P:Mexiletine

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pChart

Pain Term
Category Drug
Synonyms None
Pain Specific No
Documents 405
Hot Single Events 94
Hot Interactions 1

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported for Mexiletine. They are ordered first by their pain relevance and then by number of times they were reported for Mexiletine. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT131949 ANTXR1 Positive_regulation of NAV1 1 0.03 0.23 1.38 89.04
2 INT111244 Binding of BRS3 and SCN5A 1 0.00 0.72 0.48 54.08
3 INT351427 Binding of PIK3C3 and RYR1 1 0.00 0 0.11 43.60
4 INT212301 NGF Regulation of Gene_expression of TRPV1 1 0.23 2.37 2.13 5.00
5 INT314986 Ins1 Negative_regulation of CACNA1S 1 0.00 0.08 0 5.00
6 INT265264 Binding of NA and SCN5A 1 0.03 0.55 0 5.00
7 INT265265 SCN5A Regulation of Gene_expression of NAV1 1 0.01 0.16 0 5.00

Single Events

The table below shows the top 200 pain related interactions that have been reported for Mexiletine. They are ordered first by their pain relevance and then by number of times they were reported in Mexiletine. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT50404 Negative_regulation of CYP1A2 49 0.59 8.61 17.35 100.00
2 INT68899 Binding of CYP1A2 19 0.48 2.33 5.73 100.00
3 INT67468 Regulation of SCN5A 27 0.44 4.4 3.47 100.00
4 INT160733 Regulation of Hcn4 1 0.50 0.12 0.28 100.00
5 INT118219 Negative_regulation of Binding of OR51B4 1 0.36 0 0.71 99.98
6 INT11996 Gene_expression of Ina 34 0.67 4.8 13.82 99.98
7 INT101738 Regulation of CACNA1E 1 0.04 0 0.49 99.98
8 INT165 Regulation of HRH1 12 0.45 1.76 7.57 99.98
9 INT9556 Negative_regulation of NAV1 47 0.59 28.49 49.33 99.92
10 INT216250 Gene_expression of ZNF492 1 0.08 0.98 0.88 99.92
11 INT216252 Positive_regulation of Gene_expression of ZNF492 1 0.06 0.08 0.29 99.92
12 INT24871 Negative_regulation of Binding of IGHE 10 0.58 2.87 2.64 99.92
13 INT6097 Negative_regulation of NEUROD1 30 0.57 9.71 6.24 99.86
14 INT118220 Negative_regulation of OR51B4 3 0.27 0.46 1.13 99.86
15 INT298 Negative_regulation of ADRB3 23 0.59 6.82 7.56 99.86
16 INT6098 Binding of NEUROD1 17 0.47 3.4 5.99 99.76
17 INT4104 Gene_expression of ADRB3 19 0.78 2.68 4.12 99.76
18 INT77600 Binding of OR51B4 4 0.30 0.8 1.38 99.76
19 INT109 Binding of ADRB3 17 0.47 3.02 3.84 99.76
20 INT43482 Regulation of Binding of ADRB3 4 0.60 1.06 1.54 99.76
21 INT5536 Regulation of NA 74 0.59 16.61 15.36 99.72
22 INT3392 Negative_regulation of Sst 23 0.59 8.21 15.82 99.72
23 INT2435 Negative_regulation of Cyp1a1 15 0.58 3.32 5.16 99.56
24 INT203 Positive_regulation of Pomc 257 0.70 90.56 92.84 99.48
25 INT8775 Binding of IGHE 167 0.48 102.61 23.54 99.36
26 INT46691 Negative_regulation of SCN9A 5 0.50 1.37 3.44 99.30
27 INT83674 Negative_regulation of SCN10A 14 0.59 7.28 9.65 99.30
28 INT4148 Gene_expression of HRH1 11 0.77 2.71 4.22 99.18
29 INT22000 Positive_regulation of Sst 25 0.70 14.82 13.6 99.06
30 INT12924 Negative_regulation of Gene_expression of NA 25 0.30 6.59 6.71 98.98
31 INT101739 Gene_expression of CACNA1E 2 0.25 0.43 0.49 98.86
32 INT23886 Positive_regulation of Gene_expression of NA 15 0.40 3.69 3.59 98.78
33 INT6277 Positive_regulation of Gene_expression of Pomc 76 0.70 21.45 31.09 98.74
34 INT200438 Negative_regulation of Gene_expression of SCN5A 6 0.36 1.93 0.71 98.68
35 INT160786 Regulation of Tada1 1 0.16 0.69 1.04 98.64
36 INT6623 Gene_expression of NA 231 0.78 45.78 59.36 98.60
37 INT29832 Negative_regulation of Scn7a 20 0.37 5.91 3.63 98.52
38 INT1536 Negative_regulation of NA 244 0.55 52.67 59.79 98.46
39 INT77601 Gene_expression of OR51B4 15 0.58 2.07 6.19 98.44
40 INT13409 Gene_expression of NEUROD1 52 0.75 14.17 12.23 98.44
41 INT2640 Gene_expression of Pomc 424 0.78 120.72 155.37 98.44
42 INT152 Negative_regulation of MBD2 31 0.38 3.95 11.31 98.24
43 INT6782 Gene_expression of SCN5A 156 0.78 33.13 17.88 98.00
44 INT51735 Negative_regulation of Regulation of MUC7 1 0.06 0.39 0.69 97.96
45 INT131950 Negative_regulation of Positive_regulation of NAV1 2 0.31 0.22 1.99 97.68
46 INT1433 Regulation of MUC7 21 0.60 1.7 8.18 97.66
47 INT78749 Gene_expression of SCN10A 25 0.75 9.23 16.5 97.64
48 INT113490 Gene_expression of SCN9A 22 0.77 5.45 12.27 97.64
49 INT64076 Positive_regulation of Kcnma1 47 0.40 11.52 24.19 97.60
50 INT163321 Protein_catabolism of SCN5A 1 0.64 0.25 0.31 97.60
51 INT12346 Binding of Scn8a 5 0.29 0.75 1.64 97.56
52 INT98323 Regulation of Mtfp1 1 0.14 0.19 0.4 97.48
53 INT38144 Positive_regulation of HRH1 7 0.57 2.57 2.51 97.20
54 INT129303 Positive_regulation of NAV1 54 0.70 36.92 57.45 97.00
55 INT31742 Negative_regulation of RPL7AP7 3 0.54 1.19 3.07 96.92
56 INT51734 Negative_regulation of Localization of Trib3 10 0.19 2.53 4.97 96.52
57 INT136268 Localization of NAV1 22 0.75 2.84 26.23 96.32
58 INT22210 Gene_expression of CYP1A2 45 0.78 4.95 10.66 96.16
59 INT38253 Localization of Trib3 35 0.63 10.28 15.42 96.14
60 INT97367 Gene_expression of Nav1 243 0.78 132.97 286.66 96.08
61 INT216249 Positive_regulation of ZNF492 1 0.05 0 0.24 94.96
62 INT34425 Positive_regulation of Negative_regulation of NA 12 0.38 4.17 3.2 94.72
63 INT25221 Negative_regulation of FAS-AS1 1 0.42 0.43 1.08 94.20
64 INT56098 Gene_expression of HLA-DRB3 5 0.59 2.89 0.99 93.76
65 INT130494 Gene_expression of CCBP2 2 0.65 1.41 1.43 93.44
66 INT52689 Regulation of Ptgs2 27 0.60 12.76 10.6 93.12
67 INT64201 Negative_regulation of Trpv1 203 0.59 79.18 119.75 93.04
68 INT114568 Negative_regulation of Trpc1 4 0.41 0.56 1.19 93.04
69 INT117369 Gene_expression of SLC22A3 3 0.59 0.22 0.7 92.56
70 INT7743 Binding of Hrh2 19 0.47 7.75 7.11 92.52
71 INT189813 Negative_regulation of CACNA1A 4 0.57 3.07 0.55 92.32
72 INT30209 Localization of SCN5A 24 0.72 7.95 5.35 92.28
73 INT86646 Positive_regulation of SCN10A 71 0.69 50.61 13.24 91.76
74 INT6791 Binding of NA 55 0.46 5.36 17.59 91.68
75 INT216253 Regulation of ZNF492 1 0.03 0.13 0.28 91.56
76 INT19409 Binding of Cyp1a1 12 0.48 2.58 1.97 89.64
77 INT38254 Positive_regulation of Localization of Trib3 14 0.45 6.14 6.99 89.12
78 INT4449 Positive_regulation of NA 179 0.55 40.26 37.82 88.40
79 INT1033 Positive_regulation of Ca2 507 0.68 131.76 147.64 88.40
80 INT46460 Gene_expression of NAV1 288 0.78 135.51 305.75 88.24
81 INT10795 Positive_regulation of CD59 9 0.36 2.11 2.52 87.12
82 INT107576 Gene_expression of Atf3 114 0.78 72.42 38.64 86.40
83 INT129158 Gene_expression of Sf3a3 5 0.13 6.47 3.67 86.40
84 INT129159 Positive_regulation of Gene_expression of Sf3a3 2 0.10 1.89 1.21 86.40
85 INT129157 Positive_regulation of Atf3 48 0.69 35.42 22.87 86.00
86 INT129156 Positive_regulation of Sf3a3 9 0.08 10.89 7.01 86.00
87 INT230717 Positive_regulation of Negative_regulation of NAV1 1 0.42 0.48 0.73 85.64
88 INT91913 Regulation of GRIN3B 16 0.61 11.48 14.44 85.36
89 INT2897 Positive_regulation of Thra 20 0.45 5.17 3.01 84.08
90 INT45980 Positive_regulation of Vent1 1 0.00 0.84 0.12 84.08
91 INT216251 Regulation of Gene_expression of ZNF492 1 0.05 0 0.18 83.16
92 INT36622 Positive_regulation of Reb1 1 0.00 0.78 0.16 82.36
93 INT19366 Negative_regulation of Localization of Ca2 33 0.50 6.51 6.61 81.36
94 INT86602 Binding of KCNH2 14 0.36 4.65 2.58 80.48
95 INT23598 Binding of SCN5A 32 0.40 16 5.35 78.96
96 INT5743 Localization of NA 104 0.59 14.35 35.29 78.64
97 INT15026 Negative_regulation of Localization of NA 26 0.36 3.76 10.69 78.64
98 INT138639 Gene_expression of Hcn4 32 0.75 13.85 11.25 78.48
99 INT4822 Localization of Ca2 417 0.80 99.57 96.45 78.28
100 INT64280 Positive_regulation of Ptger1 22 0.67 14.9 7.49 78.00
101 INT100743 Regulation of KCNH2 6 0.54 2.37 2.61 77.24
102 INT103518 Negative_regulation of SCN2A 17 0.57 8.4 5.4 76.96
103 INT152178 Positive_regulation of Negative_regulation of SCN2A 1 0.49 0.16 0.61 76.96
104 INT39632 Regulation of Localization of NA 8 0.20 1.52 1.81 75.60
105 INT73323 Negative_regulation of Scn10a 13 0.58 5.77 7.85 74.96
106 INT152177 Positive_regulation of Negative_regulation of Scn10a 1 0.43 0.16 0.6 74.96
107 INT216248 Negative_regulation of Gene_expression of KCNQ1 1 0.38 0.33 0.14 72.88
108 INT3589 Positive_regulation of SCN5A 101 0.57 46.01 21.73 72.32
109 INT136266 Gene_expression of KCNQ1 23 0.64 8.34 3.11 72.32
110 INT95995 Positive_regulation of KCNQ3 2 0.67 0.79 0.19 72.32
111 INT116226 Regulation of NAV1 20 0.51 14.32 25.61 71.76
112 INT160134 Regulation of Hcn1 2 0.38 0.54 0.7 70.64
113 INT107575 Positive_regulation of Gene_expression of Atf3 25 0.69 27.37 14.55 69.12
114 INT9132 Negative_regulation of Prkcg 279 0.59 88.05 203.47 68.20
115 INT115909 Positive_regulation of Gene_expression of Nav1 25 0.70 16.58 27.63 67.68
116 INT210571 Gene_expression of KCNE2 7 0.61 2.7 0.97 66.96
117 INT105021 Binding of GOPC 187 0.40 60.39 20.38 66.84
118 INT230716 Regulation of Binding of GOPC 2 0.10 0.26 1.59 66.84
119 INT15027 Positive_regulation of Localization of NA 11 0.26 3.4 2.98 65.88
120 INT166132 Positive_regulation of Dhrs4 2 0.54 1.95 0.65 65.04
121 INT13752 Binding of Scn4a 24 0.36 5.68 14.16 64.32
122 INT100965 Positive_regulation of Nav1 85 0.70 37.74 75.35 63.72
123 INT170601 Positive_regulation of Gene_expression of GOPC 122 0.43 42.79 11.68 62.80
124 INT52589 Positive_regulation of Gene_expression of SCN5A 14 0.49 3.84 1.33 62.80
125 INT90091 Gene_expression of GOPC 967 0.67 366.22 103.6 62.20
126 INT102429 Negative_regulation of Gene_expression of Nav1 19 0.59 20.09 28.09 60.88
127 INT48248 Gene_expression of Scn10a 38 0.78 19.3 25.05 60.16
128 INT4577 Negative_regulation of Thra 24 0.56 3.75 4.73 58.84
129 INT205596 Negative_regulation of COQ10A 22 0.51 15.61 2.77 56.00
130 INT111247 Binding of BRS3 1 0.02 0.72 0.48 54.08
131 INT8634 Gene_expression of Nfasc 23 0.68 9.16 14.96 51.92
132 INT130793 Positive_regulation of Gene_expression of Nfasc 1 0.02 1.76 0.99 51.92
133 INT123419 Binding of NAV1 37 0.48 7.09 26.43 51.88
134 INT6108 Gene_expression of Npy 292 0.78 110.65 148.21 49.28
135 INT8380 Positive_regulation of Gene_expression of Npy 49 0.70 19.62 24.13 49.28
136 INT3375 Gene_expression of IGHE 535 0.77 387.47 65.46 45.92
137 INT131413 Positive_regulation of Gene_expression of NAV1 35 0.70 17.5 36.83 44.24
138 INT59555 Binding of RYR1 39 0.42 8.65 4.92 43.60
139 INT351430 Binding of PIK3C3 1 0.01 0 0.11 43.60
140 INT253030 Binding of HPP1 1 0.03 1.43 0.04 42.56
141 INT26273 Negative_regulation of RYR1 18 0.43 7.64 3.11 41.68
142 INT55224 Gene_expression of DRGX 99 0.31 67.55 67.63 37.52
143 INT51946 Gene_expression of Apold1 13 0.39 3.56 6.08 37.52
144 INT193622 Positive_regulation of ICA1L 1 0.07 1.51 0.14 33.76
145 INT28164 Regulation of ALOX5 25 0.60 12.76 5.47 30.44
146 INT30887 Negative_regulation of Ngf 56 0.59 32.96 20.86 25.00
147 INT16255 Negative_regulation of Ntf3 21 0.51 12.92 11.93 25.00
148 INT62992 Regulation of COLQ 1 0.26 0.6 0.3 25.00
149 INT6906 Negative_regulation of SCN5A 64 0.43 20.64 7.3 19.28
150 INT18357 Gene_expression of TRPV1 825 0.78 307.11 382.81 14.32
151 INT58060 Negative_regulation of HMI 30 0.44 11.9 5.06 10.84
152 INT9381 Positive_regulation of TRPV1 523 0.70 187.4 276.05 10.64
153 INT9987 Gene_expression of Abat 296 0.78 95.46 226.34 5.00
154 INT626 Localization of CALCA 289 0.81 125.39 221.15 5.00
155 INT2211 Negative_regulation of Abat 267 0.59 66.51 200.98 5.00
156 INT2910 Regulation of Abat 169 0.62 36.95 153.53 5.00
157 INT812 Localization of INS 1026 0.81 515.6 145.31 5.00
158 INT170025 Gene_expression of Fig4 588 0.67 183.27 113.32 5.00
159 INT12476 Negative_regulation of TRPV1 124 0.59 47.95 77.98 5.00
160 INT62374 Gene_expression of NGF 158 0.78 77.87 76.45 5.00
161 INT17401 Gene_expression of IGF1 475 0.78 232.18 62.07 5.00
162 INT97368 Negative_regulation of Nav1 62 0.59 41.56 60.27 5.00
163 INT74389 Gene_expression of Gdnf 131 0.78 58.52 57.06 5.00
164 INT9383 Localization of TRPV1 98 0.81 33.23 46.24 5.00
165 INT1322 Positive_regulation of Localization of INS 293 0.70 120.86 45.98 5.00
166 INT42980 Gene_expression of GAD1 139 0.69 94.77 45.11 5.00
167 INT27493 Negative_regulation of Casp3 114 0.56 56.89 44.63 5.00
168 INT69437 Positive_regulation of ROS1 328 0.58 222.83 40.56 5.00
169 INT2274 Regulation of Localization of INS 101 0.62 41.55 34.79 5.00
170 INT5653 Positive_regulation of ELANE 136 0.70 72.78 27.94 5.00
171 INT8580 Gene_expression of ELANE 132 0.75 62.98 21.79 5.00
172 INT31874 Negative_regulation of Gene_expression of Abat 31 0.42 12.22 20.31 5.00
173 INT17442 Gene_expression of ALOX5 110 0.75 51.55 18.29 5.00
174 INT145971 Localization of Nav1 20 0.81 10.3 18.11 5.00
175 INT133647 Negative_regulation of HDAC9 149 0.57 106.84 17.9 5.00
176 INT3364 Binding of SGCG 87 0.47 31.93 17.24 5.00
177 INT114507 Negative_regulation of Gene_expression of NAV1 17 0.43 7.24 15.93 5.00
178 INT170855 Negative_regulation of GOPC 188 0.38 70.92 15.41 5.00
179 INT71634 Gene_expression of SLC6A3 45 0.78 13.48 15.23 5.00
180 INT65697 Positive_regulation of GRIN3B 23 0.69 12.52 13.78 5.00
181 INT69435 Negative_regulation of ROS1 74 0.51 50.38 13.71 5.00
182 INT99116 Binding of Cacna2d3 15 0.48 7.33 13.58 5.00
183 INT49975 Binding of SLC6A3 34 0.47 9.86 12.41 5.00
184 INT49212 Negative_regulation of GAD1 23 0.59 22.15 6.54 5.00
185 INT123787 Gene_expression of Bid 25 0.66 16 6.35 5.00
186 INT57232 Binding of Casp3 22 0.36 9.42 6.2 5.00
187 INT86600 Gene_expression of KCNH2 37 0.78 14.88 6.14 5.00
188 INT28165 Positive_regulation of ALOX5 38 0.47 10.8 5.37 5.00
189 INT10100 Binding of ELANE 22 0.47 15.32 5.19 5.00
190 INT51030 Negative_regulation of LMOD1 9 0.44 5.83 4.58 5.00
191 INT36309 Negative_regulation of DIO2 18 0.57 6.42 4.51 5.00
192 INT3405 Gene_expression of BCAR1 14 0.71 8.89 4.02 5.00
193 INT3403 Positive_regulation of BCAR1 18 0.63 18.95 3.23 5.00
194 INT10476 Binding of ALOX5 26 0.36 7.69 3.2 5.00
195 INT25674 Positive_regulation of Gene_expression of ELANE 16 0.60 7.46 3.12 5.00
196 INT45971 Negative_regulation of GOT1 9 0.51 6.2 2.84 5.00
197 INT149314 Negative_regulation of CAV2 5 0.42 1.21 2.76 5.00
198 INT155227 Gene_expression of Kcne1 7 0.19 1.72 2.72 5.00
199 INT123795 Positive_regulation of KCNQ1 13 0.49 3.53 2.65 5.00
200 INT205594 Gene_expression of COQ10A 19 0.67 12.53 2.56 5.00
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