P:Leflunomide

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pChart

Pain Term
Category Drug
Synonyms None
Pain Specific No
Documents 228
Hot Single Events 200
Hot Interactions 8

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported for Leflunomide. They are ordered first by their pain relevance and then by number of times they were reported for Leflunomide. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT278697 LEF1 Negative_regulation of STAT6 1 0.00 0.44 0.78 100.00
2 INT278690 LEF1 Negative_regulation of Gene_expression of IK 1 0.00 0.66 0.83 100.00
3 INT278696 MTX1 Negative_regulation of Gene_expression of IK 1 0.00 0.66 0.83 99.96
4 INT222923 Negative_regulation of Pde4a Negative_regulation of Positive_regulation of Mpo 1 0.04 0.59 0.45 99.96
5 INT222924 Negative_regulation of Pde4a Negative_regulation of Gene_expression of Il12a 1 0.01 0.59 0.45 99.96
6 INT138602 Negative_regulation of BCL2L2 Positive_regulation of F2 1 0.00 0.67 0.92 96.72
7 INT138601 BCL2L2 Positive_regulation of F2 1 0.00 0.66 0.91 96.50
8 INT222922 Negative_regulation of Pde4a Negative_regulation of Gene_expression of Il1 1 0.01 0.56 0.44 88.88
9 INT287819 Binding of CD80 and Cd28 1 0.25 0.7 0.4 76.92
10 INT287818 Negative_regulation of Binding of CD80 and Cd28 1 0.29 0.7 0.4 76.92
11 INT239037 Binding of Cd28 and Cd86 9 0.16 3.69 2.14 76.28
12 INT239038 Negative_regulation of Binding of Cd28 and Cd86 3 0.17 1.5 1.05 76.28
13 INT278691 MTX1 Negative_regulation of DHFR 1 0.02 0.57 0.49 72.80
14 INT162500 AHR Regulation of CYP1A1 3 0.19 0.18 0.51 62.96
15 INT162502 NEUROD1 Regulation of CYP1A1 2 0.07 0.09 0.25 62.96
16 INT162506 Gtf3a Regulation of CYP1A1 1 0.00 0.09 0.09 62.96
17 INT162503 AHR Regulation of CYP1A2 3 0.61 0.18 0.5 62.32
18 INT162501 NEUROD1 Regulation of CYP1A2 2 0.22 0.09 0.25 62.32
19 INT162507 Gtf3a Regulation of CYP1A2 1 0.00 0.09 0.09 62.32
20 INT278688 MTX1 Negative_regulation of Positive_regulation of SOAT1 1 0.04 0.69 0.54 60.84
21 INT162499 Binding of AHR and NEUROD1 3 0.25 0.19 0.49 60.48
22 INT203101 Binding of Aes and Mtx1 2 0.25 0.24 0.88 58.68
23 INT278695 MTX1 Negative_regulation of Phosphorylation of AKT1 1 0.04 0.81 0.62 58.24
24 INT353020 Binding of CD80 and Positive_regulation of Gene_expression of CD28 1 0.13 0.35 0.34 57.56
25 INT194647 Binding of CD28 and CD80 15 0.40 4.9 3.22 56.96
26 INT100018 TNF Positive_regulation of MAPK1 3 0.24 1.56 0.94 49.04
27 INT278694 TNF Positive_regulation of MAPK14 1 0.03 0.79 0.56 49.04
28 INT278689 TNF Positive_regulation of MAPK8 1 0.04 0.79 0.56 49.04
29 INT194646 Binding of CD28 and CD86 7 0.40 2.69 2.21 47.80
30 INT224700 TNF Positive_regulation of Angpt1 1 0.00 0.63 0.34 37.16
31 INT187064 ARSD Negative_regulation of CYP19A1 1 0.22 0.7 0.35 30.48
32 INT224697 TNF Positive_regulation of Akt1 1 0.01 0 0.15 29.28
33 INT224694 Il1 Positive_regulation of Akt1 1 0.01 0 0.15 28.64
34 INT334009 Binding of CCL25 and CCR9 1 0.40 0.96 0.4 28.16
35 INT334025 Binding of CCR9 and Ccl25 1 0.40 0.96 0.4 27.76
36 INT181998 TNFRSF11B Negative_regulation of Gene_expression of CTSK 1 0.07 1.98 0.27 11.44
37 INT181997 TNFRSF11B Negative_regulation of CTSK 1 0.05 0.58 0.14 6.60
38 INT149117 Binding of CD80 and CTLA4 31 0.52 12.7 7.73 5.00
39 INT155484 Binding of CD86 and CTLA4 15 0.52 8.85 6.09 5.00
40 INT64718 IL1B Positive_regulation of Gene_expression of IL6 15 0.59 9.37 4.48 5.00
41 INT101942 Binding of CD40 and CD40LG 16 0.23 15.24 4.01 5.00
42 INT186126 Binding of CD28 and CTLA4 9 0.52 4.13 3.12 5.00
43 INT171974 Binding of Tnfrsf11a and Tnfsf11 14 0.35 13.11 3.11 5.00
44 INT175329 Binding of ICAM1 and ITGAL 14 0.18 10.06 2.81 5.00
45 INT186128 Binding of CD2 and CD58 8 0.10 7.59 2.76 5.00
46 INT115367 Binding of IL6 and IL6R 12 0.07 8.16 2.36 5.00
47 INT184262 Binding of AGER and HMGB1 1 0.34 4.49 2.17 5.00
48 INT218309 Binding of CRP and IL6 3 0.23 4.78 1.36 5.00
49 INT121705 IL1B Positive_regulation of Gene_expression of MMP3 3 0.49 1.2 1.3 5.00
50 INT121703 IL1B Positive_regulation of Gene_expression of MMP1 3 0.49 1.14 1.27 5.00
51 INT186125 Negative_regulation of Binding of CD2 and CD58 3 0.12 3.04 1.06 5.00
52 INT206074 Binding of IL6 and IL6ST 7 0.32 3.79 1.01 5.00
53 INT187111 TIMP2 Regulation of MMP9 1 0.23 1.47 0.97 5.00
54 INT302828 Mapkapk5 Positive_regulation of Mapk1 1 0.07 1.38 0.91 5.00
55 INT224583 CSF2 Positive_regulation of IL1RN 1 0.02 1.3 0.88 5.00
56 INT224585 IL1B Positive_regulation of IL1RN 1 0.02 1.3 0.87 5.00
57 INT302831 Binding of Creb1 and Mapkapk5 1 0.07 1.3 0.79 5.00
58 INT205120 Binding of CD4 and CD8A 3 0.15 2.83 0.72 5.00
59 INT172134 Binding of IL6 and IL15 2 0.01 1.18 0.72 5.00
60 INT172147 Binding of IL15 and TNF 2 0.05 1.19 0.72 5.00
61 INT172097 Binding of HLA-E and Trav6-3 10 0.02 3.71 0.71 5.00
62 INT224580 Gene_expression of IL18 Positive_regulation of SERPINH1 1 0.00 1.34 0.7 5.00
63 INT187115 Binding of TIMP1 and TNF 2 0.30 1.07 0.7 5.00
64 INT172143 IL4 Positive_regulation of Protein_catabolism of TNF 2 0.11 1.7 0.69 5.00
65 INT186123 Binding of GIF and IL10 1 0.23 1.17 0.69 5.00
66 INT224678 Binding of Mmp14 and Mmp23 1 0.00 0.85 0.69 5.00
67 INT172146 IL10 Positive_regulation of Protein_catabolism of TNF 2 0.15 1.69 0.69 5.00
68 INT172142 IL10 Positive_regulation of Protein_catabolism of IL1B 2 0.03 1.69 0.68 5.00
69 INT172132 IL4 Positive_regulation of Protein_catabolism of IL1B 2 0.02 1.69 0.68 5.00
70 INT203758 Binding of IL6 and TNF 3 0.26 2.03 0.67 5.00
71 INT224683 Mmp14 Positive_regulation of Binding of Mmp9 1 0.01 0.81 0.65 5.00
72 INT224702 Timp2 Positive_regulation of Binding of Mmp14 and Mmp9 1 0.00 0.81 0.65 5.00
73 INT224693 Timp2 Positive_regulation of Binding of Mmp9 1 0.01 0.81 0.65 5.00
74 INT224684 Binding of Mmp14 and Mmp9 1 0.01 0.81 0.64 5.00
75 INT171976 Il18 Positive_regulation of Gene_expression of IFNA1 1 0.01 1.37 0.64 5.00
76 INT299793 Positive_regulation of Binding of CD86 and CTLA4 1 0.17 1.64 0.63 5.00
77 INT299792 Positive_regulation of Binding of CD80 and CTLA4 1 0.17 1.63 0.63 5.00
78 INT302833 Gene_expression of Mir155 Negative_regulation of Gene_expression of Mmp3 1 0.03 1 0.57 5.00
79 INT334013 Ccl25 Positive_regulation of Gene_expression of Lrp1 1 0.07 0.98 0.56 5.00
80 INT302832 Tnfsf10 Positive_regulation of Akt1 1 0.04 1.63 0.56 5.00
81 INT302834 Cd4 Positive_regulation of Gene_expression of Il7 1 0.05 1.02 0.54 5.00
82 INT187114 TIMP2 Negative_regulation of ABCA1 1 0.02 0.28 0.51 5.00
83 INT187108 TIMP1 Negative_regulation of ABCA1 1 0.02 0.28 0.51 5.00
84 INT187116 TIMP2 Negative_regulation of MMP9 1 0.36 1.37 0.5 5.00
85 INT172081 TNF Regulation of IFNA1 1 0.03 1.13 0.5 5.00
86 INT172082 TNF Regulation of SFTPA1 1 0.05 0.85 0.5 5.00
87 INT299785 CTLA4 Negative_regulation of Binding of CD28 2 0.17 1.8 0.5 5.00
88 INT302838 TNF Positive_regulation of Sox18 1 0.00 0.71 0.5 5.00
89 INT302845 Il7 Positive_regulation of Gene_expression of TNF 1 0.01 0.98 0.49 5.00
90 INT302820 Stat3 Regulation of Positive_regulation of Il7 1 0.04 1.03 0.49 5.00
91 INT321598 Binding of MLL and TNF 1 0.05 1.07 0.49 5.00
92 INT302823 Stat3 Regulation of Gene_expression of Il7 1 0.04 1.03 0.49 5.00
93 INT224675 S100a4 Positive_regulation of Mmp3 1 0.04 0.94 0.48 5.00
94 INT260858 IL6 Positive_regulation of Gene_expression of VEGFA 2 0.31 1.77 0.48 5.00
95 INT158400 Binding of CD80 and CD86 3 0.36 0.76 0.48 5.00
96 INT302839 MIR15A Negative_regulation of Bcl2 1 0.15 1.41 0.47 5.00
97 INT184291 Binding of AGER and Crp 1 0.01 1.23 0.46 5.00
98 INT224698 Il17a Positive_regulation of Gene_expression of VEGFA 1 0.01 0.49 0.46 5.00
99 INT224699 Il18 Positive_regulation of Gene_expression of VEGFA 1 0.01 0.49 0.46 5.00
100 INT224674 S100a4 Positive_regulation of Gene_expression of Mmp9 1 0.03 0.85 0.45 5.00
101 INT224686 S100a4 Positive_regulation of Gene_expression of Mmp13 1 0.05 0.85 0.45 5.00
102 INT224692 S100a4 Positive_regulation of Gene_expression of Mmp1a 1 0.02 0.85 0.45 5.00
103 INT302829 Mapkapk5 Positive_regulation of Trp53 1 0.07 0.81 0.43 5.00
104 INT346130 Il17a Positive_regulation of Gene_expression of TNFSF11 1 0.08 0.61 0.41 5.00
105 INT299789 IL4 Negative_regulation of Gene_expression of RAE1 1 0.00 0.84 0.41 5.00
106 INT184292 Binding of AGER and chromosomal protein 1 1 0.01 0.87 0.41 5.00
107 INT302824 Mapkapk5 Positive_regulation of Phosphorylation of Hspb2 1 0.11 0.64 0.4 5.00
108 INT299786 IL4 Negative_regulation of Gene_expression of CD5 1 0.07 0.82 0.4 5.00
109 INT302825 Binding of Creb1 and Xpnpep1 1 0.00 0.64 0.39 5.00
110 INT333969 Binding of TNF and Cd4 1 0.03 1.28 0.39 5.00
111 INT302836 Negative_regulation of Mapk8 Negative_regulation of TNF Positive_regulation of Mir155 1 0.00 0.48 0.39 5.00
112 INT302815 TNF Positive_regulation of TNF Positive_regulation of Mir155 1 0.00 0.47 0.38 5.00
113 INT302840 Positive_regulation of TNF Positive_regulation of Mir155 1 0.01 0.47 0.38 5.00
114 INT181862 Binding of MPO and PRTN3 2 0.16 1.18 0.38 5.00
115 INT302821 Mdk Negative_regulation of Il1 1 0.02 0.91 0.38 5.00
116 INT302843 TNF Positive_regulation of Mir155 1 0.01 0.47 0.38 5.00
117 INT299790 IL4 Negative_regulation of Gene_expression of NPEPPS 1 0.00 0.86 0.37 5.00
118 INT224582 Binding of IL1B and Positive_regulation of Gene_expression of TNF 1 0.05 1.33 0.37 5.00
119 INT299788 INCENP Negative_regulation of Gene_expression of NPEPPS 1 0.00 0.86 0.37 5.00
120 INT224584 Binding of IL1RN and SIGMAR1 1 0.00 0.73 0.36 5.00
121 INT254391 Binding of F13A1 and GSN 1 0.00 1.08 0.34 5.00
122 INT254393 Binding of FN1 and GSN 1 0.01 1.08 0.34 5.00
123 INT224701 Timp3 Negative_regulation of TNF 1 0.01 0.65 0.34 5.00
124 INT188391 Binding of CD4 and HLA-DRB1 1 0.05 0.96 0.34 5.00
125 INT224691 Positive_regulation of Tlr4 Positive_regulation of Gene_expression of Il15 1 0.01 0.66 0.33 5.00
126 INT302830 Mapk14 Regulation of Mapkapk5 1 0.12 0.53 0.33 5.00
127 INT318299 Binding of F2 and PRTN3 1 0.01 1.92 0.33 5.00
128 INT224681 Tlr2 Positive_regulation of Gene_expression of Il15 1 0.01 0.66 0.33 5.00
129 INT302841 Mdk Positive_regulation of Positive_regulation of TNF 1 0.01 0.35 0.33 5.00
130 INT302842 Binding of S1PR1 and S1pr1 1 0.24 0.92 0.32 5.00
131 INT299791 Negative_regulation of Binding of CD28 and CTLA4 1 0.18 0.77 0.32 5.00
132 INT186127 CTLA4 Negative_regulation of CD28 1 0.19 0.74 0.32 5.00
133 INT224687 Il1 Positive_regulation of Bmp2 1 0.00 0.3 0.31 5.00
134 INT278693 ERAL1 Positive_regulation of CD4 1 0.05 1.1 0.31 5.00
135 INT334024 Ccl25 Positive_regulation of Gene_expression of CD36 1 0.31 0.36 0.31 5.00
136 INT278692 ERAL1 Positive_regulation of Positive_regulation of CD4 1 0.05 1.1 0.31 5.00
137 INT187102 Negative_regulation of Binding of MMP9 and TIMP2 1 0.36 0.69 0.3 5.00
138 INT254287 Binding of TNFSF13B and TNFRSF13B 1 0.01 1.33 0.3 5.00
139 INT187106 Binding of MMP9 and TIMP2 1 0.30 0.69 0.3 5.00
140 INT254288 Binding of ZNF623 and TNFSF13B 1 0.00 1.33 0.3 5.00
141 INT187113 Binding of IGHG3 and MMP9 1 0.01 0.63 0.3 5.00
142 INT187110 Binding of TIMP2 and GOPC 1 0.07 0.64 0.29 5.00
143 INT187105 TIMP2 Negative_regulation of Positive_regulation of MMP9 1 0.36 0.36 0.29 5.00
144 INT252033 Binding of HLA-DQA2 and KLRD1 1 0.00 0.54 0.29 5.00
145 INT334023 pma Positive_regulation of Gene_expression of CD36 1 0.04 0.31 0.28 5.00
146 INT187107 Binding of IGHG3 and TIMP2 1 0.01 0.62 0.28 5.00
147 INT302837 Binding of TNFRSF10D and Trp53 1 0.01 0.98 0.28 5.00
148 INT220870 Timp3 Negative_regulation of Adamts4 1 0.03 0.15 0.27 5.00
149 INT220871 Timp3 Negative_regulation of Adamts1 1 0.01 0.15 0.27 5.00
150 INT182325 TP53 Negative_regulation of Transcription of Birc5 1 0.01 1.34 0.26 5.00
151 INT302818 Gcat Negative_regulation of Syk 1 0.00 0.53 0.24 5.00
152 INT258398 Binding of IL6R and JAK1 1 0.01 0.75 0.23 5.00
153 INT352163 SNRPA Positive_regulation of Localization of IL10 1 0.06 0.87 0.23 5.00
154 INT302819 Regulation of S1pr1 Positive_regulation of Ptger2 1 0.02 0.35 0.22 5.00
155 INT172083 TNF Regulation of Regulation of IFNA1 1 0.03 0.91 0.22 5.00
156 INT187117 Negative_regulation of TIMP2 Negative_regulation of MMP9 1 0.36 0.6 0.22 5.00
157 INT318303 Negative_regulation of Myoz1 Negative_regulation of Transcription of IL2 1 0.00 0.75 0.21 5.00
158 INT302822 Tnfsf10 Positive_regulation of Protein_catabolism of Psmd9 1 0.03 0.78 0.21 5.00
159 INT299787 Binding of IL2 and ISG20 1 0.04 0.82 0.21 5.00
160 INT171973 Tnfsf11 Positive_regulation of Gene_expression of Il1 1 0.06 0.21 0.21 5.00
161 INT171972 Tnfsf11 Positive_regulation of Gene_expression of Il6 1 0.08 0.21 0.21 5.00
162 INT302835 S1pr1 Positive_regulation of Ptger2 1 0.03 0.3 0.2 5.00
163 INT224688 Pten Regulation of Akt1 1 0.04 1.12 0.19 5.00
164 INT318298 MECOM Negative_regulation of Binding of CD28 1 0.00 1.08 0.18 5.00
165 INT345924 IL6 Regulation of Gene_expression of SPHAR 1 0.00 0.21 0.18 5.00
166 INT302846 Negative_regulation of Binding of S1PR1 and S1pr1 1 0.28 0.41 0.18 5.00
167 INT224680 Tgfb1 Negative_regulation of Pten 1 0.00 1.19 0.18 5.00
168 INT258399 Binding of IL6R and IL6ST 1 0.06 0.61 0.18 5.00
169 INT181996 TNFRSF11B Positive_regulation of Gene_expression of TIMP1 1 0.00 0.67 0.18 5.00
170 INT295439 Binding of AES and IFNA1 1 0.25 0.46 0.17 5.00
171 INT182326 LBR Positive_regulation of Gene_expression of Birc5 1 0.00 0.46 0.17 5.00
172 INT254392 Binding of CRP and GSN 1 0.12 0.33 0.16 5.00
173 INT293361 Binding of CD80 and KLRD1 1 0.00 0.38 0.16 5.00
174 INT293359 Binding of CD86 and KLRD1 1 0.00 0.38 0.16 5.00
175 INT302844 Positive_regulation of Binding of S1PR1 and S1pr1 1 0.32 0.52 0.15 5.00
176 INT302826 Negative_regulation of Binding of Il2 and Kit 1 0.01 1.28 0.14 5.00
177 INT302827 Binding of Il2 and Kit 1 0.01 1.27 0.14 5.00
178 INT224677 L1cam Positive_regulation of Positive_regulation of Mapk14 1 0.00 0.39 0.13 5.00
179 INT224685 L1cam Positive_regulation of Positive_regulation of Akt1 1 0.01 0.34 0.13 5.00
180 INT293312 CTLA4 Negative_regulation of Binding of CD28 and CD80 1 0.01 0.29 0.12 5.00
181 INT187112 Binding of TIMP2 and Positive_regulation of TIMP1 1 0.32 0.26 0.1 5.00
182 INT254286 Binding of TNFSF13B and TNFRSF13C 1 0.07 1.26 0.08 5.00
183 INT187104 Binding of IGHG3 and TIMP1 1 0.01 0.22 0.07 5.00
184 INT345925 IL6 Negative_regulation of Gene_expression of CYP1A2 1 0.13 0.18 0.06 5.00
185 INT334027 Ccl25 Regulation of Gene_expression of CD36 1 0.14 0.24 0.05 5.00
186 INT224679 Il18 Positive_regulation of Gene_expression of Vcam1 1 0.01 0.41 0.05 5.00
187 INT224696 TNF Positive_regulation of Gene_expression of Mcl1 1 0.01 1.07 0.05 5.00
188 INT334026 pma Regulation of Gene_expression of CD36 1 0.02 0.16 0.05 5.00
189 INT293360 Binding of CSH1 and FKBP1A 1 0.00 0.14 0.05 5.00
190 INT293353 Binding of CD8A and Cd3e 1 0.01 0.07 0.04 5.00
191 INT224682 Mcl1 Regulation of Bak1 1 0.01 1.09 0.03 5.00
192 INT293367 Binding of CABIN1 and Ppia 1 0.00 0.19 0.03 5.00
193 INT293358 Binding of FKBP1A and CABIN1 1 0.00 0.07 0.03 5.00
194 INT224689 Binding of Bak1 and Mcl1 1 0.01 1.09 0.03 5.00
195 INT224676 Binding of Bax and Mcl1 1 0.01 1.09 0.03 5.00
196 INT287814 Apex1 Positive_regulation of Gene_expression of Rnf128 1 0.03 0.15 0.03 5.00
197 INT293368 Binding of CSH1 and Ppia 1 0.00 0.19 0.03 5.00
198 INT224690 Mcl1 Regulation of Bax 1 0.00 1.09 0.03 5.00
199 INT293355 Binding of Fkbp1a and CABIN1 1 0.00 0.12 0 5.00
200 INT293357 RORC Regulation of PPP2R4 1 0.00 0 0 5.00

Single Events

The table below shows the top 200 pain related interactions that have been reported for Leflunomide. They are ordered first by their pain relevance and then by number of times they were reported in Leflunomide. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT13556 Gene_expression of CD4 367 0.78 230.82 41.74 100.00
2 INT278715 Gene_expression of LEF1 10 0.33 5.43 1.54 100.00
3 INT278727 Negative_regulation of Gene_expression of LEF1 3 0.11 1.59 1.47 100.00
4 INT152951 Negative_regulation of LEF1 5 0.41 3.22 1.31 100.00
5 INT6482 Positive_regulation of Gene_expression of TNF 659 0.70 569.88 210 100.00
6 INT278710 Phosphorylation of LEF1 1 0.05 0.76 0.82 100.00
7 INT13354 Transcription of TNF 108 0.72 85.81 42.32 100.00
8 INT163080 Gene_expression of STAT6 5 0.59 3.18 2.94 99.98
9 INT110755 Negative_regulation of Positive_regulation of Mapk8 15 0.46 9.91 2.98 99.98
10 INT108921 Negative_regulation of Positive_regulation of Mapk9 3 0.25 1.8 1.99 99.98
11 INT142679 Negative_regulation of Phosphorylation of Mapk9 1 0.17 0.51 1.37 99.98
12 INT110304 Negative_regulation of Gene_expression of NOSTRIN 6 0.55 2.22 2.27 99.98
13 INT30169 Negative_regulation of Pde4a 107 0.58 81 36.23 99.96
14 INT5235 Negative_regulation of TNF 924 0.59 772.91 331.98 99.92
15 INT50058 Negative_regulation of Cpox 907 0.58 426.28 428.29 99.92
16 INT6483 Gene_expression of TNF 3152 0.78 2515.62 929.82 99.90
17 INT318301 Negative_regulation of DHODH 1 0.03 0.6 0.44 99.84
18 INT163082 Negative_regulation of STAT6 2 0.42 2.35 2.28 99.78
19 INT109928 Negative_regulation of Positive_regulation of MAPK8 19 0.42 10.42 5.23 99.74
20 INT110181 Negative_regulation of Phosphorylation of MAPK8 20 0.57 9.43 4.06 99.74
21 INT2391 Negative_regulation of PTGS1 501 0.59 207.62 205.6 99.72
22 INT170528 Negative_regulation of Gene_expression of CD4 25 0.41 17.98 3.6 99.72
23 INT2431 Positive_regulation of Mpo 275 0.70 211.99 78.47 99.66
24 INT127039 Negative_regulation of Ppig 13 0.21 5.29 3.87 99.66
25 INT91703 Negative_regulation of Myoz1 78 0.58 53.78 13.5 99.62
26 INT96913 Positive_regulation of Mapk8 179 0.69 130.44 32.2 99.52
27 INT96912 Positive_regulation of Phosphorylation of Mapk8 29 0.69 18.33 8.14 99.52
28 INT108919 Positive_regulation of Mapk9 9 0.34 3.55 4.74 99.52
29 INT142678 Positive_regulation of Phosphorylation of Mapk9 4 0.51 2.1 1.6 99.52
30 INT113775 Negative_regulation of Gene_expression of CCR5 6 0.43 3.97 2.28 99.44
31 INT111594 Positive_regulation of Gene_expression of NOSTRIN 20 0.32 8.69 5 99.42
32 INT96915 Phosphorylation of Mapk8 73 0.81 40.69 11.44 99.28
33 INT142676 Phosphorylation of Mapk9 5 0.61 1.48 1.48 99.28
34 INT62895 Gene_expression of NOSTRIN 51 0.75 28.8 10.68 99.22
35 INT116950 Negative_regulation of MAPK8 103 0.57 44.48 17.53 99.20
36 INT68653 Negative_regulation of JUN 34 0.58 14.27 6.56 99.20
37 INT77281 Negative_regulation of HIVEP1 132 0.49 102.78 5.36 99.16
38 INT60691 Gene_expression of Il12a 331 0.78 208.03 75.96 99.14
39 INT132161 Gene_expression of MTX1 48 0.58 26.55 32.32 99.14
40 INT88322 Gene_expression of CCR5 111 0.78 77.36 39.84 98.96
41 INT88318 Gene_expression of CXCR4 208 0.77 189.67 31.72 98.96
42 INT80690 Positive_regulation of MAPK8 223 0.68 125.63 36.75 98.96
43 INT106745 Localization of CRP 65 0.81 66.44 15.21 98.96
44 INT73959 Positive_regulation of NOSTRIN 49 0.61 31.1 11.27 98.94
45 INT19856 Gene_expression of CD8A 240 0.75 147.86 26.39 98.88
46 INT81796 Binding of AGRP 62 0.36 37.19 5.3 98.82
47 INT109929 Phosphorylation of MAPK8 102 0.81 39.98 16.54 98.72
48 INT85843 Negative_regulation of BPI 5 0.35 5.13 3.77 98.64
49 INT58301 Positive_regulation of Mpo 87 0.70 80.19 23.99 98.64
50 INT274041 Binding of Pml 1 0.12 0.77 0.27 98.48
51 INT124606 Positive_regulation of Gene_expression of Mpo 14 0.49 12.66 3.24 98.40
52 INT163084 Negative_regulation of Gene_expression of STAT6 2 0.42 0.58 0.74 98.36
53 INT275449 Regulation of MFI2 8 0.44 6.49 1.7 98.32
54 INT116281 Negative_regulation of Gene_expression of Mmp13 15 0.41 9.96 3.41 98.32
55 INT138606 Negative_regulation of Positive_regulation of F2 2 0.12 0.54 0.74 98.30
56 INT238653 Regulation of MTX1 2 0.30 1.71 1.42 98.30
57 INT79270 Gene_expression of MKI67 113 0.77 63.52 3.38 98.24
58 INT112017 Regulation of Hand2 77 0.36 62.23 18.04 98.16
59 INT2129 Positive_regulation of F2 83 0.70 58.95 12.63 98.08
60 INT138605 Negative_regulation of Phosphorylation of BCL2L10 3 0.26 2.28 2.13 98.06
61 INT142677 Negative_regulation of Positive_regulation of Bcl2 4 0.36 3.09 2.24 97.96
62 INT95423 Negative_regulation of Bcl2l1 26 0.41 21.66 3.81 97.96
63 INT80222 Negative_regulation of Bcl2 82 0.58 69.16 13.18 97.96
64 INT274040 Localization of Pml 1 0.24 0.77 0.27 97.96
65 INT140193 Gene_expression of Mmp3 58 0.71 49.65 25.4 97.96
66 INT170313 Gene_expression of Mmp1a 50 0.65 38.53 21.36 97.96
67 INT116282 Gene_expression of Mmp13 83 0.75 45.4 20.18 97.96
68 INT61519 Gene_expression of Mpo 112 0.78 89.29 18.22 97.92
69 INT19218 Negative_regulation of Positive_regulation of CD4 9 0.41 9.21 0.69 97.86
70 INT18883 Negative_regulation of RYBP 53 0.56 21.14 57.52 97.84
71 INT138607 Phosphorylation of BCL2L10 3 0.36 2.27 2.1 97.84
72 INT39699 Negative_regulation of Positive_regulation of RYBP 11 0.41 3.73 10.42 97.84
73 INT102272 Regulation of TH1L 41 0.44 30.89 11.63 97.84
74 INT23177 Negative_regulation of Gene_expression of HLA-DRA 50 0.44 16.99 10.55 97.82
75 INT97825 Negative_regulation of Dhodh 2 0.57 1.21 0.64 97.80
76 INT3796 Gene_expression of Ighm 130 0.77 69.61 13.78 97.80
77 INT17275 Gene_expression of HIVEP1 267 0.75 232.07 24.06 97.76
78 INT52264 Gene_expression of IK 180 0.77 90.87 51.87 97.64
79 INT16364 Gene_expression of HLA-DRA 234 0.78 118.81 45.01 97.62
80 INT76313 Gene_expression of CD38 30 0.64 20.74 5.27 97.62
81 INT5328 Positive_regulation of CD4 191 0.69 133.43 21.31 97.60
82 INT187077 Positive_regulation of Localization of ESRRB 1 0.03 0.74 0.63 97.60
83 INT93747 Localization of Cat 9 0.56 4.25 0.88 97.56
84 INT22967 Positive_regulation of RYBP 94 0.56 37.04 85.92 97.56
85 INT80220 Positive_regulation of Bcl2 71 0.58 57.73 7.86 97.52
86 INT17276 Negative_regulation of Gene_expression of HIVEP1 27 0.42 26.85 2.61 97.44
87 INT86245 Positive_regulation of Bcl2l1 15 0.46 12.67 3.11 97.32
88 INT187071 Localization of ESRRB 2 0.04 0.9 0.67 97.16
89 INT18311 Positive_regulation of CD8A 145 0.69 113.48 19.44 97.14
90 INT25610 Positive_regulation of Gene_expression of Il1 136 0.67 104.43 43.86 97.04
91 INT232510 Negative_regulation of Gene_expression of CXCR4 18 0.58 20.27 2.54 97.00
92 INT325293 Negative_regulation of Gene_expression of CD38 1 0.14 0.55 0.22 96.92
93 INT19472 Gene_expression of Il1 554 0.76 419.75 175.35 96.84
94 INT75540 Positive_regulation of TH1L 62 0.67 43.45 15.02 96.78
95 INT191825 Regulation of Positive_regulation of CD8A 3 0.12 2.5 0.62 96.74
96 INT71047 Gene_expression of CYP19A1 122 0.78 68.78 22.21 96.68
97 INT133809 Negative_regulation of Gene_expression of CYP19A1 9 0.43 7.67 2.99 96.68
98 INT137400 Regulation of Mtx1 16 0.52 9.19 9.45 96.64
99 INT89401 Negative_regulation of Phosphorylation of AKT1 68 0.58 35.61 2.8 96.64
100 INT278711 Negative_regulation of Phosphorylation of HIST2H3C 1 0.05 0 0.18 96.64
101 INT20331 Positive_regulation of CYP1A2 31 0.69 8.6 5.92 96.40
102 INT20332 Positive_regulation of Positive_regulation of CYP1A2 4 0.69 0.68 2.17 96.40
103 INT211133 Negative_regulation of MTX1 8 0.19 3.86 4.87 96.32
104 INT3545 Positive_regulation of Mtx1 27 0.42 11.97 14.83 96.20
105 INT89396 Phosphorylation of AKT1 225 0.82 111.66 19.61 96.04
106 INT182320 Binding of MTX1 14 0.18 8.5 7.65 95.92
107 INT200734 Phosphorylation of HIST2H3C 6 0.25 3.2 0.78 95.92
108 INT81777 Negative_regulation of Gene_expression of IK 22 0.08 11.55 8.09 95.68
109 INT5332 Negative_regulation of Gene_expression of NPEPPS 11 0.04 7.79 4.29 95.68
110 INT9220 Gene_expression of Ighg1 125 0.77 85.74 15.92 95.60
111 INT11340 Positive_regulation of SLC17A5 120 0.67 113.52 14.5 95.52
112 INT9852 Positive_regulation of Gpt 563 0.70 364.64 146.82 95.52
113 INT91371 Negative_regulation of STAT3 34 0.59 25 4.08 95.20
114 INT93948 Negative_regulation of Gene_expression of Il12a 48 0.55 27.77 16.87 95.20
115 INT9658 Negative_regulation of Gene_expression of Il6 110 0.59 66.29 32.58 95.12
116 INT9659 Gene_expression of Il6 991 0.78 715.11 265.57 95.12
117 INT5333 Gene_expression of NPEPPS 45 0.65 26.34 15.25 95.08
118 INT86998 Regulation of HIVEP1 49 0.44 37.83 4 95.06
119 INT189392 Gene_expression of MFI2 6 0.57 7.69 1.45 94.64
120 INT119839 Gene_expression of STAT1 17 0.75 8.36 2.7 94.64
121 INT211132 Positive_regulation of Gene_expression of MTX1 4 0.23 2.71 2.94 94.64
122 INT119837 Positive_regulation of Gene_expression of STAT1 6 0.49 3.66 1.73 94.64
123 INT189395 Positive_regulation of Gene_expression of MFI2 2 0.15 1.4 0.24 94.64
124 INT34869 Negative_regulation of PTGS2 778 0.59 366.76 319.85 94.44
125 INT95787 Positive_regulation of Mapk1 568 0.70 226.51 220.94 94.04
126 INT69322 Negative_regulation of MAPK14 70 0.54 42.92 22.71 93.96
127 INT278712 Negative_regulation of STAT4 1 0.21 1.22 1.29 93.76
128 INT278717 Gene_expression of STAT4 1 0.39 1.17 1.26 93.76
129 INT16404 Regulation of CD4 54 0.61 33.05 10.29 93.76
130 INT278725 Negative_regulation of Gene_expression of STAT4 1 0.21 0.6 0.74 93.76
131 INT170601 Positive_regulation of Gene_expression of GOPC 122 0.43 42.79 11.68 93.72
132 INT157666 Positive_regulation of GOPC 335 0.60 120.19 42.75 93.72
133 INT111462 Negative_regulation of Phosphorylation of Mapk1 45 0.57 19.49 15.59 93.28
134 INT92434 Phosphorylation of Mapk1 287 0.82 91.65 83.46 93.28
135 INT90091 Gene_expression of GOPC 967 0.67 366.22 103.6 93.24
136 INT211200 Regulation of SERPINH1 2 0.03 3.8 1.75 93.08
137 INT103554 Positive_regulation of MTX1 19 0.45 11.23 10 92.64
138 INT287811 Gene_expression of Iltifb 1 0.03 0.99 0.56 92.64
139 INT10709 Negative_regulation of CD4 106 0.59 95.6 14.89 92.52
140 INT28249 Positive_regulation of HLA-DRA 25 0.70 13.63 3.25 92.48
141 INT2039 Regulation of CYP2B6 30 0.60 7.75 6.43 92.48
142 INT155010 Positive_regulation of Gene_expression of IL17A 23 0.64 20.17 7.15 92.36
143 INT70134 Negative_regulation of TXK 124 0.23 81.96 9.59 92.28
144 INT155012 Negative_regulation of Gene_expression of IL17A 11 0.36 8.64 1.94 92.08
145 INT79709 Regulation of M1 13 0.24 4.8 4.9 91.76
146 INT5116 Gene_expression of IL2 670 0.78 291.13 146.69 91.76
147 INT214579 Positive_regulation of CD38 4 0.24 1.22 0.3 91.60
148 INT145266 Gene_expression of IL17A 154 0.75 109.83 45.33 91.52
149 INT10194 Positive_regulation of IL6 702 0.70 600.62 183.38 90.84
150 INT153773 Regulation of Gene_expression of CTSK 2 0.34 1.36 0.62 90.64
151 INT182004 Regulation of Localization of CTSK 1 0.20 0.58 0.18 90.64
152 INT1126 Negative_regulation of CD79A 46 0.59 31.07 6 90.24
153 INT67796 Negative_regulation of CTLA4 13 0.39 8.36 2.39 90.16
154 INT89395 Negative_regulation of AKT1 127 0.58 70.27 12.54 90.12
155 INT278719 Negative_regulation of HIST2H3C 1 0.05 0 0.42 90.12
156 INT10016 Negative_regulation of CD8A 81 0.42 56.68 13.15 90.12
157 INT91527 Gene_expression of CTSK 38 0.78 22.21 7.42 90.04
158 INT21406 Negative_regulation of Gene_expression of IgG 20 0.41 9.36 3.58 89.56
159 INT125237 Negative_regulation of Gene_expression of CD40LG 16 0.54 9.9 3.27 89.56
160 INT133316 Localization of CTSK 5 0.52 2.43 0.43 89.48
161 INT6481 Binding of TNF 624 0.48 510.2 214.82 89.44
162 INT226443 Binding of STAT4 3 0.45 3.81 2.06 89.12
163 INT4509 Gene_expression of IgG 426 0.76 293.69 56.64 89.12
164 INT5059 Positive_regulation of TNF 1050 0.70 896.51 322.81 88.96
165 INT83246 Regulation of Positive_regulation of PPIG 1 0.44 1.61 0.72 88.88
166 INT60764 Positive_regulation of PPIG 39 0.67 17.08 13.48 88.88
167 INT25076 Negative_regulation of Gene_expression of Il1 41 0.52 30.58 13.85 88.88
168 INT4216 Gene_expression of CD40LG 328 0.78 256.02 44.23 88.80
169 INT39153 Positive_regulation of PTGS2 182 0.70 96.16 60.6 88.56
170 INT130731 Protein_catabolism of COL2A1 47 0.96 21.86 9.28 88.36
171 INT130729 Negative_regulation of Protein_catabolism of COL2A1 15 0.42 7.59 3.35 88.36
172 INT83119 Negative_regulation of Gene_expression of IL12A 24 0.42 17.52 5.69 88.28
173 INT192409 Positive_regulation of Gene_expression of IFN1@ 102 0.67 64.66 18.8 88.24
174 INT15516 Gene_expression of Crp 711 0.77 615.33 173.09 88.24
175 INT154229 Gene_expression of ARSD 22 0.57 12.5 6.19 87.84
176 INT61619 Gene_expression of IL12A 194 0.77 146.07 41.97 87.76
177 INT10274 Positive_regulation of Il1b 123 0.70 79.76 73.56 87.64
178 INT54826 Binding of LTB4R 7 0.29 1.51 1.59 87.56
179 INT105777 Gene_expression of Pde4a 30 0.76 12.67 8.52 87.28
180 INT219595 Positive_regulation of Gene_expression of Pde4a 3 0.39 2.81 1.11 87.28
181 INT11313 Positive_regulation of Il6 526 0.70 331.27 201.59 87.24
182 INT48891 Positive_regulation of Il10 143 0.70 101.42 56.72 87.00
183 INT170332 Gene_expression of IFN1@ 477 0.75 275.21 69.65 86.52
184 INT50957 Negative_regulation of Il6 134 0.59 79.08 42.67 86.24
185 INT83708 Negative_regulation of MAPK1 156 0.57 84.93 27.85 85.68
186 INT216291 Negative_regulation of BTK 4 0.42 4.9 0.67 85.68
187 INT11346 Binding of Mtx1 39 0.41 24.88 21.21 85.20
188 INT18009 Positive_regulation of CRP 518 0.70 553.03 103.74 85.12
189 INT6852 Localization of TNF 883 0.81 705.95 270.84 84.32
190 INT160562 Localization of Cd4 49 0.71 27.58 6.78 84.32
191 INT48901 Negative_regulation of IL6 186 0.57 136.33 57.87 84.08
192 INT187074 Negative_regulation of Gene_expression of LILRA3 3 0.14 1.09 0.84 83.84
193 INT174193 Gene_expression of LILRA3 20 0.28 12.65 5.1 83.52
194 INT108501 Binding of ARSD 14 0.32 11.5 2.93 83.40
195 INT187076 Negative_regulation of Binding of ARSD 1 0.21 1.11 0.61 83.40
196 INT93534 Gene_expression of Tnfsf11 185 0.77 119.26 33.66 83.00
197 INT38556 Gene_expression of DBT 47 0.50 12.52 5.6 82.96
198 INT17612 Gene_expression of CRP 676 0.78 580.61 119.03 82.72
199 INT117543 Regulation of Gene_expression of CD14 21 0.59 6.66 7.67 82.72
200 INT104221 Regulation of Gene_expression of CRP 30 0.45 20.01 4.07 82.72
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