P:Breakthrough pain

From wiki-pain
Jump to: navigation, search

pChart

Pain Term
Category Pain type
Synonyms None
Pain Specific Yes
Documents 425
Hot Single Events 16
Hot Interactions 1

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported for Breakthrough pain. They are ordered first by their pain relevance and then by number of times they were reported for Breakthrough pain. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT117504 OPA1 Positive_regulation of CPP 1 0.09 1.09 1.13 93.52
2 INT299311 Binding of RPTOR and RICTOR 1 0.38 0.21 1.4 54.04
3 INT299281 Binding of RPTOR and MAPKAP1 1 0.23 0.21 1.3 54.04
4 INT299288 AKT1 Positive_regulation of RPTOR 1 0.34 0.05 0.36 41.68
5 INT299307 AKT1 Positive_regulation of Positive_regulation of AKT1S1 1 0.10 0 0.3 41.68
6 INT299289 AKT1 Positive_regulation of Positive_regulation of TSC2 1 0.17 0 0.3 41.68
7 INT299282 PTPN3 Negative_regulation of Positive_regulation of RPTOR 1 0.07 0.48 0.67 24.00
8 INT299285 SRC Regulation of Gene_expression of QPCT 1 0.03 0 0 20.36
9 INT299286 VEGFA Positive_regulation of PI3 1 0.16 0.46 0.6 20.00
10 INT299299 VEGFA Positive_regulation of SRC 1 0.20 0.91 1.2 19.68
11 INT299263 PTPN3 Negative_regulation of VEGFA Positive_regulation of SRC 1 0.03 0.35 0.57 18.24
12 INT299303 SRC Regulation of Phosphorylation of VEGFA 1 0.12 0.05 0 14.20
13 INT299296 SRC Regulation of RPTOR 1 0.32 0 0 14.20
14 INT299308 SRC Regulation of PI3 1 0.20 0 0 14.20
15 INT299294 SRC Regulation of VEGFA 1 0.20 0 0 14.20
16 INT77646 Binding of Ngf and Ntrk1 23 0.40 7.85 9.26 5.00
17 INT88279 Ngf Positive_regulation of Ntrk1 5 0.76 3.06 5.23 5.00
18 INT351380 Ngf Regulation of TPM1 1 0.44 2.17 2.11 5.00
19 INT351246 Binding of OPN1LW and NNT 1 0.03 0.53 1.45 5.00
20 INT351245 Binding of TNC and OPN1LW 1 0.03 0.89 1.31 5.00
21 INT351379 Ngf Positive_regulation of Binding of Ngf and Ntrk1 1 0.38 0.63 1.21 5.00
22 INT351373 Ngf Positive_regulation of Gene_expression of Ntrk1 1 0.35 0.41 1.18 5.00
23 INT351378 Gene_expression of Ngf Positive_regulation of Ntrk1 1 0.35 0.41 1.18 5.00
24 INT351377 Gene_expression of Ngf Positive_regulation of Gene_expression of Ntrk1 1 0.35 0.41 1.18 5.00
25 INT351374 Mir470 Negative_regulation of Ntrk3 1 0.00 1.55 0.7 5.00
26 INT351375 Mir470 Negative_regulation of Ntrk2 1 0.01 1.54 0.7 5.00
27 INT351376 Mir470 Negative_regulation of Ntrk1 1 0.01 1.54 0.7 5.00
28 INT299310 RPTOR Positive_regulation of AKT1 1 0.30 0 0.12 5.00
29 INT341294 DRG1 Positive_regulation of Atf3 1 0.01 0 0.1 5.00
30 INT299291 Negative_regulation of PTPN3 Positive_regulation of Phosphorylation of SRC 1 0.07 0.12 0.07 5.00
31 INT299264 PTPN3 Negative_regulation of VEGFA Positive_regulation of PI3 1 0.03 0.12 0.05 5.00
32 INT299302 Negative_regulation of RPTOR Regulation of AKT1 1 0.30 0.1 0.05 5.00
33 INT299304 RPTOR Regulation of AKT1 1 0.19 0.1 0.05 5.00
34 INT299312 VEGFA Positive_regulation of QPCT 1 0.02 0 0 5.00
35 INT299305 VEGFA Positive_regulation of Positive_regulation of SRC 1 0.22 0 0 5.00
36 INT299300 SRC Positive_regulation of Phosphorylation of AKT1 1 0.24 0 0 5.00
37 INT299309 VEGFA Positive_regulation of Positive_regulation of PI3 1 0.18 0 0 5.00
38 INT299292 RPTOR Negative_regulation of PI3 1 0.25 0 0 5.00
39 INT299306 Binding of QPCT and RICTOR 1 0.02 0 0 5.00
40 INT299295 OR3A4P Negative_regulation of Phosphorylation of AKT1 1 0.00 0.22 0 5.00
41 INT299284 RICTOR Negative_regulation of PI3 1 0.18 0 0 5.00
42 INT331909 Binding of ALB and SPARC 1 0.06 2.01 0 5.00
43 INT299280 VEGFA Positive_regulation of RPTOR 1 0.29 0 0 5.00
44 INT299298 SRC Negative_regulation of PI3 1 0.19 0 0 5.00
45 INT299279 AKT1 Negative_regulation of PI3 1 0.08 0 0 5.00
46 INT299283 Binding of VEGFA and RPTOR 1 0.19 0 0 5.00
47 INT299301 VEGFA Positive_regulation of Positive_regulation of QPCT 1 0.02 0 0 5.00
48 INT299287 Binding of VEGFA and QPCT 1 0.02 0 0 5.00
49 INT299290 Binding of VEGFA and RICTOR 1 0.16 0 0 5.00
50 INT299293 Binding of QPCT and RPTOR 1 0.02 0 0 5.00

Single Events

The table below shows the top 200 pain related interactions that have been reported for Breakthrough pain. They are ordered first by their pain relevance and then by number of times they were reported in Breakthrough pain. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT153140 Transcription of Impact 1 0.60 0.51 0.51 99.62
2 INT27242 Gene_expression of PGR 153 0.75 98.77 12.79 99.00
3 INT22205 Gene_expression of CCT6A 7 0.29 0.86 6.63 98.88
4 INT341682 Positive_regulation of C5orf38 1 0.28 0.3 1.53 98.50
5 INT232663 Positive_regulation of CCT6A 1 0.13 3.08 5.27 96.92
6 INT7134 Localization of KNG1 127 0.79 65.73 67.97 96.84
7 INT97175 Binding of SUGP1 1 0.47 3.5 5.38 96.52
8 INT50972 Negative_regulation of Ntrk1 39 0.51 32.22 17.29 96.16
9 INT23784 Gene_expression of FAIM3 25 0.55 2.89 17.14 93.92
10 INT7057 Binding of FAIM3 19 0.48 4.02 13.78 93.92
11 INT275875 Negative_regulation of Localization of Aes 2 0.19 3.87 1.8 86.24
12 INT351212 Negative_regulation of Commd3 1 0.17 1.29 1.18 86.04
13 INT351211 Regulation of Commd3 1 0.18 3.06 1.56 85.12
14 INT158070 Localization of Aes 23 0.65 19.93 10.9 84.44
15 INT163162 Gene_expression of Crot 2 0.57 1.13 1.82 83.96
16 INT52464 Negative_regulation of Bdkrb1 9 0.57 8.71 5.87 83.00
17 INT10344 Localization of Jun 23 0.73 6.36 7.46 78.72
18 INT99688 Negative_regulation of Gene_expression of VEGFA 274 0.58 201.8 31.1 74.44
19 INT68684 Gene_expression of VEGFA 2371 0.78 1742.52 259.2 73.88
20 INT5200 Gene_expression of Fos 3083 0.78 894.43 1639.02 73.68
21 INT170025 Gene_expression of Fig4 588 0.67 183.27 113.32 73.52
22 INT82611 Negative_regulation of SRC 30 0.57 20.16 5.47 72.68
23 INT131408 Positive_regulation of Negative_regulation of Bdkrb1 1 0.49 1.7 1.32 71.56
24 INT269719 Positive_regulation of Localization of FAIM3 1 0.17 0.22 2.36 70.20
25 INT269718 Localization of FAIM3 1 0.25 0.22 2.35 69.88
26 INT68682 Positive_regulation of VEGFA 640 0.70 454.14 81.65 65.96
27 INT86187 Positive_regulation of AKT1 199 0.69 122.13 19.44 65.44
28 INT52180 Binding of Aes 38 0.42 23.16 6.7 65.36
29 INT264641 Binding of AES 25 0.42 18.56 6.98 63.68
30 INT230251 Binding of FKBP1A 6 0.28 2.24 0.94 58.20
31 INT299316 Binding of FIBP 2 0.01 1.36 0.78 58.20
32 INT69992 Negative_regulation of Hmox2 93 0.50 49.01 44.07 56.72
33 INT299340 Negative_regulation of RPTOR 1 0.53 1.68 2.6 56.20
34 INT107575 Positive_regulation of Gene_expression of Atf3 25 0.69 27.37 14.55 54.88
35 INT107576 Gene_expression of Atf3 114 0.78 72.42 38.64 54.20
36 INT51922 Localization of Cpox 24 0.68 12.05 8.59 52.32
37 INT299350 Phosphorylation of RPTOR 1 0.75 0.26 0.82 51.00
38 INT89396 Phosphorylation of AKT1 225 0.82 111.66 19.61 50.12
39 INT50405 Negative_regulation of CYP3A4 238 0.59 53.65 51.51 50.00
40 INT85843 Negative_regulation of BPI 5 0.35 5.13 3.77 50.00
41 INT216858 Negative_regulation of PID1 4 0.35 6.3 1.11 50.00
42 INT69484 Positive_regulation of Gene_expression of OPRM1 75 0.70 12.86 52.27 49.48
43 INT11624 Gene_expression of OPRM1 445 0.78 72.36 294.36 48.20
44 INT109450 Positive_regulation of Phosphorylation of AKT1 62 0.64 25.18 4.21 46.76
45 INT102722 Phosphorylation of PDPK1 3 0.82 1.39 0.4 45.72
46 INT12384 Positive_regulation of PI3 7 0.38 5.73 2.33 45.00
47 INT70526 Binding of CALR 11 0.35 7.09 1.97 44.96
48 INT238439 Positive_regulation of PDPK1 2 0.20 1.3 0.31 44.56
49 INT615 Regulation of Alb 66 0.62 33.43 15.33 43.12
50 INT179380 Regulation of ABCB7 1 0.26 0.27 1.04 43.12
51 INT4941 Positive_regulation of Oprd1 345 0.70 74.26 304.41 42.84
52 INT14831 Negative_regulation of TNC 18 0.50 8.71 4.61 42.16
53 INT50058 Negative_regulation of Cpox 907 0.58 426.28 428.29 41.32
54 INT221833 Positive_regulation of TSC2 2 0.23 0.39 0.33 39.88
55 INT299320 Positive_regulation of AKT1S1 1 0.13 0 0.29 39.88
56 INT252054 Phosphorylation of TSC2 4 0.80 0.63 0.67 39.32
57 INT299337 Phosphorylation of AKT1S1 1 0.17 0 0.29 39.32
58 INT80124 Negative_regulation of VEGFA 450 0.58 311.19 44.53 38.16
59 INT299331 Positive_regulation of RPTOR 1 0.63 0.9 1.62 37.56
60 INT50971 Gene_expression of Ntrk1 180 0.75 73.52 62.28 37.44
61 INT50973 Negative_regulation of Gene_expression of Ntrk1 22 0.56 11.12 7.38 37.44
62 INT263820 Phosphorylation of RPS6KB1 6 0.52 1.43 0.42 36.56
63 INT246186 Phosphorylation of EIF4EBP1 5 0.46 0.42 0.27 36.56
64 INT351371 Negative_regulation of Mir470 1 0.01 0.34 0.25 35.80
65 INT11721 Localization of Srms 3 0.61 0.76 1.24 34.32
66 INT207735 Negative_regulation of TPM1 3 0.57 2.77 0.83 33.28
67 INT341683 Binding of C5orf38 1 0.21 0.09 1.22 31.20
68 INT299342 Regulation of RPTOR 1 0.41 1.06 1.1 30.48
69 INT105336 Regulation of AKT1 52 0.56 32.53 4.89 30.00
70 INT89392 Negative_regulation of Positive_regulation of AKT1 23 0.50 15.69 3.02 30.00
71 INT118792 Regulation of Positive_regulation of AKT1 8 0.61 3.73 1.15 30.00
72 INT299338 Negative_regulation of Regulation of AKT1 2 0.31 2.32 0.68 30.00
73 INT107103 Negative_regulation of Ntrk2 21 0.59 10.38 5.28 29.16
74 INT122881 Negative_regulation of Ntrk3 10 0.51 5.52 2.04 29.16
75 INT10798 Positive_regulation of CYP2D6 24 0.56 5.82 11.31 26.64
76 INT184932 Binding of Sry 1 0.31 2.57 2.28 25.92
77 INT57721 Localization of CCT6A 2 0.16 3.12 5.88 25.16
78 INT163163 Positive_regulation of Crot 1 0.42 0.66 1.21 25.00
79 INT9551 Regulation of AK1 2 0.03 1.38 1.03 24.40
80 INT232664 Regulation of Positive_regulation of AK1 1 0.02 0.91 0.95 24.40
81 INT46369 Positive_regulation of AK1 3 0.09 1.24 0.94 24.40
82 INT97245 Gene_expression of AKT1 217 0.77 119.63 15.59 24.00
83 INT101866 Positive_regulation of Gene_expression of AKT1 49 0.52 17.47 2.14 24.00
84 INT341291 Positive_regulation of Negative_regulation of Tnfrsf11b 1 0.09 1.34 0.45 22.12
85 INT341289 Positive_regulation of Localization of Tnfsf11 1 0.13 1.26 0.44 22.12
86 INT341290 Localization of Tnfrsf11b 1 0.14 1.28 0.45 21.24
87 INT340265 Localization of Tnfsf11 2 0.30 1.65 0.44 21.24
88 INT32692 Positive_regulation of Aif1 33 0.35 13.29 9.03 20.88
89 INT232666 Negative_regulation of AK1 1 0.02 2.52 1.88 20.80
90 INT100688 Gene_expression of SRC 28 0.75 15.51 3.08 20.56
91 INT263023 Gene_expression of PI3 6 0.75 2.68 1.39 20.56
92 INT219950 Negative_regulation of Gene_expression of SRC 2 0.29 1.32 1.15 20.56
93 INT299325 Negative_regulation of Gene_expression of PI3 1 0.24 0.35 0.63 20.56
94 INT139474 Negative_regulation of Tnfrsf11b 9 0.34 5.74 1.05 20.12
95 INT69727 Gene_expression of QPCT 18 0.65 5.45 3.05 17.96
96 INT184933 Positive_regulation of Binding of Sry 1 0.42 1.23 1.42 16.80
97 INT53290 Gene_expression of OPN1LW 5 0.31 6.9 9.15 15.00
98 INT93490 Gene_expression of GPM6A 14 0.69 3.14 9.08 14.92
99 INT232661 Negative_regulation of Gene_expression of GPM6A 1 0.02 0.81 1.2 14.92
100 INT245598 Positive_regulation of PTPN3 3 0.34 1.13 1.23 14.08
101 INT111545 Phosphorylation of VEGFA 50 0.76 22.19 5.88 13.64
102 INT299353 Phosphorylation of PI3 1 0.35 0.1 0 13.08
103 INT4658 Binding of OPRM1 188 0.48 25.96 136.24 11.20
104 INT149349 Regulation of Atf3 8 0.45 10 3.85 10.60
105 INT299359 Positive_regulation of Binding of QPCT 1 0.04 0.05 0 10.24
106 INT246524 Binding of QPCT 4 0.05 3.65 0.72 9.68
107 INT113439 Positive_regulation of OPN1LW 2 0.11 0.84 2.01 7.48
108 INT129017 Negative_regulation of Phosphorylation of Ntrk1 3 0.41 1.5 1.42 6.68
109 INT129020 Phosphorylation of Ntrk1 17 0.80 5.97 6.37 6.12
110 INT2542 Localization of Calca 2008 0.81 518.3 1408.65 5.00
111 INT158 Localization of Prl 2431 0.81 378.96 952.2 5.00
112 INT7114 Positive_regulation of Ltp 1192 0.62 290.76 755.77 5.00
113 INT5202 Positive_regulation of Gene_expression of Fos 1163 0.70 319.28 684 5.00
114 INT5228 Positive_regulation of Fos 934 0.70 209.8 503.87 5.00
115 INT5660 Binding of Oprd1 477 0.48 71.86 342.06 5.00
116 INT5979 Gene_expression of Oprd1 428 0.78 75.64 320.32 5.00
117 INT34869 Negative_regulation of PTGS2 778 0.59 366.76 319.85 5.00
118 INT4759 Negative_regulation of Localization of Calca 294 0.59 82.62 226.45 5.00
119 INT626 Localization of CALCA 289 0.81 125.39 221.15 5.00
120 INT2391 Negative_regulation of PTGS1 501 0.59 207.62 205.6 5.00
121 INT6354 Localization of Gabrg1 321 0.74 41.41 186.74 5.00
122 INT24326 Gene_expression of Ngf 346 0.78 218.67 184.71 5.00
123 INT4937 Negative_regulation of Oprd1 224 0.59 44.51 171.11 5.00
124 INT768 Positive_regulation of Oprl1 179 0.70 40.05 156.93 5.00
125 INT1273 Gene_expression of Avp 356 0.78 90.56 138.7 5.00
126 INT5842 Gene_expression of Gfap 372 0.78 153.71 127.71 5.00
127 INT85640 Gene_expression of Tg(CAG-EGFP)D4Nagy 1138 0.72 311.58 119.18 5.00
128 INT5010 Gene_expression of Calca 197 0.78 85.76 118.75 5.00
129 INT92669 Gene_expression of Bdnf 309 0.78 178.26 116.68 5.00
130 INT114 Binding of Oprl1 139 0.48 23 103.35 5.00
131 INT5940 Negative_regulation of Avp 236 0.59 67.86 101.2 5.00
132 INT397 Localization of SST 232 0.81 58.05 101.19 5.00
133 INT1760 Gene_expression of PTGER2 524 0.57 226.94 96.4 5.00
134 INT11587 Gene_expression of CSF2 645 0.78 544.38 93.89 5.00
135 INT9516 Negative_regulation of Gabrg1 149 0.53 27.83 91.02 5.00
136 INT1639 Negative_regulation of OPRM1 107 0.59 13.86 90.37 5.00
137 INT21793 Positive_regulation of Ngf 154 0.70 94.78 85.27 5.00
138 INT12476 Negative_regulation of TRPV1 124 0.59 47.95 77.98 5.00
139 INT1724 Negative_regulation of ACE 437 0.59 315.64 74.48 5.00
140 INT14049 Positive_regulation of GRIN1 102 0.70 48.31 71.06 5.00
141 INT15913 Negative_regulation of CYP2D6 174 0.59 22.45 70.91 5.00
142 INT5843 Positive_regulation of Gfap 184 0.70 108.2 70.21 5.00
143 INT4960 Positive_regulation of CSF2 285 0.70 256.73 65.73 5.00
144 INT12175 Positive_regulation of PDYN 86 0.69 18.27 62.04 5.00
145 INT11318 Gene_expression of Gtf3a 274 0.52 183.82 60.89 5.00
146 INT66779 Binding of Pnoc 79 0.48 6.43 60.46 5.00
147 INT546 Binding of ALB 311 0.48 85.98 60.14 5.00
148 INT66040 Positive_regulation of Bdnf 114 0.69 67.67 51.81 5.00
149 INT4985 Positive_regulation of Tac1 81 0.69 35.79 50.67 5.00
150 INT16850 Negative_regulation of Localization of Gabrg1 73 0.51 8.28 47.89 5.00
151 INT9383 Localization of TRPV1 98 0.81 33.23 46.24 5.00
152 INT8713 Regulation of Tac1 56 0.60 25.29 45.94 5.00
153 INT4004 Gene_expression of IGHG3 321 0.71 221.03 42.33 5.00
154 INT102902 Gene_expression of Ntrk2 152 0.78 81.52 39.43 5.00
155 INT3758 Gene_expression of ALB 326 0.78 184.65 38.75 5.00
156 INT20210 Localization of Ngf 69 0.79 46.22 38.57 5.00
157 INT56870 Gene_expression of CYP2D6 87 0.78 8.83 37.53 5.00
158 INT48693 Regulation of VEGFA 268 0.62 191.88 31.52 5.00
159 INT11554 Negative_regulation of CSF2 129 0.59 108.55 29.44 5.00
160 INT169180 Binding of SNRNP70 204 0.47 119.1 29.3 5.00
161 INT67912 Gene_expression of GRIN1 75 0.77 28.99 29.28 5.00
162 INT102206 Regulation of Bdnf 37 0.62 28.54 28.78 5.00
163 INT12129 Gene_expression of CYP3A4 107 0.78 23.11 27.6 5.00
164 INT1761 Positive_regulation of PTGER2 135 0.49 90.17 26.26 5.00
165 INT63769 Regulation of Ngf 44 0.62 21.82 25.84 5.00
166 INT11159 Gene_expression of EGFR 698 0.78 548.93 25.69 5.00
167 INT57192 Binding of Ltp 43 0.41 17.48 24.96 5.00
168 INT48240 Binding of Ngf 46 0.46 23.51 24.42 5.00
169 INT49553 Regulation of Gene_expression of Gfap 42 0.62 17.04 23.65 5.00
170 INT129157 Positive_regulation of Atf3 48 0.69 35.42 22.87 5.00
171 INT50970 Positive_regulation of Ntrk1 51 0.57 29.38 22.83 5.00
172 INT113925 Localization of Bdnf 59 0.79 24.03 22.76 5.00
173 INT8358 Negative_regulation of Localization of CALCA 25 0.59 11.79 21.51 5.00
174 INT48692 Binding of VEGFA 345 0.48 210.3 21.31 5.00
175 INT30887 Negative_regulation of Ngf 56 0.59 32.96 20.86 5.00
176 INT99237 Gene_expression of Ntrk3 84 0.77 38.68 20.77 5.00
177 INT1764 Negative_regulation of Gene_expression of PTGER2 81 0.34 34.74 19.45 5.00
178 INT40811 Binding of OPRL1 26 0.48 2.76 18.68 5.00
179 INT3952 Negative_regulation of ALB 116 0.59 72.18 18.35 5.00
180 INT68347 Negative_regulation of Cyp2d4 34 0.58 7.62 18.35 5.00
181 INT35487 Localization of PTGER2 103 0.46 51.24 17.45 5.00
182 INT50579 Binding of CYP3A4 84 0.48 17.52 17.45 5.00
183 INT97871 Gene_expression of Ntf3 47 0.78 25.9 15.94 5.00
184 INT129 Localization of OXTR 51 0.80 11.08 15.36 5.00
185 INT79149 Gene_expression of CSE 26 0.58 11.76 14.16 5.00
186 INT20632 Gene_expression of TNC 72 0.78 30.43 13.16 5.00
187 INT5987 Positive_regulation of Positive_regulation of Oprl1 11 0.49 2.81 12.57 5.00
188 INT89395 Negative_regulation of AKT1 127 0.58 70.27 12.54 5.00
189 INT31341 Positive_regulation of CSE 15 0.60 11.57 12.29 5.00
190 INT11141 Negative_regulation of Gene_expression of Avp 23 0.59 3.85 12.19 5.00
191 INT1763 Regulation of Gene_expression of PTGER2 43 0.36 23.98 10.95 5.00
192 INT7132 Localization of NPPA 53 0.81 19.79 10.86 5.00
193 INT167964 Gene_expression of Aes 30 0.58 25.41 10.16 5.00
194 INT33957 Positive_regulation of OPRL1 14 0.68 2.89 9.72 5.00
195 INT95342 Gene_expression of GRIN2B 21 0.75 4.99 9.32 5.00
196 INT108384 Binding of Ntrk1 28 0.39 10.73 9.09 5.00
197 INT53288 Binding of OPN1LW 5 0.11 4.24 8.9 5.00
198 INT52243 Phosphorylation of Ltp 13 0.54 2.84 8.7 5.00
199 INT102658 Negative_regulation of Gene_expression of CSF2 42 0.50 38.63 8.32 5.00
200 INT79166 Regulation of TNC 12 0.44 9.42 8.13 5.00
Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox