49 99.22
127 INT45275 Gene_expression of CSH1 39 0.62 9.39 5.85 99.20
128 INT152251 Gene_expression of TMED4 15 0.22 6.15 3.53 99.18
129 INT141864 Negative_regulation of Binding of Nos3 3 0.39 2.27 0.56 99.16
130 INT59464 Regulation of ISYNA1 21 0.43 12.15 4.63 99.16
131 INT316565 Negative_regulation of Regulation of Nos3 1 0.32 1.01 0.22 99.16
132 INT122709 Localization of CYP3A4 16 0.75 5.41 2.38 99.12
133 INT93956 Binding of HBM 20 0.35 8.86 1.48 99.12
134 INT154455 Gene_expression of dds 4 0.58 3.84 0.46 99.12
135 INT83199 Gene_expression of Nos3 193 0.78 100.72 51.57 99.10
136 INT65245 Gene_expression of Nos3 121 0.78 98.14 41.56 99.08
137 INT4403 Binding of CYP2B6 113 0.48 21.17 33.83 99.08
138 INT8683 Positive_regulation of F3 31 0.67 42.89 6.21 99.08
139 INT5116 Gene_expression of IL2 670 0.78 291.13 146.69 99.08
140 INT50580 Binding of PPIG 39 0.36 11.17 12.34 99.08
141 INT167585 Negative_regulation of ENPP2 7 0.36 5.19 2.74 99.06
142 INT2956 Binding of H2-Ab1 19 0.37 3.1 11.18 99.06
143 INT31990 Positive_regulation of SOD1 124 0.69 67.79 12.52 99.04
144 INT64636 Positive_regulation of Gene_expression of Nos2 242 0.70 147.52 79.53 99.04
145 INT50579 Binding of CYP3A4 84 0.48 17.52 17.45 99.02
146 INT6481 Binding of TNF 624 0.48 510.2 214.82 99.00
147 INT212758 Binding of Hmgb1 40 0.44 35.6 7.41 99.00
148 INT79096 Binding of Cyp2e1 12 0.48 4.41 3.8 99.00
149 INT61068 Gene_expression of Igfbp3 15 0.75 8.48 1.41 99.00
150 INT258095 Binding of Igfbp3 4 0.29 2.86 0.23 99.00
151 INT215200 Regulation of Igfbp3 3 0.35 0.71 0.18 99.00
152 INT101494 Regulation of Positive_regulation of Trpv1 18 0.62 6.57 12.9 99.00
153 INT55698 Regulation of Binding of TNF 13 0.44 8.98 4.74 99.00
154 INT258272 Negative_regulation of Binding of Hmgb1 1 0.53 1.82 0.15 99.00
155 INT217636 Regulation of fa 3 0.05 1.2 0.08 99.00
156 INT217641 Positive_regulation of fa 1 0.03 0 0.05 99.00
157 INT217637 Regulation of Positive_regulation of fa 1 0.03 0 0.05 99.00
158 INT217635 Positive_regulation of Regulation of fa 1 0.03 0 0.05 99.00
159 INT2241 Negative_regulation of CEL 56 0.58 29.32 8.83 98.98
160 INT56291 Gene_expression of Ros1 503 0.63 274.12 81.5 98.98
161 INT34720 Positive_regulation of SHBG 58 0.69 32.4 3.83 98.96
162 INT54886 Negative_regulation of ANGPT2 25 0.42 9.33 3.79 98.96
163 INT92415 Positive_regulation of Max 4 0.67 1.13 2.1 98.96
164 INT197662 Negative_regulation of Positive_regulation of SHBG 5 0.39 3.54 0.52 98.96
165 INT259241 Negative_regulation of ED 3 0.37 5.09 0.34 98.96
166 INT252 Localization of GH1 529 0.80 227.4 122.05 98.92
167 INT90675 Negative_regulation of Gene_expression of Nos3 15 0.46 11.11 2.7 98.92
168 INT51530 Negative_regulation of Adk 11 0.56 3.83 9.07 98.92
169 INT199340 Localization of Igf2 4 0.75 4.47 0.39 98.92
170 INT79476 Gene_expression of HLA-DMA 23 0.38 9.5 2.76 98.90
171 INT128983 Protein_catabolism of Comt 5 0.87 0.22 2.6 98.88
172 INT100730 Positive_regulation of Localization of F2RL1 2 0.49 0.99 0.62 98.88
173 INT60779 Negative_regulation of CYP3A 63 0.59 8.38 21.27 98.86
174 INT82839 Negative_regulation of ABCB1 61 0.59 16.09 8.83 98.86
175 INT130748 Negative_regulation of Localization of ABCB1 2 0.42 0.71 1.02 98.86
176 INT130751 Negative_regulation of Localization of CYP3A 1 0.39 0 0.68 98.86
177 INT159058 Negative_regulation of Omd 3 0.37 2.93 1.6 98.84
178 INT54366 Gene_expression of Anpep 6 0.77 1.38 1.52 98.84
179 INT257301 Protein_catabolism of Pde5a 5 0.30 1.97 2.26 98.84
180 INT98476 Gene_expression of Ddr1 3 0.58 1.28 1.6 98.84
181 INT80122 Gene_expression of ESRRB 4 0.41 2.21 0.78 98.84
182 INT6483 Gene_expression of TNF 3152 0.78 2515.62 929.82 98.80
183 INT102515 Binding of Nos3 19 0.45 9.41 4.01 98.80
184 INT70503 Regulation of Gene_expression of Nos2 71 0.62 44 24.01 98.80
185 INT6364 Gene_expression of Edn1 123 0.78 73.76 28.43 98.74
186 INT50405 Negative_regulation of CYP3A4 238 0.59 53.65 51.51 98.72
187 INT660 Negative_regulation of REN 194 0.59 82.06 29.46 98.72
188 INT66280 Gene_expression of Nos2 534 0.78 330.78 157.07 98.72
189 INT83991 Regulation of Nos3 25 0.44 9.89 4.06 98.72
190 INT615 Regulation of Alb 66 0.62 33.43 15.33 98.72
191 INT1934 Positive_regulation of Cys1 68 0.68 60.56 10.47 98.72
192 INT15557 Regulation of Localization of Alb 13 0.50 5.71 2.91 98.72
193 INT114499 Gene_expression of MCPH1 38 0.67 26.68 4.55 98.70
194 INT3657 Gene_expression of Ins1 514 0.78 321.69 75.76 98.68
195 INT307059 Localization of AKTIP 1 0.01 0.48 0.14 98.68
196 INT113160 Negative_regulation of Jak2 26 0.58 20.3 2.57 98.68
197 INT27687 Regulation of Cp 20 0.53 9.75 10.8 98.66
198 INT8629 Positive_regulation of COL7A1 72 0.69 40.66 12.09 98.66
199 INT22211 Positive_regulation of CYP3A4 110 0.70 22 28.27 98.64
200 INT1724 Negative_regulation of ACE 437 0.59 315.64 74.48 98.60
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