P:Hsan

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pChart

Pain Term
Category Disorder
Synonyms Congenital Insensitivity To Pain With Anhidrosis, Hereditary Sensory Autonomic Neuropathies, Hereditary Sensory Autonomic Neuropathy Type 1, Hereditary Sensory Autonomic Neuropathy Type 2, Hereditary Sensory Autonomic Neuropathy Type 4, Hereditary Sensory Autonomic Neuropathy Type 5, Hereditary Sensory Neuropathies, Hereditary Sensory Neuropathy, Hereditary Sensory Radicular Neuropathy, Hsan Hereditary Sensory Autonomic Neuropathy, Hsan Type I, Hsan Type Ii, Hsan Type Iis, Hsan Type Is, Hsan Type Iv, Hsan Type V, Hsans Hereditary Sensory Autonomic Neuropathy, Hsn Type I, Hsn Type Ii, Hsn Type Iis, Hsn Type Is, Iis Hsan Type, Iis Hsn Type, Insensitivity To Pain With Anhidrosis Congenital, Is Hsan Type, Is Hsn Type, Neuropathies Hereditary Sensory, Neuropathies Hereditary Sensory Autonomic, Neuropathy Hereditary Sensory, Pain Insensitivity With Anhidrosis Congenital, Sensory Autonomic Neuropathies Hereditary, Sensory Neuropathies Hereditary, Sensory Neuropathy Hereditary, Type I Hsan, Type I Hsn, Type Ii Hsan, Type Ii Hsn, Type Iis Hsan, Type Iis Hsn, Type Is Hsan, Type Is Hsn, Type Iv Hsan, Type V Hsan
Pain Specific Yes
Documents 264
Hot Single Events 105
Hot Interactions 18

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported for Hsan. They are ordered first by their pain relevance and then by number of times they were reported for Hsan. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT260070 Binding of PHF2 and SPTLC1 1 0.17 1.93 0.1 100.00
2 INT157214 Binding of SGCG and SPTLC2 1 0.14 0.68 0.22 99.98
3 INT157213 Binding of AGXT and SGCG 1 0.30 0.68 0.22 99.98
4 INT157215 Binding of SGCG and SPTLC1 1 0.32 0.67 0.22 99.98
5 INT98906 Positive_regulation of Binding of NTRK1 and PKLR 1 0.56 1.95 1.18 99.82
6 INT157211 Binding of AGXT and WNK1 1 0.07 0.68 0.22 99.82
7 INT157212 Binding of SPTLC1 and WNK1 1 0.07 0.67 0.22 99.82
8 INT157216 Binding of SPTLC2 and WNK1 1 0.03 0.68 0.22 99.82
9 INT98908 Binding of NTRK1 and PKLR 1 0.41 1.95 1.18 99.48
10 INT120870 Binding of Wnk1 and Sptlc1 1 0.14 1.24 0.56 99.08
11 INT84921 Binding of NGF and NTRK1 13 0.50 6.39 6.1 98.72
12 INT82023 Binding of Ntrk1 and Ngf 5 0.53 3.48 3.92 98.72
13 INT155610 FPR1 Positive_regulation of Phosphorylation of SGSM3 1 0.04 0.68 0.71 96.44
14 INT111909 Binding of HSPD1 and CCT4 1 0.29 0.48 0.25 90.44
15 INT111908 Binding of HSPD1 and AP4B1 1 0.03 0.48 0.25 90.44
16 INT110834 Binding of AGXT and SPTLC2 2 0.27 0.71 0.36 89.76
17 INT110835 Binding of SPTLC2 and SPTLC1 2 0.42 1.36 0.68 87.88
18 INT118980 NTRK1 Positive_regulation of NGF 1 0.56 1.45 1.39 80.12
19 INT131462 NGF Regulation of Localization of INS 1 0.40 0.97 1.2 75.00
20 INT131463 NTRK1 Regulation of Localization of INS 1 0.41 0.63 0.8 75.00
21 INT229785 Binding of RAB7A and SPTLC1 1 0.40 1.5 0.27 75.00
22 INT118979 NGF Positive_regulation of Phosphorylation of NTRK1 1 0.56 0.67 0.67 69.96
23 INT135641 Binding of Dst and Ina 1 0.35 0.34 0.06 59.56
24 INT110836 Binding of AGXT and SPTLC1 1 0.30 0.11 0 48.80
25 INT341336 Binding of Pepd and Nav1 1 0.07 0.92 1.3 5.00
26 INT341479 Binding of SCN2A and SCN4A 1 0.37 1.29 0.98 5.00
27 INT341480 Binding of SCN1A and SCN4A 1 0.36 1.29 0.98 5.00
28 INT260071 Binding of FANCC and XPA 1 0.24 0.76 0 5.00
29 INT260066 Binding of PHF2 and XPA 1 0.20 1.04 0 5.00
30 INT340916 hop Regulation of Dnahc8 1 0.02 0.24 0 5.00
31 INT340914 Binding of Hsp90aa1 and Fkbp6 1 0.12 0.26 0 5.00
32 INT260069 Binding of FANCC and PHF2 1 0.28 0.37 0 5.00
33 INT340919 Binding of Fkbp8 and Ptplad1 1 0.14 0.17 0 5.00
34 INT340913 Fkbp6 Negative_regulation of Binding of Hsp90aa1 1 0.14 0.26 0 5.00
35 INT260074 Binding of BRCA2 and PTCH1 1 0.40 0.15 0 5.00
36 INT340917 Binding of Ptges3 and Ptplad1 1 0.14 0.17 0 5.00
37 INT340915 Binding of Hsp90aa1 and Ptplad1 1 0.12 0.17 0 5.00
38 INT260073 Binding of FANCC and PTCH1 1 0.33 0.49 0 5.00
39 INT260067 Binding of PTCH1 and XPA 1 0.26 1.08 0 5.00
40 INT260072 Binding of BRCA2 and FANCC 1 0.37 0.63 0 5.00

Single Events

The table below shows the top 200 pain related interactions that have been reported for Hsan. They are ordered first by their pain relevance and then by number of times they were reported in Hsan. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT91100 Binding of SPTLC1 10 0.47 12.85 5.71 100.00
2 INT66041 Positive_regulation of NTRK1 24 0.70 16.12 8.42 100.00
3 INT229788 Negative_regulation of SPTLC1 1 0.38 4.82 3.53 100.00
4 INT81955 Positive_regulation of SPTLC1 12 0.70 10.25 3.12 100.00
5 INT77246 Positive_regulation of WNK1 5 0.10 4.24 1.13 100.00
6 INT80338 Gene_expression of SPTLC1 10 0.78 4.06 1.09 100.00
7 INT229786 Transcription of SPTLC1 1 0.60 0.78 0.71 100.00
8 INT80335 Localization of SPTLC1 4 0.75 0.61 0.65 100.00
9 INT77247 Binding of WNK1 5 0.46 3.45 0.7 100.00
10 INT66038 Positive_regulation of Ngfr 32 0.69 26.07 11.75 100.00
11 INT66039 Positive_regulation of Ntrk2 53 0.69 15.87 17.23 100.00
12 INT66040 Positive_regulation of Bdnf 114 0.69 67.67 51.81 100.00
13 INT90171 Positive_regulation of HNB1 1 0.00 0.57 0.32 100.00
14 INT3364 Binding of SGCG 87 0.47 31.93 17.24 100.00
15 INT121110 Binding of neuropathy type 1 1 0.01 0.66 0.33 100.00
16 INT90170 Regulation of HNB1 1 0.00 0.56 0.29 100.00
17 INT85047 Positive_regulation of Negative_regulation of NTRK1 3 0.47 2.13 1.3 99.96
18 INT71151 Regulation of NTRK1 10 0.62 6.65 6.21 99.84
19 INT70825 Positive_regulation of NINJ1 2 0.70 1.71 1.11 99.84
20 INT135640 Negative_regulation of Dst 5 0.57 2.25 1.56 99.84
21 INT5017 Negative_regulation of Tacr1 76 0.58 17 57.07 99.84
22 INT71152 Negative_regulation of NTRK1 15 0.59 10.28 5.5 99.82
23 INT90168 Regulation of Wnk1 2 0.04 0.63 0.29 99.82
24 INT109396 Negative_regulation of RET 12 0.42 14.92 1.06 99.82
25 INT93110 Regulation of CDCP1 16 0.03 7.98 3.83 99.80
26 INT85046 Positive_regulation of Positive_regulation of NTRK1 2 0.50 0.63 1.51 99.78
27 INT48313 Binding of NTRK1 19 0.47 14.44 6.12 99.76
28 INT93109 Phosphorylation of NTRK1 5 0.80 3.22 2.99 99.74
29 INT79737 Positive_regulation of Ntrk1 12 0.49 3.98 6.24 99.44
30 INT135637 Regulation of Dst 3 0.44 1.03 0.2 99.44
31 INT75626 Positive_regulation of Dst 2 0.50 0.52 0.23 99.44
32 INT72870 Negative_regulation of SPTLC2 7 0.57 1.82 1.73 99.40
33 INT86670 Negative_regulation of AGXT 6 0.57 2.24 1.18 99.36
34 INT19360 Positive_regulation of AGXT 2 0.69 1.4 0.32 99.36
35 INT100440 Negative_regulation of Positive_regulation of AGXT 1 0.02 0.23 0.23 99.36
36 INT81750 Regulation of Ntrk1 13 0.52 6.03 4.37 99.28
37 INT50970 Positive_regulation of Ntrk1 51 0.57 29.38 22.83 99.26
38 INT72298 Localization of Xpa 1 0.08 0.73 0.29 99.12
39 INT72299 Gene_expression of Xpa 1 0.07 0.73 0.29 99.12
40 INT72296 Localization of Gas1 1 0.50 0.73 0.29 99.12
41 INT72297 Gene_expression of Gas1 1 0.48 0.73 0.29 99.12
42 INT71153 Regulation of Negative_regulation of NTRK1 1 0.27 0.29 0.37 99.08
43 INT85048 Regulation of NGF 19 0.62 11.61 10.5 99.00
44 INT80339 Gene_expression of PHF2 3 0.73 2.3 0.26 99.00
45 INT80337 Localization of PHF2 1 0.70 0.1 0.1 99.00
46 INT3252 Negative_regulation of INS 428 0.59 271.65 39.52 98.92
47 INT63769 Regulation of Ngf 44 0.62 21.82 25.84 98.52
48 INT70826 Localization of NINJ1 4 0.75 2.17 1.1 98.44
49 INT66042 Positive_regulation of SPTLC2 2 0.68 0.97 0.66 98.44
50 INT110838 Regulation of AGXT 5 0.46 2.21 1.28 98.06
51 INT66941 Localization of NTRK1 8 0.78 5.89 1.96 97.80
52 INT80821 Gene_expression of Gpr176 1 0.32 0.7 3.97 97.56
53 INT23937 Gene_expression of EDNRA 103 0.65 55.63 24.67 97.56
54 INT78981 Regulation of Ntrk1 6 0.44 3.89 4.52 97.52
55 INT229792 Negative_regulation of Positive_regulation of RAB7A 1 0.40 1.49 1.17 97.48
56 INT229793 Negative_regulation of Positive_regulation of SPTLC1 1 0.43 1.49 1.17 97.48
57 INT229794 Positive_regulation of RAB7A 2 0.65 11.68 1.31 96.96
58 INT85233 Localization of SGSM3 11 0.78 10.91 3.41 96.76
59 INT229791 Gene_expression of RAB7A 2 0.73 6.48 1.21 96.72
60 INT66043 Regulation of SPTLC2 3 0.44 1.62 1.09 96.56
61 INT87644 Phosphorylation of SGSM3 12 0.80 2.08 7.04 96.44
62 INT100009 Phosphorylation of FPR1 3 0.38 1.02 1.9 96.16
63 INT80817 Localization of Gpr176 1 0.33 0.17 0.49 96.04
64 INT62688 Binding of Wnk1 2 0.17 2.83 0.63 95.32
65 INT93111 Phosphorylation of NGF 1 0.49 0.61 0.73 95.12
66 INT121918 Binding of Rab7 1 0.34 0.64 0.09 94.40
67 INT94144 Localization of ZDHHC2 2 0.13 0.59 0.26 94.08
68 INT94145 Gene_expression of ZDHHC2 1 0.12 0.17 0.17 94.08
69 INT46350 Gene_expression of Msr1 32 0.65 29.39 4.55 94.00
70 INT48312 Gene_expression of NTRK1 72 0.78 38.21 22.24 93.80
71 INT60286 Gene_expression of PKLR 5 0.65 2.14 1.04 93.80
72 INT71150 Binding of NGF 22 0.46 13.67 14.81 93.28
73 INT99970 Regulation of Binding of NGF 2 0.27 2.35 1.93 93.28
74 INT52344 Localization of NTRK2 2 0.81 0.56 0.3 92.12
75 INT62610 Phosphorylation of Ntrk1 5 0.56 1.64 2.68 91.52
76 INT99344 Positive_regulation of Transcription of Sptlc2 1 0.19 0.36 0.19 91.20
77 INT99346 Transcription of Sptlc2 1 0.20 0.36 0.19 91.20
78 INT23435 Positive_regulation of NGF 54 0.70 32.41 30.11 90.64
79 INT129020 Phosphorylation of Ntrk1 17 0.80 5.97 6.37 90.56
80 INT77887 Negative_regulation of Spt 7 0.50 3.9 0.54 90.48
81 INT103766 Positive_regulation of Phosphorylation of DDR1 2 0.13 1.94 1.19 90.08
82 INT103767 Phosphorylation of DDR1 6 0.20 4.67 1.56 89.12
83 INT98392 Positive_regulation of Spt 6 0.39 2.35 0.54 88.88
84 INT83411 Binding of Ntrk1 6 0.19 3.7 3.74 88.84
85 INT157219 Gene_expression of WNK1 4 0.58 2.5 0.28 88.60
86 INT80818 Transcription of Gpr176 1 0.29 0.53 3.38 87.84
87 INT158326 Phosphorylation of Tie1 1 0.16 0.8 0.45 87.84
88 INT99345 Regulation of Spt 1 0.18 0.36 0.19 87.12
89 INT75628 Gene_expression of Dst 4 0.60 0.78 0.31 87.00
90 INT110837 Binding of SPTLC2 1 0.36 0.7 0.35 86.64
91 INT135639 Gene_expression of Ina 3 0.76 9.58 2.89 86.36
92 INT85049 Negative_regulation of Positive_regulation of NTRK1 1 0.59 0.56 0.64 86.32
93 INT44717 Gene_expression of TNFSF14 12 0.75 13.44 3.72 86.24
94 INT12265 Positive_regulation of IgG 168 0.63 104.89 19.76 84.08
95 INT46221 Positive_regulation of Gene_expression of IgG 46 0.53 33.66 7.7 84.08
96 INT4509 Gene_expression of IgG 426 0.76 293.69 56.64 84.08
97 INT229790 Regulation of Gene_expression of AGXT 1 0.11 0.47 0.24 83.48
98 INT586 Positive_regulation of Lipa 2 0.64 1.69 0.28 83.48
99 INT229789 Regulation of RAB7A 4 0.42 7.09 0.72 83.04
100 INT70823 Negative_regulation of NINJ1 1 0.43 0.93 0.23 82.80
101 INT21632 Positive_regulation of Adh1 32 0.70 15.67 11.65 82.52
102 INT229787 Gene_expression of AGXT 4 0.16 0.94 1.08 82.40
103 INT183055 Gene_expression of PTCH1 10 0.77 15.54 0.26 80.40
104 INT158754 Gene_expression of XPA 3 0.57 4.24 0.2 80.40
105 INT238184 Gene_expression of FANCC 6 0.60 2.92 0.19 80.40
106 INT129848 Negative_regulation of CD5 3 0.42 3.01 0.67 79.76
107 INT341482 Gene_expression of NMNAT1 1 0.01 3.24 2.79 79.52
108 INT70824 Gene_expression of NINJ1 4 0.78 2.67 0.61 78.64
109 INT111913 Negative_regulation of CCT4 1 0.31 0.41 0.22 77.12
110 INT111912 Negative_regulation of TAP1 1 0.04 0.41 0.22 77.12
111 INT111910 Negative_regulation of Positive_regulation of CCT4 1 0.31 0.41 0.22 76.72
112 INT111911 Positive_regulation of CCT4 1 0.36 0.41 0.22 76.72
113 INT812 Localization of INS 1026 0.81 515.6 145.31 75.00
114 INT28673 Gene_expression of APOB 51 0.73 34.02 3.95 75.00
115 INT251 Regulation of INS 398 0.62 232.47 55.04 75.00
116 INT157220 Negative_regulation of Binding of AGXT 1 0.28 0.7 0.19 75.00
117 INT81752 Binding of BPIFA4P 8 0.37 2.87 0.29 75.00
118 INT94146 Regulation of SPTLC1 2 0.51 2.39 0.36 75.00
119 INT157217 Binding of AGXT 1 0.23 0.69 0.19 75.00
120 INT77248 Localization of OSCP1 1 0.58 0.57 0.17 75.00
121 INT157218 Gene_expression of C1orf133 1 0.01 0.66 0.17 75.00
122 INT80819 Binding of Gpr176 2 0.15 0.41 0.96 75.00
123 INT3253 Negative_regulation of Localization of INS 205 0.59 130.39 36.61 75.00
124 INT2274 Regulation of Localization of INS 101 0.62 41.55 34.79 75.00
125 INT20216 Localization of NGF 40 0.80 18.16 16.61 75.00
126 INT70905 Positive_regulation of EDNRA 49 0.67 24.33 11.79 75.00
127 INT80822 Positive_regulation of MRGPRX1 30 0.67 3.66 7.73 75.00
128 INT80820 Positive_regulation of Gpr176 1 0.20 0.07 0.26 75.00
129 INT8621 Gene_expression of Padi4 3 0.52 0.76 0.15 75.00
130 INT91099 Gene_expression of MFN2 2 0.67 1.32 0.07 75.00
131 INT131835 Positive_regulation of Wnk1 1 0.07 1.28 0.07 75.00
132 INT91101 Gene_expression of GARS 1 0.32 0.95 0.07 75.00
133 INT80405 Gene_expression of Gnptab 7 0.06 0.52 4.03 74.24
134 INT5374 Gene_expression of Esr1 412 0.77 263.89 67.34 73.84
135 INT17237 Regulation of Esr1 74 0.43 49.09 17.25 71.80
136 INT116763 Gene_expression of IKBKAP 63 0.78 54.53 0.79 71.00
137 INT37296 Binding of Esr1 117 0.43 62.51 27.33 69.36
138 INT118981 Positive_regulation of Phosphorylation of NTRK1 1 0.49 0.66 0.66 69.12
139 INT102649 Binding of FRA7G 1 0.23 1.38 0.25 68.72
140 INT135638 Binding of Dst 4 0.36 2.76 0.38 66.40
141 INT129679 Negative_regulation of Hsf1 9 0.43 3.22 0.22 66.08
142 INT340887 Negative_regulation of Hsbp1 1 0.28 0.37 0.07 66.08
143 INT129678 Gene_expression of Hsf1 13 0.78 8.57 0.85 65.32
144 INT115615 Regulation of SCA25 1 0.36 0.56 0.07 65.20
145 INT340884 Gene_expression of Hsbp1 1 0.39 0.37 0.06 64.40
146 INT30886 Positive_regulation of Ina 5 0.62 1.35 0.96 62.64
147 INT37351 Negative_regulation of IKBKAP 16 0.58 9.6 0.56 62.40
148 INT153430 Binding of Elane 2 0.47 1.92 0.48 60.60
149 INT262317 Binding of TAF9 7 0.31 9.67 2.15 59.60
150 INT135635 Binding of Ina 2 0.41 8.28 0.88 59.56
151 INT252999 Gene_expression of TAF9 12 0.75 12.65 2.92 56.00
152 INT75627 Gene_expression of Mapt 41 0.75 22.1 4.58 55.16
153 INT75629 Gene_expression of Mtap2 41 0.66 8.19 4.51 55.16
154 INT62199 Binding of Hsf1 12 0.45 10.77 0.6 55.12
155 INT135636 Negative_regulation of Positive_regulation of Ina 1 0.38 0.33 0.05 54.56
156 INT55309 Positive_regulation of Ssr1 20 0.46 5.97 5.74 50.00
157 INT55310 Gene_expression of Ssr1 20 0.67 3.47 2.56 50.00
158 INT81956 Positive_regulation of Protein_catabolism of SPTLC1 1 0.06 0.16 0 50.00
159 INT81957 Protein_catabolism of SPTLC1 1 0.10 0.15 0 50.00
160 INT63349 Gene_expression of PECAM1 199 0.75 166.03 36.76 49.40
161 INT260080 Negative_regulation of Gene_expression of PTCH1 1 0.58 2.09 0 46.40
162 INT340899 Gene_expression of Hspe1 2 0.53 0.75 0 45.20
163 INT73981 Gene_expression of Hspd1 18 0.75 5.69 3.72 44.64
164 INT75625 Localization of Dst 1 0.75 0.15 0.13 44.52
165 INT93778 Positive_regulation of Gnptab 2 0.02 0.32 1.47 41.20
166 INT271910 Gene_expression of Hsf2 4 0.45 1.63 0 40.64
167 INT340896 Regulation of Hsf2 1 0.18 0.54 0 40.64
168 INT217067 Regulation of Positive_regulation of MAPK8 7 0.45 3.09 0.43 40.16
169 INT80690 Positive_regulation of MAPK8 223 0.68 125.63 36.75 39.20
170 INT205968 Negative_regulation of PTCH1 2 0.58 2.35 0 19.84
171 INT46460 Gene_expression of NAV1 288 0.78 135.51 305.75 5.00
172 INT94450 Gene_expression of Nav1 359 0.78 131.85 275.46 5.00
173 INT85640 Gene_expression of Tg(CAG-EGFP)D4Nagy 1138 0.72 311.58 119.18 5.00
174 INT654 Localization of REN 250 0.81 75.12 47.86 5.00
175 INT111051 Negative_regulation of Nav1 64 0.59 25.51 47.27 5.00
176 INT103261 Positive_regulation of Nav1 68 0.70 24.25 39.27 5.00
177 INT116321 Regulation of Nav1 38 0.62 26.62 37.97 5.00
178 INT111052 Positive_regulation of Gene_expression of Nav1 44 0.70 18.98 35.28 5.00
179 INT103262 Localization of Nav1 53 0.81 19.23 34.44 5.00
180 INT111050 Negative_regulation of Gene_expression of Nav1 23 0.58 5.97 17.06 5.00
181 INT113384 Regulation of Gene_expression of Nav1 20 0.62 8.57 16.15 5.00
182 INT112207 Binding of Nav1 27 0.47 7.1 15.43 5.00
183 INT1556 Regulation of Dnahc8 20 0.61 3.23 14.44 5.00
184 INT91703 Negative_regulation of Myoz1 78 0.58 53.78 13.5 5.00
185 INT2038 Localization of Esr1 104 0.79 40.12 13.27 5.00
186 INT113490 Gene_expression of SCN9A 22 0.77 5.45 12.27 5.00
187 INT108384 Binding of Ntrk1 28 0.39 10.73 9.09 5.00
188 INT67037 Gene_expression of Sod1 121 0.78 59.32 7.99 5.00
189 INT103518 Negative_regulation of SCN2A 17 0.57 8.4 5.4 5.00
190 INT23598 Binding of SCN5A 32 0.40 16 5.35 5.00
191 INT58435 Gene_expression of Hspa1a 19 0.78 15.35 4.45 5.00
192 INT45725 Binding of Pdia3 8 0.47 3.61 4.42 5.00
193 INT119063 Gene_expression of BRCA1 24 0.67 30.04 4.17 5.00
194 INT252968 Positive_regulation of TAF9 11 0.45 5.28 3.68 5.00
195 INT111053 Positive_regulation of Positive_regulation of Nav1 4 0.46 2.97 3.53 5.00
196 INT14281 Gene_expression of Hspa5 44 0.63 34.19 3.31 5.00
197 INT117121 Gene_expression of Hspa8 7 0.65 4.92 2.94 5.00
198 INT85767 Gene_expression of Scn9a 11 0.76 9.27 2.74 5.00
199 INT128928 Gene_expression of Hspb2 15 0.76 9.42 2.52 5.00
200 INT222088 Gene_expression of Dnajb1 11 0.65 3.37 2.18 5.00
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