P:Delta-9-tetrahydrocannabinol

Pain Term Category Molecule Synonyms None Pain Specific No Documents 115 Hot Single Events 111 Hot Interactions 13

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported for Delta-9-tetrahydrocannabinol. They are ordered first by their pain relevance and then by number of times they were reported for Delta-9-tetrahydrocannabinol. Please click on the 'INT' link to display more detailed information on each interaction.

Int No	Page link	Interaction String	Documents	TM Confidence	Disease Relevance	Overall Pain Relevance	Term Relevance
1	INT133176	Regulation of Mastl Negative_regulation of Il12a	1	0.01	0.24	0.86	100.00
2	INT133177	Mastl Negative_regulation of Il12a	1	0.01	0.24	0.86	100.00
3	INT121713	WAS Positive_regulation of Gene_expression of SELP	1	0.30	0.49	0.63	100.00
4	INT13349	Binding of Gabrg1 and Mastl	1	0.08	0.24	0.54	100.00
5	INT117909	Mastl Positive_regulation of Mapk1	1	0.04	0	0.79	100.00
6	INT198957	Binding of Cnr1 and Mastl	1	0.00	0	1.31	100.00
7	INT48455	Scd1 Regulation of Penk	1	0.06	0	0.88	97.40
8	INT292598	CNR1 Regulation of ABAT	1	0.08	0.32	0.75	96.96
9	INT292599	CNR1 Regulation of Localization of ABAT	1	0.08	0.32	0.75	96.96
10	INT70670	Scd1 Positive_regulation of Gene_expression of Penk	1	0.11	0.1	0.86	93.64
11	INT198958	Cnr1 Positive_regulation of Kcnj9	1	0.00	0.15	2.24	93.44
12	INT73710	Mastl Positive_regulation of Localization of Oprl1	1	0.02	0	1.26	91.36
13	INT145473	Mastl Positive_regulation of Dnahc8	1	0.07	0.06	1.33	89.16
14	INT145472	D2Mit212 Positive_regulation of Dnahc8	1	0.09	0.16	0.81	56.60
15	INT145475	Negative_regulation of D2Mit212 Positive_regulation of Dnahc8	1	0.08	0.1	0.37	33.68
16	INT145474	D2Mit212 Regulation of Dnahc8	1	0.05	0.08	0.33	25.00
17	INT270044	Il10 Positive_regulation of Positive_regulation of Hmox1	1	0.20	1.59	0.53	5.00
18	INT270043	Binding of Ldlr and Hdl1	1	0.01	2.3	0.43	5.00
19	INT270046	Ido1 Positive_regulation of Positive_regulation of Hmox1	1	0.15	0.8	0.27	5.00
20	INT147144	E2F1 Positive_regulation of Transcription of TYMS	1	0.26	0	0	5.00

Single Events

The table below shows the top 200 pain related interactions that have been reported for Delta-9-tetrahydrocannabinol. They are ordered first by their pain relevance and then by number of times they were reported in Delta-9-tetrahydrocannabinol. Please click on the 'INT' link to display more detailed information on each interaction.

Int No	Page link	Event String	Documents	TM Confidence	Disease Relevance	Overall Pain Relevance	Term Relevance
1	INT87698	Gene_expression of WAS	25	0.58	8.75	11.83	100.00
2	INT33105	Regulation of WAS	11	0.60	3.61	7.18	100.00
3	INT87699	Positive_regulation of WAS	16	0.45	5.84	8.03	100.00
4	INT13348	Negative_regulation of Mastl	11	0.36	3.33	7.28	100.00
5	INT48456	Localization of WAS	6	0.56	1.63	3.95	100.00
6	INT1167	Regulation of Mastl	7	0.53	1.86	3.77	100.00
7	INT4857	Regulation of Tacr1	115	0.62	39.01	84.52	100.00
8	INT2055	Regulation of Gnrh1	185	0.62	23.65	71.26	100.00
9	INT790	Gene_expression of Mastl	22	0.68	4.56	10.23	100.00
10	INT133173	Regulation of Negative_regulation of Il12b	2	0.04	0.52	0.97	100.00
11	INT133171	Regulation of Negative_regulation of Scd2	1	0.01	0.21	0.93	100.00
12	INT133175	Negative_regulation of Scd2	2	0.11	0.31	0.93	100.00
13	INT187376	Regulation of Localization of WAS	1	0.08	0.38	0.86	100.00
14	INT115613	Regulation of Gene_expression of ITGA2B	3	0.44	1.43	0.8	100.00
15	INT187380	Negative_regulation of Localization of WAS	1	0.07	0.38	0.85	100.00
16	INT43374	Binding of Scd	1	0.02	0.09	0.97	100.00
17	INT3854	Binding of SCD	16	0.41	11.14	3.7	100.00
18	INT48454	Localization of Scd1	1	0.39	0	0.62	100.00
19	INT124019	Regulation of Scd1	1	0.01	0	0.31	100.00
20	INT7090	Gene_expression of pcp	50	0.66	13.54	8.96	100.00
21	INT66381	Regulation of Prkaca	40	0.62	13.38	27.96	100.00
22	INT121335	Localization of SCD	10	0.68	6.81	1.51	100.00
23	INT40036	Binding of DLL1	10	0.36	2.88	3.95	100.00
24	INT152338	Binding of FADS3	1	0.00	0	0.33	100.00
25	INT63425	Positive_regulation of Gene_expression of SELP	23	0.67	15.34	3.48	99.98
26	INT121716	Positive_regulation of Gene_expression of ITGB3	1	0.13	0.49	0.63	99.98
27	INT133170	Negative_regulation of Il12b	12	0.05	5.32	1.86	99.98
28	INT156	Negative_regulation of Prl	542	0.59	131.97	192.24	99.98
29	INT95787	Positive_regulation of Mapk1	568	0.70	226.51	220.94	99.96
30	INT103757	Negative_regulation of Il12a	37	0.55	21.62	16.38	99.82
31	INT155	Positive_regulation of Prl	1233	0.70	317.93	457.82	99.78
32	INT49142	Gene_expression of SELP	94	0.75	54.61	11.64	99.70
33	INT728	Positive_regulation of Penk	1068	0.70	186.9	636.87	99.70
34	INT71161	Gene_expression of ITGB3	6	0.26	3.59	1.45	99.70
35	INT18357	Gene_expression of TRPV1	825	0.78	307.11	382.81	99.68
36	INT33895	Positive_regulation of LIF	9	0.67	2.47	2.34	99.60
37	INT16850	Negative_regulation of Localization of Gabrg1	73	0.51	8.28	47.89	99.38
38	INT2651	Positive_regulation of Pomc	403	0.70	95.72	206.24	99.30
39	INT796	Gene_expression of Penk	1902	0.78	275.47	1057.59	99.20
40	INT798	Positive_regulation of Gene_expression of Penk	394	0.70	78.53	203.07	99.20
41	INT7287	Positive_regulation of Transcription of Penk	103	0.70	19.81	50.37	99.20
42	INT4803	Transcription of Penk	435	0.72	59.09	182.4	99.20
43	INT148	Positive_regulation of Gnrhr	182	0.70	47.44	79.64	99.10
44	INT4824	Positive_regulation of Tacr1	169	0.70	66.1	123.46	99.10
45	INT6354	Localization of Gabrg1	321	0.74	41.41	186.74	99.08
46	INT33739	Gene_expression of ITGA2B	25	0.75	8.19	3.6	99.00
47	INT93948	Negative_regulation of Gene_expression of Il12a	48	0.55	27.77	16.87	98.90
48	INT9356	Regulation of pcp	22	0.58	6.26	6.69	98.80
49	INT1652	Regulation of Pomc	387	0.62	61.01	186.51	98.76
50	INT49801	Positive_regulation of SELP	21	0.48	21.34	5.25	98.72
51	INT112380	Positive_regulation of ITGB3	2	0.49	0.84	0.69	98.72
52	INT33133	Positive_regulation of ITGA2B	13	0.67	4.09	1.44	98.72
53	INT7029	Regulation of Pdyn	51	0.61	12.89	40.34	98.64
54	INT85741	Regulation of Negative_regulation of Pdyn	3	0.27	0.7	4.15	98.64
55	INT60691	Gene_expression of Il12a	331	0.78	208.03	75.96	98.60
56	INT117112	Negative_regulation of Mapk1	87	0.56	40.34	31.18	98.50
57	INT7032	Positive_regulation of Pdyn	94	0.66	26.51	58.83	98.46
58	INT6823	Negative_regulation of Pdyn	68	0.58	13.95	46.12	98.46
59	INT62629	Localization of CNR1	35	0.76	11.86	16.3	98.38
60	INT64364	Regulation of GALNT3	3	0.42	1.31	0.39	98.32
61	INT65733	Positive_regulation of Cnr1	125	0.70	40.27	67.33	98.28
62	INT2197	Gene_expression of Gnrh1	184	0.78	40.04	50.57	98.08
63	INT326	Gene_expression of Gnrhr	105	0.76	35.87	34.93	98.08
64	INT6894	Gene_expression of CNR1	168	0.78	74.07	62.84	97.68
65	INT528	Gene_expression of Prl	693	0.78	217.18	192.2	97.44
66	INT797	Regulation of Penk	812	0.62	111.13	542.24	97.40
67	INT109558	Binding of Eae1	9	0.25	10.36	3.16	97.40
68	INT101537	Gene_expression of Vta1	19	0.50	1.88	20.76	97.24
69	INT76620	Gene_expression of Cnr2	93	0.78	34.7	50.14	97.24
70	INT114	Binding of Oprl1	139	0.48	23	103.35	96.72
71	INT155988	Regulation of Localization of ABAT	5	0.24	2.19	6.59	96.68
72	INT19488	Localization of ABAT	56	0.69	21.51	50.56	96.12
73	INT133172	Gene_expression of Il12b	98	0.75	52.16	10.68	95.84
74	INT133174	Positive_regulation of Gene_expression of Il12b	29	0.15	13.04	2.92	95.84
75	INT133169	Positive_regulation of Il12b	25	0.49	13	3.64	95.84
76	INT4439	Positive_regulation of Scd1	1	0.34	0.19	0.39	95.74
77	INT5595	Positive_regulation of Pdyn	223	0.70	48.37	130.14	95.52
78	INT5593	Positive_regulation of Gene_expression of Pdyn	114	0.70	29.1	74.46	95.52
79	INT5597	Gene_expression of Pdyn	433	0.78	62.97	235.47	95.52
80	INT92105	Transcription of Trpv1	47	0.71	27.47	25.01	95.36
81	INT76660	Gene_expression of Trpv1	691	0.78	329.46	386.42	95.08
82	INT2542	Localization of Calca	2008	0.81	518.3	1408.65	94.96
83	INT114751	Gene_expression of Mapk1	137	0.76	60.14	39.98	94.28
84	INT73342	Protein_catabolism of Faah	19	0.97	5.11	8.99	93.92
85	INT88365	Regulation of Faah	18	0.45	6.63	12.54	93.92
86	INT115737	Regulation of Protein_catabolism of Faah	3	0.44	1	1.77	93.92
87	INT12569	Localization of Oprd1	94	0.81	23.81	104.56	93.12
88	INT31393	Positive_regulation of Localization of Oprd1	10	0.66	7.32	21.23	93.12
89	INT95788	Positive_regulation of Positive_regulation of Mapk1	83	0.69	24.75	25.84	93.04
90	INT65731	Gene_expression of Cnr1	234	0.78	63.82	109.34	92.68
91	INT85404	Transcription of Cnr1	12	0.72	3.15	5.73	92.68
92	INT162	Regulation of Prl	794	0.62	165.01	322.24	92.32
93	INT92437	Positive_regulation of Phosphorylation of Mapk1	113	0.70	32.19	40.29	92.32
94	INT16194	Binding of CNR1	82	0.48	20.75	39.59	92.08
95	INT83601	Binding of CNR2	30	0.47	7.79	12.37	92.08
96	INT92434	Phosphorylation of Mapk1	287	0.82	91.65	83.46	91.92
97	INT1321	Localization of Oprl1	18	0.76	1.74	9.56	90.44
98	INT1558	Positive_regulation of Dnahc8	30	0.69	5.78	22.19	90.04
99	INT15898	Positive_regulation of Prkaca	199	0.70	50.89	87.54	89.68
100	INT9381	Positive_regulation of TRPV1	523	0.70	187.4	276.05	89.44
101	INT9748	Negative_regulation of Sysbp1	28	0.35	8.93	3.87	88.16
102	INT7465	Negative_regulation of Mbp	53	0.58	19.12	13.27	87.16
103	INT3915	Gene_expression of SCD	25	0.57	13.94	6	86.72
104	INT1308	Localization of Pomc	457	0.81	66.83	217.5	86.56
105	INT4759	Negative_regulation of Localization of Calca	294	0.59	82.62	226.45	84.60
106	INT4758	Positive_regulation of Localization of Calca	557	0.70	138.55	411.04	84.12
107	INT62630	Positive_regulation of CNR1	86	0.70	40.34	51.51	83.48
108	INT81495	Positive_regulation of CNR2	28	0.67	14.62	14.27	83.36
109	INT147152	Negative_regulation of E2F1	6	0.56	0.89	0.38	81.48
110	INT170308	Gene_expression of Ido1	159	0.75	69.51	15.98	80.80
111	INT170315	Positive_regulation of Gene_expression of Ido1	50	0.67	25.39	6.06	80.80
112	INT73709	Binding of Mastl	11	0.40	3.39	6.76	77.88
113	INT10520	Regulation of Rvm	20	0.24	10.15	20.52	76.24
114	INT52651	Positive_regulation of Prkaca	136	0.67	40.82	99.16	75.00
115	INT34268	Binding of WAS	14	0.47	4.41	8.67	75.00
116	INT50308	Binding of Cnr1	61	0.48	14.41	33.52	75.00
117	INT10442	Negative_regulation of CNR1	47	0.59	20.88	20.2	75.00
118	INT74556	Negative_regulation of Binding of Cnr1	4	0.59	1.13	2.67	75.00
119	INT43507	Gene_expression of Gabbr1	79	0.78	28.53	38.22	74.72
120	INT292606	Phosphorylation of PTPRK	1	0.04	0.12	0.8	74.40
121	INT71946	Negative_regulation of Ass1	7	0.41	1.9	2.68	73.32
122	INT77754	Regulation of Regulation of Rvm	1	0.10	0.33	1.78	69.56
123	INT36237	Gene_expression of Ass1	11	0.24	2.31	4.38	68.84
124	INT9382	Regulation of TRPV1	149	0.62	53.99	77.46	67.44
125	INT49436	Binding of TRPV1	145	0.48	38.35	55.08	67.44
126	INT215380	Positive_regulation of Gene_expression of Cd36	12	0.47	8.51	1.3	66.96
127	INT199084	Gene_expression of Cd36	31	0.53	16.94	1.94	66.96
128	INT1596	Negative_regulation of Oprl1	61	0.57	13.5	38.41	66.88
129	INT239302	Positive_regulation of Gene_expression of Abca1	9	0.32	9.1	1.06	66.24
130	INT190081	Gene_expression of Abca1	21	0.65	18.18	2.45	66.24
131	INT3838	Regulation of FCGR3B	16	0.60	6.67	5.53	64.80
132	INT34263	Positive_regulation of Mastl	8	0.35	1.36	4.35	64.52
133	INT73340	Negative_regulation of Faah	134	0.59	38.67	85.03	64.12
134	INT96969	Positive_regulation of Positive_regulation of CNR1	9	0.48	1.27	7.19	63.88
135	INT155989	Negative_regulation of Localization of ABAT	7	0.38	1.29	6.95	63.36
136	INT84546	Positive_regulation of Ppara	481	0.70	334.21	83.45	62.88
137	INT215378	Protein_catabolism of Ppara	12	0.86	5.12	2.14	62.88
138	INT64202	Positive_regulation of Trpv1	643	0.70	249.66	397.42	61.16
139	INT89657	Gene_expression of Kcnj9	24	0.77	15.15	18.86	58.20
140	INT106793	Positive_regulation of Positive_regulation of Dnahc8	3	0.50	0.58	1.8	57.64
141	INT12608	Regulation of CNR1	62	0.60	24.36	36.02	57.08
142	INT187379	Positive_regulation of Transcription of CYP2B6	1	0.02	0.25	0.63	57.08
143	INT113806	Transcription of CYP2B6	7	0.67	1.75	1.73	56.52
144	INT28420	Gene_expression of Ptgds	59	0.78	31.72	12.67	56.24
145	INT62997	Gene_expression of Kcnj6	17	0.77	2.16	9.44	55.32
146	INT264628	Regulation of GABBR1	3	0.26	1.39	0.62	54.64
147	INT73117	Positive_regulation of DNMT3B	20	0.47	10.31	5.31	54.36
148	INT46336	Regulation of DNMT3B	12	0.53	4.91	1.25	51.24
149	INT7093	Negative_regulation of CYP2B6	146	0.58	37.3	48.39	50.52
150	INT124020	Negative_regulation of Gene_expression of WAS	2	0.06	0.25	0.05	50.00
151	INT310870	Localization of GALNS	1	0.03	0	0.08	49.28
152	INT121531	Negative_regulation of DNMT3B	13	0.36	3.46	3.05	46.56
153	INT14596	Localization of Ptgds	11	0.73	4.41	2.12	46.08
154	INT270028	Positive_regulation of Localization of Ptgds	2	0.45	0.61	0.36	46.08
155	INT19771	Positive_regulation of PAG1	69	0.61	75.61	76.88	43.76
156	INT1556	Regulation of Dnahc8	20	0.61	3.23	14.44	40.48
157	INT18012	Gene_expression of EPO	169	0.78	108.36	13.75	39.44
158	INT3439	Localization of Abat	1017	0.78	112.39	727.06	29.20
159	INT86049	Negative_regulation of D2Mit212	5	0.09	0.94	5	28.68
160	INT261194	Positive_regulation of Gene_expression of Niacr1	3	0.49	1.57	0.38	16.56
161	INT261192	Gene_expression of Niacr1	57	0.67	24.37	1.89	14.80
162	INT74376	Gene_expression of Cnr1	173	0.78	73.43	89.7	5.88
163	INT106565	Negative_regulation of Gene_expression of Cnr1	19	0.59	6.98	9.93	5.88
164	INT173974	Positive_regulation of Localization of Il10	25	0.68	16.81	5.87	5.88
165	INT90792	Localization of Il10	144	0.80	87.88	30.03	5.40
166	INT1912	Gene_expression of Calca	1152	0.78	453.25	739.84	5.00
167	INT58061	Gene_expression of Trpv1	1117	0.78	451.54	637.59	5.00
168	INT2543	Positive_regulation of Calca	787	0.70	331.13	592.08	5.00
169	INT2540	Negative_regulation of Calca	538	0.59	172.11	384.38	5.00
170	INT2909	Positive_regulation of Abat	334	0.70	62.1	256.43	5.00
171	INT9987	Gene_expression of Abat	296	0.78	95.46	226.34	5.00
172	INT2211	Negative_regulation of Abat	267	0.59	66.51	200.98	5.00
173	INT3300	Positive_regulation of Gene_expression of Calca	179	0.70	77.76	144.2	5.00
174	INT60694	Gene_expression of Il10	567	0.78	369.48	143.69	5.00
175	INT14843	Gene_expression of Gabrg1	301	0.77	62.63	139.16	5.00
176	INT48593	Positive_regulation of NOS1	420	0.68	226.15	114.71	5.00
177	INT81417	Gene_expression of PAG1	94	0.58	90.85	92.79	5.00
178	INT14049	Positive_regulation of GRIN1	102	0.70	48.31	71.06	5.00
179	INT18981	Gene_expression of ABAT	78	0.68	38.35	61.36	5.00
180	INT63975	Positive_regulation of Il10	175	0.68	134.13	54.69	5.00
181	INT122041	Binding of Ppara	308	0.48	189.17	51.48	5.00
182	INT12228	Positive_regulation of Gene_expression of Abat	44	0.65	17.51	40.55	5.00
183	INT6417	Negative_regulation of ABAT	49	0.51	19.6	36.81	5.00
184	INT2416	Negative_regulation of MAOA	92	0.59	42.24	36.5	5.00
185	INT73982	Gene_expression of Hmox1	141	0.78	119.43	32.17	5.00
186	INT94658	Positive_regulation of F2rl1	51	0.70	33.65	27.46	5.00
187	INT75418	Negative_regulation of Cnr1	41	0.59	14.65	27.28	5.00
188	INT81496	Gene_expression of CNR2	68	0.75	30.04	24.92	5.00
189	INT151758	Gene_expression of PYCARD	91	0.63	14.54	24.27	5.00
190	INT48536	Positive_regulation of Grm8	46	0.61	14.31	23.56	5.00
191	INT18322	Negative_regulation of Ins1	132	0.58	88.49	22.59	5.00
192	INT84732	Positive_regulation of Hand2	81	0.69	62.07	22	5.00
193	INT90849	Gene_expression of F2rl1	55	0.78	31.31	20.65	5.00
194	INT137767	Gene_expression of Eae1	74	0.34	89.32	20.48	5.00
195	INT26408	Negative_regulation of da	36	0.18	13.46	20.32	5.00
196	INT120446	Positive_regulation of Cnr2	32	0.70	16.3	18.91	5.00
197	INT112017	Regulation of Hand2	77	0.36	62.23	18.04	5.00
198	INT80223	Positive_regulation of Hmox1	128	0.68	77.71	17.64	5.00
199	INT21132	Gene_expression of GABRB3	36	0.33	11.32	17.61	5.00
200	INT63553	Binding of PAG1	14	0.48	12.51	14.76	5.00