P:Myofascial pain syndrome

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Pain Term
Category Disorder
Synonyms Myofascial Pain Syndromes, Myofascial Trigger Point, Myofascial Trigger Points, Pain Syndrome Myofascial, Pain Syndromes Myofascial, Syndrome Myofascial Pain, Syndromes Myofascial Pain, Temporomandibular Disorders, Trigger Point Myofascial, Trigger Points Myofascial
Pain Specific Yes
Documents 2313
Hot Single Events 109
Hot Interactions 2

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported for Myofascial pain syndrome. They are ordered first by their pain relevance and then by number of times they were reported for Myofascial pain syndrome. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT83395 Binding of IL1RN and Tgfb1 1 0.01 0.17 0.26 97.40
2 INT169557 Cacna1h Positive_regulation of Mapk1 1 0.07 0.91 1.17 93.56
3 INT351323 Nts Regulation of Localization of Calca 1 0.01 0.6 0.85 66.32
4 INT351322 Nts Regulation of Localization of Napa 1 0.01 0.56 0.77 60.40
5 INT262377 Binding of Comt and Fmod 1 0.06 1.47 1.29 46.32
6 INT298456 Prkaca Positive_regulation of Phosphorylation of Adarb1 1 0.00 1.86 2.85 45.68
7 INT97208 Binding of Gabrg1 and Gabbr1 2 0.07 0.31 1.94 5.00
8 INT298458 Binding of Calcrl and Adarb1 1 0.00 0.23 1.41 5.00
9 INT298455 Calca Positive_regulation of Gene_expression of Ceacam3 1 0.17 0.47 1.34 5.00
10 INT298454 Prkcg Positive_regulation of Phosphorylation of Adarb1 1 0.00 0.41 1.19 5.00
11 INT222516 Binding of Calcrl and Ramp1 5 0.17 0.11 1.12 5.00
12 INT346986 Binding of SHC3 and PAG1 1 0.35 1.02 1.12 5.00
13 INT206857 Binding of Calca and Calcrl 4 0.37 1.9 0.95 5.00
14 INT113542 Binding of Calca and Adarb1 2 0.00 0.44 0.85 5.00
15 INT298457 Binding of Calca and Npr1 1 0.01 0.39 0.77 5.00
16 INT252869 Binding of Trpv1 and Phax 2 0.01 0.18 0.6 5.00
17 INT298462 Calca Regulation of PPR 1 0.03 0 0.54 5.00
18 INT354235 Aif1 Regulation of P2ry12 1 0.20 0.49 0.45 5.00
19 INT204943 Il6 Regulation of Slc39a14 1 0.00 0.54 0.36 5.00
20 INT195423 COMT Negative_regulation of GBE1 1 0.00 0.22 0.19 5.00
21 INT195424 SNRNP70 Negative_regulation of GBE1 1 0.00 0.22 0.19 5.00
22 INT122216 IL1B Positive_regulation of CCL5 3 0.67 0.53 0.04 5.00
23 INT122217 IL1B Positive_regulation of Gene_expression of CCL5 2 0.52 0.08 0 5.00

Single Events

The table below shows the top 200 pain related interactions that have been reported for Myofascial pain syndrome. They are ordered first by their pain relevance and then by number of times they were reported in Myofascial pain syndrome. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT21687 Positive_regulation of ras 143 0.58 97.34 27.31 100.00
2 INT19396 Regulation of Rac1 66 0.53 37.41 30.01 100.00
3 INT57957 Localization of TXNRD1 14 0.64 4.01 2.7 100.00
4 INT39507 Positive_regulation of TXNRD1 37 0.68 12.47 14.25 100.00
5 INT47540 Binding of Cp 20 0.41 15.54 7.01 100.00
6 INT69951 Binding of Cgnz1 3 0.25 1.82 1.64 100.00
7 INT137961 Localization of Ppt1 1 0.64 2.89 3.09 99.52
8 INT158279 Regulation of Myst2 2 0.37 0.51 0.65 99.48
9 INT2543 Positive_regulation of Calca 787 0.70 331.13 592.08 99.46
10 INT47909 Binding of CPP 32 0.48 24.9 13.79 99.38
11 INT86437 Binding of IL6 154 0.48 121.22 29.3 99.32
12 INT62784 Gene_expression of NT5E 46 0.65 15.95 3.72 99.30
13 INT96419 Positive_regulation of Gene_expression of NT5E 3 0.49 1.46 0.41 99.30
14 INT123843 Gene_expression of soc 14 0.58 5.22 1.96 99.26
15 INT135629 Binding of COMT 33 0.48 16.68 19.37 99.04
16 INT64202 Positive_regulation of Trpv1 643 0.70 249.66 397.42 99.00
17 INT10194 Positive_regulation of IL6 702 0.70 600.62 183.38 98.96
18 INT9238 Gene_expression of IL6 1575 0.78 1135.66 424.22 98.72
19 INT11161 Gene_expression of HLA-DRB1 121 0.78 75.33 20.96 98.72
20 INT9659 Gene_expression of Il6 991 0.78 715.11 265.57 98.72
21 INT71350 Positive_regulation of Tpnr1 3 0.01 3.92 4.08 98.68
22 INT96420 Positive_regulation of NT5E 9 0.49 3.7 1.38 98.64
23 INT138254 Regulation of Positive_regulation of Laptm4a 1 0.15 0.46 0.46 98.60
24 INT138253 Positive_regulation of Laptm4a 1 0.23 0.46 0.46 98.60
25 INT48955 Gene_expression of Nos2 753 0.78 403.87 208.08 98.20
26 INT69681 Negative_regulation of Tgfb1 42 0.51 22.28 4 98.16
27 INT14700 Regulation of IFNA1 111 0.45 66.16 21.52 98.08
28 INT4652 Gene_expression of CB 13 0.32 7.41 5.57 98.08
29 INT739 Negative_regulation of POMC 358 0.59 102.28 166.77 98.08
30 INT48953 Positive_regulation of Nos2 486 0.70 239.85 131.87 97.92
31 INT129608 Gene_expression of Adamts4 8 0.77 1.11 0.68 97.88
32 INT69440 Gene_expression of ROS1 752 0.78 477.64 103.83 97.72
33 INT58258 Regulation of sea 5 0.39 0.63 0.6 97.64
34 INT109133 Gene_expression of VCAN 52 0.75 53.11 0.84 97.36
35 INT90766 Gene_expression of PCS 93 0.77 40.48 14.51 96.76
36 INT157962 Positive_regulation of LAPTM4A 1 0.33 1.03 0.79 96.68
37 INT70619 Regulation of Bmp2 6 0.60 3.1 1.29 96.68
38 INT9643 Negative_regulation of Actvty1 7 0.07 5.54 3.31 96.68
39 INT145301 Regulation of Gene_expression of Bmp2 1 0.32 1.16 0.48 96.68
40 INT145304 Regulation of Gene_expression of Sox9 1 0.43 1.04 0.46 96.68
41 INT9660 Regulation of TNF 363 0.62 312.94 139.99 96.68
42 INT5374 Gene_expression of Esr1 412 0.77 263.89 67.34 96.56
43 INT5200 Gene_expression of Fos 3083 0.78 894.43 1639.02 96.28
44 INT6056 Negative_regulation of Gene_expression of Fos 601 0.59 193.05 386.84 96.28
45 INT20102 Gene_expression of Serpine1 102 0.78 65.99 12.61 96.24
46 INT262375 Binding of Fmod 1 0.20 12.37 10.1 96.24
47 INT81485 Negative_regulation of IL1RN 19 0.57 8.3 4.69 96.00
48 INT121525 Binding of Ids 1 0.31 0.1 0.1 95.76
49 INT1316 Positive_regulation of Acot1 129 0.60 18.86 56.13 95.64
50 INT9210 Regulation of IL6 166 0.62 125.61 49.95 95.52
51 INT7341 Positive_regulation of Grin1 169 0.70 65.86 118.38 95.52
52 INT88650 Negative_regulation of Prkce 13 0.57 11.93 11.16 95.52
53 INT19078 Binding of Ngf 78 0.48 31.03 44.33 95.36
54 INT71150 Binding of NGF 22 0.46 13.67 14.81 95.36
55 INT22632 Positive_regulation of HDC 2 0.69 2.28 1.75 95.32
56 INT3766 Positive_regulation of Localization of Acot1 192 0.69 21.8 85.35 95.28
57 INT1352 Localization of Acot1 728 0.80 73.01 296.01 95.28
58 INT41727 Negative_regulation of Localization of Nts 3 0.39 1.48 3.15 95.22
59 INT7458 Negative_regulation of Kcnma1 30 0.43 6.61 10.4 95.16
60 INT177992 Positive_regulation of SNRNP70 28 0.49 16.14 4.28 94.64
61 INT15044 Localization of Nts 30 0.75 4.58 13.72 94.60
62 INT52916 Negative_regulation of Prkca 9 0.54 2.4 10.79 94.60
63 INT169180 Binding of SNRNP70 204 0.47 119.1 29.3 94.20
64 INT96423 Gene_expression of Bmp2 61 0.78 25.07 3.01 94.08
65 INT145306 Gene_expression of Sox9 5 0.54 2.47 0.8 94.08
66 INT89516 Negative_regulation of Grm8 7 0.41 4.01 3.82 94.00
67 INT2330 Regulation of CB 78 0.10 20.46 32.6 93.84
68 INT5202 Positive_regulation of Gene_expression of Fos 1163 0.70 319.28 684 93.64
69 INT95787 Positive_regulation of Mapk1 568 0.70 226.51 220.94 93.56
70 INT108535 Positive_regulation of TNNI1 7 0.67 5.54 2.12 93.44
71 INT48120 Positive_regulation of Cacna1h 5 0.34 1.2 2.22 93.28
72 INT145303 Regulation of Sox9 2 0.28 0.71 0.22 92.28
73 INT256655 Positive_regulation of Psma1 1 0.20 0.8 1.45 92.08
74 INT1080 Negative_regulation of Ache 343 0.59 108.51 72.4 92.04
75 INT5972 Gene_expression of IL1B 948 0.78 510.91 263.97 91.68
76 INT16868 Gene_expression of Il6 807 0.78 499.48 256.57 91.68
77 INT10832 Gene_expression of IL8 1050 0.78 698.72 270 91.68
78 INT109134 Gene_expression of PRG3 1 0.42 0.29 0.29 91.68
79 INT78899 Gene_expression of CCL5 155 0.77 84.02 55.09 91.64
80 INT47459 Gene_expression of Rac1 101 0.68 45.27 24.33 91.60
81 INT106422 Negative_regulation of Gene_expression of Rac1 4 0.43 3.97 3.41 91.60
82 INT24196 Positive_regulation of Binding of Chrna7 8 0.45 0.79 2.13 91.28
83 INT3362 Negative_regulation of Emg1 21 0.57 10.03 15.93 91.20
84 INT61452 Gene_expression of IL1RAP 15 0.58 7.21 5.09 90.92
85 INT134346 Binding of PCS 51 0.37 22.27 5.67 90.84
86 INT626 Localization of CALCA 289 0.81 125.39 221.15 90.40
87 INT166490 Localization of Msn 9 0.80 0.61 2.32 89.96
88 INT77955 Negative_regulation of PCS 55 0.43 39.32 5.76 89.60
89 INT7134 Localization of KNG1 127 0.79 65.73 67.97 88.32
90 INT89048 Gene_expression of P2RX2 28 0.75 8.75 7.9 88.24
91 INT33857 Negative_regulation of NTS 6 0.42 4.98 3.07 87.84
92 INT23330 Binding of Chrna7 79 0.48 10.06 35.5 87.28
93 INT93738 Gene_expression of Tnfrsf1a 63 0.74 57.66 23.09 87.08
94 INT64076 Positive_regulation of Kcnma1 47 0.40 11.52 24.19 87.00
95 INT95989 Positive_regulation of Kcnq2 9 0.68 2.58 4.75 86.48
96 INT120365 Positive_regulation of KCNQ2 3 0.67 1.13 1.58 86.48
97 INT23212 Positive_regulation of Rac1 46 0.55 32.85 15.1 86.40
98 INT7898 Gene_expression of Homer1 123 0.78 31.52 53.67 86.32
99 INT355176 Regulation of Binding of TTN 1 0.29 0.78 0.09 85.12
100 INT148080 Binding of Ots1 1 0.28 0.74 0.56 85.04
101 INT76227 Binding of NPC1 30 0.41 32.31 4.05 84.48
102 INT307700 Regulation of HOPX 4 0.53 7.64 3.5 84.32
103 INT89519 Negative_regulation of COL1A2 10 0.36 6.26 2.17 83.84
104 INT58061 Gene_expression of Trpv1 1117 0.78 451.54 637.59 83.80
105 INT127981 Gene_expression of Trpc1 25 0.77 10.51 11.67 83.52
106 INT37296 Binding of Esr1 117 0.43 62.51 27.33 82.88
107 INT105783 Protein_catabolism of IL6 7 0.48 4.72 2.95 82.72
108 INT44246 Positive_regulation of Sts 9 0.43 6.19 0.45 81.68
109 INT137702 Binding of TTN 7 0.35 4.48 3.62 81.28
110 INT104031 Regulation of ENPEP 18 0.33 13.48 1.69 79.72
111 INT23246 Gene_expression of HLA-DRB4 37 0.64 36.79 6.61 79.68
112 INT17237 Regulation of Esr1 74 0.43 49.09 17.25 79.12
113 INT11937 Localization of Il6 228 0.81 139.83 64.39 78.16
114 INT767 Localization of Gnrhr 565 0.80 106.68 214.57 78.16
115 INT3559 Negative_regulation of Localization of Gnrhr 73 0.58 18.89 26.41 78.16
116 INT158278 Positive_regulation of Myst2 2 0.41 0.89 1.02 77.92
117 INT178282 Localization of SEMG1 3 0.65 1.08 0.14 76.80
118 INT188449 Gene_expression of ENPEP 12 0.55 11.29 3.96 76.76
119 INT9131 Positive_regulation of Prkcg 431 0.70 130.8 302.41 76.72
120 INT2391 Negative_regulation of PTGS1 501 0.59 207.62 205.6 75.44
121 INT34869 Negative_regulation of PTGS2 778 0.59 366.76 319.85 75.44
122 INT5774 Regulation of Ppt1 22 0.60 4.97 7.1 75.00
123 INT5333 Gene_expression of NPEPPS 45 0.65 26.34 15.25 75.00
124 INT108306 Positive_regulation of TNFRSF11B 28 0.60 12.74 4.46 75.00
125 INT113282 Negative_regulation of TNFRSF11B 17 0.57 13.71 4.17 75.00
126 INT113281 Binding of TNFRSF11B 9 0.47 2.97 1.78 75.00
127 INT1912 Gene_expression of Calca 1152 0.78 453.25 739.84 75.00
128 INT165258 Binding of BC013712 1 0.06 0.85 1.02 75.00
129 INT4729 Positive_regulation of PPT1 19 0.67 7.11 17.83 75.00
130 INT107119 Positive_regulation of Idh1 1 0.36 0.42 0.63 75.00
131 INT14575 Positive_regulation of Ppt1 60 0.70 9.97 27.4 75.00
132 INT55353 Negative_regulation of Positive_regulation of Ppt1 9 0.57 0.31 5.37 75.00
133 INT155 Positive_regulation of Prl 1233 0.70 317.93 457.82 75.00
134 INT528 Gene_expression of Prl 693 0.78 217.18 192.2 75.00
135 INT6108 Gene_expression of Npy 292 0.78 110.65 148.21 75.00
136 INT2541 Binding of Calca 200 0.48 67.14 134.62 75.00
137 INT5283 Positive_regulation of Npy 191 0.70 66.77 109.2 75.00
138 INT6477 Gene_expression of IL1RN 213 0.77 114.69 58.62 75.00
139 INT12424 Binding of Npy 48 0.48 8.23 24.26 75.00
140 INT19399 Gene_expression of Rf 43 0.36 33.39 13.53 75.00
141 INT24741 Positive_regulation of Rf 16 0.17 18.23 4.75 75.00
142 INT5332 Negative_regulation of Gene_expression of NPEPPS 11 0.04 7.79 4.29 75.00
143 INT5331 Positive_regulation of Gene_expression of NPEPPS 6 0.49 3.74 1.81 75.00
144 INT33400 Regulation of CDS1 8 0.29 5.12 1.79 75.00
145 INT59786 Binding of SERPINE2 4 0.32 2.98 0.79 75.00
146 INT92116 Binding of TUFM 1 0.36 1.42 0.31 75.00
147 INT8243 Positive_regulation of Il6 451 0.70 358.24 119.28 74.96
148 INT252576 Binding of Emg1 1 0.32 0.77 0.56 74.56
149 INT141236 Binding of DNLZ 1 0.37 1.02 1.09 74.40
150 INT62336 Positive_regulation of Hdc 38 0.70 14.45 5.51 73.84
151 INT92966 Positive_regulation of FGF1 4 0.38 2.25 1.33 73.12
152 INT20937 Regulation of MGP 4 0.43 0.62 1.37 71.68
153 INT2649 Regulation of Calca 433 0.62 146.05 330.95 71.60
154 INT355175 Gene_expression of HOPX 1 0.58 1.67 1.01 70.80
155 INT85054 Regulation of SMU1 2 0.24 0.17 0.32 69.76
156 INT89054 Positive_regulation of Gene_expression of Trpv1 156 0.70 90.78 102.03 69.48
157 INT3439 Localization of Abat 1017 0.78 112.39 727.06 69.32
158 INT3441 Regulation of Localization of Abat 117 0.38 8.67 87.59 69.32
159 INT8357 Gene_expression of KNG1 153 0.75 77.26 68.66 68.84
160 INT3167 Binding of KNG1 48 0.48 23.26 26.77 68.84
161 INT5116 Gene_expression of IL2 670 0.78 291.13 146.69 67.80
162 INT102611 Negative_regulation of Positive_regulation of Mapk1 74 0.58 35.57 39.37 66.64
163 INT5008 Localization of Calca 204 0.81 80.35 125.16 66.32
164 INT5588 Positive_regulation of Negative_regulation of Fos 3 0.49 0.68 1.42 65.04
165 INT7056 Positive_regulation of Gene_expression of PENK 35 0.70 14.31 18.21 64.96
166 INT5590 Negative_regulation of Fos 144 0.59 40.94 81.98 63.88
167 INT9011 Negative_regulation of Nrtim1 15 0.30 2.35 12.58 63.88
168 INT2289 Gene_expression of PENK 203 0.78 55.62 79.49 63.76
169 INT9132 Negative_regulation of Prkcg 279 0.59 88.05 203.47 62.48
170 INT201185 Negative_regulation of Gene_expression of SLPI 1 0.06 0.19 0.11 61.48
171 INT142131 Negative_regulation of Csnk1e 1 0.04 0.52 0.56 60.48
172 INT109559 Localization of Napa 16 0.61 1.3 2.42 60.40
173 INT40565 Gene_expression of SLPI 15 0.75 7.25 2.21 60.40
174 INT201184 Positive_regulation of Gene_expression of SLPI 1 0.07 0.19 0.11 60.40
175 INT76531 Transcription of Trpv1 62 0.72 23.69 34.77 56.80
176 INT141253 Regulation of Transcription of Trpv1 7 0.62 3.54 3.62 56.80
177 INT9158 Gene_expression of Tnf 722 0.78 522.01 277.68 56.60
178 INT118156 Binding of Prkcz 2 0.08 2.68 2.89 56.52
179 INT18357 Gene_expression of TRPV1 825 0.78 307.11 382.81 56.48
180 INT81087 Gene_expression of ASIC3 30 0.75 13.62 16.54 56.04
181 INT2339 Positive_regulation of CB 30 0.29 10.68 9.12 55.04
182 INT15508 Negative_regulation of nt 8 0.36 3.4 2.26 54.64
183 INT6665 Gene_expression of FOS 520 0.77 165.31 217.66 53.76
184 INT17459 Positive_regulation of Gene_expression of FOS 182 0.67 53.45 96.38 53.76
185 INT85190 Positive_regulation of FOSL1 5 0.67 4.21 3.97 53.12
186 INT80573 Positive_regulation of Gene_expression of MAPK11 1 0.02 2.13 0.82 52.96
187 INT5228 Positive_regulation of Fos 934 0.70 209.8 503.87 52.48
188 INT80572 Gene_expression of MAPK11 2 0.18 2.59 0.45 52.16
189 INT9798 Negative_regulation of Gene_expression of Homer1 10 0.41 2.04 3.77 51.52
190 INT38731 Localization of Trpv1 138 0.81 52.73 90.49 51.24
191 INT5597 Gene_expression of Pdyn 433 0.78 62.97 235.47 50.08
192 INT5593 Positive_regulation of Gene_expression of Pdyn 114 0.70 29.1 74.46 50.08
193 INT11854 Gene_expression of Il1rl1 57 0.77 30.19 38.25 50.08
194 INT11855 Positive_regulation of Gene_expression of Il1rl1 19 0.69 12.22 14.57 50.08
195 INT6483 Gene_expression of TNF 3152 0.78 2515.62 929.82 50.00
196 INT5059 Positive_regulation of TNF 1050 0.70 896.51 322.81 50.00
197 INT867 Gene_expression of IFNA1 930 0.78 594.85 168.03 50.00
198 INT48895 Gene_expression of Il10 333 0.78 221.2 138.52 50.00
199 INT6926 Regulation of Pag1 72 0.39 55.79 65.09 50.00
200 INT14740 Gene_expression of TGFB1 272 0.78 168.48 60.18 50.00
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