P:Locus ceruleus

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Pain Term
Category Anatomy
Synonyms Locus Caeruleus, Locus Coeruleus, Locus Correleus
Pain Specific No
Documents 1497
Hot Single Events 200
Hot Interactions 60

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported for Locus ceruleus. They are ordered first by their pain relevance and then by number of times they were reported for Locus ceruleus. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT57246 Crh Positive_regulation of Positive_regulation of Caprin2 1 0.01 0.55 0.6 100.00
2 INT67966 Cck Positive_regulation of Adarb1 2 0.03 0 1.63 100.00
3 INT72319 Adarb1 Positive_regulation of Gene_expression of Fos 3 0.10 0.1 1.44 100.00
4 INT72318 Adarb1 Positive_regulation of Positive_regulation of Cck 1 0.04 0 0.72 100.00
5 INT186539 Crh Regulation of Hpse 1 0.09 0.52 0.1 100.00
6 INT253836 Cck Regulation of DST 1 0.03 0.42 0.95 100.00
7 INT8975 Gal Positive_regulation of Localization of Gnrhr 1 0.00 0.06 0.33 100.00
8 INT150681 Pomc Positive_regulation of Camk2a 1 0.47 0.07 0.8 99.84
9 INT11250 Cck Positive_regulation of Gene_expression of Fos 14 0.78 0.08 7.29 99.68
10 INT150682 Pomc Regulation of Gene_expression of Eif2ak3 1 0.37 0.17 1.44 99.68
11 INT151020 Binding of Pdyn and Crh 1 0.14 0.42 1.59 99.68
12 INT150679 Pomc Regulation of Gene_expression of Camk2a 1 0.30 0.07 0.79 99.68
13 INT40887 Penk Regulation of Th 1 0.04 0 1.53 99.52
14 INT63544 Adra2a Regulation of Nisch 1 0.18 0 0.79 99.48
15 INT29781 PDYN Negative_regulation of Npr1 1 0.00 0.22 0.84 99.48
16 INT11252 Cck Positive_regulation of Fos 6 0.78 0 3.79 99.44
17 INT11251 Negative_regulation of Cck Positive_regulation of Fos 2 0.48 0 1 99.44
18 INT43793 Positive_regulation of Porf1 Positive_regulation of Localization of LH 1 0.02 0.1 0.35 99.42
19 INT150680 Pomc Negative_regulation of Gene_expression of Eif2ak3 1 0.35 0.07 0.8 99.40
20 INT261374 Nsdhl Regulation of Esr2 1 0.05 0.76 0.41 99.26
21 INT261370 Nsdhl Regulation of Esr1 1 0.01 0.75 0.41 99.26
22 INT253826 Cck Regulation of Nts 1 0.21 0.36 0.94 99.00
23 INT69562 Positive_regulation of AP2M1 Positive_regulation of Regulation of Adrb3 1 0.01 0.19 1.24 98.96
24 INT214163 Binding of Lep and Nts 1 0.04 0.21 0.74 98.96
25 INT135119 Binding of Pomc and Crh 1 0.35 0 0.67 98.08
26 INT63859 Oprm1 Negative_regulation of Oprm1 1 0.10 0.08 0.86 97.68
27 INT63858 Oprm1 Negative_regulation of Penk 1 0.05 0.08 0.86 97.68
28 INT121838 Sct Positive_regulation of Localization of Fos 1 0.38 0 0.35 97.56
29 INT8980 Gal Regulation of PLCB1 1 0.18 0.13 0.68 97.52
30 INT31794 Hps6 Positive_regulation of Th 1 0.03 0 0.38 97.16
31 INT76248 Tac1 Positive_regulation of Gene_expression of Fos 1 0.34 0.34 0.56 96.60
32 INT180194 CRH Positive_regulation of CRHR2 1 0.02 0.24 0.27 95.84
33 INT180195 CRH Regulation of CRHR2 1 0.01 0.24 0.27 95.84
34 INT49150 GAL Regulation of Localization of Gnrhr 1 0.00 0.09 0.51 94.52
35 INT106069 TH Positive_regulation of Th 1 0.07 0.16 1.14 93.72
36 INT98726 Binding of Msr1 and Tacr2 1 0.00 0.06 0.42 92.36
37 INT64776 Binding of Oprm1 and Kcnj3 1 0.38 0 0.6 91.84
38 INT16531 Ghrh Positive_regulation of Localization of Gh1 31 0.64 2.12 14.2 91.68
39 INT92974 Creb1 Regulation of Positive_regulation of Galr1 1 0.32 0 0.57 91.68
40 INT121839 Sct Positive_regulation of Nts 1 0.35 0.06 0.43 90.48
41 INT98725 Msr1 Positive_regulation of Gene_expression of Creb1 1 0.00 0.09 0.6 89.92
42 INT121837 Sct Positive_regulation of Th 1 0.23 0.06 0.43 89.56
43 INT106062 Positive_regulation of Oprl1 Positive_regulation of Mapk1 1 0.13 0.16 1.35 88.44
44 INT106071 Positive_regulation of Oprl1 Positive_regulation of MAPK3 1 0.12 0.16 1.34 88.44
45 INT91107 Positive_regulation of Ptgs1 Positive_regulation of Localization of Crh 1 0.00 0.56 0.41 88.12
46 INT182659 Positive_regulation of Gins4 Positive_regulation of Rem1 1 0.00 0.1 0.15 88.00
47 INT186540 Binding of Cort and Hpse 1 0.05 0.92 0.08 87.04
48 INT151633 Binding of Npy and Tacr1 1 0.16 0.39 0.4 86.24
49 INT103724 Oprd1 Positive_regulation of Gtpbp4 3 0.30 0.91 4.18 85.88
50 INT103725 Negative_regulation of Oprd1 Positive_regulation of Gtpbp4 1 0.17 0.38 1.65 85.88
51 INT103726 Regulation of Oprd1 Positive_regulation of Gtpbp4 1 0.10 0.38 1.64 85.88
52 INT184874 Drd1a Regulation of Gene_expression of Drd2 1 0.13 0.97 0.51 85.28
53 INT63543 Binding of Adra2a and Serpini1 1 0.13 0 1 84.76
54 INT122688 Binding of Galr1 and Th 1 0.14 0.07 0.83 84.76
55 INT122687 Binding of Galr2 and Th 1 0.13 0.07 0.83 84.48
56 INT122686 Binding of Galr3 and Th 1 0.14 0.07 0.83 84.04
57 INT354367 Binding of FGFR1 and Tlr4 1 0.01 1.23 0.53 83.68
58 INT106070 Positive_regulation of Oprl1 Positive_regulation of TH 1 0.13 0.15 1.36 82.60
59 INT88614 Penk Negative_regulation of Il2 1 0.23 0 1.08 81.48
60 INT275800 Binding of Sh2d1a and Tacr1 1 0.01 0.29 0.07 80.88
61 INT134212 CRH Regulation of Localization of POMC 1 0.47 2.89 2.9 79.68
62 INT24336 Negative_regulation of Binding of PRB1 and RTCA 1 0.00 0.1 0.45 78.96
63 INT24334 Binding of PRB1 and RTCA 1 0.00 0.09 0.44 78.96
64 INT24335 Positive_regulation of Binding of PRB1 and RTCA 1 0.00 0.09 0.44 78.96
65 INT275802 Hcrt Regulation of Rem1 1 0.20 0.95 0.17 78.88
66 INT275801 Binding of Hcrt and Sh2d1a 1 0.03 0.29 0.06 78.24
67 INT58140 Binding of AP2M1 and Oprm1 1 0.01 0.4 1.23 75.36
68 INT153215 Htr5b Positive_regulation of Pag1 1 0.01 0.57 1.22 75.00
69 INT73087 Adarb1 Positive_regulation of Fos 1 0.02 0 0.76 75.00
70 INT275803 Hcrt Negative_regulation of Rem1 1 0.19 0.35 0.1 73.56
71 INT24388 CRH Positive_regulation of Localization of POMC 8 0.51 5.67 3.35 72.80
72 INT169769 Mir16-1 Regulation of Slc6a4 1 0.24 0 0.74 72.16
73 INT114676 Mdm2 Negative_regulation of p53-ps 1 0.10 0.26 0.48 71.68
74 INT121840 Sct Positive_regulation of Gene_expression of Fos 1 0.61 0 0.48 71.48
75 INT214170 Binding of DST and Lep 1 0.02 0.17 0.18 70.48
76 INT172207 Binding of Drd4 and ADHD1 2 0.03 1.56 0.48 70.32
77 INT253828 Creb1 Positive_regulation of Gene_expression of Cartpt 1 0.19 0.15 0.72 68.00
78 INT253829 Atf6b Positive_regulation of Gene_expression of Cartpt 1 0.24 0.15 0.72 68.00
79 INT253833 Positive_regulation of Atf6b Positive_regulation of Gene_expression of Cartpt 1 0.24 0.15 0.72 68.00
80 INT275799 Binding of Hcrt and Lynx1 1 0.01 0.34 0.07 67.88
81 INT169768 Binding of Slc6a4 and Mir16-1 1 0.33 0 1.25 66.48
82 INT105771 CRH Negative_regulation of Localization of GNRH1 1 0.35 0.56 0.39 66.48
83 INT261387 Nsdhl Negative_regulation of Casp3 1 0.03 1.08 0.19 66.08
84 INT113931 Mors1 Positive_regulation of Gtpbp4 1 0.02 0 0.67 66.00
85 INT321475 Slc6a2 Positive_regulation of Ubqln1 1 0.00 0.38 1.19 65.04
86 INT105772 SST Negative_regulation of Localization of GH1 1 0.10 0.54 0.38 63.16
87 INT105770 SST Negative_regulation of Localization of TRH 1 0.17 0.54 0.38 63.16
88 INT66535 Binding of Pnoc and Oprl1 43 0.54 5.93 32.4 59.60
89 INT321474 Binding of Slc6a2 and Ubqln1 1 0.00 0.8 2.27 59.24
90 INT321478 Binding of Slc6a2 and Flvcr2 1 0.00 0.41 1.14 59.24
91 INT321476 Binding of Slc6a3 and Slc6a2 1 0.01 0.41 1.14 59.24
92 INT321477 Binding of Ubqln1 and Flvcr2 1 0.00 0.81 2.26 58.04
93 INT321473 Binding of Slc6a3 and Ubqln1 1 0.00 0.41 1.13 58.04
94 INT29206 Crh Regulation of Localization of POMC 4 0.64 0.96 4.68 57.84
95 INT353978 Lmx1b Regulation of Gene_expression of Pet1 1 0.31 0.21 0.53 57.76
96 INT34856 Hpd Negative_regulation of Dbh 1 0.00 0 0.39 56.16
97 INT68514 Pnoc Positive_regulation of Oprl1 10 0.59 3.56 9.57 54.88
98 INT312746 Ephb1 Positive_regulation of Localization of Ltp 1 0.05 0.07 0.55 50.84
99 INT34855 Negative_regulation of Maoa Negative_regulation of Th 1 0.17 0 0.34 45.28
100 INT57555 Binding of Oprm1 and Oprl1 2 0.06 0.05 0.97 40.56
101 INT64259 Binding of Gtpbp4 and Ptprg 1 0.06 0 1.1 38.80
102 INT262558 Phax Positive_regulation of Trpv1 1 0.01 1.26 1.92 37.64
103 INT214168 Msx1 Positive_regulation of Gene_expression of DST 1 0.00 0.13 0.09 37.60
104 INT190144 Binding of ABAT and Gabrg1 1 0.01 0 0.47 37.04
105 INT336556 SLC6A3 Positive_regulation of Gene_expression of GOPC 1 0.08 1.87 1.76 34.80
106 INT336559 SLC6A3 Positive_regulation of GOPC 1 0.08 1 1.15 34.80
107 INT336557 SLC6A3 Positive_regulation of Binding of GOPC 1 0.08 0.5 0.58 34.80
108 INT153924 Msr1 Regulation of Adrb3 1 0.02 0.24 0.32 34.80
109 INT312750 Elane Positive_regulation of Positive_regulation of Ltp 1 0.01 0.38 0.34 33.76
110 INT353981 Gene_expression of Pet1 Positive_regulation of Lmx1b 1 0.53 0 0.23 30.88
111 INT275798 Pag1 Regulation of Rem1 1 0.11 0.41 0 27.40
112 INT253834 Cck Regulation of Lep 1 0.19 0.23 0.55 26.72
113 INT86350 Negative_regulation of Adarb1 Negative_regulation of Positive_regulation of Fos 1 0.04 0.8 0.92 26.68
114 INT86349 Negative_regulation of Tacr1 Negative_regulation of Positive_regulation of Fos 1 0.42 0.8 0.92 26.68
115 INT153923 Msr1 Positive_regulation of Gene_expression of Tdo2 1 0.00 0.89 1.28 25.00
116 INT81424 Binding of Crh and Olr1000 1 0.06 0.17 0.09 25.00
117 INT214156 Pomc Negative_regulation of Gene_expression of Npy 1 0.39 0.07 0.09 24.80
118 INT214166 DST Negative_regulation of Gene_expression of Npy 1 0.02 0.07 0.09 24.08
119 INT256025 Binding of Agt and Igkv4-55 1 0.01 0.05 0 23.96
120 INT256028 Binding of Agt and Lnpep 1 0.19 1.16 0.24 23.28
121 INT214165 Agrp Negative_regulation of Localization of Npy 1 0.23 0.06 0.1 21.96
122 INT214144 Cck Positive_regulation of Pomc 1 0.15 0.94 2.39 19.20
123 INT214159 Cck Positive_regulation of Nts 1 0.03 0.93 2.34 19.20
124 INT29048 Oprd1 Regulation of Etf1 1 0.00 0 0.71 16.36
125 INT172206 Binding of Slc6a3 and ADHD1 2 0.03 2.76 1.61 15.36
126 INT184877 Negative_regulation of Binding of Slc6a3 and ADHD1 1 0.01 0.69 0.45 14.28
127 INT321479 Ubqln1 Regulation of Cfp 1 0.00 0.37 0.67 11.80
128 INT290821 CRX Positive_regulation of Cort 1 0.14 0.51 0.41 9.60
129 INT274372 Phc1 Negative_regulation of Slc6a3 1 0.06 0.47 1.99 8.52
130 INT279165 Calca Regulation of Gene_expression of Fdft1 1 0.02 0.41 1.37 6.16
131 INT259233 Binding of Oprm1 and Flna 1 0.03 0.25 25.89 5.00
132 INT106559 Binding of Bdnf and Ntrk2 23 0.43 11.09 7.33 5.00
133 INT259228 Binding of Oprm1 and Glul 1 0.00 0.08 7.22 5.00
134 INT26824 Crh Positive_regulation of Localization of Penk 7 0.54 0.42 6.49 5.00
135 INT182124 Binding of IRF6 and TLR4 14 0.10 16.11 4.65 5.00
136 INT259209 Binding of Glul and Flna 1 0.03 0 4.2 5.00
137 INT259230 Negative_regulation of Binding of Oprm1 and Flna 1 0.02 0 4.15 5.00
138 INT85743 Pdyn Positive_regulation of Oprk1 3 0.32 2.12 3.52 5.00
139 INT114134 Penk Positive_regulation of Oprm1 2 0.24 1.48 2.68 5.00
140 INT259231 Binding of Oprm1 and Ppp1r9b 1 0.01 0 2.67 5.00
141 INT259198 Oprm1 Negative_regulation of Binding of Oprm1 and Flna 1 0.00 0 2.64 5.00
142 INT259214 Oprm1 Negative_regulation of Binding of Flna and Flna 1 0.01 0 2.64 5.00
143 INT351281 AP1M2 Regulation of NCOR2 1 0.00 0.85 1.9 5.00
144 INT93293 Ngf Regulation of Trpv1 2 0.28 0.71 1.9 5.00
145 INT199486 Oprm1 Regulation of Gene_expression of Oprd1 1 0.02 0.49 1.84 5.00
146 INT199287 TNF Positive_regulation of Transcription of Oprm1 2 0.02 1.86 1.8 5.00
147 INT199503 ENG Positive_regulation of Oprk1 1 0.01 0.87 1.69 5.00
148 INT199504 ENG Positive_regulation of Oprm1 1 0.01 0.87 1.68 5.00
149 INT199497 Pdyn Negative_regulation of Il1 1 0.00 0.14 1.67 5.00
150 INT199490 Penk Positive_regulation of Oprk1 1 0.03 0.87 1.64 5.00
151 INT199501 Pdyn Positive_regulation of Oprm1 1 0.01 0.86 1.63 5.00
152 INT111892 Ptger2 Regulation of Ptger1 1 0.08 2.09 1.55 5.00
153 INT252633 Binding of TNF and Tnfrsf1b 4 0.05 3.66 1.54 5.00
154 INT121226 Ngf Regulation of Gene_expression of Trpv1 2 0.62 0.7 1.44 5.00
155 INT172203 Binding of Comt and Maoa 1 0.31 0.98 1.43 5.00
156 INT261831 Mapk1 Negative_regulation of Hspg2 1 0.00 1.26 1.42 5.00
157 INT199494 Crh Positive_regulation of Localization of Pdyn 1 0.02 0.43 1.4 5.00
158 INT259232 Binding of Flna and Positive_regulation of Localization of Oprm1 1 0.03 0 1.39 5.00
159 INT262568 Prkaca Regulation of Trpv1 2 0.10 0.65 1.38 5.00
160 INT15846 Crh Positive_regulation of Localization of ENG 3 0.07 0.42 1.38 5.00
161 INT259211 Binding of Ppp1r9b and Flna 1 0.06 0 1.33 5.00
162 INT261841 Mastl Positive_regulation of Trpa1 1 0.00 0.82 1.3 5.00
163 INT259229 Positive_regulation of Binding of Oprm1 and Flna 1 0.02 0 1.23 5.00
164 INT210982 Binding of Cnr1 and Cfp 2 0.22 1.27 1.2 5.00
165 INT253827 Cck Regulation of Cartpt 1 0.41 0 1.16 5.00
166 INT199493 Ngf Regulation of Oprd1 1 0.05 1.05 1.15 5.00
167 INT308172 Rvm Positive_regulation of Phosphorylation of GRIN1 1 0.50 0.68 1.14 5.00
168 INT308173 Binding of DRG1 and Tnfrsf1b 1 0.01 1.64 1.1 5.00
169 INT182125 Binding of CD14 and TLR4 7 0.25 3.78 1.03 5.00
170 INT263232 Prkcg Positive_regulation of Trpv4 1 0.12 1.1 1.02 5.00
171 INT263227 Positive_regulation of Prkcg Regulation of Trpv4 1 0.07 0.95 1 5.00
172 INT308169 Negative_regulation of Mapk14 Negative_regulation of Ltp 1 0.01 0.79 0.95 5.00
173 INT36683 Gh1 Regulation of Gnrhr 3 0.08 1.25 0.95 5.00
174 INT215584 P2rx1 Regulation of Localization of Gabrg1 1 0.01 0 0.92 5.00
175 INT309708 Palm Regulation of Positive_regulation of Penk 1 0.19 1.25 0.91 5.00
176 INT279166 Binding of Cyp3a23/3a1 and Nr3c2 1 0.00 0.61 0.9 5.00
177 INT218062 Abat Negative_regulation of Ctse 1 0.03 0.25 0.89 5.00
178 INT339318 Ngf Positive_regulation of Pik3cg 1 0.02 0.69 0.87 5.00
179 INT44442 GNRH1 Positive_regulation of Localization of PLOD1 3 0.50 0.78 0.86 5.00
180 INT199499 Il6 Positive_regulation of Transcription of Oprm1 1 0.01 0.8 0.86 5.00
181 INT199492 Il6 Positive_regulation of Transcription of Oprm1 1 0.01 0.81 0.86 5.00
182 INT199487 Il6 Positive_regulation of Oprm1 1 0.01 0.8 0.86 5.00
183 INT199491 Il6 Positive_regulation of Positive_regulation of Il6 1 0.00 0.81 0.86 5.00
184 INT199500 Il6 Positive_regulation of Oprm1 1 0.01 0.8 0.85 5.00
185 INT271193 Creb1 Regulation of Bdnf 1 0.15 0.28 0.81 5.00
186 INT235087 NOS1 Positive_regulation of Localization of ABAT 1 0.02 0.61 0.81 5.00
187 INT262572 Ngf Positive_regulation of Mapk1 2 0.04 0.52 0.81 5.00
188 INT262564 Ngf Positive_regulation of Pik3r1 1 0.08 0.36 0.8 5.00
189 INT339291 Casp1 Positive_regulation of Il1 2 0.12 1.63 0.8 5.00
190 INT262579 Ngf Positive_regulation of Prkca 1 0.07 0.36 0.8 5.00
191 INT262582 F2rl1 Regulation of Positive_regulation of Prkca 1 0.03 0.58 0.78 5.00
192 INT199495 Il4 Positive_regulation of Positive_regulation of Oprm1 1 0.00 0.98 0.78 5.00
193 INT261834 Itpr3 Positive_regulation of Prkca 2 0.01 0.33 0.78 5.00
194 INT262562 F2rl1 Regulation of Trpv1 1 0.12 0.58 0.77 5.00
195 INT199476 Il4 Positive_regulation of Transcription of Stat6 1 0.01 0.97 0.77 5.00
196 INT262563 Negative_regulation of Pax3 Regulation of Calca 1 0.01 0.75 0.76 5.00
197 INT262569 Pax3 Regulation of Calca 1 0.00 0.75 0.76 5.00
198 INT262577 Localization of Ngf Positive_regulation of Positive_regulation of Mapk14 1 0.05 0.92 0.75 5.00
199 INT308176 TNF Regulation of Tnfrsf1a 1 0.05 1.19 0.75 5.00
200 INT262578 Prkaca Positive_regulation of Localization of Calca 1 0.03 0.71 0.75 5.00

Single Events

The table below shows the top 200 pain related interactions that have been reported for Locus ceruleus. They are ordered first by their pain relevance and then by number of times they were reported in Locus ceruleus. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT5202 Positive_regulation of Gene_expression of Fos 1163 0.70 319.28 684 100.00
2 INT5228 Positive_regulation of Fos 934 0.70 209.8 503.87 100.00
3 INT218 Positive_regulation of Th 245 0.70 40.5 120.1 100.00
4 INT1303 Negative_regulation of Npr1 278 0.55 35.1 156.78 100.00
5 INT7327 Regulation of Th 164 0.62 29.67 110.14 100.00
6 INT24989 Positive_regulation of Cfp 125 0.61 29.55 64.9 100.00
7 INT66611 Localization of Cfp 22 0.65 7.04 14.64 100.00
8 INT217 Negative_regulation of Th 134 0.59 26.83 62.63 100.00
9 INT6056 Negative_regulation of Gene_expression of Fos 601 0.59 193.05 386.84 100.00
10 INT292 Localization of Penk 876 0.81 88.44 669.14 100.00
11 INT5509 Positive_regulation of Localization of Crh 91 0.70 30.65 53.92 100.00
12 INT2085 Positive_regulation of LH 441 0.70 60.15 191.02 100.00
13 INT5591 Regulation of Gene_expression of Fos 425 0.62 129.06 265.78 100.00
14 INT83818 Positive_regulation of Localization of Cfp 5 0.32 3.6 4.33 100.00
15 INT14306 Positive_regulation of Gal 36 0.70 21.66 18.51 100.00
16 INT2229 Positive_regulation of Man2a2 50 0.69 7.47 30.33 100.00
17 INT1351 Gene_expression of Pag1 131 0.57 89.48 98.76 100.00
18 INT88617 Positive_regulation of Gene_expression of Creb1 90 0.69 51.69 44.29 100.00
19 INT84495 Positive_regulation of Positive_regulation of Ephb1 85 0.70 46.12 54.11 100.00
20 INT107248 Negative_regulation of Gene_expression of Creb1 26 0.58 9.24 13.41 100.00
21 INT4459 Positive_regulation of Arc 74 0.69 33.61 28.29 100.00
22 INT7779 Negative_regulation of Adra2a 47 0.58 9.45 28 100.00
23 INT57245 Negative_regulation of Positive_regulation of Caprin2 1 0.01 1.03 1.27 100.00
24 INT5380 Positive_regulation of Gene_expression of Fos 243 0.70 105.65 131.05 100.00
25 INT82906 Positive_regulation of Binding of Gal 3 0.70 0.33 4.32 100.00
26 INT48496 Regulation of Transcription of Th 16 0.54 2.29 10.02 100.00
27 INT20914 Positive_regulation of Snai1 13 0.41 3.41 7.69 100.00
28 INT16714 Regulation of Creb1 64 0.62 22.23 33.56 100.00
29 INT5502 Positive_regulation of Gene_expression of Crh 69 0.70 43.06 42.23 100.00
30 INT5507 Regulation of Localization of Crh 57 0.61 8.43 30.26 100.00
31 INT167457 Negative_regulation of Gene_expression of Tph2 5 0.57 2.27 5.9 100.00
32 INT771 Regulation of Nts 93 0.61 13.13 53.57 100.00
33 INT10168 Positive_regulation of Localization of Gtf3a 16 0.60 3.55 3.75 100.00
34 INT2649 Regulation of Calca 433 0.62 146.05 330.95 100.00
35 INT102510 Negative_regulation of Gene_expression of B3galt6 1 0.29 0.58 2.11 100.00
36 INT60388 Gene_expression of Helt 90 0.07 19.18 41.72 100.00
37 INT12569 Localization of Oprd1 94 0.81 23.81 104.56 100.00
38 INT89250 Positive_regulation of Il11ra1 8 0.63 3.99 2.27 100.00
39 INT113848 Regulation of mPB 1 0.00 0 1.55 100.00
40 INT71363 Binding of Rvm 9 0.31 3.23 10.83 100.00
41 INT8525 Regulation of Positive_regulation of Fos 9 0.60 4.04 5.75 100.00
42 INT28728 Regulation of Cfp 49 0.46 13.15 21.43 100.00
43 INT83819 Regulation of Localization of Cfp 1 0.18 0.47 0.54 100.00
44 INT83817 Regulation of Enc1 5 0.14 2.37 2.04 100.00
45 INT83816 Localization of Enc1 1 0.06 0.47 0.54 100.00
46 INT26416 Regulation of APRT 2 0.44 0.67 1.74 100.00
47 INT7114 Positive_regulation of Ltp 1192 0.62 290.76 755.77 100.00
48 INT7569 Positive_regulation of Transcription of Th 19 0.70 2.6 6.17 100.00
49 INT105185 Negative_regulation of Gene_expression of Oprk1 9 0.42 3.53 7.53 100.00
50 INT4798 Gene_expression of Nts 169 0.77 29.56 86.04 100.00
51 INT74058 Gene_expression of Nos1 260 0.78 80.04 95.71 100.00
52 INT5498 Positive_regulation of Positive_regulation of Crh 19 0.70 9.82 7.97 100.00
53 INT7884 Regulation of Localization of Oxt 102 0.62 7.95 61.71 100.00
54 INT2421 Positive_regulation of Positive_regulation of Penk 97 0.69 13.38 55.32 100.00
55 INT2156 Positive_regulation of Positive_regulation of LH 33 0.69 3.18 14.33 100.00
56 INT27171 Localization of Maoa 7 0.73 2.32 3.1 100.00
57 INT52690 Positive_regulation of Ptgs2 65 0.68 39.51 30.02 100.00
58 INT7623 Regulation of Regulation of Th 11 0.44 1.31 5.16 100.00
59 INT4358 Positive_regulation of Localization of Avp 195 0.70 30.79 77.58 100.00
60 INT160383 Positive_regulation of Gene_expression of Gnao1 1 0.47 0.49 0.94 100.00
61 INT90114 Regulation of Gene_expression of Nos1 18 0.62 6.38 10.52 100.00
62 INT19949 Regulation of Positive_regulation of Fos 36 0.60 6.11 22.05 100.00
63 INT33944 Regulation of Helt 13 0.24 2.86 8.49 100.00
64 INT63029 Gene_expression of Vtn 4 0.14 2.8 1.8 100.00
65 INT5200 Gene_expression of Fos 3083 0.78 894.43 1639.02 99.98
66 INT720 Positive_regulation of POMC 807 0.70 237.37 353.83 99.98
67 INT73916 Gene_expression of Esr1 58 0.77 26.59 15.15 99.98
68 INT45365 Negative_regulation of Cfp 68 0.57 25.44 32.11 99.98
69 INT56084 Negative_regulation of SLC43A3 11 0.39 5.39 2.27 99.98
70 INT739 Negative_regulation of POMC 358 0.59 102.28 166.77 99.98
71 INT5379 Gene_expression of Fos 656 0.78 255.5 292.54 99.98
72 INT77385 Gene_expression of Esr2 18 0.75 4.69 3.92 99.98
73 INT186535 Negative_regulation of Gene_expression of Esr2 2 0.25 1.07 0.38 99.98
74 INT81419 Localization of PAG1 10 0.64 11.1 8.01 99.98
75 INT14097 Positive_regulation of Son 22 0.61 5.14 6.55 99.98
76 INT102512 Gene_expression of B3galt6 10 0.52 3.01 8.25 99.96
77 INT102508 Positive_regulation of Gene_expression of B3galt6 1 0.47 1.02 4.64 99.96
78 INT169721 Negative_regulation of Negative_regulation of Creb1 1 0.43 0.09 1.22 99.96
79 INT120688 Gene_expression of Atp6v0a2 7 0.10 7.5 4.4 99.96
80 INT89251 Positive_regulation of Transcription of Galr1 4 0.50 0.25 4.37 99.94
81 INT89249 Positive_regulation of Positive_regulation of Galr1 2 0.47 0.08 2.35 99.94
82 INT16879 Binding of Crh 72 0.48 21.65 28.43 99.92
83 INT4803 Transcription of Penk 435 0.72 59.09 182.4 99.92
84 INT7287 Positive_regulation of Transcription of Penk 103 0.70 19.81 50.37 99.92
85 INT103148 Regulation of Agtr1b 3 0.35 1.43 0.84 99.92
86 INT5957 Positive_regulation of Cpe 65 0.69 21.07 51.22 99.92
87 INT5453 Regulation of Localization of POMC 114 0.62 20.56 56.34 99.90
88 INT57244 Positive_regulation of Caprin2 5 0.13 3.44 2.39 99.90
89 INT7608 Positive_regulation of Adra2a 66 0.70 17.81 35.15 99.90
90 INT105455 Positive_regulation of Rgs4 5 0.70 0.05 3.46 99.88
91 INT14114 Binding of Adra2a 30 0.48 4.24 18.53 99.88
92 INT38731 Localization of Trpv1 138 0.81 52.73 90.49 99.88
93 INT102509 Negative_regulation of Vta1 5 0.29 0.87 5.62 99.88
94 INT67 Negative_regulation of Ddc 66 0.59 15.34 28.96 99.86
95 INT16258 Gene_expression of Ntf3 121 0.78 53.93 59.03 99.84
96 INT16260 Gene_expression of Bdnf 671 0.78 283.44 339.1 99.84
97 INT108371 Positive_regulation of Cnnm1 8 0.53 3.11 5.58 99.84
98 INT5300 Regulation of Insr 54 0.60 11.33 29.26 99.84
99 INT16253 Positive_regulation of Gene_expression of Bdnf 196 0.70 92.67 113.01 99.84
100 INT75224 Positive_regulation of Gene_expression of Ntf3 23 0.69 11.79 13.08 99.84
101 INT738 Regulation of POMC 459 0.62 111.19 243.74 99.84
102 INT5895 Gene_expression of Oprm1 525 0.78 120.67 407.29 99.84
103 INT17039 Regulation of Hr 11 0.27 5.22 2.58 99.84
104 INT451 Regulation of Oxt 142 0.62 22.07 69.42 99.84
105 INT16261 Transcription of Bdnf 101 0.72 49.41 40.64 99.84
106 INT56048 Positive_regulation of Transcription of Bdnf 24 0.70 8.33 11.83 99.84
107 INT75996 Transcription of Ntf3 13 0.67 4.03 3.88 99.84
108 INT5116 Gene_expression of IL2 670 0.78 291.13 146.69 99.84
109 INT26643 Negative_regulation of Positive_regulation of Th 12 0.59 1.26 7.74 99.84
110 INT94985 Regulation of Gene_expression of Arrb2 2 0.40 0.43 4.2 99.84
111 INT4781 Gene_expression of TH 68 0.73 26.92 24.01 99.84
112 INT3971 Positive_regulation of Alb 175 0.70 98.46 36.45 99.84
113 INT108941 Regulation of Gene_expression of Arrb1 1 0.54 0.25 2.09 99.84
114 INT43327 Positive_regulation of ADRA2A 3 0.46 1.54 1.53 99.84
115 INT55036 Regulation of Adcy8 3 0.44 0.85 2.56 99.84
116 INT74059 Positive_regulation of Gene_expression of Nos1 55 0.70 11.5 21.39 99.84
117 INT1562 Localization of Crh 499 0.81 126.74 236.68 99.82
118 INT797 Regulation of Penk 812 0.62 111.13 542.24 99.82
119 INT182658 Regulation of Gene_expression of Rem1 4 0.20 2.55 0.47 99.82
120 INT14843 Gene_expression of Gabrg1 301 0.77 62.63 139.16 99.82
121 INT37205 Localization of LAMTOR1 1 0.02 0 0.31 99.82
122 INT1665 Positive_regulation of Pag1 270 0.68 186.63 229.87 99.80
123 INT5567 Positive_regulation of Pkia 12 0.69 1.67 14.1 99.80
124 INT25199 Positive_regulation of Positive_regulation of Pkia 1 0.41 0.18 1.58 99.80
125 INT7765 Positive_regulation of Positive_regulation of Man2a2 9 0.45 1.62 5.81 99.80
126 INT167477 Regulation of TREX1 1 0.24 1.04 1.12 99.80
127 INT169766 Negative_regulation of S100a1 1 0.15 0 0.77 99.80
128 INT169760 Negative_regulation of Mir16-1 1 0.47 0 0.77 99.80
129 INT1044 Negative_regulation of Localization of LH 358 0.59 25.95 151.31 99.78
130 INT232667 Binding of Pd 17 0.16 20.76 3.58 99.78
131 INT140621 Localization of Hcrt 7 0.73 2.6 1.64 99.78
132 INT30317 Regulation of TH 14 0.43 7.27 5.38 99.78
133 INT111512 Negative_regulation of Galr1 4 0.59 6.45 3.61 99.78
134 INT25198 Regulation of Pkia 3 0.27 0.51 3.31 99.76
135 INT6926 Regulation of Pag1 72 0.39 55.79 65.09 99.76
136 INT48767 Negative_regulation of NOS1 312 0.59 154.25 90.32 99.74
137 INT237875 Gene_expression of Epn1 1 0.10 1.26 2.4 99.74
138 INT92669 Gene_expression of Bdnf 309 0.78 178.26 116.68 99.74
139 INT102903 Regulation of Gene_expression of Bdnf 35 0.62 20.1 17.42 99.74
140 INT259519 Negative_regulation of sld 1 0.10 0.47 1.97 99.72
141 INT48832 Positive_regulation of Grip2 48 0.69 12.13 25.99 99.72
142 INT15796 Regulation of IL2 66 0.61 25.43 20.62 99.72
143 INT248 Positive_regulation of Localization of GH1 137 0.69 49.25 32.92 99.72
144 INT53964 Negative_regulation of Prkaca 131 0.58 38.76 69.52 99.70
145 INT71151 Regulation of NTRK1 10 0.62 6.65 6.21 99.70
146 INT71476 Negative_regulation of Regulation of Creb1 1 0.18 0.17 1.06 99.70
147 INT96504 Negative_regulation of SLC18A2 5 0.36 2.07 4.62 99.70
148 INT96503 Negative_regulation of SLC18A1 1 0.41 0.45 1.17 99.70
149 INT102387 Negative_regulation of Transcription of Adora2a 1 0.09 0.24 0.37 99.70
150 INT57939 Negative_regulation of Gene_expression of Adora2a 4 0.36 0.15 2.02 99.70
151 INT438 Gene_expression of Crh 376 0.78 159.11 169.17 99.68
152 INT3439 Localization of Abat 1017 0.78 112.39 727.06 99.68
153 INT63932 Positive_regulation of Ephb1 537 0.70 259.67 296.14 99.68
154 INT5497 Positive_regulation of Crh 299 0.70 125.54 131.14 99.68
155 INT350 Localization of Th 79 0.80 10.26 41.17 99.68
156 INT6293 Gene_expression of Oprm1 312 0.78 48.73 215.61 99.68
157 INT4259 Positive_regulation of Npr1 262 0.70 49.37 123.11 99.68
158 INT728 Positive_regulation of Penk 1068 0.70 186.9 636.87 99.68
159 INT49651 Gene_expression of Creb1 276 0.78 114.77 111.96 99.68
160 INT3440 Negative_regulation of Localization of Abat 221 0.57 33.94 180.36 99.68
161 INT7326 Transcription of Th 83 0.72 13.5 35.33 99.68
162 INT30817 Gene_expression of Th 142 0.76 33.56 38.12 99.68
163 INT1281 Negative_regulation of Maoa 203 0.59 22.47 91.66 99.68
164 INT4829 Positive_regulation of Localization of Abat 199 0.55 20.91 150.48 99.68
165 INT24240 Positive_regulation of Th 60 0.70 9.92 20.18 99.68
166 INT5514 Negative_regulation of Localization of Crh 64 0.58 8.12 29.29 99.68
167 INT51164 Gene_expression of Galr1 12 0.78 6.3 7.3 99.68
168 INT109034 Gene_expression of Eif2ak3 37 0.77 17.11 14.19 99.68
169 INT78567 Positive_regulation of Gene_expression of Th 25 0.68 5.32 10.75 99.68
170 INT51165 Binding of Gal 10 0.48 2.56 8.41 99.68
171 INT8781 Regulation of Prlh 6 0.45 0.67 3.58 99.68
172 INT5906 Negative_regulation of Oprm1 125 0.59 19.58 101.57 99.68
173 INT64202 Positive_regulation of Trpv1 643 0.70 249.66 397.42 99.68
174 INT150678 Positive_regulation of Gene_expression of Eif2ak3 17 0.69 6.64 8.99 99.68
175 INT5059 Positive_regulation of TNF 1050 0.70 896.51 322.81 99.68
176 INT6436 Positive_regulation of Positive_regulation of Fos 101 0.70 18.71 57.96 99.68
177 INT8650 Gene_expression of Gal 152 0.78 61.97 81.72 99.68
178 INT1166 Negative_regulation of Dbh 56 0.59 12.54 28.26 99.68
179 INT6483 Gene_expression of TNF 3152 0.78 2515.62 929.82 99.68
180 INT24525 Regulation of Gal 19 0.60 10.17 9.57 99.68
181 INT4890 Gene_expression of Ppt1 51 0.77 8.93 21.83 99.68
182 INT115649 Gene_expression of Camk2a 95 0.78 33.22 38 99.68
183 INT7885 Positive_regulation of Localization of Oxt 160 0.70 14.36 87.7 99.68
184 INT6482 Positive_regulation of Gene_expression of TNF 659 0.70 569.88 210 99.68
185 INT115650 Positive_regulation of Gene_expression of Camk2a 37 0.70 17.68 15.73 99.68
186 INT26415 Regulation of Phosphorylation of PKIA 1 0.01 0.06 2.04 99.68
187 INT26417 Phosphorylation of PKIA 1 0.02 0.06 2.04 99.68
188 INT4282 Regulation of Msr1 11 0.45 2.51 5.75 99.68
189 INT51163 Gene_expression of Gal 119 0.78 67.48 49.23 99.68
190 INT48923 Gene_expression of Ephb1 211 0.77 106.23 109.9 99.68
191 INT1898 Regulation of Crh 220 0.62 61.33 102.64 99.68
192 INT13716 Positive_regulation of TH 33 0.68 19.11 16 99.68
193 INT92972 Positive_regulation of Gene_expression of Galr1 2 0.69 0.08 1.46 99.68
194 INT7944 Positive_regulation of Fos 193 0.70 60.69 98.31 99.68
195 INT2910 Regulation of Abat 169 0.62 36.95 153.53 99.68
196 INT5540 Positive_regulation of Oprm1 344 0.70 76.77 319.71 99.68
197 INT6051 Positive_regulation of Transcription of Fos 27 0.69 6.3 11.48 99.68
198 INT47894 Regulation of Npy1r 5 0.33 3.08 4.27 99.68
199 INT49147 Gene_expression of Npy1r 27 0.76 6.57 14.75 99.68
200 INT28715 Negative_regulation of Regulation of Crh 7 0.43 0.97 3.06 99.68
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