P:Duloxetine

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Pain Term
Category Drug
Synonyms None
Pain Specific No
Documents 479
Hot Single Events 145
Hot Interactions 7

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported for Duloxetine. They are ordered first by their pain relevance and then by number of times they were reported for Duloxetine. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT330984 Negative_regulation of CYP2D6 Positive_regulation of Localization of CYP1A2 1 0.46 0 0.62 100.00
2 INT351276 CYP2D6 Regulation of CYP1A2 1 0.12 0 0.63 99.80
3 INT351318 Binding of CYP2C19 and Cyp1a2 1 0.01 0.28 0.22 95.76
4 INT272998 IL33 Negative_regulation of CYP2D6 1 0.04 0 0.25 91.36
5 INT272997 Binding of CYP3A4 and IL33 1 0.03 0 0.25 88.72
6 INT86997 Binding of HIVEP1 and NGF 2 0.03 1.75 1.73 83.08
7 INT154782 Binding of SLC6A4 and Ndst2 1 0.01 0 0.37 82.00
8 INT262370 Binding of GAD1 and GNPTAB 1 0.00 1.36 0 50.00
9 INT321474 Binding of Slc6a2 and Ubqln1 1 0.00 0.8 2.27 5.00
10 INT321477 Binding of Ubqln1 and Flvcr2 1 0.00 0.81 2.26 5.00
11 INT97208 Binding of Gabrg1 and Gabbr1 2 0.07 0.31 1.94 5.00
12 INT262377 Binding of Comt and Fmod 1 0.06 1.47 1.29 5.00
13 INT352269 Binding of Jund and Adora1 1 0.15 1.2 1.25 5.00
14 INT321475 Slc6a2 Positive_regulation of Ubqln1 1 0.00 0.38 1.19 5.00
15 INT321478 Binding of Slc6a2 and Flvcr2 1 0.00 0.41 1.14 5.00
16 INT321476 Binding of Slc6a3 and Slc6a2 1 0.01 0.41 1.14 5.00
17 INT321473 Binding of Slc6a3 and Ubqln1 1 0.00 0.41 1.13 5.00
18 INT321479 Ubqln1 Regulation of Cfp 1 0.00 0.37 0.67 5.00
19 INT311470 Binding of Crp and Il1 1 0.00 2.44 0.63 5.00
20 INT311466 Binding of Acsl1 and Il1 1 0.00 2.46 0.63 5.00
21 INT311467 Binding of Crp and Acsl1 1 0.00 2.31 0.61 5.00
22 INT296169 Binding of Htr4 and Creb1 1 0.49 0.1 0.56 5.00
23 INT352270 Tnf Positive_regulation of GZMA 1 0.13 2.43 0.55 5.00
24 INT352268 Tnf Positive_regulation of Arl6ip6 1 0.02 2.42 0.54 5.00
25 INT315333 Binding of Cflar and Fadd 1 0.01 0.49 0.42 5.00
26 INT296172 Fig4 Positive_regulation of Gene_expression of NOVA2 1 0.04 0 0.22 5.00
27 INT330986 CYP2C9 Positive_regulation of Gene_expression of CYP3A4 1 0.39 0 0.18 5.00
28 INT330985 CYP2C9 Positive_regulation of Gene_expression of CYP2C19 1 0.34 0 0.18 5.00
29 INT295005 Binding of TNFRSF11A and Tnfsf11 3 0.20 2.02 0.09 5.00
30 INT295003 Binding of Tnfrsf11b and Tnfsf11 3 0.22 1.85 0.08 5.00
31 INT321891 Dkk1 Negative_regulation of Wnt2 1 0.12 0.94 0.05 5.00
32 INT295006 Binding of TNFRSF11A and Tnfrsf11b 2 0.10 1.6 0.04 5.00
33 INT321890 Slc3a2 Regulation of Dkk1 1 0.01 0.93 0.04 5.00
34 INT345505 E2f1 Positive_regulation of PMAIP1 1 0.18 0.62 0 5.00
35 INT345489 TP53 Positive_regulation of PMAIP1 1 0.05 0.6 0 5.00
36 INT345485 Binding of MCL1 and BBC3 1 0.01 0.79 0 5.00
37 INT345484 Binding of MCL1 and PMAIP1 1 0.04 0.8 0 5.00
38 INT345486 PMAIP1 Positive_regulation of Localization of CYC1 1 0.18 0.96 0 5.00
39 INT345483 Binding of MYC and PMAIP1 1 0.16 0.63 0 5.00
40 INT345487 HIF1A Positive_regulation of PMAIP1 1 0.27 1.23 0 5.00

Single Events

The table below shows the top 200 pain related interactions that have been reported for Duloxetine. They are ordered first by their pain relevance and then by number of times they were reported in Duloxetine. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT123787 Gene_expression of Bid 25 0.66 16 6.35 100.00
2 INT87822 Binding of Cyp1a2 8 0.47 0.84 2.72 100.00
3 INT331008 Positive_regulation of Localization of CYP1A2 1 0.42 0.06 0.7 100.00
4 INT157282 Localization of CYP1A2 5 0.75 0.54 0.76 100.00
5 INT68899 Binding of CYP1A2 19 0.48 2.33 5.73 100.00
6 INT20332 Positive_regulation of Positive_regulation of CYP1A2 4 0.69 0.68 2.17 100.00
7 INT20331 Positive_regulation of CYP1A2 31 0.69 8.6 5.92 100.00
8 INT57562 Gene_expression of GLA 52 0.77 24.62 6.14 100.00
9 INT156326 Positive_regulation of SMARCB1 20 0.67 8.77 0.97 100.00
10 INT4786 Gene_expression of GHRL 7 0.78 7.94 1.76 100.00
11 INT164259 Gene_expression of H19 8 0.75 27.5 0.97 100.00
12 INT164258 Positive_regulation of Gene_expression of GLA 6 0.47 0.55 0.65 100.00
13 INT164260 Positive_regulation of Gene_expression of H19 2 0.67 4.29 0.43 100.00
14 INT47742 Binding of Flvcr2 26 0.42 3.28 15.87 99.92
15 INT76374 Negative_regulation of Binding of Flvcr2 4 0.35 0.4 2.46 99.92
16 INT50580 Binding of PPIG 39 0.36 11.17 12.34 99.92
17 INT17868 Localization of Cyp1a2 3 0.75 0.05 0.75 99.92
18 INT230829 Localization of Cyp2d4 3 0.63 0.61 5.18 99.92
19 INT4403 Binding of CYP2B6 113 0.48 21.17 33.83 99.92
20 INT95318 Binding of Pain1 17 0.22 21.26 20.14 99.90
21 INT8724 Positive_regulation of Mln 21 0.66 14.12 6.17 99.90
22 INT50404 Negative_regulation of CYP1A2 49 0.59 8.61 17.35 99.88
23 INT71336 Negative_regulation of RNLS 4 0.58 3.42 1.61 99.84
24 INT31780 Binding of DIO2 17 0.36 10.07 10 99.82
25 INT16260 Gene_expression of Bdnf 671 0.78 283.44 339.1 99.80
26 INT55419 Regulation of CYP1A2 19 0.62 5.3 4.75 99.80
27 INT155216 Negative_regulation of Gene_expression of CYP3A4 9 0.56 3.81 2.71 99.80
28 INT47692 Negative_regulation of Positive_regulation of Bdnf 18 0.59 9.64 13.14 99.80
29 INT16253 Positive_regulation of Gene_expression of Bdnf 196 0.70 92.67 113.01 99.78
30 INT39914 Negative_regulation of Cyp1a2 44 0.58 10.04 22 99.76
31 INT15913 Negative_regulation of CYP2D6 174 0.59 22.45 70.91 99.70
32 INT68347 Negative_regulation of Cyp2d4 34 0.58 7.62 18.35 99.70
33 INT97984 Negative_regulation of SLC6A4 45 0.59 15.43 18.09 99.70
34 INT546 Binding of ALB 311 0.48 85.98 60.14 99.62
35 INT16259 Positive_regulation of Bdnf 336 0.70 183.48 209.82 99.62
36 INT17867 Positive_regulation of Cyp1a2 39 0.69 2.58 7.57 99.62
37 INT67855 Negative_regulation of PPIG 64 0.57 17.83 13.54 99.52
38 INT57560 Positive_regulation of GLA 14 0.54 5.01 0.83 99.52
39 INT93354 Negative_regulation of Slc16a11 2 0.51 1.59 2.53 99.46
40 INT199510 Negative_regulation of STIP1 15 0.47 20.99 1.12 99.38
41 INT303913 Regulation of Regulation of CYP2D6 2 0.37 1.09 1.48 99.38
42 INT9852 Positive_regulation of Gpt 563 0.70 364.64 146.82 99.36
43 INT55418 Regulation of CYP2D6 29 0.61 1.83 10.21 99.36
44 INT12129 Gene_expression of CYP3A4 107 0.78 23.11 27.6 99.36
45 INT5398 Positive_regulation of ALPP 178 0.70 110.52 19.18 99.36
46 INT292298 Positive_regulation of GOT2 5 0.45 3.7 1.46 99.36
47 INT67038 Positive_regulation of Positive_regulation of ALPP 5 0.08 2.61 0.77 99.36
48 INT135009 Positive_regulation of BPI 8 0.54 3.8 1.59 99.32
49 INT22210 Gene_expression of CYP1A2 45 0.78 4.95 10.66 99.24
50 INT56870 Gene_expression of CYP2D6 87 0.78 8.83 37.53 99.24
51 INT109686 Gene_expression of Hdlbp 5 0.57 3.07 0.71 99.24
52 INT110551 Negative_regulation of Negative_regulation of CYP2D6 3 0.40 0.25 1.38 99.20
53 INT88184 Gene_expression of ENDO1 5 0.16 0.54 1.69 99.20
54 INT85260 Negative_regulation of ATF7IP 14 0.41 7.08 3.17 99.18
55 INT174844 Binding of Fig4 81 0.41 18.03 12.87 99.18
56 INT223033 Localization of Pain1 2 0.21 1.81 1.97 99.14
57 INT16261 Transcription of Bdnf 101 0.72 49.41 40.64 99.14
58 INT7779 Negative_regulation of Adra2a 47 0.58 9.45 28 99.12
59 INT145097 Negative_regulation of Pain1 16 0.22 19.11 16.82 99.06
60 INT204928 Positive_regulation of ATF7IP 4 0.49 1.69 0.54 99.06
61 INT351280 Negative_regulation of Negative_regulation of CYP1A2 1 0.27 0.53 0.69 99.04
62 INT49212 Negative_regulation of GAD1 23 0.59 22.15 6.54 99.00
63 INT276424 Negative_regulation of IMPACT 4 0.32 2.6 0.72 98.92
64 INT262375 Binding of Fmod 1 0.20 12.37 10.1 98.76
65 INT42979 Positive_regulation of INSRR 47 0.32 12.24 14.38 98.68
66 INT74726 Negative_regulation of Slc6a4 61 0.59 21.01 27.84 98.56
67 INT8905 Gene_expression of EDN1 215 0.78 157.1 34.19 98.54
68 INT250978 Binding of FMOD 4 0.16 12.32 8.75 98.36
69 INT85843 Negative_regulation of BPI 5 0.35 5.13 3.77 98.32
70 INT1221 Regulation of SGCG 65 0.60 24.21 22.94 97.92
71 INT96132 Gene_expression of F10 10 0.58 6.99 1.24 97.76
72 INT711 Positive_regulation of PIK3C2A 83 0.70 76.87 13.18 97.56
73 INT264060 Positive_regulation of TBCEL 1 0.45 0.97 0.5 97.56
74 INT145937 Regulation of PCS 32 0.39 19.25 1.97 97.48
75 INT4420 Positive_regulation of GOT1 103 0.64 88.4 18.38 97.20
76 INT129477 Localization of ATF7IP 4 0.73 1.22 0.39 97.14
77 INT57734 Binding of SLC6A4 36 0.48 11.94 15.42 97.12
78 INT331006 Positive_regulation of Localization of CYP2C9 1 0.34 0.13 1.17 96.76
79 INT145710 Localization of CYP2C9 9 0.75 1.66 2.89 96.76
80 INT331001 Positive_regulation of Localization of CYP2D6 1 0.48 0.23 1.18 96.48
81 INT65135 Binding of CYP2C19 17 0.48 1.82 5.2 96.48
82 INT3038 Gene_expression of INS 1583 0.78 1174.16 107.01 96.42
83 INT318841 Binding of BPI 2 0.29 0.46 0.53 96.28
84 INT303912 Negative_regulation of Localization of ATF7IP 1 0.21 0.16 0.22 95.68
85 INT104760 Localization of MT1A 13 0.44 1.5 4.85 95.56
86 INT899 Gene_expression of F13A1 122 0.70 78.02 16.26 95.52
87 INT95538 Localization of CYP2D6 21 0.81 5.69 4.73 95.36
88 INT108098 Positive_regulation of Itgam 19 0.70 8.09 8.86 95.36
89 INT331002 Negative_regulation of Localization of CYP2D6 1 0.40 0.17 0.6 95.36
90 INT324955 Phosphorylation of Itgam 1 0.37 1.96 2.4 95.36
91 INT66023 Positive_regulation of Gene_expression of Itgam 25 0.64 12.65 16.56 95.36
92 INT5164 Negative_regulation of Ldlr 83 0.58 55.01 7.87 95.36
93 INT66025 Gene_expression of Itgam 61 0.78 31.26 26.08 95.36
94 INT164920 Gene_expression of IL33 22 0.76 13.63 3.16 95.16
95 INT163359 Gene_expression of RFC1 9 0.65 3.34 2.64 95.12
96 INT271160 Negative_regulation of SYNE1 1 0.00 0.67 0.81 95.12
97 INT12398 Regulation of Flvcr2 11 0.39 1.8 9.47 94.76
98 INT351278 Regulation of FMOD 1 0.09 6.45 5.16 94.68
99 INT6437 Binding of YY1 154 0.47 26.3 90.46 94.60
100 INT5116 Gene_expression of IL2 670 0.78 291.13 146.69 94.58
101 INT5056 Gene_expression of IFNG 216 0.78 137.52 74.57 94.58
102 INT4012 Negative_regulation of Psd 23 0.52 14.12 3.81 93.92
103 INT68559 Negative_regulation of Gli3 5 0.37 4.56 4.93 93.76
104 INT244600 Negative_regulation of POSTN 5 0.18 3.12 1.64 93.68
105 INT321199 Binding of POSTN 2 0.31 1.94 0.62 93.68
106 INT345502 Positive_regulation of Binding of POSTN 1 0.07 0.93 0.62 93.68
107 INT105156 Phosphorylation of Gfap 23 0.79 11.85 13.76 93.60
108 INT5843 Positive_regulation of Gfap 184 0.70 108.2 70.21 93.60
109 INT5842 Gene_expression of Gfap 372 0.78 153.71 127.71 93.60
110 INT36751 Gene_expression of ZMYND10 7 0.75 3.92 0.32 93.48
111 INT94833 Gene_expression of FGF1 4 0.53 2.01 0.81 93.40
112 INT154825 Gene_expression of HBXIP 1 0.09 0.2 0.25 93.40
113 INT6176 Positive_regulation of Htr1a 117 0.67 28.23 66.17 93.12
114 INT214 Localization of AVP 370 0.81 208.51 91.09 93.04
115 INT264641 Binding of AES 25 0.42 18.56 6.98 92.88
116 INT77955 Negative_regulation of PCS 55 0.43 39.32 5.76 92.76
117 INT47741 Negative_regulation of Flvcr2 43 0.51 5.72 23.37 92.48
118 INT54924 Gene_expression of RLS 67 0.62 83.2 14.25 92.00
119 INT105157 Positive_regulation of Phosphorylation of Gfap 8 0.67 6.48 6.38 91.84
120 INT144364 Negative_regulation of Lmx1b 5 0.45 3.35 2.12 91.68
121 INT273005 Negative_regulation of IL33 4 0.07 2.4 0.38 91.36
122 INT1118 Gene_expression of C6orf25 73 0.77 47.24 9.1 91.00
123 INT812 Localization of INS 1026 0.81 515.6 145.31 90.42
124 INT242353 Binding of Tcas1 3 0.03 3.31 2.22 89.04
125 INT67620 Negative_regulation of Gene_expression of Bdnf 53 0.59 22.45 28.5 88.48
126 INT94524 Gene_expression of MT1A 6 0.39 1.66 1.75 88.48
127 INT152672 Positive_regulation of Gene_expression of MT1A 2 0.29 0.35 0.68 88.48
128 INT150422 Positive_regulation of Aes 24 0.43 15.63 8 88.20
129 INT151111 Gene_expression of Pain1 33 0.40 33.6 30.73 88.16
130 INT170025 Gene_expression of Fig4 588 0.67 183.27 113.32 88.08
131 INT170033 Positive_regulation of Gene_expression of Fig4 59 0.43 20.99 16.69 88.08
132 INT90910 Phosphorylation of Grin1 150 0.82 68.23 139.24 85.84
133 INT90911 Positive_regulation of Phosphorylation of Grin1 62 0.70 27.45 59.26 85.84
134 INT70572 Gene_expression of Fst 33 0.78 5.22 8.24 84.72
135 INT42980 Gene_expression of GAD1 139 0.69 94.77 45.11 82.96
136 INT17565 Regulation of Gpt 85 0.60 43.64 13.68 82.32
137 INT64386 Binding of Cyp11a1 13 0.46 5.09 3.01 81.96
138 INT156762 Gene_expression of CLC 1 0.29 0.09 0.23 81.84
139 INT156763 Gene_expression of TMEM37 5 0.39 1.48 0.36 81.74
140 INT165737 Localization of RHD 1 0.01 0.08 0.26 81.74
141 INT165738 Localization of TRAPPC1 1 0.04 0.08 0.26 81.74
142 INT204929 Binding of IL33 18 0.08 4.74 0.7 81.68
143 INT202577 Localization of DIO2 9 0.56 1.3 2.97 81.64
144 INT250981 Gene_expression of FMOD 2 0.20 7.3 4.47 80.80
145 INT216731 Localization of HIST1H1B 2 0.19 1 0.59 80.56
146 INT240680 Negative_regulation of Binding of HIST1H1B 2 0.10 0.55 0.41 79.96
147 INT5228 Positive_regulation of Fos 934 0.70 209.8 503.87 79.20
148 INT18012 Gene_expression of EPO 169 0.78 108.36 13.75 79.08
149 INT165736 Gene_expression of TRAPPC1 1 0.03 0.08 0.25 79.08
150 INT31450 Binding of HIST1H1B 20 0.37 10.21 2.84 78.88
151 INT250980 Negative_regulation of FMOD 2 0.14 2.67 2.31 78.64
152 INT108798 Negative_regulation of Positive_regulation of ALPP 9 0.25 4.26 1.46 78.40
153 INT61076 Gene_expression of RHD 9 0.65 3.52 1.39 77.88
154 INT10832 Gene_expression of IL8 1050 0.78 698.72 270 77.84
155 INT155509 Binding of Myo5c 2 0.00 0.85 1.25 77.20
156 INT8640 Positive_regulation of HSD11B1 332 0.67 377.84 22.36 77.04
157 INT11340 Positive_regulation of SLC17A5 120 0.67 113.52 14.5 77.04
158 INT75169 Positive_regulation of GGT2 2 0.67 1.87 0.18 77.04
159 INT15091 Gene_expression of SLC6A4 101 0.78 29.91 53.64 76.28
160 INT27207 Gene_expression of Psd 31 0.73 15.44 2.75 76.16
161 INT264605 Negative_regulation of Binding of Htr3a 1 0.01 1.12 0.64 75.52
162 INT9231 Binding of Htr3a 27 0.47 7.29 13.04 75.12
163 INT64280 Positive_regulation of Ptger1 22 0.67 14.9 7.49 74.72
164 INT261712 Regulation of GABRB3 6 0.09 3.03 3.14 74.36
165 INT49850 Negative_regulation of PDE4A 105 0.58 76.91 26.59 73.44
166 INT181587 Negative_regulation of OPN1SW 12 0.51 4.36 0.89 72.72
167 INT155822 Localization of ADH1A 3 0.78 3.74 0.32 72.60
168 INT5200 Gene_expression of Fos 3083 0.78 894.43 1639.02 72.56
169 INT114741 Binding of PRB1 19 0.36 5.44 1 72.48
170 INT258081 Protein_catabolism of ABAT 5 0.10 2.57 2.86 71.16
171 INT128793 Gene_expression of HBB 16 0.78 10.69 0.42 71.12
172 INT49651 Gene_expression of Creb1 276 0.78 114.77 111.96 69.84
173 INT88617 Positive_regulation of Gene_expression of Creb1 90 0.69 51.69 44.29 69.84
174 INT230828 Regulation of Bpi 1 0.16 0.93 1 68.80
175 INT273000 Localization of IL33 5 0.45 1.77 0.56 68.48
176 INT274741 Positive_regulation of Sez6l 1 0.01 0.07 0.67 68.36
177 INT167521 Regulation of Pain1 11 0.27 10.88 14 65.84
178 INT124930 Positive_regulation of Binding of SLC6A4 1 0.40 0.06 0.33 65.76
179 INT17061 Positive_regulation of POSTN 12 0.42 5.33 2.28 64.56
180 INT123704 Binding of SMARCB1 12 0.36 5.49 0.61 62.48
181 INT4880 Regulation of MME 17 0.61 7.78 8.2 61.28
182 INT96557 Binding of Bdnf 46 0.47 21.74 24.26 61.12
183 INT9269 Regulation of Mt1a 3 0.36 0 1.43 59.64
184 INT264233 Regulation of Mt2 2 0.29 0.21 0.46 59.64
185 INT96504 Negative_regulation of SLC18A2 5 0.36 2.07 4.62 59.32
186 INT345503 Negative_regulation of NEDD8 1 0.18 0.11 0.27 57.80
187 INT10798 Positive_regulation of CYP2D6 24 0.56 5.82 11.31 56.96
188 INT62653 Positive_regulation of CYP2C19 8 0.54 1.23 2.41 56.96
189 INT330997 Regulation of Positive_regulation of CYP2C19 1 0.35 0.3 0.47 56.96
190 INT331000 Regulation of Positive_regulation of CYP2D6 1 0.43 0.3 0.47 56.96
191 INT50403 Negative_regulation of CYP2C19 55 0.59 8.97 17.79 56.44
192 INT6177 Binding of Htr1a 65 0.47 17.65 30.59 56.04
193 INT50579 Binding of CYP3A4 84 0.48 17.52 17.45 54.64
194 INT258135 Gene_expression of CARTPT 3 0.40 5.25 1.88 54.40
195 INT6892 Regulation of Htr1b 9 0.60 1.32 7.24 53.12
196 INT8122 Regulation of Htr1a 39 0.60 8.96 24.89 52.64
197 INT65214 Binding of Slc6a3 54 0.48 4.77 16.79 52.24
198 INT124929 Gene_expression of ZNF74 1 0.04 0 0.2 51.68
199 INT273003 Positive_regulation of IL33 4 0.26 3.27 0.49 51.36
200 INT17564 Gene_expression of Gpt 322 0.75 208.51 60.36 50.00
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