P:Chronic low back pain

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Pain Term
Category Disorder
Synonyms None
Pain Specific Yes
Documents 2323
Hot Single Events 104
Hot Interactions 5

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported for Chronic low back pain. They are ordered first by their pain relevance and then by number of times they were reported for Chronic low back pain. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT234609 Binding of CASP3 and IMMT 1 0.00 0.5 0.5 99.24
2 INT340117 Binding of Bdnf and Pain1 1 0.01 2.48 2.55 99.16
3 INT340118 Binding of Sugt1 and Pain1 1 0.00 3.53 3.44 87.84
4 INT346986 Binding of SHC3 and PAG1 1 0.35 1.02 1.12 86.04
5 INT250933 IL1B Positive_regulation of Gene_expression of BDNF 1 0.10 0.27 0.5 82.64
6 INT340113 Comt Regulation of Bdnf 1 0.21 0.74 0.82 54.52
7 INT308542 Binding of AIM1 and AIM2 1 0.12 0 0 50.00
8 INT73772 NR3C1 Regulation of Regulation of Crh 1 0.02 0.68 0.38 47.00
9 INT122163 Binding of TNF and TNFRSF1B 6 0.44 6.06 2.41 5.00
10 INT148704 Binding of TNF and TNFRSF1A 5 0.44 3.3 2.09 5.00
11 INT136273 NGF Regulation of Gene_expression of BDNF 2 0.41 1.14 1.78 5.00
12 INT250934 Binding of BDNF and NGF 3 0.39 0.62 1.34 5.00
13 INT121705 IL1B Positive_regulation of Gene_expression of MMP3 3 0.49 1.2 1.3 5.00
14 INT277832 Binding of TNFRSF1B and NPEPPS 1 0.01 1.1 0.88 5.00
15 INT277831 Binding of TNFRSF1A and NPEPPS 1 0.01 1.1 0.87 5.00
16 INT265566 Binding of PDE4D and PTPN5 1 0.03 0.81 0.85 5.00
17 INT340115 Comt Regulation of Localization of Dusp1 1 0.12 0.83 0.83 5.00
18 INT340114 Comt Regulation of Localization of Pain1 1 0.02 0.83 0.83 5.00
19 INT162241 Binding of COL7A1 and MMP13 2 0.03 0.86 0.73 5.00
20 INT250932 IL1B Regulation of Gene_expression of BDNF 1 0.06 0.24 0.69 5.00
21 INT340116 Dusp1 Regulation of Transcription of Oprm1 1 0.12 0.71 0.69 5.00
22 INT220155 IL1RN Regulation of IL1B 2 0.50 0.93 0.61 5.00
23 INT220243 IL1RN Negative_regulation of Gene_expression of DPEP1 1 0.20 0.22 0.19 5.00
24 INT220240 IL1RN Negative_regulation of Gene_expression of MOCS1 1 0.01 0 0.12 5.00
25 INT220237 IL1B Regulation of Gene_expression of LONP1 1 0.03 0 0.08 5.00
26 INT220248 IL1RN Regulation of Gene_expression of LONP1 1 0.04 0 0.08 5.00
27 INT220244 IL1B Regulation of Gene_expression of DPEP1 1 0.17 0 0.08 5.00
28 INT220241 IL1RN Regulation of Gene_expression of DPEP1 1 0.24 0 0.08 5.00
29 INT220238 IL1RN Regulation of Protein_catabolism of DPEP1 1 0.14 0 0.08 5.00
30 INT220247 IL1B Regulation of Protein_catabolism of DPEP1 1 0.10 0 0.08 5.00
31 INT220246 IL1B Positive_regulation of MMP7 1 0.11 0 0.04 5.00
32 INT220239 IL1B Positive_regulation of MMP13 1 0.23 0 0.04 5.00
33 INT311925 Binding of NRP2 and SEMA3A 1 0.26 0.06 0.04 5.00
34 INT173056 Binding of NRP2 and NRP1 2 0.24 0.61 0.04 5.00
35 INT311926 Binding of NRP1 and SEMA3A 1 0.26 0.48 0.04 5.00
36 INT220242 IL1B Positive_regulation of Gene_expression of MOCS1 1 0.01 0 0.04 5.00
37 INT184208 IL1B Negative_regulation of SOX9 1 0.32 0 0.03 5.00
38 INT220245 IL1RN Regulation of Protein_catabolism of COL2A1 1 0.09 0 0.03 5.00
39 INT220236 Positive_regulation of IL1RN Negative_regulation of Gene_expression of MOCS1 1 0.01 0 0.03 5.00
40 INT184209 IL1B Negative_regulation of Gene_expression of SOX6 1 0.46 0.05 0.03 5.00
41 INT311927 AASDH Positive_regulation of NRP2 1 0.02 0.1 0.03 5.00
42 INT184210 IL1B Negative_regulation of Gene_expression of COL1A2 1 0.04 0 0 5.00
43 INT311948 Binding of NRP1 and Plxna3 1 0.05 0.26 0 5.00
44 INT311947 Binding of SEMA3A and Plxna3 1 0.07 0.26 0 5.00
45 INT184211 GOPC Negative_regulation of Gene_expression of ADAMTS5 1 0.07 0 0 5.00

Single Events

The table below shows the top 200 pain related interactions that have been reported for Chronic low back pain. They are ordered first by their pain relevance and then by number of times they were reported in Chronic low back pain. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT1026 Binding of Lbp 207 0.48 150.96 119.16 100.00
2 INT57000 Localization of LBP 21 0.78 11.01 10.01 100.00
3 INT1027 Gene_expression of Lbp 132 0.77 106.7 54.16 100.00
4 INT9088 Negative_regulation of LBP 48 0.58 33.06 25.89 100.00
5 INT32624 Regulation of LBP 15 0.60 11.48 8.71 100.00
6 INT19759 Gene_expression of LBP 77 0.77 56.44 33.23 100.00
7 INT63553 Binding of PAG1 14 0.48 12.51 14.76 100.00
8 INT9664 Binding of LBP 127 0.48 94.9 63.42 100.00
9 INT81417 Gene_expression of PAG1 94 0.58 90.85 92.79 100.00
10 INT203739 Negative_regulation of NCF1 2 0.27 1.22 0.82 100.00
11 INT77855 Gene_expression of Pain1 55 0.75 67.42 54.1 100.00
12 INT92716 Negative_regulation of PAG1 6 0.51 5.82 6.32 100.00
13 INT174656 Binding of NCF1 5 0.37 6.46 1.65 100.00
14 INT99058 Regulation of PAG1 18 0.45 21.62 18.5 100.00
15 INT69951 Binding of Cgnz1 3 0.25 1.82 1.64 100.00
16 INT21167 Regulation of NCF1 3 0.15 0.75 1.24 100.00
17 INT286451 Gene_expression of AIM2 2 0.43 0.1 0.1 100.00
18 INT952 Negative_regulation of GHRH 57 0.56 25.3 10.34 99.84
19 INT168091 Gene_expression of STRAP 1 0.45 0.92 0.71 99.78
20 INT138594 Gene_expression of COP 10 0.57 1.33 0.98 99.72
21 INT14823 Gene_expression of MET 103 0.75 51.92 32.48 99.66
22 INT178828 Regulation of Pain1 12 0.14 16.1 15.64 99.66
23 INT15516 Gene_expression of Crp 711 0.77 615.33 173.09 99.48
24 INT5374 Gene_expression of Esr1 412 0.77 263.89 67.34 99.28
25 INT102639 Positive_regulation of VDR 31 0.69 18.05 2.38 99.18
26 INT188259 Regulation of IMMT 1 0.02 0.9 0.77 99.16
27 INT92669 Gene_expression of Bdnf 309 0.78 178.26 116.68 99.16
28 INT163479 Binding of Bdnf 36 0.48 25.77 14.83 99.16
29 INT39507 Positive_regulation of TXNRD1 37 0.68 12.47 14.25 99.08
30 INT103474 Regulation of Gene_expression of BDNF 40 0.60 12.14 9.65 99.00
31 INT234610 Protein_catabolism of IMMT 1 0.05 0.5 0.5 98.88
32 INT22454 Regulation of Crp 213 0.62 160.67 49.24 98.52
33 INT75999 Gene_expression of BDNF 344 0.78 114.19 83.12 98.48
34 INT38698 Positive_regulation of COP 9 0.59 2.05 4.48 98.34
35 INT58288 Positive_regulation of Gene_expression of Crp 83 0.61 82.23 23.7 98.24
36 INT20462 Binding of ESR1 210 0.44 102.7 26.34 98.22
37 INT88805 Protein_catabolism of CASP3 24 0.86 18.38 3.7 98.16
38 INT3361 Positive_regulation of Esr1 273 0.69 208.53 44.81 97.96
39 INT43997 Positive_regulation of Gene_expression of Esr1 57 0.51 36.66 5.51 97.96
40 INT221876 Gene_expression of AIM1 2 0.13 0.61 0.15 97.96
41 INT17237 Regulation of Esr1 74 0.43 49.09 17.25 97.68
42 INT38056 Localization of Crp 71 0.78 53.14 17.03 97.68
43 INT7439 Positive_regulation of CFP 52 0.67 19.97 17.87 97.68
44 INT2038 Localization of Esr1 104 0.79 40.12 13.27 97.68
45 INT123701 Negative_regulation of VDR 61 0.59 48.94 9.67 96.56
46 INT162666 Gene_expression of ST3 5 0.67 5.66 1.73 95.92
47 INT125384 Positive_regulation of Pain1 23 0.49 17.1 14.83 95.92
48 INT15610 Localization of GOPC 223 0.65 68.26 28.7 95.76
49 INT178754 Positive_regulation of Localization of GOPC 32 0.43 10.1 4.73 95.76
50 INT274527 Regulation of SYNM 3 0.20 2.68 2.7 95.76
51 INT66960 Negative_regulation of ACACA 4 0.57 1.21 3.59 95.60
52 INT4297 Negative_regulation of CFP 21 0.42 12.7 10.29 95.60
53 INT52980 Positive_regulation of Dlat 20 0.37 5.14 4.06 94.92
54 INT1878 Binding of HLA-B 440 0.48 321.16 127.36 94.88
55 INT95006 Regulation of Localization of Crp 3 0.60 0.82 0.73 94.12
56 INT69992 Negative_regulation of Hmox2 93 0.50 49.01 44.07 93.92
57 INT66532 Positive_regulation of Pnoc 46 0.70 14.99 41.39 93.76
58 INT240710 Positive_regulation of Regulation of Esr1 1 0.09 1.34 0.47 93.48
59 INT156148 Gene_expression of CTGF 16 0.78 9.98 2.87 93.40
60 INT33951 Regulation of TXNRD1 18 0.51 6.97 4.02 93.24
61 INT15515 Positive_regulation of Crp 700 0.70 604.24 150.15 93.16
62 INT16959 Positive_regulation of Binding of HLA-B 8 0.50 6.77 2.96 93.08
63 INT6483 Gene_expression of TNF 3152 0.78 2515.62 929.82 93.04
64 INT167070 Positive_regulation of Gene_expression of MCS 3 0.30 3.75 1.48 92.92
65 INT62509 Gene_expression of MCS 58 0.67 21.46 6.57 92.16
66 INT19396 Regulation of Rac1 66 0.53 37.41 30.01 91.76
67 INT65286 Binding of ARIH1 10 0.48 4.3 0.76 91.56
68 INT67890 Positive_regulation of Gene_expression of SGCG 26 0.67 9.91 6.41 91.48
69 INT218959 Negative_regulation of Protein_catabolism of ESR1 3 0.37 0.97 1.9 91.16
70 INT218955 Protein_catabolism of ESR1 9 0.92 3.95 3.74 91.16
71 INT156850 Binding of VDR 40 0.47 24.86 4.87 91.00
72 INT144689 Regulation of RCT 49 0.53 25.91 9.6 90.96
73 INT647 Gene_expression of SGCG 211 0.75 78.46 55.82 90.84
74 INT10142 Gene_expression of ANXA3 4 0.35 3.1 0.54 90.84
75 INT214577 Positive_regulation of Gene_expression of PCS 4 0.29 2.07 1.56 90.20
76 INT6481 Binding of TNF 624 0.48 510.2 214.82 90.16
77 INT90766 Gene_expression of PCS 93 0.77 40.48 14.51 89.96
78 INT196176 Gene_expression of SEMA3A 3 0.75 4.75 2.17 89.92
79 INT5972 Gene_expression of IL1B 948 0.78 510.91 263.97 89.52
80 INT83745 Gene_expression of SULT2A1 34 0.59 15.96 6.66 89.28
81 INT6849 Localization of IL1B 229 0.81 112.56 69.63 88.92
82 INT637 Positive_regulation of MRAP 23 0.67 21.13 9.97 88.44
83 INT1115 Regulation of Positive_regulation of MRAP 1 0.45 0.44 0.25 88.44
84 INT5235 Negative_regulation of TNF 924 0.59 772.91 331.98 88.40
85 INT10610 Negative_regulation of Plg 22 0.40 11.81 6.74 88.32
86 INT66531 Gene_expression of Pnoc 88 0.78 22.9 65.11 87.88
87 INT89854 Regulation of Nos2 49 0.61 42.58 24.1 87.48
88 INT66280 Gene_expression of Nos2 534 0.78 330.78 157.07 87.48
89 INT114162 Localization of Srms 5 0.60 2.22 4.14 87.36
90 INT39323 Negative_regulation of Serpinf2 2 0.47 0.59 0.62 87.04
91 INT316829 Negative_regulation of SYNM 4 0.54 3.31 3.32 86.80
92 INT16323 Gene_expression of pr 62 0.66 36.14 38.26 86.60
93 INT48902 Gene_expression of ACE2 22 0.78 17.91 3.24 86.48
94 INT291027 Binding of FAM84A 1 0.02 1.12 0.82 86.24
95 INT193663 Binding of Pain1 9 0.36 8.84 8.04 85.76
96 INT8346 Gene_expression of Qrfp 136 0.70 19.49 70.21 84.96
97 INT175482 Positive_regulation of Gene_expression of CALM1 12 0.44 3.47 6.54 83.88
98 INT9372 Negative_regulation of Lbp 86 0.58 46.54 41.71 83.36
99 INT33567 Gene_expression of CALM1 139 0.67 48.85 56.14 83.00
100 INT36338 Gene_expression of NRP2 29 0.67 6.47 2.4 81.36
101 INT77955 Negative_regulation of PCS 55 0.43 39.32 5.76 81.20
102 INT62374 Gene_expression of NGF 158 0.78 77.87 76.45 80.96
103 INT88130 Gene_expression of Spp1 13 0.74 12.96 3.07 80.84
104 INT144708 Regulation of Gene_expression of Spp1 1 0.04 0.32 0.08 80.84
105 INT141151 Regulation of PSMD1 16 0.40 8.19 5.86 79.72
106 INT4146 Binding of SHBG 49 0.47 31 4.71 79.60
107 INT545 Binding of GC 15 0.45 10.74 3.47 79.60
108 INT70615 Binding of TXNRD1 25 0.36 12.15 1.27 79.12
109 INT6852 Localization of TNF 883 0.81 705.95 270.84 78.64
110 INT90091 Gene_expression of GOPC 967 0.67 366.22 103.6 78.64
111 INT130428 Gene_expression of TSKU 11 0.65 8.02 4.81 78.08
112 INT210411 Localization of TSKU 1 0.57 1.17 0.8 78.08
113 INT3925 Negative_regulation of HLA-B 29 0.42 20.19 9.46 77.96
114 INT63373 Negative_regulation of Gene_expression of NGF 14 0.57 8.9 7.1 77.04
115 INT957 Positive_regulation of GHRH 136 0.70 36.84 40.52 76.32
116 INT49172 Regulation of Nos1 43 0.52 27.53 23.66 76.16
117 INT188258 Gene_expression of IMMT 3 0.07 0.72 0.57 75.80
118 INT78251 Positive_regulation of LBP 38 0.69 39.98 26.73 75.00
119 INT50058 Negative_regulation of Cpox 907 0.58 426.28 428.29 75.00
120 INT6580 Negative_regulation of Ptgs1 929 0.59 381.53 376.26 75.00
121 INT1029 Positive_regulation of Gene_expression of Lbp 17 0.50 11.03 5.18 75.00
122 INT163869 Regulation of Binding of Lbp 3 0.45 1.07 0.93 75.00
123 INT51055 Positive_regulation of TIMP1 103 0.69 50.07 19.86 74.88
124 INT168234 Negative_regulation of Col4a3bp 1 0.28 0.24 0.21 74.84
125 INT16868 Gene_expression of Il6 807 0.78 499.48 256.57 74.72
126 INT7205 Positive_regulation of HBG1 65 0.69 40.35 6.37 74.72
127 INT112655 Negative_regulation of PAM 3 0.57 0.97 1.39 73.52
128 INT168233 Positive_regulation of Transcription of Col2a1 2 0.45 1.78 0.99 73.04
129 INT443 Localization of POMC 1020 0.81 284.52 443.17 72.96
130 INT6128 Positive_regulation of Localization of POMC 256 0.70 68.77 121.64 72.96
131 INT128714 Transcription of Col2a1 6 0.52 2.13 1.24 72.64
132 INT170855 Negative_regulation of GOPC 188 0.38 70.92 15.41 72.52
133 INT12892 Negative_regulation of TIMP1 136 0.58 83.13 36.54 72.48
134 INT158469 Regulation of FECH 3 0.36 1.76 1.13 71.64
135 INT124853 Negative_regulation of Sugt1 5 0.03 2.29 1.25 71.52
136 INT120106 Negative_regulation of Mmp13 8 0.51 2.25 2.08 70.60
137 INT168231 Negative_regulation of Transcription of Nfib 1 0.42 0.23 0.2 70.60
138 INT1028 Positive_regulation of Lbp 102 0.69 67.86 46.05 70.32
139 INT88131 Negative_regulation of Spp1 3 0.56 0.7 0.21 69.16
140 INT156147 Positive_regulation of Gene_expression of CTGF 1 0.70 0.14 0.07 69.12
141 INT73431 Positive_regulation of Nos3 82 0.65 53.22 11.61 68.96
142 INT120108 Transcription of Mmp13 3 0.51 0.22 1.22 68.32
143 INT23435 Positive_regulation of NGF 54 0.70 32.41 30.11 67.80
144 INT48853 Positive_regulation of BDNF 82 0.69 43.92 27.99 67.80
145 INT168232 Positive_regulation of Transcription of Nfib 1 0.45 0.22 0.2 67.20
146 INT168235 Transcription of Nfib 1 0.52 0.22 0.2 67.20
147 INT80486 Gene_expression of FECH 13 0.54 10.42 4.8 66.32
148 INT1512 Binding of Prl 73 0.48 26.22 20.63 65.68
149 INT163061 Negative_regulation of IDH2 1 0.37 0.4 0.19 65.08
150 INT163062 Negative_regulation of Binding of IDH2 1 0.37 0.4 0.19 65.08
151 INT140063 Binding of IDH2 2 0.32 1.35 0.19 64.56
152 INT37296 Binding of Esr1 117 0.43 62.51 27.33 63.92
153 INT145937 Regulation of PCS 32 0.39 19.25 1.97 62.04
154 INT54834 Gene_expression of Col2a1 48 0.72 13.5 9.41 61.92
155 INT145306 Gene_expression of Sox9 5 0.54 2.47 0.8 61.92
156 INT73771 Regulation of EHHADH 1 0.44 0.94 0.58 60.84
157 INT32852 Negative_regulation of FECH 18 0.57 10.59 3.08 59.44
158 INT22024 Negative_regulation of HBG1 45 0.58 26 6.8 59.36
159 INT117204 Gene_expression of Tcm 39 0.58 10.58 4.88 58.72
160 INT158 Localization of Prl 2431 0.81 378.96 952.2 58.56
161 INT134346 Binding of PCS 51 0.37 22.27 5.67 58.48
162 INT48854 Positive_regulation of CALCB 4 0.46 2.4 3.06 58.36
163 INT11381 Positive_regulation of IL1B 330 0.70 209.31 100.9 58.24
164 INT36053 Positive_regulation of Positive_regulation of IL1B 22 0.70 11.41 6.84 58.24
165 INT2774 Binding of Crp 241 0.48 195.89 44.39 58.16
166 INT221764 Regulation of TSKU 1 0.14 0.51 0.24 56.64
167 INT103469 Positive_regulation of Gene_expression of BDNF 59 0.67 24.39 18.36 55.20
168 INT101120 Gene_expression of Comt 63 0.77 34.75 26.13 54.80
169 INT172197 Positive_regulation of Gene_expression of Comt 12 0.69 7.61 4.06 54.80
170 INT101121 Regulation of Comt 19 0.53 10.66 7.22 54.52
171 INT6482 Positive_regulation of Gene_expression of TNF 659 0.70 569.88 210 51.12
172 INT6473 Positive_regulation of Gene_expression of IL1B 204 0.70 117.23 50.86 51.12
173 INT1665 Positive_regulation of Pag1 270 0.68 186.63 229.87 50.00
174 INT2531 Positive_regulation of Cebpz 166 0.00 43.08 38.86 50.00
175 INT52179 Regulation of Lbp 39 0.61 25.4 18.32 50.00
176 INT85923 Positive_regulation of CREM 25 0.67 7.03 6.53 50.00
177 INT35765 Gene_expression of TXNRD1 47 0.56 9.16 4.43 50.00
178 INT38560 Positive_regulation of SEMG1 13 0.60 4.37 3.81 50.00
179 INT32208 Gene_expression of Lif 23 0.74 6.23 3.7 50.00
180 INT53567 Positive_regulation of FECH 14 0.45 11.03 1.82 50.00
181 INT102694 Localization of CREM 4 0.27 1.6 1.8 50.00
182 INT32552 Negative_regulation of Pnp 9 0.52 5.31 1.63 50.00
183 INT187362 Binding of PST 4 0.30 1.48 0.82 50.00
184 INT171879 Binding of ENOX1 9 0.03 3.37 0.77 50.00
185 INT119930 Negative_regulation of PST 3 0.34 0.26 0.22 50.00
186 INT134805 Positive_regulation of Positive_regulation of LBP 1 0.45 0.15 0 50.00
187 INT133412 Binding of SEMG1 3 0.32 0 0 50.00
188 INT156940 Regulation of Fer 1 0.23 0.08 0 50.00
189 INT308544 Positive_regulation of Gene_expression of AIM2 1 0.32 0 0 50.00
190 INT1273 Gene_expression of Avp 356 0.78 90.56 138.7 49.48
191 INT11141 Negative_regulation of Gene_expression of Avp 23 0.59 3.85 12.19 49.48
192 INT5503 Negative_regulation of Gene_expression of Crh 38 0.59 16.82 21.34 49.32
193 INT438 Gene_expression of Crh 376 0.78 159.11 169.17 49.00
194 INT11380 Negative_regulation of IL1B 215 0.59 125.62 72.35 49.00
195 INT311943 Negative_regulation of Gene_expression of SEMA3A 1 0.56 0.66 0.55 48.68
196 INT162 Regulation of Prl 794 0.62 165.01 322.24 48.64
197 INT195631 Binding of LSR 1 0.30 0 0 47.16
198 INT6477 Gene_expression of IL1RN 213 0.77 114.69 58.62 46.64
199 INT6474 Positive_regulation of Gene_expression of IL1RN 34 0.69 21.87 10.99 46.64
200 INT190833 Regulation of KCNA1 8 0.53 6.61 4.66 46.16
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