P:Buprenorphine

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pChart

Pain Term
Category Drug
Synonyms None
Pain Specific Yes
Documents 3168
Hot Single Events 200
Hot Interactions 21

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported for Buprenorphine. They are ordered first by their pain relevance and then by number of times they were reported for Buprenorphine. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT131314 crz Regulation of Oprl1 1 0.06 0.08 1.08 100.00
2 INT161148 ALB Regulation of Gene_expression of COMMD3 1 0.08 0 0.17 100.00
3 INT161144 MPG Regulation of Gene_expression of COMMD3 1 0.14 0 0.17 100.00
4 INT161147 ORM2 Regulation of Gene_expression of COMMD3 1 0.05 0 0.17 100.00
5 INT161143 MPG Regulation of ALB 1 0.16 0 0.17 100.00
6 INT161145 ORM2 Regulation of ALB 1 0.06 0 0.17 100.00
7 INT161142 ORM2 Regulation of OXA1L 1 0.10 0 0.17 100.00
8 INT161146 MPG Regulation of OXA1L 1 0.27 0 0.17 100.00
9 INT114432 Oprl1 Positive_regulation of Akt1 1 0.18 0.08 2.2 99.60
10 INT95045 Binding of Commd3 and Oprl1 1 0.34 0 1.16 99.12
11 INT91538 Pomc Positive_regulation of P9Ehs1 6 0.11 1.47 6.23 99.06
12 INT161149 ALB Regulation of OXA1L 1 0.15 0 0.17 98.88
13 INT76877 Binding of Slc3a1 and Slc8a1 1 0.02 0 0.64 98.40
14 INT150621 Binding of Oprm1 and Oprd1 1 0.00 0.08 1.02 97.84
15 INT111828 UPB1 Positive_regulation of Oprm1 1 0.00 0.85 1.53 97.16
16 INT160879 POMC Positive_regulation of DECR1 1 0.04 0.08 1.02 93.96
17 INT315334 Binding of CYP3A4 and CDIPT 3 0.04 0.85 0.59 92.00
18 INT107331 Binding of PPBP and Adarb1 1 0.01 0 3.67 88.80
19 INT73071 Binding of Cpe and Insrr 3 0.01 0.33 3.38 82.16
20 INT73072 Negative_regulation of Binding of Cpe and Insrr 1 0.00 0 1.94 82.16
21 INT73920 Binding of CCNT1 and CYP2B6 1 0.19 0.17 0.56 82.08
22 INT168715 Mapk8 Negative_regulation of Oprk1 1 0.18 0.26 1.75 73.40
23 INT168717 Mapk8 Positive_regulation of Mapk8 Negative_regulation of Oprk1 1 0.19 0.26 1.75 73.40
24 INT168716 Mapk8 Negative_regulation of Insrr 1 0.01 0.25 1.75 73.40
25 INT57823 Binding of Trim13 and Atxn2l 1 0.00 0.08 1.17 69.12
26 INT34444 Binding of Oprl1 and Ptprg 4 0.03 0.18 4.58 68.16
27 INT318039 CDIPT Positive_regulation of CYP3A4 1 0.06 0.06 0.2 66.80
28 INT57824 Binding of Trim13 and Slc25a2 1 0.01 0.08 1.19 65.76
29 INT57822 Binding of Slc25a2 and Atxn2l 1 0.00 0.08 1.17 62.96
30 INT351281 AP1M2 Regulation of NCOR2 1 0.00 0.85 1.9 60.64
31 INT107330 Binding of Adarb1 and Trh 1 0.01 0 0.65 56.16
32 INT161150 OXA1L Regulation of Gene_expression of COMMD3 1 0.11 0 0 50.00
33 INT66535 Binding of Pnoc and Oprl1 43 0.54 5.93 32.4 48.48
34 INT76776 Binding of Pnoc and Ptprg 2 0.02 0 2.29 48.48
35 INT160880 Pld2 Positive_regulation of Oprm1 1 0.07 0.08 0.63 47.16
36 INT160882 Pld2 Positive_regulation of Gene_expression of Oprm1 1 0.06 0.08 0.63 47.16
37 INT70836 Positive_regulation of OPRK1 Positive_regulation of Binding of CRYGS 1 0.03 0.09 0.36 26.00
38 INT160881 Positive_regulation of Oprm1 Positive_regulation of Positive_regulation of Pld2 1 0.05 0.08 0.48 25.00
39 INT254001 Binding of Cxcr4 and Mif 1 0.52 14.17 7.18 14.72
40 INT131249 Binding of Bdnf and Ntrk2 11 0.41 4 6.25 5.00
41 INT166134 Binding of Cxcl12 and Cxcr4 3 0.49 5.69 3.17 5.00
42 INT253988 Binding of Cd74 and Mif 1 0.36 6.57 2.52 5.00
43 INT241750 Binding of CD4 and ITIH4 14 0.18 5.72 1.53 5.00
44 INT222335 Binding of Bdnf and Ngfr 3 0.05 2.66 1.48 5.00
45 INT253999 Binding of Cxcl12 and Mif 1 0.41 2.26 1.22 5.00
46 INT184402 Binding of HLA-DRB4 and HLA-E 1 0.00 3.1 1.19 5.00
47 INT276964 Binding of Tlr1 and Tlr2 11 0.24 4.22 0.89 5.00
48 INT253992 Cxcl12 Positive_regulation of Mif 1 0.46 1.31 0.88 5.00
49 INT254004 Cxcl12 Positive_regulation of Cxcr4 1 0.47 1.29 0.86 5.00
50 INT253995 Binding of Cxcl12 and Cyp3a23/3a1 1 0.06 1.28 0.85 5.00
51 INT276988 Binding of Tlr6 and Tlr2 11 0.26 4.89 0.79 5.00
52 INT253994 Cyp3a23/3a1 Positive_regulation of Localization of Mif 1 0.09 0.96 0.69 5.00
53 INT259776 Fbn2 Regulation of Negative_regulation of Agtr1a 1 0.00 1.42 0.66 5.00
54 INT259768 Positive_regulation of Agtr1a Regulation of Etf1 1 0.00 1.32 0.62 5.00
55 INT139901 Ins1 Positive_regulation of Akt1 9 0.31 4.58 0.6 5.00
56 INT253998 Cyp3a23/3a1 Positive_regulation of Binding of Cxcl12 1 0.10 0.65 0.55 5.00
57 INT253990 Cyp3a23/3a1 Positive_regulation of Cxcl12 1 0.09 0.65 0.55 5.00
58 INT184405 CRP Positive_regulation of Gene_expression of ASF1A 1 0.03 1.17 0.49 5.00
59 INT253997 Binding of Cd200r1 and Mif 1 0.03 1.02 0.46 5.00
60 INT349853 Binding of Hspb1 and Jun 1 0.14 2.3 0.45 5.00
61 INT297689 Atn1 Regulation of Gene_expression of Il6 1 0.02 1.13 0.44 5.00
62 INT247639 Binding of Jun and Atf3 2 0.09 3.06 0.44 5.00
63 INT317033 Binding of Caml and Tmub1 1 0.33 0.25 0.44 5.00
64 INT253996 Binding of Cxcr2 and Cxcr4 1 0.18 0.81 0.44 5.00
65 INT297694 Positive_regulation of Binding of Il10 and Il13ra1 1 0.01 1.12 0.44 5.00
66 INT347563 Abat Positive_regulation of Gopc 1 0.04 0.2 0.43 5.00
67 INT297696 Binding of Il10 and Il13ra1 1 0.00 1.12 0.43 5.00
68 INT184407 Binding of HLA-DRB1 and HLA-DRB4 2 0.09 2.26 0.4 5.00
69 INT184406 Binding of HLA-DRB1 and HLA-E 1 0.00 1.03 0.4 5.00
70 INT276216 Binding of Akt1 and Ins1 2 0.03 2.61 0.4 5.00
71 INT336340 Glp2r Positive_regulation of Gene_expression of TGFB1 1 0.14 0.67 0.39 5.00
72 INT204893 Regulation of Tlr4 Positive_regulation of gr 1 0.11 0.9 0.38 5.00
73 INT204905 Tlr4 Positive_regulation of gr 1 0.18 0.9 0.38 5.00
74 INT263072 Kncn Regulation of Transcription of Trpm8 1 0.08 0.99 0.36 5.00
75 INT226785 Angpt2 Positive_regulation of Localization of Lep 1 0.01 1.65 0.36 5.00
76 INT336339 Glp2r Positive_regulation of Timp1 1 0.16 1.82 0.36 5.00
77 INT336336 Il10 Regulation of Il13 1 0.04 0.67 0.34 5.00
78 INT238261 pma Positive_regulation of Prkcg 1 0.01 0.33 0.34 5.00
79 INT309192 Binding of Car2 and Rbms1 1 0.05 0 0.34 5.00
80 INT263090 Negative_regulation of Binding of FDX1 and LH 1 0.02 0.95 0.32 5.00
81 INT263091 Binding of FDX1 and LH 1 0.02 0.95 0.32 5.00
82 INT280926 Hoxa3 Positive_regulation of Gene_expression of Ccl2 1 0.53 2.61 0.32 5.00
83 INT347562 Abat Positive_regulation of Mki67 1 0.03 0 0.3 5.00
84 INT220388 Gh1 Regulation of Cish 1 0.03 0.29 0.28 5.00
85 INT336335 Glp2r Regulation of Mmp13 1 0.06 0.68 0.28 5.00
86 INT220380 Il6 Positive_regulation of Gene_expression of Igfbp1 1 0.09 0.29 0.27 5.00
87 INT220381 Il1a Positive_regulation of Gene_expression of Igfbp1 1 0.01 0.28 0.27 5.00
88 INT220390 TNF Positive_regulation of Gene_expression of Igfbp1 1 0.02 0.29 0.27 5.00
89 INT254000 Regulation of Binding of Cxcr4 and Mif 1 0.29 0.56 0.27 5.00
90 INT238263 pma Positive_regulation of Gene_expression of Cd59 1 0.02 0.57 0.26 5.00
91 INT184404 CRP Regulation of Gene_expression of KRT20 1 0.02 1.21 0.24 5.00
92 INT184403 Positive_regulation of GOPC Regulation of Gene_expression of KRT20 1 0.00 1.21 0.24 5.00
93 INT238260 Positive_regulation of pma Negative_regulation of Transcription of C3 1 0.02 0.12 0.23 5.00
94 INT178720 NOVA2 Regulation of Fig4 1 0.01 0 0.23 5.00
95 INT318620 Mog Regulation of Mbp 1 0.05 0.85 0.23 5.00
96 INT317034 Binding of GRIP1 and Tmub1 1 0.02 0.11 0.23 5.00
97 INT220383 Binding of Igf1 and Cotl1 1 0.03 0.37 0.22 5.00
98 INT285639 Col3a1 Regulation of Tnfrsf12a 1 0.19 0.16 0.22 5.00
99 INT285640 Eln Regulation of Tnfrsf12a 1 0.14 0.16 0.22 5.00
100 INT241822 Binding of CD4 and HIVEP1 3 0.01 2.73 0.21 5.00
101 INT253991 Negative_regulation of Binding of Cxcl12 and Cxcr4 1 0.43 0.41 0.21 5.00
102 INT316203 Ghsr Positive_regulation of Transcription of Agrp 1 0.02 1.5 0.19 5.00
103 INT349855 Atf3 Regulation of Hspb1 1 0.37 0.77 0.19 5.00
104 INT287014 Gabrd Regulation of Ptn 1 0.10 0 0.18 5.00
105 INT300305 Mapk14 Positive_regulation of Gene_expression of Ctgf 1 0.19 1.25 0.17 5.00
106 INT193562 Nr1i3 Positive_regulation of Hspg2 1 0.00 0 0.17 5.00
107 INT220387 Gh1 Regulation of Localization of Igf1 1 0.05 0.3 0.17 5.00
108 INT238264 pma Negative_regulation of Gene_expression of Cr1l 1 0.02 0.26 0.16 5.00
109 INT238222 pma Positive_regulation of Prkcg Negative_regulation of Gene_expression of Cr1l 1 0.01 0.26 0.16 5.00
110 INT238262 Prkcg Negative_regulation of Gene_expression of Cr1l 1 0.12 0.26 0.16 5.00
111 INT349861 Gfra1 Negative_regulation of Ntrk1 1 0.01 0.36 0.15 5.00
112 INT349850 Gfra1 Negative_regulation of Adcyap1r1 1 0.15 0.36 0.15 5.00
113 INT349852 Gfra2 Negative_regulation of Ntrk1 1 0.27 0.3 0.15 5.00
114 INT349859 Gfra2 Negative_regulation of Ntrk1 1 0.02 0.3 0.15 5.00
115 INT349862 Gfra3 Negative_regulation of Ntrk1 1 0.02 0.3 0.15 5.00
116 INT349851 Gfra3 Negative_regulation of Adcyap1r1 1 0.28 0.31 0.15 5.00
117 INT349849 Gfra2 Negative_regulation of Adcyap1r1 1 0.33 0.31 0.15 5.00
118 INT349856 Gfra3 Negative_regulation of Ntrk1 1 0.23 0.3 0.15 5.00
119 INT349857 Gfra2 Negative_regulation of Gfra3 1 0.20 0.3 0.15 5.00
120 INT349854 Gfra1 Negative_regulation of Ntrk1 1 0.12 0.36 0.15 5.00
121 INT336337 Glp2r Positive_regulation of Gene_expression of Col2a1 1 0.01 0.7 0.14 5.00
122 INT220385 Binding of Igf1 and Gnrhr 1 0.05 0.99 0.14 5.00
123 INT220386 Binding of Gh1 and Igf1 1 0.07 0.99 0.14 5.00
124 INT300512 Binding of Plau and Vtn 1 0.06 2.28 0.13 5.00
125 INT238258 C7 Negative_regulation of C6 1 0.09 0.24 0.13 5.00
126 INT300511 Binding of Plaur and Vtn 1 0.10 2.28 0.13 5.00
127 INT254002 Binding of Cyp3a23/3a1 and Positive_regulation of Gene_expression of Mif 1 0.08 0.56 0.13 5.00
128 INT300513 Binding of Serpine1 and Vtn 1 0.17 2.27 0.13 5.00
129 INT330156 Scn2a1 Regulation of Transcription of Pcsk1n 1 0.13 0 0.13 5.00
130 INT238259 Regulation of C7 Negative_regulation of C6 1 0.06 0.24 0.13 5.00
131 INT324082 CD40 Positive_regulation of MAPK9 1 0.21 0.64 0.13 5.00
132 INT298548 Itgam Regulation of Fig4 1 0.08 0.05 0.12 5.00
133 INT317031 Caml Positive_regulation of Gene_expression of Eltd1 1 0.04 0.1 0.12 5.00
134 INT297695 Binding of Atn1 and Fut1 1 0.01 0.68 0.12 5.00
135 INT204883 gr Negative_regulation of Lcn2 1 0.07 0.15 0.11 5.00
136 INT204888 Binding of Cp and Tlr4 1 0.29 0.49 0.11 5.00
137 INT349858 Binding of Ngfr and Ntrk2 1 0.09 0.32 0.11 5.00
138 INT204882 gr Negative_regulation of Saa3 1 0.07 0.15 0.11 5.00
139 INT216075 ATD Regulation of Cfp 1 0.07 0.11 0.11 5.00
140 INT300313 TGFB1 Positive_regulation of Mapk14 1 0.01 1.5 0.11 5.00
141 INT300306 Agt Positive_regulation of Mapk14 1 0.14 1.51 0.11 5.00
142 INT219788 Binding of Csrp1 and Fgg 1 0.02 0.11 0.1 5.00
143 INT204878 Gem Positive_regulation of Tlr4 1 0.20 0.1 0.1 5.00
144 INT204901 Tnfsf9 Positive_regulation of Tlr4 1 0.27 0.1 0.1 5.00
145 INT204877 gr Negative_regulation of Serpina3n 1 0.23 0.15 0.1 5.00
146 INT349860 Binding of Cntf and Lifr 1 0.39 0.22 0.1 5.00
147 INT204890 Cd83 Positive_regulation of Tlr4 1 0.25 0.1 0.1 5.00
148 INT349340 SRI Regulation of Rpe 1 0.02 0.05 0.09 5.00
149 INT204897 Tlr4 Positive_regulation of Il1b 1 0.21 0.09 0.09 5.00
150 INT204898 Negative_regulation of Tlr4 Negative_regulation of Ch25h 1 0.21 0.09 0.09 5.00
151 INT204886 Tlr4 Negative_regulation of Negative_regulation of C1qa 1 0.21 0.09 0.09 5.00
152 INT204894 Tlr4 Positive_regulation of Ch25h 1 0.23 0.09 0.09 5.00
153 INT317032 Binding of Caml and Ppib 1 0.06 0.08 0.09 5.00
154 INT204899 Tlr4 Positive_regulation of Cd44 1 0.23 0.09 0.09 5.00
155 INT294637 Bcl2a1a Positive_regulation of Gene_expression of Bcl2 1 0.15 0.97 0.09 5.00
156 INT204892 Tlr4 Positive_regulation of C1qa 1 0.23 0.09 0.09 5.00
157 INT204904 Tlr4 Positive_regulation of Hexb 1 0.14 0.09 0.09 5.00
158 INT257870 Agt Positive_regulation of Akt1 2 0.18 1.5 0.09 5.00
159 INT204885 Tlr4 Negative_regulation of Positive_regulation of Cd44 1 0.21 0.09 0.09 5.00
160 INT204884 Tlr4 Negative_regulation of Negative_regulation of Hexb 1 0.13 0.09 0.09 5.00
161 INT204902 Negative_regulation of Tlr4 Positive_regulation of Stat1 1 0.23 0.09 0.09 5.00
162 INT204879 Tlr4 Positive_regulation of Stat1 1 0.25 0.09 0.09 5.00
163 INT204895 Tlr4 Positive_regulation of Gene_expression of Cp 1 0.38 0.47 0.09 5.00
164 INT204889 Tlr4 Negative_regulation of Cd44 1 0.10 0.09 0.09 5.00
165 INT300304 Positive_regulation of Mapk14 Positive_regulation of Agt 1 0.14 1.5 0.08 5.00
166 INT320354 IFNA1 Regulation of Cd69 1 0.01 0.2 0.07 5.00
167 INT204880 Tlr4 Positive_regulation of Cp 1 0.56 0.63 0.07 5.00
168 INT204896 Tlr4 Negative_regulation of Ch25h 1 0.21 0.09 0.07 5.00
169 INT204891 Tlr4 Negative_regulation of Stat1 1 0.10 0.09 0.07 5.00
170 INT226787 Trglyd Positive_regulation of Lbp 1 0.04 1.67 0.07 5.00
171 INT294638 Bcl2a1a Positive_regulation of Tlr2 1 0.58 0.43 0.07 5.00
172 INT226786 Scl1 Positive_regulation of Lbp 1 0.04 1.68 0.07 5.00
173 INT300308 Positive_regulation of Mapk14 Positive_regulation of Trib3 1 0.03 1.42 0.07 5.00
174 INT300309 Akt1 Regulation of Rorb 1 0.05 3.28 0.06 5.00
175 INT225262 Egf Regulation of Gene_expression of S100a7a 1 0.04 3.31 0.06 5.00
176 INT300310 Akt1 Regulation of Foxo3 1 0.21 1.5 0.06 5.00
177 INT336338 Glp2r Positive_regulation of Gene_expression of Igf1 1 0.14 0.24 0.05 5.00
178 INT219787 Binding of Col7a1 and Csrp1 1 0.02 0.06 0.05 5.00
179 INT219789 Binding of Serpinc1 and Csrp1 1 0.02 0.06 0.05 5.00
180 INT320353 IFNA1 Positive_regulation of Gene_expression of Ighg2b 1 0.02 0 0.05 5.00
181 INT219786 Binding of Col7a1 and Fgg 1 0.00 0.06 0.05 5.00
182 INT204903 Gopc Positive_regulation of Gene_expression of Cp 1 0.16 0.26 0.05 5.00
183 INT225261 S100a7a Positive_regulation of Egf 1 0.07 1.13 0.05 5.00
184 INT219784 Binding of Serpinc1 and Fgg 1 0.00 0.06 0.05 5.00
185 INT219783 Binding of Serpinc1 and Col7a1 1 0.00 0.06 0.05 5.00
186 INT294639 Bcl2a1a Positive_regulation of Gene_expression of Chkb 1 0.19 1.02 0.04 5.00
187 INT204906 Tlr4 Negative_regulation of Hexb 1 0.13 0.09 0.04 5.00
188 INT241751 Negative_regulation of Binding of CD4 and ITIH4 3 0.18 1.07 0.04 5.00
189 INT329102 Binding of CD4 and HLA-DQA2 2 0.04 0.92 0.04 5.00
190 INT225259 Egfr Regulation of Gene_expression of S100a7a 1 0.04 0.98 0.04 5.00
191 INT204900 Tlr4 Negative_regulation of Il1b 1 0.19 0.09 0.04 5.00
192 INT349339 Rpe Regulation of Per2 1 0.30 0 0.04 5.00
193 INT204887 Tlr4 Negative_regulation of C1qa 1 0.21 0.09 0.04 5.00
194 INT317035 UBQLN1 Regulation of Localization of Gabrg1 1 0.12 0 0.03 5.00
195 INT317959 Negative_regulation of Ephb1 Negative_regulation of Cldn4 1 0.10 0.27 0.03 5.00
196 INT319218 Bmpr2 Negative_regulation of Smad2 1 0.17 0.12 0.03 5.00
197 INT319219 Bmpr2 Positive_regulation of Smad1 1 0.18 0.29 0.03 5.00
198 INT326173 Binding of Eno2 and Cnp 1 0.07 0.94 0.03 5.00
199 INT317961 Negative_regulation of Ephb1 Negative_regulation of Negative_regulation of Cldn4 1 0.10 0.27 0.03 5.00
200 INT349338 Regulation of Rpe Regulation of Gene_expression of Per2 1 0.21 0.06 0.03 5.00

Single Events

The table below shows the top 200 pain related interactions that have been reported for Buprenorphine. They are ordered first by their pain relevance and then by number of times they were reported in Buprenorphine. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT125379 Gene_expression of COMMD3 7 0.49 0 8.19 100.00
2 INT155 Positive_regulation of Prl 1233 0.70 317.93 457.82 100.00
3 INT125378 Gene_expression of UPB1 4 0.59 0.25 4.49 100.00
4 INT114 Binding of Oprl1 139 0.48 23 103.35 100.00
5 INT1212 Binding of Oprl1 312 0.48 28.6 225.15 100.00
6 INT21632 Positive_regulation of Adh1 32 0.70 15.67 11.65 100.00
7 INT21186 Negative_regulation of Binding of Ptprg 28 0.44 1.78 27.04 100.00
8 INT1396 Binding of Penk 355 0.48 22.79 269.65 100.00
9 INT4403 Binding of CYP2B6 113 0.48 21.17 33.83 100.00
10 INT5660 Binding of Oprd1 477 0.48 71.86 342.06 100.00
11 INT162 Regulation of Prl 794 0.62 165.01 322.24 100.00
12 INT915 Positive_regulation of PRL 342 0.70 141.96 104.31 100.00
13 INT253 Regulation of PRL 184 0.62 47.27 65.79 100.00
14 INT154009 Binding of Upb1 1 0.39 0.39 1.54 100.00
15 INT84473 Gene_expression of SARDH 5 0.77 1.21 3.37 100.00
16 INT125380 Positive_regulation of Gene_expression of COMMD3 2 0.21 0 1.47 100.00
17 INT12333 Regulation of CYP3A 18 0.62 2.25 6.74 100.00
18 INT119904 Regulation of CYP19A1 25 0.62 9.36 8.34 100.00
19 INT111112 Negative_regulation of UPB1 2 0.32 0.1 1.68 100.00
20 INT683 Positive_regulation of AVP 173 0.70 74.55 46.41 100.00
21 INT5987 Positive_regulation of Positive_regulation of Oprl1 11 0.49 2.81 12.57 100.00
22 INT16408 Negative_regulation of Nppb 14 0.53 5.49 3.74 100.00
23 INT114187 Regulation of Serpina6 1 0.45 0 1.61 100.00
24 INT2640 Gene_expression of Pomc 424 0.78 120.72 155.37 100.00
25 INT7975 Regulation of PLOD1 97 0.62 20.9 30.51 100.00
26 INT78889 Binding of UGT1A1 10 0.47 3.41 1.47 100.00
27 INT163715 Positive_regulation of Negative_regulation of COMMD3 1 0.30 0 0.96 100.00
28 INT163717 Negative_regulation of COMMD3 1 0.37 0 0.95 100.00
29 INT26472 Regulation of Oprm1 191 0.62 35.84 173.1 100.00
30 INT20450 Regulation of Binding of Penk 11 0.60 0.47 11.92 100.00
31 INT163716 Positive_regulation of COMMD3 1 0.32 0 0.89 100.00
32 INT1977 Negative_regulation of Positive_regulation of Prl 98 0.59 17.06 47.88 100.00
33 INT116131 Gene_expression of Commd3 2 0.53 0.68 1.21 100.00
34 INT7055 Positive_regulation of Binding of FAIM3 4 0.34 1.22 4.34 100.00
35 INT5690 Negative_regulation of Binding of Oprd1 36 0.59 8.29 24.52 100.00
36 INT165982 Regulation of UPB1 1 0.33 0.08 0.9 100.00
37 INT136145 Regulation of Ncr1 1 0.23 0.26 1.72 100.00
38 INT3933 Positive_regulation of PLOD1 128 0.70 30.76 42.03 100.00
39 INT1652 Regulation of Pomc 387 0.62 61.01 186.51 100.00
40 INT16654 Gene_expression of Insrr 138 0.46 58.96 75.68 100.00
41 INT2780 Regulation of Gene_expression of Penk 265 0.62 32.45 143.88 100.00
42 INT797 Regulation of Penk 812 0.62 111.13 542.24 100.00
43 INT197197 Localization of DURS1 1 0.49 0 0.9 100.00
44 INT10304 Binding of OPRK1 89 0.48 9.28 49.42 100.00
45 INT162410 Binding of Bhd 1 0.09 0.45 0.61 100.00
46 INT162411 Gene_expression of Bhd 1 0.16 0.44 0.6 100.00
47 INT50581 Regulation of PPIG 26 0.55 8.96 4.32 100.00
48 INT72011 Positive_regulation of Binding of Ptprg 42 0.50 2.72 39.89 99.98
49 INT6406 Binding of Oprm1 280 0.48 40.54 226.26 99.98
50 INT50579 Binding of CYP3A4 84 0.48 17.52 17.45 99.98
51 INT26248 Positive_regulation of Ptprg 12 0.40 1.42 9.48 99.98
52 INT40811 Binding of OPRL1 26 0.48 2.76 18.68 99.98
53 INT4941 Positive_regulation of Oprd1 345 0.70 74.26 304.41 99.98
54 INT12501 Positive_regulation of Adarb1 166 0.58 36.94 118.92 99.98
55 INT4805 Positive_regulation of Localization of TPSAB1 9 0.55 0.32 5.38 99.98
56 INT165981 Negative_regulation of UGT1A3 1 0.58 0.17 1.79 99.98
57 INT59309 Negative_regulation of Gene_expression of ADCY1 3 0.42 1.04 2.98 99.98
58 INT33957 Positive_regulation of OPRL1 14 0.68 2.89 9.72 99.98
59 INT66779 Binding of Pnoc 79 0.48 6.43 60.46 99.98
60 INT73067 Binding of Om 8 0.08 2.35 2.56 99.98
61 INT20052 Negative_regulation of UGT1A1 12 0.58 4.51 4.29 99.98
62 INT29290 Regulation of Gene_expression of PRL 13 0.49 6.46 5.23 99.98
63 INT7974 Regulation of Gene_expression of PLOD1 6 0.42 0.41 1.99 99.98
64 INT1648 Regulation of LHB 21 0.61 3.32 9.6 99.98
65 INT5771 Binding of Oprd1 37 0.48 2.6 27.54 99.98
66 INT110551 Negative_regulation of Negative_regulation of CYP2D6 3 0.40 0.25 1.38 99.98
67 INT17546 Negative_regulation of Ngf 135 0.59 60.28 77.19 99.98
68 INT64563 Gene_expression of UGT1A1 27 0.75 3.31 13.43 99.96
69 INT67585 Gene_expression of UGT2B7 52 0.78 2.33 24.13 99.96
70 INT75773 Gene_expression of UGT1A3 12 0.78 1.75 3.54 99.96
71 INT739 Negative_regulation of POMC 358 0.59 102.28 166.77 99.94
72 INT21185 Binding of Ptprg 213 0.47 13.49 157.75 99.92
73 INT75421 Regulation of Binding of Ptprg 13 0.44 0.96 12.64 99.92
74 INT4726 Negative_regulation of PPT1 15 0.57 10.09 14.17 99.92
75 INT6293 Gene_expression of Oprm1 312 0.78 48.73 215.61 99.92
76 INT5895 Gene_expression of Oprm1 525 0.78 120.67 407.29 99.92
77 INT796 Gene_expression of Penk 1902 0.78 275.47 1057.59 99.92
78 INT4658 Binding of OPRM1 188 0.48 25.96 136.24 99.90
79 INT70877 Gene_expression of PPIG 72 0.75 22.39 10.93 99.90
80 INT44851 Gene_expression of RT1-DMb 3 0.52 2.2 2.1 99.90
81 INT4804 Positive_regulation of Gene_expression of PTGDS 10 0.68 21.43 11.14 99.88
82 INT4811 Positive_regulation of Gene_expression of LTC4S 5 0.65 3.29 2.92 99.88
83 INT1414 Regulation of Oprl1 169 0.62 32.05 139.99 99.88
84 INT74508 Gene_expression of Gypa 7 0.75 2.15 2.89 99.88
85 INT168714 Negative_regulation of Binding of Mapk8 1 0.36 0.18 1.62 99.88
86 INT53393 Positive_regulation of Cyp3a62 25 0.70 7.56 17.69 99.84
87 INT528 Gene_expression of Prl 693 0.78 217.18 192.2 99.84
88 INT871 Negative_regulation of Gene_expression of Prl 53 0.58 18.89 17.79 99.84
89 INT33225 Gene_expression of Cga 4 0.75 0.09 1.65 99.84
90 INT11560 Positive_regulation of CASP3 236 0.70 184.33 39.38 99.84
91 INT75496 Positive_regulation of MCF2 7 0.08 3.86 0.38 99.84
92 INT5931 Regulation of Oprm1 149 0.62 18.15 125.93 99.82
93 INT8792 Gene_expression of GBA 20 0.78 14.73 1.98 99.82
94 INT10796 Gene_expression of CYP2B6 131 0.77 30.14 35.27 99.80
95 INT12129 Gene_expression of CYP3A4 107 0.78 23.11 27.6 99.80
96 INT8764 Positive_regulation of Positive_regulation of Cyp3a23/3a1 5 0.45 1.62 3.33 99.80
97 INT12602 Negative_regulation of Oprm1 190 0.59 36.11 177.85 99.76
98 INT7057 Binding of FAIM3 19 0.48 4.02 13.78 99.76
99 INT7970 Gene_expression of PLOD1 120 0.71 44.42 15.54 99.76
100 INT29971 Gene_expression of Oprk1 126 0.78 35.32 93.97 99.74
101 INT4759 Negative_regulation of Localization of Calca 294 0.59 82.62 226.45 99.74
102 INT1639 Negative_regulation of OPRM1 107 0.59 13.86 90.37 99.70
103 INT269719 Positive_regulation of Localization of FAIM3 1 0.17 0.22 2.36 99.70
104 INT82540 Negative_regulation of TFRC 3 0.41 0.77 1.07 99.70
105 INT768 Positive_regulation of Oprl1 179 0.70 40.05 156.93 99.68
106 INT12575 Regulation of Hpse 33 0.59 17.7 18.45 99.68
107 INT5453 Regulation of Localization of POMC 114 0.62 20.56 56.34 99.68
108 INT109316 Negative_regulation of Mapk8 72 0.59 50.59 17.24 99.66
109 INT109313 Binding of Mapk8 6 0.48 1.78 1.98 99.66
110 INT56224 Negative_regulation of Gene_expression of Ifng 40 0.58 23.34 25.08 99.64
111 INT15913 Negative_regulation of CYP2D6 174 0.59 22.45 70.91 99.62
112 INT50405 Negative_regulation of CYP3A4 238 0.59 53.65 51.51 99.62
113 INT1579 Gene_expression of PRL 279 0.78 119.2 55.41 99.62
114 INT93129 Negative_regulation of KCNH2 42 0.54 9.63 10.85 99.62
115 INT18893 Positive_regulation of CPP 81 0.69 38.03 34.33 99.60
116 INT103924 Positive_regulation of Akt1 359 0.69 158.94 60.34 99.60
117 INT141434 Positive_regulation of SUCLG1 2 0.49 0.74 1.18 99.60
118 INT4758 Positive_regulation of Localization of Calca 557 0.70 138.55 411.04 99.58
119 INT73251 Regulation of UGT2B7 5 0.62 0.21 3.35 99.58
120 INT4806 Localization of TPSAB1 29 0.80 5.05 10.52 99.56
121 INT4809 Gene_expression of PTGDS 103 0.76 52.94 24.01 99.56
122 INT4808 Gene_expression of LTC4S 37 0.73 18.36 9.62 99.56
123 INT111272 Gene_expression of ERPL1 3 0.14 0 2.64 99.54
124 INT125376 Positive_regulation of Gene_expression of ERPL1 1 0.09 0 1.46 99.54
125 INT269718 Localization of FAIM3 1 0.25 0.22 2.35 99.54
126 INT98705 Gene_expression of GTF3C6 1 0.03 0.09 0.71 99.54
127 INT60779 Negative_regulation of CYP3A 63 0.59 8.38 21.27 99.52
128 INT22454 Regulation of Crp 213 0.62 160.67 49.24 99.52
129 INT37390 Regulation of Crp 39 0.46 28.74 11.45 99.52
130 INT2165 Localization of Cga 41 0.80 4.02 19.53 99.48
131 INT125377 Localization of CYP2B6 5 0.78 0.59 2.23 99.48
132 INT13108 Binding of MTG1 35 0.47 6.36 20.5 99.48
133 INT3118 Negative_regulation of Positive_regulation of POMC 33 0.59 9.42 18.07 99.48
134 INT11429 Gene_expression of ADCY1 26 0.74 5.89 11.93 99.46
135 INT158 Localization of Prl 2431 0.81 378.96 952.2 99.44
136 INT47386 Negative_regulation of CHAT 5 0.29 1.63 2.61 99.44
137 INT60438 Localization of MEG8 2 0.60 0.32 2.01 99.44
138 INT159 Negative_regulation of Localization of Prl 416 0.59 55.34 171.8 99.44
139 INT29105 Positive_regulation of OPRK1 68 0.70 7.06 44.69 99.44
140 INT2542 Localization of Calca 2008 0.81 518.3 1408.65 99.42
141 INT18772 Positive_regulation of Gene_expression of CYP2B6 14 0.49 2.93 5.4 99.40
142 INT5930 Positive_regulation of Oprm1 221 0.70 31.19 172.93 99.40
143 INT71047 Gene_expression of CYP19A1 122 0.78 68.78 22.21 99.40
144 INT119909 Binding of Abcb1a 10 0.36 0.76 5.07 99.40
145 INT7872 Positive_regulation of P9Ehs1 74 0.50 18.54 66.16 99.40
146 INT49483 Regulation of Positive_regulation of Oprm1 8 0.61 2.34 9.4 99.40
147 INT5929 Positive_regulation of Regulation of Oprm1 4 0.50 0.56 3.48 99.40
148 INT161 Regulation of Localization of Prl 615 0.62 65.37 298.66 99.38
149 INT2040 Positive_regulation of CYP2B6 95 0.69 34.3 25.6 99.34
150 INT21223 Positive_regulation of Gene_expression of Oprl1 10 0.70 2.21 9.24 99.34
151 INT16396 Negative_regulation of CEBPZ 76 0.48 30.03 21.6 99.32
152 INT1319 Gene_expression of Oprl1 65 0.78 9.34 42.41 99.30
153 INT107329 Gene_expression of Me3 2 0.19 1.42 4.91 99.30
154 INT274394 Negative_regulation of CDIPT 3 0.08 2.57 3.98 99.28
155 INT4807 Localization of LTC4S 23 0.58 6.89 7.59 99.28
156 INT4810 Localization of PTGDS 20 0.81 4.19 6.97 99.28
157 INT8775 Binding of IGHE 167 0.48 102.61 23.54 99.28
158 INT24871 Negative_regulation of Binding of IGHE 10 0.58 2.87 2.64 99.28
159 INT9199 Positive_regulation of CEBPZ 111 0.67 30.99 28.45 99.28
160 INT1638 Negative_regulation of PLOD1 92 0.59 21.69 26.61 99.26
161 INT8765 Positive_regulation of Cyp3a23/3a1 63 0.67 22.28 20.39 99.26
162 INT1603 Negative_regulation of Rtcd1 131 0.51 29.99 66.66 99.26
163 INT4485 Negative_regulation of Positive_regulation of PRL 11 0.43 4.24 3.89 99.26
164 INT2055 Regulation of Gnrh1 185 0.62 23.65 71.26 99.26
165 INT9729 Negative_regulation of LHB 14 0.42 1.86 4.63 99.26
166 INT6437 Binding of YY1 154 0.47 26.3 90.46 99.24
167 INT36263 Positive_regulation of CEL 53 0.69 34.88 12.87 99.24
168 INT76741 Localization of OPRK1 7 0.68 0.22 5.9 99.24
169 INT124022 Gene_expression of Ubc 2 0.78 0.5 0.19 99.24
170 INT90020 Gene_expression of SUCLG1 8 0.75 1.61 8.34 99.22
171 INT374 Positive_regulation of Ldha 212 0.70 107.08 47.43 99.20
172 INT1334 Negative_regulation of Binding of Oprl1 29 0.59 3.03 20.62 99.18
173 INT153417 Gene_expression of DDOST 6 0.67 1.81 2.18 99.18
174 INT16769 Positive_regulation of Positive_regulation of Oprm1 31 0.57 8.29 29.66 99.16
175 INT67810 Regulation of Ugt2b1 1 0.45 0.1 1.26 99.16
176 INT65120 Regulation of Ugt1a1 3 0.45 1.07 3.29 99.16
177 INT38207 Positive_regulation of Tes 7 0.40 3.47 1.7 99.16
178 INT74563 Positive_regulation of Gene_expression of ROS1 258 0.61 168.18 34.08 99.16
179 INT3448 Positive_regulation of Gh 521 0.69 180.03 161.18 99.16
180 INT62523 Positive_regulation of Phosphorylation of Oprm1 11 0.53 0.75 12.51 99.14
181 INT1614 Gene_expression of Oprl1 164 0.78 31.43 127.74 99.12
182 INT99410 Positive_regulation of UGT1A1 10 0.45 2.2 2.07 99.12
183 INT80779 Positive_regulation of Hbb-ar 10 0.41 2.48 3.29 99.12
184 INT35716 Positive_regulation of NCOR2 45 0.60 18 23.54 99.12
185 INT166215 Negative_regulation of Sry 2 0.21 0.33 1 99.10
186 INT57168 Binding of Ugt2b1 2 0.48 0 0.81 99.10
187 INT4340 Positive_regulation of Localization of Ldha 46 0.70 14.52 15.66 99.06
188 INT210326 Binding of DDOST 6 0.48 4.27 6.26 99.00
189 INT67653 Gene_expression of Om 46 0.36 15.28 13.32 98.98
190 INT69440 Gene_expression of ROS1 752 0.78 477.64 103.83 98.98
191 INT5540 Positive_regulation of Oprm1 344 0.70 76.77 319.71 98.96
192 INT62521 Phosphorylation of Oprm1 44 0.82 2.66 47.45 98.96
193 INT157 Positive_regulation of Localization of Prl 790 0.70 104.54 374.78 98.96
194 INT18894 Gene_expression of CPP 44 0.77 23.05 23.05 98.92
195 INT58495 Positive_regulation of Positive_regulation of Oprm1 22 0.49 2.44 17.66 98.92
196 INT3920 Localization of Ldha 241 0.81 83.08 58.72 98.90
197 INT25587 Positive_regulation of Fuca2 5 0.33 1.28 2.9 98.90
198 INT21560 Positive_regulation of Binding of Oprm1 30 0.50 7.16 32.95 98.90
199 INT5979 Gene_expression of Oprd1 428 0.78 75.64 320.32 98.88
200 INT50580 Binding of PPIG 39 0.36 11.17 12.34 98.88
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