P:Botox

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pChart

Pain Term
Category Drug
Synonyms Botulinum Toxin Type A
Pain Specific No
Documents 474
Hot Single Events 82
Hot Interactions 2

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported for Botox. They are ordered first by their pain relevance and then by number of times they were reported for Botox. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT116730 Rac1 Regulation of Localization of Calca 1 0.13 1.32 1.19 100.00
2 INT148930 Rac1 Regulation of Chrna7 1 0.13 0.6 0.44 100.00
3 INT322733 CD40LG Positive_regulation of Gene_expression of CD40 1 0.08 0.62 0.18 40.00
4 INT322734 Binding of CD40LG and Positive_regulation of CD40 1 0.07 0.62 0.18 39.68
5 INT257844 STS Positive_regulation of Negative_regulation of CST7 1 0.01 0.24 0.19 5.00
6 INT171709 Rac1 Negative_regulation of Localization of Chrna7 1 0.04 0.75 0.08 5.00
7 INT192618 Atrx Regulation of Gene_expression of Hba-a1 1 0.08 0.45 0 5.00

Single Events

The table below shows the top 200 pain related interactions that have been reported for Botox. They are ordered first by their pain relevance and then by number of times they were reported in Botox. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT19396 Regulation of Rac1 66 0.53 37.41 30.01 100.00
2 INT23676 Gene_expression of Chrna7 47 0.75 23.66 9.51 100.00
3 INT47459 Gene_expression of Rac1 101 0.68 45.27 24.33 100.00
4 INT23212 Positive_regulation of Rac1 46 0.55 32.85 15.1 100.00
5 INT1221 Regulation of SGCG 65 0.60 24.21 22.94 100.00
6 INT27627 Binding of Rac1 41 0.41 22.88 13.68 100.00
7 INT75682 Regulation of Chrna7 14 0.45 10.24 5.25 100.00
8 INT50055 Negative_regulation of Rac1 36 0.50 19.74 8.98 100.00
9 INT167847 Positive_regulation of Gene_expression of Chrna7 7 0.49 3.02 1.57 100.00
10 INT647 Gene_expression of SGCG 211 0.75 78.46 55.82 100.00
11 INT16013 Gene_expression of Rac1 52 0.75 23.79 1.21 100.00
12 INT70987 Binding of RAC1 14 0.37 12.14 2.13 100.00
13 INT3364 Binding of SGCG 87 0.47 31.93 17.24 100.00
14 INT5050 Regulation of Localization of Calca 149 0.62 41.25 148.57 100.00
15 INT15489 Negative_regulation of Gene_expression of SGCG 10 0.42 4.78 3.18 100.00
16 INT9292 Positive_regulation of SGCG 93 0.67 35.13 23.48 100.00
17 INT58475 Localization of Rac1 12 0.75 5.94 3.2 100.00
18 INT719 Negative_regulation of SGCG 96 0.57 47.91 30.22 100.00
19 INT116729 Regulation of Localization of Rac1 1 0.01 0.07 0.29 100.00
20 INT65928 Positive_regulation of Gene_expression of Rac1 12 0.42 3.34 2.33 100.00
21 INT16012 Binding of Rac1 17 0.37 6.9 0.53 100.00
22 INT15915 Negative_regulation of Positive_regulation of SGCG 3 0.41 0.44 0.28 100.00
23 INT282160 Regulation of Binding of RAC1 1 0.18 0.45 0.13 100.00
24 INT8358 Negative_regulation of Localization of CALCA 25 0.59 11.79 21.51 99.98
25 INT38201 Negative_regulation of Localization of Ache 8 0.59 2.35 1.82 99.98
26 INT116819 Negative_regulation of Localization of TRPV1 3 0.43 1.75 2.71 99.98
27 INT246311 Protein_catabolism of Snap25 6 0.66 1.15 0.89 99.98
28 INT69350 Gene_expression of RAC1 23 0.77 12.16 5.54 99.92
29 INT35269 Localization of SGCG 38 0.78 14.68 9.01 99.90
30 INT4649 Positive_regulation of Chrna7 17 0.50 5.48 3.92 99.88
31 INT626 Localization of CALCA 289 0.81 125.39 221.15 99.74
32 INT9383 Localization of TRPV1 98 0.81 33.23 46.24 99.74
33 INT19071 Localization of Ache 66 0.81 5.1 16.27 99.72
34 INT2542 Localization of Calca 2008 0.81 518.3 1408.65 99.68
35 INT168520 Binding of PDE8B 1 0.30 0.78 0.22 99.52
36 INT4758 Positive_regulation of Localization of Calca 557 0.70 138.55 411.04 99.46
37 INT175652 Positive_regulation of BPHL 9 0.44 17.98 1.14 99.24
38 INT22909 Positive_regulation of Chdh 26 0.68 28.69 16.13 99.10
39 INT63164 Negative_regulation of Cst7 51 0.50 18.48 20.3 98.92
40 INT66646 Regulation of Chdh 13 0.44 16.24 8.84 98.84
41 INT92966 Positive_regulation of FGF1 4 0.38 2.25 1.33 98.32
42 INT236872 Regulation of BPHL 6 0.16 6.52 1.14 98.26
43 INT5200 Gene_expression of Fos 3083 0.78 894.43 1639.02 97.64
44 INT6056 Negative_regulation of Gene_expression of Fos 601 0.59 193.05 386.84 97.64
45 INT5590 Negative_regulation of Fos 144 0.59 40.94 81.98 97.64
46 INT2649 Regulation of Calca 433 0.62 146.05 330.95 97.48
47 INT23330 Binding of Chrna7 79 0.48 10.06 35.5 97.44
48 INT7898 Gene_expression of Homer1 123 0.78 31.52 53.67 97.36
49 INT169387 Regulation of Gene_expression of Chrna7 4 0.36 2.19 1.63 97.24
50 INT9798 Negative_regulation of Gene_expression of Homer1 10 0.41 2.04 3.77 96.36
51 INT115303 Localization of SNAP25 8 0.73 1.43 1.82 96.30
52 INT196247 Negative_regulation of Localization of SNAP25 2 0.29 0.76 0.37 96.30
53 INT175904 Localization of RAC1 7 0.41 5.05 0.86 96.24
54 INT115596 Regulation of Regulation of Rac1 1 0.36 0.29 0.7 95.76
55 INT539 Negative_regulation of Chrna7 14 0.42 4.59 6.42 95.56
56 INT7056 Positive_regulation of Gene_expression of PENK 35 0.70 14.31 18.21 94.24
57 INT24149 Gene_expression of BPHL 58 0.59 93.54 2.91 94.16
58 INT2289 Gene_expression of PENK 203 0.78 55.62 79.49 93.64
59 INT1273 Gene_expression of Avp 356 0.78 90.56 138.7 93.48
60 INT8357 Gene_expression of KNG1 153 0.75 77.26 68.66 93.28
61 INT5116 Gene_expression of IL2 670 0.78 291.13 146.69 93.28
62 INT172411 Regulation of SV2A 3 0.22 0.93 0.61 93.08
63 INT78619 Positive_regulation of RAC1 27 0.65 10.43 3.75 92.08
64 INT3167 Binding of KNG1 48 0.48 23.26 26.77 91.60
65 INT47425 Localization of Chrna7 11 0.81 6.7 1.86 91.52
66 INT4759 Negative_regulation of Localization of Calca 294 0.59 82.62 226.45 91.52
67 INT144689 Regulation of RCT 49 0.53 25.91 9.6 90.72
68 INT98445 Negative_regulation of BPHL 7 0.32 7.24 1.08 89.76
69 INT85885 Positive_regulation of SNAP25 8 0.69 2.74 2.84 88.08
70 INT334551 Regulation of HAS1 1 0.04 0.46 0.04 87.88
71 INT334554 Positive_regulation of HAS1 1 0.07 0.46 0.04 87.88
72 INT115304 Regulation of SNAP25 7 0.60 1.24 0.95 87.80
73 INT190390 Binding of Napb 6 0.22 2.07 2.01 86.76
74 INT2540 Negative_regulation of Calca 538 0.59 172.11 384.38 86.68
75 INT191343 Gene_expression of IDO1 23 0.55 11.3 4.81 86.68
76 INT334553 Localization of HAS1 1 0.11 1.07 0.09 86.48
77 INT211361 Regulation of RENBP 5 0.08 2.8 0.38 85.08
78 INT103251 Negative_regulation of Localization of Calca 13 0.43 9.36 8.86 83.84
79 INT5008 Localization of Calca 204 0.81 80.35 125.16 83.24
80 INT7134 Localization of KNG1 127 0.79 65.73 67.97 83.24
81 INT8786 Negative_regulation of ALDH7A1 27 0.52 12.81 4.76 81.52
82 INT149259 Gene_expression of RCT 38 0.67 15.73 3.87 81.04
83 INT334903 Positive_regulation of Localization of Chrna7 2 0.04 0.83 0.23 79.52
84 INT200373 Binding of Omd 7 0.34 7.03 0.34 77.20
85 INT121967 Regulation of RAC1 9 0.45 6.14 3.41 75.28
86 INT58930 Negative_regulation of RAC1 14 0.55 7.55 1.4 75.00
87 INT64777 Negative_regulation of COL5A2 32 0.38 17.4 2.28 74.92
88 INT158123 Negative_regulation of Gene_expression of COL5A2 19 0.46 15.27 2.23 74.92
89 INT158124 Gene_expression of COL5A2 136 0.69 72.3 12.44 74.40
90 INT200372 Positive_regulation of Omd 3 0.33 2.23 0.57 73.92
91 INT168262 Positive_regulation of Gene_expression of BPHL 10 0.24 10.72 0.83 68.56
92 INT27170 Gene_expression of Maoa 13 0.67 3.88 7.5 65.68
93 INT98061 Negative_regulation of Binding of Rac1 3 0.43 2.28 1.13 63.12
94 INT88464 Negative_regulation of CST7 11 0.31 5.33 2.17 62.28
95 INT22272 Negative_regulation of HTR2A 28 0.57 7.62 13.87 55.84
96 INT127736 Regulation of Gene_expression of RAC1 2 0.27 2 0.53 54.76
97 INT20721 Localization of ACOT1 47 0.80 11.37 10.95 50.40
98 INT1912 Gene_expression of Calca 1152 0.78 453.25 739.84 50.00
99 INT2543 Positive_regulation of Calca 787 0.70 331.13 592.08 50.00
100 INT8700 Positive_regulation of Positive_regulation of Calca 56 0.67 21.69 53.66 50.00
101 INT11406 Positive_regulation of Localization of CALCA 49 0.70 20.64 42.8 50.00
102 INT36428 Binding of Chdh 42 0.47 48.04 26.54 50.00
103 INT20722 Regulation of Localization of ACOT1 5 0.27 1.43 2.86 50.00
104 INT20720 Negative_regulation of Localization of ACOT1 6 0.35 2.66 2.25 50.00
105 INT116848 Negative_regulation of Chdh 10 0.42 19.68 1.95 50.00
106 INT67174 Negative_regulation of Rac1 22 0.56 10.72 0.99 50.00
107 INT194981 Regulation of IMPACT 5 0.38 1.47 0.63 50.00
108 INT148186 Negative_regulation of Znhit6 2 0.15 0.12 0 50.00
109 INT1724 Negative_regulation of ACE 437 0.59 315.64 74.48 49.88
110 INT5940 Negative_regulation of Avp 236 0.59 67.86 101.2 42.88
111 INT22237 Localization of NTS 14 0.75 5.5 2.77 42.08
112 INT329191 Negative_regulation of Localization of NTS 1 0.08 0.48 0.2 42.08
113 INT13286 Gene_expression of Ca2 317 0.67 71.58 65.01 40.40
114 INT12029 Gene_expression of Car1 143 0.67 29.69 36.39 40.20
115 INT80755 Gene_expression of CD40 88 0.75 53.68 17.86 40.00
116 INT10019 Binding of CD8A 57 0.36 31.49 10.08 36.84
117 INT24816 Binding of CD40LG 68 0.47 45.48 11.56 36.16
118 INT264629 Localization of Rac1 8 0.72 5.7 0.79 35.12
119 INT183560 Binding of GABRB3 12 0.23 2.59 3.77 34.36
120 INT1033 Positive_regulation of Ca2 507 0.68 131.76 147.64 33.84
121 INT264637 Localization of CLDN4 3 0.73 0.85 0.29 31.84
122 INT257849 Binding of CST7 2 0.18 0 0.44 28.04
123 INT190396 Positive_regulation of Gene_expression of Scn8a 2 0.45 0.77 0.86 25.92
124 INT5430 Gene_expression of Scn8a 37 0.75 4.58 14.82 25.68
125 INT61904 Gene_expression of CST7 3 0.53 3.22 2.53 22.40
126 INT13085 Positive_regulation of ACE 50 0.70 44.2 8.31 16.04
127 INT109559 Localization of Napa 16 0.61 1.3 2.42 14.08
128 INT257362 Negative_regulation of Localization of RAC1 1 0.24 0.58 0 6.96
129 INT122051 Negative_regulation of ROM1 17 0.48 9.11 3.38 5.64
130 INT6483 Gene_expression of TNF 3152 0.78 2515.62 929.82 5.00
131 INT76660 Gene_expression of Trpv1 691 0.78 329.46 386.42 5.00
132 INT18357 Gene_expression of TRPV1 825 0.78 307.11 382.81 5.00
133 INT9381 Positive_regulation of TRPV1 523 0.70 187.4 276.05 5.00
134 INT87687 Positive_regulation of Trpv1 409 0.70 210.24 257.59 5.00
135 INT170025 Gene_expression of Fig4 588 0.67 183.27 113.32 5.00
136 INT65731 Gene_expression of Cnr1 234 0.78 63.82 109.34 5.00
137 INT77435 Positive_regulation of Nos2 343 0.70 208.49 91.43 5.00
138 INT2520 Negative_regulation of Ca2 271 0.57 72.13 83.71 5.00
139 INT25363 Negative_regulation of Trpv1 144 0.59 64.78 75.7 5.00
140 INT15769 Gene_expression of Il1b 146 0.78 114.51 75.35 5.00
141 INT98621 Regulation of Trpv1 121 0.62 79.24 75.23 5.00
142 INT65733 Positive_regulation of Cnr1 125 0.70 40.27 67.33 5.00
143 INT65730 Gene_expression of Cnr2 129 0.78 60.15 63.1 5.00
144 INT20375 Gene_expression of Hand1 213 0.60 148.51 54.53 5.00
145 INT5759 Positive_regulation of Ptgs1 127 0.69 53.45 53.04 5.00
146 INT1456 Regulation of Oprl1 61 0.62 19.5 52.87 5.00
147 INT50334 Negative_regulation of Cnr1 84 0.58 30.86 51.75 5.00
148 INT20382 Gene_expression of Hand2 211 0.66 142.26 51.05 5.00
149 INT170646 Negative_regulation of Fig4 213 0.37 81.29 46.92 5.00
150 INT63383 Binding of Cnr1 77 0.48 22.28 44.61 5.00
151 INT98498 Binding of Trpv1 75 0.48 33.67 44.4 5.00
152 INT66005 Regulation of Cnr1 47 0.61 19.21 34.52 5.00
153 INT34465 Regulation of Oprd1 34 0.45 7.14 34.29 5.00
154 INT125190 Regulation of Gene_expression of Trpv1 38 0.62 32.57 23.2 5.00
155 INT105021 Binding of GOPC 187 0.40 60.39 20.38 5.00
156 INT101578 Regulation of Cnr2 26 0.62 16.7 19.12 5.00
157 INT120446 Positive_regulation of Cnr2 32 0.70 16.3 18.91 5.00
158 INT66004 Binding of Cnr2 35 0.48 12.82 18.63 5.00
159 INT3060 Negative_regulation of Bche 94 0.59 46.75 18.51 5.00
160 INT94467 Positive_regulation of Hand1 71 0.58 59 16.96 5.00
161 INT92354 Localization of ESR1 77 0.75 33.04 15.51 5.00
162 INT111488 Gene_expression of HAS1 56 0.77 32.6 15.29 5.00
163 INT127022 Gene_expression of Lts1 43 0.23 28.29 12.64 5.00
164 INT11141 Negative_regulation of Gene_expression of Avp 23 0.59 3.85 12.19 5.00
165 INT48335 Negative_regulation of NOSTRIN 38 0.56 16.22 12.05 5.00
166 INT94465 Positive_regulation of Gene_expression of Hand1 43 0.38 29.76 10.88 5.00
167 INT73234 Positive_regulation of Lbp 13 0.69 12.55 8.57 5.00
168 INT5409 Negative_regulation of G6pd 33 0.57 29.21 7.64 5.00
169 INT171146 Negative_regulation of Gene_expression of Fig4 38 0.37 11.41 7.42 5.00
170 INT93046 Positive_regulation of Gene_expression of Hand2 27 0.47 24.54 7.01 5.00
171 INT168399 Localization of Cnr2 12 0.81 4.37 6.77 5.00
172 INT2513 Binding of Napa 80 0.42 4.29 6.51 5.00
173 INT134585 Negative_regulation of Cnr2 10 0.43 3.98 6.16 5.00
174 INT33612 Binding of NTS 16 0.46 4.65 6 5.00
175 INT25123 Negative_regulation of COL7A1 42 0.58 19.98 5.96 5.00
176 INT45275 Gene_expression of CSH1 39 0.62 9.39 5.85 5.00
177 INT120335 Gene_expression of SNAP25 24 0.65 9.44 5.83 5.00
178 INT760 Negative_regulation of Scn8a 11 0.42 1.65 5.6 5.00
179 INT106189 Regulation of Il12a 18 0.44 12.4 5.3 5.00
180 INT189842 Negative_regulation of Gene_expression of Cnr2 8 0.59 4.21 4.67 5.00
181 INT46350 Gene_expression of Msr1 32 0.65 29.39 4.55 5.00
182 INT30031 Gene_expression of Hba-a1 7 0.60 7.46 4.41 5.00
183 INT173910 Gene_expression of LRP2 24 0.75 19.99 4.09 5.00
184 INT11107 Binding of Lbp 12 0.42 4.42 3.41 5.00
185 INT57222 Gene_expression of ATF3 22 0.78 54.71 3.28 5.00
186 INT111099 Positive_regulation of Dusp1 11 0.68 7.62 3.18 5.00
187 INT76430 Gene_expression of SLC1A1 2 0.03 0.77 3.15 5.00
188 INT37590 Regulation of COL7A1 15 0.54 9.4 3.12 5.00
189 INT6895 Localization of Mastl 5 0.31 2.94 2.96 5.00
190 INT114295 Gene_expression of Gli2 10 0.54 7.58 2.95 5.00
191 INT177459 Negative_regulation of RCT 13 0.25 7.9 2.7 5.00
192 INT203154 Positive_regulation of Gene_expression of Lts1 6 0.17 3.68 2.67 5.00
193 INT1643 Regulation of CSH1 10 0.26 2.45 2.53 5.00
194 INT345985 Positive_regulation of Gene_expression of SLC1A1 1 0.01 0.35 2.2 5.00
195 INT174541 Positive_regulation of Gene_expression of COL5A2 18 0.36 14.17 2.12 5.00
196 INT126374 Gene_expression of Gli3 6 0.77 3.67 2.02 5.00
197 INT258780 Regulation of Il23a 6 0.13 4.77 1.96 5.00
198 INT117980 Regulation of Rac1 10 0.45 3.72 1.88 5.00
199 INT258781 Regulation of Regulation of Il12a 1 0.17 1.54 1.87 5.00
200 INT47885 Gene_expression of Max 5 0.65 0.54 1.84 5.00
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