P:MU agonist

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pChart

Pain Term
Category Family
Synonyms Mu Agonists, Opioid Agonist, Opioid Agonists
Pain Specific Yes
Documents 3400
Hot Single Events 200
Hot Interactions 142

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported for MU agonist. They are ordered first by their pain relevance and then by number of times they were reported for MU agonist. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT113714 Em Positive_regulation of tf 1 0.32 0 2.5 100.00
2 INT113715 Msh3 Positive_regulation of tf 1 0.11 0 2.47 100.00
3 INT52759 Oprd1 Regulation of Sptan1 1 0.03 0 0.9 100.00
4 INT52760 Oprd1 Regulation of Drd1a 1 0.02 0 0.9 100.00
5 INT53052 ANTXRL Negative_regulation of Negative_regulation of ADCY1 1 0.01 0.66 0.99 100.00
6 INT72146 POMC Positive_regulation of Phosphorylation of MYOT 1 0.00 0.25 0.65 100.00
7 INT25837 Binding of Dbp and Oprl1 1 0.10 0 1.05 100.00
8 INT64259 Binding of Gtpbp4 and Ptprg 1 0.06 0 1.1 100.00
9 INT86644 Binding of OPRD1 and DLL1 1 0.28 0.17 0.58 100.00
10 INT122311 Sst Regulation of Kcnk3 1 0.14 0.28 0.29 100.00
11 INT45376 Binding of Cpe and Mme 1 0.07 0.32 2.13 99.96
12 INT21543 Binding of Oprd1 and Cish 2 0.09 0.15 0.78 99.88
13 INT65060 Slc3a1 Positive_regulation of Jun 1 0.00 0 0.37 99.86
14 INT65059 Slc3a1 Positive_regulation of Nfkb1 1 0.00 0 0.37 99.86
15 INT72690 Binding of Hrh1 and Slc3a1 1 0.00 0.29 0.45 99.82
16 INT90807 EGF Positive_regulation of Oprd1 1 0.00 0.39 0.39 99.62
17 INT63488 Sptan1 Positive_regulation of Rtcd1 1 0.03 0.34 0.91 99.46
18 INT104710 Em Positive_regulation of Rbm39 1 0.02 0.07 1.76 99.44
19 INT33464 Binding of DMRT1 and Penk 1 0.28 0.16 0.81 99.42
20 INT52761 Dll1 Regulation of Sptan1 1 0.07 0 0.89 99.40
21 INT52762 Dll1 Regulation of Drd1a 1 0.10 0 0.89 99.40
22 INT142454 Npff Positive_regulation of Gtpbp4 1 0.56 0 0.78 99.24
23 INT142455 Binding of Npff and Gtpbp4 1 0.40 0 0.78 99.24
24 INT122312 Prkaca Regulation of Kcnk3 1 0.13 0.28 0.28 99.24
25 INT104709 Msh3 Positive_regulation of Rbm39 1 0.01 0.07 1.76 99.20
26 INT302119 Positive_regulation of Binding of Oprm1 and Ppp1r9b 1 0.02 0 0.77 99.20
27 INT21534 Binding of Oprd1 and Il1 1 0.00 0 0.84 98.96
28 INT302118 Binding of Oprm1 and Ppp1r9b 2 0.24 0.26 3.45 98.88
29 INT60783 Binding of Oprd1 and Cck 1 0.26 0.47 1.09 98.84
30 INT63584 Oprm1 Positive_regulation of Hrasls 1 0.00 0 0.29 98.68
31 INT67663 Ins1 Positive_regulation of Ntrk2 1 0.00 0.19 2.59 98.64
32 INT96307 Binding of Pnoc and Adarb1 1 0.12 0.37 0.77 98.64
33 INT82038 Positive_regulation of Akr1d1 Positive_regulation of Phosphorylation of Ppp1r1b 1 0.02 0 0.64 98.64
34 INT106394 MAPK3 Positive_regulation of ADRBK1 1 0.48 0.06 0.53 98.56
35 INT32182 PRL Regulation of GHRH 2 0.17 0 1.12 98.48
36 INT33415 KNG1 Positive_regulation of GBP1 1 0.02 0.43 0.51 98.16
37 INT134363 Prkcg Regulation of ADCY2 1 0.00 0.14 1.7 97.96
38 INT31439 Penk Positive_regulation of Localization of Prl 8 0.55 0.23 6.24 97.44
39 INT26198 Positive_regulation of Crh Positive_regulation of Localization of POMC 1 0.38 0 0.7 97.04
40 INT5486 Oprd1 Regulation of Cck 1 0.21 0 2.16 96.48
41 INT121464 Negative_regulation of Oprm1 Positive_regulation of Dnm2 1 0.34 0 1.26 96.40
42 INT14095 Binding of Vsig2 and Coq10a 2 0.33 1.98 4.55 96.28
43 INT86589 Oprd1 Regulation of Localization of Pomc 1 0.18 0 0.9 96.28
44 INT15344 Oprd1 Regulation of Localization of Tacr3 1 0.00 0 0.76 96.28
45 INT66196 OPRK1 Negative_regulation of Oprd1 1 0.00 0 0.43 96.08
46 INT149559 Tgfb1 Positive_regulation of Gene_expression of Ccr5 1 0.00 0 0.88 95.76
47 INT149560 Tgfb1 Positive_regulation of Ccr5 1 0.00 0 0.88 95.76
48 INT149562 Tgfb1 Positive_regulation of CXCL10 1 0.00 0 0.88 95.76
49 INT149564 Tgfb1 Positive_regulation of Gene_expression of CXCL10 1 0.00 0 0.88 95.76
50 INT149561 Tgfb1 Positive_regulation of Gene_expression of CCL2 1 0.00 0 0.83 95.76
51 INT149563 Tgfb1 Positive_regulation of CCL2 1 0.00 0 0.83 95.76
52 INT149558 Tgfb1 Positive_regulation of Gene_expression of Cxcr4 1 0.00 0 0.82 95.76
53 INT149557 Tgfb1 Positive_regulation of Gene_expression of Ccl5 1 0.00 0 0.82 95.76
54 INT7888 Oprl1 Regulation of Localization of Avp 4 0.49 0.25 2.63 95.44
55 INT7887 Oprl1 Regulation of Localization of Oxt 2 0.16 0 1.23 95.44
56 INT152390 Negative_regulation of Binding of JUN and OPRM1 1 0.13 0.14 0.94 95.04
57 INT152389 Negative_regulation of Binding of NFKB1 and OPRM1 1 0.05 0.14 0.94 95.04
58 INT99138 Coq10a Regulation of Insrr 1 0.01 0.73 1.81 94.72
59 INT152388 Binding of NFKB1 and OPRM1 1 0.04 0.14 0.94 94.72
60 INT152387 Binding of JUN and OPRM1 1 0.15 0.14 0.94 94.72
61 INT18659 Plat Regulation of ZC3H12D 1 0.02 0.1 1.29 94.12
62 INT21536 Binding of Il2 and Il1 1 0.28 0 1.47 94.08
63 INT21535 Binding of Il2 and Il1f5 1 0.13 0 0.73 93.84
64 INT106243 Oprm1 Regulation of Gene_expression of IL8 1 0.00 0 0.45 93.44
65 INT63490 Negative_regulation of Dio1 Positive_regulation of Rtcd1 1 0.01 0.58 1.51 93.12
66 INT63489 Dio1 Positive_regulation of Rtcd1 1 0.01 0.58 1.51 93.12
67 INT34271 Positive_regulation of WAS Positive_regulation of Oprd1 1 0.01 0 0.91 93.12
68 INT34273 WAS Regulation of Oprd1 1 0.00 0 0.91 93.12
69 INT34272 WAS Positive_regulation of Oprd1 1 0.01 0 0.91 93.12
70 INT2161 Gnrh1 Positive_regulation of Localization of LH 33 0.73 0.87 14.34 93.08
71 INT126614 Ppyr1 Negative_regulation of Phosphorylation of Stat5a 1 0.27 0.1 0.64 93.08
72 INT53139 Binding of Htr1a and Kcnj3 1 0.37 0 0.42 92.48
73 INT36597 Hrh1 Regulation of Rtcd1 1 0.04 0.36 1.01 92.28
74 INT67445 Oprd1 Regulation of Localization of POMC 1 0.00 0 0.39 92.28
75 INT67443 Oprd1 Regulation of Ugt1a10 1 0.00 0 0.36 92.28
76 INT78580 Binding of Adra2b and Oprd1 1 0.01 0.07 0.57 92.20
77 INT106396 DYT10 Positive_regulation of MAPK3 1 0.50 0 0.42 92.04
78 INT106395 DYT10 Positive_regulation of ADRBK2 1 0.44 0 0.42 92.04
79 INT140280 Negative_regulation of Binding of Adora2a and Grina 1 0.21 0.64 0.82 91.96
80 INT140281 Binding of Adora2a and Grina 1 0.19 0.64 0.82 91.96
81 INT64127 Igfbp2 Regulation of Localization of Avp 1 0.39 0.19 0.9 91.76
82 INT41152 Binding of Penk and Slc3a1 3 0.12 0.11 2.91 91.36
83 INT61687 Binding of Pah and Slc3a1 1 0.00 0.11 1.09 91.36
84 INT76776 Binding of Pnoc and Ptprg 2 0.02 0 2.29 91.20
85 INT315180 Gene_expression of Mors1 Positive_regulation of Gene_expression of Oprm1 1 0.03 0.48 1.64 91.12
86 INT315181 Gene_expression of Mors1 Positive_regulation of Oprm1 1 0.03 0.48 1.64 91.12
87 INT143492 OPRL1 Regulation of PNOC 1 0.05 0 0.99 91.04
88 INT117199 Rgs1 Regulation of Rgs19 1 0.02 0.16 0.56 90.96
89 INT12897 Penk Regulation of Pdia4 1 0.07 0 0.5 90.96
90 INT106392 ADRBK1 Regulation of Negative_regulation of OPRL1 1 0.27 0.06 0.52 90.48
91 INT89470 CGA Regulation of Gene_expression of Lhcgr 1 0.00 0 0.23 90.40
92 INT89468 Fk Regulation of Gene_expression of Lhcgr 1 0.01 0 0.23 90.40
93 INT82041 Positive_regulation of Adora2a Positive_regulation of Phosphorylation of Ppp1r1b 1 0.12 0 0.72 90.24
94 INT121465 Binding of Dnm2 and Oprm1 1 0.23 0 1.24 90.16
95 INT79372 Calca Regulation of Pnoc 1 0.34 0 1.07 90.08
96 INT211747 Negative_regulation of Binding of Oprm1 and Mors1 1 0.09 0 1.86 90.00
97 INT51543 Positive_regulation of Binding of Oxt and Penk 1 0.56 0.05 0.94 89.36
98 INT51542 Negative_regulation of Binding of Avp and Penk 1 0.46 0.05 0.94 89.36
99 INT51544 Binding of Oxt and Penk 1 0.54 0.05 0.94 89.36
100 INT51541 Positive_regulation of Binding of Avp and Penk 1 0.74 0.05 0.94 89.36
101 INT51545 Binding of Avp and Penk 1 0.51 0.05 0.94 89.36
102 INT136141 Hsd11b1 Positive_regulation of Gene_expression of Agrp 1 0.64 0.2 0.47 88.96
103 INT60867 Binding of G2e3 and Gpm6a 2 0.01 0.1 1.93 88.88
104 INT117677 Binding of MATN3 and OPRL1 1 0.26 0.07 0.68 88.76
105 INT211746 Binding of Oprm1 and Mors1 1 0.08 0 1.78 88.32
106 INT19633 GNRH1 Regulation of Localization of CGA 4 0.44 0.82 1.33 88.16
107 INT21111 Binding of Oprm1 and RGD735065 1 0.02 0 0.37 88.16
108 INT84434 Calca Negative_regulation of Negative_regulation of Hrh1 1 0.06 0.19 1.44 87.64
109 INT64883 Ptger2 Positive_regulation of Ina 1 0.03 1.26 3.64 87.40
110 INT64885 Ptger2 Positive_regulation of Ptger2 Positive_regulation of Ina 1 0.01 0.19 0.89 87.40
111 INT145906 Elane Regulation of Transcription of Oprm1 1 0.10 0.14 1.04 86.72
112 INT30359 Pomc Regulation of Localization of Oxt 1 0.03 0 1.13 86.32
113 INT72386 Egf Positive_regulation of Phosphorylation of Shc1 1 0.09 0.18 0.93 86.24
114 INT56895 Binding of GNRH1 and NCOR2 1 0.02 0 0.76 85.84
115 INT21570 Binding of Cck and Mapk8 1 0.06 0 1.6 85.56
116 INT114324 RAF1 Positive_regulation of Phosphorylation of ADCY6 1 0.02 0.05 0.85 85.00
117 INT114323 Binding of ADCY6 and RAF1 1 0.02 0.05 0.85 85.00
118 INT98737 Src Negative_regulation of Tk1 1 0.22 0.15 0.5 84.96
119 INT98735 Src Negative_regulation of Egf 1 0.26 0.15 0.5 84.96
120 INT98734 Egf Negative_regulation of Tk1 1 0.13 0.15 0.49 84.80
121 INT76165 IGKV2-30 Positive_regulation of Phosphorylation of Oprm1 1 0.00 0.08 1.22 84.44
122 INT21267 Cck Negative_regulation of Binding of Oprd1 1 0.50 0 1.12 84.40
123 INT82040 Adora2a Positive_regulation of Phosphorylation of Ppp1r1b 1 0.11 0 0.75 84.40
124 INT82039 Akr1d1 Positive_regulation of Phosphorylation of Ppp1r1b 1 0.02 0 0.74 84.40
125 INT110727 Binding of HBM and LTF 1 0.00 0 0.41 84.40
126 INT30463 Binding of PDYN and Penk 2 0.01 0 1.5 84.00
127 INT89469 Fk Positive_regulation of Gene_expression of Lhcgr 1 0.01 0 0.24 83.84
128 INT76163 Prkaca Positive_regulation of Phosphorylation of Oprm1 1 0.02 0.08 1.22 83.40
129 INT110726 Binding of ALB and LTF 1 0.01 0 0.81 83.28
130 INT134971 Positive_regulation of OPRK1 Positive_regulation of Binding of OPRK1 and SP1 1 0.00 0 1.07 83.04
131 INT111936 Binding of PIK3CA and PTK2 1 0.19 0.67 0.65 83.00
132 INT111937 Binding of PIK3CG and PTK2 1 0.08 0.67 0.64 83.00
133 INT134049 Jak2 Positive_regulation of Gsk3b 1 0.37 0.22 0.77 81.60
134 INT134043 Jak2 Positive_regulation of Akt1 1 0.31 0.22 0.76 80.96
135 INT93709 Positive_regulation of Oprd1 Regulation of Calm3 1 0.01 0 0.74 80.96
136 INT134051 Jak2 Positive_regulation of Stat3 1 0.44 0.22 0.76 80.76
137 INT80877 Negative_regulation of PCDHB17 Negative_regulation of ADCY1 1 0.01 0.08 0.84 80.60
138 INT80878 PCDHB17 Negative_regulation of ADCY1 1 0.01 0.08 0.84 80.60
139 INT105877 Positive_regulation of Binding of Ins1 and Oprm1 1 0.21 0.67 0.28 80.60
140 INT105872 Binding of Ins1 and Oprm1 1 0.16 0.58 0.27 80.60
141 INT134970 Positive_regulation of Binding of OPRK1 and SP1 1 0.00 0 1.05 80.28
142 INT84607 Oprl1 Regulation of Adrb3 1 0.19 0.25 0.24 80.24
143 INT93708 Oprd1 Regulation of Calm3 1 0.01 0 0.73 80.00
144 INT134969 Binding of OPRK1 and SP1 1 0.00 0 1.04 79.88
145 INT107331 Binding of PPBP and Adarb1 1 0.01 0 3.67 79.60
146 INT102364 BRD1 Positive_regulation of Twist1 1 0.00 0 0.47 79.60
147 INT149169 Binding of Oprm1 and Atxn2l 1 0.07 0 0.5 79.44
148 INT96301 Olr1742 Negative_regulation of Gene_expression of Tnf 1 0.14 0 0.74 79.12
149 INT115985 Cpe Positive_regulation of Binding of Gnas 1 0.00 0.17 1.28 79.08
150 INT164665 Adarb1 Positive_regulation of Negative_regulation of Tens1 1 0.03 0.42 1.97 78.36
151 INT308894 Adp Regulation of P2ry1 1 0.05 0.49 0.53 78.32
152 INT239537 CXCR2 Regulation of MYC 1 0.15 0.05 0.29 78.24
153 INT146352 Binding of Rgs14 and Mors1 1 0.23 0.27 1.17 77.96
154 INT93710 Oprm1 Positive_regulation of Gene_expression of Calm3 1 0.25 0 0.73 77.76
155 INT208572 Binding of IL8 and CXCR1 6 0.33 5.2 3.08 77.04
156 INT182194 Binding of IL8 and CXCR2 10 0.56 7.14 4.16 77.04
157 INT66535 Binding of Pnoc and Oprl1 43 0.54 5.93 32.4 77.00
158 INT56892 Binding of MGP and Oprd1 1 0.05 0 0.27 76.44
159 INT115261 Gene_expression of Nos2 Positive_regulation of Positive_regulation of Npr1 1 0.05 0.67 0.31 76.24
160 INT59687 Gene_expression of Opcml Regulation of Binding of Oprd1 1 0.00 0.54 0.62 75.76
161 INT59518 YY1 Positive_regulation of SGCG 1 0.50 0.32 0.99 75.60
162 INT79532 Crh Regulation of Ugt1a10 1 0.00 0 0.76 75.44
163 INT72820 EDN3 Positive_regulation of Avp 1 0.31 0.64 0.27 75.00
164 INT64750 Binding of Oprm1 and Pck1 2 0.41 0.51 2.07 75.00
165 INT64749 Negative_regulation of Binding of Oprm1 and Pck1 1 0.47 0.21 1.27 75.00
166 INT67383 Binding of OPRK1 and Pdyn 2 0.00 0 1.25 75.00
167 INT72817 Agt Negative_regulation of Avp 1 0.07 0.34 0.14 75.00
168 INT72818 Edn3 Negative_regulation of Avp 1 0.08 0.34 0.14 75.00
169 INT19105 Olr824 Negative_regulation of Lhb 1 0.00 0 0.2 75.00
170 INT34740 BID Regulation of Gene_expression of PLOD1 1 0.01 0 0.83 75.00
171 INT72819 Regulation of EDN3 Positive_regulation of Avp 1 0.28 0.32 0.13 75.00
172 INT106837 Binding of Oprm1 and Arrb2 3 0.32 0.83 3.01 75.00
173 INT34472 Penk Regulation of Slc3a1 2 0.03 0.42 1.74 75.00
174 INT31534 Binding of Sst and Oprl1 2 0.16 0.53 1.74 75.00
175 INT75807 Gpm6a Positive_regulation of Localization of Penk 1 0.04 0 1.35 75.00
176 INT30744 Sst Regulation of Cck 1 0.28 0.43 1.27 75.00
177 INT66488 Binding of Oprl1 and Cbm4 1 0.01 0 1.17 75.00
178 INT95045 Binding of Commd3 and Oprl1 1 0.34 0 1.16 75.00
179 INT195927 Binding of Prkaca and Trpv1 1 0.07 0.28 0.92 75.00
180 INT67909 Binding of Cck and Plxna3 Positive_regulation of Cck 1 0.04 0.54 0.84 75.00
181 INT67908 Binding of Cck and Plxna3 1 0.04 0.54 0.84 75.00
182 INT139745 Positive_regulation of Binding of Oprm1 and Arrb2 1 0.28 0.14 0.81 75.00
183 INT91239 Prkaca Regulation of Negative_regulation of Oprm1 1 0.43 0 0.76 75.00
184 INT74252 Binding of Penk and Set 1 0.03 0 0.75 75.00
185 INT68540 Penk Regulation of Ndst4 1 0.00 0.35 0.5 75.00
186 INT160246 Msr1 Negative_regulation of Binding of Col11a1 and Crygs 1 0.00 0.17 0.41 75.00
187 INT160245 Binding of Col11a1 and Crygs 1 0.00 0.17 0.4 75.00
188 INT56876 Regulation of Binding of Cd36 and Gtpbp4 1 0.00 0 0.4 75.00
189 INT56875 Binding of Cd36 and Gtpbp4 1 0.00 0 0.4 75.00
190 INT239540 Binding of CXCR2 and MYC 1 0.15 0.09 0.33 74.96
191 INT107330 Binding of Adarb1 and Trh 1 0.01 0 0.65 74.72
192 INT65362 Negative_regulation of Binding of Oprl1 and Ceacam1 1 0.00 0 0.28 74.48
193 INT65363 Binding of Oprl1 and Ceacam1 1 0.00 0 0.28 74.48
194 INT73311 Binding of Oprm1 and Pdpn 1 0.08 0.71 1.06 74.04
195 INT115048 Kcnip3 Regulation of Gene_expression of Pdyn 2 0.27 0.71 1.78 73.92
196 INT115049 Crem Regulation of Gene_expression of Pdyn 1 0.20 0.32 0.96 73.92
197 INT72689 Binding of Oprd1 and Ptprg 1 0.00 0.38 0.71 73.84
198 INT76069 Binding of Oprl1 and Oprm1 1 0.07 0 0.73 73.68
199 INT97863 Binding of NOS1 and GRHPR 1 0.05 0.23 0.77 72.92
200 INT1392 Trh Regulation of Prl 15 0.29 2.47 4.29 72.60

Single Events

The table below shows the top 200 pain related interactions that have been reported for MU agonist. They are ordered first by their pain relevance and then by number of times they were reported in MU agonist. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT5979 Gene_expression of Oprd1 428 0.78 75.64 320.32 100.00
2 INT5660 Binding of Oprd1 477 0.48 71.86 342.06 100.00
3 INT26472 Regulation of Oprm1 191 0.62 35.84 173.1 100.00
4 INT796 Gene_expression of Penk 1902 0.78 275.47 1057.59 100.00
5 INT7886 Regulation of Localization of Avp 146 0.62 14.53 72.99 100.00
6 INT1414 Regulation of Oprl1 169 0.62 32.05 139.99 100.00
7 INT6824 Regulation of Gene_expression of Pdyn 114 0.62 9.48 66.73 100.00
8 INT161 Regulation of Localization of Prl 615 0.62 65.37 298.66 100.00
9 INT4207 Regulation of Avp 267 0.62 63.72 115.33 100.00
10 INT1614 Gene_expression of Oprl1 164 0.78 31.43 127.74 100.00
11 INT728 Positive_regulation of Penk 1068 0.70 186.9 636.87 100.00
12 INT768 Positive_regulation of Oprl1 179 0.70 40.05 156.93 100.00
13 INT1599 Positive_regulation of ADCY1 146 0.67 30.05 64.9 100.00
14 INT162 Regulation of Prl 794 0.62 165.01 322.24 100.00
15 INT881 Negative_regulation of Localization of Gh1 164 0.58 15.1 75.28 100.00
16 INT7884 Regulation of Localization of Oxt 102 0.62 7.95 61.71 100.00
17 INT10304 Binding of OPRK1 89 0.48 9.28 49.42 100.00
18 INT10668 Positive_regulation of Gene_expression of Oprd1 61 0.69 15.21 52.12 100.00
19 INT1530 Regulation of Gh 382 0.61 115.96 112.47 100.00
20 INT2651 Positive_regulation of Pomc 403 0.70 95.72 206.24 100.00
21 INT7845 Regulation of OPRK1 44 0.62 4.54 30.49 100.00
22 INT797 Regulation of Penk 812 0.62 111.13 542.24 100.00
23 INT1396 Binding of Penk 355 0.48 22.79 269.65 100.00
24 INT21566 Regulation of Oprk1 10 0.62 3.4 8.63 100.00
25 INT114 Binding of Oprl1 139 0.48 23 103.35 100.00
26 INT34591 Regulation of Localization of ALPP 5 0.53 1.81 2.86 100.00
27 INT5513 Negative_regulation of Pomc 295 0.59 60.9 158.63 100.00
28 INT1395 Negative_regulation of Penk 537 0.59 87.33 389.81 100.00
29 INT886 Gene_expression of Pomc 676 0.78 129.87 295.98 100.00
30 INT416 Regulation of LH 253 0.62 31.48 125.55 100.00
31 INT12392 Regulation of Slc3a1 45 0.36 7.57 25.66 100.00
32 INT69484 Positive_regulation of Gene_expression of OPRM1 75 0.70 12.86 52.27 100.00
33 INT40486 Positive_regulation of Positive_regulation of ADCY1 20 0.48 4.29 11.33 100.00
34 INT451 Regulation of Oxt 142 0.62 22.07 69.42 100.00
35 INT6382 Regulation of Binding of Oprd1 36 0.61 7 26.48 100.00
36 INT4637 Binding of Adarb1 132 0.41 14.48 67.76 100.00
37 INT91340 Regulation of Localization of BGLAP 5 0.58 2.82 2.14 100.00
38 INT77877 Regulation of P9Ehs1 13 0.38 3.31 10.04 100.00
39 INT5050 Regulation of Localization of Calca 149 0.62 41.25 148.57 100.00
40 INT12658 Regulation of Binding of Oprm1 9 0.57 2.44 14.95 100.00
41 INT16654 Gene_expression of Insrr 138 0.46 58.96 75.68 100.00
42 INT5136 Negative_regulation of PDYN 71 0.59 11.22 51.14 100.00
43 INT5116 Gene_expression of IL2 670 0.78 291.13 146.69 100.00
44 INT29651 Regulation of Pah 11 0.37 9.95 2.79 100.00
45 INT4769 Regulation of OPRD1 20 0.44 2.05 15.97 100.00
46 INT29453 Negative_regulation of Negative_regulation of RTCA 8 0.37 2.28 3.97 100.00
47 INT6179 Binding of Oprk1 37 0.48 9.24 24.83 100.00
48 INT1652 Regulation of Pomc 387 0.62 61.01 186.51 100.00
49 INT49835 Negative_regulation of Positive_regulation of Oprm1 21 0.42 4.11 20.11 100.00
50 INT847 Regulation of Lhb 131 0.61 22.08 46.54 100.00
51 INT40811 Binding of OPRL1 26 0.48 2.76 18.68 100.00
52 INT5599 Regulation of Drd2 25 0.52 3.07 13.31 100.00
53 INT1613 Binding of Nts 58 0.48 10.55 28.18 100.00
54 INT27687 Regulation of Cp 20 0.53 9.75 10.8 100.00
55 INT1457 Negative_regulation of Binding of Penk 40 0.57 0.25 34.24 100.00
56 INT62920 Regulation of Gnai1 3 0.52 0.08 4.78 100.00
57 INT121950 Regulation of Gene_expression of Oprk1 1 0.45 0.18 0.6 100.00
58 INT18585 Regulation of Ugt1a10 4 0.03 0.54 2.69 100.00
59 INT53433 Gene_expression of Igk 8 0.75 1.34 4.18 100.00
60 INT1510 Binding of PDYN 94 0.48 4.68 56.44 100.00
61 INT18662 Negative_regulation of Binding of PDYN 5 0.57 0.34 3.58 100.00
62 INT5690 Negative_regulation of Binding of Oprd1 36 0.59 8.29 24.52 100.00
63 INT14780 Regulation of Binding of Cck 9 0.49 4.33 10.83 100.00
64 INT21438 Binding of Trim13 10 0.47 0.26 8.76 100.00
65 INT4925 Binding of Tacr1 57 0.48 17.39 38.38 100.00
66 INT13338 Regulation of Sigmar1 22 0.57 2.91 11.35 100.00
67 INT1597 Negative_regulation of Binding of Oprl1 11 0.59 1.38 6.62 100.00
68 INT33781 Binding of Pebp1 11 0.44 1.76 6.61 100.00
69 INT91238 Regulation of Negative_regulation of Oprm1 6 0.45 1.4 7.85 100.00
70 INT21550 Gene_expression of Olr1737 4 0.03 1.58 3.78 100.00
71 INT7598 Positive_regulation of Olr1737 2 0.10 0.34 1.02 100.00
72 INT12175 Positive_regulation of PDYN 86 0.69 18.27 62.04 100.00
73 INT18513 Binding of GRIN1 32 0.47 9.44 15.08 100.00
74 INT56298 Gene_expression of IL4 306 0.78 182.18 72.92 100.00
75 INT170855 Negative_regulation of GOPC 188 0.38 70.92 15.41 100.00
76 INT7765 Positive_regulation of Positive_regulation of Man2a2 9 0.45 1.62 5.81 100.00
77 INT13362 Gene_expression of NFKBIL1 12 0.59 3.79 3.99 100.00
78 INT54295 Negative_regulation of Localization of Spnb4 2 0.57 0 2.21 100.00
79 INT73112 Negative_regulation of Kcnk3 7 0.58 1.2 1.55 100.00
80 INT45105 Gene_expression of ST14 2 0.58 0.43 0.92 100.00
81 INT77355 Regulation of Transcription of Gnai1 1 0.41 0 0.84 100.00
82 INT68469 Positive_regulation of Gene_expression of NFKBIL1 1 0.00 0.51 0.79 100.00
83 INT68468 Positive_regulation of Gene_expression of Igk 1 0.00 0.51 0.79 100.00
84 INT78648 Regulation of Binding of Psen2 1 0.14 0.2 0.73 100.00
85 INT78649 Binding of Psen2 7 0.36 5.9 0.73 100.00
86 INT79100 Regulation of Alas2 1 0.01 0 0.67 100.00
87 INT75814 Regulation of Positive_regulation of PDE2A 1 0.23 0.26 0.56 100.00
88 INT63924 Regulation of Binding of Adrb1 1 0.16 0.27 0.34 100.00
89 INT5540 Positive_regulation of Oprm1 344 0.70 76.77 319.71 99.98
90 INT480 Negative_regulation of Localization of Avp 151 0.59 27.64 63.72 99.98
91 INT5940 Negative_regulation of Avp 236 0.59 67.86 101.2 99.98
92 INT880 Positive_regulation of Localization of Gh1 304 0.70 14.79 150.23 99.98
93 INT6490 Negative_regulation of ADCY1 145 0.58 26.25 70.96 99.98
94 INT5593 Positive_regulation of Gene_expression of Pdyn 114 0.70 29.1 74.46 99.98
95 INT915 Positive_regulation of PRL 342 0.70 141.96 104.31 99.98
96 INT53536 Gene_expression of Bw86 8 0.30 0.89 5.21 99.98
97 INT65054 Positive_regulation of Nfkb1 285 0.70 149.33 126.73 99.98
98 INT6796 Positive_regulation of Jun 165 0.70 37.18 49.64 99.98
99 INT739 Negative_regulation of POMC 358 0.59 102.28 166.77 99.98
100 INT4259 Positive_regulation of Npr1 262 0.70 49.37 123.11 99.98
101 INT2862 Positive_regulation of Localization of Cck 108 0.70 20.75 94.25 99.98
102 INT1309 Positive_regulation of Localization of Gnrhr 152 0.69 24.25 81.56 99.98
103 INT65210 Positive_regulation of Binding of Prkcg 6 0.70 2.71 3.65 99.98
104 INT6341 Binding of Gtpbp4 11 0.44 1.54 7.3 99.98
105 INT8732 Positive_regulation of Gene_expression of Oprm1 76 0.70 22.59 58.83 99.98
106 INT5591 Regulation of Gene_expression of Fos 425 0.62 129.06 265.78 99.98
107 INT110023 Negative_regulation of Mapk14 127 0.59 84.27 45.42 99.98
108 INT213 Negative_regulation of Localization of AVP 46 0.59 19.78 16.79 99.98
109 INT14574 Positive_regulation of Negative_regulation of ADCY1 9 0.66 2.45 4.39 99.98
110 INT25735 Positive_regulation of Dynlrb1 9 0.40 0.22 5.58 99.98
111 INT15262 Negative_regulation of Positive_regulation of Avp 22 0.58 3.28 10.81 99.98
112 INT17962 Regulation of Car2 124 0.41 33.98 22.71 99.98
113 INT18930 Positive_regulation of Hrh1 20 0.63 7.77 12.96 99.98
114 INT2005 Positive_regulation of Gene_expression of PRL 55 0.70 21.4 13.44 99.98
115 INT11436 Binding of GBP1 1 0.33 0.07 0.54 99.98
116 INT11435 Negative_regulation of Binding of GBP1 1 0.38 0.07 0.54 99.98
117 INT10340 Regulation of Localization of Oxt 30 0.60 2.55 14.3 99.98
118 INT90188 Positive_regulation of KCNJ3 7 0.67 0 5.84 99.98
119 INT231592 Binding of ADRA2B 5 0.18 0.13 1.23 99.98
120 INT46331 Negative_regulation of Gene_expression of Ptgfr 3 0.55 0.75 1.18 99.98
121 INT126992 Positive_regulation of Regulation of E2F1 1 0.58 0 0.28 99.98
122 INT5200 Gene_expression of Fos 3083 0.78 894.43 1639.02 99.96
123 INT6056 Negative_regulation of Gene_expression of Fos 601 0.59 193.05 386.84 99.96
124 INT56883 Positive_regulation of Dll1 8 0.49 3.49 12.25 99.96
125 INT9355 Binding of pcp 81 0.46 10.41 24.22 99.96
126 INT54081 Regulation of NFKBIL1 5 0.04 1.46 2.28 99.96
127 INT10555 Gene_expression of FLII 37 0.75 7.81 17.6 99.96
128 INT96744 Positive_regulation of Gene_expression of Cxcr4 14 0.68 7.92 5.75 99.96
129 INT89293 Positive_regulation of Gene_expression of CCR5 29 0.70 22.14 15 99.96
130 INT6148 Gene_expression of Nrtim1 34 0.42 10.17 12.27 99.96
131 INT92821 Positive_regulation of Gene_expression of Cd14 15 0.66 9.82 4.5 99.96
132 INT6406 Binding of Oprm1 280 0.48 40.54 226.26 99.92
133 INT6293 Gene_expression of Oprm1 312 0.78 48.73 215.61 99.92
134 INT5930 Positive_regulation of Oprm1 221 0.70 31.19 172.93 99.92
135 INT292 Localization of Penk 876 0.81 88.44 669.14 99.92
136 INT4342 Localization of ALPP 27 0.69 15.19 5.32 99.92
137 INT68260 Localization of BGLAP 34 0.78 16.04 4.63 99.92
138 INT4345 Gene_expression of Gtf3a 157 0.67 80.75 48.47 99.92
139 INT29046 Positive_regulation of Etf1 32 0.12 12.03 21.06 99.92
140 INT75815 Positive_regulation of PDE2A 10 0.40 5.1 3.15 99.92
141 INT7716 Positive_regulation of Positive_regulation of Adra2a 9 0.68 0.8 4.69 99.92
142 INT65733 Positive_regulation of Cnr1 125 0.70 40.27 67.33 99.92
143 INT60924 Regulation of Regulation of Fos 6 0.44 1.04 3.89 99.92
144 INT6437 Binding of YY1 154 0.47 26.3 90.46 99.90
145 INT30026 Regulation of Gene_expression of Odc1 2 0.62 0.09 0.85 99.90
146 INT157 Positive_regulation of Localization of Prl 790 0.70 104.54 374.78 99.88
147 INT55537 Positive_regulation of Coq10a 22 0.58 8.17 8.33 99.88
148 INT2262 Negative_regulation of Lhb 142 0.59 25.47 44.81 99.88
149 INT477 Localization of Avp 813 0.81 131.58 300.4 99.86
150 INT6042 Binding of Oprm1 248 0.48 31.77 154.34 99.86
151 INT2122 Negative_regulation of Localization of Gnrh1 226 0.59 26.92 92.04 99.86
152 INT7396 Regulation of Localization of GNRH1 81 0.62 6.57 31.31 99.86
153 INT3559 Negative_regulation of Localization of Gnrhr 73 0.58 18.89 26.41 99.86
154 INT4941 Positive_regulation of Oprd1 345 0.70 74.26 304.41 99.84
155 INT1047 Negative_regulation of LH 314 0.59 53.71 135.89 99.84
156 INT1425 Gene_expression of Rbm39 143 0.58 51.32 65.44 99.84
157 INT2229 Positive_regulation of Man2a2 50 0.69 7.47 30.33 99.84
158 INT76863 Negative_regulation of Gene_expression of OPRM1 21 0.57 6.56 13.69 99.84
159 INT58393 Positive_regulation of Localization of PTGER2 37 0.25 16.8 6 99.84
160 INT78646 Regulation of Psen2 4 0.20 1.78 1.42 99.84
161 INT58391 Positive_regulation of Negative_regulation of GNRH1 2 0.47 0 0.6 99.84
162 INT58394 Positive_regulation of Negative_regulation of PTGER2 1 0.01 0 0.32 99.84
163 INT876 Localization of Gh1 843 0.80 67.75 340.82 99.82
164 INT12602 Negative_regulation of Oprm1 190 0.59 36.11 177.85 99.82
165 INT1044 Negative_regulation of Localization of LH 358 0.59 25.95 151.31 99.82
166 INT214 Localization of AVP 370 0.81 208.51 91.09 99.82
167 INT12471 Regulation of Insrr 52 0.35 17.8 48.31 99.82
168 INT11438 Negative_regulation of GBP1 1 0.38 0.07 0.54 99.82
169 INT16450 Positive_regulation of Positive_regulation of Slc3a1 9 0.41 0 4.33 99.82
170 INT83057 Regulation of Transcription of Insrr 1 0.04 0.09 0.71 99.82
171 INT118369 Regulation of E2F1 5 0.56 3.51 0.52 99.82
172 INT126991 Regulation of Binding of E2F1 1 0.23 0 0.28 99.82
173 INT1045 Localization of LH 1211 0.81 87.04 456.25 99.80
174 INT789 Positive_regulation of YY1 69 0.67 14.07 47.06 99.80
175 INT2379 Positive_regulation of Localization of LH 349 0.70 27.86 144.53 99.80
176 INT7465 Negative_regulation of Mbp 53 0.58 19.12 13.27 99.80
177 INT66381 Regulation of Prkaca 40 0.62 13.38 27.96 99.80
178 INT158 Localization of Prl 2431 0.81 378.96 952.2 99.78
179 INT767 Localization of Gnrhr 565 0.80 106.68 214.57 99.78
180 INT11336 Gene_expression of Ptgfr 23 0.78 2.88 9.07 99.78
181 INT1335 Negative_regulation of Oprl1 123 0.59 18.02 77.13 99.78
182 INT58215 Regulation of Asprv1 2 0.40 0.41 0.77 99.78
183 INT96741 Gene_expression of Cxcr4 62 0.78 32.3 22.14 99.76
184 INT10806 Positive_regulation of Transcription of Pomc 13 0.50 1.74 4.58 99.76
185 INT239556 Positive_regulation of Phosphorylation of CXCR2 1 0.18 0.11 0.53 99.74
186 INT239553 Positive_regulation of Phosphorylation of CXCR1 1 0.50 0.11 0.53 99.74
187 INT77353 Transcription of Gnai1 1 0.65 0 0.84 99.74
188 INT5597 Gene_expression of Pdyn 433 0.78 62.97 235.47 99.72
189 INT72011 Positive_regulation of Binding of Ptprg 42 0.50 2.72 39.89 99.72
190 INT53798 Gene_expression of Oprk1 14 0.73 1.82 8.24 99.72
191 INT48202 Gene_expression of Tgfb1 146 0.78 89.93 27.76 99.72
192 INT48718 Positive_regulation of PRKCA 109 0.69 36.16 46.49 99.72
193 INT55878 Regulation of Gene_expression of CCL2 34 0.62 15.71 17.97 99.72
194 INT89845 Positive_regulation of Src 19 0.44 7.5 9.01 99.72
195 INT19110 Gene_expression of Odc1 19 0.78 4.51 6.11 99.72
196 INT89844 Positive_regulation of Phosphorylation of Src 10 0.43 4.71 4.95 99.72
197 INT122715 Negative_regulation of Localization of Esrra 1 0.02 0 1.68 99.68
198 INT1579 Gene_expression of PRL 279 0.78 119.2 55.41 99.68
199 INT113122 Regulation of Binding of Gpm6a 2 0.11 0 0.91 99.68
200 INT21185 Binding of Ptprg 213 0.47 13.49 157.75 99.66
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