P:GCH1

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pChart

Pain Term
Category Molecule
Synonyms GCH1 GTP Cyclohydrolase 1
Pain Specific No
Documents 26
Hot Single Events 59
Hot Interactions 2

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported for GCH1. They are ordered first by their pain relevance and then by number of times they were reported for GCH1. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT324068 Binding of GCH1 and SNRNP70 1 0.01 28.19 40.6 100.00
2 INT324067 Regulation of Binding of GCH1 and SNRNP70 1 0.01 0.95 1.67 100.00
3 INT236491 GCH1 Regulation of Pain1 1 0.01 0.89 1.65 55.36
4 INT236489 Gtf3a Regulation of Pain1 1 0.00 0.52 0.56 5.00
5 INT236492 Gtf3a Regulation of SNRNP70 1 0.00 0.52 0.56 5.00

Single Events

The table below shows the top 200 pain related interactions that have been reported for GCH1. They are ordered first by their pain relevance and then by number of times they were reported in GCH1. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT162102 Gene_expression of Gch1 3 0.72 23.65 27.96 100.00
2 INT288515 Negative_regulation of Gene_expression of Gch1 1 0.47 9.26 10.41 100.00
3 INT150934 Gene_expression of GCH1 17 0.78 14.54 17.53 100.00
4 INT288526 Negative_regulation of Gch1 1 0.54 8.59 9.6 100.00
5 INT152347 Binding of GCH1 8 0.37 6.13 7.36 100.00
6 INT288524 Positive_regulation of Gene_expression of Gch1 1 0.56 5.03 6.02 100.00
7 INT139443 Positive_regulation of GCH1 9 0.69 8.2 10.14 100.00
8 INT163776 Regulation of GCH1 7 0.27 4.58 6.16 100.00
9 INT288517 Regulation of Gch1 1 0.50 2.96 3.19 100.00
10 INT288514 Positive_regulation of Gch1 1 0.43 1.91 2.35 100.00
11 INT150931 Negative_regulation of GCH1 6 0.59 1.23 1.05 100.00
12 INT150933 Negative_regulation of Positive_regulation of GCH1 3 0.58 1.8 2.77 100.00
13 INT150932 Positive_regulation of Gene_expression of GCH1 3 0.70 2.07 2.57 100.00
14 INT288516 Negative_regulation of Negative_regulation of Gch1 1 0.40 2.35 2.59 100.00
15 INT283973 Transcription of GCH1 1 0.61 1.99 2.33 100.00
16 INT258637 Regulation of Gene_expression of GCH1 1 0.62 1.77 2.02 100.00
17 INT283975 Negative_regulation of Localization of GCH1 1 0.38 1.99 2.27 100.00
18 INT288520 Negative_regulation of Positive_regulation of Gch1 1 0.40 0.67 1.02 100.00
19 INT288521 Protein_catabolism of Gch1 1 0.61 1.17 1.3 100.00
20 INT165434 Regulation of SPR 4 0.24 2.14 2.33 100.00
21 INT4740 Gene_expression of Th 298 0.78 61.27 154.03 100.00
22 INT288522 Positive_regulation of Transcription of Gch1 1 0.64 1.06 1.42 100.00
23 INT288525 Transcription of Gch1 1 0.66 1.06 1.41 100.00
24 INT288518 Regulation of Gene_expression of Gch1 1 0.42 0.91 0.88 100.00
25 INT95167 Positive_regulation of DRGX 33 0.22 26.72 21.04 100.00
26 INT283974 Negative_regulation of Transcription of GCH1 1 0.38 0.99 1.13 100.00
27 INT283972 Localization of GCH1 1 0.67 0.99 1.13 100.00
28 INT288513 Regulation of Negative_regulation of Gch1 1 0.42 1.03 1.07 100.00
29 INT165430 Gene_expression of SPR 2 0.59 1.27 0.75 100.00
30 INT283976 Positive_regulation of Binding of GCH1 1 0.45 1.27 1.13 100.00
31 INT4781 Gene_expression of TH 68 0.73 26.92 24.01 100.00
32 INT87941 Negative_regulation of DRGX 11 0.13 7.14 6.74 99.88
33 INT65481 Positive_regulation of Gene_expression of Pts 5 0.48 0.57 2.85 99.62
34 INT164779 Negative_regulation of Gene_expression of Pts 2 0.01 0.71 1.01 99.46
35 INT65480 Gene_expression of Pts 15 0.66 7.53 6.46 99.42
36 INT139442 Negative_regulation of Gene_expression of Blmh 2 0.03 2.19 2.53 99.28
37 INT48118 Gene_expression of KIAA0101 5 0.65 2.2 2.24 99.28
38 INT22939 Gene_expression of Csf2 164 0.78 85.1 32.22 99.26
39 INT236488 Regulation of Regulation of Pain1 1 0.01 0.76 1.23 99.12
40 INT139440 Gene_expression of Blmh 3 0.04 2.86 3.37 98.94
41 INT169180 Binding of SNRNP70 204 0.47 119.1 29.3 98.84
42 INT236485 Negative_regulation of Regulation of Pain1 1 0.01 0.76 1.23 98.84
43 INT150929 Negative_regulation of Gene_expression of Bh4p 1 0.00 0.44 0.69 98.80
44 INT150928 Gene_expression of Bh4p 3 0.02 1.97 2.18 98.80
45 INT139441 Positive_regulation of Blmh 1 0.03 0.98 1.19 98.68
46 INT178828 Regulation of Pain1 12 0.14 16.1 15.64 98.64
47 INT165433 Gene_expression of BLMH 1 0.20 1.06 1.52 98.28
48 INT288523 Regulation of Binding of Gch1 1 0.36 0.91 1.27 96.84
49 INT288519 Binding of Gch1 1 0.30 0.9 1.26 96.20
50 INT150927 Regulation of Bh4p 1 0.00 0.44 0.7 95.92
51 INT117601 Positive_regulation of Trpa1 174 0.70 72.41 71.9 94.32
52 INT165432 Negative_regulation of BLMH 3 0.13 1.62 1.37 94.12
53 INT165435 Negative_regulation of Positive_regulation of BLMH 1 0.13 0.52 0.79 94.12
54 INT165431 Positive_regulation of BLMH 1 0.15 0.52 0.79 93.60
55 INT11479 Positive_regulation of KCNMA1 30 0.68 10.07 10.82 93.44
56 INT150825 Binding of Comt 13 0.42 6.65 6.42 88.12
57 INT24569 Negative_regulation of Pain1 26 0.41 21.82 21.08 87.92
58 INT45175 Gene_expression of PTS 5 0.56 1.46 1.24 82.48
59 INT2383 Positive_regulation of CP 33 0.67 25.41 15.38 80.76
60 INT258772 Regulation of DDC 1 0.36 0.05 0.4 74.36
61 INT14360 Positive_regulation of DDC 7 0.70 2.97 2.02 73.20
62 INT144735 Gene_expression of DDC 8 0.75 3.21 5.31 72.08
63 INT177992 Positive_regulation of SNRNP70 28 0.49 16.14 4.28 70.44
64 INT122896 Negative_regulation of TH 23 0.57 9.27 6.88 70.04
65 INT170025 Gene_expression of Fig4 588 0.67 183.27 113.32 67.60
66 INT33134 Negative_regulation of Aadac 5 0.37 0.46 2.43 63.08
67 INT97701 Phosphorylation of Mapk14 191 0.82 115.33 100.46 62.88
68 INT97702 Positive_regulation of Phosphorylation of Mapk14 69 0.69 49.21 36.81 62.88
69 INT125384 Positive_regulation of Pain1 23 0.49 17.1 14.83 58.56
70 INT105670 Gene_expression of AAVS1 131 0.75 49.24 12.95 51.36
71 INT42980 Gene_expression of GAD1 139 0.69 94.77 45.11 51.36
72 INT105669 Positive_regulation of Gene_expression of AAVS1 20 0.49 9.02 2.06 51.36
73 INT2893 Localization of Oxt 219 0.80 28.96 79.43 50.00
74 INT17974 Positive_regulation of Localization of Oxt 34 0.69 4.45 12.9 50.00
75 INT18981 Gene_expression of ABAT 78 0.68 38.35 61.36 48.32
76 INT10797 Binding of CYP2D6 86 0.48 15.09 31.16 31.20
77 INT102731 Regulation of ABCB1 29 0.62 5.36 11.67 17.96
78 INT119053 Positive_regulation of SLC6A3 15 0.65 2.51 4 15.76
79 INT14843 Gene_expression of Gabrg1 301 0.77 62.63 139.16 5.00
80 INT21737 Binding of MC1R 129 0.48 45.45 56.54 5.00
81 INT6034 Binding of Gabrg1 115 0.47 17.48 51.92 5.00
82 INT9556 Negative_regulation of NAV1 47 0.59 28.49 49.33 5.00
83 INT1564 Localization of OPRM1 41 0.80 8.03 44.67 5.00
84 INT59466 Gene_expression of ISYNA1 204 0.77 112.57 35.48 5.00
85 INT9647 Gene_expression of PROC 163 0.65 89.76 26.75 5.00
86 INT76095 Positive_regulation of ISYNA1 117 0.55 79.73 25.86 5.00
87 INT116226 Regulation of NAV1 20 0.51 14.32 25.61 5.00
88 INT4535 Localization of PROC 106 0.73 76.24 21.1 5.00
89 INT52591 Gene_expression of KCNMA1 78 0.76 13.95 15.55 5.00
90 INT28314 Negative_regulation of Gene_expression of Gabrg1 29 0.44 12.56 13.8 5.00
91 INT113490 Gene_expression of SCN9A 22 0.77 5.45 12.27 5.00
92 INT21952 Gene_expression of GDNF 42 0.78 20.32 9.62 5.00
93 INT59465 Negative_regulation of ISYNA1 41 0.49 21.9 9.46 5.00
94 INT193663 Binding of Pain1 9 0.36 8.84 8.04 5.00
95 INT97693 Gene_expression of REST 29 0.75 5.51 5.26 5.00
96 INT14126 Gene_expression of Grina 13 0.67 4.63 4.57 5.00
97 INT6967 Regulation of KCNMA1 28 0.61 3.37 4.3 5.00
98 INT46208 Negative_regulation of Scn10a 6 0.58 7.16 3.46 5.00
99 INT46691 Negative_regulation of SCN9A 5 0.50 1.37 3.44 5.00
100 INT69313 Regulation of Scn10a 5 0.60 4.45 3.14 5.00
101 INT236490 Positive_regulation of SCN11A 2 0.48 0.91 2.37 5.00
102 INT76097 Negative_regulation of Positive_regulation of ISYNA1 5 0.31 2.47 1.95 5.00
103 INT236487 Positive_regulation of Gene_expression of Grina 2 0.08 1.77 1.45 5.00
104 INT108130 Localization of GDNF 3 0.74 1.36 1.38 5.00
105 INT179309 Regulation of Gene_expression of KCNMA1 8 0.39 2.36 1.36 5.00
106 INT208792 Negative_regulation of Gene_expression of TH 6 0.35 1.11 0.94 5.00
107 INT85138 Binding of GDNF 6 0.37 2.01 0.58 5.00
108 INT258771 Gene_expression of NRTN 1 0.25 0.78 0.11 5.00
109 INT150930 Positive_regulation of Bh4p 1 0.00 0.06 0 5.00
110 INT150926 Negative_regulation of Bh4p 1 0.00 0.06 0 5.00
111 INT163775 Negative_regulation of Regulation of GCH1 1 0.43 0 0 5.00
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