P:Etanercept

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pChart

Pain Term
Category Drug
Synonyms None
Pain Specific No
Documents 760
Hot Single Events 200
Hot Interactions 43

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported for Etanercept. They are ordered first by their pain relevance and then by number of times they were reported for Etanercept. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT238639 Cd86 Negative_regulation of Negative_regulation of Bcl2 1 0.01 0.97 0.46 100.00
2 INT238641 Binding of TNF and Ifx 1 0.07 0.86 0.84 100.00
3 INT238642 Binding of TNF and Ada 1 0.03 0.86 0.84 100.00
4 INT155259 RUNX1 Negative_regulation of Tnf 1 0.00 1.48 0.93 99.92
5 INT131156 Binding of RUNX1 and TNF 2 0.03 3.44 1.42 99.88
6 INT321598 Binding of MLL and TNF 1 0.05 1.07 0.49 99.84
7 INT168256 Binding of MLL and TNFRSF1B 1 0.00 1.2 0.53 99.44
8 INT122163 Binding of TNF and TNFRSF1B 6 0.44 6.06 2.41 99.00
9 INT220116 Tnfrsf1a Negative_regulation of TNF 1 0.06 0.56 0.09 98.76
10 INT119108 Binding of LTBR and TNF 2 0.15 1.47 1.07 98.68
11 INT119107 Negative_regulation of Binding of LTBR and TNF 1 0.17 1.16 0.68 98.68
12 INT119105 Binding of FCGR1A and TNF 1 0.03 1.16 0.67 98.14
13 INT119106 Negative_regulation of Binding of FCGR1A and TNF 1 0.03 1.16 0.67 98.14
14 INT137162 IFNG Positive_regulation of Gene_expression of CXCL9 1 0.45 0.62 0.54 98.02
15 INT137157 TNF Positive_regulation of Gene_expression of CXCL9 1 0.38 0.61 0.54 98.02
16 INT203101 Binding of Aes and Mtx1 2 0.25 0.24 0.88 98.00
17 INT328744 TNF Regulation of Positive_regulation of Mapk14 1 0.02 0.81 0.55 97.56
18 INT134427 Alb Regulation of GGT1 1 0.05 0.7 0.35 97.40
19 INT196586 Negative_regulation of Mapk14 Negative_regulation of TNF 2 0.04 2.02 2.08 96.96
20 INT238638 Gopc Negative_regulation of Gene_expression of Bax 1 0.04 0.85 0.45 96.64
21 INT268236 Binding of TNF and fc 1 0.04 0.2 0.29 95.56
22 INT353010 Binding of GJA8 and TNF 1 0.02 0.24 0.33 95.08
23 INT353009 Binding of GJA8 and VSIG1 1 0.00 0 0.29 95.08
24 INT146412 Tnf Positive_regulation of Gene_expression of Trpv1 2 0.66 5.22 3.22 94.92
25 INT151825 Tnf Positive_regulation of Mapk14 1 0.22 1.72 1.09 94.92
26 INT196585 Mapk14 Regulation of TNF 1 0.02 0.36 0.55 94.72
27 INT306259 HDAC9 Negative_regulation of Gene_expression of TNF 1 0.21 0.89 0.78 92.84
28 INT306258 HDAC4 Negative_regulation of Gene_expression of TNF 1 0.09 0.89 0.78 92.84
29 INT271875 IL1RN Negative_regulation of Binding of IL1B 1 0.01 1.3 1.01 92.80
30 INT284481 Binding of ABCA1 and Ighg1 1 0.00 1.39 0.7 92.72
31 INT173977 Binding of TNF and Ighg1 1 0.03 0.28 0.39 90.36
32 INT252033 Binding of HLA-DQA2 and KLRD1 1 0.00 0.54 0.29 90.36
33 INT172082 TNF Regulation of SFTPA1 1 0.05 0.85 0.5 88.80
34 INT148704 Binding of TNF and TNFRSF1A 5 0.44 3.3 2.09 86.48
35 INT147755 Binding of GNRH1 and TNF 1 0.32 2.37 0.79 83.28
36 INT279266 CADPS Positive_regulation of Regulation of IL1B 1 0.22 1.43 0.28 83.12
37 INT277832 Binding of TNFRSF1B and NPEPPS 1 0.01 1.1 0.88 82.80
38 INT299041 SPARC Regulation of Gene_expression of NPEPPS 1 0.01 0.83 0.42 82.68
39 INT299040 Binding of COL7A1 and SPARC 1 0.02 0.7 0.42 82.68
40 INT277705 SMAP2 Regulation of TNF 1 0.01 1.23 0.25 81.96
41 INT277831 Binding of TNFRSF1A and NPEPPS 1 0.01 1.1 0.87 81.84
42 INT320120 MTX1 Positive_regulation of PTEN 1 0.04 0.09 0.82 81.52
43 INT151826 Tnf Positive_regulation of TNF 1 0.04 3.38 2.51 80.68
44 INT329297 Binding of Cd226 and Aff3 1 0.18 1.54 0.64 79.24
45 INT137168 IFNG Positive_regulation of Gene_expression of CXCR3 1 0.32 0.34 0.32 78.08
46 INT137155 Binding of TLR5 and TLR9 Positive_regulation of Gene_expression of CXCR3 1 0.32 0.34 0.32 78.08
47 INT137154 Binding of TLR7 and TLR9 Positive_regulation of Gene_expression of CXCR3 1 0.34 0.34 0.32 78.08
48 INT137156 Binding of TLR5 and TLR7 Positive_regulation of Gene_expression of CXCR3 1 0.31 0.34 0.32 78.08
49 INT137160 TLR7 Positive_regulation of Gene_expression of CXCR3 1 0.35 0.34 0.32 78.08
50 INT137158 TLR5 Positive_regulation of Gene_expression of CXCR3 1 0.32 0.34 0.32 78.08
51 INT176473 IL10 Positive_regulation of Gene_expression of PECAM1 1 0.05 1.1 0.75 76.60
52 INT267707 Binding of Tnf and ARID1B 2 0.20 8.2 0.54 75.28
53 INT211115 Positive_regulation of Binding of LTBR and TNF 1 0.01 0.31 0.39 75.08
54 INT231796 Binding of Fcr and Sle1 1 0.01 1.62 0.33 74.48
55 INT277089 VEGFA Positive_regulation of Icam1 1 0.02 1.74 0.09 74.00
56 INT277091 VEGFA Positive_regulation of Fas 1 0.03 1.72 0.09 74.00
57 INT277090 VEGFA Positive_regulation of Negative_regulation of Faslg 1 0.02 1.67 0.09 74.00
58 INT351076 IK Positive_regulation of Gene_expression of Ucp3 1 0.00 0.8 0.58 72.24
59 INT137159 Binding of TLR7 and TLR9 1 0.27 0.33 0.29 72.08
60 INT137163 Binding of TLR5 and TLR9 1 0.25 0.33 0.29 72.08
61 INT137169 Binding of TLR5 and TLR7 1 0.25 0.33 0.29 72.08
62 INT353730 Binding of FCGR2A and FCGR3A 1 0.33 0.5 0.41 71.92
63 INT340439 Binding of HLA-DMA and SUGT1 1 0.00 4.1 1.16 70.60
64 INT103796 IL1B Positive_regulation of Gene_expression of SELE 2 0.08 1 0.98 70.48
65 INT176476 TNF Positive_regulation of Gene_expression of SELE 1 0.04 0.57 0.63 70.48
66 INT173112 IL1B Positive_regulation of Gene_expression of VCAM1 2 0.43 1.34 0.76 69.12
67 INT149192 TNF Positive_regulation of Gene_expression of VCAM1 3 0.57 1.4 0.76 69.12
68 INT130721 Binding of IL1B and IL1RN 6 0.05 5.29 2.85 68.96
69 INT285467 Negative_regulation of Binding of IL1B and IL1RN 1 0.05 1.33 0.61 68.96
70 INT133050 TNF Positive_regulation of Gene_expression of ICAM1 3 0.67 1.91 0.94 68.48
71 INT176475 IL1B Positive_regulation of Gene_expression of ICAM1 1 0.02 0.56 0.62 68.48
72 INT172081 TNF Regulation of IFNA1 1 0.03 1.13 0.5 67.24
73 INT172083 TNF Regulation of Regulation of IFNA1 1 0.03 0.91 0.22 66.16
74 INT279361 Binding of TNF and KLF1 4 0.00 3.72 2.19 64.92
75 INT306271 IL1A Positive_regulation of Gene_expression of IL6 1 0.30 0.85 0.8 64.12
76 INT137167 Binding of IFNG and TLR3 1 0.24 0.32 0.27 63.36
77 INT220117 Il6 Positive_regulation of TNF 1 0.01 2.45 0.63 62.64
78 INT176479 IL17A Positive_regulation of Gene_expression of TIMP1 1 0.02 1.33 0.74 61.60
79 INT186393 Binding of TNF and Tnfrsf1a 9 0.37 8.55 1.29 61.52
80 INT186385 Binding of TNF and Tnfrsf1b 4 0.30 3.24 0.42 61.52
81 INT340440 Binding of HLA-B and BTG3 1 0.05 1.57 0.47 54.56
82 INT171974 Binding of Tnfrsf11a and Tnfsf11 14 0.35 13.11 3.11 54.32
83 INT328743 TNF Positive_regulation of Mapk14 1 0.04 1.4 1.21 54.32
84 INT116441 IL1B Positive_regulation of Gene_expression of CCL2 2 0.04 0.62 0.65 54.32
85 INT176470 TNF Positive_regulation of Gene_expression of CCL2 1 0.15 0.62 0.58 54.32
86 INT328742 Il1 Positive_regulation of Mapk14 1 0.01 1.4 1.2 53.68
87 INT172125 Binding of Tnfrsf11b and Tnfrsf11a 2 0.17 2.12 0.39 53.64
88 INT103651 IL1B Positive_regulation of Gene_expression of IL8 6 0.78 1.23 0.98 53.52
89 INT103133 TNF Positive_regulation of Gene_expression of IL8 2 0.48 1.26 0.96 53.52
90 INT308167 Binding of Eln and Tnfrsf1b 1 0.01 0.94 0.71 53.44
91 INT64718 IL1B Positive_regulation of Gene_expression of IL6 15 0.59 9.37 4.48 53.04
92 INT89379 TNF Positive_regulation of Gene_expression of IL6 5 0.50 4.37 1.69 53.04
93 INT176471 TNF Positive_regulation of Gene_expression of IL1B 1 0.02 0.61 0.57 52.56
94 INT317834 Binding of Pstpip1 and Il1 1 0.00 2.03 0.48 51.56
95 INT278379 Binding of Pstpip1 and Mefv 3 0.03 2.02 0.48 51.56
96 INT137170 CXCL9 Positive_regulation of Binding of CXCR3 1 0.44 0.31 0.31 50.64
97 INT317832 Binding of Mefv and Il1 1 0.03 3.89 0.7 47.00
98 INT194578 Binding of HOXA10 and BTG3 1 0.00 0.66 0.24 45.00
99 INT186128 Binding of CD2 and CD58 8 0.10 7.59 2.76 44.64
100 INT306264 Binding of IL1A and MTX1 1 0.09 0.74 0.61 41.76
101 INT71176 Binding of ICAM1 and ITGB2 4 0.21 4.93 1.07 35.88
102 INT294708 CRP Positive_regulation of Gene_expression of VCAM1 2 0.31 1.92 0.56 34.92
103 INT253772 Binding of THBD and Hmgb1 1 0.05 0.95 0.12 34.04
104 INT137166 IL8 Positive_regulation of CXCR2 1 0.24 0.28 0.27 33.68
105 INT306732 Il17a Positive_regulation of Gene_expression of Il2 1 0.09 1.07 0.46 33.52
106 INT306731 Il22 Positive_regulation of Gene_expression of Il2 1 0.12 1.07 0.46 33.52
107 INT267684 Binding of INS and ARID1B 3 0.10 6.08 0.09 33.36
108 INT253769 Binding of Hmgb1 and Il1 1 0.01 0.27 0 33.08
109 INT252633 Binding of TNF and Tnfrsf1b 4 0.05 3.66 1.54 31.20
110 INT333967 Binding of Osm and Sgp158 1 0.00 0.92 0.56 31.20
111 INT275552 Tlr4 Positive_regulation of Gene_expression of Il1 1 0.00 1.28 0.59 30.64
112 INT231349 Il10 Negative_regulation of Gene_expression of TNF 2 0.23 1.82 0.67 30.40
113 INT251580 Il13 Negative_regulation of Gene_expression of TNF 1 0.08 0.96 0.27 30.40
114 INT251567 Il4 Negative_regulation of Gene_expression of Il10 1 0.01 0.96 0.27 30.40
115 INT251581 Il4 Negative_regulation of Gene_expression of TNF 1 0.05 0.95 0.26 30.40
116 INT334009 Binding of CCL25 and CCR9 1 0.40 0.96 0.4 30.24
117 INT334025 Binding of CCR9 and Ccl25 1 0.40 0.96 0.4 29.84
118 INT196584 Binding of Mapk14 and NeuN 1 0.02 0.39 0.27 29.36
119 INT252634 Binding of TNF and Tnfrsf1a 4 0.02 2.4 0.46 28.00
120 INT293708 Binding of TNF and Trap1 1 0.00 0.94 0.27 27.44
121 INT308173 Binding of DRG1 and Tnfrsf1b 1 0.01 1.64 1.1 26.88
122 INT340438 Binding of HLA-DMA and MRAP 1 0.02 1.69 0.43 25.52
123 INT223157 Abat Negative_regulation of Localization of Il6 1 0.05 1.13 1.1 24.24
124 INT223154 Negative_regulation of Mapk14 Negative_regulation of Localization of Il6 1 0.19 1.13 1.11 24.04
125 INT183387 Il6 Positive_regulation of Gene_expression of Il10 2 0.19 1.8 0.63 21.68
126 INT317831 Binding of Mefv and Nlrx1 1 0.00 1.77 0.2 20.40
127 INT182043 Binding of Gpi1 and IgG 1 0.13 0.94 0.25 17.72
128 INT171976 Il18 Positive_regulation of Gene_expression of IFNA1 1 0.01 1.37 0.64 16.40
129 INT188432 Negative_regulation of Binding of ABCA1 and IL6 1 0.02 0.47 0.05 14.00
130 INT188431 Binding of ABCA1 and IL6 1 0.02 0.47 0.05 14.00
131 INT254243 Binding of HOMER1 and MRI1 1 0.03 1.99 1.57 11.88
132 INT295472 IRF6 Positive_regulation of Gene_expression of TNF 2 0.16 0.95 0.27 10.40
133 INT211129 Negative_regulation of Binding of P4HB and TNF 1 0.10 0.97 0.9 9.92
134 INT194621 TNF Positive_regulation of Gene_expression of Klrk1 1 0.05 0.5 0.32 9.68
135 INT194614 Il15 Positive_regulation of Gene_expression of Klrk1 1 0.04 0.5 0.32 9.68
136 INT211128 Binding of P4HB and TNF 1 0.09 0.97 0.9 9.40
137 INT306745 Binding of Il12a and IL23A 1 0.10 3.25 1.56 8.24
138 INT306255 IRF6 Positive_regulation of TFAM 1 0.01 0 0.07 6.56
139 INT306260 TLR4 Positive_regulation of TFAM 1 0.01 0 0.07 6.56
140 INT277791 Binding of Icam1 and Itgal 1 0.03 0.37 0.17 6.12
141 INT149117 Binding of CD80 and CTLA4 31 0.52 12.7 7.73 5.00
142 INT155484 Binding of CD86 and CTLA4 15 0.52 8.85 6.09 5.00
143 INT176477 Binding of CXCR3 and CXCL10 14 0.25 10.61 5.87 5.00
144 INT194647 Binding of CD28 and CD80 15 0.40 4.9 3.22 5.00
145 INT186126 Binding of CD28 and CTLA4 9 0.52 4.13 3.12 5.00
146 INT175329 Binding of ICAM1 and ITGAL 14 0.18 10.06 2.81 5.00
147 INT299783 Binding of Cd28 and Cd80 7 0.14 6.49 2.49 5.00
148 INT115367 Binding of IL6 and IL6R 12 0.07 8.16 2.36 5.00
149 INT126717 Binding of Il6 and Il6st 3 0.21 3.35 2.22 5.00
150 INT194646 Binding of CD28 and CD86 7 0.40 2.69 2.21 5.00
151 INT86179 TNF Positive_regulation of Localization of IL6 5 0.35 1.66 2.17 5.00
152 INT239037 Binding of Cd28 and Cd86 9 0.16 3.69 2.14 5.00
153 INT157767 Binding of TLR4 and LY96 8 0.54 4.05 1.95 5.00
154 INT279359 Binding of ADA and TNF 1 0.20 2.61 1.91 5.00
155 INT95405 Trib3 Positive_regulation of Phosphorylation of Ephb1 3 0.08 1.33 1.89 5.00
156 INT201940 Binding of IL8 and CXCL10 2 0.28 2.46 1.86 5.00
157 INT194863 Binding of IL1R1 and IL1RN 5 0.09 2.23 1.64 5.00
158 INT254205 Binding of Myd88 and Tlr4 12 0.19 3.17 1.54 5.00
159 INT126718 Binding of Il6 and Il6r 3 0.09 2.33 1.49 5.00
160 INT222185 Binding of Ccr1 and Ccl3 4 0.23 2.7 1.47 5.00
161 INT285569 TNF Negative_regulation of Gene_expression of Il6 1 0.03 2.83 1.46 5.00
162 INT223156 Il6 Regulation of A2m 1 0.11 2.79 1.39 5.00
163 INT218309 Binding of CRP and IL6 3 0.23 4.78 1.36 5.00
164 INT326194 Bdnf Regulation of Slc12a5 1 0.05 0.85 1.35 5.00
165 INT254210 Binding of Cxcr2 and Ccl2 1 0.08 2.39 1.25 5.00
166 INT186355 Il23a Positive_regulation of Gene_expression of Il17a 4 0.12 3 1.24 5.00
167 INT197092 TNF Regulation of VEGFA 4 0.21 2.78 1.22 5.00
168 INT194619 Il15 Positive_regulation of Gene_expression of TNF 1 0.24 2.23 1.2 5.00
169 INT308172 Rvm Positive_regulation of Phosphorylation of GRIN1 1 0.50 0.68 1.14 5.00
170 INT260810 Binding of CXCL10 and CCL2 1 0.10 1.37 1.12 5.00
171 INT333966 Binding of Il6r and Il6st 1 0.01 1.74 1.1 5.00
172 INT186125 Negative_regulation of Binding of CD2 and CD58 3 0.12 3.04 1.06 5.00
173 INT353741 Binding of IGHE and Aia1 1 0.00 1.16 1.06 5.00
174 INT176474 Binding of CXCR3 and CXCL9 3 0.22 1.9 1.05 5.00
175 INT266742 GOPC Regulation of Positive_regulation of ACR 1 0.02 0.36 1.05 5.00
176 INT181450 Binding of Ccr5 and Ccl3 4 0.18 2.19 1.03 5.00
177 INT206074 Binding of IL6 and IL6ST 7 0.32 3.79 1.01 5.00
178 INT228498 Il10 Negative_regulation of Hand1 1 0.03 1.4 0.99 5.00
179 INT228496 Il4 Negative_regulation of Hand1 1 0.02 1.4 0.99 5.00
180 INT228495 Il13 Negative_regulation of Hand1 1 0.01 1.4 0.98 5.00
181 INT317836 Binding of Fibp and Pycard 1 0.00 2.68 0.98 5.00
182 INT187111 TIMP2 Regulation of MMP9 1 0.23 1.47 0.97 5.00
183 INT308169 Negative_regulation of Mapk14 Negative_regulation of Ltp 1 0.01 0.79 0.95 5.00
184 INT285561 Il23a Positive_regulation of Gene_expression of Il22 2 0.06 2.45 0.93 5.00
185 INT302828 Mapkapk5 Positive_regulation of Mapk1 1 0.07 1.38 0.91 5.00
186 INT254242 TNF Positive_regulation of Gene_expression of DKK1 1 0.14 1.24 0.91 5.00
187 INT221386 Tlr4 Positive_regulation of Gene_expression of IL8 6 0.14 3.53 0.9 5.00
188 INT183269 Binding of CEBPB and CPOX 1 0.07 1.61 0.89 5.00
189 INT249347 Binding of FOS and JUN 4 0.19 6.15 0.89 5.00
190 INT166983 Binding of HLA-B and HSPG2 4 0.08 4.66 0.88 5.00
191 INT196578 Ephb1 Positive_regulation of Phosphorylation of Mapk9 1 0.13 0.5 0.85 5.00
192 INT196576 Trib3 Positive_regulation of Phosphorylation of Mapk9 1 0.02 0.5 0.85 5.00
193 INT340437 Binding of SERPINH1 and HLA-DRB4 1 0.00 2.26 0.84 5.00
194 INT187290 Binding of HEY1 and Gtf3a 1 0.00 6.18 0.83 5.00
195 INT189671 DAG1 Positive_regulation of PRKCA 3 0.12 0.71 0.82 5.00
196 INT302831 Binding of Creb1 and Mapkapk5 1 0.07 1.3 0.79 5.00
197 INT196577 Negative_regulation of Mapk14 Negative_regulation of Il6 1 0.13 0.45 0.78 5.00
198 INT196574 Negative_regulation of Mapk14 Negative_regulation of Gene_expression of Il6 1 0.13 0.45 0.78 5.00
199 INT184116 Il10 Positive_regulation of Stat3 2 0.18 1.15 0.77 5.00
200 INT196575 Negative_regulation of Mapk14 Negative_regulation of Gene_expression of Il1a 1 0.04 0.44 0.77 5.00

Single Events

The table below shows the top 200 pain related interactions that have been reported for Etanercept. They are ordered first by their pain relevance and then by number of times they were reported in Etanercept. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT6481 Binding of TNF 624 0.48 510.2 214.82 100.00
2 INT6483 Gene_expression of TNF 3152 0.78 2515.62 929.82 100.00
3 INT5059 Positive_regulation of TNF 1050 0.70 896.51 322.81 100.00
4 INT6852 Localization of TNF 883 0.81 705.95 270.84 100.00
5 INT145594 Gene_expression of Mtx1 64 0.57 35.33 30.35 100.00
6 INT132161 Gene_expression of MTX1 48 0.58 26.55 32.32 100.00
7 INT22112 Positive_regulation of Localization of TNF 164 0.70 115.66 52.18 100.00
8 INT3545 Positive_regulation of Mtx1 27 0.42 11.97 14.83 100.00
9 INT9236 Regulation of Gene_expression of TNF 204 0.62 162.66 72.99 100.00
10 INT6478 Negative_regulation of Binding of TNF 36 0.58 30.42 13.31 100.00
11 INT211113 Binding of Etn1 1 0.01 1.36 1.82 100.00
12 INT22285 Negative_regulation of Mtx1 16 0.49 7.84 8.98 100.00
13 INT56160 Binding of Ifx 14 0.36 11.39 5.74 100.00
14 INT13354 Transcription of TNF 108 0.72 85.81 42.32 100.00
15 INT232414 Negative_regulation of Ifx 6 0.42 3.28 2.26 100.00
16 INT128695 Regulation of Gene_expression of Mapk14 14 0.44 11.49 7.14 100.00
17 INT288676 Negative_regulation of CREM 3 0.18 1.34 0.96 100.00
18 INT5969 Gene_expression of Il1a 221 0.75 96.31 71.38 100.00
19 INT170444 Binding of Gopc 172 0.39 45.05 20.71 100.00
20 INT196393 Negative_regulation of Cd86 9 0.22 4.24 1.17 100.00
21 INT1710 Gene_expression of Etn1 13 0.37 3.85 1.39 100.00
22 INT44015 Binding of Cd86 16 0.31 5.92 3.58 100.00
23 INT171472 Binding of Mapk14 10 0.36 6.79 4.83 100.00
24 INT211112 Positive_regulation of Etn1 3 0.28 4.28 0.92 100.00
25 INT72532 Regulation of Gene_expression of Il1a 13 0.54 4.91 6.71 100.00
26 INT340441 Positive_regulation of Binding of MTX1 1 0.17 1.7 0.72 100.00
27 INT103554 Positive_regulation of MTX1 19 0.45 11.23 10 100.00
28 INT61452 Gene_expression of IL1RAP 15 0.58 7.21 5.09 100.00
29 INT67796 Negative_regulation of CTLA4 13 0.39 8.36 2.39 100.00
30 INT125530 Negative_regulation of Gene_expression of IL1RAP 1 0.12 1.13 0.57 100.00
31 INT125531 Negative_regulation of IL1RAP 1 0.12 1.13 0.57 100.00
32 INT85421 Regulation of LY75-CD302 1 0.03 0.86 0.37 100.00
33 INT289973 Negative_regulation of Gene_expression of MIP 2 0.41 2.69 1.15 99.98
34 INT77652 Negative_regulation of Gene_expression of IL8 99 0.59 67.57 30.21 99.98
35 INT125411 Negative_regulation of Phosphorylation of Mapk14 31 0.57 18.55 19.98 99.98
36 INT228469 Negative_regulation of Il17a 19 0.54 18.76 6.43 99.98
37 INT285482 Negative_regulation of Il22 3 0.30 3.02 1.37 99.98
38 INT306729 Negative_regulation of Ccl20 1 0.05 1.01 0.57 99.98
39 INT306725 Negative_regulation of Defb4 1 0.01 1.02 0.57 99.98
40 INT5235 Negative_regulation of TNF 924 0.59 772.91 331.98 99.96
41 INT78713 Negative_regulation of Ngfr 9 0.54 7.07 6.73 99.96
42 INT9660 Regulation of TNF 363 0.62 312.94 139.99 99.92
43 INT58400 Negative_regulation of Tnf 182 0.59 129.97 71 99.92
44 INT6488 Gene_expression of Tnf 484 0.78 339.61 191.58 99.92
45 INT6489 Positive_regulation of Gene_expression of Tnf 140 0.70 92.31 67.85 99.92
46 INT55670 Negative_regulation of Gene_expression of Tnf 83 0.59 57.16 46.33 99.92
47 INT60528 Negative_regulation of TNFRSF1A 6 0.42 4.86 1.45 99.92
48 INT133568 Regulation of TNFRSF1B 1 0.01 0.54 0.37 99.92
49 INT6482 Positive_regulation of Gene_expression of TNF 659 0.70 569.88 210 99.88
50 INT115370 Gene_expression of PSIP1 22 0.65 9.45 5.68 99.88
51 INT115369 Positive_regulation of Gene_expression of PSIP1 4 0.49 4.92 1.88 99.88
52 INT177998 Binding of RUNX1 7 0.35 7.12 2.08 99.88
53 INT151823 Binding of Tnfrsf1b 19 0.42 17.92 7.31 99.86
54 INT66347 Gene_expression of MLL 29 0.65 14.82 3.18 99.86
55 INT13353 Positive_regulation of Tnf 332 0.70 248.75 148.1 99.84
56 INT10166 Localization of Tnf 237 0.81 153.95 88.64 99.84
57 INT5609 Regulation of Ifx 6 0.60 5.73 3.5 99.84
58 INT211132 Positive_regulation of Gene_expression of MTX1 4 0.23 2.71 2.94 99.84
59 INT10832 Gene_expression of IL8 1050 0.78 698.72 270 99.82
60 INT10837 Positive_regulation of Gene_expression of IL8 294 0.70 190.08 70.34 99.82
61 INT83292 Gene_expression of MIP 35 0.75 25.22 10.14 99.82
62 INT112971 Positive_regulation of Gene_expression of MIP 3 0.49 5.24 1.82 99.82
63 INT43723 Regulation of Vegfa 9 0.34 4.96 2.28 99.82
64 INT182320 Binding of MTX1 14 0.18 8.5 7.65 99.80
65 INT50212 Gene_expression of Ifx 33 0.75 32.17 7.26 99.80
66 INT5780 Regulation of Gene_expression of Calca 90 0.62 59.52 85.03 99.78
67 INT10173 Binding of Tnf 45 0.48 35.6 14.32 99.76
68 INT8483 Positive_regulation of Positive_regulation of TNF 73 0.67 60.35 22.03 99.74
69 INT277084 Negative_regulation of Gene_expression of Olfr148 1 0.06 1.91 0.38 99.74
70 INT99070 Gene_expression of Mapk14 147 0.78 103.99 79.59 99.74
71 INT277052 Negative_regulation of Abpd 1 0.42 0.91 0.68 99.74
72 INT117598 Regulation of ACR 118 0.26 41.25 48.01 99.72
73 INT19609 Positive_regulation of PSIP1 4 0.49 4.54 2.04 99.72
74 INT163134 Gene_expression of ACR 78 0.65 30.39 38.48 99.70
75 INT97701 Phosphorylation of Mapk14 191 0.82 115.33 100.46 99.68
76 INT238636 Regulation of Ada 2 0.15 1.12 1.06 99.66
77 INT76149 Gene_expression of Das 18 0.37 6.55 3.92 99.64
78 INT1912 Gene_expression of Calca 1152 0.78 453.25 739.84 99.64
79 INT170646 Negative_regulation of Fig4 213 0.37 81.29 46.92 99.62
80 INT104954 Negative_regulation of Positive_regulation of Mapk14 29 0.58 17.71 13.31 99.60
81 INT238637 Binding of Ada 2 0.26 1.01 0.94 99.58
82 INT15514 Negative_regulation of Crp 275 0.59 194.6 64.86 99.56
83 INT80222 Negative_regulation of Bcl2 82 0.58 69.16 13.18 99.52
84 INT15516 Gene_expression of Crp 711 0.77 615.33 173.09 99.50
85 INT9852 Positive_regulation of Gpt 563 0.70 364.64 146.82 99.44
86 INT55698 Regulation of Binding of TNF 13 0.44 8.98 4.74 99.44
87 INT166203 Positive_regulation of Cia1 62 0.43 75.94 31.37 99.44
88 INT168257 Binding of MLL 4 0.02 4.25 0.53 99.44
89 INT204549 Negative_regulation of Positive_regulation of Cia1 5 0.16 7.49 3.72 99.44
90 INT15515 Positive_regulation of Crp 700 0.70 604.24 150.15 99.40
91 INT823 Negative_regulation of ESR1 144 0.58 63.72 22.52 99.40
92 INT151525 Gene_expression of Olfr148 7 0.67 8.5 0.74 99.40
93 INT109724 Phosphorylation of FSCN1 5 0.07 3.15 8.82 99.40
94 INT107399 Positive_regulation of Das 7 0.28 1.55 2.74 99.40
95 INT110023 Negative_regulation of Mapk14 127 0.59 84.27 45.42 99.40
96 INT56450 Negative_regulation of Gene_expression of Icam1 33 0.52 27.21 10.15 99.38
97 INT90675 Negative_regulation of Gene_expression of Nos3 15 0.46 11.11 2.7 99.38
98 INT97019 Negative_regulation of Binding of TNFRSF11A 4 0.17 1.8 1.89 99.38
99 INT122165 Binding of TNFRSF1B 8 0.28 7.46 4.87 99.36
100 INT271886 Transcription of TNFRSF1B 1 0.51 1.76 1.23 99.36
101 INT82737 Regulation of Hmox2 7 0.14 4.6 2.44 99.36
102 INT6855 Binding of NCOR2 71 0.41 15.64 28.96 99.30
103 INT172084 Positive_regulation of Binding of TNF 21 0.50 15.31 6.06 99.20
104 INT8640 Positive_regulation of HSD11B1 332 0.67 377.84 22.36 99.18
105 INT9837 Negative_regulation of Rf 12 0.11 8.41 4.55 99.16
106 INT67822 Binding of SERPINH1 17 0.36 19.05 7.24 99.16
107 INT60745 Gene_expression of Ltbr 10 0.61 7.86 3.21 99.16
108 INT52732 Negative_regulation of CRP 169 0.59 138.47 40.33 99.12
109 INT46695 Positive_regulation of TNC 28 0.67 17.06 12.04 99.12
110 INT48406 Gene_expression of Icam1 277 0.78 238.28 81.71 99.06
111 INT51461 Gene_expression of Itgb2 7 0.75 5.48 2.2 99.04
112 INT100909 Negative_regulation of Gene_expression of Itgb2 2 0.41 1.79 1.22 99.04
113 INT2249 Negative_regulation of Binding of HLA-B 5 0.54 6.82 2.94 99.04
114 INT94952 Positive_regulation of Mapk14 305 0.70 197.83 186.61 98.96
115 INT27230 Gene_expression of LTBR 10 0.75 8.57 2.34 98.96
116 INT9158 Gene_expression of Tnf 722 0.78 522.01 277.68 98.96
117 INT52800 Negative_regulation of Gene_expression of Tnf 142 0.59 92.27 55.47 98.96
118 INT294551 Gene_expression of 5830403L16Rik 1 0.65 1.74 1.72 98.92
119 INT92354 Localization of ESR1 77 0.75 33.04 15.51 98.92
120 INT83199 Gene_expression of Nos3 193 0.78 100.72 51.57 98.92
121 INT2006 Gene_expression of fc 104 0.34 64.91 19.08 98.90
122 INT66029 Negative_regulation of Tnf 100 0.59 84.28 48.16 98.88
123 INT9235 Negative_regulation of Gene_expression of TNF 346 0.59 252.98 118.61 98.88
124 INT346112 Negative_regulation of Negative_regulation of IgG 1 0.01 0.05 0.63 98.88
125 INT323912 Regulation of ARC 1 0.01 1.06 1.78 98.88
126 INT346639 Negative_regulation of Gene_expression of TNFRSF1B 1 0.23 1.14 0.35 98.88
127 INT54044 Negative_regulation of EDA 7 0.42 2.54 1.14 98.86
128 INT6476 Gene_expression of TNFRSF1B 21 0.67 18.22 5.25 98.84
129 INT9220 Gene_expression of Ighg1 125 0.77 85.74 15.92 98.84
130 INT151527 Positive_regulation of Olfr148 4 0.40 3.76 0.35 98.84
131 INT87193 Gene_expression of Tnfrsf1b 30 0.58 29.4 9.22 98.84
132 INT5058 Positive_regulation of IFNA1 356 0.70 245.75 60.52 98.80
133 INT23257 Regulation of CRP 127 0.62 100.05 21.87 98.80
134 INT117080 Localization of Csrp1 6 0.42 7.23 3.09 98.76
135 INT11907 Regulation of LTBR 2 0.41 1.7 0.61 98.76
136 INT87687 Positive_regulation of Trpv1 409 0.70 210.24 257.59 98.76
137 INT106264 Negative_regulation of Gene_expression of Vcam1 13 0.53 10.47 3.55 98.76
138 INT129755 Gene_expression of TBA 5 0.52 1.59 0.29 98.74
139 INT2729 Binding of LTBR 4 0.37 4.23 1.71 98.68
140 INT140503 Negative_regulation of Gene_expression of Mmp3 7 0.44 5.93 6.08 98.66
141 INT272892 Gene_expression of Bhr1 2 0.25 2.1 0.67 98.66
142 INT66025 Gene_expression of Itgam 61 0.78 31.26 26.08 98.64
143 INT66024 Negative_regulation of Gene_expression of Itgam 9 0.59 5.5 4.38 98.64
144 INT183979 Localization of PSIP1 2 0.73 1.37 0.59 98.64
145 INT67333 Negative_regulation of ITGB2 10 0.41 6.92 3.06 98.58
146 INT1878 Binding of HLA-B 440 0.48 321.16 127.36 98.56
147 INT19399 Gene_expression of Rf 43 0.36 33.39 13.53 98.56
148 INT89404 Regulation of Negative_regulation of TNF 30 0.45 24.47 12.71 98.52
149 INT11346 Binding of Mtx1 39 0.41 24.88 21.21 98.48
150 INT15687 Regulation of ESR1 91 0.60 40.42 7.95 98.48
151 INT93717 Gene_expression of Mmp3 85 0.78 33.95 24.89 98.48
152 INT195226 Positive_regulation of ACR 23 0.26 7.85 12.62 98.44
153 INT100423 Gene_expression of Bax 141 0.75 98.43 24.48 98.44
154 INT299751 Positive_regulation of Positive_regulation of ACR 1 0.05 0.78 1.59 98.44
155 INT145266 Gene_expression of IL17A 154 0.75 109.83 45.33 98.44
156 INT55879 Gene_expression of CCL2 421 0.78 240.74 166.02 98.40
157 INT24232 Localization of Mtx1 24 0.65 8.06 7.99 98.36
158 INT38814 Positive_regulation of Aspt1 9 0.63 6.89 3.06 98.36
159 INT122290 Regulation of Gene_expression of Vcam1 9 0.42 7.15 2.26 98.28
160 INT17612 Gene_expression of CRP 676 0.78 580.61 119.03 98.24
161 INT88935 Positive_regulation of SPP1 36 0.70 31.07 5.49 98.24
162 INT115987 Positive_regulation of SPARC 4 0.44 1.52 0.99 98.24
163 INT39170 Gene_expression of TSPO 76 0.78 24.11 8.05 98.22
164 INT77307 Gene_expression of Bcl2 399 0.77 319.77 38 98.20
165 INT232656 Localization of MLL 2 0.05 2.33 0.29 98.16
166 INT31940 Binding of FCGR1A 6 0.35 2.16 3.1 98.14
167 INT93016 Binding of TNFRSF11A 29 0.47 19.67 4.17 98.14
168 INT613 Gene_expression of Alb 268 0.78 149.84 42.78 98.12
169 INT8106 Gene_expression of GGT1 31 0.75 18.65 6.1 98.12
170 INT18192 Regulation of Gene_expression of Alb 16 0.44 9.38 3.57 98.12
171 INT133567 Regulation of IL18 11 0.50 9.54 2.31 98.08
172 INT133566 Regulation of Il15 2 0.60 1.44 1.22 98.08
173 INT133569 Regulation of IL23A 2 0.12 0.86 0.41 98.08
174 INT725 Negative_regulation of IgG 62 0.41 37.21 8.16 98.04
175 INT168263 Gene_expression of IL23A 57 0.58 47.1 17.67 98.04
176 INT137181 Gene_expression of CXCL9 25 0.65 13.09 9.56 98.02
177 INT137175 Positive_regulation of Gene_expression of CXCL9 1 0.47 1.32 1.07 98.02
178 INT49105 Gene_expression of Vcam1 157 0.78 157.27 43.01 97.94
179 INT9238 Gene_expression of IL6 1575 0.78 1135.66 424.22 97.92
180 INT9210 Regulation of IL6 166 0.62 125.61 49.95 97.92
181 INT34869 Negative_regulation of PTGS2 778 0.59 366.76 319.85 97.88
182 INT10795 Positive_regulation of CD59 9 0.36 2.11 2.52 97.88
183 INT68202 Gene_expression of ADA 26 0.68 23.15 5.18 97.88
184 INT48408 Gene_expression of ICAM1 494 0.78 340.08 88.6 97.84
185 INT49196 Gene_expression of SELE 105 0.78 107.29 22.92 97.84
186 INT131782 Regulation of Positive_regulation of Mapk14 7 0.43 2.68 4.02 97.80
187 INT93626 Gene_expression of Fasl 118 0.75 115.24 25.11 97.76
188 INT177467 Negative_regulation of MTRF1 22 0.05 11.84 5.57 97.76
189 INT294548 Positive_regulation of Positive_regulation of 5830403L16Rik 1 0.49 0.39 0.52 97.64
190 INT294546 Positive_regulation of 5830403L16Rik 1 0.49 0.39 0.49 97.64
191 INT134339 Positive_regulation of CD55 8 0.56 3.19 0.54 97.52
192 INT99942 Positive_regulation of Fasl 37 0.68 32.61 6.92 97.48
193 INT15511 Gene_expression of Tnfrsf1a 84 0.76 63.3 24.03 97.44
194 INT138157 Regulation of Mmp3 12 0.54 6.12 5.36 97.42
195 INT154359 Regulation of Mmp3 1 0.49 0.94 0.59 97.42
196 INT120811 Gene_expression of Gopc 1174 0.59 428.49 150.55 97.40
197 INT94118 Localization of Tnfrsf1a 9 0.72 7.24 5.81 97.40
198 INT5307 Regulation of Tnf 87 0.62 78.71 43.4 97.36
199 INT55671 Gene_expression of Ik 151 0.27 80.1 48.49 97.36
200 INT57057 Gene_expression of APC 131 0.78 122.24 8.7 97.36
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