P:Cocaine

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pChart

Pain Term
Category Drug
Synonyms None
Pain Specific No
Documents 5129
Hot Single Events 200
Hot Interactions 101

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported for Cocaine. They are ordered first by their pain relevance and then by number of times they were reported for Cocaine. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT169218 Binding of EGFR and Coc 1 0.06 2.8 5.85 100.00
2 INT169217 Binding of Pebp1 and Coc 1 0.00 0.22 0.67 100.00
3 INT169219 Binding of OPRM1 and Coc 1 0.01 0.22 0.67 100.00
4 INT169215 Binding of OPRM1 and CARTPT 1 0.00 0.22 0.67 100.00
5 INT169213 Binding of EGFR and CARTPT 1 0.00 0.22 0.67 100.00
6 INT85252 Negative_regulation of Chi3l1 Positive_regulation of Casp3 1 0.01 0 2.26 100.00
7 INT85251 Chi3l1 Positive_regulation of Casp3 1 0.01 0 2.25 100.00
8 INT172500 Ednra Positive_regulation of Coc 1 0.01 1 1.2 100.00
9 INT106753 Pes1 Negative_regulation of Gene_expression of Casp3 2 0.12 0 2.19 100.00
10 INT106752 Negative_regulation of Pes1 Positive_regulation of Casp3 1 0.12 0 0.63 100.00
11 INT106750 Pes1 Negative_regulation of Positive_regulation of Casp3 3 0.23 0 2.35 100.00
12 INT106751 Pes1 Negative_regulation of Casp3 2 0.23 0 1.54 100.00
13 INT63939 Vta1 Positive_regulation of Th 1 0.14 0 1.61 100.00
14 INT77330 Oprk1 Regulation of Localization of GRIN1 1 0.24 0 0.91 100.00
15 INT96545 Nacc1 Regulation of Gene_expression of Penk 1 0.05 0 0.41 100.00
16 INT63940 Negative_regulation of Vta1 Positive_regulation of Th 1 0.13 0 0.81 100.00
17 INT144367 Gdnf Negative_regulation of Positive_regulation of Th 1 0.11 0.77 0.7 100.00
18 INT148629 Binding of Cat and Casp3 1 0.08 0.09 0.26 100.00
19 INT214370 Slc6a3 Regulation of Amph 1 0.14 0.44 0.82 100.00
20 INT106754 Pes1 Positive_regulation of Casp3 1 0.13 0 0.63 99.98
21 INT147885 Negative_regulation of Slc6a3 Positive_regulation of Positive_regulation of Casp3 1 0.13 0 0.88 99.98
22 INT353372 Dio1 Positive_regulation of Grin1 1 0.16 0 0.98 99.86
23 INT119713 Negative_regulation of Slc6a3 Positive_regulation of Cpu3 1 0.39 0.71 1.26 99.84
24 INT307045 Tmie Negative_regulation of Positive_regulation of Casp3 1 0.01 0.29 0.85 99.84
25 INT48148 Fos Positive_regulation of Gene_expression of Pdyn 1 0.21 0 0.94 99.82
26 INT286702 Positive_regulation of Mapk1 Positive_regulation of Positive_regulation of Rps6ka5 1 0.37 0.18 0.29 99.72
27 INT286705 Positive_regulation of Mapk1 Positive_regulation of Phosphorylation of Rps6ka5 1 0.37 0.18 0.29 99.72
28 INT286699 Positive_regulation of Mapk1 Positive_regulation of Phosphorylation of Creb1 1 0.22 0.18 0.28 99.72
29 INT127437 deltaFosB Negative_regulation of Vta1 1 0.01 0.09 1.06 99.66
30 INT344923 Binding of CEBPZ and GOPC 1 0.06 0.24 0.33 99.64
31 INT311612 Binding of Drd2 and Sert1 1 0.12 0.65 0.86 99.58
32 INT60990 Bdnf Negative_regulation of Th 1 0.15 0 1.17 99.52
33 INT144108 Binding of SLC6A3 and SLC6A4 1 0.12 0.64 1.03 99.50
34 INT87613 LMOD1 Positive_regulation of Fos 1 0.00 0.15 0.56 99.40
35 INT241614 CCNA2 Regulation of PRB3 1 0.06 0 0.37 99.32
36 INT286703 Mapk1 Positive_regulation of Phosphorylation of Hist1h3f 1 0.22 0.18 0.29 99.32
37 INT286706 Mapk1 Positive_regulation of Phosphorylation of Rps6ka5 1 0.37 0.18 0.29 99.32
38 INT286704 Mapk1 Positive_regulation of Phosphorylation of Creb1 1 0.32 0.18 0.28 99.32
39 INT286709 Mapk1 Positive_regulation of Rps6ka5 Positive_regulation of Rps6ka5 1 0.36 0.18 0.28 99.32
40 INT286707 Mapk1 Positive_regulation of Positive_regulation of Rps6ka5 1 0.37 0.18 0.28 99.32
41 INT117909 Mastl Positive_regulation of Mapk1 1 0.04 0 0.79 99.30
42 INT60992 Ngf Regulation of CRTAC1 1 0.00 0 1.35 99.24
43 INT60989 Ngf Regulation of Th 1 0.17 0 1.34 99.24
44 INT69767 Binding of Htr1a and Ptgdr 1 0.23 0 0.97 99.08
45 INT300608 Arc Regulation of Dnm2 1 0.15 0.27 0.37 98.76
46 INT300610 Rorb Regulation of Dnm2 1 0.01 0.27 0.37 98.60
47 INT286701 Rps6ka5 Positive_regulation of Phosphorylation of Creb1 1 0.20 0.18 0.28 98.44
48 INT63161 Akr1d1 Regulation of Gene_expression of Pdyn 1 0.01 0 0.59 98.36
49 INT191332 AMPH Positive_regulation of Mapk1 1 0.76 0 0.66 98.22
50 INT191330 AMPH Positive_regulation of Vta1 1 0.07 0 0.66 98.22
51 INT191331 AMPH Positive_regulation of Gene_expression of Vta1 1 0.07 0 0.66 98.22
52 INT257895 Positive_regulation of Sostdc1 Positive_regulation of Positive_regulation of GRIN1 1 0.00 0.09 0.83 98.12
53 INT112399 Olr897-ps Regulation of Gene_expression of Casp3 1 0.03 0 0.54 97.88
54 INT257896 Sostdc1 Positive_regulation of Positive_regulation of GRIN1 1 0.00 0.09 0.83 97.74
55 INT131040 Binding of Oprm1 and S100a9 1 0.24 0 1.45 97.52
56 INT272039 Ddc Positive_regulation of Gene_expression of Aanat 1 0.00 0.26 0.87 97.00
57 INT51201 Negative_regulation of Binding of OPRM1 and PENK 1 0.20 0.23 0.98 96.68
58 INT101718 PLAT Positive_regulation of Transcription of OPRM1 1 0.22 0.06 0.61 96.32
59 INT214376 Ubqln1 Regulation of Flvcr2 1 0.00 0 0.19 96.20
60 INT214368 Pik3cb Regulation of Ubqln1 1 0.01 0.36 0.68 95.96
61 INT132839 TPT1 Regulation of Mapk1 1 0.01 0.07 0.25 95.88
62 INT51200 Binding of OPRM1 and PENK 2 0.17 0.23 1.31 95.56
63 INT89010 Arc Positive_regulation of Insr 1 0.08 0.86 0.59 95.16
64 INT241679 EIF2AK3 Positive_regulation of Atf4 1 0.06 0.46 0.4 94.84
65 INT89012 DST Positive_regulation of Insr 1 0.01 0.86 0.59 94.84
66 INT51198 Positive_regulation of Binding of OPRM1 and PDYN 2 0.18 0.3 2.08 94.76
67 INT51199 Binding of OPRM1 and PDYN 2 0.13 0.3 2.08 94.76
68 INT51203 Binding of OPRK1 and OPRM1 2 0.29 0.3 1.36 94.76
69 INT51204 Positive_regulation of Binding of OPRK1 and OPRM1 1 0.38 0.3 1.03 94.76
70 INT89011 Lep Positive_regulation of Insr 1 0.19 2.41 1.57 94.64
71 INT60993 Ntf4 Negative_regulation of Positive_regulation of CRTAC1 1 0.00 0 1.37 94.32
72 INT101926 Binding of Dio1 and Drd2 4 0.28 0.39 1.66 94.32
73 INT74517 Binding of Casp3 and Cnrip1 1 0.31 0 0.51 94.32
74 INT300609 Binding of Ctnnb1 and Wnt2 1 0.02 0.25 0.37 94.08
75 INT52955 Binding of Slc6a3 and Pdpn 1 0.17 1.11 1.22 93.16
76 INT52954 Binding of Pdpn and Flvcr2 1 0.05 0.42 0.41 93.16
77 INT131041 Negative_regulation of Binding of Oprm1 and Prf1 1 0.21 0 1.45 93.12
78 INT131039 Binding of Oprm1 and Prf1 1 0.17 0 1.45 93.12
79 INT51202 Positive_regulation of Binding of OPRK1 and PDYN 3 0.00 0.63 3.1 91.44
80 INT51205 Binding of OPRK1 and PDYN 7 0.00 2.01 7.8 90.88
81 INT347802 Grm5 Positive_regulation of Oss1 1 0.12 0.67 0.11 90.28
82 INT50993 Il1b Positive_regulation of Fos 2 0.40 0.43 1.84 89.84
83 INT319558 Positive_regulation of Creb1 Regulation of Srf 1 0.31 0.06 0.04 89.52
84 INT319559 Creb1 Regulation of Srf 1 0.28 0.06 0.04 89.52
85 INT151339 Positive_regulation of Binding of Drd2 and P9Ehs1 1 0.11 0.22 0.76 89.44
86 INT151340 Binding of Drd2 and P9Ehs1 1 0.09 0.22 0.75 89.44
87 INT101716 JUND Regulation of Regulation of OPRM1 1 0.09 0.06 0.65 89.44
88 INT214854 SERPINE1 Positive_regulation of PLAT 1 0.24 0.42 0.33 89.16
89 INT89009 Lep Positive_regulation of Cck 2 0.67 0.43 0.69 87.52
90 INT95378 Binding of Jun and Jund 5 0.20 2.06 1.02 87.40
91 INT232426 HRH2 Regulation of Localization of PRL 1 0.15 0.38 0.94 86.32
92 INT135364 Prr14 Positive_regulation of Mbd1 1 0.22 0.15 0.64 86.12
93 INT135363 Mecp2 Positive_regulation of Mbd1 1 0.50 0.15 0.64 86.12
94 INT33059 Dsp Negative_regulation of Localization of LH 1 0.18 0 0.8 85.64
95 INT135361 Prr14 Positive_regulation of Mecp2 1 0.24 0.15 0.64 85.36
96 INT210144 Binding of Slc6a3 and Slc37a4 1 0.11 0.23 0.72 85.04
97 INT110300 Cartpt Regulation of Adarb1 1 0.14 0 0.49 84.52
98 INT35963 Binding of ALB and MPG 1 0.40 0 0.3 83.36
99 INT319557 Jun Negative_regulation of gr 1 0.05 0.05 0.23 80.92
100 INT351444 Grin1 Positive_regulation of Gria2 1 0.22 1.5 2.64 80.72
101 INT206609 Binding of Col7a1 and Ecm1 1 0.00 0.47 0.33 80.28
102 INT123869 Binding of GNAS and OPRK1 1 0.00 0.37 0.7 79.40
103 INT353718 Binding of Rbm39 and Ghsr 1 0.01 0 0.76 79.28
104 INT135426 Binding of APBB1 and Dlg4 1 0.00 0.17 0.42 79.20
105 INT191328 Mir327 Negative_regulation of Mdk 1 0.00 0 0.28 79.00
106 INT101715 PLAT Positive_regulation of NFKB1 2 0.11 0.99 1.09 78.48
107 INT101719 PLAT Positive_regulation of NFYC 1 0.13 0.1 0.6 78.48
108 INT101717 PLAT Positive_regulation of JUND 1 0.17 0.1 0.59 78.48
109 INT319556 Positive_regulation of Jun Negative_regulation of Positive_regulation of gr 1 0.05 0.17 0.24 78.44
110 INT319555 gr Positive_regulation of Positive_regulation of Hpse 1 0.09 0.11 0.22 78.44
111 INT353721 Negative_regulation of Binding of Drd1a and Ghsr 1 0.16 0 0.76 78.00
112 INT353720 Binding of Drd1a and Ghsr 1 0.18 0 0.76 78.00
113 INT282501 Negative_regulation of Cyp19a1 Negative_regulation of Gene_expression of Aaiq4 1 0.01 0.6 0.27 77.84
114 INT206608 Binding of Ecm1 and Itgb5 1 0.02 0.41 0.33 77.76
115 INT277615 Positive_regulation of Binding of ZNF238 and Hdac3 1 0.38 0.06 0.07 77.68
116 INT277614 Binding of ZNF238 and Hdac3 1 0.29 0.06 0.07 77.68
117 INT329451 Binding of Oprd1 and Tacr1 1 0.05 0.23 1.41 77.64
118 INT329452 Binding of Tac1 and Oprd1 1 0.01 0.23 1.4 77.08
119 INT191329 Mir327 Negative_regulation of Mapk1 1 0.01 0 0.18 76.72
120 INT214372 Ptprq Positive_regulation of Akt1 1 0.04 0.88 1.43 76.48
121 INT214369 Pik3cb Positive_regulation of Akt1 1 0.56 0.87 1.41 76.48
122 INT135425 Binding of Dlg4 and Dlg3 1 0.29 0.07 0.28 76.28
123 INT337112 Negative_regulation of Nr1d2-rs2 Positive_regulation of Mapk1 1 0.00 0.14 0.33 75.64
124 INT337110 Negative_regulation of Nr1d2-rs2 Positive_regulation of Phosphorylation of Hist1h3f 1 0.00 0.14 0.33 75.64
125 INT319554 Sgk1 Regulation of Cdkn1a 1 0.26 0.09 0.45 75.28
126 INT135360 Binding of Mecp2 and Aadac 1 0.03 0.19 0.51 75.00
127 INT114676 Mdm2 Negative_regulation of p53-ps 1 0.10 0.26 0.48 75.00
128 INT136143 Positive_regulation of Binding of Agrp and Hsd11b1 1 0.43 0.56 0.3 73.96
129 INT158621 Binding of SIGMAR1 and Sphk1 1 0.01 0 0.25 73.56
130 INT149322 Amph Positive_regulation of Akt1 1 0.39 0 0.27 73.44
131 INT136142 Binding of Agrp and Hsd11b1 1 0.33 0.56 0.3 73.04
132 INT149321 Amph Positive_regulation of Trib3 1 0.16 0 0.54 72.96
133 INT222558 Mzb1 Regulation of Localization of Prl 1 0.13 0.14 0.1 72.80
134 INT110274 Binding of Fdps and Plin2 1 0.00 0.22 0.18 71.32
135 INT341779 DBT Positive_regulation of PRKCA 1 0.02 0 0.22 67.92
136 INT341778 DBT Positive_regulation of MAP2K6 1 0.00 0 0.21 67.60
137 INT214977 Binding of Jun and Sigmar1 1 0.01 0.27 0.24 67.04
138 INT245348 Binding of Abat and Vta1 1 0.03 0.53 2.01 66.72
139 INT295546 Ghrl Positive_regulation of Ghsr 3 0.39 0.09 0.77 65.76
140 INT337111 Positive_regulation of Nr1d2-rs2 Negative_regulation of Positive_regulation of Mapk1 1 0.00 0.15 0.31 65.40
141 INT156462 Creb1 Regulation of Ephb1 1 0.29 0 1.07 65.16
142 INT99797 Jun Positive_regulation of Creb1 1 0.15 0.19 0.2 64.56
143 INT245349 Binding of Abat and Gpr156 1 0.02 0.26 1 64.40
144 INT353716 Ghrl Positive_regulation of Vta1 1 0.33 0 0.74 63.52
145 INT222546 Mzb1 Positive_regulation of Localization of Prl 1 0.10 0.17 0.12 62.88
146 INT282506 ocd Positive_regulation of Gene_expression of Comt 1 0.32 1.26 0.84 62.20
147 INT105716 Vta1 Regulation of Nfasc 1 0.14 0 1.89 62.04
148 INT105717 Vta1 Regulation of Nfasc Regulation of Nfasc 1 0.15 0 0.63 62.04
149 INT258574 Cysltr1 Positive_regulation of Positive_regulation of Cnr1 1 0.01 0.07 0.32 59.80
150 INT253836 Cck Regulation of DST 1 0.03 0.42 0.95 58.40
151 INT253826 Cck Regulation of Nts 1 0.21 0.36 0.94 58.40
152 INT40114 Binding of OPRD1 and Oprm1 2 0.00 0 4.29 58.16
153 INT214149 Binding of Lepr and Pomc 1 0.33 0.21 0.03 56.88
154 INT214167 Binding of DST and Pomc 1 0.03 0.22 0.03 56.88
155 INT79094 PDYN Positive_regulation of PRL 1 0.35 0.09 1.07 56.72
156 INT214171 Binding of DST and Cartpt 1 0.01 0.21 0.03 56.68
157 INT214148 Binding of Lepr and Cartpt 1 0.09 0.21 0.03 56.68
158 INT264568 Binding of STS and CYP1A2 1 0.20 0.18 0.06 56.04
159 INT222477 Mzb1 Positive_regulation of Gene_expression of Prl 1 0.10 0.1 0.03 55.24
160 INT315334 Binding of CYP3A4 and CDIPT 3 0.04 0.85 0.59 54.20
161 INT253637 TNF Regulation of Transcription of HIVEP1 1 0.07 1.72 0.26 53.80
162 INT329278 Vta1 Positive_regulation of Gene_expression of Fos 1 0.22 0 0.82 52.92
163 INT154782 Binding of SLC6A4 and Ndst2 1 0.01 0 0.37 52.48
164 INT280451 IER5 Positive_regulation of Phc1 1 0.00 0.56 0.09 52.48
165 INT214978 Positive_regulation of Sigmar1 Positive_regulation of Positive_regulation of Fosl2 1 0.01 0.23 0.16 51.12
166 INT81064 Negative_regulation of Nts Negative_regulation of Gene_expression of Homer1 1 0.01 0 0.48 50.68
167 INT337113 Ppp1r1b Negative_regulation of Phosphorylation of Cdk5 1 0.11 0.28 0.27 50.40
168 INT7022 Drd1a Positive_regulation of Npr1 6 0.05 0.26 4.32 50.00
169 INT13205 Oprd1 Negative_regulation of Npr1 2 0.01 0 1.16 50.00
170 INT253827 Cck Regulation of Cartpt 1 0.41 0 1.16 50.00
171 INT253828 Creb1 Positive_regulation of Gene_expression of Cartpt 1 0.19 0.15 0.72 50.00
172 INT253829 Atf6b Positive_regulation of Gene_expression of Cartpt 1 0.24 0.15 0.72 50.00
173 INT253833 Positive_regulation of Atf6b Positive_regulation of Gene_expression of Cartpt 1 0.24 0.15 0.72 50.00
174 INT253831 Cck Positive_regulation of Gene_expression of Cartpt 1 0.48 0.23 0.69 50.00
175 INT253825 Cck Positive_regulation of Crh 1 0.74 0 0.69 50.00
176 INT253830 Cck Positive_regulation of Crh 1 0.38 0 0.68 50.00
177 INT253834 Cck Regulation of Lep 1 0.19 0.23 0.55 50.00
178 INT253835 Binding of DST and Fos 1 0.02 0 0.55 50.00
179 INT253832 Binding of Fos and Nts 1 0.14 0 0.54 50.00
180 INT89016 Oprd1 Negative_regulation of Drd1a 1 0.06 0 0 50.00
181 INT264988 Binding of CYP2C19 and CYP3A4 1 0.18 0.72 1.09 49.12
182 INT264987 Binding of CYP2C9 and CYP3A4 1 0.19 0.71 1.08 48.76
183 INT201241 Positive_regulation of GDI2 Positive_regulation of Regulation of AGFG1 1 0.01 0 0.82 48.72
184 INT351446 Gria2 Negative_regulation of Casp3 1 0.02 0.37 0.47 47.20
185 INT277613 Binding of HDAC9 and Runx2 1 0.02 0.59 0.26 45.84
186 INT136141 Hsd11b1 Positive_regulation of Gene_expression of Agrp 1 0.64 0.2 0.47 44.96
187 INT112914 Ppp1r1b Negative_regulation of Prkaca 3 0.22 0.13 0.86 44.80
188 INT99292 Pth Positive_regulation of Jun 1 0.10 0.13 0.36 44.36
189 INT302871 Negative_regulation of Adora2a Positive_regulation of Phosphorylation of Th 1 0.26 0.12 0.4 43.68
190 INT245350 Abat Regulation of Dbh 1 0.00 0.37 0.8 40.72
191 INT47694 sps Regulation of Ntrk2 1 0.00 0.98 0.2 40.04
192 INT47695 sps Regulation of Bdnf 1 0.00 0.98 0.2 40.04
193 INT151338 Binding of Dio1 and P9Ehs1 1 0.09 0.16 0.52 39.44
194 INT276759 ABCB1 Regulation of TOP2A 1 0.04 0.61 0 39.36
195 INT311613 Binding of Slc6a4 and Pten 1 0.24 0.32 0.21 37.88
196 INT270938 Binding of Pick1 and Wnt2 1 0.00 0.18 0.03 37.80
197 INT214375 Amph Regulation of Ubqln1 1 0.00 0 0.16 37.12
198 INT222541 Npy Positive_regulation of Localization of Prl 1 0.07 0 0 35.08
199 INT212815 WAS Positive_regulation of CNR1 1 0.01 0.62 1.16 32.56
200 INT212824 WAS Positive_regulation of Cnr1 1 0.21 0.62 1.16 32.56

Single Events

The table below shows the top 200 pain related interactions that have been reported for Cocaine. They are ordered first by their pain relevance and then by number of times they were reported in Cocaine. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT81037 Negative_regulation of Slc6a3 70 0.59 15.31 37.01 100.00
2 INT5200 Gene_expression of Fos 3083 0.78 894.43 1639.02 100.00
3 INT5228 Positive_regulation of Fos 934 0.70 209.8 503.87 100.00
4 INT5202 Positive_regulation of Gene_expression of Fos 1163 0.70 319.28 684 100.00
5 INT93360 Gene_expression of Slc6a3 63 0.78 19.54 26.55 100.00
6 INT6824 Regulation of Gene_expression of Pdyn 114 0.62 9.48 66.73 100.00
7 INT797 Regulation of Penk 812 0.62 111.13 542.24 100.00
8 INT5593 Positive_regulation of Gene_expression of Pdyn 114 0.70 29.1 74.46 100.00
9 INT728 Positive_regulation of Penk 1068 0.70 186.9 636.87 100.00
10 INT5587 Regulation of Fos 191 0.62 40.81 99.7 100.00
11 INT68473 Binding of Coc 13 0.40 2.99 8.89 100.00
12 INT5594 Regulation of Pdyn 137 0.62 27.04 86.63 100.00
13 INT6056 Negative_regulation of Gene_expression of Fos 601 0.59 193.05 386.84 100.00
14 INT5501 Regulation of Oprd1 283 0.62 55.1 249.9 100.00
15 INT31116 Gene_expression of Casp3 192 0.78 78.21 57.43 100.00
16 INT64110 Positive_regulation of Gene_expression of Nos1 68 0.70 58.11 51.64 100.00
17 INT2780 Regulation of Gene_expression of Penk 265 0.62 32.45 143.88 100.00
18 INT65600 Positive_regulation of Casp3 376 0.70 198.44 128.03 100.00
19 INT1414 Regulation of Oprl1 169 0.62 32.05 139.99 100.00
20 INT14151 Gene_expression of Casp3 311 0.78 140.26 120.68 100.00
21 INT1898 Regulation of Crh 220 0.62 61.33 102.64 100.00
22 INT22548 Positive_regulation of Casp3 483 0.70 258.78 213.07 100.00
23 INT82984 Gene_expression of Cartpt 27 0.78 3.93 11.55 100.00
24 INT5591 Regulation of Gene_expression of Fos 425 0.62 129.06 265.78 100.00
25 INT339 Regulation of Trh 156 0.62 39.27 83.55 100.00
26 INT49171 Gene_expression of Nos1 241 0.78 140.7 104.76 100.00
27 INT79093 Positive_regulation of Nos1 101 0.70 46.89 59.61 100.00
28 INT5895 Gene_expression of Oprm1 525 0.78 120.67 407.29 100.00
29 INT11159 Gene_expression of EGFR 698 0.78 548.93 25.69 100.00
30 INT53385 Positive_regulation of Gene_expression of FosB 26 0.70 9.18 26.33 100.00
31 INT11010 Regulation of Phosphorylation of Creb1 52 0.62 7.26 29.04 100.00
32 INT57104 Positive_regulation of Coc 6 0.40 1.34 3.83 100.00
33 INT5596 Negative_regulation of Gene_expression of Pdyn 41 0.59 5.34 24.36 100.00
34 INT11622 Gene_expression of Coc 26 0.57 10.56 5.52 100.00
35 INT4738 Regulation of Ppp1r1b 14 0.49 2.41 7.08 100.00
36 INT74563 Positive_regulation of Gene_expression of ROS1 258 0.61 168.18 34.08 100.00
37 INT16714 Regulation of Creb1 64 0.62 22.23 33.56 100.00
38 INT69441 Regulation of Gene_expression of ROS1 38 0.50 26.78 6.78 100.00
39 INT82005 Positive_regulation of Phosphorylation of Ppp1r1b 10 0.69 0 9.51 100.00
40 INT152 Negative_regulation of MBD2 31 0.38 3.95 11.31 100.00
41 INT171145 Positive_regulation of Fig4 274 0.59 93.55 69.81 100.00
42 INT12484 Binding of Drd2 45 0.48 15.17 24.72 100.00
43 INT11154 Binding of EGFR 149 0.48 96.23 6.29 100.00
44 INT57024 Regulation of Gene_expression of Grin1 32 0.62 9.77 32.6 100.00
45 INT440 Regulation of Gene_expression of Crh 44 0.62 17.71 20.73 100.00
46 INT1616 Regulation of Gad1 46 0.61 10.2 28.64 100.00
47 INT105103 Regulation of Gene_expression of Casp3 11 0.39 3.15 9.22 100.00
48 INT2451 Positive_regulation of Avp 355 0.70 102.66 147.69 100.00
49 INT16769 Positive_regulation of Positive_regulation of Oprm1 31 0.57 8.29 29.66 100.00
50 INT35716 Positive_regulation of NCOR2 45 0.60 18 23.54 100.00
51 INT6682 Regulation of Gene_expression of Drd2 13 0.51 2.17 8.82 100.00
52 INT12502 Regulation of Adarb1 50 0.53 7.58 30.01 100.00
53 INT7490 Regulation of Localization of Pdyn 7 0.62 0.14 11.35 100.00
54 INT19408 Negative_regulation of Cyp2c22 37 0.59 6.23 14.22 100.00
55 INT18518 Regulation of Regulation of Pdyn 6 0.60 0 3.6 100.00
56 INT47741 Negative_regulation of Flvcr2 43 0.51 5.72 23.37 100.00
57 INT175526 Phosphorylation of Gopc 73 0.53 21.08 7.86 100.00
58 INT5453 Regulation of Localization of POMC 114 0.62 20.56 56.34 100.00
59 INT87698 Gene_expression of WAS 25 0.58 8.75 11.83 100.00
60 INT92741 Positive_regulation of Positive_regulation of Nos1 8 0.47 1.44 6.58 100.00
61 INT1395 Negative_regulation of Penk 537 0.59 87.33 389.81 100.00
62 INT10483 Regulation of Phosphorylation of Ppp1r1b 8 0.62 0.73 5.8 100.00
63 INT11519 Negative_regulation of Coc 8 0.50 3.96 2.74 100.00
64 INT66811 Positive_regulation of Transcription of Avp 11 0.70 2.1 6.46 100.00
65 INT29045 Regulation of Etf1 10 0.05 5.93 8.7 100.00
66 INT7899 Positive_regulation of Gene_expression of Homer1 41 0.70 7.29 25.98 100.00
67 INT241620 Negative_regulation of Positive_regulation of Atf4 1 0.27 0.85 0.88 100.00
68 INT56686 Regulation of Vta1 26 0.44 3.43 24.48 100.00
69 INT5378 Regulation of Gene_expression of Fos 47 0.60 14.47 26.41 100.00
70 INT23738 Regulation of Transcription of Oprd1 6 0.26 0.48 4.3 100.00
71 INT90313 Negative_regulation of Gene_expression of Casp3 57 0.57 22.23 26.77 100.00
72 INT11624 Gene_expression of OPRM1 445 0.78 72.36 294.36 100.00
73 INT5774 Regulation of Ppt1 22 0.60 4.97 7.1 100.00
74 INT12575 Regulation of Hpse 33 0.59 17.7 18.45 100.00
75 INT27493 Negative_regulation of Casp3 114 0.56 56.89 44.63 100.00
76 INT5931 Regulation of Oprm1 149 0.62 18.15 125.93 100.00
77 INT65598 Negative_regulation of Positive_regulation of Casp3 45 0.59 18.36 28.59 100.00
78 INT57734 Binding of SLC6A4 36 0.48 11.94 15.42 100.00
79 INT6294 Regulation of Gene_expression of Oprm1 28 0.62 6.77 22.79 100.00
80 INT7903 Positive_regulation of Fosl1 21 0.70 3.53 11.36 100.00
81 INT13290 Binding of Atxn2l 34 0.18 1.86 28.16 100.00
82 INT18032 Positive_regulation of Oprk1 108 0.70 30.78 89.7 100.00
83 INT64530 Negative_regulation of Positive_regulation of Pde2a 1 0.36 0 1.81 100.00
84 INT30172 Positive_regulation of Pde2a 3 0.39 0.55 2.77 100.00
85 INT29020 Positive_regulation of pcp 18 0.45 3.5 6.39 100.00
86 INT13838 Positive_regulation of Drd1a 48 0.70 9.83 23.42 100.00
87 INT169212 Positive_regulation of Binding of Coc 1 0.28 0.87 0.58 100.00
88 INT5858 Positive_regulation of Drd1a 66 0.69 4.51 51.73 100.00
89 INT66424 Regulation of SLC43A3 7 0.32 2.33 2.33 100.00
90 INT11623 Regulation of Coc 3 0.38 0.66 1.66 100.00
91 INT18245 Negative_regulation of Localization of Crhr1 4 0.17 0.28 4.81 100.00
92 INT11307 Negative_regulation of pcp 30 0.48 7.86 11.53 100.00
93 INT104092 Regulation of Sstr4 1 0.39 0 1.36 100.00
94 INT9236 Regulation of Gene_expression of TNF 204 0.62 162.66 72.99 100.00
95 INT241626 Negative_regulation of Regulation of Atf4 1 0.28 0.29 0.48 100.00
96 INT78697 Negative_regulation of Gene_expression of Casp3 33 0.57 11.22 16.16 100.00
97 INT9780 Regulation of Penk 30 0.60 6.78 17.19 100.00
98 INT49552 Negative_regulation of Positive_regulation of Casp3 76 0.55 36.04 44.78 100.00
99 INT70858 Negative_regulation of Binding of Coc 1 0.22 0 1.12 100.00
100 INT70859 Regulation of Binding of Coc 1 0.14 0 1.18 100.00
101 INT6054 Positive_regulation of Gene_expression of Egr1 67 0.70 18.45 25.93 100.00
102 INT113 Positive_regulation of MBD2 33 0.49 6.76 7.49 100.00
103 INT272768 Gene_expression of Nrxn3 5 0.78 4.73 3.31 100.00
104 INT78695 Regulation of Casp3 24 0.44 9.43 10.48 100.00
105 INT5862 Positive_regulation of Egr1 82 0.70 30.4 33.96 100.00
106 INT69621 Positive_regulation of Positive_regulation of Hpse 7 0.42 4.1 2.85 100.00
107 INT50559 Binding of A1cf 4 0.34 0.8 2.97 100.00
108 INT22546 Positive_regulation of Gene_expression of Casp3 97 0.70 47.89 51.92 100.00
109 INT15198 Regulation of Gene_expression of Gtf3a 13 0.10 8.63 3.34 100.00
110 INT125622 Regulation of NLRP1 7 0.44 1.84 3.62 100.00
111 INT106749 Negative_regulation of Negative_regulation of Casp3 6 0.34 5.12 1.48 100.00
112 INT170444 Binding of Gopc 172 0.39 45.05 20.71 100.00
113 INT90727 Negative_regulation of Gene_expression of FosB 4 0.54 0.5 3.37 100.00
114 INT24836 Negative_regulation of Positive_regulation of Pdyn 4 0.38 0.44 1.85 100.00
115 INT5503 Negative_regulation of Gene_expression of Crh 38 0.59 16.82 21.34 100.00
116 INT15610 Localization of GOPC 223 0.65 68.26 28.7 100.00
117 INT344929 Localization of AOC2 1 0.31 0.2 0.45 100.00
118 INT82009 Negative_regulation of Phosphorylation of Ppp1r1b 7 0.58 0.85 4.94 100.00
119 INT241667 Positive_regulation of Regulation of CCNA2 1 0.32 0 0.35 100.00
120 INT66987 Regulation of Th 23 0.61 7.86 6.8 100.00
121 INT21999 Regulation of Gene_expression of IGHG3 8 0.30 3.26 1.84 100.00
122 INT17275 Gene_expression of HIVEP1 267 0.75 232.07 24.06 100.00
123 INT206592 Negative_regulation of Localization of Nlrp1a 2 0.06 0.47 1.75 100.00
124 INT147574 Gene_expression of Scrg1 5 0.02 1.4 2.46 100.00
125 INT40800 Regulation of Gene_expression of Oprl1 8 0.61 1.82 4.73 100.00
126 INT214106 Gene_expression of Cartpt 21 0.73 3.68 7.84 100.00
127 INT54617 Positive_regulation of Gene_expression of Abcb1b 22 0.67 9.8 5.34 100.00
128 INT28729 Negative_regulation of Negative_regulation of Oprd1 3 0.43 0.33 2.79 100.00
129 INT3118 Negative_regulation of Positive_regulation of POMC 33 0.59 9.42 18.07 100.00
130 INT77326 Regulation of Localization of Hmmr 1 0.05 0 0.89 100.00
131 INT7090 Gene_expression of pcp 50 0.66 13.54 8.96 100.00
132 INT5854 Regulation of Gene_expression of Penk 22 0.61 6.91 10.03 100.00
133 INT104040 Regulation of Crhr2 2 0.36 1.29 0.81 100.00
134 INT116131 Gene_expression of Commd3 2 0.53 0.68 1.21 100.00
135 INT1711 Negative_regulation of Positive_regulation of Penk 54 0.59 6.55 32.42 100.00
136 INT56915 Positive_regulation of Positive_regulation of IgG-2a 1 0.09 0.13 1.09 100.00
137 INT50991 Regulation of Nacc1 3 0.05 7.25 4.7 100.00
138 INT50990 Regulation of Cpb2 12 0.37 2.71 7.07 100.00
139 INT172499 Localization of Coc 4 0.64 0.96 0.37 100.00
140 INT128320 Regulation of Gene_expression of Npas2 1 0.43 0.18 1.38 100.00
141 INT133703 Negative_regulation of Phosphorylation of Trh 4 0.19 0.85 1.88 100.00
142 INT168269 Negative_regulation of Positive_regulation of Ppara 3 0.38 0.57 1.87 100.00
143 INT61864 Regulation of Gene_expression of Gria1 24 0.62 13.27 14.3 100.00
144 INT128324 Regulation of Gene_expression of Per1 11 0.61 1.95 5.22 100.00
145 INT78441 Positive_regulation of Positive_regulation of DUSP8 1 0.01 0.18 0.72 100.00
146 INT53188 Regulation of Gene_expression of VSX1 4 0.40 1.41 1.66 100.00
147 INT8526 Negative_regulation of Positive_regulation of Fos 26 0.59 5.99 17.52 100.00
148 INT5932 Regulation of Regulation of Oprm1 7 0.61 0.44 6.47 100.00
149 INT78694 Positive_regulation of Gene_expression of Casp3 46 0.66 18.64 19.62 100.00
150 INT36121 Regulation of CLPP 4 0.59 0.78 1.39 100.00
151 INT300602 Negative_regulation of Adora2b 1 0.38 0 0.59 100.00
152 INT3375 Gene_expression of IGHE 535 0.77 387.47 65.46 100.00
153 INT15197 Regulation of Gene_expression of Ifng 8 0.34 2.66 2.69 100.00
154 INT142637 Positive_regulation of Gene_expression of PRTN3 8 0.46 6.23 1.75 100.00
155 INT50989 Regulation of Positive_regulation of Il1b 2 0.42 0.86 1.02 100.00
156 INT51551 Regulation of Transcription of Kcnh7 1 0.05 0 0.59 100.00
157 INT51550 Regulation of Kcnh7 1 0.05 0 0.59 100.00
158 INT87701 Negative_regulation of Positive_regulation of WAS 2 0.36 0.58 0.64 100.00
159 INT5860 Regulation of Gene_expression of Egr1 20 0.62 3.02 6.38 100.00
160 INT128318 Regulation of Gene_expression of Aanat 1 0.33 0.09 0.76 100.00
161 INT52151 Negative_regulation of Gene_expression of Insig1 1 0.08 0 1 100.00
162 INT128326 Regulation of Gene_expression of Cry2 1 0.03 0.09 0.68 100.00
163 INT128321 Regulation of Gene_expression of Cry1 2 0.34 0.09 1.38 100.00
164 INT128316 Regulation of Gene_expression of Arntl 6 0.43 0.68 1.43 100.00
165 INT128323 Regulation of Gene_expression of Per3 1 0.21 0.09 0.69 100.00
166 INT128327 Regulation of Gene_expression of Per2 9 0.45 1.11 1.66 100.00
167 INT264622 Regulation of Positive_regulation of Nlrp1a 1 0.02 0 1.83 100.00
168 INT310381 Positive_regulation of Gene_expression of Nrxn3 1 0.03 1.19 1 100.00
169 INT253814 Regulation of Cartpt 1 0.37 0.28 1.52 100.00
170 INT5859 Positive_regulation of Positive_regulation of Drd1a 20 0.55 2.05 15.61 100.00
171 INT89184 Gene_expression of Mc4r 55 0.77 23.85 10.65 100.00
172 INT1158 Regulation of Agt 106 0.61 29.4 30.29 100.00
173 INT300585 Negative_regulation of Gene_expression of Adora2b 1 0.28 0 0.3 100.00
174 INT31905 Positive_regulation of Binding of Oprd1 21 0.66 3.31 18.44 100.00
175 INT22549 Positive_regulation of Positive_regulation of Casp3 48 0.56 29.5 23.7 100.00
176 INT56883 Positive_regulation of Dll1 8 0.49 3.49 12.25 100.00
177 INT27118 Regulation of Binding of OPRM1 10 0.62 1.18 5.97 100.00
178 INT149641 Binding of Eef1a1 3 0.02 1.72 0.87 100.00
179 INT136139 Transcription of Mc4r 4 0.70 1.83 0.62 100.00
180 INT123977 Binding of Lat 2 0.32 0.56 0.39 100.00
181 INT5595 Positive_regulation of Pdyn 223 0.70 48.37 130.14 99.98
182 INT95787 Positive_regulation of Mapk1 568 0.70 226.51 220.94 99.98
183 INT206950 Positive_regulation of Atf4 14 0.45 7.02 5.71 99.98
184 INT5930 Positive_regulation of Oprm1 221 0.70 31.19 172.93 99.98
185 INT5540 Positive_regulation of Oprm1 344 0.70 76.77 319.71 99.98
186 INT7032 Positive_regulation of Pdyn 94 0.66 26.51 58.83 99.98
187 INT74726 Negative_regulation of Slc6a4 61 0.59 21.01 27.84 99.98
188 INT218 Positive_regulation of Th 245 0.70 40.5 120.1 99.98
189 INT92733 Negative_regulation of Ephb1 19 0.51 8.56 17.72 99.98
190 INT5380 Positive_regulation of Gene_expression of Fos 243 0.70 105.65 131.05 99.98
191 INT17459 Positive_regulation of Gene_expression of FOS 182 0.67 53.45 96.38 99.98
192 INT50 Negative_regulation of Localization of Ren 87 0.59 14.94 30.22 99.98
193 INT1652 Regulation of Pomc 387 0.62 61.01 186.51 99.98
194 INT1377 Positive_regulation of Trh 172 0.70 40.55 69.83 99.98
195 INT7327 Regulation of Th 164 0.62 29.67 110.14 99.98
196 INT5509 Positive_regulation of Localization of Crh 91 0.70 30.65 53.92 99.98
197 INT57878 Positive_regulation of Gene_expression of Egr1 36 0.70 20.42 14.45 99.98
198 INT143964 Positive_regulation of Phosphorylation of Trh 10 0.20 0.1 10.54 99.98
199 INT29105 Positive_regulation of OPRK1 68 0.70 7.06 44.69 99.98
200 INT31774 Positive_regulation of Vta1 67 0.44 14.52 71.79 99.98
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