P:Hyperesthesia

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Pain Term
Category Pain type
Synonyms Hyperaesthesia
Pain Specific Yes
Documents 1137
Hot Single Events 51
Hot Interactions 2

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported for Hyperesthesia. They are ordered first by their pain relevance and then by number of times they were reported for Hyperesthesia. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT321602 Binding of C4A and PRTN3 1 0.00 0.99 0.27 87.28
2 INT321601 Binding of C3 and PRTN3 1 0.00 0.99 0.27 86.96
3 INT154187 Il6 Positive_regulation of Gene_expression of Cd2 1 0.08 3.07 2.71 25.00
4 INT154188 Il6 Positive_regulation of Gene_expression of Atf3 1 0.76 3.07 2.71 25.00
5 INT126400 ITIH4 Positive_regulation of Gene_expression of Il6 1 0.00 2.11 2.08 25.00
6 INT126401 ITIH4 Positive_regulation of Gene_expression of Ptgs2 1 0.00 1.05 1.04 25.00
7 INT150733 Negative_regulation of Tlr3 Negative_regulation of Positive_regulation of Il1b 1 0.48 1.34 0.83 25.00
8 INT29057 Gtf3a Negative_regulation of Ns5atp9 1 0.13 0.51 0.28 25.00
9 INT261831 Mapk1 Negative_regulation of Hspg2 1 0.00 1.26 1.42 5.00
10 INT261841 Mastl Positive_regulation of Trpa1 1 0.00 0.82 1.3 5.00
11 INT261834 Itpr3 Positive_regulation of Prkca 2 0.01 0.33 0.78 5.00
12 INT261845 NGF Positive_regulation of Trpa1 1 0.04 0.73 0.71 5.00
13 INT261835 Camk2a Positive_regulation of Prkca 1 0.01 0.32 0.66 5.00
14 INT261832 Trpv1 Negative_regulation of Trpa1 1 0.10 0.58 0.64 5.00
15 INT261830 Hspg2 Negative_regulation of Trpa1 1 0.01 0.58 0.63 5.00
16 INT261828 Igf1 Regulation of Localization of Trpv2 1 0.02 1.04 0.58 5.00
17 INT261839 Binding of Car2 and Trpv1 1 0.03 0 0.45 5.00
18 INT261842 Pla2g6 Positive_regulation of Trpm8 1 0.03 0 0.23 5.00
19 INT240119 Prok2 Regulation of Trem1 1 0.04 0.66 0.13 5.00
20 INT240121 Hdc Regulation of Trem1 1 0.06 0.66 0.13 5.00
21 INT240120 Irg1 Regulation of Trem1 1 0.05 0.66 0.13 5.00
22 INT295005 Binding of TNFRSF11A and Tnfsf11 3 0.20 2.02 0.09 5.00
23 INT295003 Binding of Tnfrsf11b and Tnfsf11 3 0.22 1.85 0.08 5.00
24 INT320659 Vsig2 Positive_regulation of Transcription of Nos2 1 0.07 0.65 0.07 5.00
25 INT321891 Dkk1 Negative_regulation of Wnt2 1 0.12 0.94 0.05 5.00
26 INT295006 Binding of TNFRSF11A and Tnfrsf11b 2 0.10 1.6 0.04 5.00
27 INT321890 Slc3a2 Regulation of Dkk1 1 0.01 0.93 0.04 5.00
28 INT240122 Nab2 Regulation of Egr1 1 0.09 0.59 0 5.00
29 INT261833 Binding of Add3 and Trpv4 1 0.00 0.12 0 5.00
30 INT261838 Lyn Regulation of Trpv4 1 0.03 0.19 0 5.00
31 INT261840 Binding of Mtap7 and Trpv4 1 0.05 0.12 0 5.00
32 INT261843 Lyn Regulation of Regulation of Trpv4 1 0.03 0.19 0 5.00
33 INT261844 Lyn Positive_regulation of Lyn Regulation of Trpv4 1 0.01 0.19 0 5.00
34 INT261837 Binding of Aqp5 and Trpv4 1 0.05 0.17 0 5.00

Single Events

The table below shows the top 200 pain related interactions that have been reported for Hyperesthesia. They are ordered first by their pain relevance and then by number of times they were reported in Hyperesthesia. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT51180 Regulation of Nkx2-2 5 0.26 2.16 4.14 100.00
2 INT7039 Regulation of Nkx1-1 22 0.44 10.51 20.89 100.00
3 INT109432 Negative_regulation of Phosphorylation of Mapk1 19 0.54 7.01 8.98 100.00
4 INT94952 Positive_regulation of Mapk14 305 0.70 197.83 186.61 100.00
5 INT76660 Gene_expression of Trpv1 691 0.78 329.46 386.42 100.00
6 INT5591 Regulation of Gene_expression of Fos 425 0.62 129.06 265.78 100.00
7 INT63932 Positive_regulation of Ephb1 537 0.70 259.67 296.14 100.00
8 INT11012 Positive_regulation of Creb1 258 0.70 84.4 132 100.00
9 INT25915 Negative_regulation of RPL7AP5 9 0.38 3.56 8.5 100.00
10 INT52692 Gene_expression of Ptgs2 160 0.78 85.06 55.73 100.00
11 INT22700 Positive_regulation of Gene_expression of Tac1 13 0.69 6.89 8.2 99.90
12 INT109434 Phosphorylation of Mapk1 110 0.82 61.64 34.05 99.76
13 INT5505 Regulation of Localization of Pomc 54 0.61 6.96 30.77 99.72
14 INT4742 Gene_expression of Tac1 177 0.78 69.99 102.66 99.70
15 INT18357 Gene_expression of TRPV1 825 0.78 307.11 382.81 99.70
16 INT121884 Regulation of Binding of Nos1 2 0.33 1.63 2.15 99.60
17 INT31742 Negative_regulation of RPL7AP7 3 0.54 1.19 3.07 99.48
18 INT87607 Positive_regulation of Prkcc 25 0.69 6.06 22.78 99.40
19 INT29056 Regulation of Gene_expression of Alox5 4 0.60 1.47 0.72 99.38
20 INT23344 Gene_expression of Alox5 60 0.75 28.2 13.82 99.22
21 INT5200 Gene_expression of Fos 3083 0.78 894.43 1639.02 99.18
22 INT1308 Localization of Pomc 457 0.81 66.83 217.5 99.18
23 INT48895 Gene_expression of Il10 333 0.78 221.2 138.52 98.88
24 INT240105 Negative_regulation of Prok1 1 0.04 1.12 0.58 98.84
25 INT25057 Positive_regulation of Hmmr 14 0.28 5.09 9.63 98.60
26 INT5895 Gene_expression of Oprm1 525 0.78 120.67 407.29 98.36
27 INT6293 Gene_expression of Oprm1 312 0.78 48.73 215.61 98.36
28 INT23657 Positive_regulation of APP 64 0.70 39.76 16.68 98.00
29 INT49172 Regulation of Nos1 43 0.52 27.53 23.66 97.76
30 INT80251 Binding of Nos1 21 0.30 8.24 11.31 97.76
31 INT6385 Regulation of Man2a2 48 0.61 7.8 24.68 97.74
32 INT4509 Gene_expression of IgG 426 0.76 293.69 56.64 97.08
33 INT48767 Negative_regulation of NOS1 312 0.59 154.25 90.32 96.50
34 INT18489 Binding of Man2a2 59 0.48 11.27 29.38 95.20
35 INT73128 Regulation of Pde5a 7 0.37 4.42 4.27 93.96
36 INT3987 Positive_regulation of IGHE 316 0.70 283.2 40.16 92.52
37 INT46643 Negative_regulation of HYAL1 7 0.37 4.65 1.55 92.24
38 INT8159 Binding of ELL 7 0.36 12.62 0.84 91.32
39 INT95207 Negative_regulation of Pde5a 46 0.58 32.01 10.14 90.96
40 INT7134 Localization of KNG1 127 0.79 65.73 67.97 89.56
41 INT16996 Gene_expression of PRTN3 113 0.75 85.61 22.57 89.12
42 INT756 Gene_expression of C3 138 0.75 100.6 19.2 89.12
43 INT45818 Gene_expression of C4A 35 0.75 26.4 3.52 89.12
44 INT102631 Localization of HYAL1 4 0.26 1.79 0.46 89.12
45 INT22707 Positive_regulation of Eno2 36 0.69 27.31 5.07 88.52
46 INT220273 Positive_regulation of Msu 9 0.33 5.83 1.41 85.80
47 INT61316 Gene_expression of Coq10a 59 0.73 32.81 3.95 83.72
48 INT4985 Positive_regulation of Tac1 81 0.69 35.79 50.67 83.52
49 INT148638 Protein_catabolism of Hpse 1 0.48 1.09 1.28 81.28
50 INT613 Gene_expression of Alb 268 0.78 149.84 42.78 80.88
51 INT4422 Positive_regulation of Gene_expression of Alb 30 0.50 18.56 6.12 80.88
52 INT49170 Negative_regulation of Nos1 116 0.59 60.66 58.87 79.72
53 INT11021 Gene_expression of Tme 12 0.52 8.54 0.33 78.40
54 INT15201 Positive_regulation of CHRM1 8 0.54 2.14 2.35 77.76
55 INT749 Gene_expression of HLA-B 341 0.75 224.12 77.37 77.56
56 INT80420 Gene_expression of IFI27 145 0.78 63.61 8.83 76.48
57 INT62336 Positive_regulation of Hdc 38 0.70 14.45 5.51 76.20
58 INT87181 Gene_expression of Abo 4 0.57 2.81 1.19 74.92
59 INT1254 Gene_expression of Dut 2 0.65 1.71 1.02 73.76
60 INT27446 Negative_regulation of CTSA 11 0.57 5.58 3.08 72.56
61 INT63719 Positive_regulation of Transcription of Hdc 3 0.52 3.91 1.01 72.04
62 INT63716 Transcription of Hdc 10 0.69 7.57 1.82 71.72
63 INT9658 Negative_regulation of Gene_expression of Il6 110 0.59 66.29 32.58 70.96
64 INT9659 Gene_expression of Il6 991 0.78 715.11 265.57 70.40
65 INT1603 Negative_regulation of Rtcd1 131 0.51 29.99 66.66 69.56
66 INT117561 Positive_regulation of Transcription of Tac1 6 0.69 3.19 3.78 69.32
67 INT4723 Transcription of Tac1 26 0.71 8.33 11.18 68.92
68 INT4984 Positive_regulation of Positive_regulation of Tac1 11 0.50 5.34 8.73 67.80
69 INT191589 Gene_expression of Msu 9 0.46 7.08 1.33 66.72
70 INT70265 Regulation of MRI1 42 0.39 30.95 14.18 63.96
71 INT17349 Negative_regulation of Akr1b1 41 0.59 27.03 10.65 63.04
72 INT13415 Positive_regulation of Hpse 58 0.70 24.9 25.53 62.80
73 INT6063 Positive_regulation of Bche 17 0.66 6.07 3.08 62.60
74 INT163980 Gene_expression of Hdc 12 0.65 4.47 1.96 62.00
75 INT3364 Binding of SGCG 87 0.47 31.93 17.24 61.28
76 INT220276 Negative_regulation of Msu 2 0.16 1.67 0.58 58.08
77 INT7340 Regulation of Grin1 87 0.62 30.37 57.93 57.68
78 INT49009 Regulation of Trpc3 2 0.26 0.29 0.99 57.68
79 INT374 Positive_regulation of Ldha 212 0.70 107.08 47.43 57.64
80 INT222847 Gene_expression of Irg1 2 0.49 2.38 0.51 55.04
81 INT7341 Positive_regulation of Grin1 169 0.70 65.86 118.38 54.72
82 INT23147 Negative_regulation of MRI1 26 0.38 14.33 8.96 54.28
83 INT148639 Gene_expression of Uchl1 30 0.59 16.76 11.54 50.88
84 INT2229 Positive_regulation of Man2a2 50 0.69 7.47 30.33 50.00
85 INT27596 Negative_regulation of Positive_regulation of Man2a2 4 0.42 0.47 1.78 50.00
86 INT81229 Binding of COL1A1 24 0.35 12.07 3.3 48.64
87 INT52194 Positive_regulation of Grin1 83 0.69 25.09 34.76 47.24
88 INT224149 Negative_regulation of Trem1 2 0.37 3.44 0.56 44.60
89 INT320654 Negative_regulation of Localization of Vsig2 1 0.24 0.75 0.17 41.48
90 INT7147 Localization of Vsig2 7 0.49 4.42 0.86 40.92
91 INT240115 Regulation of Positive_regulation of Msu 1 0.17 0.5 0.03 39.92
92 INT240110 Positive_regulation of Positive_regulation of Trem1 1 0.25 0.9 0.19 39.84
93 INT146142 Positive_regulation of Trem1 11 0.44 7.75 1.46 39.36
94 INT6483 Gene_expression of TNF 3152 0.78 2515.62 929.82 38.08
95 INT64816 Transcription of Jun 31 0.69 16.01 7.64 36.76
96 INT53475 Gene_expression of MRI1 116 0.59 77.68 33.98 34.20
97 INT144292 Binding of Ppt1 9 0.37 2.02 1.71 33.84
98 INT73431 Positive_regulation of Nos3 82 0.65 53.22 11.61 31.80
99 INT79093 Positive_regulation of Nos1 101 0.70 46.89 59.61 31.48
100 INT39972 Gene_expression of CPA1 7 0.65 3.17 0.26 31.44
101 INT8243 Positive_regulation of Il6 451 0.70 358.24 119.28 31.32
102 INT91013 Binding of IFNAR1 9 0.46 8.7 2.74 27.60
103 INT34370 Positive_regulation of Cfp 26 0.46 15.21 6.12 26.40
104 INT61845 Transcription of Homer1 9 0.72 2.28 1.85 25.16
105 INT2542 Localization of Calca 2008 0.81 518.3 1408.65 25.00
106 INT1912 Gene_expression of Calca 1152 0.78 453.25 739.84 25.00
107 INT5202 Positive_regulation of Gene_expression of Fos 1163 0.70 319.28 684 25.00
108 INT2543 Positive_regulation of Calca 787 0.70 331.13 592.08 25.00
109 INT5228 Positive_regulation of Fos 934 0.70 209.8 503.87 25.00
110 INT4758 Positive_regulation of Localization of Calca 557 0.70 138.55 411.04 25.00
111 INT2540 Negative_regulation of Calca 538 0.59 172.11 384.38 25.00
112 INT6580 Negative_regulation of Ptgs1 929 0.59 381.53 376.26 25.00
113 INT2649 Regulation of Calca 433 0.62 146.05 330.95 25.00
114 INT4941 Positive_regulation of Oprd1 345 0.70 74.26 304.41 25.00
115 INT9158 Gene_expression of Tnf 722 0.78 522.01 277.68 25.00
116 INT5972 Gene_expression of IL1B 948 0.78 510.91 263.97 25.00
117 INT87687 Positive_regulation of Trpv1 409 0.70 210.24 257.59 25.00
118 INT16868 Gene_expression of Il6 807 0.78 499.48 256.57 25.00
119 INT11377 Positive_regulation of Ngf 331 0.70 206.5 238 25.00
120 INT4759 Negative_regulation of Localization of Calca 294 0.59 82.62 226.45 25.00
121 INT11009 Phosphorylation of Creb1 458 0.82 111.34 221.97 25.00
122 INT9132 Negative_regulation of Prkcg 279 0.59 88.05 203.47 25.00
123 INT11313 Positive_regulation of Il6 526 0.70 331.27 201.59 25.00
124 INT5050 Regulation of Localization of Calca 149 0.62 41.25 148.57 25.00
125 INT6108 Gene_expression of Npy 292 0.78 110.65 148.21 25.00
126 INT13353 Positive_regulation of Tnf 332 0.70 248.75 148.1 25.00
127 INT3300 Positive_regulation of Gene_expression of Calca 179 0.70 77.76 144.2 25.00
128 INT12501 Positive_regulation of Adarb1 166 0.58 36.94 118.92 25.00
129 INT4207 Regulation of Avp 267 0.62 63.72 115.33 25.00
130 INT11011 Positive_regulation of Phosphorylation of Creb1 190 0.70 49.25 112.01 25.00
131 INT49651 Gene_expression of Creb1 276 0.78 114.77 111.96 25.00
132 INT27096 Positive_regulation of Nfkb1 325 0.70 195.11 109.06 25.00
133 INT8413 Gene_expression of Ptgs1 248 0.78 110.17 108.58 25.00
134 INT10272 Gene_expression of Il1b 194 0.78 121.02 103.03 25.00
135 INT97701 Phosphorylation of Mapk14 191 0.82 115.33 100.46 25.00
136 INT94953 Negative_regulation of Mapk14 156 0.59 104.77 91.51 25.00
137 INT67682 Localization of Bdnf 204 0.81 72.36 88.92 25.00
138 INT82448 Gene_expression of S100a8 246 0.77 236.72 84.02 25.00
139 INT24958 Gene_expression of Nkx1-1 106 0.74 51.29 76.88 25.00
140 INT10274 Positive_regulation of Il1b 123 0.70 79.76 73.56 25.00
141 INT5969 Gene_expression of Il1a 221 0.75 96.31 71.38 25.00
142 INT14049 Positive_regulation of GRIN1 102 0.70 48.31 71.06 25.00
143 INT58400 Negative_regulation of Tnf 182 0.59 129.97 71 25.00
144 INT6849 Localization of IL1B 229 0.81 112.56 69.63 25.00
145 INT66416 Regulation of Pnoc 66 0.61 17.32 68.91 25.00
146 INT6486 Positive_regulation of Tnf 168 0.70 123.47 66.05 25.00
147 INT12175 Positive_regulation of PDYN 86 0.69 18.27 62.04 25.00
148 INT48934 Positive_regulation of Mapk1 157 0.70 60.61 61.72 25.00
149 INT6623 Gene_expression of NA 231 0.78 45.78 59.36 25.00
150 INT1307 Positive_regulation of Localization of Pomc 120 0.70 24.58 58.48 25.00
151 INT5356 Positive_regulation of FOS 153 0.69 54.21 56.74 25.00
152 INT20266 Positive_regulation of Bdkrb1 60 0.69 63.64 56.59 25.00
153 INT83602 Positive_regulation of Gene_expression of TRPV1 114 0.70 51.19 56.35 25.00
154 INT52800 Negative_regulation of Gene_expression of Tnf 142 0.59 92.27 55.47 25.00
155 INT8700 Positive_regulation of Positive_regulation of Calca 56 0.67 21.69 53.66 25.00
156 INT96914 Phosphorylation of Mapk14 168 0.82 108.46 53.32 25.00
157 INT48920 Negative_regulation of Ephb1 107 0.57 43.6 51.02 25.00
158 INT49520 Gene_expression of P2rx3 121 0.78 61.15 49.24 25.00
159 INT51163 Gene_expression of Gal 119 0.78 67.48 49.23 25.00
160 INT6823 Negative_regulation of Pdyn 68 0.58 13.95 46.12 25.00
161 INT88617 Positive_regulation of Gene_expression of Creb1 90 0.69 51.69 44.29 25.00
162 INT5307 Regulation of Tnf 87 0.62 78.71 43.4 25.00
163 INT52531 Gene_expression of Nfkb1 153 0.75 82.84 42.9 25.00
164 INT27798 Gene_expression of Ntrk2 111 0.78 56.08 42.68 25.00
165 INT9233 Negative_regulation of Gene_expression of IL1B 114 0.59 56.99 41.82 25.00
166 INT48075 Positive_regulation of Il1b 71 0.67 48.63 40.48 25.00
167 INT107576 Gene_expression of Atf3 114 0.78 72.42 38.64 25.00
168 INT11439 Positive_regulation of Csf2 105 0.69 62.63 37.77 25.00
169 INT84260 Positive_regulation of Mapk8 124 0.69 72.84 35.98 25.00
170 INT11013 Negative_regulation of Phosphorylation of Creb1 55 0.59 18.74 34.66 25.00
171 INT47710 Negative_regulation of GRIN1 71 0.57 25.57 34.24 25.00
172 INT7692 Positive_regulation of PENK 71 0.70 20.34 32.54 25.00
173 INT5069 Negative_regulation of Mthfs 69 0.57 22.54 31.36 25.00
174 INT5418 Negative_regulation of Alox5 108 0.57 42.09 31.17 25.00
175 INT9053 Negative_regulation of ALOX5 97 0.58 40.34 29.94 25.00
176 INT95481 Regulation of Gene_expression of TRPV1 48 0.62 29.3 26.28 25.00
177 INT5948 Regulation of Il1b 44 0.60 22.8 25.4 25.00
178 INT48248 Gene_expression of Scn10a 38 0.78 19.3 25.05 25.00
179 INT106272 Positive_regulation of Positive_regulation of Mapk14 39 0.70 32.08 24.71 25.00
180 INT9155 Gene_expression of Glul 60 0.77 17.97 23.95 25.00
181 INT37889 Gene_expression of P2ry2 75 0.65 26.01 23.8 25.00
182 INT129157 Positive_regulation of Atf3 48 0.69 35.42 22.87 25.00
183 INT12114 Positive_regulation of Tnfrsf1a 46 0.69 36.26 22.54 25.00
184 INT106175 Positive_regulation of Positive_regulation of Creb1 37 0.70 13.89 22.46 25.00
185 INT21503 Binding of Ptgs1 45 0.48 15.6 22.29 25.00
186 INT2911 Positive_regulation of Glul 36 0.70 11.09 22.07 25.00
187 INT50778 Gene_expression of Adrbk1 24 0.77 11.61 20.73 25.00
188 INT69877 Positive_regulation of Positive_regulation of Nfkb1 53 0.68 31.44 20.7 25.00
189 INT48144 Gene_expression of Fgf2 117 0.78 43 20.48 25.00
190 INT112930 Negative_regulation of Adrbk1 17 0.58 15.04 20.41 25.00
191 INT12265 Positive_regulation of IgG 168 0.63 104.89 19.76 25.00
192 INT104527 Binding of FSCN1 18 0.23 14.75 19.6 25.00
193 INT66755 Transcription of Tnf 45 0.72 37.1 19.11 25.00
194 INT69592 Positive_regulation of PSMD1 27 0.70 17.83 18.98 25.00
195 INT61158 Negative_regulation of Creb1 33 0.59 11.54 18.06 25.00
196 INT82531 Positive_regulation of Gene_expression of Gal 41 0.69 28.67 18.04 25.00
197 INT151747 Positive_regulation of PSMD2 26 0.68 17.48 17.89 25.00
198 INT111531 Negative_regulation of Phosphorylation of Mapk14 37 0.50 20 17.68 25.00
199 INT105197 Negative_regulation of GTS 14 0.37 3.88 17.14 25.00
200 INT48892 Transcription of Il10 31 0.71 27.26 16.77 25.00
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