P:Cluster headache

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Pain Term
Category Disorder
Synonyms Headache Cluster, Migrainous Neuralgia
Pain Specific Yes
Documents 1869
Hot Single Events 200
Hot Interactions 2

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported for Cluster headache. They are ordered first by their pain relevance and then by number of times they were reported for Cluster headache. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT117404 Binding of Pnoc and OR4F4 1 0.00 0.46 0.86 99.92
2 INT27730 Binding of ALB and Shbg 2 0.01 0.44 0.5 98.24
3 INT111768 IL2 Positive_regulation of Localization of CRH 1 0.02 0 0 50.00
4 INT347962 Cpox Negative_regulation of Positive_regulation of Nos1 1 0.02 0.59 0.67 9.52
5 INT127128 Binding of CNR1 and CNR2 8 0.39 3.98 3.97 5.00
6 INT261831 Mapk1 Negative_regulation of Hspg2 1 0.00 1.26 1.42 5.00
7 INT261841 Mastl Positive_regulation of Trpa1 1 0.00 0.82 1.3 5.00
8 INT81127 Binding of Gabrd and Abat 3 0.25 0 0.96 5.00
9 INT261834 Itpr3 Positive_regulation of Prkca 2 0.01 0.33 0.78 5.00
10 INT261845 NGF Positive_regulation of Trpa1 1 0.04 0.73 0.71 5.00
11 INT261835 Camk2a Positive_regulation of Prkca 1 0.01 0.32 0.66 5.00
12 INT261832 Trpv1 Negative_regulation of Trpa1 1 0.10 0.58 0.64 5.00
13 INT261830 Hspg2 Negative_regulation of Trpa1 1 0.01 0.58 0.63 5.00
14 INT261828 Igf1 Regulation of Localization of Trpv2 1 0.02 1.04 0.58 5.00
15 INT290956 Binding of Slc3a1 and Lsd 1 0.03 0 0.51 5.00
16 INT261839 Binding of Car2 and Trpv1 1 0.03 0 0.45 5.00
17 INT290957 Lsd Positive_regulation of Gene_expression of Egr2 1 0.11 0.1 0.26 5.00
18 INT261842 Pla2g6 Positive_regulation of Trpm8 1 0.03 0 0.23 5.00
19 INT261833 Binding of Add3 and Trpv4 1 0.00 0.12 0 5.00
20 INT261838 Lyn Regulation of Trpv4 1 0.03 0.19 0 5.00
21 INT261840 Binding of Mtap7 and Trpv4 1 0.05 0.12 0 5.00
22 INT261843 Lyn Regulation of Regulation of Trpv4 1 0.03 0.19 0 5.00
23 INT261844 Lyn Positive_regulation of Lyn Regulation of Trpv4 1 0.01 0.19 0 5.00
24 INT261837 Binding of Aqp5 and Trpv4 1 0.05 0.17 0 5.00

Single Events

The table below shows the top 200 pain related interactions that have been reported for Cluster headache. They are ordered first by their pain relevance and then by number of times they were reported in Cluster headache. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT32581 Positive_regulation of C4B 9 0.45 11.17 9.05 100.00
2 INT32580 Gene_expression of C4B 24 0.75 17.95 7.75 100.00
3 INT32579 Binding of C4B 14 0.36 14.99 7.79 100.00
4 INT33466 Negative_regulation of C4B 14 0.43 9.06 4.64 100.00
5 INT182676 Transcription of C4B 1 0.31 4.82 3.66 100.00
6 INT158 Localization of Prl 2431 0.81 378.96 952.2 100.00
7 INT155 Positive_regulation of Prl 1233 0.70 317.93 457.82 100.00
8 INT17938 Binding of Cpe 28 0.48 11.17 13.62 100.00
9 INT720 Positive_regulation of POMC 807 0.70 237.37 353.83 100.00
10 INT46620 Positive_regulation of Positive_regulation of CSF1 1 0.12 2.9 2.94 100.00
11 INT157 Positive_regulation of Localization of Prl 790 0.70 104.54 374.78 100.00
12 INT164481 Binding of ADH4 1 0.36 1.04 1.59 100.00
13 INT216065 Localization of C4B 2 0.21 2.86 2.01 100.00
14 INT160553 Regulation of C4B 3 0.14 1.54 1.16 100.00
15 INT47690 Regulation of Bdnf 118 0.62 53.02 64.5 100.00
16 INT13897 Localization of Sst 65 0.81 14.91 32.24 100.00
17 INT20425 Localization of Cpe 23 0.81 5.18 9.14 100.00
18 INT29 Negative_regulation of Gast 74 0.59 24.85 24.96 100.00
19 INT53475 Gene_expression of MRI1 116 0.59 77.68 33.98 99.98
20 INT626 Localization of CALCA 289 0.81 125.39 221.15 99.96
21 INT956 Negative_regulation of PRL 94 0.59 42.72 23.01 99.96
22 INT162 Regulation of Prl 794 0.62 165.01 322.24 99.92
23 INT2540 Negative_regulation of Calca 538 0.59 172.11 384.38 99.92
24 INT1378 Negative_regulation of Regulation of Prl 27 0.43 9.16 9.9 99.92
25 INT132279 Binding of Hcrtr2 4 0.48 2.48 2.28 99.90
26 INT1893 Localization of Gh 1041 0.79 340.23 256.58 99.84
27 INT10274 Positive_regulation of Il1b 123 0.70 79.76 73.56 99.84
28 INT92791 Negative_regulation of Szt2 1 0.03 2.4 2.33 99.84
29 INT1648 Regulation of LHB 21 0.61 3.32 9.6 99.84
30 INT4808 Gene_expression of LTC4S 37 0.73 18.36 9.62 99.84
31 INT5822 Gene_expression of Ltb4r1 51 0.76 37.43 7.2 99.84
32 INT22003 Negative_regulation of Cpe 25 0.58 6.23 12.94 99.84
33 INT51017 Positive_regulation of Icam1 113 0.70 81.16 35.55 99.84
34 INT14009 Gene_expression of Sst 66 0.77 19.6 37.3 99.84
35 INT9729 Negative_regulation of LHB 14 0.42 1.86 4.63 99.84
36 INT27728 Negative_regulation of Gene_expression of LHB 2 0.04 1.59 0.53 99.84
37 INT27729 Negative_regulation of Regulation of LHB 1 0.02 0.44 0.53 99.84
38 INT4147 Gene_expression of LHB 8 0.49 3.94 2.88 99.84
39 INT151254 Binding of Hcrtr2 4 0.32 1.31 0.63 99.80
40 INT403 Localization of Trh 241 0.81 28.55 81.45 99.80
41 INT2649 Regulation of Calca 433 0.62 146.05 330.95 99.76
42 INT167836 Binding of CD200R1 1 0.36 0.84 0.88 99.76
43 INT167837 Binding of ADH7 1 0.36 0.84 0.88 99.76
44 INT5050 Regulation of Localization of Calca 149 0.62 41.25 148.57 99.76
45 INT27261 Regulation of Regulation of Calca 7 0.45 2.8 5.08 99.76
46 INT19941 Negative_regulation of Pf4 13 0.42 10.35 5.97 99.74
47 INT11208 Gene_expression of Cpe 23 0.78 2.42 11.09 99.72
48 INT7383 Localization of VIP 53 0.81 17.7 22.65 99.70
49 INT19539 Positive_regulation of Gene_expression of ADRA1D 10 0.67 9.4 2.9 99.70
50 INT3593 Gene_expression of ADRA1D 70 0.75 29.48 20.87 99.70
51 INT49103 Positive_regulation of Vcam1 71 0.69 59.52 19.85 99.66
52 INT1377 Positive_regulation of Trh 172 0.70 40.55 69.83 99.58
53 INT915 Positive_regulation of PRL 342 0.70 141.96 104.31 99.56
54 INT180497 Binding of MRI1 45 0.42 28.35 14.77 99.56
55 INT21350 Negative_regulation of Ltb4r1 11 0.33 6.77 2.88 99.56
56 INT19 Regulation of Gnrhr 131 0.62 36.4 55.66 99.56
57 INT10763 Localization of IL2 157 0.80 81.11 33.21 99.56
58 INT9012 Localization of Vip 283 0.81 31.71 106.16 99.52
59 INT2542 Localization of Calca 2008 0.81 518.3 1408.65 99.44
60 INT22597 Positive_regulation of TF 43 0.68 27.27 5.17 99.42
61 INT738 Regulation of POMC 459 0.62 111.19 243.74 99.36
62 INT25952 Negative_regulation of Regulation of POMC 4 0.36 0.76 1.96 99.36
63 INT70600 Positive_regulation of Exo1 9 0.39 4.36 2.05 99.36
64 INT135630 Negative_regulation of GON4L 1 0.51 1.67 1.82 99.28
65 INT94045 Regulation of Cacna1a 5 0.42 3.56 3.33 99.28
66 INT85571 Positive_regulation of Cacna1a 3 0.50 2.06 1.18 99.28
67 INT78317 Regulation of CACNA1A 8 0.62 7.68 3.08 99.24
68 INT2543 Positive_regulation of Calca 787 0.70 331.13 592.08 99.20
69 INT3401 Positive_regulation of Hp 22 0.69 16.33 7.97 99.20
70 INT3402 Positive_regulation of Positive_regulation of Hp 2 0.49 1.05 1 99.20
71 INT24581 Negative_regulation of LTC4S 2 0.40 2.05 0.91 99.20
72 INT17546 Negative_regulation of Ngf 135 0.59 60.28 77.19 99.18
73 INT4860 Positive_regulation of CALCA 148 0.00 73.35 97.61 99.16
74 INT17283 Positive_regulation of CSF1 37 0.59 24.16 10.01 99.16
75 INT59 Regulation of Adrb1 25 0.42 8.32 9.78 99.16
76 INT46621 Positive_regulation of Gene_expression of CSF1 17 0.47 10.53 3.59 99.16
77 INT46619 Gene_expression of CSF1 80 0.73 36.63 12.94 99.16
78 INT23463 Positive_regulation of Gene_expression of CALCA 47 0.70 18.14 28.76 99.16
79 INT10272 Gene_expression of Il1b 194 0.78 121.02 103.03 99.16
80 INT467 Gene_expression of POMC 1048 0.78 332.8 394.16 99.00
81 INT95 Positive_regulation of Adrb1 34 0.62 11.95 14.41 98.80
82 INT82347 Regulation of PLXNA3 5 0.60 4.59 2.45 98.74
83 INT8337 Negative_regulation of Gene_expression of Gnrh1 14 0.58 4.63 5.32 98.74
84 INT2197 Gene_expression of Gnrh1 184 0.78 40.04 50.57 98.74
85 INT3987 Positive_regulation of IGHE 316 0.70 283.2 40.16 98.72
86 INT67682 Localization of Bdnf 204 0.81 72.36 88.92 98.68
87 INT47683 Negative_regulation of Bdnf 92 0.59 47.53 43.55 98.68
88 INT6490 Negative_regulation of ADCY1 145 0.58 26.25 70.96 98.56
89 INT54681 Negative_regulation of Positive_regulation of ADCY1 16 0.38 2.7 8.14 98.56
90 INT1931 Positive_regulation of Gene_expression of POMC 116 0.70 37.26 38.67 98.52
91 INT5017 Negative_regulation of Tacr1 76 0.58 17 57.07 98.36
92 INT95500 Positive_regulation of Nefh 14 0.50 4.45 12.26 98.36
93 INT156 Negative_regulation of Prl 542 0.59 131.97 192.24 98.32
94 INT1977 Negative_regulation of Positive_regulation of Prl 98 0.59 17.06 47.88 98.32
95 INT1912 Gene_expression of Calca 1152 0.78 453.25 739.84 98.28
96 INT2732 Gene_expression of VIP 74 0.78 24.57 33.72 98.28
97 INT4742 Gene_expression of Tac1 177 0.78 69.99 102.66 98.28
98 INT546 Binding of ALB 311 0.48 85.98 60.14 98.24
99 INT19211 Binding of Shbg 35 0.48 16.29 3.31 98.24
100 INT1599 Positive_regulation of ADCY1 146 0.67 30.05 64.9 98.24
101 INT5372 Localization of LHB 55 0.68 9.47 19 98.20
102 INT9946 Regulation of Localization of LHB 27 0.52 2.47 11.08 98.20
103 INT7040 Binding of Vip 43 0.48 4.57 15.05 98.20
104 INT2867 Gene_expression of CALCA 247 0.78 78.78 138.47 98.16
105 INT15288 Regulation of Hp 11 0.60 3.68 2.89 98.12
106 INT62944 Regulation of Icam1 33 0.47 23.52 7.94 98.08
107 INT3448 Positive_regulation of Gh 521 0.69 180.03 161.18 98.00
108 INT11510 Negative_regulation of Positive_regulation of Gh 28 0.52 12.71 9.16 98.00
109 INT19396 Regulation of Rac1 66 0.53 37.41 30.01 97.92
110 INT7997 Gene_expression of Ltc4s 51 0.76 34.28 13.8 97.88
111 INT11375 Negative_regulation of Es2 10 0.50 6.52 5.64 97.76
112 INT211224 Positive_regulation of Serpind1 8 0.59 12.15 1.8 97.76
113 INT2296 Positive_regulation of Gene_expression of Prl 137 0.70 36.96 35.39 97.64
114 INT1638 Negative_regulation of PLOD1 92 0.59 21.69 26.61 97.56
115 INT5116 Gene_expression of IL2 670 0.78 291.13 146.69 97.52
116 INT5117 Negative_regulation of Gene_expression of IL2 118 0.59 52.33 29.96 97.52
117 INT5680 Gene_expression of Ngf 530 0.78 264.29 310.56 97.48
118 INT16260 Gene_expression of Bdnf 671 0.78 283.44 339.1 97.16
119 INT148 Positive_regulation of Gnrhr 182 0.70 47.44 79.64 96.92
120 INT14506 Regulation of Sst 46 0.62 15.02 22.66 96.80
121 INT6761 Binding of CALCA 100 0.48 26.71 62.05 96.80
122 INT32314 Positive_regulation of Positive_regulation of Pf4 2 0.49 2.65 0.71 96.56
123 INT32315 Positive_regulation of Positive_regulation of PPBP 2 0.49 0.73 0.68 96.56
124 INT11069 Positive_regulation of Pf4 35 0.68 27.7 13.96 96.56
125 INT11071 Positive_regulation of PPBP 43 0.68 26.85 13.43 96.56
126 INT7538 Negative_regulation of IL2 95 0.57 47.31 31.7 96.44
127 INT1309 Positive_regulation of Localization of Gnrhr 152 0.69 24.25 81.56 96.40
128 INT97 Negative_regulation of Adrb1 102 0.59 32.44 26.9 96.36
129 INT17391 Gene_expression of GNAI1 11 0.75 5.26 4.7 96.24
130 INT528 Gene_expression of Prl 693 0.78 217.18 192.2 95.88
131 INT767 Localization of Gnrhr 565 0.80 106.68 214.57 95.80
132 INT1498 Gene_expression of Gh 521 0.75 220.84 81.16 95.76
133 INT24191 Binding of VIP 14 0.40 2.16 6.2 95.68
134 INT9387 Positive_regulation of Cpe 27 0.70 3.99 8.87 95.60
135 INT112730 Positive_regulation of ZNRF1 3 0.06 2.97 0.24 95.36
136 INT203 Positive_regulation of Pomc 257 0.70 90.56 92.84 95.28
137 INT75682 Regulation of Chrna7 14 0.45 10.24 5.25 95.28
138 INT2541 Binding of Calca 200 0.48 67.14 134.62 95.04
139 INT15805 Gene_expression of TFRC 35 0.75 17.44 8.52 94.80
140 INT15798 Positive_regulation of Gene_expression of TFRC 9 0.46 4.99 1.42 94.80
141 INT159518 Gene_expression of Clock 4 0.35 2.34 6.91 94.56
142 INT1197 Negative_regulation of Localization of POMC 109 0.59 28.29 48.02 94.52
143 INT159 Negative_regulation of Localization of Prl 416 0.59 55.34 171.8 94.52
144 INT94629 Negative_regulation of ZNRF1 6 0.36 3.08 1.34 94.44
145 INT127200 Localization of Mcf2l 7 0.64 4.8 3.25 94.28
146 INT25286 Localization of IL1RL1 7 0.56 3.17 2.07 94.28
147 INT443 Localization of POMC 1020 0.81 284.52 443.17 94.00
148 INT756 Gene_expression of C3 138 0.75 100.6 19.2 93.92
149 INT15930 Positive_regulation of Ptprs 8 0.67 7.02 3.48 93.68
150 INT1361 Negative_regulation of Gnrhr 118 0.58 57.77 35.54 93.64
151 INT66531 Gene_expression of Pnoc 88 0.78 22.9 65.11 93.56
152 INT952 Negative_regulation of GHRH 57 0.56 25.3 10.34 93.28
153 INT22831 Negative_regulation of Positive_regulation of IL2 7 0.55 1.7 2.62 93.08
154 INT45014 Regulation of IL1RL1 12 0.14 1.87 2.67 93.04
155 INT127203 Positive_regulation of Mcf2l 14 0.43 9.84 7.03 92.72
156 INT87698 Gene_expression of WAS 25 0.58 8.75 11.83 92.68
157 INT20604 Gene_expression of FAM176C 2 0.65 2.12 0.72 92.56
158 INT8700 Positive_regulation of Positive_regulation of Calca 56 0.67 21.69 53.66 92.44
159 INT83199 Gene_expression of Nos3 193 0.78 100.72 51.57 92.36
160 INT242745 Regulation of FANCE 2 0.28 1.98 0.66 92.32
161 INT48955 Gene_expression of Nos2 753 0.78 403.87 208.08 92.00
162 INT67182 Gene_expression of Tms 10 0.53 5.14 4.29 91.84
163 INT9993 Positive_regulation of Gene_expression of IL2 131 0.69 46.27 30.04 91.80
164 INT4488 Gene_expression of TSHB 10 0.41 4.69 3.09 91.76
165 INT1579 Gene_expression of PRL 279 0.78 119.2 55.41 91.76
166 INT74058 Gene_expression of Nos1 260 0.78 80.04 95.71 91.72
167 INT8835 Localization of SFTPA1 65 0.68 32.81 38.65 91.60
168 INT53240 Positive_regulation of Localization of SFTPA1 11 0.11 7.99 7.15 91.60
169 INT66646 Regulation of Chdh 13 0.44 16.24 8.84 91.52
170 INT22829 Positive_regulation of FCAR 2 0.09 0.51 0.38 91.44
171 INT4759 Negative_regulation of Localization of Calca 294 0.59 82.62 226.45 91.40
172 INT5948 Regulation of Il1b 44 0.60 22.8 25.4 91.20
173 INT20899 Negative_regulation of GNAI1 12 0.57 4.24 6.07 90.92
174 INT51486 Negative_regulation of GNPTAB 11 0.41 8.18 1.45 90.80
175 INT6105 Positive_regulation of IL2 133 0.69 82.76 34.67 90.40
176 INT1530 Regulation of Gh 382 0.61 115.96 112.47 90.40
177 INT3161 Regulation of Localization of Gh 163 0.61 35.43 59.45 90.40
178 INT63553 Binding of PAG1 14 0.48 12.51 14.76 89.60
179 INT167477 Regulation of TREX1 1 0.24 1.04 1.12 89.52
180 INT142735 Regulation of RLS 33 0.53 45.83 11.35 89.44
181 INT142623 Regulation of Gnb3 2 0.42 0.56 1.4 89.20
182 INT75742 Binding of RLS 86 0.42 95.27 19.04 89.04
183 INT6174 Regulation of Gene_expression of POMC 49 0.61 9.75 27.69 88.92
184 INT38963 Binding of Lsd 7 0.41 1.91 4.12 88.92
185 INT8784 Negative_regulation of Positive_regulation of Calca 40 0.59 14.67 33.49 88.64
186 INT11077 Positive_regulation of Htr3a 63 0.67 15.61 22.7 88.56
187 INT10184 Regulation of EDN1 44 0.62 23.78 10.06 88.48
188 INT2389 Regulation of PTGS1 86 0.61 31.23 28.95 88.48
189 INT8787 Negative_regulation of WAS 4 0.42 2.42 1.81 88.36
190 INT2211 Negative_regulation of Abat 267 0.59 66.51 200.98 87.96
191 INT1635 Gene_expression of Vip 245 0.78 53.36 88.13 87.84
192 INT167894 Negative_regulation of PTS 3 0.14 3.96 1.54 87.84
193 INT34829 Positive_regulation of Gnat3 27 0.46 5.24 4.14 87.40
194 INT48767 Negative_regulation of NOS1 312 0.59 154.25 90.32 87.12
195 INT36428 Binding of Chdh 42 0.47 48.04 26.54 87.00
196 INT5200 Gene_expression of Fos 3083 0.78 894.43 1639.02 86.72
197 INT5202 Positive_regulation of Gene_expression of Fos 1163 0.70 319.28 684 86.72
198 INT5358 Positive_regulation of Protein_catabolism of Abat 2 0.38 1.28 1.89 86.64
199 INT5359 Protein_catabolism of Abat 12 0.62 5.11 8.54 86.36
200 INT8490 Negative_regulation of CALCA 87 0.59 29.73 51.34 85.68
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