P:Face pain

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Pain Term
Category Pain type
Synonyms Atypical Facial Pain, Craniofacial Pain, Myofacial Pain, Orofacial Pain, Pain Craniofacial, Pain Face, Pain Facial, Pain Myofacial, Pain Neuralgic Facial, Pain Orofacial, Pain Referred Facial, Referred Facial Pain, Trigeminal Neuralgia
Pain Specific Yes
Documents 1304
Hot Single Events 81
Hot Interactions 1

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported for Face pain. They are ordered first by their pain relevance and then by number of times they were reported for Face pain. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT138273 Gtf3a Regulation of Paf 1 0.39 0.26 0.34 97.92
2 INT317184 BMS1 Regulation of Gene_expression of NAV1 1 0.03 1.94 1.62 75.32
3 INT252869 Binding of Trpv1 and Phax 2 0.01 0.18 0.6 50.00
4 INT292531 Il10 Negative_regulation of Positive_regulation of Mapk14 1 0.15 1.13 1.06 5.00
5 INT292530 Il10 Negative_regulation of Localization of Il1a 1 0.06 1.09 0.97 5.00
6 INT265649 TBK1 Negative_regulation of COMT 1 0.01 0.61 0.94 5.00
7 INT265651 Binding of ITGAL and MYCN 1 0.00 0.46 0.62 5.00
8 INT265652 Binding of CISH and MYCN 1 0.00 0.28 0.28 5.00
9 INT229601 Binding of DIS3 and RLS 1 0.14 2.19 0.06 5.00
10 INT229602 Binding of ETFA and DIS3 1 0.08 1.12 0 5.00

Single Events

The table below shows the top 200 pain related interactions that have been reported for Face pain. They are ordered first by their pain relevance and then by number of times they were reported in Face pain. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT39357 Binding of Afp 5 0.48 3.58 0.85 100.00
2 INT163157 Binding of BMS1 3 0.42 3.6 1.77 100.00
3 INT168681 Gene_expression of BMS1 5 0.37 2.7 1.62 100.00
4 INT5039 Positive_regulation of Gal 67 0.68 27.97 37.36 99.98
5 INT13501 Binding of Drd2 65 0.48 23.76 35.6 99.84
6 INT265662 Negative_regulation of Binding of COMT 4 0.37 1.29 2.42 99.80
7 INT118156 Binding of Prkcz 2 0.08 2.68 2.89 99.76
8 INT5374 Gene_expression of Esr1 412 0.77 263.89 67.34 99.72
9 INT18357 Gene_expression of TRPV1 825 0.78 307.11 382.81 99.60
10 INT131413 Positive_regulation of Gene_expression of NAV1 35 0.70 17.5 36.83 99.56
11 INT135629 Binding of COMT 33 0.48 16.68 19.37 99.52
12 INT202257 Localization of COMT 7 0.75 2.13 2.65 99.52
13 INT160666 Binding of Prdm6 2 0.31 0.73 0.35 99.42
14 INT76660 Gene_expression of Trpv1 691 0.78 329.46 386.42 99.40
15 INT46460 Gene_expression of NAV1 288 0.78 135.51 305.75 99.32
16 INT81087 Gene_expression of ASIC3 30 0.75 13.62 16.54 99.16
17 INT9556 Negative_regulation of NAV1 47 0.59 28.49 49.33 99.12
18 INT48883 Negative_regulation of GRIN3B 19 0.54 14.53 11.5 99.08
19 INT136339 Gene_expression of Mmp10 3 0.07 1.05 1.75 99.08
20 INT2543 Positive_regulation of Calca 787 0.70 331.13 592.08 99.04
21 INT114507 Negative_regulation of Gene_expression of NAV1 17 0.43 7.24 15.93 99.00
22 INT66394 Regulation of Pdc 6 0.32 1.27 3.99 98.80
23 INT110638 Negative_regulation of COMT 43 0.59 21.03 21.05 98.64
24 INT265659 Positive_regulation of Negative_regulation of COMT 1 0.43 0.78 1.57 98.64
25 INT22798 Regulation of Shbg 64 0.60 26.71 8.76 98.20
26 INT528 Gene_expression of Prl 693 0.78 217.18 192.2 97.92
27 INT98927 Localization of Grm1 4 0.71 0.42 1.97 97.80
28 INT121019 Positive_regulation of Remslp1 1 0.10 0.57 0.66 97.76
29 INT1912 Gene_expression of Calca 1152 0.78 453.25 739.84 97.72
30 INT6665 Gene_expression of FOS 520 0.77 165.31 217.66 97.56
31 INT27261 Regulation of Regulation of Calca 7 0.45 2.8 5.08 97.00
32 INT7341 Positive_regulation of Grin1 169 0.70 65.86 118.38 97.00
33 INT167057 Binding of Myo5a 1 0.46 0.37 1.88 96.76
34 INT160021 Negative_regulation of Slc12a4 2 0.06 0.42 0.47 96.68
35 INT57957 Localization of TXNRD1 14 0.64 4.01 2.7 96.56
36 INT76428 Gene_expression of Sstr2 24 0.76 6.09 12.32 96.52
37 INT5200 Gene_expression of Fos 3083 0.78 894.43 1639.02 96.32
38 INT6056 Negative_regulation of Gene_expression of Fos 601 0.59 193.05 386.84 96.32
39 INT5199 Gene_expression of Fosl1 44 0.78 8.66 24.8 95.96
40 INT5201 Negative_regulation of Gene_expression of Fosl1 8 0.54 1.63 5.06 95.96
41 INT5591 Regulation of Gene_expression of Fos 425 0.62 129.06 265.78 95.64
42 INT5587 Regulation of Fos 191 0.62 40.81 99.7 95.64
43 INT18190 Regulation of DRD2 11 0.60 9.01 7.63 95.64
44 INT94450 Gene_expression of Nav1 359 0.78 131.85 275.46 95.24
45 INT103262 Localization of Nav1 53 0.81 19.23 34.44 95.24
46 INT5040 Regulation of Gal 42 0.60 12.72 21.18 95.16
47 INT85766 Gene_expression of Scn11a 19 0.78 6.82 8.24 95.00
48 INT9381 Positive_regulation of TRPV1 523 0.70 187.4 276.05 94.72
49 INT48248 Gene_expression of Scn10a 38 0.78 19.3 25.05 94.68
50 INT7344 Gene_expression of TAC1 132 0.75 35.48 68.26 94.04
51 INT2649 Regulation of Calca 433 0.62 146.05 330.95 93.96
52 INT53460 Gene_expression of tn 13 0.66 7.97 5.2 93.92
53 INT9383 Localization of TRPV1 98 0.81 33.23 46.24 93.60
54 INT116819 Negative_regulation of Localization of TRPV1 3 0.43 1.75 2.71 93.60
55 INT129303 Positive_regulation of NAV1 54 0.70 36.92 57.45 93.52
56 INT11087 Positive_regulation of Drd2 54 0.69 12.4 31.43 93.12
57 INT136334 Negative_regulation of Mmp10 1 0.04 0.51 1.41 93.04
58 INT136338 Negative_regulation of Regulation of Mmp10 1 0.03 0.51 1.41 93.04
59 INT98621 Regulation of Trpv1 121 0.62 79.24 75.23 92.96
60 INT5307 Regulation of Tnf 87 0.62 78.71 43.4 92.72
61 INT317185 Positive_regulation of Positive_regulation of NAV1 1 0.47 1.51 2.08 92.48
62 INT4925 Binding of Tacr1 57 0.48 17.39 38.38 92.44
63 INT89048 Gene_expression of P2RX2 28 0.75 8.75 7.9 92.04
64 INT144736 Negative_regulation of Gene_expression of COMT 13 0.58 6.47 9.28 92.04
65 INT10568 Regulation of H2-Ab1 9 0.20 1.86 6.79 91.68
66 INT94658 Positive_regulation of F2rl1 51 0.70 33.65 27.46 91.60
67 INT103791 Positive_regulation of Positive_regulation of F2rl1 10 0.50 11.24 7.41 91.60
68 INT122953 Gene_expression of COMT 65 0.77 25.84 40.49 91.56
69 INT136335 Regulation of Mmp10 4 0.11 1.53 2.54 90.64
70 INT71916 Gene_expression of TTN 9 0.75 1.69 0.97 89.88
71 INT626 Localization of CALCA 289 0.81 125.39 221.15 88.72
72 INT8358 Negative_regulation of Localization of CALCA 25 0.59 11.79 21.51 88.72
73 INT100569 Positive_regulation of Binding of Tacr1 1 0.50 0.66 1.37 88.68
74 INT77339 Positive_regulation of RRM2 5 0.41 1.36 2.88 88.04
75 INT117205 Transcription of Esr1 23 0.65 9.4 4.14 85.84
76 INT19995 Gene_expression of Prph 16 0.75 8.11 5.52 84.48
77 INT1273 Gene_expression of Avp 356 0.78 90.56 138.7 82.80
78 INT48923 Gene_expression of Ephb1 211 0.77 106.23 109.9 81.84
79 INT21937 Positive_regulation of Scly 16 0.39 22.34 13.76 81.00
80 INT63932 Positive_regulation of Ephb1 537 0.70 259.67 296.14 80.88
81 INT53459 Negative_regulation of Gene_expression of tn 2 0.42 0.85 1.13 80.36
82 INT32074 Positive_regulation of TAR 4 0.40 1.44 0.98 79.92
83 INT58477 Gene_expression of Chdh 33 0.74 39.48 19.78 79.40
84 INT22909 Positive_regulation of Chdh 26 0.68 28.69 16.13 78.92
85 INT180035 Positive_regulation of Gene_expression of Chdh 2 0.22 8.21 5.78 78.92
86 INT12763 Phosphorylation of Prkcg 167 0.82 38.91 89.63 78.40
87 INT12765 Positive_regulation of Phosphorylation of Prkcg 59 0.66 20.16 34.67 78.40
88 INT58400 Negative_regulation of Tnf 182 0.59 129.97 71 78.08
89 INT163217 Transcription of Sstr2 5 0.67 0.62 5.42 78.00
90 INT50957 Negative_regulation of Il6 134 0.59 79.08 42.67 77.28
91 INT16356 Regulation of NPPA 33 0.62 13.24 9.53 76.92
92 INT317187 Positive_regulation of BMS1 1 0.04 0.98 1.48 76.08
93 INT149518 Regulation of Gene_expression of NAV1 7 0.62 6.73 9.62 75.32
94 INT5202 Positive_regulation of Gene_expression of Fos 1163 0.70 319.28 684 75.00
95 INT12501 Positive_regulation of Adarb1 166 0.58 36.94 118.92 75.00
96 INT57866 Positive_regulation of Gene_expression of Adarb1 2 0.04 0.25 1.44 75.00
97 INT6165 Gene_expression of Adarb1 85 0.58 18.39 51.03 75.00
98 INT84430 Negative_regulation of Smpd1 22 0.59 10.33 3.95 75.00
99 INT5228 Positive_regulation of Fos 934 0.70 209.8 503.87 75.00
100 INT5940 Negative_regulation of Avp 236 0.59 67.86 101.2 75.00
101 INT160022 Transcription of Slc12a2 2 0.53 0.75 0.97 75.00
102 INT160020 Transcription of Slc12a5 2 0.53 0.75 0.83 75.00
103 INT160019 Regulation of Transcription of Slc12a2 1 0.26 0.41 0.46 75.00
104 INT160670 Negative_regulation of Pdia3 3 0.42 0.7 0.22 75.00
105 INT127576 Transcription of Gal 6 0.67 4.36 3.04 74.64
106 INT51163 Gene_expression of Gal 119 0.78 67.48 49.23 74.64
107 INT14031 Gene_expression of Npy 107 0.78 36.48 35.4 74.64
108 INT21795 Transcription of Npy 7 0.57 2.94 2.27 74.64
109 INT90865 Regulation of Scly 5 0.23 3.26 1.34 73.84
110 INT113391 Regulation of Positive_regulation of Tacr1 2 0.35 0.5 0.27 73.84
111 INT50992 Regulation of Negative_regulation of Fos 2 0.26 0.73 2.22 73.68
112 INT84495 Positive_regulation of Positive_regulation of Ephb1 85 0.70 46.12 54.11 73.12
113 INT44773 Negative_regulation of LBR 6 0.57 2.32 2.03 72.80
114 INT51158 Positive_regulation of Tacr1 33 0.70 15.22 13.91 72.60
115 INT317186 Regulation of BMS1 1 0.04 3.9 3.17 72.32
116 INT27260 Gene_expression of DYNLL1 8 0.75 7.72 2.78 72.20
117 INT17459 Positive_regulation of Gene_expression of FOS 182 0.67 53.45 96.38 71.92
118 INT9382 Regulation of TRPV1 149 0.62 53.99 77.46 70.56
119 INT11766 Negative_regulation of H2-Ab1 15 0.43 5.27 12.32 70.16
120 INT62546 Positive_regulation of Gene_expression of Icam1 60 0.70 59.52 16.9 69.68
121 INT63169 Positive_regulation of Gene_expression of Selp 35 0.69 21.95 7.16 69.68
122 INT157575 Positive_regulation of Gene_expression of Ccl12 3 0.63 3.05 1.59 69.68
123 INT62543 Gene_expression of Icam1 231 0.78 187.58 52.71 69.28
124 INT49141 Gene_expression of Selp 157 0.78 85.22 24.78 69.28
125 INT117551 Regulation of Gene_expression of Selp 15 0.44 7.32 4.2 69.28
126 INT62545 Regulation of Gene_expression of Icam1 17 0.49 14.26 4.06 69.28
127 INT157572 Gene_expression of Ccl12 10 0.70 10.52 3.09 69.28
128 INT157571 Regulation of Gene_expression of Ccl12 1 0.41 0.58 0.47 69.28
129 INT10808 Negative_regulation of Negative_regulation of Fos 3 0.57 1.08 3.92 68.40
130 INT24525 Regulation of Gal 19 0.60 10.17 9.57 67.36
131 INT2541 Binding of Calca 200 0.48 67.14 134.62 64.68
132 INT12424 Binding of Npy 48 0.48 8.23 24.26 64.68
133 INT6108 Gene_expression of Npy 292 0.78 110.65 148.21 63.80
134 INT5283 Positive_regulation of Npy 191 0.70 66.77 109.2 63.80
135 INT56447 Positive_regulation of Icam1 64 0.64 64.14 16.16 63.40
136 INT63170 Positive_regulation of Selp 27 0.68 24.1 6.3 63.40
137 INT157576 Positive_regulation of Localization of Selp 2 0.49 1.19 0.59 63.40
138 INT157574 Positive_regulation of Localization of Icam1 1 0.46 0.56 0.51 63.40
139 INT156579 Localization of Selp 14 0.73 6.53 2.69 62.88
140 INT5590 Negative_regulation of Fos 144 0.59 40.94 81.98 62.64
141 INT60768 Negative_regulation of Pdc 5 0.48 1.5 2.67 62.48
142 INT144946 Localization of Icam1 21 0.75 21.84 5.33 62.28
143 INT97375 Positive_regulation of Gene_expression of Scn10a 5 0.67 2.92 3.98 62.00
144 INT307700 Regulation of HOPX 4 0.53 7.64 3.5 61.68
145 INT116226 Regulation of NAV1 20 0.51 14.32 25.61 61.16
146 INT5842 Gene_expression of Gfap 372 0.78 153.71 127.71 60.88
147 INT5843 Positive_regulation of Gfap 184 0.70 108.2 70.21 60.04
148 INT105157 Positive_regulation of Phosphorylation of Gfap 8 0.67 6.48 6.38 60.04
149 INT4824 Positive_regulation of Tacr1 169 0.70 66.1 123.46 59.20
150 INT105156 Phosphorylation of Gfap 23 0.79 11.85 13.76 57.44
151 INT157573 Localization of Vwf 9 0.69 2.93 0.97 57.04
152 INT66023 Positive_regulation of Gene_expression of Itgam 25 0.64 12.65 16.56 56.76
153 INT90911 Positive_regulation of Phosphorylation of Grin1 62 0.70 27.45 59.26 56.76
154 INT108098 Positive_regulation of Itgam 19 0.70 8.09 8.86 56.76
155 INT131631 Transcription of S100a10 1 0.66 0.89 0.64 56.16
156 INT90910 Phosphorylation of Grin1 150 0.82 68.23 139.24 55.56
157 INT324955 Phosphorylation of Itgam 1 0.37 1.96 2.4 55.40
158 INT136337 Positive_regulation of Mmp10 1 0.12 0.91 1.2 54.08
159 INT60769 Positive_regulation of Pdc 3 0.33 0.2 1.7 54.00
160 INT10706 Regulation of Il6 150 0.62 93.23 62.34 53.28
161 INT66025 Gene_expression of Itgam 61 0.78 31.26 26.08 53.28
162 INT2630 Positive_regulation of Shbg 134 0.70 65.26 15.19 51.20
163 INT11854 Gene_expression of Il1rl1 57 0.77 30.19 38.25 50.00
164 INT10915 Gene_expression of ITGAM 164 0.78 92.42 29.78 50.00
165 INT10917 Positive_regulation of ITGAM 31 0.67 16.39 6.69 50.00
166 INT38698 Positive_regulation of COP 9 0.59 2.05 4.48 50.00
167 INT112 Gene_expression of Pdia3 11 0.74 0.18 3.74 50.00
168 INT62850 Negative_regulation of COP 8 0.37 0.18 0.38 50.00
169 INT138438 Gene_expression of Smpd1 7 0.67 2.67 0.21 50.00
170 INT130369 Binding of COP 1 0.30 0.05 0 50.00
171 INT169375 Phosphorylation of ITGAM 1 0.61 0.16 0 50.00
172 INT21956 Negative_regulation of Mmp7 12 0.34 7.32 5.34 49.48
173 INT44772 Negative_regulation of Negative_regulation of LBR 2 0.42 0.38 0.92 47.68
174 INT12369 Negative_regulation of Htr3a 28 0.59 8.78 12.62 47.24
175 INT200738 Gene_expression of HIST2H4A 7 0.18 4.65 0.91 45.64
176 INT4941 Positive_regulation of Oprd1 345 0.70 74.26 304.41 44.56
177 INT131632 Negative_regulation of Positive_regulation of Scn10a 1 0.41 0.89 0.53 44.40
178 INT91932 Positive_regulation of Scn10a 18 0.67 10.39 10.9 42.32
179 INT132671 Positive_regulation of RT1-M3-1 1 0.01 0.37 0.46 42.24
180 INT132672 Positive_regulation of Psat1 1 0.17 0.37 0.46 41.60
181 INT125897 Binding of Mmp9 3 0.36 2.36 1.32 40.72
182 INT97891 Gene_expression of Ghrl 108 0.77 24.85 9.7 40.64
183 INT132674 Positive_regulation of LOC687750 1 0.06 0.37 0.45 38.32
184 INT49134 Gene_expression of Grin1 270 0.78 84.78 148.61 36.08
185 INT52692 Gene_expression of Ptgs2 160 0.78 85.06 55.73 34.56
186 INT55014 Positive_regulation of Ednrb 31 0.70 16.61 9.68 34.16
187 INT3362 Negative_regulation of Emg1 21 0.57 10.03 15.93 33.44
188 INT11303 Gene_expression of Avp 116 0.78 39.23 23.88 33.12
189 INT57222 Gene_expression of ATF3 22 0.78 54.71 3.28 32.56
190 INT132673 Positive_regulation of Syn2 1 0.14 0.31 0.44 31.92
191 INT29971 Gene_expression of Oprk1 126 0.78 35.32 93.97 29.08
192 INT886 Gene_expression of Pomc 676 0.78 129.87 295.98 25.00
193 INT16654 Gene_expression of Insrr 138 0.46 58.96 75.68 25.00
194 INT6894 Gene_expression of CNR1 168 0.78 74.07 62.84 25.00
195 INT6669 Negative_regulation of Positive_regulation of Fos 98 0.59 23.5 56.82 25.00
196 INT14009 Gene_expression of Sst 66 0.77 19.6 37.3 25.00
197 INT6067 Positive_regulation of Positive_regulation of Oprd1 37 0.69 6.56 36.58 25.00
198 INT7903 Positive_regulation of Fosl1 21 0.70 3.53 11.36 25.00
199 INT132411 Positive_regulation of Ghrl 25 0.69 12.05 2.59 25.00
200 INT123843 Gene_expression of soc 14 0.58 5.22 1.96 25.00
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