P:Nicotine

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pChart

Pain Term
Category Drug
Synonyms None
Pain Specific No
Documents 2492
Hot Single Events 200
Hot Interactions 72

Molecular Interactions

The table below shows the top 200 pain related interactions that have been reported for Nicotine. They are ordered first by their pain relevance and then by number of times they were reported for Nicotine. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Interaction String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT105423 Jun Positive_regulation of Gene_expression of Penk 1 0.43 0 1.09 100.00
2 INT98833 Th Regulation of Gene_expression of Drd2 1 0.19 0.64 1.27 100.00
3 INT98832 Th Regulation of Dbh 1 0.32 0.53 1.2 100.00
4 INT243494 Binding of Vta1 and LOC308670 1 0.01 0.06 1.06 100.00
5 INT105424 Creb1 Positive_regulation of Gene_expression of Penk 1 0.49 0 0.55 100.00
6 INT105421 Fos Positive_regulation of Gene_expression of Penk 1 0.54 0 0.55 100.00
7 INT105422 Fosl2 Positive_regulation of Gene_expression of Penk 1 0.31 0 0.55 100.00
8 INT356199 GOPC Positive_regulation of Acot7 1 0.04 0.33 0.4 100.00
9 INT68298 Binding of Neurod1 and Abt1 1 0.24 0 0.26 100.00
10 INT23626 Ache Regulation of Mir343 1 0.17 0 0.24 100.00
11 INT257895 Positive_regulation of Sostdc1 Positive_regulation of Positive_regulation of GRIN1 1 0.00 0.09 0.83 99.98
12 INT82064 Negative_regulation of Gnrh1 Negative_regulation of Localization of LH 1 0.40 0 0.61 99.98
13 INT82065 Negative_regulation of Gnrhr Negative_regulation of Localization of LH 1 0.45 0 0.61 99.98
14 INT54460 Binding of Abt1 and Chrna9 1 0.03 0.31 0.26 99.96
15 INT303691 KNG1 Positive_regulation of AHR 1 0.03 0.98 0.69 99.86
16 INT303689 Regulation of KNG1 Positive_regulation of AHR 1 0.03 0.99 0.69 99.86
17 INT81769 Binding of Chrna4 and Neurod1 1 0.35 0.07 0.69 99.76
18 INT257896 Sostdc1 Positive_regulation of Positive_regulation of GRIN1 1 0.00 0.09 0.83 99.60
19 INT153516 PLG Positive_regulation of Pas5a 1 0.57 0.05 0.83 99.60
20 INT8719 Npy Negative_regulation of Localization of Calca 1 0.06 0.26 1.39 99.46
21 INT103000 Cpe Regulation of Penk 1 0.07 0.19 0.62 99.04
22 INT29837 Gnrh1 Positive_regulation of LH 6 0.67 0 3.53 98.82
23 INT53648 Acot1 Positive_regulation of Localization of Calca 2 0.23 0 2.61 98.64
24 INT190524 Ros1 Positive_regulation of Nfkb1 3 0.02 4.24 2.06 98.30
25 INT212824 WAS Positive_regulation of Cnr1 1 0.21 0.62 1.16 98.18
26 INT212815 WAS Positive_regulation of CNR1 1 0.01 0.62 1.16 98.18
27 INT244461 CS Positive_regulation of ESR1 1 0.06 1.15 0.05 98.00
28 INT105716 Vta1 Regulation of Nfasc 1 0.14 0 1.89 97.88
29 INT105717 Vta1 Regulation of Nfasc Regulation of Nfasc 1 0.15 0 0.63 97.88
30 INT208763 Binding of CSF2 and TPH1 1 0.07 0.65 0.19 97.12
31 INT281798 CFD Regulation of Positive_regulation of Chrna4 1 0.01 0.24 0.24 96.40
32 INT88080 Binding of Chrna4 and Psmb6 1 0.03 0.56 0.46 96.04
33 INT2714 Pomc Positive_regulation of Localization of Prl 17 0.79 0.5 8.18 95.72
34 INT179444 Hmmr Negative_regulation of Gpr156 1 0.03 0 1.79 95.72
35 INT261629 Binding of CPD and TRPC5 1 0.04 0.52 0.32 95.60
36 INT1313 Pomc Positive_regulation of Prl 7 0.35 0 4.19 95.28
37 INT131072 Cc2d1b Negative_regulation of Prkcg 1 0.01 0 0.58 95.12
38 INT49225 Mdk Regulation of Tac1 1 0.00 0 0.53 95.04
39 INT344748 NFKB2 Regulation of Gene_expression of GAD1 1 0.07 0.87 0.33 94.76
40 INT303720 Prkaca Regulation of Bdkrb1 1 0.02 0.33 0.52 93.44
41 INT281797 Positive_regulation of Chrna4 Positive_regulation of Gene_expression of VEGFA 1 0.01 0.43 0.3 93.28
42 INT245920 Binding of GLA and TRPV1 1 0.09 0.36 0.26 92.72
43 INT245926 Binding of ABCC1 and TRPV1 1 0.17 0.36 0.26 92.72
44 INT158282 Binding of Penk and Csf2 1 0.33 0.87 1.44 91.36
45 INT158283 Binding of Penk and Accn4 1 0.07 0.87 1.43 91.36
46 INT131173 Chrna7 Positive_regulation of Localization of Abat 1 0.10 0 1.01 91.28
47 INT114364 Hmgb1 Positive_regulation of Gene_expression of TNF 2 0.05 1.85 1.06 89.72
48 INT261631 Binding of CYP2A6 and CYP2B6 1 0.18 0.32 0.18 89.68
49 INT114555 Binding of Calca and St3gal3 1 0.01 0.44 1.03 89.36
50 INT114554 Binding of St3gal3 and Trpv1 1 0.01 0.44 1.03 89.36
51 INT158964 FosB Negative_regulation of Creb1 1 0.21 0 2.07 89.20
52 INT114553 Binding of Trpv1 and Col4a4 1 0.01 0.44 1.03 89.04
53 INT114552 Binding of Calca and Col4a4 1 0.01 0.44 1.02 89.04
54 INT123260 Binding of Gabrg2 and Serpini1 1 0.02 0.63 1.16 88.80
55 INT123261 Gabrg2 Regulation of Serpini1 1 0.01 0.63 1.16 88.80
56 INT355103 Binding of Ins2 and Ins1 1 0.12 2 0.21 88.16
57 INT183177 Binding of FGFR3 and NUDT6 1 0.06 1.08 0.84 86.80
58 INT307045 Tmie Negative_regulation of Positive_regulation of Casp3 1 0.01 0.29 0.85 86.68
59 INT207186 Binding of Adipoq and Bmi1 1 0.01 1.65 0.18 86.56
60 INT261628 Binding of CHRNA3 and MAOA 1 0.22 1.61 0.17 86.12
61 INT183176 Binding of FGFR2 and NUDT6 1 0.05 1.07 0.84 86.00
62 INT261626 Binding of CHRNA5 and MAOA 1 0.22 1.6 0.17 85.68
63 INT183175 Binding of FGF2 and NUDT6 1 0.07 1.07 0.84 85.44
64 INT87769 Binding of Acot1 and Treh 1 0.00 0 0.35 83.52
65 INT71176 Binding of ICAM1 and ITGB2 4 0.21 4.93 1.07 82.12
66 INT229931 Negative_regulation of Binding of C3 and CFH 1 0.08 1.35 0.17 82.12
67 INT229928 Binding of C3 and CFH 1 0.07 1.35 0.17 81.60
68 INT261627 Binding of CPD and SNRNP70 1 0.01 0.36 0.08 81.44
69 INT303690 KNG1 Positive_regulation of CPOX 1 0.01 0.76 0.96 81.28
70 INT141605 Gene_expression of Ctsl Positive_regulation of Positive_regulation of MET 1 0.34 0 0.8 80.56
71 INT180600 MAOB Positive_regulation of TAC1 1 0.00 0.13 0.22 80.48
72 INT261625 Binding of CHRNA3 and CPD 1 0.07 0.35 0.08 80.32
73 INT64735 Mptp1 Positive_regulation of Mpz 1 0.22 0.59 0.14 79.76
74 INT123077 Cacna1c Negative_regulation of Gene_expression of Dbi 1 0.05 0.71 0.7 77.52
75 INT261630 Binding of CPD and NHS 1 0.02 0.69 0.15 76.04
76 INT190525 Acot1 Positive_regulation of Localization of S100a8 1 0.00 0.86 0.63 72.80
77 INT190526 Acot1 Positive_regulation of Il1 1 0.01 0.87 0.63 72.80
78 INT311524 Gnrhr Positive_regulation of Transcription of Grin2a 1 0.02 0.54 0.55 72.72
79 INT311521 Gnrhr Positive_regulation of Gene_expression of Gria1 1 0.00 0.54 0.54 72.72
80 INT311522 Gnrhr Positive_regulation of Transcription of Gria1 1 0.00 0.54 0.54 72.72
81 INT348321 Binding of POMC and ASPM 1 0.02 0.39 0.23 72.44
82 INT137732 Binding of Nts and Ang 1 0.30 0 0.33 71.48
83 INT171186 Binding of PPFIA4 and ACOT1 1 0.00 0.37 0.42 71.40
84 INT290554 Pdyn Positive_regulation of Gpr3 Positive_regulation of Phosphorylation of Oprk1 1 0.17 0.47 0.7 71.28
85 INT290541 Gpr3 Positive_regulation of Phosphorylation of Oprk1 1 0.18 0.45 0.69 71.28
86 INT353372 Dio1 Positive_regulation of Grin1 1 0.16 0 0.98 70.96
87 INT171185 Binding of NEUROD1 and ACOT1 1 0.01 0.37 0.42 70.76
88 INT2457 Agt Positive_regulation of Localization of Avp 5 0.59 0.2 1.09 70.52
89 INT171183 Binding of BHLHE23 and ACOT1 1 0.01 0.36 0.42 70.36
90 INT311528 Binding of Grin2d and Ltp 1 0.00 0.37 0.28 70.08
91 INT290547 Pdyn Positive_regulation of Gpr3 1 0.21 0.42 0.7 69.76
92 INT290539 Positive_regulation of Pdyn Positive_regulation of Gpr3 1 0.21 0.42 0.7 69.76
93 INT330984 Negative_regulation of CYP2D6 Positive_regulation of Localization of CYP1A2 1 0.46 0 0.62 68.80
94 INT245919 Binding of TRPV1 and MRPS7 1 0.47 0 0.06 68.44
95 INT116892 Binding of TRPV1 and Phax 4 0.00 0.1 1.24 68.24
96 INT93306 Binding of TRPV1 and CAP1 2 0.18 0.07 0.97 68.24
97 INT85037 Binding of Cct2 and Chrna3 1 0.00 0.15 0.38 66.80
98 INT117909 Mastl Positive_regulation of Mapk1 1 0.04 0 0.79 66.72
99 INT245951 Binding of FIBP and Phax 1 0.00 0 0.09 66.72
100 INT245921 Binding of FIBP and CAP1 1 0.00 0 0.09 66.72
101 INT335514 NR1I2 Regulation of Gene_expression of ABCB1 1 0.66 2.42 0.54 66.68
102 INT75148 Binding of ADRA1B and ZNF594 1 0.00 0.16 0.18 64.80
103 INT148061 Binding of Tacr1 and B4galt4 1 0.01 0.06 0.77 64.40
104 INT148062 Binding of Tacr1 and St3gal3 1 0.01 0.06 0.77 64.40
105 INT171188 Positive_regulation of Binding of NEUROD1 and TNIP1 1 0.08 0 0.1 61.44
106 INT171187 Positive_regulation of Binding of PPFIA4 and TNIP1 1 0.01 0 0.1 61.44
107 INT171182 Binding of PPFIA4 and TNIP1 1 0.01 0 0.1 61.20
108 INT171184 Binding of NEUROD1 and TNIP1 1 0.06 0 0.1 61.20
109 INT324828 ELANE Positive_regulation of Localization of Ecm1 1 0.00 0.61 0.09 60.68
110 INT241776 Binding of AVP and Positive_regulation of ADCY1 1 0.06 0.54 0.32 60.08
111 INT245922 Binding of GLA and FIBP 1 0.00 0 0.03 59.24
112 INT245917 Binding of GLA and ABCC1 1 0.05 0 0.03 59.24
113 INT245923 Binding of ABCC1 and FIBP 1 0.00 0 0.03 59.04
114 INT16586 Binding of Drd2 and Nts 1 0.12 0 0.43 57.56
115 INT90387 ROS1 Positive_regulation of NFKB1 4 0.32 2.35 0.87 56.72
116 INT306020 Binding of LBP and Tlr4 1 0.13 0.34 0.66 54.56
117 INT229977 Binding of amd and Cfb 1 0.03 2.78 0.06 54.40
118 INT229985 Binding of C2 and amd 1 0.01 1.89 0.06 54.40
119 INT90388 NFKB1 Positive_regulation of CPOX 1 0.32 0.18 0.35 52.44
120 INT2458 Apoa2 Positive_regulation of Localization of Avp 1 0.10 0 0.11 50.96
121 INT179443 Vta1 Positive_regulation of Gpr156 1 0.20 0 1.99 50.00
122 INT179445 Vta1 Positive_regulation of Gabrd 1 0.09 0 1.98 50.00
123 INT303721 KNG1 Positive_regulation of Bdkrb1 1 0.05 0.75 0.52 50.00
124 INT303722 KNG1 Positive_regulation of Bdkrb2 1 0.01 0.7 0.52 50.00
125 INT190527 TNF Positive_regulation of Gene_expression of Ros1 1 0.01 1.02 0.68 49.88
126 INT229982 Binding of C3 and amd 1 0.02 1.14 0.06 46.40
127 INT201378 Bdnf Regulation of Gene_expression of Ltp 1 0.00 0.21 0.07 45.48
128 INT286683 Gopc Positive_regulation of MBD2 1 0.01 1.07 0.11 45.36
129 INT245952 Phax Negative_regulation of TRPV1 1 0.00 0.06 0.1 44.28
130 INT245927 CAP1 Negative_regulation of TRPV1 1 0.02 0.06 0.1 43.96
131 INT245918 MRPS7 Negative_regulation of TRPV1 1 0.41 0.06 0.1 43.76
132 INT110967 REG1A Positive_regulation of Gene_expression of CTSB 1 0.01 0 0.04 42.52
133 INT236468 TP53 Positive_regulation of Protein_catabolism of SNRPB 1 0.00 0.52 0 41.36
134 INT351444 Grin1 Positive_regulation of Gria2 1 0.22 1.5 2.64 40.92
135 INT244452 CS Positive_regulation of Phosphorylation of EIF2S2 1 0.21 2.07 0.09 40.52
136 INT324829 ROS1 Positive_regulation of Gene_expression of Ecm1 1 0.00 0.66 0.09 38.36
137 INT267136 Binding of CD44 and FN1 2 0.04 0.56 0 37.36
138 INT242164 Wnt2 Positive_regulation of Localization of Apc 1 0.13 1.53 0.32 34.88
139 INT222537 Binding of Nmu and Hpse 1 0.01 0.15 0 33.72
140 INT214141 Binding of Lep and Lepr 1 0.32 0.82 0.12 31.60
141 INT280451 IER5 Positive_regulation of Phc1 1 0.00 0.56 0.09 30.80
142 INT244458 CS Positive_regulation of ERN1 1 0.17 0.71 0 30.56
143 INT21315 AGT Positive_regulation of Npy 1 0.03 0.15 0.5 25.00
144 INT75149 Binding of CALCRL and ZNF594 1 0.00 0.08 0.39 25.00
145 INT75150 ZNF594 Negative_regulation of Binding of CALCRL and ZNF594 1 0.00 0.08 0.39 25.00
146 INT245925 GLA Regulation of TRPV1 1 0.07 0 0 24.32
147 INT245924 ABCC1 Regulation of TRPV1 1 0.11 0 0 24.32
148 INT241780 Binding of AVP and TRGV9 1 0.12 2.41 0.35 21.04
149 INT251665 LRP5 Negative_regulation of Ache 1 0.31 0.39 0.19 19.80
150 INT217648 Binding of fa and Hmgcr 1 0.00 0.89 0.03 18.92
151 INT198957 Binding of Cnr1 and Mastl 1 0.00 0 1.31 16.44
152 INT261579 Serpinc1 Negative_regulation of Gene_expression of CYBB 1 0.00 1.69 0.18 13.76
153 INT192080 Foxm1 Positive_regulation of Cnr1 2 0.14 0.72 1.3 13.52
154 INT307046 Tmie Positive_regulation of Cnr1 1 0.05 0.31 0.69 13.52
155 INT292598 CNR1 Regulation of ABAT 1 0.08 0.32 0.75 9.04
156 INT292599 CNR1 Regulation of Localization of ABAT 1 0.08 0.32 0.75 9.04
157 INT2161 Gnrh1 Positive_regulation of Localization of LH 33 0.73 0.87 14.34 5.00
158 INT16531 Ghrh Positive_regulation of Localization of Gh1 31 0.64 2.12 14.2 5.00
159 INT106559 Binding of Bdnf and Ntrk2 23 0.43 11.09 7.33 5.00
160 INT227157 Binding of PEBP1 and Gpm6a 1 0.00 1.28 5.52 5.00
161 INT20133 Trh Positive_regulation of Localization of Prl 23 0.78 2.04 5.44 5.00
162 INT1392 Trh Regulation of Prl 15 0.29 2.47 4.29 5.00
163 INT249566 Binding of Oprd1 and Psmd1 1 0.01 0.82 3.8 5.00
164 INT85743 Pdyn Positive_regulation of Oprk1 3 0.32 2.12 3.52 5.00
165 INT180984 IRF6 Positive_regulation of Localization of IL8 7 0.11 2.13 3.47 5.00
166 INT222522 Il1a Positive_regulation of Gene_expression of Il6 2 0.06 1.79 2.79 5.00
167 INT249567 Positive_regulation of Binding of Oprd1 and Psmd1 1 0.01 0.66 2.5 5.00
168 INT214144 Cck Positive_regulation of Pomc 1 0.15 0.94 2.39 5.00
169 INT214159 Cck Positive_regulation of Nts 1 0.03 0.93 2.34 5.00
170 INT198958 Cnr1 Positive_regulation of Kcnj9 1 0.00 0.15 2.24 5.00
171 INT86179 TNF Positive_regulation of Localization of IL6 5 0.35 1.66 2.17 5.00
172 INT196586 Negative_regulation of Mapk14 Negative_regulation of TNF 2 0.04 2.02 2.08 5.00
173 INT245348 Binding of Abat and Vta1 1 0.03 0.53 2.01 5.00
174 INT205152 Binding of CD44 and MMP9 23 0.35 17.13 1.85 5.00
175 INT267133 Binding of ICAM1 and VCAM1 25 0.32 25.43 1.83 5.00
176 INT9786 Gnrh1 Regulation of LH 7 0.40 0.58 1.82 5.00
177 INT215100 Binding of Hmgb1 and Tlr4 5 0.29 3.21 1.68 5.00
178 INT215096 Binding of Hmgb1 and Tlr2 9 0.38 11.61 1.61 5.00
179 INT79778 Tlr4 Positive_regulation of Localization of TNF 4 0.08 4.21 1.61 5.00
180 INT245347 Binding of Penk and Vta1 1 0.05 0.14 1.53 5.00
181 INT293009 IRF6 Positive_regulation of Positive_regulation of CA2 1 0.04 0.66 1.49 5.00
182 INT293013 IL8 Positive_regulation of Positive_regulation of CA2 1 0.12 0.66 1.49 5.00
183 INT227152 Positive_regulation of Binding of Mop3 and Gpm6a 1 0.00 0 1.39 5.00
184 INT227151 Binding of Mop3 and Gpm6a 1 0.00 0 1.38 5.00
185 INT290542 Crh Positive_regulation of Insr 1 0.02 0.36 1.36 5.00
186 INT249565 Binding of Gabrg1 and Oprd1 1 0.00 0.1 1.33 5.00
187 INT178986 Binding of MMP9 and TIMP1 4 0.47 2.58 1.33 5.00
188 INT281479 Drd2 Positive_regulation of Penk 1 0.23 0.4 1.3 5.00
189 INT78066 Tlr4 Positive_regulation of Localization of Il6 5 0.03 0.76 1.25 5.00
190 INT328743 TNF Positive_regulation of Mapk14 1 0.04 1.4 1.21 5.00
191 INT62368 Gal Positive_regulation of Localization of LH 3 0.36 0 1.2 5.00
192 INT328742 Il1 Positive_regulation of Mapk14 1 0.01 1.4 1.2 5.00
193 INT209132 Binding of Drd2 and Riok3 1 0.01 1.57 1.16 5.00
194 INT222516 Binding of Calcrl and Ramp1 5 0.17 0.11 1.12 5.00
195 INT307047 Foxm1 Positive_regulation of Casp3 1 0.11 0.06 1.03 5.00
196 INT144108 Binding of SLC6A3 and SLC6A4 1 0.12 0.64 1.03 5.00
197 INT293014 IRF6 Positive_regulation of Localization of CA2 1 0.04 0.71 1.02 5.00
198 INT293008 IL8 Positive_regulation of Localization of CA2 1 0.11 0.71 1.01 5.00
199 INT245349 Binding of Abat and Gpr156 1 0.02 0.26 1 5.00
200 INT351443 Cnr1 Regulation of Positive_regulation of Vta1 1 0.12 0.93 0.99 5.00

Single Events

The table below shows the top 200 pain related interactions that have been reported for Nicotine. They are ordered first by their pain relevance and then by number of times they were reported in Nicotine. Please click on the 'INT' link to display more detailed information on each interaction.

Int No Page link Event String Documents TM Confidence Disease Relevance Overall Pain Relevance Term Relevance
1 INT5050 Regulation of Localization of Calca 149 0.62 41.25 148.57 100.00
2 INT4759 Negative_regulation of Localization of Calca 294 0.59 82.62 226.45 100.00
3 INT14151 Gene_expression of Casp3 311 0.78 140.26 120.68 100.00
4 INT197459 Gene_expression of Sostdc1 10 0.01 1.04 4.11 100.00
5 INT4358 Positive_regulation of Localization of Avp 195 0.70 30.79 77.58 100.00
6 INT7286 Regulation of Transcription of Penk 81 0.62 9.25 33.45 100.00
7 INT24309 Binding of Sdhb 2 0.36 0.98 3.03 100.00
8 INT161 Regulation of Localization of Prl 615 0.62 65.37 298.66 100.00
9 INT125305 Regulation of SPANXB1 7 0.23 5.25 6.37 100.00
10 INT416 Regulation of LH 253 0.62 31.48 125.55 100.00
11 INT7287 Positive_regulation of Transcription of Penk 103 0.70 19.81 50.37 100.00
12 INT7327 Regulation of Th 164 0.62 29.67 110.14 100.00
13 INT90313 Negative_regulation of Gene_expression of Casp3 57 0.57 22.23 26.77 100.00
14 INT197458 Positive_regulation of Sostdc1 11 0.01 3.02 4.87 100.00
15 INT162 Regulation of Prl 794 0.62 165.01 322.24 100.00
16 INT797 Regulation of Penk 812 0.62 111.13 542.24 100.00
17 INT148190 Positive_regulation of Transcription of Nanog 1 0.49 0.2 3.17 100.00
18 INT6436 Positive_regulation of Positive_regulation of Fos 101 0.70 18.71 57.96 100.00
19 INT121561 Negative_regulation of Binding of Sdhb 1 0.41 0.74 1.2 100.00
20 INT49552 Negative_regulation of Positive_regulation of Casp3 76 0.55 36.04 44.78 100.00
21 INT6129 Positive_regulation of Localization of AVP 63 0.70 30.44 16.64 100.00
22 INT159 Negative_regulation of Localization of Prl 416 0.59 55.34 171.8 100.00
23 INT4289 Positive_regulation of Localization of Gnrh1 202 0.70 12.3 84.01 100.00
24 INT2379 Positive_regulation of Localization of LH 349 0.70 27.86 144.53 100.00
25 INT5743 Localization of NA 104 0.59 14.35 35.29 100.00
26 INT47817 Positive_regulation of Positive_regulation of Jun 21 0.66 3.7 6.83 100.00
27 INT70137 Regulation of Bdkrb2 10 0.27 5.45 4.62 100.00
28 INT4207 Regulation of Avp 267 0.62 63.72 115.33 100.00
29 INT28893 Positive_regulation of Atp5o 3 0.43 0.27 2.9 100.00
30 INT22579 Localization of Efs 35 0.65 2.77 16.05 100.00
31 INT2159 Regulation of Localization of Gnrh1 200 0.62 13.28 99.07 100.00
32 INT2213 Regulation of EP300 10 0.54 4.72 4.5 100.00
33 INT2276 Regulation of Ins1 234 0.61 103.78 54.05 100.00
34 INT2780 Regulation of Gene_expression of Penk 265 0.62 32.45 143.88 100.00
35 INT2106 Regulation of Localization of LH 279 0.62 22.37 122.77 100.00
36 INT4509 Gene_expression of IgG 426 0.76 293.69 56.64 100.00
37 INT75521 Positive_regulation of Positive_regulation of SGSM3 13 0.67 7.99 13.54 100.00
38 INT1353 Negative_regulation of Localization of Acot1 153 0.53 15.05 75.17 100.00
39 INT3440 Negative_regulation of Localization of Abat 221 0.57 33.94 180.36 100.00
40 INT5501 Regulation of Oprd1 283 0.62 55.1 249.9 100.00
41 INT2960 Regulation of Dbh 32 0.47 10.32 18.94 100.00
42 INT5591 Regulation of Gene_expression of Fos 425 0.62 129.06 265.78 100.00
43 INT7134 Localization of KNG1 127 0.79 65.73 67.97 100.00
44 INT257893 Negative_regulation of Positive_regulation of Sostdc1 1 0.01 0 0.9 100.00
45 INT18357 Gene_expression of TRPV1 825 0.78 307.11 382.81 100.00
46 INT90647 Regulation of Camk2g 2 0.41 0 1.22 100.00
47 INT12652 Negative_regulation of Negative_regulation of Gnrh1 6 0.43 0 3.89 100.00
48 INT215964 Binding of Cbs 1 0.39 1.13 0.7 100.00
49 INT59334 Regulation of Chrna9 6 0.44 0.62 3.26 100.00
50 INT11590 Regulation of Negative_regulation of LH 10 0.39 2.02 4.25 100.00
51 INT22582 Regulation of Localization of Efs 1 0.02 0 0.56 100.00
52 INT22581 Positive_regulation of Localization of Efs 3 0.03 0 1.63 100.00
53 INT299978 Regulation of FTSJ3 1 0.07 8.47 1.36 100.00
54 INT213 Negative_regulation of Localization of AVP 46 0.59 19.78 16.79 100.00
55 INT168269 Negative_regulation of Positive_regulation of Ppara 3 0.38 0.57 1.87 100.00
56 INT6127 Regulation of Localization of AVP 60 0.62 15.12 20.84 100.00
57 INT6382 Regulation of Binding of Oprd1 36 0.61 7 26.48 100.00
58 INT28460 Negative_regulation of Localization of Slc6a3 5 0.36 0.24 2.9 100.00
59 INT62254 Negative_regulation of FLII 20 0.48 4.11 9.44 100.00
60 INT60145 Regulation of Negative_regulation of Ltp 4 0.23 1.82 4.09 100.00
61 INT5979 Gene_expression of Oprd1 428 0.78 75.64 320.32 100.00
62 INT28832 Negative_regulation of Positive_regulation of Bdkrb1 3 0.23 1.36 2.04 100.00
63 INT133789 Regulation of Gene_expression of Bdkrb1 5 0.39 3 2.38 100.00
64 INT242390 Regulation of Gene_expression of Bdkrb2 3 0.31 1.37 1.06 100.00
65 INT300010 Regulation of Gene_expression of SPANXB1 2 0.20 0.53 0.86 100.00
66 INT303713 Regulation of Positive_regulation of SPANXB1 1 0.04 0 0.45 100.00
67 INT303706 Regulation of Positive_regulation of Bdkrb1 2 0.19 0.64 0.85 100.00
68 INT2055 Regulation of Gnrh1 185 0.62 23.65 71.26 100.00
69 INT1309 Positive_regulation of Localization of Gnrhr 152 0.69 24.25 81.56 100.00
70 INT114750 Negative_regulation of Gene_expression of Bdkrb2 4 0.17 2.68 3.64 100.00
71 INT10807 Regulation of Chrna3 1 0.31 0 0.84 100.00
72 INT144959 Binding of Chrna3 2 0.29 0 0.37 100.00
73 INT2782 Regulation of Gene_expression of Pomc 75 0.62 15.04 38.97 100.00
74 INT55352 Regulation of Gene_expression of Ppt1 9 0.44 0.4 3.51 100.00
75 INT22580 Negative_regulation of Localization of Efs 9 0.25 0.24 4.24 100.00
76 INT1474 Regulation of Localization of Ins1 132 0.61 25.96 43.07 100.00
77 INT17425 Regulation of Gene_expression of Ins1 23 0.45 18.99 5.61 100.00
78 INT12608 Regulation of CNR1 62 0.60 24.36 36.02 100.00
79 INT52464 Negative_regulation of Bdkrb1 9 0.57 8.71 5.87 100.00
80 INT28456 Negative_regulation of Positive_regulation of Slc6a3 2 0.32 0 1.38 100.00
81 INT3962 Regulation of AGT 50 0.62 20.96 13.01 100.00
82 INT5378 Regulation of Gene_expression of Fos 47 0.60 14.47 26.41 100.00
83 INT12265 Positive_regulation of IgG 168 0.63 104.89 19.76 100.00
84 INT89669 Negative_regulation of Positive_regulation of Prkcq 1 0.08 0.23 0.87 100.00
85 INT26643 Negative_regulation of Positive_regulation of Th 12 0.59 1.26 7.74 100.00
86 INT103039 Negative_regulation of Positive_regulation of SPANXB1 2 0.06 1.08 1.31 100.00
87 INT53998 Positive_regulation of MAOB 8 0.61 1.22 2 100.00
88 INT272768 Gene_expression of Nrxn3 5 0.78 4.73 3.31 100.00
89 INT123251 Regulation of Gene_expression of Chrna4 2 0.27 0.36 0.67 100.00
90 INT113935 Localization of UTS2 1 0.66 0 0.38 100.00
91 INT59332 Regulation of Gene_expression of Chrna9 3 0.55 0 0.58 100.00
92 INT303707 Negative_regulation of Transcription of Bdkrb1 1 0.16 0.31 0.42 100.00
93 INT15026 Negative_regulation of Localization of NA 26 0.36 3.76 10.69 100.00
94 INT123255 Regulation of Chrna7 1 0.44 0.36 0.49 100.00
95 INT123254 Regulation of Chrna4 3 0.27 0.84 0.76 100.00
96 INT52695 Regulation of Ptgs2 20 0.42 8.72 5.71 100.00
97 INT310381 Positive_regulation of Gene_expression of Nrxn3 1 0.03 1.19 1 100.00
98 INT398 Localization of AGT 45 0.78 16.97 11.54 100.00
99 INT237390 Localization of Casz1 2 0.55 1.39 0.66 100.00
100 INT15299 Gene_expression of IL1RL1 37 0.69 10.09 3.43 100.00
101 INT5489 Localization of CA2 172 0.80 39.46 33.56 100.00
102 INT215454 Regulation of amd 4 0.38 8.07 0.29 100.00
103 INT107342 Binding of INMT 1 0.06 0.93 0.21 100.00
104 INT351991 Localization of Chrne 1 0.04 0.12 0.18 100.00
105 INT4758 Positive_regulation of Localization of Calca 557 0.70 138.55 411.04 99.98
106 INT6853 Positive_regulation of SPANXB1 17 0.40 14.05 16.14 99.98
107 INT477 Localization of Avp 813 0.81 131.58 300.4 99.98
108 INT7258 Localization of Sult1b1 42 0.68 0.17 17.85 99.98
109 INT5228 Positive_regulation of Fos 934 0.70 209.8 503.87 99.98
110 INT157 Positive_regulation of Localization of Prl 790 0.70 104.54 374.78 99.98
111 INT1044 Negative_regulation of Localization of LH 358 0.59 25.95 151.31 99.98
112 INT22548 Positive_regulation of Casp3 483 0.70 258.78 213.07 99.98
113 INT28834 Positive_regulation of Bdkrb1 38 0.69 30.48 26.89 99.98
114 INT85510 Positive_regulation of Bdkrb2 23 0.70 12.08 12.68 99.98
115 INT113038 Positive_regulation of Gene_expression of Bdkrb1 12 0.69 7.11 7.93 99.98
116 INT3766 Positive_regulation of Localization of Acot1 192 0.69 21.8 85.35 99.98
117 INT139556 Positive_regulation of Chrna4 10 0.25 4.52 2.36 99.98
118 INT5202 Positive_regulation of Gene_expression of Fos 1163 0.70 319.28 684 99.98
119 INT4829 Positive_regulation of Localization of Abat 199 0.55 20.91 150.48 99.98
120 INT152668 Negative_regulation of EP300 13 0.38 7.78 9.03 99.98
121 INT50767 Positive_regulation of Nanog 14 0.67 3.63 8.56 99.98
122 INT2122 Negative_regulation of Localization of Gnrh1 226 0.59 26.92 92.04 99.98
123 INT1200 Negative_regulation of Ins1 274 0.58 155.17 56.14 99.98
124 INT170051 Positive_regulation of Gene_expression of Gopc 150 0.43 56.75 16.93 99.98
125 INT187190 Positive_regulation of Localization of MMP9 27 0.68 8.1 8.93 99.98
126 INT5511 Negative_regulation of Gene_expression of Pomc 47 0.59 12.08 23.02 99.98
127 INT300004 Positive_regulation of Gene_expression of SPANXB1 2 0.30 0.77 3.12 99.98
128 INT2056 Negative_regulation of Gnrh1 175 0.59 33.43 63.32 99.98
129 INT47811 Positive_regulation of Localization of Ddc 11 0.69 4 7.6 99.98
130 INT4637 Binding of Adarb1 132 0.41 14.48 67.76 99.98
131 INT45209 Positive_regulation of PLA2G2A 37 0.69 33.21 9.02 99.98
132 INT47765 Negative_regulation of Binding of Jun 21 0.43 5.05 6.38 99.98
133 INT169926 Positive_regulation of Gopc 416 0.46 157.8 58.67 99.98
134 INT1361 Negative_regulation of Gnrhr 118 0.58 57.77 35.54 99.98
135 INT75531 Regulation of MAPK1 70 0.61 34.39 15.42 99.98
136 INT1273 Gene_expression of Avp 356 0.78 90.56 138.7 99.98
137 INT67568 Positive_regulation of Localization of MMP2 14 0.31 8.58 6.79 99.98
138 INT7029 Regulation of Pdyn 51 0.61 12.89 40.34 99.98
139 INT9780 Regulation of Penk 30 0.60 6.78 17.19 99.98
140 INT114525 Negative_regulation of Positive_regulation of Egf 4 0.35 2.93 1.5 99.98
141 INT53495 Negative_regulation of Negative_regulation of PRKCA 4 0.42 2.37 3.18 99.98
142 INT336298 Gene_expression of Gtsf1 1 0.08 0.26 0.63 99.98
143 INT127668 Positive_regulation of PDE4A 12 0.68 8.39 5.13 99.98
144 INT75530 Regulation of SGSM3 11 0.60 7.22 4.48 99.98
145 INT683 Positive_regulation of AVP 173 0.70 74.55 46.41 99.98
146 INT80686 Positive_regulation of Positive_regulation of MAPK8 42 0.68 26.95 7.63 99.98
147 INT6794 Negative_regulation of Jun 37 0.53 8.04 13.37 99.98
148 INT6128 Positive_regulation of Localization of POMC 256 0.70 68.77 121.64 99.98
149 INT174421 Positive_regulation of Gene_expression of Cxcr1 2 0.53 2.58 1.75 99.98
150 INT6098 Binding of NEUROD1 17 0.47 3.4 5.99 99.98
151 INT39856 Binding of Neurod1 8 0.47 1.44 2.88 99.98
152 INT109450 Positive_regulation of Phosphorylation of AKT1 62 0.64 25.18 4.21 99.98
153 INT21901 Negative_regulation of Egf 25 0.58 10.46 4.99 99.98
154 INT65390 Positive_regulation of Plat 30 0.70 23.31 9.31 99.98
155 INT15296 Regulation of Rbm39 45 0.29 10.66 29.27 99.98
156 INT75524 Positive_regulation of Regulation of MAPK1 1 0.43 1.12 0.59 99.98
157 INT19 Regulation of Gnrhr 131 0.62 36.4 55.66 99.98
158 INT6558 Positive_regulation of Gene_expression of Th 56 0.70 9.64 30.89 99.98
159 INT254634 Positive_regulation of Positive_regulation of Bdkrb2 2 0.32 1.64 1.13 99.98
160 INT100003 Positive_regulation of Gene_expression of Serpina3m 1 0.07 0 0.6 99.98
161 INT92777 Positive_regulation of Gene_expression of ABAT 13 0.44 7.49 9.27 99.98
162 INT84809 Positive_regulation of Gene_expression of MUC1 39 0.70 36.42 3.75 99.98
163 INT18461 Positive_regulation of Localization of Pgc 17 0.65 4.41 3.99 99.98
164 INT35989 Positive_regulation of RSA-14-44 8 0.59 1.67 3.05 99.98
165 INT94132 Binding of ACOT1 7 0.13 2.62 4.04 99.98
166 INT6357 Positive_regulation of Localization of Gabrg1 53 0.41 7.03 39.21 99.98
167 INT303703 Positive_regulation of Transcription of Bdkrb1 2 0.21 2.91 2.41 99.98
168 INT20336 Positive_regulation of CYP2E1 48 0.70 19.26 15.66 99.98
169 INT13730 Negative_regulation of CHRM1 5 0.35 1.78 1.41 99.98
170 INT6417 Negative_regulation of ABAT 49 0.51 19.6 36.81 99.98
171 INT21131 Negative_regulation of Gene_expression of ABAT 6 0.42 4.93 2.83 99.98
172 INT164544 Positive_regulation of Gene_expression of P2ry12 4 0.67 2.41 1.64 99.98
173 INT14159 Negative_regulation of Positive_regulation of Adarb1 8 0.08 2.06 5.14 99.96
174 INT55870 Negative_regulation of Gene_expression of Hrh1 2 0.11 0.38 1.39 99.96
175 INT18282 Binding of SRI 10 0.36 3.31 3.59 99.96
176 INT70139 Regulation of Bdkrb1 6 0.52 8.41 6.66 99.94
177 INT2542 Localization of Calca 2008 0.81 518.3 1408.65 99.92
178 INT158 Localization of Prl 2431 0.81 378.96 952.2 99.92
179 INT5200 Gene_expression of Fos 3083 0.78 894.43 1639.02 99.92
180 INT12269 Gene_expression of Chrna9 39 0.73 6.98 18.44 99.92
181 INT1912 Gene_expression of Calca 1152 0.78 453.25 739.84 99.92
182 INT35744 Binding of MAOB 13 0.46 7.52 4.26 99.92
183 INT2640 Gene_expression of Pomc 424 0.78 120.72 155.37 99.92
184 INT117275 Localization of STATH 1 0.00 0 0.6 99.92
185 INT6278 Negative_regulation of Gene_expression of Pomc 35 0.59 11.07 14.8 99.92
186 INT261635 Binding of CPD 1 0.07 1.35 0.19 99.92
187 INT203 Positive_regulation of Pomc 257 0.70 90.56 92.84 99.92
188 INT25438 Positive_regulation of Positive_regulation of Pomc 6 0.48 4 2.37 99.92
189 INT71789 Positive_regulation of MAPK1 396 0.70 234.44 89.27 99.90
190 INT103740 Positive_regulation of Localization of Vta1 2 0.32 0.4 2.84 99.90
191 INT46833 Positive_regulation of SGSM3 56 0.67 24.49 30.31 99.90
192 INT75526 Positive_regulation of Positive_regulation of PRKCA 16 0.50 4.34 7.46 99.90
193 INT38594 Positive_regulation of Localization of BCAR1 3 0.63 0.44 3.07 99.90
194 INT5207 Negative_regulation of Alms1 70 0.41 41.56 13.68 99.90
195 INT44703 Positive_regulation of Localization of SLTM 2 0.07 0.57 0.8 99.90
196 INT155 Positive_regulation of Prl 1233 0.70 317.93 457.82 99.88
197 INT728 Positive_regulation of Penk 1068 0.70 186.9 636.87 99.88
198 INT1430 Regulation of PDYN 88 0.60 16.99 60.32 99.88
199 INT1395 Negative_regulation of Penk 537 0.59 87.33 389.81 99.88
200 INT11279 Positive_regulation of Penk 65 0.70 18.72 30.29 99.88
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