P:COX-2 inhibitor

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Pain Term
Category Drug class
Synonyms COX-2 Inhibitors
Pain Specific No
Documents 1796
Hot Single Events 200
Hot Interactions 149

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported for COX-2 inhibitor. They are ordered first by their pain relevance and then by number of times they were reported for COX-2 inhibitor. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT279414 Binding of CPOX and ACTR1B 1 0.04 1.55 0.4 100.00
2 INT207355 ZNF398 Regulation of CYP27A1 1 0.00 0 0.31 100.00
3 INT98346 Negative_regulation of Binding of CPOX and PTGS1 1 0.10 2.91 6.54 100.00
4 INT207339 TBXA2R Negative_regulation of Negative_regulation of CYP27A1 1 0.01 0 0.17 100.00
5 INT207348 TBXA2R Negative_regulation of CPOX 1 0.03 0 0.17 100.00
6 INT207332 PTGER2 Negative_regulation of ZNF398 Regulation of CYP27A1 1 0.00 0 0.14 100.00
7 INT207331 PTGER1 Negative_regulation of ZNF398 Regulation of CYP27A1 1 0.00 0 0.14 100.00
8 INT207353 ZNF398 Regulation of ABCA1 1 0.00 0 0.14 100.00
9 INT207352 ZNF398 Regulation of CPOX 1 0.00 0 0.14 100.00
10 INT207358 PTGDS Negative_regulation of CPOX 1 0.05 0 0.14 100.00
11 INT207341 PTGER2 Negative_regulation of CPOX 1 0.01 0 0.14 100.00
12 INT207347 PTGER1 Negative_regulation of CPOX 1 0.00 0 0.14 100.00
13 INT314270 CPOX Negative_regulation of Gene_expression of PTGER2 1 0.01 0.15 0.17 100.00
14 INT81657 Binding of CPOX and PTGS1 5 0.15 1.9 2.37 100.00
15 INT302170 PTGER2 Positive_regulation of Gene_expression of BCL2 1 0.04 3.76 0.23 100.00
16 INT234599 Cpox Negative_regulation of Gene_expression of Ptgds 1 0.05 0.6 0.44 100.00
17 INT234600 Negative_regulation of Cpox Negative_regulation of Gene_expression of Ptgds 1 0.05 0.6 0.44 100.00
18 INT352196 Igkv12-66 Negative_regulation of Gm10404 1 0.00 1.62 1.34 100.00
19 INT314264 Negative_regulation of CPOX Negative_regulation of Gene_expression of PTGER2 1 0.01 0.15 0.09 100.00
20 INT207360 PTGDS Negative_regulation of Negative_regulation of ABCA1 1 0.25 0 0.14 99.80
21 INT207335 PTGDS Negative_regulation of Negative_regulation of CYP27A1 1 0.02 0 0.14 99.80
22 INT207337 PTGER2 Negative_regulation of Negative_regulation of ABCA1 1 0.04 0 0.14 99.80
23 INT207346 PTGER2 Negative_regulation of Negative_regulation of CYP27A1 1 0.00 0 0.14 99.80
24 INT140966 NFKB1 Positive_regulation of Positive_regulation of CPOX 1 0.08 0.66 0.8 99.78
25 INT157142 OPA1 Positive_regulation of Gene_expression of Camk2a 1 0.02 0.3 1.02 99.68
26 INT295755 Fgf2 Regulation of MMP9 1 0.07 0.99 0.33 99.44
27 INT295717 VEGFA Regulation of MMP9 1 0.01 0.98 0.33 99.44
28 INT203170 Negative_regulation of CPOX Positive_regulation of ALOX5 1 0.01 0.53 0.29 99.12
29 INT107702 DCSTAMP Positive_regulation of Gene_expression of CPOX 1 0.04 0.32 0.75 98.90
30 INT142446 Regulation of CPOX Regulation of Gene_expression of PTGIS 1 0.10 0.26 0.22 98.68
31 INT207359 ZNF398 Negative_regulation of ABCA1 1 0.01 0 0.17 97.40
32 INT207351 ZNF398 Negative_regulation of CYP27A1 1 0.00 0 0.17 97.40
33 INT142448 TNF Positive_regulation of Localization of PTGIS 1 0.35 0.28 0.21 97.28
34 INT203166 Negative_regulation of CPOX Positive_regulation of Gene_expression of LTB4R 1 0.00 0.65 0.34 97.12
35 INT285688 Cpox Positive_regulation of PPARA 1 0.02 1 0.5 96.96
36 INT136758 TNF Positive_regulation of Gene_expression of PTGES 1 0.05 0.52 0.55 96.92
37 INT203169 CPOX Regulation of Gene_expression of PTGER2 2 0.00 0.48 0.29 96.92
38 INT207345 PTGDS Negative_regulation of Gene_expression of ABCA1 1 0.21 0 0.17 96.84
39 INT207342 PTGDS Negative_regulation of Gene_expression of CYP27A1 1 0.02 0 0.17 96.84
40 INT207340 PTGER2 Negative_regulation of Gene_expression of CYP27A1 1 0.00 0 0.17 96.84
41 INT207344 PTGER2 Negative_regulation of Gene_expression of ABCA1 1 0.04 0 0.17 96.84
42 INT103592 CAP1 Negative_regulation of Gene_expression of CPOX 1 0.19 1.52 1.64 96.64
43 INT136759 TNF Positive_regulation of PTGES 1 0.03 0.29 0.28 96.48
44 INT347301 AREG Positive_regulation of CCL16 1 0.01 0.86 0.16 96.20
45 INT172911 Cpox Positive_regulation of Gene_expression of VEGFA 1 0.01 0.72 0.09 96.20
46 INT137017 Tgfb1 Positive_regulation of Gene_expression of Acta2 1 0.00 0.84 0.61 96.12
47 INT137022 Pscs Positive_regulation of Gene_expression of Acta2 1 0.00 0.84 0.61 96.12
48 INT137016 Il6 Positive_regulation of Gene_expression of Acta2 1 0.01 0.75 0.54 96.12
49 INT350072 Ptger2 Positive_regulation of Hmox1 1 0.02 0.2 0.15 95.92
50 INT350081 Pik3r1 Positive_regulation of Hmox1 1 0.07 0.2 0.15 95.68
51 INT350069 Prkaca Positive_regulation of Hmox1 1 0.05 0.2 0.15 95.68
52 INT120716 Binding of AKT1 and TEP1 1 0.05 0.46 0.21 95.52
53 INT145661 Ptger2 Positive_regulation of Gene_expression of VEGFA 4 0.27 2.73 0.6 95.20
54 INT184523 Ptger2 Positive_regulation of VEGFA 1 0.02 0.56 0.08 95.20
55 INT137386 Ghrl Regulation of Gene_expression of Pigm 1 0.00 0.36 0.3 95.16
56 INT137385 Ghrl Negative_regulation of Gene_expression of Pigm 1 0.01 0.36 0.3 95.16
57 INT116592 CPOX Regulation of PTGER2 1 0.02 0.45 0.28 95.12
58 INT116593 CPOX Regulation of IL6 1 0.10 0.45 0.28 95.12
59 INT107029 Cpox Regulation of Pag1 1 0.01 1.24 1.15 94.88
60 INT96402 Binding of PTGS2 and TBXAS1 1 0.02 0.32 0.26 94.48
61 INT96401 Binding of PTGER1 and PTGS2 1 0.00 0.32 0.26 94.48
62 INT175398 Binding of ERBB2 and VEGFA 2 0.16 1.34 0.13 93.52
63 INT175401 Binding of EGFR and VEGFA 2 0.13 1.49 0.13 93.52
64 INT106527 Akt1 Positive_regulation of Jun 1 0.05 0.53 0.74 93.36
65 INT229041 Gene_expression of IL32 Negative_regulation of Gene_expression of PTGER2 1 0.01 1.17 0.38 93.28
66 INT99601 ZNF398 Negative_regulation of Transcription of MMP2 1 0.10 0.41 0.3 92.16
67 INT99600 ZNF398 Negative_regulation of Transcription of NR4A2 1 0.10 0.41 0.3 92.16
68 INT207338 Negative_regulation of CPOX Negative_regulation of ABCA1 1 0.11 0 0.16 92.08
69 INT107030 Cpox Regulation of Cpox Regulation of Pag1 1 0.01 0.62 0.57 92.04
70 INT116591 CASP1 Positive_regulation of PTGER2 1 0.01 0.46 0.28 92.00
71 INT187523 IRF6 Positive_regulation of Gene_expression of Cpox 1 0.00 1.38 0.31 91.88
72 INT207354 TBXA2R Regulation of Gene_expression of CYP27A1 1 0.01 0 0.17 91.72
73 INT207350 TBXA2R Regulation of Gene_expression of ABCA1 1 0.10 0 0.17 91.72
74 INT207349 TBXA2R Regulation of CYP27A1 1 0.01 0 0.16 91.72
75 INT207333 TBXA2R Negative_regulation of ZNF398 Regulation of CYP27A1 1 0.00 0 0.16 91.72
76 INT87294 SERPINA3 Negative_regulation of PTGS2 1 0.25 0.6 0.58 91.44
77 INT116595 CASP1 Positive_regulation of IL6 1 0.07 0.46 0.28 91.28
78 INT285077 CCL16 Positive_regulation of ITK 1 0.05 1.95 0.31 90.80
79 INT203171 PTGER2 Negative_regulation of ALOX5 1 0.01 0.89 0.77 90.64
80 INT137020 Il6 Positive_regulation of Pscs 1 0.07 0.43 0.34 90.48
81 INT137015 Il6 Positive_regulation of Gene_expression of Pscs 1 0.07 0.43 0.34 90.48
82 INT137018 Tgfb1 Positive_regulation of Pscs 1 0.01 0.43 0.34 90.48
83 INT137013 Tgfb1 Positive_regulation of Gene_expression of Pscs 1 0.01 0.43 0.34 90.48
84 INT99599 ZNF398 Negative_regulation of NR4A2 1 0.05 0.41 0.3 90.32
85 INT157141 Cpox Positive_regulation of Gene_expression of Camk2a 1 0.19 0.13 0.58 90.16
86 INT99602 ZNF398 Negative_regulation of MMP2 1 0.14 0.85 0.63 89.92
87 INT114066 Agtr2 Regulation of Gene_expression of Cpox 1 0.08 0.62 0.27 89.80
88 INT203168 PTGER2 Negative_regulation of Gene_expression of ALOX5AP 1 0.03 2.4 1.18 89.76
89 INT302161 AKT1 Negative_regulation of CASP9 1 0.03 0.87 0.11 89.76
90 INT203162 PTGER2 Regulation of Gene_expression of ALOX5AP 1 0.04 1.47 0.94 89.76
91 INT93581 Hgf Positive_regulation of Hgf Positive_regulation of Cpox 1 0.14 2.21 0.29 89.68
92 INT93580 Hgf Positive_regulation of Cpox 1 0.19 2.2 0.29 89.68
93 INT93579 Positive_regulation of Hgf Positive_regulation of Cpox 1 0.14 1.1 0.14 89.68
94 INT106526 jb Negative_regulation of Phosphorylation of Jun 1 0.02 0.14 0.19 89.52
95 INT181752 Binding of CPOX and ESR1 1 0.02 0.89 0.14 89.32
96 INT81991 Bmpr2 Positive_regulation of Gene_expression of ODF1 1 0.03 1.59 0.41 88.88
97 INT99603 ZNF398 Regulation of Transcription of MMP2 1 0.15 0.44 0.33 88.84
98 INT334590 IRF6 Positive_regulation of Localization of Ptger2 1 0.00 0 0.15 88.80
99 INT217271 Cpox Regulation of Gene_expression of Ptges 1 0.01 0.14 0.08 88.56
100 INT114068 Agtr2 Regulation of Gene_expression of Insr 1 0.15 0.95 0.79 88.24
101 INT149178 IL4 Negative_regulation of Positive_regulation of TGFB2 1 0.15 0.29 0.1 87.92
102 INT132318 Ghrl Positive_regulation of Localization of GH1 5 0.32 4.49 0.84 87.68
103 INT352961 Ghrl Positive_regulation of Localization of GHSR 1 0.18 1.19 0.21 87.68
104 INT105848 Il1b Positive_regulation of Gene_expression of Cpox 1 0.12 0.41 0.59 87.64
105 INT203167 Gene_expression of PTGER2 Positive_regulation of Gene_expression of ALOX5AP 1 0.03 0.67 0.38 87.44
106 INT149177 IL4 Negative_regulation of Positive_regulation of TNF 1 0.16 0.28 0.1 87.12
107 INT62176 Binding of PTGS2 and Ptgs1 2 0.00 0.69 0.79 86.72
108 INT207357 TBXA2R Positive_regulation of CYP27A1 1 0.01 0 0.16 86.64
109 INT74937 IL1B Positive_regulation of CPOX 5 0.18 1.13 1.55 86.16
110 INT116467 Vegfa Positive_regulation of Akt1 1 0.33 1.41 0.21 86.04
111 INT116466 Vegfa Positive_regulation of Amfr 1 0.07 1.41 0.21 86.04
112 INT209581 Twist1 Positive_regulation of Gene_expression of VEGFA 6 0.06 7.86 0.16 85.92
113 INT152748 Negative_regulation of Cpox Negative_regulation of Localization of Tnf 1 0.17 0.98 0.21 85.52
114 INT285070 CCL16 Positive_regulation of Gene_expression of CYP19A1 1 0.02 0.69 0.09 85.44
115 INT149983 Binding of Cpox and Nos2 1 0.30 0.54 0.69 84.96
116 INT152747 Negative_regulation of Abmm Positive_regulation of Tnf 1 0.01 0.64 0.2 84.88
117 INT152746 Abmm Positive_regulation of Tnf 1 0.01 0.64 0.2 84.88
118 INT203164 PTGER2 Regulation of ALOX5 1 0.00 0.9 0.78 84.64
119 INT116469 VEGFA Positive_regulation of Amfr 1 0.01 1.39 0.21 84.60
120 INT116468 VEGFA Positive_regulation of Akt1 1 0.04 1.39 0.21 84.60
121 INT302169 PTGER2 Positive_regulation of DYNC1LI1 1 0.02 1.51 0.25 84.56
122 INT141911 Arih2 Regulation of Positive_regulation of Cpox 1 0.01 1.19 0.76 84.56
123 INT141910 Arih2 Regulation of Cpox 1 0.01 1.19 0.76 84.56
124 INT137023 Gene_expression of SMAD2 Negative_regulation of Gene_expression of Acta2 1 0.00 0.43 0.29 84.36
125 INT301921 UCK2 Regulation of Gene_expression of FGF2 1 0.01 1.22 0.08 84.24
126 INT108879 Negative_regulation of PTGS2 Positive_regulation of Protein_catabolism of Nfkbia 1 0.00 0.43 0.31 84.12
127 INT295720 PTGER2 Regulation of MMP9 1 0.01 0.53 0.7 83.72
128 INT279415 Gene_expression of CPOX Positive_regulation of VEGFC 1 0.04 2.23 0.07 83.36
129 INT99597 Negative_regulation of CPOX Regulation of Negative_regulation of ZNF398 1 0.02 0.44 0.33 83.00
130 INT107703 PPARG Regulation of Gene_expression of CPOX 1 0.16 0.15 0.41 82.96
131 INT124477 MAP2K1 Positive_regulation of Positive_regulation of MAPK1 1 0.12 1.35 0.65 82.36
132 INT124475 MAP2K1 Positive_regulation of Positive_regulation of CPOX 1 0.04 0.68 0.33 82.36
133 INT279420 CPOX Positive_regulation of VEGFC 1 0.04 2.23 0.07 82.32
134 INT312104 Binding of ALOX5 and PTGES 1 0.13 0.14 0.04 82.32
135 INT258173 Negative_regulation of Cpox Negative_regulation of Gene_expression of Gtf3a 1 0.00 1.44 0.33 81.84
136 INT137033 Tgfb1 Positive_regulation of Gene_expression of Col1a1 1 0.01 0.42 0.28 81.72
137 INT137021 Positive_regulation of Pscs Positive_regulation of Gene_expression of Acta2 1 0.00 0.42 0.28 81.72
138 INT137014 Positive_regulation of Pscs Positive_regulation of Gene_expression of Col1a1 1 0.01 0.42 0.28 81.72
139 INT137012 Pscs Positive_regulation of Gene_expression of Col1a1 1 0.01 0.42 0.28 81.72
140 INT231638 HR Positive_regulation of Gene_expression of PTGER2 1 0.00 0 0.08 81.60
141 INT347291 Binding of AKT1 and CCL16 1 0.06 0.99 0.04 81.52
142 INT347299 Binding of AKT1 and ITK 1 0.04 0.99 0.04 81.52
143 INT302156 AKT1 Positive_regulation of E2F2 1 0.02 0.88 0.13 81.28
144 INT331925 Ptger2 Positive_regulation of Actvty1 1 0.01 0.77 0.38 81.28
145 INT285076 CCL16 Positive_regulation of Gene_expression of ITK 1 0.05 1.8 0.14 81.12
146 INT114069 Negative_regulation of Agtr2 Positive_regulation of Ptgs2 1 0.08 0.49 0.26 81.00
147 INT331927 Ptger2 Positive_regulation of Arg1 1 0.06 1.8 0.42 80.56
148 INT302287 Twist1 Positive_regulation of Positive_regulation of PTGER2 1 0.03 1.16 0.1 80.20
149 INT302288 Twist1 Positive_regulation of PTGER2 1 0.03 1.16 0.1 80.20
150 INT312119 ELANE Positive_regulation of Gene_expression of PTGES 1 0.18 0.74 0.33 79.64
151 INT108881 ZNF236 Regulation of Transcription of Nfkbia 1 0.00 0.36 0.26 79.44
152 INT99598 ZNF398 Negative_regulation of Gene_expression of MMP2 1 0.10 0.44 0.33 79.24
153 INT107706 PPARA Positive_regulation of Gene_expression of CPOX 1 0.18 0.14 0.4 79.04
154 INT295711 MMP9 Positive_regulation of Localization of VEGFA 1 0.06 0.29 0.74 78.40
155 INT117639 Serpini1 Negative_regulation of Cpox 1 0.00 0.64 0.72 78.32
156 INT347300 Binding of ITK and CCL16 1 0.02 0.97 0.04 78.00
157 INT98629 VEGFA Positive_regulation of Gene_expression of EGR1 1 0.52 0.42 0.61 77.56
158 INT98628 VEGFA Positive_regulation of Transcription of EGR1 1 0.52 0.42 0.61 77.56
159 INT203176 PTGER2 Regulation of Gene_expression of Lts1 1 0.00 0.37 0.23 77.20
160 INT323077 CPOX Negative_regulation of Gene_expression of Ptger2 1 0.00 1.57 1.05 77.12
161 INT313648 ISYNA1 Regulation of GOPC 1 0.02 0.08 0.2 76.72
162 INT121633 PTGER1 Positive_regulation of PDGFD 1 0.01 0.67 0.19 76.72
163 INT102553 HGF Positive_regulation of Phosphorylation of MAPK1 1 0.40 0.49 0.48 76.64
164 INT108878 ZNF236 Regulation of Protein_catabolism of Nfkbia 1 0.00 0.38 0.26 76.52
165 INT108880 ZNF236 Regulation of Gene_expression of Nfkbia 1 0.00 0.38 0.26 76.52
166 INT108877 ZNF236 Regulation of Phosphorylation of Nfkbia 1 0.00 0.38 0.26 76.52
167 INT313650 Binding of C8A and TRGC1 1 0.01 0.49 0.5 76.40
168 INT313655 ISYNA1 Regulation of COX18 1 0.01 0.08 0.2 76.32
169 INT121632 PTGER1 Positive_regulation of TGM1 1 0.00 0.67 0.19 76.08
170 INT231631 NUCB1 Positive_regulation of Gene_expression of PTGER2 1 0.05 0 0.07 76.00
171 INT104736 Ace Positive_regulation of Ren1 1 0.35 0 0.04 75.64
172 INT197111 Binding of IL1B and MCF2 1 0.02 2.12 1.4 75.44
173 INT197115 Binding of MCF2 and RETNLB 1 0.00 1.06 0.7 75.44
174 INT116594 Negative_regulation of PTGS2 Negative_regulation of Gene_expression of IL6 1 0.22 0.45 0.31 75.08
175 INT114029 Binding of ALB and Mmp3 1 0.01 0.31 0.55 75.00
176 INT114028 Negative_regulation of Binding of ALB and Mmp3 1 0.01 0.31 0.55 75.00
177 INT110315 Negative_regulation of ALOX5 Negative_regulation of Gene_expression of TNF 1 0.47 0.74 0.85 75.00
178 INT113113 COX5A Regulation of Gene_expression of MRXS5 1 0.10 0.9 0.45 75.00
179 INT107392 PTGS2 Positive_regulation of PTGS1 2 0.31 1.01 0.26 75.00
180 INT98631 Negative_regulation of VEGFA Positive_regulation of EGR1 1 0.44 0.18 0.24 73.32
181 INT131819 Binding of Cpox and Nfkb1 1 0.15 0.44 0.46 73.28
182 INT102552 HGF Positive_regulation of MAPK3 1 0.38 0.47 0.47 72.92
183 INT102555 HGF Positive_regulation of MAPK1 1 0.38 0.47 0.47 72.92
184 INT98630 VEGFA Positive_regulation of EGR1 1 0.52 0.18 0.24 72.92
185 INT126887 Protein_catabolism of SP4 Negative_regulation of Gene_expression of VEGFA 1 0.15 0.49 0.26 72.60
186 INT62164 Il1b Positive_regulation of PTGS2 1 0.00 0.49 0.47 72.40
187 INT62163 Il1b Positive_regulation of Positive_regulation of PTGS2 1 0.00 0.49 0.47 72.40
188 INT126886 Protein_catabolism of SP1 Negative_regulation of Gene_expression of VEGFA 1 0.03 0.49 0.26 72.28
189 INT105338 Prkaca Positive_regulation of AKT1 1 0.04 0.93 0.11 72.16
190 INT86430 IL6 Positive_regulation of Gene_expression of HP 1 0.15 3.61 0.83 71.76
191 INT254205 Binding of Myd88 and Tlr4 12 0.19 3.17 1.54 71.60
192 INT102554 HGF Positive_regulation of Phosphorylation of RPS6KA1 1 0.21 0.93 0.94 71.48
193 INT102556 HGF Positive_regulation of Phosphorylation of ELK1 1 0.10 0.46 0.47 71.48
194 INT107700 Positive_regulation of DCSTAMP Positive_regulation of CPOX 1 0.04 0.14 0.38 70.88
195 INT107697 DCSTAMP Positive_regulation of CPOX 1 0.06 0.14 0.38 70.88
196 INT251892 Binding of Plau and Naf1 1 0.07 0.06 0.04 70.72
197 INT314265 PTGER2 Positive_regulation of Gene_expression of PTGES2 1 0.00 0.19 0.08 70.12
198 INT137011 Il6 Positive_regulation of Acta2 1 0.00 0.34 0.22 70.00
199 INT149628 Il1b Regulation of Gene_expression of Ptgs2 1 0.30 0.84 0.84 68.36
200 INT137032 Il6 Positive_regulation of Localization of Tgfb1 1 0.04 0.51 0.27 68.00

Single Events

The table below shows the top 200 pain related interactions that have been reported for COX-2 inhibitor. They are ordered first by their pain relevance and then by number of times they were reported in COX-2 inhibitor. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT50058 Negative_regulation of Cpox 907 0.58 426.28 428.29 100.00
2 INT49750 Negative_regulation of CPOX 735 0.58 360.06 274.19 100.00
3 INT34869 Negative_regulation of PTGS2 778 0.59 366.76 319.85 100.00
4 INT50670 Gene_expression of CPOX 763 0.76 442.13 195.02 100.00
5 INT49441 Negative_regulation of Cpox 494 0.59 303.22 177.46 100.00
6 INT51921 Gene_expression of Cpox 501 0.73 229.81 157.81 100.00
7 INT6580 Negative_regulation of Ptgs1 929 0.59 381.53 376.26 100.00
8 INT49439 Gene_expression of Cpox 508 0.73 326.97 130.17 100.00
9 INT55944 Positive_regulation of Cpox 214 0.57 105.14 81.4 100.00
10 INT35975 Regulation of Cpox 109 0.39 57.88 49.69 100.00
11 INT50672 Positive_regulation of CPOX 205 0.44 125.93 60.06 100.00
12 INT50673 Positive_regulation of Gene_expression of CPOX 156 0.54 97.31 37.03 100.00
13 INT8413 Gene_expression of Ptgs1 248 0.78 110.17 108.58 100.00
14 INT64171 Regulation of CPOX 109 0.36 55.36 32.96 100.00
15 INT9053 Negative_regulation of ALOX5 97 0.58 40.34 29.94 100.00
16 INT28312 Gene_expression of ABCA1 85 0.72 37.69 9.27 100.00
17 INT19132 Gene_expression of CYP27A1 83 0.75 34.31 10.17 100.00
18 INT81194 Binding of CPOX 40 0.29 23.7 18.95 100.00
19 INT55335 Binding of Cpox 49 0.34 15.48 18.46 100.00
20 INT75918 Negative_regulation of Negative_regulation of Cpox 19 0.23 10.05 14.4 100.00
21 INT114849 Negative_regulation of Olr522 4 0.07 7.1 1.47 100.00
22 INT78990 Regulation of Cpox 72 0.57 35.22 18.16 100.00
23 INT64175 Negative_regulation of Gene_expression of CPOX 66 0.38 39.64 23.07 100.00
24 INT69876 Negative_regulation of Nfkb1 147 0.58 89.81 55.5 100.00
25 INT64170 Gene_expression of GLI2 31 0.46 14.96 3.99 100.00
26 INT76427 Regulation of Negative_regulation of Cpox 17 0.31 6.75 7.93 100.00
27 INT62813 Negative_regulation of ZNF398 12 0.09 6.2 4.49 100.00
28 INT89603 Regulation of Negative_regulation of Cpox 11 0.30 10.59 6.28 100.00
29 INT131817 Negative_regulation of Asmt 1 0.02 1.59 1.85 100.00
30 INT53083 Gene_expression of Ptgs2 153 0.78 90.04 50.39 100.00
31 INT74272 Localization of CPOX 39 0.63 25.12 10.53 100.00
32 INT83611 Negative_regulation of Gene_expression of Cpox 55 0.29 31.09 11.5 100.00
33 INT35486 Regulation of PTGER2 39 0.36 19.03 6.75 100.00
34 INT22275 Negative_regulation of TBXA2R 25 0.54 8.67 7.34 100.00
35 INT51922 Localization of Cpox 24 0.68 12.05 8.59 100.00
36 INT12992 Negative_regulation of Gene_expression of Ptgs1 33 0.42 20.47 11.77 100.00
37 INT352194 Negative_regulation of Gm10404 1 0.03 4.3 4.82 100.00
38 INT69966 Positive_regulation of Negative_regulation of CPOX 11 0.45 6.18 4.64 100.00
39 INT11380 Negative_regulation of IL1B 215 0.59 125.62 72.35 100.00
40 INT75768 Transcription of Cpox 37 0.27 19.41 9.79 100.00
41 INT11554 Negative_regulation of CSF2 129 0.59 108.55 29.44 100.00
42 INT139402 Negative_regulation of Tnrc6a 1 0.00 2.22 1.8 100.00
43 INT99129 Negative_regulation of LTB 5 0.57 0.7 2.84 100.00
44 INT77427 Regulation of Negative_regulation of CPOX 17 0.26 10.03 6.15 100.00
45 INT77429 Negative_regulation of Negative_regulation of CPOX 9 0.34 5.09 4.64 100.00
46 INT154094 Negative_regulation of Eae1 25 0.18 30.42 7.89 100.00
47 INT352195 Negative_regulation of Igkv12-66 1 0.01 2.98 2.89 100.00
48 INT121036 Positive_regulation of Transcription of Cpox 12 0.21 6.34 2.04 100.00
49 INT101517 Negative_regulation of PPARA 168 0.57 112.24 21.41 100.00
50 INT64176 Transcription of CPOX 35 0.41 15.1 5.5 100.00
51 INT103094 Binding of PPARA 308 0.47 177.26 34.75 100.00
52 INT105336 Regulation of AKT1 52 0.56 32.53 4.89 100.00
53 INT103623 Negative_regulation of Serpini1 2 0.02 0.15 0.68 100.00
54 INT94934 Negative_regulation of COX1 3 0.57 3.27 1.75 100.00
55 INT21487 Negative_regulation of HCC 18 0.49 29.81 1.88 100.00
56 INT88349 Negative_regulation of Bp299 1 0.00 0.18 0.24 100.00
57 INT102658 Negative_regulation of Gene_expression of CSF2 42 0.50 38.63 8.32 100.00
58 INT169193 Negative_regulation of FOLR4 1 0.01 1.64 0.45 100.00
59 INT65295 Negative_regulation of Bdkrb2 9 0.37 6.36 6.49 100.00
60 INT123549 Negative_regulation of TNRC6A 1 0.00 0.44 0.54 100.00
61 INT94896 Regulation of TEP1 12 0.39 8.04 0.69 100.00
62 INT114061 Regulation of Gene_expression of Insr 4 0.27 2.03 1.56 100.00
63 INT120340 Negative_regulation of Abt1 2 0.10 1.27 1.45 100.00
64 INT9210 Regulation of IL6 166 0.62 125.61 49.95 100.00
65 INT122584 Negative_regulation of Gene_expression of PPARA 56 0.58 37.61 9.76 100.00
66 INT24080 Negative_regulation of Mtor 64 0.37 41.56 5.19 100.00
67 INT62684 Negative_regulation of TP53 66 0.58 66.09 4.62 100.00
68 INT117785 Regulation of Gene_expression of EGF 7 0.44 4.22 2.87 100.00
69 INT131608 Negative_regulation of Negative_regulation of Tbxa2r 1 0.33 0 0.42 100.00
70 INT98203 Negative_regulation of KRAS 5 0.42 2.38 0.34 100.00
71 INT92215 Negative_regulation of Utp6 1 0.05 0.41 0.14 100.00
72 INT142657 Regulation of Gene_expression of Col3a1 2 0.15 1.6 0.14 100.00
73 INT111684 Binding of Hgf 2 0.34 0.42 0.12 100.00
74 INT87212 Negative_regulation of Positive_regulation of Nfkb1 74 0.57 38.21 28.31 99.98
75 INT77925 Negative_regulation of TEP1 21 0.53 15.23 2.62 99.98
76 INT34488 Negative_regulation of MMP2 85 0.59 41.98 21.72 99.98
77 INT91462 Positive_regulation of Phosphorylation of MAPK1 99 0.67 40.28 18.99 99.98
78 INT132495 Negative_regulation of Gene_expression of Ppard 4 0.44 2.64 1.28 99.98
79 INT96580 Negative_regulation of Protein_catabolism of MMP2 2 0.55 0.6 0.51 99.98
80 INT157138 Negative_regulation of Gene_expression of Camk2a 1 0.37 0.07 0.26 99.98
81 INT26501 Positive_regulation of Gene_expression of MMP2 51 0.67 39 15.16 99.96
82 INT93844 Gene_expression of Ptgir 19 0.77 12.12 7.66 99.92
83 INT65262 Gene_expression of Lox 47 0.74 36.59 5.65 99.92
84 INT173610 Negative_regulation of Gene_expression of Ptgir 1 0.03 2.13 1.68 99.92
85 INT205494 Negative_regulation of Negative_regulation of ALOX5 2 0.32 1.2 0.54 99.92
86 INT145459 Negative_regulation of Transcription of Osm 1 0.06 1.23 1.38 99.92
87 INT145458 Transcription of Osm 1 0.08 1.22 1.37 99.92
88 INT1764 Negative_regulation of Gene_expression of PTGER2 81 0.34 34.74 19.45 99.90
89 INT8097 Gene_expression of EGF 122 0.77 75.94 28.47 99.90
90 INT50143 Negative_regulation of Gene_expression of Ptgds 10 0.48 5.82 3.54 99.90
91 INT131816 Negative_regulation of Pars2 1 0.19 1.05 1.31 99.88
92 INT80222 Negative_regulation of Bcl2 82 0.58 69.16 13.18 99.84
93 INT68684 Gene_expression of VEGFA 2371 0.78 1742.52 259.2 99.84
94 INT99688 Negative_regulation of Gene_expression of VEGFA 274 0.58 201.8 31.1 99.84
95 INT52264 Gene_expression of IK 180 0.77 90.87 51.87 99.84
96 INT81777 Negative_regulation of Gene_expression of IK 22 0.08 11.55 8.09 99.84
97 INT93715 Negative_regulation of MMP9 69 0.55 36.05 11.73 99.84
98 INT47752 Regulation of Fam166a 6 0.00 1.93 1.82 99.84
99 INT126893 Regulation of SP4 1 0.60 0.46 0.22 99.84
100 INT126899 Regulation of SP1 5 0.43 2.53 0.57 99.84
101 INT11587 Gene_expression of CSF2 645 0.78 544.38 93.89 99.84
102 INT5501 Regulation of Oprd1 283 0.62 55.1 249.9 99.84
103 INT284521 Negative_regulation of CX3CL1 11 0.27 13.86 1.87 99.84
104 INT113282 Negative_regulation of TNFRSF11B 17 0.57 13.71 4.17 99.84
105 INT66585 Gene_expression of IER3 13 0.63 7.39 3.48 99.84
106 INT82542 Negative_regulation of Gene_expression of IER3 3 0.13 0.16 0.65 99.84
107 INT142836 Positive_regulation of Tpi1 1 0.08 0 0.4 99.84
108 INT39565 Gene_expression of Ptger2 424 0.75 229.28 72.68 99.82
109 INT27096 Positive_regulation of Nfkb1 325 0.70 195.11 109.06 99.82
110 INT9660 Regulation of TNF 363 0.62 312.94 139.99 99.82
111 INT3950 Gene_expression of Ptger2 293 0.77 122.28 62.42 99.82
112 INT103399 Positive_regulation of Positive_regulation of Pparg 11 0.66 7 7.36 99.82
113 INT2389 Regulation of PTGS1 86 0.61 31.23 28.95 99.80
114 INT18670 Negative_regulation of ABCA1 16 0.54 5.8 3.39 99.80
115 INT53184 Negative_regulation of CYP27A1 46 0.57 16.04 5.28 99.80
116 INT110023 Negative_regulation of Mapk14 127 0.59 84.27 45.42 99.80
117 INT11346 Binding of Mtx1 39 0.41 24.88 21.21 99.80
118 INT61114 Gene_expression of Ppard 23 0.75 14.98 6.62 99.80
119 INT98635 Negative_regulation of Gene_expression of EGR1 5 0.58 2.2 1.42 99.80
120 INT87436 Regulation of Fgf2 6 0.45 3.95 2.03 99.80
121 INT54571 Positive_regulation of NFKB1 263 0.70 138.99 87.32 99.78
122 INT71786 Phosphorylation of MAPK1 256 0.82 110.09 46.17 99.78
123 INT20462 Binding of ESR1 210 0.44 102.7 26.34 99.78
124 INT1760 Gene_expression of PTGER2 524 0.57 226.94 96.4 99.76
125 INT89395 Negative_regulation of AKT1 127 0.58 70.27 12.54 99.76
126 INT102814 Negative_regulation of CASP3 46 0.43 28.54 6.94 99.76
127 INT108589 Negative_regulation of Gene_expression of CASP3 13 0.57 10.52 2.14 99.76
128 INT94051 Positive_regulation of Arg1 41 0.60 36.22 13.72 99.74
129 INT3765 Positive_regulation of Actvty1 8 0.06 23.53 7.37 99.74
130 INT127062 Positive_regulation of Gene_expression of LTB4R 18 0.34 15.9 5.64 99.72
131 INT26795 Gene_expression of Mtpn 44 0.62 27.66 8.62 99.72
132 INT65960 Gene_expression of BCL2 352 0.78 312.03 30.73 99.70
133 INT80223 Positive_regulation of Hmox1 128 0.68 77.71 17.64 99.70
134 INT660 Negative_regulation of REN 194 0.59 82.06 29.46 99.70
135 INT71789 Positive_regulation of MAPK1 396 0.70 234.44 89.27 99.68
136 INT90202 Protein_catabolism of MMP2 15 0.94 7.47 5.41 99.68
137 INT67039 Positive_regulation of Cpox 144 0.65 98.4 33.77 99.66
138 INT15514 Negative_regulation of Crp 275 0.59 194.6 64.86 99.66
139 INT73599 Negative_regulation of Gene_expression of Cpox 47 0.55 19.89 17.26 99.64
140 INT1951 Positive_regulation of Tlr4 345 0.70 176.99 62.42 99.64
141 INT28420 Gene_expression of Ptgds 59 0.78 31.72 12.67 99.64
142 INT69289 Negative_regulation of Cftr 44 0.57 13.28 6.97 99.64
143 INT1761 Positive_regulation of PTGER2 135 0.49 90.17 26.26 99.62
144 INT17381 Gene_expression of Tbxa2r 146 0.78 65.01 34.15 99.62
145 INT77306 Negative_regulation of Gene_expression of Bcl2 46 0.58 38.05 7.71 99.62
146 INT44647 Positive_regulation of TBXA2R 14 0.57 6.95 1.64 99.62
147 INT145328 Negative_regulation of Scrib 25 0.16 26.79 2.66 99.62
148 INT77307 Gene_expression of Bcl2 399 0.77 319.77 38 99.60
149 INT9196 Gene_expression of PTGS1 215 0.77 96.99 60.5 99.60
150 INT37896 Positive_regulation of Gene_expression of PTGS1 37 0.67 17.28 9.27 99.60
151 INT71594 Positive_regulation of Gene_expression of Camk2a 8 0.47 1.07 4.35 99.60
152 INT79194 Positive_regulation of Tnc 5 0.41 2.25 4.69 99.60
153 INT39564 Negative_regulation of Gene_expression of Ptger2 50 0.42 30.9 12.97 99.58
154 INT121823 Negative_regulation of Negative_regulation of Mpo 4 0.39 2.37 0.97 99.58
155 INT53949 Positive_regulation of Gene_expression of Cpox 82 0.65 38.12 25.93 99.56
156 INT26500 Gene_expression of MMP2 201 0.78 110.57 46.9 99.56
157 INT149243 Positive_regulation of Slc12a1 3 0.59 1.57 0.82 99.54
158 INT108348 Positive_regulation of Aqp2 10 0.68 4.94 0.82 99.54
159 INT76091 Positive_regulation of NOS3 48 0.61 18.4 7.92 99.52
160 INT74812 Negative_regulation of Positive_regulation of Cpox 17 0.34 10.1 9.94 99.52
161 INT94863 Gene_expression of Litaf 27 0.65 10.21 4.35 99.52
162 INT142184 Regulation of TXK 10 0.11 8.25 0.59 99.52
163 INT151126 Negative_regulation of Gene_expression of Litaf 6 0.32 2.48 1.21 99.52
164 INT375 Positive_regulation of REN 293 0.70 152.46 47.55 99.50
165 INT73021 Gene_expression of EGR1 43 0.77 24.65 9.18 99.50
166 INT73022 Positive_regulation of Gene_expression of EGR1 21 0.69 10.61 6.5 99.50
167 INT51685 Gene_expression of LTB4R 87 0.58 68.69 31.72 99.48
168 INT57691 Regulation of Gene_expression of Ptger2 23 0.40 17.08 4.61 99.48
169 INT53491 Negative_regulation of Jun 28 0.57 14.2 6.9 99.48
170 INT109265 Transcription of Th 18 0.68 4.5 8.21 99.48
171 INT126172 Negative_regulation of Pla2g4a 7 0.39 9.01 2.89 99.48
172 INT126173 Negative_regulation of Regulation of Pla2g4a 1 0.40 1.01 0.37 99.48
173 INT108588 Gene_expression of CASP3 126 0.78 84.49 16.2 99.46
174 INT98130 Positive_regulation of CASP8 79 0.67 65.29 10.08 99.44
175 INT39047 Gene_expression of PGF 34 0.78 17.48 6 99.44
176 INT157666 Positive_regulation of GOPC 335 0.60 120.19 42.75 99.44
177 INT71590 Gene_expression of Camk2a 17 0.78 2.3 8.63 99.44
178 INT184475 Protein_catabolism of Ptger2 5 0.30 1.85 0.57 99.44
179 INT295690 Negative_regulation of Regulation of MMP9 1 0.11 0.99 0.33 99.44
180 INT142907 Regulation of Localization of Fgf2 1 0.44 1.16 0.53 99.44
181 INT122195 Regulation of Localization of VEGFA 13 0.57 10.61 1.92 99.44
182 INT89282 Regulation of MMP9 39 0.60 25.45 10.34 99.44
183 INT37037 Positive_regulation of ANTXR2 6 0.50 5.75 1.56 99.44
184 INT114788 Negative_regulation of Positive_regulation of Kras 1 0.04 0.65 0.28 99.42
185 INT52692 Gene_expression of Ptgs2 160 0.78 85.06 55.73 99.40
186 INT134298 Gene_expression of Ptges2 96 0.54 56.52 17.19 99.40
187 INT10565 Gene_expression of MRXS5 94 0.53 37.35 19.08 99.40
188 INT149238 Positive_regulation of Gene_expression of Aqp2 5 0.66 3.07 0.73 99.40
189 INT149236 Positive_regulation of Gene_expression of Slc12a1 1 0.42 0.76 0.32 99.40
190 INT149240 Positive_regulation of Gene_expression of Slc34a3 1 0.07 0.75 0.32 99.40
191 INT52693 Positive_regulation of Gene_expression of Ptgs2 57 0.70 25.51 21.18 99.40
192 INT71787 Positive_regulation of MAPK3 37 0.67 17.5 17.88 99.38
193 INT108628 Regulation of MMP2 27 0.60 14.85 6.06 99.38
194 INT67614 Positive_regulation of PPARA 438 0.68 293.28 63.61 99.36
195 INT107334 Negative_regulation of Pklr 5 0.04 0.81 1.99 99.36
196 INT141656 Regulation of Eae1 22 0.39 32.62 8.12 99.32
197 INT154233 Negative_regulation of Lox 32 0.56 38.89 3.17 99.32
198 INT17961 Regulation of Pla2g4a 9 0.25 4.86 2.3 99.32
199 INT240127 Binding of Nppb 19 0.37 22.42 3.3 99.32
200 INT231653 Negative_regulation of Gene_expression of NUCB1 1 0.34 0 0.05 99.32
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