P:Facet joint

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Pain Term
Category Anatomy
Synonyms Facet Joints
Pain Specific No
Documents 873
Hot Single Events 64
Hot Interactions 3

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported for Facet joint. They are ordered first by their pain relevance and then by number of times they were reported for Facet joint. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT84921 Binding of NGF and NTRK1 13 0.50 6.39 6.1 98.32
2 INT159658 Positive_regulation of Binding of NGF and NTRK1 1 0.35 0.09 0.18 97.44
3 INT318981 Binding of CALR and GOPC 1 0.03 0.77 0.64 93.88
4 INT159657 Binding of INSRR and NGF 3 0.00 1.65 1.48 75.00
5 INT159655 Binding of BDNF and INSRR 2 0.00 1.25 1.26 75.00
6 INT159656 Binding of BDNF and NTRK1 1 0.26 0.34 0.26 75.00
7 INT265566 Binding of PDE4D and PTPN5 1 0.03 0.81 0.85 5.00
8 INT318980 Binding of CALR and Positive_regulation of Localization of GOPC 1 0.04 0.32 0.24 5.00
9 INT196592 Binding of CFD and GHRH 1 0.02 1.88 0.07 5.00
10 INT287234 PDLIM7 Positive_regulation of Gene_expression of BMP7 1 0.14 0.12 0.03 5.00
11 INT287233 PDLIM7 Positive_regulation of Gene_expression of BMP2 1 0.07 0.12 0.03 5.00
12 INT197761 Binding of KRT5 and C4a 1 0.02 2.29 0 5.00
13 INT197762 Binding of KRT5 and Cpe 1 0.19 1.14 0 5.00
14 INT197760 Binding of C4a and Cpe 1 0.01 1.14 0 5.00
15 INT345060 Binding of SGCG and C2 1 0.00 0.93 0 5.00
16 INT345059 Binding of C3 and C2 1 0.00 0 0 5.00
17 INT274705 Binding of TXNRD1 and Dh 1 0.00 0 0 5.00

Single Events

The table below shows the top 200 pain related interactions that have been reported for Facet joint. They are ordered first by their pain relevance and then by number of times they were reported in Facet joint. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT141151 Regulation of PSMD1 16 0.40 8.19 5.86 100.00
2 INT166581 Positive_regulation of SYTL1 1 0.06 1.11 0.25 99.90
3 INT1912 Gene_expression of Calca 1152 0.78 453.25 739.84 99.76
4 INT4893 Gene_expression of Tacr1 366 0.78 129.67 213.92 99.76
5 INT16167 Negative_regulation of DMD 186 0.57 108.71 15.25 99.56
6 INT1027 Gene_expression of Lbp 132 0.77 106.7 54.16 99.20
7 INT48312 Gene_expression of NTRK1 72 0.78 38.21 22.24 99.04
8 INT245741 Negative_regulation of Gene_expression of DISC1 2 0.17 1.29 0.34 98.92
9 INT322367 Positive_regulation of NPS 2 0.45 0 3.8 98.78
10 INT571 Negative_regulation of C2 9 0.43 3.93 1.54 98.62
11 INT58061 Gene_expression of Trpv1 1117 0.78 451.54 637.59 98.52
12 INT245736 Gene_expression of DISC1 13 0.61 7.65 1.33 98.52
13 INT13353 Positive_regulation of Tnf 332 0.70 248.75 148.1 98.40
14 INT66941 Localization of NTRK1 8 0.78 5.89 1.96 98.32
15 INT5307 Regulation of Tnf 87 0.62 78.71 43.4 98.20
16 INT140151 Gene_expression of Tens1 9 0.67 5.84 13.68 98.18
17 INT62374 Gene_expression of NGF 158 0.78 77.87 76.45 98.16
18 INT9158 Gene_expression of Tnf 722 0.78 522.01 277.68 98.12
19 INT20216 Localization of NGF 40 0.80 18.16 16.61 97.96
20 INT45266 Negative_regulation of Nenf 3 0.38 2.46 3.59 97.88
21 INT1273 Gene_expression of Avp 356 0.78 90.56 138.7 97.24
22 INT2976 Regulation of Bche 29 0.45 8.56 9.42 97.12
23 INT2611 Negative_regulation of AQP1 17 0.39 10.04 2.15 97.12
24 INT211054 Positive_regulation of AQP1 3 0.33 4.53 1.41 97.12
25 INT211055 Binding of PAX5 2 0.33 0.85 0.18 97.12
26 INT211048 Negative_regulation of Binding of PAX5 1 0.29 0.1 0.05 97.12
27 INT211050 Positive_regulation of Binding of PAX5 1 0.34 0.1 0.05 97.12
28 INT41590 Positive_regulation of PAX5 10 0.42 3.1 0.91 96.56
29 INT192687 Negative_regulation of PAX5 9 0.40 1.42 0.08 96.56
30 INT105021 Binding of GOPC 187 0.40 60.39 20.38 96.48
31 INT74166 Positive_regulation of C2 10 0.55 2.83 1.05 96.48
32 INT615 Regulation of Alb 66 0.62 33.43 15.33 95.48
33 INT90091 Gene_expression of GOPC 967 0.67 366.22 103.6 94.72
34 INT9664 Binding of LBP 127 0.48 94.9 63.42 94.16
35 INT165228 Binding of BMI1 13 0.47 25.36 7.97 94.16
36 INT69592 Positive_regulation of PSMD1 27 0.70 17.83 18.98 93.60
37 INT1876 Positive_regulation of HLA-B 82 0.69 52.16 21.08 93.12
38 INT202606 Regulation of PTPN5 1 0.26 3.92 3.04 91.04
39 INT11141 Negative_regulation of Gene_expression of Avp 23 0.59 3.85 12.19 90.96
40 INT19763 Gene_expression of CTs 69 0.78 32.92 18.87 89.84
41 INT9408 Positive_regulation of Crp 296 0.69 242.27 57.35 89.48
42 INT11101 Regulation of Gene_expression of Lbp 6 0.61 5.43 3.49 89.12
43 INT166582 Negative_regulation of Localization of SYTL1 1 0.05 1.09 0.27 88.56
44 INT48577 Gene_expression of Capn3 3 0.67 0.61 0.97 87.84
45 INT114664 Binding of BMP2 12 0.37 6.54 0.91 87.60
46 INT2541 Binding of Calca 200 0.48 67.14 134.62 86.48
47 INT67275 Gene_expression of L2 6 0.66 1.9 2.63 86.08
48 INT124884 Gene_expression of Rpl4 3 0.53 1.56 0.9 85.52
49 INT204019 Negative_regulation of C2 10 0.26 6.23 2.44 85.44
50 INT74235 Localization of Bche 2 0.54 0.1 0.52 84.96
51 INT107637 Regulation of Localization of Bche 1 0.27 0.1 0.37 84.96
52 INT166583 Negative_regulation of SYTL1 1 0.05 1.09 0.26 84.88
53 INT166580 Localization of SYTL1 1 0.09 1.09 0.26 84.88
54 INT124885 Gene_expression of Insrr 1 0.05 0.65 0.77 84.24
55 INT46173 Transcription of C3 4 0.61 3.54 0.53 83.68
56 INT49791 Transcription of C2 1 0.18 0.27 0.18 83.12
57 INT110076 Regulation of C6 2 0.22 1.14 0.96 82.64
58 INT1030 Localization of Lbp 52 0.74 38.92 24.91 82.36
59 INT222153 Binding of MAP6 1 0.03 1.83 0.53 81.60
60 INT71152 Negative_regulation of NTRK1 15 0.59 10.28 5.5 81.52
61 INT158987 Positive_regulation of Gene_expression of Acrv1 1 0.24 1.02 1.83 81.32
62 INT62373 Negative_regulation of NGF 34 0.59 25.87 22.38 81.12
63 INT30531 Gene_expression of C2 15 0.66 5.5 1.99 80.72
64 INT52732 Negative_regulation of CRP 169 0.59 138.47 40.33 80.32
65 INT143122 Gene_expression of Acrv1 3 0.37 2.75 2.72 79.72
66 INT137052 Positive_regulation of PYCARD 30 0.43 4.72 6.17 78.56
67 INT73234 Positive_regulation of Lbp 13 0.69 12.55 8.57 78.00
68 INT196593 Phosphorylation of CFD 1 0.55 0.84 0.04 76.64
69 INT202602 Positive_regulation of PTPN5 4 0.29 3.34 1.83 75.12
70 INT75929 Gene_expression of IL9 61 0.43 24.71 16.17 75.00
71 INT85418 Positive_regulation of Gene_expression of IL9 11 0.38 11.47 9.56 75.00
72 INT85413 Negative_regulation of IL9 5 0.47 4.42 4.77 75.00
73 INT85415 Positive_regulation of IL9 10 0.28 6.93 4.71 75.00
74 INT156542 Positive_regulation of Negative_regulation of IL9 1 0.05 3.29 3.13 75.00
75 INT75999 Gene_expression of BDNF 344 0.78 114.19 83.12 75.00
76 INT48313 Binding of NTRK1 19 0.47 14.44 6.12 75.00
77 INT23435 Positive_regulation of NGF 54 0.70 32.41 30.11 75.00
78 INT47011 Positive_regulation of Gusb 14 0.44 8.93 2.87 73.96
79 INT16166 Positive_regulation of DMD 348 0.67 133.22 15.06 73.36
80 INT110075 Binding of FTH1 10 0.36 1.12 1.13 71.04
81 INT573 Negative_regulation of C3 60 0.59 41.37 7.78 69.72
82 INT9082 Positive_regulation of ESR1 238 0.69 148.51 36.69 65.04
83 INT20462 Binding of ESR1 210 0.44 102.7 26.34 65.04
84 INT161549 Negative_regulation of TDRD6 2 0.17 1.08 0.58 63.52
85 INT5940 Negative_regulation of Avp 236 0.59 67.86 101.2 62.56
86 INT17110 Gene_expression of PSMD1 60 0.65 19.57 4.69 61.48
87 INT148721 Binding of PSMD1 13 0.31 4.78 1.76 60.40
88 INT5841 Gene_expression of Vim 181 0.72 138.54 16.33 60.24
89 INT52937 Gene_expression of Cd68 37 0.67 31.33 7.54 60.24
90 INT170855 Negative_regulation of GOPC 188 0.38 70.92 15.41 59.76
91 INT69593 Negative_regulation of PSMD1 11 0.57 4.06 3.33 59.76
92 INT58477 Gene_expression of Chdh 33 0.74 39.48 19.78 59.72
93 INT22909 Positive_regulation of Chdh 26 0.68 28.69 16.13 59.24
94 INT180035 Positive_regulation of Gene_expression of Chdh 2 0.22 8.21 5.78 59.24
95 INT9088 Negative_regulation of LBP 48 0.58 33.06 25.89 56.48
96 INT350378 Localization of Lrba 1 0.64 1.09 0.29 55.84
97 INT350379 Positive_regulation of Lrba 1 0.40 1.09 0.29 55.84
98 INT1878 Binding of HLA-B 440 0.48 321.16 127.36 54.64
99 INT251459 Binding of Ie 18 0.20 6.62 0.75 54.52
100 INT144302 Protein_catabolism of MMP3 7 0.86 7.43 3.98 54.48
101 INT174029 Protein_catabolism of BSG 5 0.01 2.5 0.95 54.24
102 INT140350 Binding of C2 17 0.36 3.97 4.69 52.80
103 INT347937 Regulation of Binding of C2 1 0.03 0.31 0.12 52.80
104 INT39414 Gene_expression of SNRPB 37 0.59 14.07 2.52 52.44
105 INT142234 Gene_expression of CLINT1 2 0.58 0.75 0.03 52.12
106 INT1026 Binding of Lbp 207 0.48 150.96 119.16 50.00
107 INT11380 Negative_regulation of IL1B 215 0.59 125.62 72.35 50.00
108 INT58400 Negative_regulation of Tnf 182 0.59 129.97 71 50.00
109 INT6849 Localization of IL1B 229 0.81 112.56 69.63 50.00
110 INT48901 Negative_regulation of IL6 186 0.57 136.33 57.87 50.00
111 INT66029 Negative_regulation of Tnf 100 0.59 84.28 48.16 50.00
112 INT50957 Negative_regulation of Il6 134 0.59 79.08 42.67 50.00
113 INT1120 Gene_expression of C3 33 0.67 22.86 7.56 50.00
114 INT60440 Localization of PSMD1 10 0.74 3.94 2.57 50.00
115 INT45448 Gene_expression of Vom1r68 9 0.03 1.94 1.5 50.00
116 INT93054 Regulation of Vom1r68 4 0.20 0.17 1.26 50.00
117 INT93055 Regulation of C3 4 0.40 1.81 1.12 50.00
118 INT93056 Regulation of C2 3 0.44 1.42 0.34 50.00
119 INT139812 Gene_expression of Sh3gl3 1 0.09 0.05 0 50.00
120 INT293564 Binding of ESCO1 1 0.33 1 0.44 48.92
121 INT147583 Gene_expression of AIS 82 0.58 48.7 7.11 48.56
122 INT44678 Phosphorylation of CTS 5 0.70 2.63 1.7 48.36
123 INT1759 Gene_expression of TIMP1 267 0.77 133.87 59.29 44.68
124 INT1758 Positive_regulation of Gene_expression of TIMP1 62 0.69 31.72 13.98 44.68
125 INT93664 Gene_expression of TIMP2 33 0.67 36.67 7.14 44.24
126 INT187026 Positive_regulation of Gene_expression of TIMP2 3 0.47 2.05 0.96 44.24
127 INT256742 Positive_regulation of Cdr1 10 0.27 2.89 0.81 42.80
128 INT29094 Binding of C3 39 0.37 12.65 2.27 40.48
129 INT265567 Localization of PTPN5 1 0.49 1.39 1.47 39.20
130 INT164975 Binding of ELN 6 0.35 6.38 0.64 38.60
131 INT248660 Localization of CERS2 1 0.47 0.26 0 36.96
132 INT178898 Gene_expression of PTPN5 4 0.38 3.06 1.4 33.16
133 INT5235 Negative_regulation of TNF 924 0.59 772.91 331.98 32.96
134 INT6481 Binding of TNF 624 0.48 510.2 214.82 30.64
135 INT8358 Negative_regulation of Localization of CALCA 25 0.59 11.79 21.51 28.40
136 INT116819 Negative_regulation of Localization of TRPV1 3 0.43 1.75 2.71 28.40
137 INT77435 Positive_regulation of Nos2 343 0.70 208.49 91.43 28.00
138 INT626 Localization of CALCA 289 0.81 125.39 221.15 27.92
139 INT9383 Localization of TRPV1 98 0.81 33.23 46.24 27.92
140 INT32624 Regulation of LBP 15 0.60 11.48 8.71 25.24
141 INT160599 Regulation of Gene_expression of LBP 2 0.44 1.23 0.92 25.24
142 INT69992 Negative_regulation of Hmox2 93 0.50 49.01 44.07 25.00
143 INT19759 Gene_expression of LBP 77 0.77 56.44 33.23 25.00
144 INT100616 Negative_regulation of Rpl3 1 0.24 0.22 0.07 25.00
145 INT306420 Transcription of FTH1 1 0.12 0.18 0.03 24.24
146 INT4067 Negative_regulation of Esr1 97 0.50 43.45 17.52 19.00
147 INT148686 Localization of C6 5 0.31 4.27 0.64 17.76
148 INT20425 Localization of Cpe 23 0.81 5.18 9.14 16.52
149 INT344943 Regulation of TDRD6 1 0.18 0.16 0.08 15.36
150 INT307077 Gene_expression of Activ3 1 0.07 0 0 15.04
151 INT216454 Binding of Lif 2 0.27 0.85 0.07 13.52
152 INT16165 Regulation of DMD 114 0.60 35.13 3.64 7.92
153 INT53434 Positive_regulation of T 7 0.07 3.67 2.09 7.88
154 INT822 Gene_expression of ESR1 529 0.78 302.16 63.64 7.12
155 INT17612 Gene_expression of CRP 676 0.78 580.61 119.03 6.72
156 INT82265 Gene_expression of Lif 7 0.50 6.17 3.4 5.84
157 INT333439 Positive_regulation of Gene_expression of Lif 1 0.18 0.18 0.04 5.84
158 INT68684 Gene_expression of VEGFA 2371 0.78 1742.52 259.2 5.08
159 INT29496 Gene_expression of MMP3 136 0.75 49.49 41.78 5.08
160 INT6483 Gene_expression of TNF 3152 0.78 2515.62 929.82 5.00
161 INT76660 Gene_expression of Trpv1 691 0.78 329.46 386.42 5.00
162 INT94450 Gene_expression of Nav1 359 0.78 131.85 275.46 5.00
163 INT6665 Gene_expression of FOS 520 0.77 165.31 217.66 5.00
164 INT2451 Positive_regulation of Avp 355 0.70 102.66 147.69 5.00
165 INT9660 Regulation of TNF 363 0.62 312.94 139.99 5.00
166 INT5008 Localization of Calca 204 0.81 80.35 125.16 5.00
167 INT65731 Gene_expression of Cnr1 234 0.78 63.82 109.34 5.00
168 INT15769 Gene_expression of Il1b 146 0.78 114.51 75.35 5.00
169 INT98621 Regulation of Trpv1 121 0.62 79.24 75.23 5.00
170 INT9236 Regulation of Gene_expression of TNF 204 0.62 162.66 72.99 5.00
171 INT7134 Localization of KNG1 127 0.79 65.73 67.97 5.00
172 INT65733 Positive_regulation of Cnr1 125 0.70 40.27 67.33 5.00
173 INT15514 Negative_regulation of Crp 275 0.59 194.6 64.86 5.00
174 INT65730 Gene_expression of Cnr2 129 0.78 60.15 63.1 5.00
175 INT14740 Gene_expression of TGFB1 272 0.78 168.48 60.18 5.00
176 INT647 Gene_expression of SGCG 211 0.75 78.46 55.82 5.00
177 INT1456 Regulation of Oprl1 61 0.62 19.5 52.87 5.00
178 INT50334 Negative_regulation of Cnr1 84 0.58 30.86 51.75 5.00
179 INT1028 Positive_regulation of Lbp 102 0.69 67.86 46.05 5.00
180 INT80124 Negative_regulation of VEGFA 450 0.58 311.19 44.53 5.00
181 INT98498 Binding of Trpv1 75 0.48 33.67 44.4 5.00
182 INT613 Gene_expression of Alb 268 0.78 149.84 42.78 5.00
183 INT9372 Negative_regulation of Lbp 86 0.58 46.54 41.71 5.00
184 INT5793 Binding of CTS 110 0.48 63.91 40.62 5.00
185 INT116321 Regulation of Nav1 38 0.62 26.62 37.97 5.00
186 INT12892 Negative_regulation of TIMP1 136 0.58 83.13 36.54 5.00
187 INT101992 Localization of VEGFA 413 0.81 258.23 36.15 5.00
188 INT111052 Positive_regulation of Gene_expression of Nav1 44 0.70 18.98 35.28 5.00
189 INT66005 Regulation of Cnr1 47 0.61 19.21 34.52 5.00
190 INT103262 Localization of Nav1 53 0.81 19.23 34.44 5.00
191 INT34465 Regulation of Oprd1 34 0.45 7.14 34.29 5.00
192 INT53475 Gene_expression of MRI1 116 0.59 77.68 33.98 5.00
193 INT48693 Regulation of VEGFA 268 0.62 191.88 31.52 5.00
194 INT99688 Negative_regulation of Gene_expression of VEGFA 274 0.58 201.8 31.1 5.00
195 INT719 Negative_regulation of SGCG 96 0.57 47.91 30.22 5.00
196 INT15610 Localization of GOPC 223 0.65 68.26 28.7 5.00
197 INT78251 Positive_regulation of LBP 38 0.69 39.98 26.73 5.00
198 INT36428 Binding of Chdh 42 0.47 48.04 26.54 5.00
199 INT8836 Positive_regulation of SFTPA1 36 0.47 28.37 23.59 5.00
200 INT9292 Positive_regulation of SGCG 93 0.67 35.13 23.48 5.00
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