P:Congenital analgesia

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Pain Term
Category Disorder
Synonyms Analgesia Congenital, Congenital Indifference To Pain, Congenital Insensitivity To Pain, Congenital Pain Indifference, Congenital Pain Indifferences, Pain Indifference Congenital
Pain Specific Yes
Documents 233
Hot Single Events 50
Hot Interactions 1

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported for Congenital analgesia. They are ordered first by their pain relevance and then by number of times they were reported for Congenital analgesia. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT131462 NGF Regulation of Localization of INS 1 0.40 0.97 1.2 96.24
2 INT131463 NTRK1 Regulation of Localization of INS 1 0.41 0.63 0.8 77.52
3 INT24157 Binding of CALCA and SFTPA1 2 0.07 0.96 1.64 76.40
4 INT160578 Binding of CALCA and TAC1 1 0.07 0.91 1.61 76.08
5 INT118980 NTRK1 Positive_regulation of NGF 1 0.56 1.45 1.39 75.00
6 INT82023 Binding of Ntrk1 and Ngf 5 0.53 3.48 3.92 75.00
7 INT118979 NGF Positive_regulation of Phosphorylation of NTRK1 1 0.56 0.67 0.67 75.00
8 INT298876 RAB7A Positive_regulation of Protein_catabolism of NTRK1 1 0.14 0.44 0.22 55.92
9 INT106558 Binding of Ntrk2 and Ntrk3 3 0.52 2.51 2.28 5.00
10 INT317184 BMS1 Regulation of Gene_expression of NAV1 1 0.03 1.94 1.62 5.00
11 INT341336 Binding of Pepd and Nav1 1 0.07 0.92 1.3 5.00
12 INT341479 Binding of SCN2A and SCN4A 1 0.37 1.29 0.98 5.00
13 INT341480 Binding of SCN1A and SCN4A 1 0.36 1.29 0.98 5.00
14 INT223474 Binding of Grik1 and P2rx3 1 0.03 0.36 0.4 5.00
15 INT223470 Ret Regulation of Ntrk1 1 0.21 0 0.36 5.00
16 INT223477 Binding of Ntrk1 and Ntrk3 2 0.16 0.3 0.19 5.00
17 INT223475 Binding of Ntrk1 and Ntrk2 2 0.22 0.25 0.14 5.00
18 INT307529 Binding of IK and TRNAC1 1 0.00 0.07 0.12 5.00
19 INT298831 Binding of MTOR and RAB7A Positive_regulation of MTOR 1 0.02 0.35 0.03 5.00
20 INT298878 Binding of MTOR and RAB7A 1 0.07 0.35 0.03 5.00
21 INT298872 RAB7A Regulation of Protein_catabolism of GFM1 1 0.47 0.22 0.03 5.00
22 INT298873 RAB7A Regulation of Protein_catabolism of NTRK1 1 0.12 0.25 0.03 5.00
23 INT298858 Positive_regulation of Binding of VAPA and RILP 1 0.07 0.54 0 5.00
24 INT298854 Binding of LAMP2 and RAB7A 1 0.16 0.56 0 5.00
25 INT298862 Binding of MCC and VPS13C 1 0.00 0.36 0 5.00
26 INT298879 Binding of MCC and MTG1 1 0.00 0.37 0 5.00
27 INT298863 Binding of VAPB and RILP 1 0.13 0.21 0 5.00
28 INT298875 Binding of RAB7A and VPS13C 1 0.21 0.49 0 5.00
29 INT298845 VAPA Regulation of Negative_regulation of RAB7A 1 0.12 0.32 0 5.00
30 INT298868 Binding of RAB7A and GOPC 1 0.07 1.64 0 5.00
31 INT298848 Binding of SPG21 and RILP 1 0.10 0.21 0 5.00
32 INT223471 Dok4 Regulation of Ret 1 0.30 0.17 0 5.00
33 INT298849 Binding of APOB and MCC 1 0.00 0.38 0 5.00
34 INT298859 Positive_regulation of Binding of MCC and VPS13C 1 0.01 0.36 0 5.00
35 INT298853 Binding of AGFG1 and RILP 1 0.02 0.21 0 5.00
36 INT298856 Binding of APOB and MTG1 1 0.00 0.38 0 5.00
37 INT298866 Binding of AGFG1 and RAB7A 1 0.04 0.21 0 5.00
38 INT298846 Binding of MCC and RILP 1 0.01 0.36 0 5.00
39 INT298850 Binding of RAB7A and MTG1 1 0.01 0.24 0 5.00
40 INT298877 Positive_regulation of Binding of RAB7A and VPS13C 1 0.22 0.49 0 5.00
41 INT223479 Binding of Ntrk2 and Dok5 1 0.26 0.17 0 5.00
42 INT298851 Binding of IK and RAB7A 1 0.02 0.57 0 5.00
43 INT298871 ALOX5AP Positive_regulation of RAB7A 1 0.09 0.35 0 5.00
44 INT298869 Binding of RAB7A and RILP 1 0.25 1.07 0 5.00
45 INT298857 Binding of RILP and MTG1 1 0.01 0.35 0 5.00
46 INT298855 Positive_regulation of Binding of MCC and MTG1 1 0.00 0.37 0 5.00
47 INT298865 Positive_regulation of Binding of RILP and MTG1 1 0.01 0.35 0 5.00
48 INT223478 Binding of Ntrk1 and Dok5 1 0.18 0.17 0 5.00
49 INT223476 Binding of Ntrk3 and Dok5 1 0.20 0.17 0 5.00
50 INT298847 Binding of VAPA and RILP 1 0.05 0.54 0 5.00
51 INT223472 Binding of Dok5 and Rbm39 1 0.01 0.17 0 5.00
52 INT298852 Binding of AGFG1 and MTG1 1 0.00 0 0 5.00
53 INT298864 VAPB Regulation of Negative_regulation of RAB7A 1 0.32 0.32 0 5.00
54 INT298861 Binding of APOB and RAB7A 1 0.00 0.32 0 5.00
55 INT298870 Binding of PDB1 and RAB7A 1 0.51 0.21 0 5.00

Single Events

The table below shows the top 200 pain related interactions that have been reported for Congenital analgesia. They are ordered first by their pain relevance and then by number of times they were reported in Congenital analgesia. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT252968 Positive_regulation of TAF9 11 0.45 5.28 3.68 100.00
2 INT252999 Gene_expression of TAF9 12 0.75 12.65 2.92 100.00
3 INT262317 Binding of TAF9 7 0.31 9.67 2.15 100.00
4 INT22939 Gene_expression of Csf2 164 0.78 85.1 32.22 100.00
5 INT46460 Gene_expression of NAV1 288 0.78 135.51 305.75 99.92
6 INT131413 Positive_regulation of Gene_expression of NAV1 35 0.70 17.5 36.83 99.92
7 INT55224 Gene_expression of DRGX 99 0.31 67.55 67.63 99.92
8 INT106667 Gene_expression of NDRG1 18 0.70 9.96 5.14 99.44
9 INT106668 Positive_regulation of Gene_expression of NDRG1 3 0.10 1.93 2.49 99.44
10 INT156734 Gene_expression of BBC3 3 0.58 2.41 0.46 99.28
11 INT108384 Binding of Ntrk1 28 0.39 10.73 9.09 99.20
12 INT71152 Negative_regulation of NTRK1 15 0.59 10.28 5.5 98.64
13 INT36400 Regulation of SCN10A 7 0.62 2.73 1.97 98.56
14 INT23435 Positive_regulation of NGF 54 0.70 32.41 30.11 97.80
15 INT14823 Gene_expression of MET 103 0.75 51.92 32.48 97.64
16 INT3253 Negative_regulation of Localization of INS 205 0.59 130.39 36.61 96.60
17 INT71150 Binding of NGF 22 0.46 13.67 14.81 96.56
18 INT85048 Regulation of NGF 19 0.62 11.61 10.5 96.24
19 INT2274 Regulation of Localization of INS 101 0.62 41.55 34.79 96.08
20 INT156189 Positive_regulation of Gene_expression of Ntrk1 11 0.49 2.81 2.89 96.00
21 INT812 Localization of INS 1026 0.81 515.6 145.31 95.68
22 INT50971 Gene_expression of Ntrk1 180 0.75 73.52 62.28 95.60
23 INT20216 Localization of NGF 40 0.80 18.16 16.61 95.20
24 INT8572 Negative_regulation of Gene_expression of B3GAT1 1 0.57 0.47 0.4 95.12
25 INT66940 Regulation of RET 7 0.52 5.61 0.69 94.00
26 INT48312 Gene_expression of NTRK1 72 0.78 38.21 22.24 92.72
27 INT81750 Regulation of Ntrk1 13 0.52 6.03 4.37 91.64
28 INT79979 Gene_expression of Ret 94 0.75 19.21 25.51 91.00
29 INT298887 Protein_catabolism of NTRK1 1 0.25 1.1 0.56 90.80
30 INT62373 Negative_regulation of NGF 34 0.59 25.87 22.38 90.72
31 INT251 Regulation of INS 398 0.62 232.47 55.04 90.60
32 INT203 Positive_regulation of Pomc 257 0.70 90.56 92.84 90.00
33 INT1425 Gene_expression of Rbm39 143 0.58 51.32 65.44 89.52
34 INT86769 Positive_regulation of Gene_expression of Rbm39 11 0.25 5.6 3.8 89.52
35 INT236437 Negative_regulation of ARHGAP8 1 0.04 0.88 1.07 89.12
36 INT3252 Negative_regulation of INS 428 0.59 271.65 39.52 89.04
37 INT341482 Gene_expression of NMNAT1 1 0.01 3.24 2.79 89.00
38 INT8571 Gene_expression of B3GAT1 54 0.75 36.85 15.98 88.56
39 INT168682 Localization of NDRG1 3 0.36 0.84 1.45 88.12
40 INT168685 Regulation of Localization of ITGA4 1 0.07 0.61 1.4 88.12
41 INT168684 Regulation of Localization of NDRG1 1 0.10 0.61 1.4 88.12
42 INT168683 Localization of ITGA4 2 0.12 0.61 1.4 88.12
43 INT9556 Negative_regulation of NAV1 47 0.59 28.49 49.33 87.40
44 INT18357 Gene_expression of TRPV1 825 0.78 307.11 382.81 86.08
45 INT101592 Gene_expression of TRPM8 82 0.78 70.61 22.89 86.08
46 INT93165 Gene_expression of TRPV2 32 0.78 12.49 5.62 86.08
47 INT236439 Gene_expression of ARHGAP8 1 0.06 0.62 0.88 86.00
48 INT50676 Regulation of ITGA4 2 0.07 0.6 2.13 85.76
49 INT112291 Binding of Lgals4 4 0.35 0.6 1.75 84.64
50 INT67332 Negative_regulation of ITGA4 8 0.51 7.95 2.14 81.04
51 INT112207 Binding of Nav1 27 0.47 7.1 15.43 79.36
52 INT41789 Negative_regulation of Moxd2 6 0.57 4.03 2.49 78.56
53 INT298929 Negative_regulation of Gene_expression of RAB7A 1 0.35 0.3 0.25 76.08
54 INT229791 Gene_expression of RAB7A 2 0.73 6.48 1.21 75.24
55 INT94450 Gene_expression of Nav1 359 0.78 131.85 275.46 75.04
56 INT4509 Gene_expression of IgG 426 0.76 293.69 56.64 75.00
57 INT12265 Positive_regulation of IgG 168 0.63 104.89 19.76 75.00
58 INT46221 Positive_regulation of Gene_expression of IgG 46 0.53 33.66 7.7 75.00
59 INT48313 Binding of NTRK1 19 0.47 14.44 6.12 75.00
60 INT44717 Gene_expression of TNFSF14 12 0.75 13.44 3.72 75.00
61 INT93109 Phosphorylation of NTRK1 5 0.80 3.22 2.99 75.00
62 INT109638 Gene_expression of TRPM3 11 0.53 1.01 1.55 75.00
63 INT129848 Negative_regulation of CD5 3 0.42 3.01 0.67 75.00
64 INT118981 Positive_regulation of Phosphorylation of NTRK1 1 0.49 0.66 0.66 75.00
65 INT158326 Phosphorylation of Tie1 1 0.16 0.8 0.45 75.00
66 INT66941 Localization of NTRK1 8 0.78 5.89 1.96 74.56
67 INT86649 Binding of SCN10A 2 0.36 1.85 1.1 74.00
68 INT86648 Binding of SCN11A 2 0.36 1.11 1.4 73.68
69 INT15515 Positive_regulation of Crp 700 0.70 604.24 150.15 72.44
70 INT3361 Positive_regulation of Esr1 273 0.69 208.53 44.81 72.44
71 INT14831 Negative_regulation of TNC 18 0.50 8.71 4.61 72.00
72 INT62374 Gene_expression of NGF 158 0.78 77.87 76.45 70.72
73 INT129303 Positive_regulation of NAV1 54 0.70 36.92 57.45 70.64
74 INT21952 Gene_expression of GDNF 42 0.78 20.32 9.62 70.40
75 INT88006 Positive_regulation of GDNF 5 0.45 2.55 2.14 70.40
76 INT86646 Positive_regulation of SCN10A 71 0.69 50.61 13.24 70.16
77 INT94199 Regulation of DRGX 9 0.07 8.31 10.39 69.16
78 INT91043 Regulation of NDRG1 7 0.25 2.66 1.65 68.68
79 INT75999 Gene_expression of BDNF 344 0.78 114.19 83.12 68.00
80 INT101239 Gene_expression of NTF3 9 0.76 5.91 2.97 68.00
81 INT103262 Localization of Nav1 53 0.81 19.23 34.44 67.36
82 INT113377 Positive_regulation of Localization of Nav1 2 0.70 0.23 1.46 67.36
83 INT341334 Negative_regulation of Localization of Nav1 1 0.41 0.22 0.42 67.36
84 INT236438 Regulation of ARHGAP8 1 0.02 0.42 0.57 65.76
85 INT20632 Gene_expression of TNC 72 0.78 30.43 13.16 65.40
86 INT229789 Regulation of RAB7A 4 0.42 7.09 0.72 65.36
87 INT29503 Gene_expression of Mmp2 95 0.77 56.92 31.68 61.48
88 INT298922 Negative_regulation of Protein_catabolism of NTRK1 1 0.11 0.44 0.22 55.92
89 INT67048 Gene_expression of ITGA4 58 0.75 28.93 10.16 54.12
90 INT223444 Binding of Mat1a 3 0.28 2.95 0.52 54.00
91 INT85640 Gene_expression of Tg(CAG-EGFP)D4Nagy 1138 0.72 311.58 119.18 53.04
92 INT341335 Gene_expression of Scn2b 1 0.41 0 0.22 52.24
93 INT226826 Gene_expression of Scn1b 5 0.57 0.52 0.22 51.36
94 INT236441 Localization of ARHGAP8 1 0.06 0.57 0.55 51.12
95 INT236440 Binding of ARHGAP8 1 0.03 0.31 0.38 51.12
96 INT63373 Negative_regulation of Gene_expression of NGF 14 0.57 8.9 7.1 45.56
97 INT237655 Binding of Sfn 1 0.42 3.62 2.55 33.36
98 INT86647 Localization of SCN10A 8 0.78 3.88 4.27 27.04
99 INT86483 Localization of SCN11A 4 0.78 1.25 2.23 26.88
100 INT85767 Gene_expression of Scn9a 11 0.76 9.27 2.74 25.80
101 INT93308 Gene_expression of PIRT 13 0.09 2 2.92 25.40
102 INT78749 Gene_expression of SCN10A 25 0.75 9.23 16.5 25.00
103 INT85214 Gene_expression of SCN11A 24 0.78 4.05 12.5 25.00
104 INT83674 Negative_regulation of SCN10A 14 0.59 7.28 9.65 25.00
105 INT65832 Positive_regulation of PIRT 4 0.07 0.83 1.42 23.16
106 INT341483 Positive_regulation of NMNAT1 1 0.01 0.6 0.76 20.72
107 INT9381 Positive_regulation of TRPV1 523 0.70 187.4 276.05 5.00
108 INT90091 Gene_expression of GOPC 967 0.67 366.22 103.6 5.00
109 INT9382 Regulation of TRPV1 149 0.62 53.99 77.46 5.00
110 INT5770 Binding of Rbm39 88 0.41 13.23 55.5 5.00
111 INT52264 Gene_expression of IK 180 0.77 90.87 51.87 5.00
112 INT111051 Negative_regulation of Nav1 64 0.59 25.51 47.27 5.00
113 INT157666 Positive_regulation of GOPC 335 0.60 120.19 42.75 5.00
114 INT102902 Gene_expression of Ntrk2 152 0.78 81.52 39.43 5.00
115 INT103261 Positive_regulation of Nav1 68 0.70 24.25 39.27 5.00
116 INT116321 Regulation of Nav1 38 0.62 26.62 37.97 5.00
117 INT111052 Positive_regulation of Gene_expression of Nav1 44 0.70 18.98 35.28 5.00
118 INT15610 Localization of GOPC 223 0.65 68.26 28.7 5.00
119 INT123419 Binding of NAV1 37 0.48 7.09 26.43 5.00
120 INT116226 Regulation of NAV1 20 0.51 14.32 25.61 5.00
121 INT50970 Positive_regulation of Ntrk1 51 0.57 29.38 22.83 5.00
122 INT7535 Negative_regulation of Tlr4 111 0.56 56.84 21.37 5.00
123 INT99237 Gene_expression of Ntrk3 84 0.77 38.68 20.77 5.00
124 INT13108 Binding of MTG1 35 0.47 6.36 20.5 5.00
125 INT105021 Binding of GOPC 187 0.40 60.39 20.38 5.00
126 INT124670 Gene_expression of Grik1 53 0.77 4.83 19.13 5.00
127 INT111050 Negative_regulation of Gene_expression of Nav1 23 0.58 5.97 17.06 5.00
128 INT113384 Regulation of Gene_expression of Nav1 20 0.62 8.57 16.15 5.00
129 INT114507 Negative_regulation of Gene_expression of NAV1 17 0.43 7.24 15.93 5.00
130 INT171666 Regulation of GOPC 117 0.39 40.41 15.47 5.00
131 INT67653 Gene_expression of Om 46 0.36 15.28 13.32 5.00
132 INT113490 Gene_expression of SCN9A 22 0.77 5.45 12.27 5.00
133 INT149518 Regulation of Gene_expression of NAV1 7 0.62 6.73 9.62 5.00
134 INT148864 Localization of DRGX 11 0.17 7.67 8.36 5.00
135 INT113987 Localization of IK 29 0.23 16.73 8.25 5.00
136 INT79502 Gene_expression of Pvalb 26 0.78 2.83 7.46 5.00
137 INT197216 Localization of Grik1 9 0.80 0.39 6.78 5.00
138 INT25271 Positive_regulation of MTG1 21 0.67 13.59 5.96 5.00
139 INT142690 Positive_regulation of Gene_expression of DRGX 10 0.23 8.54 5.69 5.00
140 INT103518 Negative_regulation of SCN2A 17 0.57 8.4 5.4 5.00
141 INT23598 Binding of SCN5A 32 0.40 16 5.35 5.00
142 INT178754 Positive_regulation of Localization of GOPC 32 0.43 10.1 4.73 5.00
143 INT197219 Positive_regulation of Gene_expression of Grik1 5 0.69 0.83 4.67 5.00
144 INT39060 Gene_expression of Mpz 45 0.77 21.55 4.3 5.00
145 INT28673 Gene_expression of APOB 51 0.73 34.02 3.95 5.00
146 INT131969 Regulation of Grik1 6 0.61 0.57 3.69 5.00
147 INT111053 Positive_regulation of Positive_regulation of Nav1 4 0.46 2.97 3.53 5.00
148 INT143998 Binding of IK 11 0.34 2.44 3.42 5.00
149 INT66077 Regulation of CHPT1 12 0.38 6.1 3.23 5.00
150 INT317186 Regulation of BMS1 1 0.04 3.9 3.17 5.00
151 INT5363 Negative_regulation of PEPD 11 0.56 6.49 3.11 5.00
152 INT140401 Binding of PEPD 3 0.47 2.22 2.97 5.00
153 INT37152 Localization of Mpz 7 0.68 2.64 2.95 5.00
154 INT41721 Negative_regulation of MTOR 40 0.58 32.49 2.83 5.00
155 INT202527 Negative_regulation of Gene_expression of DRGX 5 0.07 1.53 2.54 5.00
156 INT150339 Gene_expression of F2R 10 0.73 3.59 2.46 5.00
157 INT237653 Gene_expression of Sfn 6 0.59 5.54 2.26 5.00
158 INT152352 Negative_regulation of Localization of DRGX 2 0.07 0.87 2.14 5.00
159 INT114330 Binding of MPZ 21 0.32 25.58 2.14 5.00
160 INT46692 Binding of SCN9A 4 0.36 2.55 2.13 5.00
161 INT317185 Positive_regulation of Positive_regulation of NAV1 1 0.47 1.51 2.08 5.00
162 INT102896 Binding of Ret 8 0.35 1.55 2.03 5.00
163 INT40877 Positive_regulation of APOB 35 0.68 32.47 1.86 5.00
164 INT223447 Regulation of Gene_expression of Ntrk1 7 0.34 1.29 1.82 5.00
165 INT163157 Binding of BMS1 3 0.42 3.6 1.77 5.00
166 INT178188 Positive_regulation of Tlr7 12 0.40 6.33 1.77 5.00
167 INT169720 Positive_regulation of Gene_expression of Om 3 0.04 1.51 1.69 5.00
168 INT168681 Gene_expression of BMS1 5 0.37 2.7 1.62 5.00
169 INT9466 Binding of APOB 27 0.41 19.36 1.56 5.00
170 INT278538 Negative_regulation of Negative_regulation of NAV1 2 0.42 0.84 1.56 5.00
171 INT131968 Transcription of Grik1 3 0.51 1.44 1.51 5.00
172 INT317187 Positive_regulation of BMS1 1 0.04 0.98 1.48 5.00
173 INT168537 Negative_regulation of Gene_expression of Grik1 3 0.57 0.11 1.44 5.00
174 INT46206 Positive_regulation of Scn10a 11 0.60 6.57 1.38 5.00
175 INT229794 Positive_regulation of RAB7A 2 0.65 11.68 1.31 5.00
176 INT130329 Positive_regulation of Gp5 4 0.35 1.04 1.29 5.00
177 INT223446 Gene_expression of Crip2 1 0.65 0.95 1.23 5.00
178 INT341481 Binding of SCN8A 1 0.28 1.47 1.23 5.00
179 INT223448 Localization of Ret 2 0.60 0.58 1.23 5.00
180 INT124069 Localization of Ntrk1 9 0.59 3.32 1.13 5.00
181 INT64732 Positive_regulation of Gene_expression of Mpz 9 0.50 3.99 1.11 5.00
182 INT279394 Positive_regulation of Localization of IK 5 0.09 2.67 1.03 5.00
183 INT115481 Gene_expression of CDSN 6 0.10 2.53 1.03 5.00
184 INT341484 Negative_regulation of SCN1A 1 0.53 1.27 0.94 5.00
185 INT319919 Localization of SCN9A 1 0.51 0.31 0.92 5.00
186 INT76807 Binding of MCC 4 0.36 0.54 0.92 5.00
187 INT319920 Negative_regulation of Localization of SCN9A 1 0.29 0.31 0.92 5.00
188 INT201261 Regulation of AGFG1 4 0.09 2.72 0.9 5.00
189 INT61042 Localization of SPG21 5 0.78 1.42 0.89 5.00
190 INT279821 Regulation of Scn9a 2 0.44 2.79 0.83 5.00
191 INT284844 Regulation of Localization of Nav1 2 0.59 0.18 0.83 5.00
192 INT223188 Gene_expression of Ctf1 3 0.65 1.34 0.82 5.00
193 INT111437 Positive_regulation of MCC 3 0.05 1.48 0.79 5.00
194 INT197206 Regulation of Gene_expression of Grik1 2 0.39 0.13 0.71 5.00
195 INT133089 Negative_regulation of MCC 3 0.41 0.72 0.64 5.00
196 INT246642 Binding of CLTCL1 3 0.17 1.32 0.63 5.00
197 INT157192 Gene_expression of SLITRK1 7 0.28 5.77 0.63 5.00
198 INT223455 Gene_expression of Dok4 1 0.65 0.42 0.6 5.00
199 INT58791 Negative_regulation of Nlrp14 2 0.37 0 0.59 5.00
200 INT223462 Binding of Hoxb4 1 0.01 0.08 0.58 5.00
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